CN103977158A - Repairing solution for treating soft tissue trauma of animals and preparation method thereof - Google Patents
Repairing solution for treating soft tissue trauma of animals and preparation method thereof Download PDFInfo
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- CN103977158A CN103977158A CN201410241899.6A CN201410241899A CN103977158A CN 103977158 A CN103977158 A CN 103977158A CN 201410241899 A CN201410241899 A CN 201410241899A CN 103977158 A CN103977158 A CN 103977158A
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Abstract
The invention relates to the field of medical treatment, and particularly relates to a repairing solution for treating soft tissue trauma of animals and a preparation method thereof. The repairing solution is prepared from the following raw material components in parts by weight: 5-15 parts of camphor oil, 45-60 parts of yolk oil, 5-15 parts of tetrastigma hemsleyanum diels et gilg and 10-20 parts of eugenol. The repairing solution can be used for repelling parasites in animal hairs, is suitable for treating symptoms of lipsotrichia, pruritus, erythema, incrustation, pustule and other skin diseases of animals, has excellent antibacterial and anti-inflammatory effects, can be used for effectively solving the infection problems of virus, fungi, bacteria and the like on animal local skin, and has the effect of promoting an injured part to actively heal, thus shortening the time of wound healing in the process of treating the wound. Furthermore, the components of the repairing solution are safe and do not have toxic or side effect, so that no adverse influence is generated when the animal licks the repairing solution after the repairing solution is applied to the wound surface of an animal.
Description
Technical field
The present invention relates to medical field, in particular to treating repair liquid of animal soft tissue wound and preparation method thereof.
Background technology
When various different force act on animal body, cause that the destruction of animal organism soft tissue structure is called wound, this class wound is often with part and general reaction in various degree.Traumatogenic common cause has thrusting of sharp property object (as steel wire, crotch), the cutting of sheet glass, iron plate etc., and club hits, and baits mutually wound etc.In addition, the human body ulcer that animal self-disease forms also belongs to wound category.
In correlation technique, medicine about treatment animal cuticle wound has multiple in the market, these products are mostly to take anti-inflammation as main, common medicine is as, medicines such as iodine tincture, ethanol, bromo geramine, normal saline, antibiotic liquid, sulfa powder, broad ectrum antibiotic, adrenocortical hormones, aspirin and Phenylbutazone.The mechanism of its treatment wounds in animals is for wound face provides an antibacterial local environment of protecting from infection, and makes wound surface normal healing, and it does not have and makes the initiatively effect of healing of wound site.Therefore, use these traditional medicines to make the required time of wound healing all long.
Summary of the invention
The object of the present invention is to provide a kind of repair liquid for the treatment of animal soft tissue wound, to solve the above problems.
Another object of the present invention is to provide a kind of preparation method of repair liquid of above-mentioned treatment animal soft tissue wound.
The repair liquid that treatment animal soft tissue wound is provided in an embodiment of the present invention, according to parts by weight meter, its material component comprises: Oleum Camphora 5-15 part, egg oil 45-60 part, tetratigma hemsleyanum 5-15 part, eugenol 10-20 part.
The repair liquid of this treatment animal soft tissue wound provided by the invention, by theory of Chinese medical science compatibility, draws materials each plant extract and configures.Its mechanism is as follows: Camphora, and pungent, hot, there is dehumidifying parasite killing, warming and odynolysis, has one's ideas straightened out and wards off dirty effect.< < Bencao Pinhui Jingyao > > cloud " the main parasite killing of Camphora, except scabies, treats sore due to scald and burn, enemy's oxious gas ".< < surgery great achievement > > record " if with dried Alumen, Calomelas be smalls altogether, wet dry mixing, dry oil dresses, and can control ecthyma " (as perfume (or spice) falls apart in vain); < < surgery is the raw cloud " if be divided into end with Realgar, the used time first decocts soup with Herba Schizonepetae and washes affected part, then adjusts and be coated with Oleum Sesami, can control scrofula and fester, as loose in male brain " of > > that collects entirely.Oleum Camphora be by Lignum cinnamomi camphorae do and leaves through water vapour distillation, there is the function of whole Camphoras.The odor property of Camphora, anthelmintic sterilizing (parasite in animal skin is its wound to be caused to the key factor of infection), has special treatment and preventive effect to the skin injury of house pet.Tetratigma hemsleyanum is the exclusive swag Wild Medicinal of China.Cool in nature, sweet in the mouth, have no side effect (China is among the people normal outer for controlling venom, skin cellulitis, traumatic injury), have heat-clearing and toxic substances removing antimicrobial and anti-inflammation efficacy.Egg oil contains the Multiple components such as rich in protein, vitamin A, riboflavin, lecithin, oleic acid, linoleic acid, fat, zinc, ferrum, can promote the growth of mucosal epithelium tissue, increases body anti-infective ability, the healing of acceleration of wound tissue.As < < Compendium of Materia Medica > > cloud " ovum gallinaceum is fried and is got oil, and powder applies head sore ".Flos Caryophylli is cool in nature, and bitter and puckery flavor is nontoxic, enters lung, spleen, stomach, kidney four warps.< < Quanzhou book on Chinese herbal medicine > > cloud " Flos Caryophylli heat-clearing and toxic substances removing, relieving stranguria by diuresis; Harness the river swollen, stranguria with blood, carbuncle, furuncle, innominate toxic swelling ".Eugenol is the main active of Flos Caryophylli, its pharmacological action is extremely extensive, main manifestations reaches antioxidation for removing oxygen-derived free radicals, inhibited to malignant bacteria and fungus, Fish are had to anesthetic action, can promote Drug Percutaneous Absorption, by affecting PO/AH (PO/AH) Thermosensitive Neurons, reach refrigeration function, have the mosquito of dispelling effect etc., the application prospect in animal husbandry is produced is boundless.
This repair liquid that the embodiment of the present invention provides, the parasite in its energy animal repelling hair; The dermatosis symptoms such as the depilation of applicable treatment animal, pruritus, erythema, incrustation, pus born of the same parents; There is good antibacterial and anti-inflammation functions, can effectively treat the infection problems such as the local virus of animal skin, fungus and bacterium; Compare with wound medicine common in prior art, it not only has the effect of sterilization, and in addition, it also possesses the effect that the wound site of making initiatively heals, and can effectively promote the growth of wound surface cell tissue, repairs epidermis, mucosal tissue wound and ulcer; So it,, in the process for the treatment of wound, has shortened the required time of wound healing, has broad application prospects.
In addition, this repair liquid provided by the invention, the equal safe without toxic side effect of its component, so when it smears to the wound surface of animal, animal licks to lick and has no adverse effects.Overcome and licked while licking the wound surface that scribbles common anti-inflammation drugs in prior art when animal, may cause to animal the defect of various toxic and side effects.
Optionally, described tetratigma hemsleyanum is Powdered between 110-130 order of particle diameter.
It is a kind of according to the preparation method of the repair liquid of above-mentioned treatment animal soft tissue wound that the embodiment of the present invention also provides, and comprises the following steps:
Tetratigma hemsleyanum is crushed to Powdered;
The egg oil of set parts by weight is heated to after 60-80 ℃, adds therein the Powdered tetratigma hemsleyanum of set parts by weight, obtain solidliquid mixture;
Described solidliquid mixture is naturally cooled to room temperature, add therein Oleum Camphora and the eugenol of set parts by weight, stir, obtain repair liquid.
Optionally, in described step, the egg oil of set parts by weight is heated to after 60-80 ℃, adds therein the Powdered tetratigma hemsleyanum of set parts by weight, obtain in solidliquid mixture:
When adding the Powdered tetratigma hemsleyanum of set parts by weight, stir, and at 60-80 ℃ of insulation 50-70 minute.
Optionally, at the described egg oil by set parts by weight, be heated to after 60-80 ℃, add therein the Powdered tetratigma hemsleyanum of set parts by weight, obtain in the step of solidliquid mixture, described heating is specially uses electric food warmer to heat.
Accompanying drawing explanation
In order to be illustrated more clearly in the specific embodiment of the invention or technical scheme of the prior art, to the accompanying drawing of required use in the specific embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is some embodiments of the present invention, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
The preparation flow schematic diagram of the repair liquid of the treatment animal soft tissue wound that Fig. 1 provides for the embodiment of the present invention four.
The specific embodiment
For making the object, technical solutions and advantages of the present invention clearer; to technical scheme of the present invention be carried out to clear, complete description below; the specific embodiment based in the present invention; those of ordinary skills are resulting all other embodiments under the prerequisite of not making creative work, all belong to the scope that the present invention protects.
The repair liquid of this treatment animal soft tissue wound provided by the invention, according to parts by weight meter, its material component comprises: Oleum Camphora 5-15 part, egg oil 45-60 part, tetratigma hemsleyanum 5-15 part, eugenol 10-20 part.And preferred, described tetratigma hemsleyanum is Powdered between 110-130 order of particle diameter.
Next, the present invention, also in conjunction with above-mentioned content, provides following specific embodiment to the composition of the repair liquid for the treatment of animal soft tissue wound:
Embodiment mono-
The repair liquid of the treatment animal soft tissue wound of the present embodiment, according to parts by weight meter, its material component comprises: 5 parts of Oleum Camphoras, 45 parts of egg oil, 5 parts of tetratigma hemsleyanums, 10 parts of eugenol; Described tetratigma hemsleyanum is that particle diameter is that 120 objects are Powdered.
Embodiment bis-
The repair liquid of the treatment animal soft tissue wound of the present embodiment, according to parts by weight meter, its material component comprises: 10 parts of Oleum Camphoras, 50 parts of egg oil, 10 parts of tetratigma hemsleyanums, 15 parts of eugenol; Described tetratigma hemsleyanum is that particle diameter is Powdered in 120 objects.
Embodiment tri-
The repair liquid of the treatment animal soft tissue wound of the present embodiment, according to parts by weight meter, its material component comprises: 15 parts of Oleum Camphoras, 60 parts of egg oil, 15 parts of tetratigma hemsleyanums, 20 parts of eugenol; Described tetratigma hemsleyanum is that particle diameter is that 120 objects are Powdered.
In order to make the repair liquid of the treatment animal soft tissue wound of the above embodiment of the present invention, better applied, more effectively be applied in Traditional Chinese health field, the present invention also provides embodiment tetra-on the basis of above-described embodiment, embodiment tetra-has provided the manufacture method of repair liquid of the treatment animal soft tissue wound of above-described embodiment, now be described in detail and explain, please refer to Fig. 1:
Embodiment tetra-
Please refer to Fig. 1, in the present embodiment, the preparation method of the repair liquid for the treatment of animal soft tissue wound comprises the following steps:
Step 101: tetratigma hemsleyanum is crushed to Powdered;
In this step, tetratigma hemsleyanum number belongs to a kind of Vitaceae and climbs up by holding on to this, and constant is connected, and therefore, in the process of making, after need to being dried, pulverizes, and obtains pulverous raw material, then it is mixed with other components.
Step 102: the egg oil of set parts by weight is heated to after 60-80 ℃, adds therein the Powdered tetratigma hemsleyanum of set parts by weight, obtain solidliquid mixture;
In step 102, in order to reach better drug effect, egg oil need to be heated, make it reach 60-80 ℃, and then add therein pulverous tetratigma hemsleyanum, like this, the active princlple of tetratigma hemsleyanum and egg oil can fully be separated out and mix homogeneously, and its drug effect is more remarkable.In the process of heating, preferred, adopt electric food warmer to heat, the mode of electric heating heating is comparatively slow and easy to operate, and it can effectively prevent that the thermo-labile active ingredient of part is too fast and destroyed owing to heating up.
In addition, preferred, in adding the process of tetratigma hemsleyanum powder, in order to reach the effect of mixing thoroughly, also need to stir, even if add limit to stir, and in the process adding, continue at 60-80 ℃ of insulation 50-70 minute; Like this, two uniform whiles of medicament mixed, be also beneficial to its contained drug effect component and fully separate out.
Step 103: described solidliquid mixture is naturally cooled to room temperature, add therein Oleum Camphora and the eugenol of set parts by weight, stir, obtain repair liquid.
The preparation method of the repair liquid of this treatment animal soft tissue wound that the embodiment of the present invention provides, it is easy and simple to handle, does not need complicated huge equipment can realize the preparation of repair liquid.
In addition, the present invention is usingd repair liquid that embodiment bis-provides as test sample, has carried out corresponding experimentation, and to further instruction, it has the repair function of wound healing, specifically please refer to following content:
Laboratory animal: 30 of SD rats, male and female half and half, 200 grams of left and right of body weight, purchased from University Of Nanchang's medical college Animal Experimental Study center.30 rats are divided into three groups at random, 10 every group: experimental group (A group), positive controls (B group), negative control group (C group).
Experimental drug and reagent: experimental group (A group): using medicine is " repair liquid of the embodiment of the present invention two ".Positive controls (B group): use medicine is JINGWANHONG RUANGAO, and Da Rentang pharmaceutcal corporation, Ltd produces by Tianjin, lot number 211516; Negative control group (C group): use common medical saline (0.9% sodium chloride).
Experimental technique:
1, modeling: lose hair or feathers to rat rabbit back with 8% sodium sulfide, expose the skin of about 2cm * 2cm, after 2 days, use 10% chloral hydrate anesthesia, and with iodine tincture, alcohol disinfecting, in left of spine or right side, do the circular wound surface that 1 diameter is about 1cm left and right, excision wound surface holostrome skin to superficial fascia is organized.
2, administration: from operation, A treated animal wound surface drips the repair liquid that 2-3 drips the embodiment of the present invention two certainly, drips after every day 3 times or wound surface are dry again; B forms face and is evenly coated with JINGWANHONG cream, take flap coverage as degree, every day 2-3 time; C forms face and drips normal saline, and method and frequency are organized laboratory animal with A.The administration of all animals is carried out every day, until wound healing.
3, wound healing situation is observed: the healing state of perusal wound surface, observation index is: exudate amount number, edge of wound contraction of skin, incrustation and skin color variation.
4, the mensuration of Wound healing rate and healing time: after surgery the 3rd, 7,10,14d, meter weight method measured area is retouched in employing, use transparent membrane flap coverage, along wound surface edge, mark, draw required areal extent and cut, with the analytical balance that scale division value is 0.1mg, claim quality and replace area with quality, by Wound healing rate=(original wound surface area-wound surface area does not heal)/original wound surface area, calculate Wound healing rate.The standard that 95% the Wound healing rate of take is healing time, records the healing time of each wound surface.
5, date processing: adopt SPSS17.0 statistical software to carry out one factor analysis of variance to experimental data; Row t check when variance is neat, during heterogeneity of variance, row is proofreaied and correct t check.During P<0.05, being significant difference, is difference highly significant during P<0.01.
Experimental result:
1, the healing state of rat skin wound surface:
Be observed visually each treated animal 1d and 2d after surgery, the wound surface of all animals has transudate substantially, and wound does not start healing.
Postoperative 3d, has the transudate of 3 substantially to disappear in 10 animals of C group, and starts incrustation, and all the other edge of wound contraction of skin are not obvious, and 2 wounds start to occur a little blush; The transudate of 6 wound surface of B group disappears substantially, and edge of wound skin starts to shrink, and starts incrustation, and wherein 5 wounds start to occur a little blush; In 10 animals of A group, have the transudate of 9 substantially to disappear, edge of wound skin starts to shrink, and starts incrustation, has 8 wounds to start to occur a little blush.
Postoperative 7d, C group still has 4 wound surface moistening, has exudate, and wound contraction is not obvious, has no significantly new epithelize; B group 7, nothing infection dry with 10 rat wound surface of A group, edge of wound contraction of skin is obvious.
Postoperative 14d, C group wound repair is not good enough, still has 5 not healings; 2 not healings of B group; A organizes all healed.
2, Wound healing rate and wound healing time:
The meansigma methods that each Wound healing rate of organizing experimental animal is surveyed, the overall average of wound healing time are in Table 1.
Table 1. is respectively organized wound healing rate x ± s, % and healing time
Note: in C group relatively, * P<0.05, * * P<0.01.
Above-mentioned experimental result points out repair liquid of the present invention obvious to the treatment of rat skin wound and repairing effect, has good anti-infectious function simultaneously, and no matter from wound healing rate or healing time aspect, its effect is better than JINGWANHONG RUANGAO.Therefore, repair liquid of the present invention should have same treatment and repairing effect to other mammals pet skin wound; And for animal pets, opinion typically, when it exists wound surface, most animals all exists licks the phenomenon of licking, and when the antibiotic medicine of some traumatic pains is smeared to its wound surface, toxic and side effects may occur after animal licks and licks, and has potential safety hazard.And this repair liquid that the embodiment of the present invention provides, with pure Chinese crude drug, substitute traditional Western medicine, for animal skin feature, effective bacteriostasis and sterilization, nutrition wound surface epithelial cell tissue, by strengthening animal self organism ability, realize the effect that heat-clearing and toxic substances removing accelerates the healing of wound surface, after animal licks and licks, there is not potential safety hazard in it.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (5)
1. a repair liquid for the treatment of animal soft tissue wound, is characterized in that, according to parts by weight meter, its material component comprises:
Oleum Camphora 5-15 part, egg oil 45-60 part, tetratigma hemsleyanum 5-15 part, eugenol 10-20 part.
2. the repair liquid for the treatment of animal soft tissue wound according to claim 1, is characterized in that, described tetratigma hemsleyanum is Powdered between 110-130 order of particle diameter.
3. a preparation method for the repair liquid for the treatment of animal soft tissue wound according to claim 1, is characterized in that, comprises the following steps:
Tetratigma hemsleyanum is crushed to Powdered;
The egg oil of set parts by weight is heated to after 60-80 ℃, adds therein the Powdered tetratigma hemsleyanum of set parts by weight, obtain solidliquid mixture;
Described solidliquid mixture is naturally cooled to room temperature, add therein Oleum Camphora and the eugenol of set parts by weight, stir, obtain repair liquid.
4. the preparation method of the repair liquid for the treatment of animal soft tissue wound according to claim 3, it is characterized in that, in described step, the egg oil of set parts by weight is heated to after 60-80 ℃, adds therein the Powdered tetratigma hemsleyanum of set parts by weight, obtain in solidliquid mixture:
When adding the Powdered tetratigma hemsleyanum of set parts by weight, stir, and at 60-80 ℃ of insulation 50-70 minute.
5. the preparation method of the repair liquid for the treatment of animal soft tissue wound according to claim 3, it is characterized in that, at the described egg oil by set parts by weight, be heated to after 60-80 ℃, the Powdered tetratigma hemsleyanum that adds therein set parts by weight, obtain in the step of solidliquid mixture, described heating is specially uses electric food warmer to heat.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997809A (en) * | 2015-08-10 | 2015-10-28 | 四川联成迅康医药股份有限公司 | Medicine composition for promoting wound healing. |
| CN115120535A (en) * | 2022-07-21 | 2022-09-30 | 南京欣腾瑞生物科技有限公司 | Licking external cream for relieving pruritus of cat dermatophytes and preparation method thereof |
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| CN102631408A (en) * | 2012-05-04 | 2012-08-15 | 西北农林科技大学 | Compound turpentine nano-emulsion composition and preparation method thereof |
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| CN102631408A (en) * | 2012-05-04 | 2012-08-15 | 西北农林科技大学 | Compound turpentine nano-emulsion composition and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997809A (en) * | 2015-08-10 | 2015-10-28 | 四川联成迅康医药股份有限公司 | Medicine composition for promoting wound healing. |
| CN115120535A (en) * | 2022-07-21 | 2022-09-30 | 南京欣腾瑞生物科技有限公司 | Licking external cream for relieving pruritus of cat dermatophytes and preparation method thereof |
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| CN103977158B (en) | 2017-02-15 |
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Effective date of registration: 20190412 Address after: 330002 Jiangdong Residential Area, 756 Jinggangshan Avenue, Qingyunpu District, Nanchang City, Jiangxi Province, 18 Patentee after: Zhang Guojin Address before: 330000 Room 101, Room 3, Building 35, Unit 101, Section 2, Xiangyihua City, Qingshan Lake District, Nanchang City, Jiangxi Province, No. 1269, Hubin East Road, Qingshan Lake District (1st floor) Patentee before: Jiangxi Xiang Run Science and Technology Ltd. |
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