CN102462780A - Traditional Chinese medicine composition used for treating skin scald injury - Google Patents
Traditional Chinese medicine composition used for treating skin scald injury Download PDFInfo
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- CN102462780A CN102462780A CN2010105392256A CN201010539225A CN102462780A CN 102462780 A CN102462780 A CN 102462780A CN 2010105392256 A CN2010105392256 A CN 2010105392256A CN 201010539225 A CN201010539225 A CN 201010539225A CN 102462780 A CN102462780 A CN 102462780A
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- cortex lycii
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- oleum sesami
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, specifically relates to a traditional Chinese medicine composition and a preparation technology thereof, and especially relates to a pure traditional Chinese medicine composition used for treating skin scald injuries and burns, and a preparation technology thereof. According to clinical requirements, the traditional Chinese medicine composition can be prepared into a plurality of suitable preparations.
Description
Invention field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of external medicine composition of treating skin burn.
Background technology
Skin burn is a kind of acute skin injury that takes place owing to hyperpyrexia materials such as contact fire, boiled water, deep fats.The traditional Chinese medical science is referred to as " burn ", " baked wheaten cake skin ulcer ", belongs to the clinical symptom of seeing more.Skin burn is divided into three degree by degree of injury.The damage of I degree only reaches epidermis, and local erythema is congested, and no vesicle occurs; The II degree injures skin corium, and the water scar appears in the part, and substrate is ruddy, swelling, severe pain; The III degree injures skin holostrome and muscle, even reaches osseous tissue deeply, and local skin is burned black or pale, and drying is hide-like, follows the string and consciousness.But slight burn and scald spontaneous recovery, serious skin burn then needs Drug therapy.The traditional Chinese medical science is often taked means treatment skin burns such as heat clearing away, removing heat from blood, detoxifcation, pain relieving, and is evident in efficacy.The traditional Chinese medical science is divided into 3 types, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs with skin burn.Extreme noxious heat (burn is early stage), suitable heat-clearing and toxic substances removing removing heat from blood; Intenseness of heat impairment of YIN type (burn mid-term), suitable clearing away heat and nourishing YIN; Deficiency in both Qi and blood type (burn later stage), suitable benefiting QI and nourishing blood, invigorating the spleen and regulating the stomach.But because that many Chinese medicines have an onset is slow, shortcoming such as the course of treatment is long, prescription is lengthy and tedious has a strong impact on its clinical practice.Chinese medicine composition of the present invention has that medical material is easy to get, prescription is brief, be easy to dissolving and absorb, and curative effect is fast, the characteristics that administration time is short, so curative effect is better.
Summary of the invention
The purpose of this invention is to provide a kind of pure Chinese medicine composition that is used for skin scald, burn and preparation method thereof and be suitable for preparation with various clinical.
The external medicine composition that the present invention relates to is characterized in that, the preparation of basic side is prepared from following proportion raw material medicine:
200～400 parts in 50～100 parts of Oleum Sesami of 50～100 parts of egg yolks of Cortex Lycii.
Preferably:
200～400 parts in 30～60 parts of Oleum Sesami of 100 parts of egg yolks of Cortex Lycii.
The present invention side of optimization, preparation is prepared from following proportion raw material:
200～400 parts in 30～60 parts of Oleum Sesami of 50～100 parts of Oleum Ovum Gallus domesticus Flavus of Cortex Lycii.
Preferably:
100 parts in 100 parts of Oleum Ovum Gallus domesticus Flavus of Cortex Lycii, 60 Oleum Sesami.
Cortex Lycii is the root bark of matrimony vine of solanaceae plant Lycium chinense Mill. and lycium barbarum Lycium barbarum L. in the raw material of employing of the present invention, and property is sweet, cold, returns lung, liver, kidney channel, and the effect removing heat from blood removes and steams; The egg yolk sweet in the mouth, property is flat, is slightly cold, and goes into the heart, kidney channel, and tool is nourshing Yin and drynsessmoistening prescription, the effect of nourishing blood for calming endogenous wind.Oleum Sesami is claimed Oleum Sesami, ground sesameseed oil again; Being that China adopts traditional aqua method (claiming that again water is for method), is the natural oil that from the seed Semen Sesami of Pedaliaceae plant sesame Sesamum indicum L., extracts, and its nature and flavor are sweet, cool; Go into meridian of Hand-YANG MING, the effect removing toxic substances and promoting granulation.The effect of whole medicine has removing heat from blood, moisturizes, the effect of detoxifcation, granulation promoting.
Composition of the present invention is by weight as proportioning, when producing, can increase or reduce according to corresponding proportion.But the constant rate of the raw medicinal herbs weight proportion between each is formed.
Above-mentioned Chinese medicine complex (call in the following text " bone compound recipe cream ") has the effect of good treatment skin burn.
Experimental example:Ground bone compound recipe cream is to the research of burn wound healing effect
Materials and methods
Animal: the ICR white mice, male, body weight 18～22g, Beijing dimension tonneau China laboratory animal company limited provides supply source credit number: SCXK (capital) 2009-2010.
Medicine and reagent: the Cortex Lycii fine powder, cross 200 orders, provide by professor Zhou Fengqin of pharmaceutical college of Shandong Traditional Chinese Medicine University; Ripe egg yolk, egg oil.Ground bone compound recipe cream was by Cortex Lycii powder, egg oil, starch, Oleum Sesami (1: 0.6: 0.4: 4) be mixed into cream; Cortex Lycii cream is mixed into cream by Cortex Lycii powder, starch, Oleum Sesami (1: 1: 4); Egg yolk cream is mixed into cream by starch, egg oil, Oleum Sesami (1.4: 0.6: 4); Negative control cream is mixed into cream by starch, Oleum Sesami (1: 2).Moist expose burn ointment, Shantou Mebo Pharmaceuticals Co., Ltd. produces, the accurate word 220000004 of traditional Chinese medicines, lot number: 20090309.Starch, Oleum Sesami are commercially available (annotate: starch is adjuvant).
Pentobarbital sodium, Beijing chemical reagents corporation, lot number: 090522; Na
2S, Chemical Reagent Co., Ltd., Sinopharm Group, lot number 20090313; NaCl, Beijing Chemical Plant, 20090220; The big forever chemical reagent of vaseline, Tianjin development centre, lot number 20070919;
Experimental apparatus: electronic balance, U.S. Ohaus company, AR1530 type; Electric-heated thermostatic water bath, mayor of Beijing bearing instruments and meters company, SY21-K6B type.
The dark II of mouse skin ° of scalding model ICR mice conformed for 1 week, after the cropping of back, with Na
2S: soap powder: starch (3: 1: 7) mixes, and adds water modulation scattered paste shape, brushes in its back and loses hair or feathers, and the depilation back was observed 1 day, rejected brush the wounded.Anaesthetize according to 2mg/10g body weight lumbar injection pentobarbital sodium, 15mm diameter card punch is fixed in the water-bath top, 100 ℃ of boilings of water temperature modulation, and hand-held mice exposes its skin of back and disposes directly over card punch timing 20 seconds in the water-bath top.Scald finishes pneumoretroperitoneum injection 2mg/10g sterile saline in case the mice dehydration is dead.This method can cause dark II ° of circular scald wound of the about 1.5cm of mouse back diameter.Mice is divided into 5 groups at random, 10/group, be respectively positive drug (moist expose burn ointment) group, negative control group, bone compound recipe cream group, Cortex Lycii cream group, egg yolk cream group.Administration immediately after the scald, and per 2～3h is administered once in the working time, syringe is sprayed at wound surface, and cotton rod is smeared evenly.
Incrustation, decrustation and the wound healing situation of mice in whole therapeutic process observed in the wound healing effect; After modeling and the 5th, 10,15 day to its weigh, wound surface takes pictures; And the back wound surface is carried out the template shade describe; The clip dash area scraps of paper carry out precision weighs calmly, heavily reflects wound surface area and healing state with paper.
The result
Ground bone compound recipe cream and Cortex Lycii cream have the effect that damaged skin is scalded in protection.Scalding in early days, Cortex Lycii cream can significantly promote wound tissue healing, and its effect and moist expose burn ointment be (P＞0.05) quite; Administration the 15th day, each was organized the mice damaged skin and shows certain self-healing property, but Cortex Lycii ointment and compound recipe ointment can promote the spontaneous recovery of mice damaged skin, its effect and moist expose burn ointment suitable (P＞0.05).With negative control relatively, Cortex Lycii cream can be accelerated the healing (P＜0.05) that mice is scalded the surface, ground bone compound recipe cream effect take second place (seeing accompanying drawing 1-5).
The influence (unit:
) that table 1 ground bone compound recipe cream and prescription thereof are heavy to the dark II of mice ° of scalded skin wound surface area paper
*: compare P＜0.05 with negative control group; #: with comparison in the 5th day, P＜0.05.
Table 2 ground bone compound recipe cream and prescription thereof are to the influence
of the dark II of mice ° of scalded skin wounds healed natural law
* variance analysis: compare P＜0.05 with negative control group
Description of drawings
Fig. 1 is the dark II of a mice ° skin scald illustraton of model; Fig. 2 is the research 5th day Cortex Lycii ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 3 is the research 5th day egg yolk ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 4 is the research 5th day compound recipe ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 5 is the research 5th day ointment negative control group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 6 is the research 5th day moist expose burn ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 7 is the research 10th day Cortex Lycii ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 8 is the research 10th day egg yolk ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Fig. 9 is the research 10th day compound recipe ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 10 is the research 10th day ointment negative control group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 11 is the research 10th day moist expose burn ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 12 is the research 15th day Cortex Lycii ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 13 is the research 15th day egg yolk ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 14 is the research 15th day compound recipe ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 15 is the research 15th day ointment negative control group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 16 is the research 15th day moist expose burn ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 17 is the research 20th day Cortex Lycii ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 18 is the research 20th day egg yolk ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 19 is the research 20th day compound recipe ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 20 is the research 20th day ointment negative control group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 21 is the research 20th day moist expose burn ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 22 is the research 25th day Cortex Lycii ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 23 is the research 25th day egg yolk ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 24 is the research 25th day compound recipe ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 25 is the research 25th day ointment negative control group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect; Figure 26 is the research 25th day moist expose burn ointment group mice scalded skin recovery figure of ground bone compound recipe cream to the burn wound healing effect.
The specific embodiment
The following example all can be realized the effect of above-mentioned experimental example, includes but not limited to the following example.
Embodiment 1:
The method for preparing of ointment of the present invention:
Prescription:
Cortex Lycii 100g egg yolk 100g Oleum Sesami 400ml
Method for preparing:
(1) Cortex Lycii is chosen decontamination, remove dust, oven dry is pulverized, and crosses 100 mesh sieves, and egg boils and pulverizes, and is subsequent use;
(2) above medicine is merged mixing, add Oleum Sesami and be made into ointment;
(3) said medicine is merged mixing, can add appropriate amount of starch increases adhesion.
Embodiment 2:
The method for preparing of ointment of the present invention:
Prescription:
Cortex Lycii 100g Oleum Ovum Gallus domesticus Flavus 60ml Oleum Sesami 400ml
Method for preparing:
(1) Cortex Lycii is chosen decontamination, remove dust, oven dry is pulverized, and crosses 100 mesh sieves; Egg is boiled, get egg yolk, pulverize, 60 ℃ of baking 12h make drying, add 3 times of amount petroleum ether, and 75 ℃ of reflux, extract, repeat to extract 3 times, and each 1.5h reclaims solvent behind the merge extractive liquid,, egg oil, yield is about 60%, and is subsequent use;
(2) above medicine is merged mixing, add Oleum Sesami and be made into ointment;
(3) said medicine is merged mixing, can add appropriate amount of starch increases adhesion.
Claims (10)
1. external Chinese medicine of treating skin burn is characterized in that raw material of Chinese medicine comprises: Cortex Lycii 50～200, egg yolk 50～200, Oleum Sesami 50～800, wherein, the said ratio of weight and number that the ratio of each component is;
2. a kind of external Chinese medicine of treating skin burn as claimed in claim 1; It is characterized in that this Chinese medicine is compositions; Its drug component comprises: Cortex Lycii 50～200, egg yolk 50～200, Oleum Sesami 50～800, wherein, the said ratio of weight and number that the ratio of each component is;
3. Chinese medicine composition according to claim 2 is characterized in that: said the ratio of each component is: Cortex Lycii 100, egg yolk 100, Oleum Sesami 400;
4. a kind of external Chinese medicine of treating skin burn as claimed in claim 1, it is characterized in that this Chinese medicine is compositions: its drug component comprises: Cortex Lycii 50～200, Oleum Ovum Gallus domesticus Flavus 50～200, Oleum Sesami 50～800; Wherein, the said ratio of weight and number that the ratio of each component is;
5. Chinese medicine composition as claimed in claim 4 is characterized in that the method for preparing of Oleum Ovum Gallus domesticus Flavus is: get egg yolk, pulverize; 60 ℃ of baking 12h make drying, add 3 times of amount petroleum ether, 75 ℃ of reflux, extract; Repeat to extract 3 times, each 1.5h reclaims solvent behind the merge extractive liquid; Get egg oil, yield about 60%;
6. Chinese medicine composition according to claim 4 is characterized in that: said the ratio of each component is: Cortex Lycii 100, Oleum Ovum Gallus domesticus Flavus 60, Oleum Sesami 400;
7. according to each described Chinese medicine composition of claim 1-6; It is characterized in that: said Cortex Lycii is the root bark of matrimony vine of solanaceae plant Lycium chinense Mill. and lycium barbarum Lycium barbarum L., and said egg yolk is the yolk of getting after egg boils; Oleum Sesami is the natural oil that from the seed Semen Sesami of Pedaliaceae plant sesame Sesamum indicum L., extracts;
8. the application of each described Chinese medicine of claim 1-6 in preparation treatment skin burn medicine;
9. like each described Chinese medicine of claim 1-6, it is characterized in that to add acceptable accessories or excipient.
10. like each described Chinese medicine of claim 1-6, it is characterized in that can be made into clinical acceptable forms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105392256A CN102462780A (en) | 2010-11-08 | 2010-11-08 | Traditional Chinese medicine composition used for treating skin scald injury |
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| CN2010105392256A CN102462780A (en) | 2010-11-08 | 2010-11-08 | Traditional Chinese medicine composition used for treating skin scald injury |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103357011A (en) * | 2013-07-10 | 2013-10-23 | 深圳市宝舜泰生物医药股份有限公司 | Pharmaceutical composition and composite burn cream for treating burns and scalds and preparation method thereof |
| CN108452090A (en) * | 2018-06-21 | 2018-08-28 | 郎玉柱 | A kind of preparation method of new type scald ointment |
-
2010
- 2010-11-08 CN CN2010105392256A patent/CN102462780A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 刘洪超等: "地骨皮的功效考证与现代药理学研究比较", 《山东中医药大学学报》 * |
| 唐世木: "复方蛋黄油治疗烧伤残余创面762例疗效观察", 《工企医刊》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103357011A (en) * | 2013-07-10 | 2013-10-23 | 深圳市宝舜泰生物医药股份有限公司 | Pharmaceutical composition and composite burn cream for treating burns and scalds and preparation method thereof |
| CN108452090A (en) * | 2018-06-21 | 2018-08-28 | 郎玉柱 | A kind of preparation method of new type scald ointment |
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Application publication date: 20120523 |