CN103271842B - Infant skin care oil containing prinsepia utilis rogle oil and preparation method thereof - Google Patents
Infant skin care oil containing prinsepia utilis rogle oil and preparation method thereof Download PDFInfo
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- CN103271842B CN103271842B CN201310185201.9A CN201310185201A CN103271842B CN 103271842 B CN103271842 B CN 103271842B CN 201310185201 A CN201310185201 A CN 201310185201A CN 103271842 B CN103271842 B CN 103271842B
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Abstract
The invention relates to an infant skin care oil containing prinsepia utilis rogle oil and a preparation method thereof and belongs to the technical field of cosmetics and medicines. The infant skin care oil containing prinsepia utilis rogle oil comprises the following components in percentage by volume: 95-99% of prinsepia utilis rogle oil, 0.91-4.91% of lithospermum oil and 0.04-0.09% of essence. The infant skin care oil containing prinsepia utilis rogle oil has the beneficial effects that components made by utilizing natural plants are used for realizing scientific compatibility, a synergistic effect is achieved, skin of an infant can be well protected, a skin care effect is stable and lasting, and the infant skin care oil containing prinsepia utilis rogle oil is safe and reliable.
Description
Technical field
The present invention relates to cosmetics and medical art, be specifically related to a kind of baby skin protection oil containing Princepia utilis oil and preparation method thereof.
Background technology
Infant skin is more tender and lovely, often needs special nursing, nurses improperly easily to occur the problems such as eczema, be full of cracks, inflammation.Product in the market for baby skin protection mainly contains talcum powder, cream for skin care and protective skin cream etc., and wherein, talcum powder in use, also exists powder and can fly in the eye of baby, ear, mouth, thus causes babies uncomfortable; Often containing chemical composition in the composition of cream for skin care or protective skin cream, cause the symptoms such as infant skin allergy sometimes; In the skin-protection product also had, main active component is volatile, and effect is unstable lasting.Therefore, develop a kind of safety, the stable product of skin effect has become the problem needing solution badly.
The Princepia utilis system flat order of a kind of perennial Rosaceae belongs to shrub plant, and formal name used at school is total flower Folium Prinsepiae Utilis, and another name robs son fruit, is mainly distributed in the Lijiang Prefecture of Yunnan Province of China, all on the books in the ancient books and records such as " the southern regions of the Yunnan Province book on Chinese herbal medicine ", " cosmopolitian plant stack room ".Princepia utilis has heat clearing away, detoxify, invigorate blood circulation, the effect such as help digestion, and kernel is rich in abundant Princepia utilis oil.Princepia utilis oil is a kind of skin protection oils and fats of pure natural, with human body lipid closely, easily absorbed by human body skin, the moisture of skin, nutrition and elasticity can be kept, can also promote that baby lanugo comes off, make the dry and comfortable lubrication of skin.But only smear infant skin with Princepia utilis oil and carry out skin protection, effect is lasting stability not, and also also exist when being used alone Princepia utilis oil, abnormal smells from the patient is not by the shortcoming that baby likes.
Summary of the invention
The object of this invention is to provide a kind of baby skin protection oil containing Princepia utilis oil, the component utilizing natural plants to make carries out scientific compatibility, plays synergism, can protect infant skin well, and its skin effect is stable lasting, and safe and reliable.
Another object of the present invention is to provide a kind of preparation method of the baby skin protection oil containing Princepia utilis oil.
The technical solution used in the present invention is a kind of baby skin protection oil containing Princepia utilis oil, and its formula and percent by volume thereof consist of: Princepia utilis oil 95% ~ 99%, Oleum Radix Arnebiae (Oleum Radix Lithospermi) 0.91% ~ 4.91% and essence 0.04% ~ 0.09%.
As preferably, formula of the present invention and percent by volume thereof consist of: Princepia utilis oil 96% ~ 98%, Oleum Radix Arnebiae (Oleum Radix Lithospermi) 1.95% ~ 3.92% and essence 0.05% ~ 0.08%.
As preferably, formula of the present invention and percent by volume thereof consist of: Princepia utilis oil 96.94%, Oleum Radix Arnebiae (Oleum Radix Lithospermi) 3% and essence 0.06%.
As preferably, described Princepia utilis oil is by Princepia utilis heating crude oil to 50 DEG C, then adds BHT and is stirred to and dissolves completely, make after letting cool.
As preferably, the weight that described BHT adds is 0.02% ~ 0.5% of Princepia utilis crude oil weight.
As preferably, the weight that described BHT adds is 0.1% of Princepia utilis crude oil weight.
As preferably, described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is joined in the white oil being heated to 50 DEG C ~ 80 DEG C by Radix Arnebiae (Radix Lithospermi) to soak, and soaking number of times is twice, and soak time is 1 ~ 3 hour, lets cool rear filtration, makes after then collecting twice filtrate mixing.
As preferably, the weight that described white oil adds is 7.5 times of Radix Arnebiae (Radix Lithospermi) weight.
As preferably, described white oil is selected from 18
#white oil.
Baby skin protection oil of the present invention can adopt routine fashion to be prepared, and above-mentioned each component is made the preferred preparation method of baby skin protection of the present invention oil and be: after described Princepia utilis oil and Oleum Radix Arnebiae (Oleum Radix Lithospermi) mix homogeneously, then add essence, obtain finished product; Or after described Princepia utilis oil and Oleum Radix Arnebiae (Oleum Radix Lithospermi) are heated to 40 DEG C ~ 60 DEG C mix homogeneously, let cool to room temperature, then add essence, obtain finished product.
Principle of the present invention is the synergism that make use of different natural constituents, promotes its effect separately.Wherein Princepia utilis oil has the effect of moistening and repairing skin, and Oleum Radix Arnebiae (Oleum Radix Lithospermi) has the effect of Wet preserving sterilizing antiinflammatory, and BHT has antioxidative effect, and essence has the effect regulating fragrance.Above-mentioned each component compatibility uses, safe and reliable, has no stimulation to human body skin; its percutaneous permeability is good; cutin can be improved degenerate, there is moisture retention crack prevention, effectively alleviate the inflammation of tissue grade caused by pro-inflammatory cytokine and anaphylaxis; significant protective effect is had to erythrocyte hemolysis caused by ultraviolet; local metabolic can be promoted, improve body microcirculation that also there is obvious antiinflammatory fungistatic effect; be suitable for extensive crowd to use, be particularly suited for baby and use.
Detailed description of the invention
For making those skilled in the art understand production technology of the present invention and technique effect in detail, introduce application of the present invention and technique effect further with concrete production instance below.
Embodiment one:
Take the Princepia utilis heating crude oil to 50 DEG C of 100kg, the BHT then adding 10kg is stirred to and dissolves completely, lets cool, and obtains Princepia utilis oil.
Take 100kg Radix Arnebiae (Radix Lithospermi) and join the 750kg18 being heated to 80 DEG C
#soak in white oil, soaking number of times is twice, and soak time is 2 hours, lets cool rear filtration, makes Oleum Radix Arnebiae (Oleum Radix Lithospermi) after then collecting twice filtrate mixing.
Measure after the Princepia utilis oil of 96.94 liters and the Oleum Radix Arnebiae (Oleum Radix Lithospermi) of 3 liters be heated to 60 DEG C of mix homogeneously, let cool to room temperature, then add the essence of 0.06 liter, after mixing finished product.
Embodiment two:
Take the Princepia utilis heating crude oil to 50 DEG C of 100kg, the BHT then adding 2kg is stirred to and dissolves completely, lets cool, and obtains Princepia utilis oil.
Take 100kg Radix Arnebiae (Radix Lithospermi) and join the 750kg18 being heated to 60 DEG C
#soak in white oil, soaking number of times is twice, and soak time is 3 hours, lets cool rear filtration, makes Oleum Radix Arnebiae (Oleum Radix Lithospermi) after then collecting twice filtrate mixing.
Measure after the Princepia utilis oil of 98 liters and the Oleum Radix Arnebiae (Oleum Radix Lithospermi) of 1.95 liters be heated to 40 DEG C of mix homogeneously, let cool to room temperature, then add the essence of 0.05 liter, after mixing finished product.
Embodiment three:
Take the Princepia utilis heating crude oil to 50 DEG C of 100kg, the BHT then adding 20kg is stirred to and dissolves completely, lets cool, and obtains Princepia utilis oil.
Take 100kg Radix Arnebiae (Radix Lithospermi) and join the 750kg18 being heated to 50 DEG C
#soak in white oil, soaking number of times is twice, and soak time is 1 hour, lets cool rear filtration, makes Oleum Radix Arnebiae (Oleum Radix Lithospermi) after then collecting twice filtrate mixing.
Measure after the Princepia utilis oil of 96 liters and the Oleum Radix Arnebiae (Oleum Radix Lithospermi) of 3.92 liters be heated to 40 DEG C of mix homogeneously, let cool to room temperature, then add the essence of 0.08 liter, after mixing finished product.
For verifying safe and reliable and effect of the present invention, spy does following test and is described:
1, the irritation test of multiple dosing
1.1 test material
The embodiment of the present invention one products obtained therefrom.Normal saline, pharmaceutical factory, South Sinkiang, Kunming produces, lot number 990422.
Experimental animal adopts healthy Japanese big-ear white rabbit, body weight 2.4-2.6 kilogram, the quality certification number " cloud moves No. 9801st, pipe ".
1.2 methods and result
Get 2.4-2.6 kilogram of rabbit 8, male and female half and half, be divided into 2 groups at random by sex and body weight: intact skin group and damaged skin group, often organize 4.First 24 hours of administration, lost hair or feathers man's rabbit back both sides with 8% sodium sulfide, unhairing area is about 150cm
2.During test, with knife blade at damaged skin depilation district's sterilization skin each side standardized " well " word cut, cut is each about 2cm anyhow, the degree of being with oozing of blood.Two treated animals are all at depilation district, the left side uniform application embodiment of the present invention one product 1ml, and right side is smeared 1ml normal saline and compared, and every day at the upper and lower noon is respectively coated with once, continuous 7 days.During coating, animal divides cage to feed with full nutrient fodder.Medication is after 7 days, warm water washes away the embodiment of the present invention one product residual on rabbit skin, detected by an unaided eye with after drug withdrawal 1,2,3,4,5,6,7 day and carry out histopathologic examination and record coating area skin with or without erythema and edema situation, carrying out skin irritation reaction scoring and intensity evaluation by table 1 and table 2.The results are shown in Table 3.
Table 1 skin irritation reaction standards of grading
Table 3 pair rabbit skin irritation reaction result
Result of the test shows, use the embodiment of the present invention one secondary every day, each 1ml smears 7 days continuously, to rabbit intact skin and damaged skin nonirritant.Show that the present invention is to no skin irritation, safe and reliable.
2, xylol causes the impact of mice auricle swelling
2.1 experiment material
2.1.1 medicine:
The embodiment of the present invention one product.PIKANGWANG, Kuning Dianhong Pharmaceutical Co., Ltd. produces, lot number 991230.Normal saline, pharmaceutical factory, South Sinkiang, Kunming produces, lot number 990422.Dimethylbenzene, Shanghai chemical reagent work produces, lot number 65-03-22.
2.1.2 instrument:
BS110S type electronic analytical balance, German Sartorius AG.
2.1.3 animal:
Healthy one-level Kunming mouse, purchased from Kunming Institute of Botany, the quality certification number " cloud moves No. 9712nd, pipe ".
2.2 methods and result
Get 22-24 gram of mice 40, male and female half and half, be divided into 4 groups at random by sex and body weight, often organize 10.Each group of mouse right ear be uniform application normal saline 0.05ml, PIKANGWANG 20mg, the embodiment of the present invention one product 0.5ml respectively, the embodiment of the present invention one product high dose group after first time coating 10 minutes with method secondary coating.After administration 10 minutes, each group of mice every auris dextra two sides is evenly coated with 0.05ml caused by dimethylbenzene xylene scorching, left ear was not painted with contrast.Cause scorching latter 30 minutes, mice is put to death in dislocation, and with the two youngster of distilled water cleaning mice, dry moisture content, cut with position homalographic by left and right two ear with the card punch of diameter 9mm, electronic analytical balance is weighed.The difference weighed with two auricles, as swelling index, is made the significance that group difference is compared in t test, and is calculated suppression ratio.The results are shown in Table 4.
Table 4 xylol causes the impact of mice auricle swelling
Compared with matched group: * P < 0.01
Experimental result shows, mice is coated with the auricle edema that the embodiment of the present invention one product two dosage group all can significantly suppress caused by dimethylbenzene outward, has remarkable antiinflammatory action.Show that the present invention has the effect of antiinflammatory.
3, bacteriostasis research
3.1 experiment material
The embodiment of the present invention one product.
Strain:
Escherichia coli CMCC(B) 44102; Salmonella CMCC(B) 50094; Bacillus pyocyaneus CMCC(B) 10104; Staphylococcus aureus CMCC(B) 26003; Four provide by institute for drug control, Kunming, Yunnan Province.
3.2 methods and result
Get 88,20ml test tube, in every pipe, add broth bouillon 2.0ml, cap, autoclave sterilization, be divided into 8 groups, often organize 10.What in the first pipe, add sterilizing respectively is subject to reagent 2.0ml, takes out 2.0ml and put into the second pipe after mixing, the like, until the 9th pipe takes out 2.0ml reject, obtain 50%, 25% ... isoconcentration, the tenth pipe does not add medicine in contrast, to observe culture medium whether be suitable for bacterial growth; Get two test tubes add sterilizing by reagent 2.0ml, mixing is taken out 2.0ml and is discarded, and does not add antibacterial, whether has pollution to observe by reagent.Meat soup is cultivated the experimental bacteria liquid of 6-8 hour, become 10-3 concentration with aseptic broth dilution, get 0.1ml and add respectively in each group of 1-10 pipe, the incubator putting into 36 ± 1 DEG C after mixing cultivates 16-24 hour, observes with or without bacterial growth.If meat soup is muddy, represent bacterial growth, meat soup is complete limpidly to be indicated without bacterial growth, unascertainable by meat soup transferred species on bouillon agar, cultivate and observe with or without bacterial growth after 18 hours.The highest drug dilution degree do not grown with antibacterial is that this is subject to the minimum inhibitory concentration of test product.The results are shown in Table 5.
Table 5 minimum inhibitory concentration (MIC)
Note: "+" represents bacterial growth, and "-" indicates without bacterial growth
Experimental result shows, the embodiment of the present invention one product is 25% to colibacillary MIC value; Be 25% to the MIC value of Salmonella; Be 25% to the MIC value of bacillus pyocyaneus; Be 1.56% to the MIC value of staphylococcus aureus.Illustrate that the present invention has antibacterial effect.
4, on the microcirculatory impact of Mice Auricle
4.1 experiment material
4.1.1 medicine:
The embodiment of the present invention one product.Positive control, DIEDA WANHUAYOU, Guangzhou Jing Xiutang Pharmaceutical limited company, lot number 000616038.Blank, normal saline, pharmaceutical factory, South Sinkiang, Kunming, lot number 76010.
4.1.2 instrument:
MCAS-2011 type Clinical Microcirculation image analysis system, Chongqing Tianhai Medical Equipment Co., Ltd. produces.
4.1.3 animal:
Healthy one-level Kunming mouse, Kunming Institute of Botany supplies, the quality certification number " cloud moves No. 9712nd, pipe ".
4.2 methods and result
Get 22-26 gram of mice 40, male and female half and half, be divided into 4 groups at random by sex and body weight: blank group, positive controls, the embodiment of the present invention one product high dose group and low dose group, often organize 10.After 10% urethane 0.15ml/10g intraperitoneal injection of anesthesia mice, fixing auricle, mouse temperature is kept with electric warming pad, under being placed in the Microcirculation observation instrument of amplification 240 times, with suitable blood capillary, (artery and vein is generally parallel, for third level branch) be the object of observation, gather the image of administration forward and backward 5 minutes, 10 minutes and 15 minutes respectively, measure following four indexs: 1. (fluidised form divides 5 grades to blood fluidised form: stagnation is 0 point; Miniflow is 1 point; Grain linear flow is 2 points; Line grain stream is 3 points; Linear flow is 4 points); 2. arteriole caliber (A
3); 3. venule diamater (V
3); 4. capillary open number (the blood capillary intersection in the computer screen visual field is counted).Each treated animal presses 0.01ml/ dosage auricle coating only, and the embodiment of the present invention one product high dose group is only coated with 0.02ml/, observes and records the situation of change of each index before and after coating, and comparing the significance of group difference.The results are shown in Table 6, table 7, table 8 and table 9.
Table 6 is on the impact (X ± SD) of Mice Auricle microcirculation fluidised form
Compared with matched group: P > 0.05
Table 7 couple Mice Auricle arteriole (A
3) impact (X ± SD, um)
Compared with matched group: P > 0.05
Table 8 couple Mice Auricle venule (V
3) impact (X ± SD, um)
Compared with matched group: * P < 0.05, * * P < 0.01
Table 9 is on the impact (X ± SD) of the open number of Mice Auricle blood capillary crossing net
Compared with matched group: * P < 0.05, * * P < 0.01
Experimental result shows, the embodiment of the present invention one product two dosage group all significantly can increase Mice Auricle microcirculation capillary open number; Low dose group obviously can increase the caliber of venule, and high dose group also has the trend of increase.Show that the present invention significantly can improve microcirculation.
Claims (8)
1. the baby skin protection oil containing Princepia utilis oil, is characterized in that: its formula and percent by volume thereof consist of: Princepia utilis oil 95% ~ 99%, Oleum Radix Arnebiae (Oleum Radix Lithospermi) 0.91% ~ 4.91% and essence 0.04% ~ 0.09%;
Described Princepia utilis oil is by Princepia utilis heating crude oil to 50 DEG C, then adds BHT and is stirred to and dissolves completely, make after letting cool;
Described Oleum Radix Arnebiae (Oleum Radix Lithospermi) is joined in the white oil being heated to 50 DEG C ~ 80 DEG C by Radix Arnebiae (Radix Lithospermi) to soak, and soaking number of times is twice, and soak time is 1 ~ 3 hour, lets cool rear filtration, makes after then collecting twice filtrate mixing.
2. a kind of baby skin protection oil containing Princepia utilis oil according to claim 1, is characterized in that: its formula and percent by volume thereof consist of: Princepia utilis oil 96% ~ 98%, Oleum Radix Arnebiae (Oleum Radix Lithospermi) 1.95% ~ 3.92% and essence 0.05% ~ 0.08%.
3. a kind of baby skin protection oil containing Princepia utilis oil according to claim 1, is characterized in that: its formula and percent by volume thereof consist of: Princepia utilis oil 96.94%, Oleum Radix Arnebiae (Oleum Radix Lithospermi) 3% and essence 0.06%.
4. a kind of baby skin protection oil containing Princepia utilis oil according to claim 1, is characterized in that: the weight that described BHT adds is 0.02% ~ 0.5% of Princepia utilis crude oil weight.
5. a kind of baby skin protection oil containing Princepia utilis oil according to claim 4, is characterized in that: the weight that described BHT adds is 0.1% of Princepia utilis crude oil weight.
6. a kind of baby skin protection oil containing Princepia utilis oil according to claim 1, is characterized in that: the weight that described white oil adds is 7.5 times of Radix Arnebiae (Radix Lithospermi) weight.
7. a kind of baby skin protection oil containing Princepia utilis oil according to claim 6, is characterized in that: described white oil is selected from 18
#white oil.
8., based on a preparation method for baby skin protection oil according to any one of claim 1-3, it is characterized in that: after described Princepia utilis oil and Oleum Radix Arnebiae (Oleum Radix Lithospermi) mix homogeneously, then add essence, obtain finished product; Or after described Princepia utilis oil and Oleum Radix Arnebiae (Oleum Radix Lithospermi) are heated to 40 DEG C ~ 60 DEG C mix homogeneously, let cool to room temperature, then add essence, obtain finished product.
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104814910A (en) * | 2015-04-30 | 2015-08-05 | 柳州立洁科技有限公司 | Baby skin-care oil |
| CN106236646A (en) * | 2016-08-29 | 2016-12-21 | 丽江永胜星海生物科技有限公司 | Facial treatment essence oil containing Princepia utilis and preparation method thereof |
| CN115475118A (en) * | 2021-06-16 | 2022-12-16 | 广州悦荟化妆品有限公司 | Cleansing gel with low irritation and skin barrier repairing function and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229108A (en) * | 2007-01-26 | 2008-07-30 | 王洪飞 | Use of prinsepia utilis royle oil for preparing baby buttocks care product |
| CN101406510A (en) * | 2008-11-20 | 2009-04-15 | 安乡县人民医院 | Groomwell root oil and preparation method thereof |
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2013
- 2013-05-17 CN CN201310185201.9A patent/CN103271842B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229108A (en) * | 2007-01-26 | 2008-07-30 | 王洪飞 | Use of prinsepia utilis royle oil for preparing baby buttocks care product |
| CN101406510A (en) * | 2008-11-20 | 2009-04-15 | 安乡县人民医院 | Groomwell root oil and preparation method thereof |
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