CN111228183A - Composition for conditioning skin and preparation method thereof - Google Patents
Composition for conditioning skin and preparation method thereof Download PDFInfo
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- CN111228183A CN111228183A CN202010213266.XA CN202010213266A CN111228183A CN 111228183 A CN111228183 A CN 111228183A CN 202010213266 A CN202010213266 A CN 202010213266A CN 111228183 A CN111228183 A CN 111228183A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a composition for conditioning skin and a preparation method thereof, wherein the composition comprises the following effective components: rosemary extract, erythritol, rosemary essential oil and quaternary ammonium salt-73; the preparation method comprises dissolving rosemary essential oil and quaternary ammonium salt-73 together, respectively dissolving rosemary extract and erythritol, and mixing; the composition starts from improving the composition of skin microecological flora, promotes the proliferation of resident beneficial bacteria on the skin, has good inhibiting effect on transient harmful bacteria and conditional pathogenic bacteria on the skin, ensures that the beneficial bacteria are in superiority, achieves good balance of skin microecology, maintains stable skin condition and improves skin problems.
Description
Technical Field
The invention relates to a composition for conditioning skin and a preparation method thereof, belonging to the technical field of preparation of skin care compositions.
Background
Human lives in a world full of microorganisms, bacteria can be separated from the human body after 1 hour of birth, and a large number of microorganisms are densely distributed at the parts of adults contacting or communicating with the outside.
The intestinal tract, oral cavity, skin and vagina constitute four bacterial pools. Microorganisms play an important role in human life, and directly or indirectly affect the physical health of people to cause diseases. There are many exogenous factors that affect the skin's micro-ecology, such as the temperature, humidity, air quality, frequency of health care, use of cosmetics, etc. of the external environment. Cosmetics are one of the important factors affecting the skin micro-ecology since the skin frequently contacts with cosmetics, and cosmetic ingredients directly or indirectly affect the skin micro-ecological balance. Research shows that the unbalance of intestinal microorganisms can easily cause diseases such as obesity, diabetes and the like; similarly, some common skin diseases, such as chloasma, psoriasis, atopic dermatitis, acne, etc., are closely related to the imbalance of skin microecology.
At present, skin care products on the market focus on the effects of moisturizing, resisting inflammation, relieving and the like, only aim at the appearance, and do not solve the problems from the aspect of skin micro-ecological balance, so that the effect is poor, and the skin problem caused by the imbalance of microorganisms is not fundamentally solved.
Disclosure of Invention
In order to overcome the defects of the prior art, the first object of the invention is to provide a skin conditioning composition, which starts from improving the composition of skin microecological flora, promotes the proliferation of resident beneficial bacteria of the skin, has good inhibition effect on transient harmful bacteria and conditional pathogenic bacteria of the skin, enables the beneficial bacteria to be in superiority, achieves good balance of skin microecology, maintains stable skin condition and improves skin problems.
A second object of the present invention is to provide a method for preparing the above skin conditioning composition, which can combine and cooperate the ingredients to obtain a composition having a light weight and a simple use.
The first purpose of the invention can be achieved by adopting the following technical scheme: a skin conditioning composition comprising the active ingredients: rosemary extract, erythritol, rosemary essential oil and quaternary ammonium salt-73.
Further, the effective components are as follows according to the parts by weight:
further, the composition for conditioning the skin also comprises 76-92 parts of a solvent.
Further, the solvent includes at least one of water, butanediol, and 1, 2-pentanediol.
Further, the composition for conditioning the skin comprises the following active ingredients in parts by weight:
the second purpose of the invention can be achieved by adopting the following technical scheme: a method for preparing a skin conditioning composition comprises dissolving rosemary essential oil and quaternary ammonium salt-73 together, and mixing the rosemary extract and erythritol respectively.
Further, adding a solvent which is 1-2 times of the total mass of the solute into the rosemary essential oil and the quaternary ammonium salt-73 for dissolving; dissolving erythritol in a solvent with the mass of 1-5 times that of the erythritol; dissolving herba Rosmarini officinalis extract in 5-20 times of solvent.
Further, the solvent includes at least one of water, butanediol, and 1, 2-pentanediol.
The formulation design principle of the invention is as follows: the rosemary extract is generally extracted from rosemary leaves soaked in a compound and can be divided into oil-soluble extract (an antioxidant) and water-soluble extract (an antioxidant and a preservative), wherein the former is mainly carnosic acid, and the latter is mainly rosmarinic acid; the combination of the rosemary extract, the rosemary essential oil and the erythritol can well regulate the skin microbial flora, not only can enhance the sterilization and bacteriostasis effects of the quaternary ammonium salt-73 on skin harmful flora such as propionibacterium acnes and the like, but also can reduce the reduction quantity of skin beneficial bacteria or skin resident flora.
Compared with the prior art, the invention has the beneficial effects that:
1. the composition for conditioning the skin can be directly used on the surface of the skin, is researched aiming at most of microbial flora on the surface of the skin, and has the components capable of promoting the proliferation of resident beneficial bacteria of the skin and good inhibiting effect on the temporary harmful bacteria and conditional pathogenic bacteria of the skin;
2. the skin conditioning composition of the invention ensures that beneficial bacteria are in superiority and achieves good balance of skin micro-ecology, thereby maintaining stable skin condition and improving skin problems;
3. the preparation method of the skin conditioning composition can effectively and uniformly disperse the active ingredients in a pre-dissolving mode, and the finally obtained composition is uniform, light and thin in texture and is not easy to precipitate at the same temperature in a high-temperature and high-humidity environment.
Detailed Description
The invention will be further described with reference to specific embodiments:
the composition for conditioning the skin (model is RX-W) comprises the following active ingredients in parts by weight:
wherein the solvent comprises water, butanediol and 1, 2-pentanediol. The 1, 2-pentanediol solvent can be used as a solvent and a preservative at the same time to replace the conventional preservative hydroxyacetophenone, so that the irritation of the composition is reduced.
The combination of the rosemary extract, the rosemary essential oil and the erythritol can well regulate skin microbial flora, not only can enhance the bactericidal and bacteriostatic effects of the quaternary ammonium salt-73 on skin harmful flora (staphylococcus aureus and the like) and conditional pathogenic bacteria (propionibacterium acnes and the like) such as propionibacterium acnes and the like be enhanced, but also the reduction amount of skin beneficial bacteria (staphylococcus epidermidis and the like) or skin resident flora can be reduced, so that the beneficial bacteria are in superiority, the good balance of skin micro-ecology is achieved, and meanwhile, the irritation of a conventional preservative on the skin can be effectively reduced.
The quaternary ammonium salt-73 is used as a high-efficiency bacteriostatic agent, particularly has an inhibiting effect on bacteria and fungi under the condition of extremely low usage amount, particularly has a strong antibacterial effect on propionibacterium, but has a very excellent bacteriostatic effect, and often has an influence on beneficial bacteria or symbiotic bacteria on the surface of skin, so that the balance of microbial flora on the surface of the skin is easily destroyed, and the skin is sensitive and the acne is frequent; the invention effectively solves the problems by compounding the quaternary ammonium salt-73 with the rosemary extract and the rosemary essential oil. The rosemary extract and the rosemary essential oil contain more than 1000 active molecules, including flavone, organic acid, alkaloid and the like, and can improve the survival of beneficial bacteria or symbiotic bacteria when the bacteriostatic agent damages the beneficial bacteria or the symbiotic bacteria.
Erythritol is a sugar with a low energy value (only 5-10% of the energy size of sucrose). In the skin microecological flora growth environment, energy sources of the microecological flora are mainly glucose, mannose, lactose and the like, and erythritol can inhibit the absorption and the transportation of glucose by competitively inhibiting a phosphoenolpyruvate dependent phosphate invertase system (PEP-PTS) of propionibacterium acnes. After erythritol enters the body of this propionibacterium, it is phosphorylated, and its product inhibits the activity of enzymes required for sugar metabolism. Thereby inhibiting the proliferation of harmful bacteria. And the resident bacteria staphylococcus epidermidis has small influence.
The skin conditioning composition was prepared as follows:
adding a solvent which is 1-2 times of the total mass of the solute into the rosemary essential oil and the quaternary ammonium salt-73 for dissolving; dissolving erythritol in a solvent with the mass of 1-5 times that of the erythritol; dissolving herba Rosmarini officinalis extract in 5-20 times of solvent; mixing the components after dissolving, and adding the rest solvent during mixing to obtain the final product.
The skin conditioning composition can be added into most skin care ingredients, can also be directly applied, has a better hydrophilic system, and can be compatible with most water-based care ingredients in cosmetics; the skin conditioning composition is a transparent liquid with uniform texture and stable system, has better stability, and is not easy to delaminate or precipitate under the environment of high temperature and high humidity for a long time.
Examples 1 to 5:
the skin conditioning compositions of examples 1-5, the active ingredients are shown in table 1 by weight parts:
TABLE 1 amounts of ingredients (parts by weight) of examples 1-5
Preparation of examples 1 to 3:
the skin conditioning composition was prepared as follows:
adding a solvent which is 1 time of the total mass of the solute into the rosemary essential oil and the quaternary ammonium salt-73 for dissolving; dissolving erythritol in a solvent with the mass 5 times that of the erythritol; dissolving rosemary extract in 5 times of solvent; mixing the components after dissolving, and adding the rest solvent at the same time to obtain the final product.
Preparation of examples 4 to 5:
the skin conditioning composition was prepared as follows:
adding a solvent which is 1 time of the total mass of the solute into the rosemary essential oil and the quaternary ammonium salt-73 for dissolving; dissolving erythritol in a solvent with the mass 4 times that of the erythritol; dissolving rosemary extract in 10 times of solvent; mixing the components after dissolving, and adding the rest solvent at the same time to obtain the final product.
Comparative examples were set for comparison with the examples, and the components of the comparative examples were as shown in table 2 in parts by weight:
TABLE 2 amounts of ingredients of comparative examples 1-5
| Composition (I) | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Butanediol | 1 | 2 | 4 | 5 | 10 |
| 1, 2-pentanediol | 0.1 | 0.2 | 0.5 | 0.6 | 1 |
| Water (W) | 98.9 | 97.2 | 95.5 | 94.4 | 89 |
And (3) performance detection:
first, determination of microbial inhibitory Effect
Experiment design:
1) experimental strains: propionibacterium acnes (gram-positive anaerobe (rod))
Culture medium: tryptone 15g, yeast extract 4g, glucose 10g, potassium dihydrogen phosphate 6g, sodium chloride 1.5g, anhydrous sodium carbonate 1.5g, K2HPO4-3H2O1.5 g and agar 12.5 g; the culture medium was added to each of examples 1-5 and comparative examples 1-5 to 1000 mL;
the instrument comprises the following steps: an acidimeter, an ultra-purification workbench, a steam sterilizer, an anaerobic incubator, an enzyme-labeling instrument and an electronic analytical balance.
Recovery, culture and preparation of bacterial suspension of propionibacterium acnes: inoculating lyophilized Propionibacterium acnes standard strain into TPY medium at 37 deg.C and 90% N2、10％CO2After culturing for 24h under the condition, taking a single bacterial colony to inoculate in a TPY solid culture medium, culturing for 24h under the same condition, then selecting the single bacterial colony to a TPY liquid culture medium, after uniformly oscillating, measuring the optical density value (A value) at the wavelength of 620nm on an enzyme labeling instrument, and when the A value is 1.0, the bacterial liquid is the working bacterial suspension required by the experiment.
Comparison of growth and acid production of Propionibacterium acnes in the Medium added to examples 1-5 and comparative examples 1-5: adding 200 μ L of each bacterial suspension into 10 culture media added in examples 1-5 and comparative examples 1-5, shaking, subpackaging in small test tubes with 2mL each, and culturing in anaerobic incubator (37 deg.C, 90% N)210% CO) at 0, 2, 4, 6, 8, 10, 12, 18 and 24h respectively, measuring the A value of the liquid culture medium on a microplate reader to indicate the growth condition of the bacteria, wherein the higher the A value, the higher the number of the bacteria, the more vigorous the growth.
Blank control group is normal TPY medium.
2) Experimental strains: staphylococcus epidermidis (gram-positive cocci)
Culture medium: 17g of casein peptone, 3g of soybean peptone, 5g of sodium chloride, 2.5g of dipotassium hydrogen phosphate, 2.5g of glucose, 1g of lecithin and 807 g of tween are added into the mixture in the amount of 1-5 to 1000mL of the mixture respectively;
SCDLP medium: 17g of casein peptone, 3g of soybean peptone, 5g of sodium chloride, 2.5g of dipotassium hydrogen phosphate, 2.5g of glucose, 1g of lecithin and 807 g of tween; the culture medium was added to each of examples 1-5 and comparative examples 1-5 to 1000 mL;
the instrument comprises the following steps: an acidimeter, an ultra-purification workbench, a steam sterilizer, an anaerobic incubator, an enzyme-labeling instrument and an electronic analytical balance.
Reviving and culturing staphylococcus epidermidis and preparing bacterial suspension: inoculating a freeze-dried staphylococcus epidermidis standard strain into an SCDLP culture medium in a super clean bench, culturing for 24 hours at 36 +/-1 ℃, then taking a single bacterial colony to inoculate into a TPY solid culture medium, culturing for 24 hours under the same condition, then picking the single bacterial colony into an SCDLP liquid culture medium, measuring an optical density value (A value) at the wavelength of 620nm on an enzyme labeling instrument after uniformly oscillating, and when the A value is 1.0, taking the bacterial liquid as a working bacterial suspension required by the experiment.
Comparison of growth and acid production of Staphylococcus epidermidis in the Medium added in examples 1-5 and comparative examples 1-5: 200. mu.L of each bacterial suspension was added to 10 media to which examples 1 to 5 and comparative examples 1 to 5 were added, the mixture was shaken well and distributed into small tubes, 2mL of each tube was transferred to a constant temperature incubator (36 ℃ C. + -1 ℃ C.), and the A value of the liquid medium was measured on a microplate reader at 0, 2, 4, 6, 8, 10, 12, 18, and 24 hours, respectively, to indicate the growth of the bacteria, and the higher the A value, the greater the number of bacteria and the more vigorous the growth. Simultaneously, the pH value of the culture medium is measured by a pH meter.
Blank control group is normal TPY medium.
The results are shown in tables 3-4:
TABLE 3 growth A values of Propionibacterium acnes
TABLE 4 growth A values of Staphylococcus epidermidis bacteria
The experiments show that the composition for conditioning the skin can effectively inhibit the growth of the propionibacterium acnes; and has less effect on the growth of staphylococcus epidermidis.
Second, evaluation of efficacy
The test method comprises the following steps: 100 volunteers with oily skin and whelk were recruited and divided into 5 groups of 20 persons, and the skin-conditioning composition of example 4 was applied once a day, morning and evening, 0.5 g/time, and applied continuously for 4 weeks. For the effective scoring after use, the score of 0 has no effect, the score of 1-2 has weak effect, the score of 3-4 has strong effect, and the score of 5 has strong effect.
Table 5 efficacy test results
| Score of | Number of people scored |
| 0 point (min) | 2 |
| 1 to 2 points | 15 |
| 3 to 4 points | 70 |
| 5 points of | 13 |
As can be seen from the above table, example 4 has a good effect of suppressing the acne problem.
Therefore, the skin conditioning composition has the effects of conditioning the skin and synergistically matching all components in the composition, can effectively improve the composition of skin microecological flora, can effectively inhibit the growth of pathogenic bacteria under skin conditions, and maintains the balance of skin microecology; meanwhile, the immunity of the skin can be enhanced, the skin state is improved, the skin stabilizing effect is achieved, and the self health of the skin is recovered.
Various other changes and modifications to the above-described embodiments and concepts will become apparent to those skilled in the art from the above description, and all such changes and modifications are intended to be included within the scope of the present invention as defined in the appended claims.
Claims (8)
1. A skin conditioning composition characterized by comprising as active ingredients: rosemary extract, erythritol, rosemary essential oil and quaternary ammonium salt-73.
2. The skin conditioning composition according to claim 1, wherein the active ingredients are as follows, in parts by weight:
3. the skin conditioning composition according to claim 2 further comprising solvent 76 to 92 parts.
4. The skin conditioning composition of claim 3 wherein said solvent comprises at least one of water, butylene glycol, and 1, 2-pentanediol.
5. The skin conditioning composition according to claim 2, wherein the skin conditioning composition comprises the following active ingredients in parts by weight:
6. a method of preparing a skin conditioning composition characterized by: dissolving rosemary essential oil and quaternary ammonium salt-73 together, and dissolving rosemary extract and erythritol respectively and mixing to obtain the rosemary extract.
7. The method of preparing a skin conditioning composition according to claim 6, wherein rosemary essential oil and Quaternary ammonium salt-73 are dissolved by adding 1-2 times the total mass of the solutes; adding a solvent with the mass of 1-5 times of that of the erythritol for dissolving; dissolving the rosemary extract by adding a solvent with the mass of 5-20 times of that of the rosemary extract.
8. The method of preparing a skin conditioning composition according to claim 7 wherein said solvent comprises at least one of water, butylene glycol, and 1, 2-pentanediol.
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| CN110507581A (en) * | 2019-09-22 | 2019-11-29 | 广州君研生物科技有限公司 | A kind of oil control and acne removal preparation of plant origin and its application in cosmetics |
| CN110585114A (en) * | 2019-09-30 | 2019-12-20 | 华熙生物科技股份有限公司 | Bactericidal composition for regulating skin microbial flora and application thereof |
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| JP2007008909A (en) * | 2005-07-04 | 2007-01-18 | Advance Co Ltd | Cosmetic having antibacterial selectivity |
| CN105076403A (en) * | 2014-05-07 | 2015-11-25 | 保龄宝生物股份有限公司 | Dental caries resistant milk product containing erythritol |
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