JPH0327318A - Drug for allergic rhinitis - Google Patents
Drug for allergic rhinitisInfo
- Publication number
- JPH0327318A JPH0327318A JP1160917A JP16091789A JPH0327318A JP H0327318 A JPH0327318 A JP H0327318A JP 1160917 A JP1160917 A JP 1160917A JP 16091789 A JP16091789 A JP 16091789A JP H0327318 A JPH0327318 A JP H0327318A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- allergic rhinitis
- day
- freeze
- nasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940124449 drug for allergic rhinitis Drugs 0.000 title abstract description 3
- 206010039085 Rhinitis allergic Diseases 0.000 claims abstract description 8
- 201000010105 allergic rhinitis Diseases 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 5
- 239000000284 extract Substances 0.000 claims abstract description 5
- 241000208340 Araliaceae Species 0.000 claims description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 15
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 15
- 235000008434 ginseng Nutrition 0.000 claims description 15
- 230000000694 effects Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000000243 solution Substances 0.000 abstract description 3
- 206010028735 Nasal congestion Diseases 0.000 abstract description 2
- 239000007923 nasal drop Substances 0.000 abstract 2
- 241000246044 Sophora flavescens Species 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 12
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000007922 nasal spray Substances 0.000 description 4
- 229940097496 nasal spray Drugs 0.000 description 4
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 3
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 229930014456 matrine Natural products 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010044302 Tracheitis Diseases 0.000 description 2
- 206010001093 acute tonsillitis Diseases 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 230000003288 anthiarrhythmic effect Effects 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 1
- XVPBINOPNYFXID-JARXUMMXSA-N 85u4c366qs Chemical compound C([C@@H]1CCC[N@+]2(CCC[C@H]3[C@@H]21)[O-])N1[C@@H]3CCCC1=O XVPBINOPNYFXID-JARXUMMXSA-N 0.000 description 1
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- YKGCBLWILMDSAV-GOSISDBHSA-N Isoxanthohumol Natural products O(C)c1c2C(=O)C[C@H](c3ccc(O)cc3)Oc2c(C/C=C(\C)/C)c(O)c1 YKGCBLWILMDSAV-GOSISDBHSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010037596 Pyelonephritis Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 208000005448 Trichomonas Infections Diseases 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 206010044620 Trichomoniasis Diseases 0.000 description 1
- 229940039750 aconitine Drugs 0.000 description 1
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 201000009329 acute pericementitis Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000002223 anti-pathogen Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- LUHFBLPAWMYPDS-UHFFFAOYSA-N chloroform 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound ClC(Cl)Cl.CNCC(O)C1=CC=C(O)C(O)=C1 LUHFBLPAWMYPDS-UHFFFAOYSA-N 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- FUSADYLVRMROPL-UHFFFAOYSA-N demethylxanthohumol Natural products CC(C)=CCC1=C(O)C=C(O)C(C(=O)C=CC=2C=CC(O)=CC=2)=C1O FUSADYLVRMROPL-UHFFFAOYSA-N 0.000 description 1
- 208000021264 digitalis poisoning Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 201000006592 giardiasis Diseases 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 201000003265 lymphadenitis Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- -1 matrine Natural products 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 229930015582 oxymatrine Natural products 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- UVBDKJHYMQEAQV-UHFFFAOYSA-N xanthohumol Natural products OC1=C(CC=C(C)C)C(OC)=CC(OC)=C1C(=O)C=CC1=CC=C(O)C=C1 UVBDKJHYMQEAQV-UHFFFAOYSA-N 0.000 description 1
- ORXQGKIUCDPEAJ-YRNVUSSQSA-N xanthohumol Chemical compound COC1=CC(O)=C(CC=C(C)C)C(O)=C1C(=O)\C=C\C1=CC=C(O)C=C1 ORXQGKIUCDPEAJ-YRNVUSSQSA-N 0.000 description 1
- 235000008209 xanthohumol Nutrition 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
本発明は、アレルギー性鼻炎の治療薬に閲するものであ
る．The present invention relates to a therapeutic agent for allergic rhinitis.
長野県や中国河北省などで栽培されているマメ科（Ｌｅ
ｇｕｍｉｎｏｓａｅ）のクララ（Ｓｏｐｈｏｒａ ａｎ
ｇｕｓｔｉｆｏｌｉａ）の根を乾燥した苦参には、ｄ−
マトリン、ｄ−オキシマトリン、ｄ−ソフ才ラノーノレ
、トアナギリン、ｌ−メチルシチシン、ｌ−パブチホリ
ン、ｌ−ソフオカルピン等のアルカロイドや、キサント
フモール、インキサントフモール、３．４’ ，５−
｝リヒドロキシ−７−メトキシ−８−イソベンテニルフ
ラボン、８−インベンテニルゲンペロール等のフラボノ
イド類が含まれている．尚、茎と葉にはルテオリンー７
−グルコシドが含まれる．
そして、この苦参には次のような薬理作用があると言わ
れている．
１．利尿作用
苦参の煎剤及び苦参に含まれるマトリンをウサギに投与
もしくは注射すれば、利尿作用が現れる．２．抗不整脈
作用
総フラボンはクロロホルムの引き起こすマウス心室細動
に対抗し、クロロホルムーアドレナリンによるウサギの
不整脈に対抗する．またアコニチンによるラットの不整
脈に対する治療作用もある．静脈注射するとラットの心
拍数を減らし、大量に用いると心電図のＰ−Ｒ期を延長
する．オキシマトリンもアドレナリンによる不１１誠に
有効である．アルコール抽出物もジギタリス中毒からく
るラットの不整脈に対し良好な対抗作用がある．３．抗
病原体作用
アルコール抽出エキスはｉｎ ｖｉｔｙｊｏで抗トリコ
モナス作用をもち、その強度は黄連より弱く、蛇床子に
ほぼ等しい．
４．その他の作用
マトリンをウサギに注射すると、中枢神経の麻痺がみら
れ、同時に痙果を起こす．
そして、次のような治療に用いられると言われている．
１．４１１１性癖疾の治療
■ 内服法 ５０％の濃い煎剤を１回２０〜３０一ずつ
，１日３回服用する．あるいは苦参１００ｇに水４００
ｍｌを加え２００ｍｌになるまで煎じ、ｉ日２回に分け
て服用し、７〜１０を１クールとする．
■ 注射法 ５０％の注射液２〜４−を朝晩１回ずつ筋
肉注射する．
■潅腸法
■へそに貼る方法
２。急性腸胃炎の治療
煎じて１日２回服用する．又はシロップ剤を１回１０〜
１５−１ずつ，１日２回服用する．３．急性伝染性肝炎
の治療
一般的な肝機能保全の治療のほかに、苦参の粉末４ｇを
カプセルに詰めるか、あるいは丸剤にして１日４回に分
けて服用する．
４．小児肺炎の治療
２００％の苦参注射液２＋ｓＺを１日２回筋肉注射する
．
５．急性扁桃炎などの治療
５０％の苦参注射液を１回２〜３−ずつ、１日２回筋肉
注射して、急性雁桃炎、急性結膜炎、急性乳腺炎、歯周
炎、外科的感染と腎孟腎炎、急性気管炎、急性リンパ節
炎などの急性炎症性疾病を治療した例では、有効率９０
％以上、治癒率７４％以上であった．その他にも、大腸
炎、胆嚢炎、膀胱ゝ炎等の炎症に対してもかなりの効果
がある．６．慢性気管炎の治療
苦参７、桔硬３の割合で配合し、細かい粉末にし、水を
加えて丸剤にする．１日２回服用し、１０日を１クール
とする．次のクールへ移るときには５日あいだをおく．
７．ランブル鞭毛虫症の治療
８．腸トリコモナスの治療
苦参の粉末のカプセルもしくは錠剤を服用する．９．ト
リコモナス腟炎の治療
１０．住血吸虫病による腹水の治療
ところで、上記のように各種の治療に苦参が用いられて
いるものの、これまで苦参がアレルギー性鼻炎の治療に
用いられたとの報告はない．The legume family (Le) is cultivated in Nagano Prefecture and Hebei Province, China.
Guminosae) Clara (Sophora an
D-
Alkaloids such as matrine, d-oxymatrine, d-sophyllanol, toanagiline, l-methylcytisine, l-pabutifoline, l-sofuocarpine, xanthohumol, inxanthohumol, 3.4',5-
}Contains flavonoids such as rehydroxy-7-methoxy-8-isobentenylflavone and 8-inbentenylgenperol. In addition, the stems and leaves contain luteolin-7.
- Contains glucosides. This bitter ginseng is said to have the following pharmacological effects. 1. Diuretic effect When a decoction of bitter ginseng or matrine contained in bitter ginseng is administered or injected to rabbits, a diuretic effect appears. 2. Antiarrhythmic effects Total flavones counteract chloroform-induced ventricular fibrillation in mice and chloroform-adrenaline-induced arrhythmias in rabbits. Aconitine also has a therapeutic effect on arrhythmia in rats. When injected intravenously, it reduces the heart rate of rats, and when used in large doses, it prolongs the P-R phase of the electrocardiogram. Oxymatrine is also effective against adrenaline-induced anxiety. Alcohol extracts also have good anti-arrhythmia effects in rats caused by digitalis poisoning. 3. Anti-pathogen activity The alcohol extract has anti-trichomoniasis activity in vitro, and its strength is weaker than that of Oriental chinensis and almost equal to that of Jabedoko. 4. Other effects When matrine is injected into rabbits, paralysis of the central nervous system is observed, as well as convulsions. It is said to be used for the following treatments: 1.4111 Treatment of Sexual Addiction Disorder ■ Oral administration: Take 20 to 30 doses of a 50% strong decoction three times a day. Or 100g of bitter ginseng and 400g of water
ml, decoct until the total volume is 200 ml, and take it twice a day, with doses 7 to 10 being one course. ■ Injection method Inject 50% injection solution 2-4- intramuscularly once in the morning and evening. ■Enema method■Method of applying it to the navel 2. For the treatment of acute intestinal gastritis, take a decoction twice a day. Or syrup for 10~
Take 15-1 twice a day. 3. Treatment of Acute Infectious Hepatitis In addition to the general treatment to preserve liver function, take 4g of bitter ginseng powder in capsules or pills divided into four doses a day. 4. Treatment of childhood pneumonia: Inject 200% Kuginseng injection 2 + sZ intramuscularly twice a day. 5. Treatment of acute tonsillitis, etc. Inject 50% ginseng injection into the muscle twice a day at 2 to 3 doses at a time to treat acute tonsillitis, acute conjunctivitis, acute mastitis, periodontitis, and surgical infections. In cases where acute inflammatory diseases such as pyelonephritis, acute tracheitis, and acute lymphadenitis were treated, the efficacy rate was 90.
The cure rate was over 74%. It is also quite effective against inflammation such as colitis, cholecystitis, and cystitis. 6. Treatment of chronic tracheitis: Mix 7 parts of ginseng and 3 parts of ginseng, grind into a fine powder, add water and form into pills. Take twice a day, with 10 days as one course. Wait 5 days before moving on to the next course. 7. Treatment of Giardiasis 8. To treat Trichomonas intestinalis, take powdered ginseng capsules or tablets. 9. Treatment of Trichomonas vaginitis 10. Treatment of ascites caused by schistosomiasis By the way, although bitter ginseng has been used for various treatments as mentioned above, there have been no reports to date of bitter ginseng being used to treat allergic rhinitis.
本発明者は、苦参を煎じたものを凍結乾燥し、このもの
を例えば０．５〜５％の溶液にした点鼻剤をアレルギー
性鼻炎の患者の鼻腔に滴下した所、鼻閉、くしやみ、鼻
汁の抑制に効果があることを見出すに至った．
すなわち、アレルギー性鼻炎に対して１〜４週間の投与
により、軽快、改善が認められたのである．鼻閉につい
ては即効を呈することもあった．本発明は上記の知見を
基にして達成されたものであり、苦参の抽出物を含むこ
とを特徴とするアレルギー性鼻炎薬を提供するものであ
る．尚、このアレルギー性鼻炎薬は、点鼻剤タイプある
いは軟膏剤タイプのような如何なるタイプのものとして
も良い．The present inventor freeze-dried a decoction of bitter ginseng and made a 0.5-5% solution of this into a nasal spray that was dropped into the nasal cavity of a patient with allergic rhinitis. We have discovered that it is effective in suppressing nasal discharge. In other words, relief and improvement in allergic rhinitis was observed after administration for 1 to 4 weeks. In some cases, it had an immediate effect on nasal congestion. The present invention was achieved based on the above findings, and provides a drug for allergic rhinitis characterized by containing an extract of bitter ginseng. Note that this allergic rhinitis drug may be of any type, such as a nasal spray type or an ointment type.
苦参を煎じたものを凍結乾燥し、このもののｌ％の点鼻
剤を作成した．
そして、このようにして得られた点鼻剤を１日に２〜３
回アレルギー性鼻炎の患者の鼻腔に一滴滴下し、その治
療戊績は次の表に示す通りであった．A decoction of bitter ginseng was freeze-dried and a 1% nasal spray was prepared. Then, administer the nasal spray obtained in this way 2 to 3 times a day.
One drop was placed into the nasal cavity of a patient with allergic rhinitis, and the therapeutic results are shown in the table below.
Claims (1)
薬。An allergic rhinitis medicine characterized by containing an extract of bitter ginseng.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1160917A JPH07119175B2 (en) | 1989-06-26 | 1989-06-26 | Allergic rhinitis drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1160917A JPH07119175B2 (en) | 1989-06-26 | 1989-06-26 | Allergic rhinitis drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0327318A true JPH0327318A (en) | 1991-02-05 |
| JPH07119175B2 JPH07119175B2 (en) | 1995-12-20 |
Family
ID=15725101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1160917A Expired - Fee Related JPH07119175B2 (en) | 1989-06-26 | 1989-06-26 | Allergic rhinitis drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07119175B2 (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100384661B1 (en) * | 2000-12-18 | 2003-05-22 | 강삼식 | Anti-inflammatory prenylated flavonoid derivatives and extract of Sophora flavescens therewith |
| WO2003086434A1 (en) * | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Drinking tea for treating dermatitis |
| WO2003086435A1 (en) * | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Cleanser |
| KR100556286B1 (en) * | 2002-04-02 | 2006-03-03 | 전북대학교산학협력단 | Fabrication drink for medicinal plants |
| JP2008517999A (en) * | 2004-10-27 | 2008-05-29 | エスケー ケミカルズ カンパニー リミテッド | Bitter extract useful for prevention and treatment of respiratory diseases |
| JP2009208803A (en) * | 2008-03-03 | 2009-09-17 | Yoshio Watanabe | Sidewall bridging/closing bag |
| JP2013515054A (en) * | 2009-12-22 | 2013-05-02 | エイボン プロダクツ インコーポレーテッド | Paxillin stimulating composition and its use as a cosmetic |
| CN104083517A (en) * | 2014-07-17 | 2014-10-08 | 刘国勷 | Traditional Chinese medicine composition for treating perennial allergic rhinitis |
| US9687440B2 (en) | 2009-12-29 | 2017-06-27 | Avon Products, Inc | CGRP compositions and uses thereof |
-
1989
- 1989-06-26 JP JP1160917A patent/JPH07119175B2/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100384661B1 (en) * | 2000-12-18 | 2003-05-22 | 강삼식 | Anti-inflammatory prenylated flavonoid derivatives and extract of Sophora flavescens therewith |
| KR100556286B1 (en) * | 2002-04-02 | 2006-03-03 | 전북대학교산학협력단 | Fabrication drink for medicinal plants |
| WO2003086434A1 (en) * | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Drinking tea for treating dermatitis |
| WO2003086435A1 (en) * | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Cleanser |
| JPWO2003086434A1 (en) * | 2002-04-15 | 2005-08-18 | 哲夫 山東 | Drinking tea for dermatitis treatment |
| US7615239B2 (en) | 2002-04-15 | 2009-11-10 | Tetsuo Santo | Tea for treating dermatitis comprising herbal extracts |
| JP2008517999A (en) * | 2004-10-27 | 2008-05-29 | エスケー ケミカルズ カンパニー リミテッド | Bitter extract useful for prevention and treatment of respiratory diseases |
| JP2009208803A (en) * | 2008-03-03 | 2009-09-17 | Yoshio Watanabe | Sidewall bridging/closing bag |
| JP2013515054A (en) * | 2009-12-22 | 2013-05-02 | エイボン プロダクツ インコーポレーテッド | Paxillin stimulating composition and its use as a cosmetic |
| US9066896B2 (en) | 2009-12-22 | 2015-06-30 | Avon Products, Inc. | Paxillin stimulating compositions and cosmetic uses thereof |
| US9687440B2 (en) | 2009-12-29 | 2017-06-27 | Avon Products, Inc | CGRP compositions and uses thereof |
| CN104083517A (en) * | 2014-07-17 | 2014-10-08 | 刘国勷 | Traditional Chinese medicine composition for treating perennial allergic rhinitis |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07119175B2 (en) | 1995-12-20 |
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