WO2003086435A1

WO2003086435A1 - Cleanser

Info

Publication number: WO2003086435A1
Application number: PCT/JP2002/003750
Authority: WO
Inventors: Tetsuo Santo; Songhua Li; Ruwei Wang; Sumio Iwasaki
Original assignee: Tetsuo Santo; Songhua Li; Ruwei Wang; Sumio Iwasaki
Priority date: 2002-04-15
Filing date: 2002-04-15
Publication date: 2003-10-23
Also published as: AU2002248030A1

Abstract

A cleanser comprising various plant extracts dissolved in water and causing no irritation pain or skin roughness which has a composition ratio by volume of from 2 to 6% of Sophorae Radix, from 1 to 3% of Phellodendri Cortex, from 1 to 3% of Coptidis Rhizoma, from 1 to 3% of Scutellariae Radix, from 1 to 3% of Stemona sessilifolia, from 1 to 3% of Rhei Rhizoma, from 1 to 3% of Punica granatum peel, from 1 to 3% of Paris polyphylla, from 1 to 3% of Flos chrysanthemi Indi and the balance of water.

Description

TECHNICAL FIELD The present invention relates to a detergent, and more particularly to a detergent which suppresses irritation to an affected part of a dermatitis patient such as an atopic dermatitis patient and does not cause detergent roughness. Background art

In recent years, the number of patients with atopic dermatitis has increased rapidly. These skin diseases are known as itching-related diseases, but they are characterized by the fact that they cause mental distress and worsen the symptoms of the disease, especially in infant patients. In this case, the patient is painful, not only for the parent but also for the close relatives.

To prevent or treat this skin disease, various countermeasures have been studied and implemented, but most of them are symptomatic treatments. In particular, antihistamines, antiallergic agents, anti-inflammatory drugs as symptomatic treatments in Western medicine Drugs and steroids were not satisfactory in terms of pharmacological effects and side effects. For example, antihistamines and antiallergic drugs have an antipruritic effect, but have a long-lasting effect and a problem with their anti-inflammatory effect. There are problems with long-term administration for chronic pruritus, as they may come.

In addition, steroids generally have high pharmacological effects, but may not be cured by long-term administration of steroids, have strong side effects unique to the drug, or reduce recoil due to discontinuation of steroid administration. However, there were problems such as the fact that the symptoms worsened.

In addition to the above-mentioned Western medical treatment, treatment with Chinese herbal medicine is also being performed. For example, as remedies for atopic dermatitis, It is composed of golden, yellow, gardenia, yellow leaf and toki, land yellow, gypsum, windbreak, burdock, mokudori, tomo, sesame, cicada retreat, and butterflies. These are vital blood stasis, which improves circulation and stops pain. Each is a symptomatic treatment that addresses individual symptoms, so it is hardly a fundamental therapeutic drug.

Therefore, although any ointment containing Chinese herbs has been made, it is a so-called symptomatic treatment, far from the fundamental treatment by improving constitution.

In addition, although their effects are moderate, Kampo medicines aimed at suppressing the above-mentioned side effects have been proposed. For example, Japanese Unexamined Patent Publication (Kokai) No. 6-166629 proposes an atopic dermatitis ameliorating agent obtained by mixing Daishigo-to with Tokishakuyakusan.

Also, Japanese Patent Application Laid-Open No. Hei 8-3107979 discloses that one or two selected from the group consisting of linden, lemonbaum, fenugreek, rurichsha, sodukiyu, deer horseshoe, large green grass, drizzled bean, and firamisai An external preparation for atopic dermatitis containing an extract of more than one plant as an active ingredient has also been proposed.

However, although topical preparations for atopic dermatitis have a certain antipruritic effect and disease improvement effect when applied to the affected area, they usually use a normal detergent to wash away so-called stains on the affected area. There was a problem that the affected part was irritated by the components contained in the skin, causing irritation pain and severe pruritus.

Accordingly, an object of the present invention is to provide a detergent that not only does not stimulate the affected area of various dermatitis such as Aatby dermatitis, but also has a therapeutic effect on atopic dermatitis and the like. Things. DISCLOSURE OF THE INVENTION The detergent of the present invention comprises a plant extract of Bitter ginseng, Huangkashia, Oriental, Huanghua, Hundred, Tochidaihoshi, Pomegranate skin, One-leaf flower of Seven-leaf flower and Wild chrysanthemum to solve the above problems. It is characterized by the following (claim 1).

Here, the family, main components and main effects of each of the above plant extracts will be described. (1) Sophia fLavescens Ait.

Botanical: Leguminosae Plant '

Active ingredient: Matorine urarmore.

Main effects: antibacterial, antiviral, antiallergic.

(2) Fahelloden ^ iron amurense Rupr.

Botanicals: Rutaceae Plant.

Active ingredient: Berbrme, Phellodendonne.

Main action: antibacterial, anti-inflammatory.

(3) Coptis Cbineneis Francli.

Botanical: Rwmnculaceae Plant. King component: Berberne, Coptisme, Ferulic acid.

Main effects: antibacterial, antiviral, anti-inflammatory.

(4) Osugon (Scutellaria baicalensis Geogij

Botanical Family: Labiatae Plant.

King ingredient: Baicalin, Baicalem.

Main effects: antibacterial, antiviral, antiallergic.

(5) Hyatab [Stemona sessilifolia (Mig.)]

Botanicals: Stemonaseae Plant.

King: Stemonine, Sessilistemomne.

Main effects: antibacterial, antiviral, antiallergic, insecticidal.

(6) Rbeum franzenbachii munt. Plant family: Polygonannceae plant .;

King Ingredient: Rhaponticin, Emocun.

Main effects: antibacterial, anti-itch.

(7) Pomegranate peel (Punica granat m L.)

Botanical: Pomegranate (Pxmicacea Plant.)

Active ingredient: Tannin, Mucus, Bitter taste

Main action: antibacterial, antifungal, antiviral, anti-inflammatory.

(8) Seven leaf single branch flower (Paris polyphyUa Sm.) Botanical Family: Liliaceae Plant.

King ingredient: Steroid saponin.

Main effects: antibacterial, anti-allergic, detoxification.

() Wild Chrysanthemum (Chrysanthemum inndic m L.)

Botanical: Compositac Plant.

Active ingredient: Volatile Oil. Trace element.

Main effects: Antibacterial, 'anti-inflammatory.

According to the above detergent, even if the affected part of an atopic dermatitis patient is washed, not only the affected part can be kept clean without irritating the affected part, but also the antibacterial action common to all plant extracts. Antiviral action common to Bitter ginseng, Orchid, Huanghua, Hundred part, Pomegranate peel, Anti-allergic action common to Bitter ginseng, Huangli, Hundred part, Seven leaf single flower, Huangkashi, Orenil, Pomegranate peel The anti-inflammatory action common to wild chrysanthemums, the antifungal action of pomegranate peel, the insecticidal action of one hundred parts, the detoxification action of one-leaf flower of seven leaves, and the anti-itch action of earth rhubarb, or the antibacterial effect described above, The anti-viral, anti-allergic, anti-inflammatory, anti-fungal, insecticidal, detoxifying and antipruritic effects are synergistically effective in treating the affected area. In the present invention, each of the plant extracts is dissolved in water, and the volume ratio of the extract is 2 to 6%, Bamboo shoot 1 to 3%, Huanghua 1 to 3%, Oren 1 to 3%, Yellow 1 to 3%, and 100%. 1 to 3%, 1 to 3% of soil, 1 to 3% of pomegranate, 1 to 3% of pomegranate, 1 to 3% of seven leaves and 1 to 3% of wild flowers, and 1 to 3% of wild chrysanthemum (Claim 2) .

If it is less than 2%, the desired effect is not obtained, and if it exceeds 6%, it may cause irritation, swelling of the skin, or rustiness. If it is less than 1 ° / ₀ , the intended effect will not be obtained. If it exceeds 3%, it may cause irritation, swelling of the skin, or rustiness. If it is less than 1%, the intended effect is not obtained, and if it exceeds 3%, it may cause irritation, swelling and redness of the skin. If it is less than 1%, the intended effect will not be obtained, and if it exceeds 3%, it may cause irritation, swelling of the skin, or rustiness. If it is less than 1%, the intended effect is not obtained, and if it exceeds 3%, it may cause irritation, redness and swelling of the skin. Earth white yellow 1% If it is less than 3%, the intended effect will not be obtained. If it exceeds 3%, it may cause irritation, swelling of the skin, and rashiness. If the pomegranate peel is less than 1%, the intended effect is not obtained, and if it exceeds 3%, irritant pain may occur, and the skin may become red and swollen or lumpy. If the rate is less than 1%, the desired effect cannot be obtained. If it exceeds 3%, irritant pain may occur. If the percentage of wild chrysanthemum is less than 1%, the desired effect is not obtained. If it exceeds 3%, irritation may occur, and the skin may become red, swollen, or dry.

According to the above-mentioned detergents, the action of each plant extract is well-balanced and not only can be washed and cleaned without irritating the affected area such as atopic dermatitis, but also the therapeutic effect is improved. Also have. In the present invention, the volume ratio of each component is 4% for bittersweet, 2% for Huangbai, 2% for oren, 2% for yellow, 2% for 100 parts, 2% for soda, 2 for pomegranate. 2 7% of one-leaf flower, wild chrysanthemum 2 In particular, the water content is 80% (claim 3).

According to the above-mentioned detergents, the balance of each plant extract is maximized, the synergistic effect of the extracts is maximized, there is no irritation to the affected area, and a very high therapeutic effect is obtained. Can be. BEST MODE FOR CARRYING OUT THE INVENTION Plants of Bitter ginseng, Huangkashia, Oren, Huanglian, Huangbu, Hyakubu, Tsuchidaihuang, Pomegranate skin, Seven-leaf single-flowered flowering plant and wild chrysanthemum are boiled or water-blanched. , Extract each extract, and make the volume ratio of each extracted extract to be 4% for bittersweet, 2% for Huangkashia, 2% for oren, 2% for yellow, 2% for 100 parts, 2% for soda and 2% for pomegranate Detergents were prepared with 2% of seven leaves, 2% of wild chrysanthemums and 80% of water.

This detergent is used for atopic dermatitis patients to wash affected areas with atopic symptoms on the face, trunk, lower abdomen, hands, feet, etc.The affected area can be washed and the affected area can be kept clean. Not only irritating pain to the affected area, but also Was able to improve the atopic symptoms in some areas. '' The detergent of the present invention has a therapeutic effect without stimulating the affected area of atopic dermatitis due to the medicinal components of the plant extract. ..Atopy dermatitis is cured, but if the symptoms are severe, for example, drinking the following drinking tea for the treatment of atopic dermatitis or applying a lotion or cream for treating atopic dermatitis to the affected area By using them together, a more excellent therapeutic effect can be obtained. Components and weight ratio of drinking tea for treatment of atopic dermatitis

The weight of each herbal extract extract per gram of powdered or granular drinking tea is 0.1 lg for bittersweet, 0.1 lg for large green leaves, and 0.02 g for keko. return 0. 0 5 g, Shirohanahebishitakusa 0. 1 _g, soil茯苓0. 1 2 g, chenpi 0. 0 5 g, wild chrysanthemum flower 0 · lg, Motoebisu 0. 0 2 _g, peppermint 0. O lg , Yellowish 0.05 g, purple grass 0.lg, kucho tea 0.05 _§ , tiger cane 0.lg and licorice 0.03 g. Ingredients and volume ratio of lotion for treating atby dermatitis

The volume ratio of each ingredient is 3% Bamboo, 2% Depressed Gold, 2% Thick, Peony 2%, Large Green Leaves 1%, Ice Fragment 1%, Yellow Bamboo 2%, White 1%, Lemon 3%, Tiger Stick 2%, Licorice 5%, Kawasaki 0.5%, Toki 0.5%, Salicylic acid 0.5%, Resorcin 0.5%, Alcohol 30%, Water 48.5% or

The volume ratio of each component is 3% Bamboo, 2% Depressed Gold, 2% Thick, Peony 2%, Large Green Leaves 1%, Ice Fragment 1%, Yellow Bamboo 2%, White 1%, Lemon 3%, Tiger Stick 2 %, Licorice 0.5%, dimethyl sulfoxide 5%, salicylic acid 0.5%, resorcin 0.5%, alcohol 26%, water 48.5 °

The volume ratio of each ingredient is 3% for Satsuma, 2% for Utsukin, 2% for Koboku, 2% for Peony, 1 for large green leaves. On ice pieces 1. /. , Yellow 2%, yellow 2%, white 1%, lemon 3%, tiger cane 1%, licorice 0.5%, Kawa 0.5%, Toki 0.5%, Salicylic acid 0.5%, Resorcinol 5%, Sheep oil 3%, Alcohol 3. White Waserin 70.5 / ₀ or

The volume ratio of each ingredient is 3% Bamboo, 2% Dessert 2%, Peony 2%, Large Green Leaves 1 ° / ₀ , Ice 1%, Yellow 2%, Yellow 2%, White 1%, Lemon 3%, Tiger stick 1%, Licorice 0.5%, Dimethyl sulfoxide 5%, Salicylic acid-0.5%, Resorcinol 0.5%, Sheep oil 3%, Alcohol 3%, White petrolatum 66.5% . The detergent of the present invention is characterized by containing a plant extract of Bitter ginseng, Huangkashia, Orchid, Huanghua, Hundred parts, Todaihuang, Pomegranate peel, Seven-leafed branch flower and Wild chrysanthemum flower. The antibacterial, antiviral, antiallergic, antiinflammatory, antifungal, and antipruritic effects of this component can clean the affected parts of dermatitis such as atopic dermatitis without irritation, and have a therapeutic effect. Short-term use and long-term use do not cause rash or other side effects.

Claims

The scope of the claims

1. A detergent comprising a plant extract of Bitter ginseng, Huangbai, Oren, Huang, Hundred parts, Dodai, Pomegranate peel, Seven-leafed flower and Wild chrysanthemum flower.

2. Each of the above plant extracts is dissolved in water, and their volume ratio is 2-6% for Bamboo, 1-3% for Huangkashia, 1-3% for Orian, 1-3% for yellow, 1 part for 1 part The detergent according to claim 1, wherein the detergent is 3%, soil white yellow 1 to 3%, pomegranate skin 1 to 3%, one-leaf flower of seven leaves 1 to 3%, wild chrysanthemum 1 to 3%, and residual water.

3. The volume ratio of each ingredient is Bitter ginseng 4%, Huangkashi 2%, Oren 2%, Yellow 2%, Hundred 2%, Dodai 2 ° / ₀ , Pomegranate skin 2%, Seven leaf single branch flower 2% A detergent comprising 2% wild chrysanthemum and 80% water.