CN110123976A - It is a kind of to treat hemorrhoid dai medicine smearing cream and preparation method thereof - Google Patents

It is a kind of to treat hemorrhoid dai medicine smearing cream and preparation method thereof Download PDF

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CN110123976A
CN110123976A CN201910577824.8A CN201910577824A CN110123976A CN 110123976 A CN110123976 A CN 110123976A CN 201910577824 A CN201910577824 A CN 201910577824A CN 110123976 A CN110123976 A CN 110123976A
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parts
hemorrhoid
cream
moschus
root
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李光
李宜航
陈曦
苏晶
吕亚娜
刘世芳
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Institute of Medicinal Plant Development of CAMS and PUMC
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Institute of Medicinal Plant Development of CAMS and PUMC
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Abstract

The invention discloses a kind of hemorrhoid dai medicines for the treatment of to smear cream and preparation method thereof, wherein, the treatment hemorrhoid smear cream with dai medicine, by weight, including 20~50 parts of acalypha copperleaf, 10~80 parts of hedgehog thorn, 10~50 parts of rhizoma cimicifugae dahuricae, 50~200 parts of paris polyphylla, 10~90 parts of borneol, 20~60 parts of the sophora bud, 10~50 parts of Moschus, 10~20 parts of the root bark of tree peony, 8~15 parts of radix paeoniae rubra, 10~25 parts of Pu Gonghuang, 5~10 parts of peach kernel, 10~25 parts of smilax, 2~8 parts of the root of Dahurain angelica and 100~500 parts of paste substrate.The advantage that the present invention has the therapeutic effect to hemorrhoid good and harmless.

Description

It is a kind of to treat hemorrhoid dai medicine smearing cream and preparation method thereof
Technical field
The invention belongs to ointment preparation technical fields, and in particular to a kind of to treat hemorrhoid dai medicine smearing cream and its preparation side Method.
Background technique
Dai medicine is ancient one of the traditional medicine in China, just on the books in " the pattra leaves warp " before 2500, dai medicine with Its good curative effect will be widely welcomed, and dai medicine is quickly grown under the support of government, government transfer special technical staff from Thing Dai Nationality Biography of Medical Figures nationality, the clinical list of Ming Lao Dai Nationality doctor are tested, the collection and the work of biological medicament resource investigation of secret recipe and traditional proved recipe, constantly Propulsion dai medicine application.
Hemorrhoid are under the mucous membrane of human rectum end and expansion occurs for veniplex under anal canal skin and buckling is formed by softness Venous mass.Hemorrhoid are more common in frequent standing person and long seated user, and it is anorectal bottom that hemorrhoid, which include internal piles, external piles and mixed hemorrhoid, And varicose occurs for the veniplex of anal mucosa and a kind of chronic disease of the soft venous masss of the one or more that is formed.Hemorrhoid exist Any age can all fall ill, and more common with 20~40 years old, and aggravate with age and gradually, therefore have " ten people, nine hemorrhoid " Say.
The most important symptom of hemorrhoid is hematochezia and abjection, and the bleeding that when stool can be repeated multiple times, hemorrhoid can serious harm The health of people, the treatment method of existing hemorrhoid are usually operative treatment and drug therapy, and drug therapy is divided into for oral administration again Medicine, externally applied drug and patch medicine, and it is exactly acne cream that it is most common, which to paste medicine, existing acne cream is unobvious to the effect of the treatment of hemorrhoid, It eradicates ineffective, it is difficult to alleviate the pain of patient.
Summary of the invention
In order to solve the problems, such as that existing acne cream therapeutic effect is bad, effect is treated the purpose of the present invention is to provide a kind of thus The good hemorrhoid dai medicine that is used to treat of fruit smears cream and preparation method thereof.
The technical scheme adopted by the invention is as follows:
It is a kind of to treat hemorrhoid dai medicine smearing cream, by weight, the thorn including 20~50 parts of acalypha copperleafs, 10~80 parts Hedgehog thorn, 10~50 parts of rhizoma cimicifugae dahuricae, 50~200 parts of paris polyphylla, 10~90 parts of borneol, 20~60 parts of the sophora bud, 10 ~50 parts of Moschus, 10~20 parts of the root bark of tree peony, 8~15 parts of radix paeoniae rubra, 10~25 parts of Pu Gonghuang, 5~10 parts of peach kernel, 10~ 25 parts of smilax, 2~8 parts of the root of Dahurain angelica and 100~500 parts of paste substrate.
Optimization, by weight, including 20~45 parts of acalypha copperleafs, 10~70 parts of hedgehog thorn, 10~45 parts of north Cimicifugae foetidae, 50~180 parts of paris polyphylla, 10~80 parts of borneol, 20~50 parts of the sophora bud, 10~45 parts of Moschus, 10~ 18 parts of the root bark of tree peony, 8~13 parts of radix paeoniae rubra, 10~23 parts of Pu Gonghuang, 5~9 parts of peach kernel, 10~23 parts of smilax, 2~7 The root of Dahurain angelica and 100~450 parts of paste substrate of part.
It advanced optimizes, by weight, including 20~35 parts of acalypha copperleafs, 10~50 parts of hedgehog thorn, 10~35 The rhizoma cimicifugae dahuricae of part, 50~140 parts of paris polyphylla, 10~60 parts of borneol, 20~40 parts of the sophora bud, 10~35 parts of musk deer Perfume, 12~16 parts of the root bark of tree peony, 8~11 parts of radix paeoniae rubra, 10~18 parts of Pu Gonghuang, 5~8 parts of peach kernel, 10~18 parts of native Fu Siberian cocklebur, 3~6 parts of the root of Dahurain angelica and 100~400 parts of paste substrate.
Specifically, by weight, including 30 parts of acalypha copperleafs, 40 parts of hedgehog thorn, 20 parts of rhizoma cimicifugae dahuricae, 120 parts Paris polyphylla, 50 parts of borneol, 25 parts of the sophora bud, 30 parts of Moschus, 15 parts of the root bark of tree peony, 10 parts of radix paeoniae rubra, 15 parts of Pu are public Huang, 6 parts of peach kernel, 15 parts of smilax, 5 parts of the root of Dahurain angelica and 350 parts of paste substrate.
Specifically, the paste substrate is vaseline, Babu plaster or polyethylene glycol 400.
The present invention also provides a kind of preparation methods that cream is smeared for treating hemorrhoid dai medicine, comprising the following steps:
S101. appropriate acalypha copperleaf, hedgehog thorn, rhizoma cimicifugae dahuricae, paris polyphylla, borneol and the sophora bud are crushed respectively, has been crushed It after complete and is mixed, obtains raw material powder A after mixing;
S102. the appropriate root bark of tree peony, radix paeoniae rubra, Pu Gonghuang, peach kernel, smilax and the root of Dahurain angelica are crushed respectively, is gone forward side by side after crushing completely Row mixing, obtains raw material powder B after mixing;
S103. Moschus is crushed, obtains Moschus fine powder;
S104. the ethyl alcohol that concentration is 80% is added into the raw material powder A, after mixing evenly, is obtained after impregnating 100~500h To mixture C;
S105. the ethyl alcohol that concentration is 40% is added into the raw material powder B, after mixing evenly, is obtained after impregnating 100~300h To mixture D;
S106. mixture C and mixture D are individually filtered respectively, obtain filtrate E and filtrate F;
S107. after ethyl alcohol being removed in filtrate D and filtrate F decompression volatilization respectively, medicinal extract G and medicinal extract H are obtained;
S108. medicinal extract G is mixed with medicinal extract H, obtains semi-finished product I after mixing evenly;
S109. it is heated after appropriate paste substrate being added to semi-finished product I, after heating, is kept the temperature, then obtain paste J;
S110. after paste J is cooling, Moschus fine powder is added into paste J, is evenly stirred until solidification shape, can be obtained State described in any one it is a kind of treat hemorrhoid dai medicine smear cream.
Specifically, the crushing mesh number in the step S101 and the step S102 is between 250~400 mesh, institute The crushing mesh number of Moschus in step S103 is stated also between 250~400 mesh.
Specifically, ethyl alcohol and the mass ratio of raw material powder A are 10:1 in the step S104.
Specifically, the Central Plains step S105 feed powder B and the mass ratio of ethyl alcohol are 1:8.
Specifically, heating temperature is between 100~150 DEG C, and soaking time is between 1~2.5h in the step S109 Between.
The invention has the benefit that
(1) present invention smears cream for treating hemorrhoid dai medicine to be a kind of, and constituent is acalypha copperleaf, hedgehog thorn, north Cimicifugae foetidae, paris polyphylla, borneol and the sophora bud, wherein acalypha copperleaf has effects that clearing heat and detoxicating and treatment hemorrhoid hemorrhage, hedgehog Thorn has the function for the treatment of hematochezia, discharging fresh blood stool, anal fistula and rectal prolapse, and rhizoma cimicifugae dahuricae has removing toxic substances, treatment rectal prolapse and carbuncle sore tumefacting virus Effect, paris polyphylla have effects that clearing heat and detoxicating, swelling and pain relieving, borneol have effects that treat hemorrhoid, and the sophora bud is for just The treatment of blood, hemorrhoid blood, and Moschus has effects that ease pain and reduce swelling.It, can be to hemorrhoid by extracting the drug ingedient of above-mentioned raw materials Sore has good therapeutic effect, and is free from side effects to human body, and patient can be made safe to use.
Meanwhile constituent of the invention further includes the root bark of tree peony, radix paeoniae rubra, Pu Gonghuang, peach kernel, smilax and the root of Dahurain angelica, wherein red Skin and radix paeoniae rubra have effects that clearing heat and cooling blood, activating microcirculation and removing stasis medicinal, and Pu Gonghuang has clearing heat and detoxicating effect, and peach kernel has promoting blood circulation And the effect of relax bowel and defecation, smilax have detoxicating functions, the root of Dahurain angelica has effects that apocenosis of invigorating blood circulation, by extracting above-mentioned raw materials Drug ingedient, so that the present invention has effects that dehumidification swelling, clearing heat and detoxicating, promoting blood circulation to remove blood stasis, especially suitable for hemorrhoid treating, energy Enough further therapeutic effects improved to hemorrhoid.
In conclusion smearing cream provided by the present invention for treatment hemorrhoid dai medicine, used Chinese medicine meets China People's republic's States Pharmacopoeia specifications, medicine source is safe and reliable, without any toxicity and side effects, good and harmless to the therapeutic effect of hemorrhoid.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with It obtains other drawings based on these drawings.
Fig. 1 is the specific steps process signal that the preparation method of cream is smeared provided by the present invention for treatment hemorrhoid dai medicine Figure.
Specific embodiment
The present invention is further elaborated combined with specific embodiments below.It should be noted that for these implementations The explanation of example mode is used to help understand the present invention, but and does not constitute a limitation of the invention.
Term "and/or" in text, only a kind of incidence relation for describing affiliated partner, indicates that there may be three kinds of passes System, for example, A and/or B, can indicate: individualism A, individualism B exist simultaneously tri- kinds of situations of A and B, the terms "/and " it is to describe another affiliated partner relationship, indicate may exist two kinds of relationships, for example, A/ and B, can indicate: individually depositing In A, two kinds of situations of individualism A and B, in addition, character "/" herein, typicallying represent forward-backward correlation object is a kind of "or" pass System.
Embodiment one
Cream is smeared for treating hemorrhoid dai medicine provided by the present embodiment, by weight, including 20~50 parts of iron Three-coloured amaranth, 10~80 parts of hedgehog thorn, 10~50 parts of rhizoma cimicifugae dahuricae, 50~200 parts of paris polyphylla, 10~90 parts of borneol, 20~60 parts of the sophora bud, 10~50 parts of Moschus, 10~20 parts of the root bark of tree peony, 8~15 parts of radix paeoniae rubra, 10~25 parts of Pu Gonghuang, 5 ~10 parts of peach kernel, 10~25 parts of smilax, 2~8 parts of the root of Dahurain angelica and 100~500 parts of paste substrate.
The pharmacological action of constituent of the invention is specifically explained below:
Acalypha copperleaf is used as medicine with herb or aerial part, is had effects that clearing heat and detoxicating, dampness removing disperse accumulation and astringing to arrest bleeding, is used for Treat enteritis, hematochezia and carbuncle furuncle sore.It utilizes and has the effect of its clearing heat and detoxicating and astringing to arrest bleeding to hematochezia brought by hemorrhoid There is good therapeutic effect.
Hedgehog thorn, it is bitter in taste, sweet, flat, have effects that blood-activating analgetic and astringing to arrest bleeding, under major function hematochezia, intestines wind Blood, anal fistula and rectal prolapse, upper layer thorn mainly contain keratin, and lower dermis layer mainly contains Collagen scleroprotein, fat etc..I.e. hedgehog pierces The drug effect for the treatment of hemorrhoid can not only be reached by treatment hematochezia, while also having effects that analgesic, patient's body can be slowed down Suffer from the pain of hemorrhoid.
Rhizoma cimicifugae dahuricae is that the dry rhizome of plant Cimicifuga Dahurica also known as horse urinate bar, fiery cylinder bar, major function: rectal prolapse, carbuncle swells sore Poison etc..
Rhizoma cimicifugae dahuricae rhizome analog derivative containing triterpene, phenolic acid compound, saponin(e also containing alkaloids, cupreol and bitter taste Matter, while having containing ferulic acid, isoferulic acid, cimicifugoside etc., mentioned component has following pharmacological action: (1) solving thermal detoxification; (2) anti-inflammatory and antalgic, anti-inflammatory of reducing swelling, can reduce the area of anal ulcer.
Paris polyphylla is the plant of Liliaceae Paris, has effects that clearing heat and detoxicating, swelling and pain relieving, can slow down hemorrhoid Pain brought by sore.
The main component of borneol are as follows: the crystallization obtained from the resin and volatile oil of kapur is almost pure dextrorotation Borneol, containing there are many ter penoids in the resin and volatile oil of kapur.In addition to borneol, still contain Humuleno, beta-elemene, China pink The sequiterpenes such as alkene, the triterpenes such as oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol Compound.The effect of borneol, which has, leads to all keys, dissipates stagnated fire, goes screen improving eyesight, swelling and pain relieving, apoplexy lockjaw is cured mainly, pyreticosis coma is shied Epilepsy phlegm confusing heart, deafness with qi stagnation, sore throat, aphtha, tympanitis, carbuncle swells, hemorrhoid, mesh also screen film, enterobiasis etc..It has hemorrhoid preferable Curative effect, and pain brought by hemorrhoid can be slowed down.
Sophora bud broad sense is the dry flower and flower of leguminous plant Chinese scholartree, and cold nature, bitter have relax bowel and defecation, blood-stanching and blood-cooling The effect of, cure mainly the illnesss such as hematochezia, hemorrhoid blood, hematuria, sore.
Moschus external application can ease pain and reduce swelling, and when treating sore, Moschus of adding some points in medicine, and drug effect is particularly evident.
By above-mentioned design, using the Chinese medicines such as acalypha copperleaf, hedgehog thorn, rhizoma cimicifugae dahuricae, paris polyphylla, borneol and sophora bud original Material can have preferable therapeutic effect to hemorrhoid.
In addition, also containing the root bark of tree peony, radix paeoniae rubra, Pu Gonghuang, peach kernel, smilax and the root of Dahurain angelica, these raw materials in raw material of the invention As adjuvant drug, wherein the root bark of tree peony and radix paeoniae rubra have effects that clearing heat and cooling blood, activating microcirculation and removing stasis medicinal, and Pu Gonghuang has clearing heat and detoxicating Effect, peach kernel have effects that promoting blood circulation and relax bowel and defecation, smilax have detoxicating functions, and the root of Dahurain angelica has the function of apocenosis of invigorating blood circulation Effect, by adding above-mentioned raw materials in the present invention, so that the present invention has effects that dehumidification swelling, clearing heat and detoxicating, promoting blood circulation to remove blood stasis, Hemorrhoid can be eradicated in terms of clearing heat and detoxicating, promoting blood circulation scattered silt, the further present invention that improves is to the therapeutic effect of hemorrhoid.
In the present embodiment, paste substrate is the carrier of Chinese medicine, after capable of mixing with medicament, is coated on material of mounting and makes The exterior-applied formulation obtained.
In the present embodiment, citing paste substrate can with but be not limited only to vaseline, Babu plaster or polyethylene glycol 400, meanwhile, in the present embodiment, practical paste substrate of illustrating is Babu plaster, and Babu plaster has drugloading rate big, especially suitable For Chinese medical concrete, and skin good biocompatibility is ventilative, sweat proof, quick, non-stimulated without growing, and medicine-releasing performance is good, uses It is convenient, do not pollute clothes.
In conclusion smearing cream provided by the present invention for treatment hemorrhoid dai medicine, used Chinese medicine material meets Pharmacopoeia of People's Republic of China regulation, medicine source is safe and reliable, without any toxicity and side effects, it is good to the therapeutic effect of hemorrhoid and to human body without Evil, simultaneously, moreover it is possible to using the analgesic in Chinese medicine material, analgesic efficacy, mitigate hemorrhoid to patient's bring pain, alleviate patient's Pain.
Embodiment two
Provided by the present embodiment for treat hemorrhoid dai medicine smear cream and embodiment one the difference is that: wrapped The range of the content of each component contained is reduced relative to embodiment one.
Cream is smeared for treating hemorrhoid dai medicine provided by the present embodiment, by weight, including 20~45 parts of iron Three-coloured amaranth, 10~70 parts of hedgehog thorn, 10~45 parts of rhizoma cimicifugae dahuricae, 50~180 parts of paris polyphylla, 10~80 parts of borneol, 20~50 parts of the sophora bud, 10~45 parts of Moschus, 10~18 parts of the root bark of tree peony, 8~13 parts of radix paeoniae rubra, 10~23 parts of Pu Gonghuang, 5 ~9 parts of peach kernel, 10~23 parts of smilax, 2~7 parts of the root of Dahurain angelica and 100~450 parts of paste substrate.
In the present embodiment, the range for smearing each component content in cream for treating hemorrhoid dai medicine is changed, is made The content of each component is more accurate, it can be seen that the treatment hemorrhoid smear cream with dai medicine, and there is more obvious treatment to imitate Fruit.
Embodiment three
Treatment hemorrhoid provided by the present embodiment with dai medicine smear cream and embodiment two the difference is that: it is further Reduce the content that treatment hemorrhoid dai medicine smears each component in cream.
Treatment hemorrhoid provided by the present embodiment smear cream with dai medicine, including 20~35 parts of acalypha copperleafs, 10~50 parts Hedgehog thorn, 10~35 parts of rhizoma cimicifugae dahuricae, 50~140 parts of paris polyphylla, 10~60 parts of borneol, 20~40 parts of the sophora bud, 10~35 parts of Moschus, 12~16 parts of the root bark of tree peony, 8~11 parts of radix paeoniae rubra, 10~18 parts of Pu Gonghuang, 5~8 parts of peach kernel, 10 ~18 parts of smilax, 3~6 parts of the root of Dahurain angelica and 100~400 parts of paste substrate.
In the present embodiment, further reduce the content of each component, it can be seen that the present invention has more hemorrhoid Apparent therapeutic effect.
Example IV
The present embodiment relative to embodiment one the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group That divides determines value containing measurement.
The treatment hemorrhoid of offer described in the present embodiment smear cream with dai medicine, by weight, including 30 parts of acalypha copperleafs, 40 Hedgehog thorn, 20 parts of the rhizoma cimicifugae dahuricae, 120 parts of paris polyphylla, 50 parts of borneol, 25 parts of the sophora bud, 30 parts of Moschus, 15 of part The root bark of tree peony, 10 parts of radix paeoniae rubra, 15 parts of Pu Gonghuang, 6 parts of peach kernel, 15 parts of smilax, 5 parts of the root of Dahurain angelica and 350 parts of cream of part Agent matrix.
Embodiment five
The present embodiment relative to embodiment one the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group The maximum value in content Example one divided.
Treatment hemorrhoid provided by the present embodiment smear cream with dai medicine, by weight, including 50 parts of acalypha copperleafs, 80 parts Hedgehog thorn, 50 parts of rhizoma cimicifugae dahuricae, 200 parts of paris polyphylla, 90 parts of borneol, 60 parts of the sophora bud, 50 parts of Moschus, 20 parts The root bark of tree peony, 15 parts of radix paeoniae rubra, 25 parts of Pu Gonghuang, 10 parts of peach kernel, 25 parts of smilax, 8 parts of the root of Dahurain angelica and 500 parts of paste Matrix.
Embodiment six
The present embodiment relative to embodiment one the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group The median in content Example one divided.
The treatment hemorrhoid of offer described in the present embodiment smear cream with dai medicine, by weight, including 35 parts of acalypha copperleafs, 45 Hedgehog thorn, 30 parts of the rhizoma cimicifugae dahuricae, 125 parts of paris polyphylla, 50 parts of borneol, 40 parts of the sophora bud, 30 parts of Moschus, 15 of part Part the root bark of tree peony, 11.5 parts of radix paeoniae rubra, 17.5 parts of Pu Gonghuang, 7.5 parts of peach kernel, 17.5 parts of smilax, 5 parts of the root of Dahurain angelica and 300 parts of paste substrate.
Embodiment seven
The present embodiment relative to embodiment one the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group The minimum value in content Example one divided.
The treatment hemorrhoid of offer described in the present embodiment smear cream with dai medicine, by weight, including 20 parts of acalypha copperleafs, 10 Hedgehog thorn, 10 parts of the rhizoma cimicifugae dahuricae, 50 parts of paris polyphylla, 10 parts of borneol, 20 parts of the sophora bud, 10 parts of Moschus, 10 of part The root bark of tree peony, 8 parts of radix paeoniae rubra, 10 parts of Pu Gonghuang, 5 parts of peach kernel, 10 parts of smilax, 2 parts of the root of Dahurain angelica and 100 parts of paste of part Matrix.
Embodiment eight
The present embodiment relative to embodiment two the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group The maximum value in content Example two divided.
Treatment hemorrhoid provided by the present embodiment smear cream with dai medicine, by weight, including 45 parts of acalypha copperleafs, 70 parts Hedgehog thorn, 45 parts of rhizoma cimicifugae dahuricae, 180 parts of paris polyphylla, 80 parts of borneol, 50 parts of the sophora bud, 45 parts of Moschus, 18 parts The root bark of tree peony, 13 parts of radix paeoniae rubra, 23 parts of Pu Gonghuang, 9 parts of peach kernel, 23 parts of smilax, 7 parts of the root of Dahurain angelica and 450 parts of paste Matrix.
Embodiment nine
The present embodiment relative to embodiment two the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group The median in content Example two divided.
The treatment hemorrhoid of offer described in the present embodiment with dai medicine smear cream, by weight, including 32.5 parts of acalypha copperleafs, 40 parts of hedgehog thorn, 27.5 parts of rhizoma cimicifugae dahuricae, 115 parts of paris polyphylla, 45 parts of borneol, 35 parts of the sophora bud, 27.5 parts Moschus, 14 parts of the root bark of tree peony, 10.5 parts of radix paeoniae rubra, 16.5 parts of Pu Gonghuang, 7 parts of peach kernel, 16.5 parts of smilax, 4.5 parts The root of Dahurain angelica and 275 parts of paste substrate.
Embodiment ten
The present embodiment relative to embodiment two the difference is that: by the treatment hemorrhoid with dai medicine smear cream in each group The minimum value in content Example two divided.
The treatment hemorrhoid of offer described in the present embodiment smear cream with dai medicine, by weight, including 20 parts of acalypha copperleafs, 10 Hedgehog thorn, 10 parts of the rhizoma cimicifugae dahuricae, 50 parts of paris polyphylla, 10 parts of borneol, 20 parts of the sophora bud, 10 parts of Moschus, 10 of part The root bark of tree peony, 8 parts of radix paeoniae rubra, 10 parts of Pu Gonghuang, 5 parts of peach kernel, 10 parts of smilax, 2 parts of the root of Dahurain angelica and 100 parts of paste of part Matrix.
Embodiment 11
The preparation method that treatment hemorrhoid dai medicine smears cream is present embodiments provided, it is unlike the embodiments above to be in In: the detailed preparation method for giving the treatment hemorrhoid dai medicine and smearing cream of the present embodiment.
The treatment hemorrhoid provided by the present embodiment smear the preparation method of cream with dai medicine, comprising the following steps:
S101. appropriate acalypha copperleaf, hedgehog thorn, rhizoma cimicifugae dahuricae, paris polyphylla, borneol and the sophora bud are crushed respectively, has been crushed It after complete and is mixed, obtains raw material powder A after mixing.
In the present embodiment, the effect of the step S101 is to crush above-mentioned Chinese medicine material, and after mixing, so as to Carry out lower step processing.
S102. the appropriate root bark of tree peony, radix paeoniae rubra, Pu Gonghuang, peach kernel, smilax and the root of Dahurain angelica are crushed respectively, is gone forward side by side after crushing completely Row mixing, obtains raw material powder B after mixing.
Meanwhile the effect of step S102 is identical as the effect of step S101, does not add to repeat herein.Simultaneously by the root bark of tree peony, red Chinese herbaceous peony, Pu Gonghuang, peach kernel, smilax and the root of Dahurain angelica separate powder with acalypha copperleaf, hedgehog thorn, rhizoma cimicifugae dahuricae, paris polyphylla, borneol and the sophora bud Broken reason are as follows: obtained raw material powder A and raw material powder B have different processing method and processing conditions.
S103. Moschus is crushed, obtains Moschus fine powder.
The effect of the step S103 is to crush Moschus, to carry out more uniform mixing with various raw materials, so as to Moschus is set to reach the function of increasing drug effect.
S104. the ethyl alcohol that concentration is 80% is added into the raw material powder A, after mixing evenly, is obtained after impregnating 100~500h To mixture C.
In the present embodiment, the effect of the step S104 is, by ethanol extraction method, to extract the drug in raw material powder A Ingredient.
S105. the ethyl alcohol that concentration is 40% is added into the raw material powder B, after mixing evenly, is obtained after impregnating 100~300h To mixture D.
Meanwhile the effect of step S105 is identical as step S104, only raw material powder B is carrying out drug using ethanol extraction method When constituents extraction, the concentration and volume of required ethyl alcohol are different from raw material powder A, this is because what the characteristic of Chinese medicine material was determined.
S106. mixture C and mixture D are individually filtered respectively, obtain filtrate E and filtrate F.
S107. after ethyl alcohol being removed in filtrate D and filtrate F decompression volatilization respectively, medicinal extract G and medicinal extract H are obtained.
In the present embodiment, step S106 and step S107 is the subsequent processing of ethanol extraction method, enough when having impregnated After the long time, drug ingedient has been extracted, and is filtered at this time with regard to needing and is removed ethyl alcohol, pure convenient for obtaining Net drug ingedient, i.e. medicinal extract G and medicinal extract H.
S108. medicinal extract G is mixed with medicinal extract H, obtains semi-finished product I after mixing evenly.
In the present embodiment, the effect of the step S108 is to carry out the drug ingedient of the different Chinese medicine material of two batches Mixing, to make the smearing cream of support that there is better therapeutic effect.
S109. it is heated after appropriate paste substrate being added to semi-finished product I, after heating, is kept the temperature, then obtain paste J。
The effect of the step S109 are as follows: Chinese medicine ingredient is uniformly mixed by paste substrate, makes Chinese medicine Ingredient has certain viscosity, smears convenient for patient.
S110. after paste J is cooling, Moschus fine powder is added into paste J, is evenly stirred until solidification shape, can be obtained State described in any one it is a kind of treat hemorrhoid dai medicine smear cream.
The effect of the step S110 are as follows: Moschus fine powder is added, increases therapeutic effect of the invention.
In the present embodiment, " suitable " is those skilled in the art when carrying out smearing cream production, is made when adding drug Standard content.
Optimization, the crushing mesh number in the step S101 and the step S102 is between 250~400 mesh, institute The crushing mesh number of Moschus in step S103 is stated also between 250~400 mesh.By above-mentioned design, it can guarantee that each Chinese medicine is former Broken sufficiently fine of feed powder, convenient for more uniform mixing.
Optimization, ethyl alcohol and the mass ratio of raw material powder A are 10:1 in the step S104.It by above-mentioned design, can be most That changes greatly extracts the effective ingredient in raw material powder A, guarantees that the smearing cream prepared has preferable treatment effect to hemorrhoid Fruit.
Optimization, the mass ratio of the Central Plains step S105 feed powder B and ethyl alcohol is 1:8.Similarly, pass through optimal quality Than that can reach the maximized extraction effect of active drug ingredient in raw material powder B, guarantee that the smearing cream prepared has hemorrhoid There is preferable therapeutic effect.
Optimization, in the step S109, heating temperature is between 100~150 DEG C, and soaking time is between 1~2.5h Between.By above-mentioned design, paste substrate can be made uniformly to mix with Chinese medicine ingredient, and makes the effect of paste substrate most Bigization.
Embodiment 12
The present embodiment and embodiment 11 the difference is that: each step gives specific parameter when producing, and each Kind raw material gives concrete content.
The treatment hemorrhoid provided by the present embodiment smear the preparation method of cream with dai medicine, comprising the following steps:
S101. by 30 portions of acalypha copperleafs, 40 parts of hedgehog thorns, 20 parts of rhizoma cimicifugae dahuricaes, 120 portions of paris polyphyllas, 50 parts of borneols and 2 parts The sophora bud is crushed to 300 mesh respectively, after crushing completely and is mixed, obtains raw material powder A after mixing.
S102. 15 parts of root barks of tree peony, 10 parts of radix paeoniae rubras, 15 parts of Pu Gonghuang, 6 parts of peach kernels, 15 portions of smilaxs and 5 parts of roots of Dahurain angelica are distinguished into powder Broken 300 mesh after crushing completely and is mixed, obtains raw material powder B after mixing.
S103. by Moschus powder to 300 mesh, Moschus fine powder is obtained.
S104. the ethyl alcohol that concentration is 80% is added into the raw material powder A, wherein ethyl alcohol and the mass ratio of raw material powder A are 12:1 impregnates after mixing evenly, obtains mixture C after 350h;
S105. the ethyl alcohol that concentration is 40% is added into the raw material powder B, wherein ethyl alcohol and the mass ratio of raw material powder B are 8:1 obtains mixture D after impregnating 250h after mixing evenly;
S106. mixture C and mixture D are individually filtered respectively, obtain filtrate E and filtrate F;
S107. after ethyl alcohol being removed in filtrate D and filtrate F decompression volatilization respectively, medicinal extract G and medicinal extract H are obtained;
S108. medicinal extract G is mixed with medicinal extract H, obtains semi-finished product I after mixing evenly;
S109. 350 parts of Babu plaster is added to semi-finished product I, is then heated to 120 DEG C, after heating, keeps the temperature 2h, Then paste J is obtained;
S110. after paste J is cooling, 30 parts of Moschus fine powders is added into paste J, is evenly stirred until solidification shape, can obtain Cream is smeared to a kind of hemorrhoid dai medicine for the treatment of described in above-mentioned any one.
It is found through inventor's long-term experiment, when each process parameter setting is such as the present embodiment, the drug ingedient of raw material is mentioned Taken amount is maximum, and the therapeutic effect of hemorrhoid is best, is to prepare optimum process selection of the invention.
Experimental data:
The smearing cream for being used to treat hemorrhoid prepared by the present invention is used for clinical verification, it is of the invention to hemorrhoid to verify The validity of sore treatment.
350 patients are randomly divided into 7 groups first, every group of 50 people are respectively named as one group, two groups, three groups ... seven Group, wherein to be respectively corresponded for treating the smearing cream of hemorrhoid to one group to seven groups use prepared by example IV to ten, I.e. one group uses smearing cream prepared by example IV, and so on, it is used continuously 3 months, observes and records treatment condition, and In the therapeutic effect occurred in every group of whole patient, the identical therapeutic effect for choosing 80% is used as record therapeutic effect, and It was recorded respectively at 15 days, 30 days, 60 days and 90 days, (i.e. in every group of 50 patients, after using the present invention, there is 40 diseases The identical clinical therapeutic efficacy that people occurs simultaneously is recorded this as record therapeutic effect, to show that the present invention is right The therapeutic effect of hemorrhoid), calculating cure rate is completely disappeared with hemorrhoid clinical symptoms.
Realize that data are as shown in table 1 below:
1 therapeutic effect of table record figure
As can be seen from Table 1, the therapeutic effect of example IV is best, can obviously cure hemorrhoid, and embodiment five, six, Eight, nine pairs of hemorrhoid treatings are effective, and the symptom of patient is made also to be improved, and embodiment seven and embodiment ten are to the therapeutic effect of hemorrhoid It is unobvious.
To sum up, best to the effect of hemorrhoid using each component content in example IV.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are various under the inspiration of the present invention The product of form, however, make any variation in its shape or structure, it is all to fall into the claims in the present invention confining spectrum Technical solution, be within the scope of the present invention.

Claims (10)

1. a kind of hemorrhoid dai medicine for the treatment of smears cream, it is characterised in that: by weight, including 20~50 parts of acalypha copperleafs, 10 ~80 parts of hedgehog thorn, 10~50 parts of rhizoma cimicifugae dahuricae, 50~200 parts of paris polyphylla, 10~90 parts of borneol, 20~60 parts The sophora bud, 10~50 parts of Moschus, 10~20 parts of the root bark of tree peony, 8~15 parts of radix paeoniae rubra, 10~25 parts of Pu Gonghuang, 5~10 parts Peach kernel, 10~25 parts of smilax, 2~8 parts of the root of Dahurain angelica and 100~500 parts of paste substrate.
2. a kind of hemorrhoid dai medicine for the treatment of according to claim 1 smears cream, it is characterised in that: by weight, including 20~45 parts of acalypha copperleaf, 10~70 parts of hedgehog thorn, 10~45 parts of rhizoma cimicifugae dahuricae, 50~180 parts of paris polyphylla, 10~ 80 parts of borneol, 20~50 parts of the sophora bud, 10~45 parts of Moschus, 10~18 parts of the root bark of tree peony, 8~13 parts of radix paeoniae rubra, 10~23 The Pu Gonghuang, 5~9 parts of peach kernel, 10~23 parts of smilax, 2~7 parts of the root of Dahurain angelica and 100~450 parts of paste substrate of part.
3. a kind of hemorrhoid dai medicine for the treatment of according to claim 2 smears cream, it is characterised in that: by weight, including 20~35 parts of acalypha copperleaf, 10~50 parts of hedgehog thorn, 10~35 parts of rhizoma cimicifugae dahuricae, 50~140 parts of paris polyphylla, 10~ 60 parts of borneol, 20~40 parts of the sophora bud, 10~35 parts of Moschus, 12~16 parts of the root bark of tree peony, 8~11 parts of radix paeoniae rubra, 10~18 The Pu Gonghuang, 5~8 parts of peach kernel, 10~18 parts of smilax, 3~6 parts of the root of Dahurain angelica and 100~400 parts of paste substrate of part.
4. a kind of hemorrhoid dai medicine for the treatment of according to claim 3 smears cream, it is characterised in that: by weight, including 30 parts of acalypha copperleaf, 40 parts of hedgehog thorn, 20 parts of rhizoma cimicifugae dahuricae, 120 parts of paris polyphylla, 50 parts of borneol, 25 parts of Chinese scholartree Rice, 30 parts of Moschus, 15 parts of the root bark of tree peony, 10 parts of radix paeoniae rubra, 15 parts of Pu Gonghuang, 6 parts of peach kernel, 15 parts of smilax, 5 parts The root of Dahurain angelica and 350 parts of paste substrate.
5. treatment hemorrhoid described in any one smear cream with dai medicine according to claim 1~4, it is characterised in that: the paste Matrix is vaseline, Babu plaster or polyethylene glycol 400.
6. a kind of preparation method treated hemorrhoid dai medicine and smear cream, is used to prepare described in Claims 1 to 4 any one and controls It treats hemorrhoid and smears cream with dai medicine, which comprises the following steps:
S101. appropriate acalypha copperleaf, hedgehog thorn, rhizoma cimicifugae dahuricae, paris polyphylla, borneol and the sophora bud are crushed respectively, after crushing completely And mixed, raw material powder A is obtained after mixing;
S102. the appropriate root bark of tree peony, radix paeoniae rubra, Pu Gonghuang, peach kernel, smilax and the root of Dahurain angelica are crushed respectively, after crushing completely and is mixed It closes, obtains raw material powder B after mixing;
S103. Moschus is crushed, obtains Moschus fine powder;
S104. the ethyl alcohol that concentration is 80% is added into the raw material powder A, after mixing evenly, is mixed after impregnating 100~500h Close object C;
S105. the ethyl alcohol that concentration is 40% is added into the raw material powder B, after mixing evenly, is mixed after impregnating 100~300h Close object D;
S106. mixture C and mixture D are individually filtered respectively, obtain filtrate E and filtrate F;
S107. after ethyl alcohol being removed in filtrate D and filtrate F decompression volatilization respectively, medicinal extract G and medicinal extract H are obtained;
S108. medicinal extract G is mixed with medicinal extract H, obtains semi-finished product I after mixing evenly;
S109. it is heated after appropriate paste substrate being added to semi-finished product I, after heating, is kept the temperature, then obtain paste J;
S110. after paste J is cooling, Moschus fine powder is added into paste J, is evenly stirred until solidification shape, can be obtained such as right It is required that a kind of described in 1~4 any one treat hemorrhoid dai medicine smearing cream.
7. a kind of preparation method treated hemorrhoid dai medicine and smear cream according to claim 6, it is characterised in that: the step Crushing mesh number in rapid S101 and the step S102 is between 250~400 mesh, the crushing of Moschus in the step S103 Mesh number is also between 250~400 mesh.
8. a kind of preparation method treated hemorrhoid dai medicine and smear cream according to claim 6, it is characterised in that: the step Ethyl alcohol and the mass ratio of raw material powder A are 10:1 in rapid S104.
9. a kind of preparation method treated hemorrhoid dai medicine and smear cream according to claim 6, it is characterised in that: the step The rapid Central Plains S105 feed powder B and the mass ratio of ethyl alcohol are 1:8.
10. according to right ask 6 described in it is a kind of treat hemorrhoid dai medicine smear cream preparation method, it is characterised in that: the step In rapid S109, heating temperature is between 100~150 DEG C, and soaking time is between 1~2.5h.
CN201910577824.8A 2019-06-28 2019-06-28 It is a kind of to treat hemorrhoid dai medicine smearing cream and preparation method thereof Pending CN110123976A (en)

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Application publication date: 20190816