CN110731992A - paralysis plaster, its preparation method and paralysis plaster prepared thereby - Google Patents

paralysis plaster, its preparation method and paralysis plaster prepared thereby Download PDF

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CN110731992A
CN110731992A CN201911265884.2A CN201911265884A CN110731992A CN 110731992 A CN110731992 A CN 110731992A CN 201911265884 A CN201911265884 A CN 201911265884A CN 110731992 A CN110731992 A CN 110731992A
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paralysis
paste
oil
plaster
preparing
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胡国春
李太兵
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Lixian Hospital Of Traditional Chinese Medicine
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Lixian Hospital Of Traditional Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether

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  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to paralysis pastes and a preparation method thereof and a prepared paralysis plaster, wherein the paralysis paste prepared by selecting a plurality of traditional Chinese medicine compounds can quickly and effectively relieve rheumatism pain and lumbocrural pain, is prepared by extracting medicine materials (2) refining oil, (3) adding erysipelas paste, (4) removing fire toxin and (5) mixing, has the functions of activating blood circulation to dissipate blood stasis, diminishing inflammation and relieving pain, dispelling wind and removing dampness, and relaxing tendons and activating collaterals, has no toxic or side effect, long duration of drug effect, low cost and convenient use, reduces the tiredness of patients to oral medicines, and has the total effective rate of treating pains at the waist, back, shoulders, legs and other parts caused by rheumatism and rheumatoid diseases of 97.16 on average.

Description

paralysis plaster, its preparation method and paralysis plaster prepared thereby
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to paralysis pastes, a preparation method thereof and a prepared paralysis plaster.
Background
Rheumatism and rheumatoid diseases belong to the category of arthralgia in traditional Chinese medicine, the main symptoms of the rheumatism and rheumatoid diseases are pains, soreness, stress, numbness, bending and stretching difficulty, or joint swelling of muscles, joints, bones and muscles, which are the chronic diseases seriously harming human health , in recent years, the morbidity and the disability rate rise year by year.
The common treatment medicines for rheumatism and rheumatoid diseases are nonsteroidal anti-inflammatory medicines and hormone treatment, have large side effects and are difficult to be tolerated by patients, and the waist and leg pain does not have specific medicines at present, anti-inflammatory medicines and blood-activating medicines which are taken for a long time are troublesome and hurt the stomach, and are easy to cause that the patients do not take the medicines on time or take the medicines tired, the treatment is influenced, the psychology and the economy of the patients are greatly influenced, and the curative effect is not ideal.
Disclosure of Invention
Aiming at the technical problems, the invention aims to provide paralysis pastes, a preparation method thereof and a prepared paralysis plaster.
In order to achieve the purpose, the invention adopts the following technical scheme:
firstly, the invention provides a preparation method of paralytic plasters, which comprises the following steps:
(1) extracting medicinal materials: cutting radix Angelicae sinensis, radix Angelicae Pubescentis, radix Angelicae Dahuricae, radix Aconiti Preparata and radix Aconiti Kusnezoffii Preparata into pieces, soaking in oleum Verniciae Fordii, heating and frying until the surface of the medicinal materials is dark brown and the interior is dark yellow, and removing residue;
(2) oil refining: heating and decocting the medicinal oil with dregs removed until the oil drops into water drops;
(3) preparing paste by using the following components: adding red lead into the refined medicinal oil, and continuously stirring until the medicinal oil becomes glossy black brown paste;
(4) fire toxin removal: immersing the black brown paste into cold water, continuously stirring, changing water to cool, and standing in the cold water for 24-72 h;
(5) mixing: heating and melting the paste for removing fire toxin, and uniformly mixing the paste with dragon's blood powder and pseudo-ginseng powder to obtain the paralytic plaster.
, cutting the angelica, the pubescent angelica root, the dahurian angelica root, the prepared common monkshood mother root and the prepared kusnezoff monkshood root in the step (1) into small sections with the length of 1-2 cm.
, cutting radix Angelicae sinensis, radix Angelicae Pubescentis, radix Angelicae Dahuricae, radix Aconiti Preparata and radix Aconiti Kusnezoffii Preparata in step (1), and soaking in oleum Verniciae fordii for 30-40 min.
, heating to the oil temperature of 190-210 ℃ in the step (1).
, heating to 280-300 ℃ in the step (2).
, adding 330-350g red lead per 1000g tung oil in the step (3).
, sieving with 80-120 mesh sieve before mixing sanguis Draxonis powder and Notoginseng radix powder in step (5).
Secondly, the invention provides paralysis pastes prepared by the preparation method.
Finally, the invention also provides paralysis patches which comprise medical dressings and main medicine materials, wherein the main medicine materials are the paralysis paste.
Compared with the prior art, the invention has the following beneficial effects:
the paralysis plaster prepared by selecting a plurality of Chinese herbal medicine compounds can quickly and effectively relieve rheumatism pain and lumbocrural pain, has simple preparation method, can be prepared into a paralysis patch which is convenient to use, reduces the tiredness of patients to oral medicines, and has the advantages of quick pain relieving, definite curative effect, convenient use, economy, safety, reliability and the like.
Detailed Description
To make the objects, technical solutions and advantages of the present invention clearer and more complete, the technical solutions in the embodiments of the present invention will be described below in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention.
The materials used in the following examples are all commercially available from conventional sources.
Example 1
A method for preparing paralysis ointment, comprising the following steps:
(1) extracting medicinal materials: cutting equal mass of radix Angelicae sinensis, radix Angelicae Pubescentis, radix Angelicae Dahuricae, radix Aconiti Preparata and radix Aconiti Kusnezoffii Preparata into small segments with length of 1-2cm, soaking in oleum Verniciae Fordii for 30min, heating to 190 deg.C, frying to dark brown on the surface and brown inside, and removing residue;
(2) oil refining: continuously heating the medicinal oil with the dregs removed to 280 ℃ for cooking until the oil drops into water drops;
(3) preparing paste by using the following components: adding red lead into refined medicinal oil according to 330g per 1000g tung oil, and stirring continuously until the medicinal oil becomes glossy black brown paste;
(4) fire toxin removal: immersing the black brown paste into cold water, continuously stirring, changing water to cool, and standing in the cold water for 24 hours;
(5) mixing: heating and melting the paste for removing fire toxin, and uniformly mixing the paste with dragon's blood powder and pseudo-ginseng powder to obtain the paralytic paste, wherein the dragon's blood powder and the pseudo-ginseng powder are sieved by a sieve of 80-120 meshes before being mixed.
Example 2
A method for preparing paralysis ointment, comprising the following steps:
(1) extracting medicinal materials: cutting equal mass of radix Angelicae sinensis, radix Angelicae Pubescentis, radix Angelicae Dahuricae, radix Aconiti Preparata and radix Aconiti Kusnezoffii Preparata into small segments with length of 1-2cm, soaking in oleum Verniciae Fordii for 35min, heating to 200 deg.C, frying to dark brown on the surface and brown inside, and removing residue;
(2) oil refining: continuously heating the medicinal oil with the dregs removed to 290 ℃ for cooking until the oil drops into water drops;
(3) preparing paste by using the following components: adding red lead into refined medicinal oil according to 340g of tung oil per 1000g, and stirring continuously until the medicinal oil becomes glossy black brown paste;
(4) fire toxin removal: immersing the black brown paste into cold water, continuously stirring, changing water to cool, and standing in the cold water for 48 hours;
(5) mixing: heating and melting the paste for removing fire toxin, and uniformly mixing the paste with dragon's blood powder and pseudo-ginseng powder to obtain the paralytic paste, wherein the dragon's blood powder and the pseudo-ginseng powder are sieved by a sieve of 80-120 meshes before being mixed.
Example 3
A method for preparing paralysis ointment, comprising the following steps:
(1) extracting medicinal materials: cutting equal mass of radix Angelicae sinensis, radix Angelicae Pubescentis, radix Angelicae Dahuricae, radix Aconiti Preparata and radix Aconiti Kusnezoffii Preparata into small segments with length of 1-2cm, soaking in oleum Verniciae Fordii for 40min, heating to 210 deg.C, frying to dark brown on the surface and brown inside, and removing residue;
(2) oil refining: continuously heating the medicinal oil with the dregs removed to 300 ℃ for cooking until the oil drops into water drops;
(3) preparing paste by using the following components: adding red lead into refined medicinal oil according to 350g per 1000g tung oil, and stirring continuously until the medicinal oil becomes glossy black brown paste;
(4) fire toxin removal: immersing the black brown paste into cold water, continuously stirring, changing water to cool, and standing in the cold water for 72 hours;
(5) mixing: heating and melting the paste for removing fire toxin, and uniformly mixing the paste with dragon's blood powder and pseudo-ginseng powder to obtain the paralytic paste, wherein the dragon's blood powder and the pseudo-ginseng powder are sieved by a sieve of 80-120 meshes before being mixed.
Preparation example 1
The paralytic plaster is prepared by the method of example 1 and is smeared on a mount material according to the amount of 50g to obtain the paralytic plaster.
Preparation example 2
The paralytic plaster is prepared by the method of the embodiment 2 and is smeared on a mount material according to the amount of 50g to obtain the paralytic plaster.
Preparation example 3
The paralytic plaster is prepared by the method of the embodiment 3 and is smeared on a mount material according to the amount of 50g to obtain the paralytic plaster.
The mounting material is adhesive plaster, paper or lotus leaf.
Examples of the experiments
285 patients with rheumatic pain are clinically observed, the symptoms of the patients show pain at the waist, back, shoulders, legs and other parts caused by rheumatism and rheumatoid diseases, wherein 162 men and 123 women are 18-60 years old and are averagely divided into 3 groups, the paralysis pastes prepared in preparation examples 1-3 are respectively used for treatment, when the plaster is used, firstly, the skin of an affected part is cleaned, then the plaster is heated to enable the plaster to be uniformly heated and softened, the plaster is pasted on the affected part, treatment courses are carried out in 7 days, 53 patients are treated by taking a certain commercially available rheumatism plaster as a control, 30 men and 23 women are observed for index and curative effect evaluation, the curative effect evaluation is divided into effective, effective and ineffective according to the standard of the clinical research guiding principle of new traditional Chinese medicines, the curative effect evaluation is carried out after treatment courses, and the results are shown in the following table.
TABLE 1 clinical curative effect observation of the paralysis plaster of the present invention and a commercially available rheumatism plaster for treating rheumatalgia
Figure BDA0002312824880000041
Figure BDA0002312824880000051
As can be seen from the data in the above table, compared with a certain rheumatism plaster sold in the market, the total effective rate of the paralysis plaster prepared by steps in the invention reaches 97.16% on average, wherein the total effective rate of the treatment group 1 and the treatment group 3 reaches 96.84%, the total effective rate of the treatment group 2 reaches 97.89%, and the total effective rate of the control group is only 69.81% which is far lower than that of the paralysis plaster prepared by steps in the invention.

Claims (9)

1, paralysis pastes preparation method, characterized by, including the following steps:
(1) extracting medicinal materials: cutting radix Angelicae sinensis, radix Angelicae Pubescentis, radix Angelicae Dahuricae, radix Aconiti Preparata and radix Aconiti Kusnezoffii Preparata into pieces, soaking in oleum Verniciae Fordii, heating and frying until the surface of the medicinal materials is dark brown and the interior is dark yellow, and removing residue;
(2) oil refining: heating and decocting the medicinal oil with dregs removed until the oil drops into water drops;
(3) preparing paste by using the following components: adding red lead into the refined medicinal oil, and continuously stirring until the medicinal oil becomes glossy black brown paste;
(4) fire toxin removal: immersing the black brown paste into cold water, continuously stirring, changing water to cool, and standing in the cold water for 24-72 h;
(5) mixing: heating and melting the paste for removing fire toxin, and uniformly mixing the paste with dragon's blood powder and pseudo-ginseng powder to obtain the paralytic plaster.
2. The method for preparing paralytic ointments according to claim 1, wherein in step (1), the angelica sinensis, the radix angelicae pubescentis, the radix angelicae dahuricae, the radix aconiti preparata and the radix aconiti agrestis are cut into small segments with a length of 1-2 cm.
3. The method for preparing paralytic ointments according to claim 1, wherein in step (1), the angelica sinensis, the radix angelicae pubescentis, the radix angelicae, the radix aconiti preparata and the radix aconiti agrestis are cut into pieces and then soaked in tung oil for 30-40 min.
4. The method for preparing paralysis pastes of claim 1, wherein the heating in step (1) is carried out at an oil temperature of 190-210 ℃.
5. The method for preparing paralysis pastes of claim 1, wherein the heating in step (2) is carried out at an oil temperature of 280-300 ℃.
6. The method for preparing paralytic ointments according to claim 1, wherein in step (3), 330g red lead and 350g red lead are added per 1000g tung oil.
7. The method for preparing kinds of ointment for paralysis according to claim 1, wherein the powders of sanguis Draxonis and Notoginseng radix in step (5) are sieved with 80-120 mesh sieve before mixing.
8, paralysis pastes prepared by the process as claimed in any one of claims 1-7 to .
The paralysis plaster of claim 9 and , which is characterized by comprising medical dressing and main medicine material, wherein the main medicine material is the paralysis plaster of claim 8.
CN201911265884.2A 2019-12-11 2019-12-11 paralysis plaster, its preparation method and paralysis plaster prepared thereby Pending CN110731992A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113577186A (en) * 2021-09-17 2021-11-02 赵国庆 Compound liquid for treating orthopedic pain, preparation method and application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
任永新等: "风湿痹痛膏外贴穴位治疗痹证80例", 《陕西中医》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113577186A (en) * 2021-09-17 2021-11-02 赵国庆 Compound liquid for treating orthopedic pain, preparation method and application

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Application publication date: 20200131