CN102058833B

CN102058833B - Traditional Chinese medicine composition-type spray or aerosol and preparation method thereof

Info

Publication number: CN102058833B
Application number: CN2009102375684A
Authority: CN
Inventors: 刘丽颖; 郑松涛
Original assignee: 刘丽颖
Current assignee: Harbin Pugongying Pharmaceutical Co., Ltd.
Priority date: 2009-11-12
Filing date: 2009-11-12
Publication date: 2013-04-10
Anticipated expiration: 2029-11-12
Also published as: CN102058833A

Abstract

The invention discloses a traditional Chinese medicine composition-type spray or aerosol capable of reducing blood pressure, abating fever and resisting inflammation and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention contains 15 active pharmaceutical ingredients as below: artificial cow-bezoar, porcine gall powder, baikal skullcap root, curcuma root, cape jasmine, borneol, coptis root, pearl, hematite, realgar, cinnabar, mentha camphor, gypsum, concentrated powder of buffalo horn and nacre, the auxiliaries of the spray include solubilizing agent, diluting agent and cosolvent the aerosol further requires the addition of propellant; and the auxiliaries can further include one or more than one of flavoring agent, antiseptic, stabilizing agent and antioxidant. The preparation method of the traditional Chinese medicine composition-type spray or aerosol disclosed by the invention comprises the following steps: grouping the active pharmaceutical ingredients at first, preparing intermediate and medicinal powder respectively, mixing the intermediate with the medicinal powder, and adding the auxiliaries to the mixture according to routine technology to obtain the spray or the aerosol. Pharmacodynamic experiments show that the traditional Chinese medicine composition-type spray or aerosol, prepared according to the method disclosed by the invention, has the effects of abating fever, resisting inflammation, resisting thrombosis and reducing blood pressure.

Description

A kind of Traditional Chinese medicine composition-type spray or aerosol and preparation method thereof

Technical field

The present invention relates to a kind of medicinal composition spray or aerosol and preparation method thereof, particularly the Traditional Chinese medicine composition-type spray of a kind of blood pressure lowering, antipyretic and anti-inflammatory or aerosol and preparation method thereof.

Background technology

Annaowan bolus is the prescriptions of Chinese medicine that is recorded in the 13 77 pages of the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparations, standard number is WS3-B-2517-97, and the prescription of having put down in writing Annaowan bolus in the standard comprises: artificial Calculus Bovis, Pulvis Fellis Suis, Cinnabaris, Borneolum Syntheticum, Pulvis Cornus Bubali Concentratus, Margarita, Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Realgar, Radix Curcumae, Gypsum Fibrosum, Haematitum, Concha Margaritifera and Mentholum; The prescription consumption proportion relation of Annaowan bolus that the patent No. has been 93100258.3 Patent Application Publications, and conventional preparation technology; The open Annaowan bolus of available data has heat-clearing and toxic substances removing, refreshment and tranquilization, eliminates phlegm for resuscitation, the relieving convulsion effect that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and nowadays is hyperpyrexia, the delirious clinical application that a kind for the treatment of acute inflammation commonly used causes.

Yet, Annaowan bolus has existed for many years as the honeyed pill dosage form, by pulverizing, water flies, the simple and regular preparation technology that the steps such as refined honey form can't solve this prescription products all the time potential toxic and side effects, wastage of material is more, original causing of dosage form can not fully be absorbed by human body, take inconvenience, especially the medicine as a kind of refreshment and tranquilization can not be waited the patient that can not take care of oneself conveniently to take by paralysis, the problems referred to above exert an influence to the market prospect of this prescription products in the environment that nowadays tradition is write out a prescription and high-tech is combined closely, and simplify prescription, the improvement dosage form, improving preparation technology all is problem demanding prompt solutions that Annaowan bolus faces.

Summary of the invention

The object of the invention is to disclose Traditional Chinese medicine composition-type spray or the aerosol of a kind of blood pressure lowering, antipyretic and anti-inflammatory, the present invention also aims to disclose the preparation method of this spray or aerosol.

The present invention seeks to be achieved by the following scheme.

The crude drug of spray of the present invention or aerosol consists of:

Artificial Calculus Bovis 0.5-2 weight portion Pulvis Fellis Suis 7-20 weight portion Rhizoma Coptidis 5-15 weight portion

Radix Scutellariae 5-15 weight portion Margarita 1-5 weight portion Fructus Gardeniae 5-15 weight portion

Radix Curcumae 5-15 weight portion Haematitum 2-6 weight portion Realgar 3-9 weight portion

Cinnabaris 2-6 weight portion Mentholum 0.5-2 weight portion Gypsum Fibrosum 5-12 weight portion

Borneolum Syntheticum 0.5-4 weight portion Pulvis Cornus Bubali Concentratus 7-20 weight portion

Concha Margaritifera 2-8 weight portion.

The crude drug composition of spray of the present invention or aerosol is preferably:

Artificial Calculus Bovis's 1 weight portion Pulvis Fellis Suis 13 weight portion Rhizoma Coptidis 10 weight portions

Radix Scutellariae 10 weight portion Margaritas 3 weight portion Fructus Gardeniaes 10 weight portions

Radix Curcumae 10 weight portion Haematitums 4 weight portion Realgars 6 weight portions

Cinnabaris 4 weight portion Mentholums 1 weight portion Gypsum Fibrosum 8 weight portions

Borneolum Syntheticum 2 weight portion Pulvis Cornus Bubali Concentratuss 13 weight portion Concha Margaritiferas 5 weight portions.

Artificial Calculus Bovis's 0.7 weight portion Pulvis Fellis Suis 18 weight portion Rhizoma Coptidis 6 weight portions

Radix Scutellariae 14 weight portion Margaritas 2 weight portion Fructus Gardeniaes 14 weight portions

Radix Curcumae 6 weight portion Haematitums 5 weight portion Realgars 4 weight portions

Cinnabaris 5 weight portion Mentholums 0.7 weight portion Gypsum Fibrosum 11 weight portions

Borneolum Syntheticum 1 weight portion Pulvis Cornus Bubali Concentratus 18 weight portion Concha Margaritiferas 3 weight portions.

Artificial Calculus Bovis's 1.8 weight portion Pulvis Fellis Suiss 9 weight portion Rhizoma Coptidis 14 weight portions

Radix Scutellariae 6 weight portion Margaritas 4 weight portion Fructus Gardeniaes 6 weight portions

Radix Curcumae 14 weight portion Haematitums 3 weight portion Realgars 8 weight portions

Cinnabaris 3 weight portion Mentholums 1.8 weight portion Gypsum Fibrosum 6 weight portions

Borneolum Syntheticum 3.5 weight portion Pulvis Cornus Bubali Concentratuss 9 weight portion Concha Margaritiferas 7 weight portions.

The adjuvant of spray of the present invention consists of:

Solubilizing agent 50-180 weight portion

Diluent 350-1200 parts by volume

Cosolvent 80-220 weight portion.

The adjuvant of spray of the present invention consists of:

Solubilizing agent 120 weight portions

Diluent 800 parts by volume

Cosolvent 150 weight portions.

The adjuvant of spray of the present invention consists of:

Solubilizing agent 150 weight portions

Diluent 400 parts by volume

Cosolvent 100 weight portions.

The adjuvant of spray of the present invention consists of:

Solubilizing agent 80 weight portions

Diluent 1000 parts by volume

Cosolvent 200 weight portions.

The adjuvant of aerosol of the present invention consists of on the basis of above-mentioned spray and adds following adjuvant:

Propellant 50-350 weight portion; Preferably: 200 weight portions, 100 weight portions or 300 weight portions.

The adjuvant of spray of the present invention or aerosol forms can also add other conventional medicines again on the basis of above-mentioned adjuvant

Use adjuvant, comprise in the following adjuvant one or more:

Correctives 10-50 weight portion

Antiseptic 10-50 weight portion

Stabilizing agent 10-50 weight portion

Antioxidant 10-50 weight portion.

The adjuvant of spray of the present invention or aerosol forms the Optimization of Adjuvant that can also add again and comprises such as lower one or more:

Correctives 30 weight portions

Antiseptic 30 weight portions

Stabilizing agent 30 weight portions

Antioxidant 30 weight portions.

Correctives 45 weight portions

Antiseptic 15 weight portions

Stabilizing agent 15 weight portions

Antioxidant 45 weight portions.

Correctives 15 weight portions

Antiseptic 45 weight portions

Stabilizing agent 45 weight portions

Antioxidant 15 weight portions.

Wherein, above-mentioned solubilizing agent is one or more in Laurel Pyrusussuriensis gallbladder, Sorbitan Palmitate, sorbitan stearate, Sorbitan Tristearate, Sorbitan Oleate, sorbitan stearate, Sorbitan Tristearate, Sorbitan Oleate, Sorbitan Trioleate, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polyoxyethylene sorbitan monoleate, polysorbate 85, Myrj 52, paregal O, peregal A, Ai Moerfu, cetomacrogol, PLURONICS F87, poloxamer 237, sodium lauryl sulphate and the cetyltrimethylammonium base amine bromide.

Wherein, above-mentioned diluent is one or more in water, Diluted Alcohol, glycerol, propylene glycol, Polyethylene Glycol and the glycerol.

Wherein, above-mentioned cosolvent is one or more in Tween-60, tween 80, hexadecanol, octadecanol and the lecithin.

Wherein, above-mentioned correctives is one or more in orange syrup, Cortex cinnamomi japonici (Ramulus Cinnamomi) syrup, glycerol, sorbitol, mannitol, Folium Stevlae Rebaudianae, red bright alcohol, glucide, cyclamate, xylitol, aspartame, fructose, sucralose, Fructus Citri Limoniae, Herba Menthae Haplocalycis volatile oil, apple essence, flavoring banana essence, vinegar sultone potassium, contracting phenodiazine acidic group amide, agedoite, agedoite-vinegar sultone salt and the cyclohexyl sulfamic acid.

Wherein, the aforementioned stable agent is among a kind of or several in glycerol, Polyethylene Glycol, dextran, ethylenediaminetetraacetic acid, disodiumedetate and the sodium ethylene diamine tetracetate calcium.

Wherein, foregoing preservatives is one or more in sorbic acid, ethanol, benzyl alcohol, Nipagin ester, this alcohol of benzene second, benzalkonium chloride, methyl parahydroxybenzoate, benzyl alcohol, chlorobutanol, thimerosal, phenylmercuric nitrate, hibitane and the phenoxyethanol.

Wherein, above-mentioned antioxidant is among a kind of or several in vitamin C, sodium sulfite, sodium sulfite, cysteine, paddy cystine and the ascorbic acid.

Wherein, above-mentioned propellant is one or more in isceon, dichlorodifluoromethane, dichlorotetra-fluoroethane, tetrafluoroethane, heptafluoro-propane, propane, iso-butane and the normal butane.

The preparation method of spray of the present invention or aerosol comprises the steps:

Get the above-mentioned raw materials medicine, add conventional adjuvant according to common process and make intermediate, add again above-mentioned adjuvant and make spray of the present invention or aerosol.

Wherein, the described crude drug method of making intermediate can also be in the following method any one:

Technique 1: formed by following steps A, B, C, D and E

Steps A: preparation intermediate compound I

A1: with the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get the supernatant Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A2: with the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0 ~ 1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A3: with Radix Curcumae elder generation heating water reflux, extract, 2-4 time, 0.5-2.5 hour at every turn, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get the supernatant Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A4: with Radix Curcumae elder generation heating water reflux, extract, 2-4 time, 0.5-2.5 hour at every turn, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0 ~ 1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Step B: preparation intermediate II

B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II;

Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, Recycled ethanol is concentrated into relative density 1-1.0 ~ 1.4, and centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrated, namely get intermediate II; Or after the drying the powder of intermediate II;

Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, make into suspension, left standstill 12-48 hour, and filtered, filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, gets respectively the extract of Pulvis Cornus Bubali Concentratus powder, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder,, add respectively the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filter, filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leave standstill, get supernatant, Recycled ethanol, be concentrated into relative density 1-1.0 ~ 1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrate, get respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Step C: preparation intermediate III

C1: get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 3-5% sodium hydroxide 4-8 times of weight, left standstill 12-48 hour, filter, filtrate transfers pH value to 3-5, and is concentrated, adds 30-80% ethanol 8-15 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get intermediate III; Or after the drying the powder of intermediate III;

Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 3-5% sodium hydroxide 4-8 times of weight, left standstill 12-48 hour, filter, filtrate transfers pH value to 3-5, and is concentrated, adds 30-80% ethanol 8-15 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, adding 4-8 times of weight 5-10% hydrochloric acid left standstill 8-24 hour, filtered, and filtrate transfers pH value to 3-5, and is concentrated, and adding is washed to colourless, namely gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, get intermediate III or the powder of intermediate III;

Step D: preparation medicated powder

D1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, be mixed to get medicated powder;

Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder;

Step e: crude drug intermediate

The powder of intermediate compound I, II, III or intermediate compound I, II, III is mixed with medicated powder, get the crude drug intermediate.

Wherein steps A is preferably as follows method:

A1: with the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 3 times, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get the supernatant Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A2: with the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 3 times, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A3: with Radix Curcumae elder generation heating water reflux, extract, 3 times, each 1.5 hours, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get the supernatant Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A4: with Radix Curcumae elder generation heating water reflux, extract, 3 times, each 1.5 hours, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I.

Wherein step B is preferably as follows method:

B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II;

Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, and Recycled ethanol, concentrated, namely get intermediate II; Or after the drying the powder of intermediate II;

Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively 6% dilute hydrochloric acid, consumption is 10 times of weight, make into suspension, left standstill 24 hours, and filtered, filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, gets respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively 6% dilute hydrochloric acid, consumption is 10 times of weight, make into suspension, left standstill 24 hours, and filtered, filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leave standstill, get supernatant, Recycled ethanol, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrate, get respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.

Wherein step C is preferably as follows method:

C1: get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, adds 50% ethanol, 12 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get intermediate III; Or after the drying the powder of intermediate III;

Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, adds 50% ethanol, 12 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, and adding is washed to colourless, namely gets Realgar extract, or get the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, get intermediate III or the powder of intermediate III.

Wherein step D is preferably as follows method:

Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder.

Wherein, above-mentioned any step all can be substituted by conventional method.

Wherein, above-mentioned macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.

Technique 2: formed by following steps A, B, C and D

Steps A: preparation intermediate compound I

Step B: preparation intermediate II

B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add the 30-80% ethanol of 4-10 times of weight, 40-60 ℃ warm macerating 12-48 hour, filter, get filtrate, Recycled ethanol, concentrated, namely get intermediate II; Or after the drying the powder of intermediate II;

Step C: preparation medicated powder

C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, be mixed to get medicated powder;

Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder;

Step D: crude drug intermediate

The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder, get the crude drug intermediate.

Wherein steps A is preferably as follows method:

Wherein step B is preferably as follows method:

B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrate, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II.

Wherein step C is preferably as follows method:

C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or be mixed to get medicated powder;

Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder.

By pharmacodynamic experiment, show that medicinal composition spray of the present invention or aerosol have analgesic, antiinflammatory, antithrombotic forms and the effect of blood pressure lowering.

Following experimental example and embodiment are used for further specifying but are not limited to the present invention.

The medicinal composition spray of the present invention that experimental example 1 embodiment of the invention 1-30 makes or aerosol are on the hypertensive impact of rat experiment

Laboratory animal: healthy male Waster rat, body weight 190g～210g;

Experiment equipment: RBP-1 type rat blood pressure meter;

Experimental drug and reagent: modeling agent: androlin; Get medicinal composition spray of the present invention or aerosol that embodiment of the invention 1-30 makes, pulverize, be mixed with 100mg/ml with normal saline, 4-5 ℃ of preservation.

Experimental technique: get healthy rat, be divided at random 28 groups, 8 every group, survey normotensive value and continuous measurement 3 days.After the METHOD FOR CONTINUOUS DETERMINATION 3 days, subcutaneous injection androlin 25mg/kg/ day, each group gavages respectively equivalent (1g/kg) medicinal composition spray of the present invention or aerosol, continuous 10 days.Measure animal blood pressure on time, observe its blood pressure, the results are shown in Table 1.

Table 1 medicinal composition spray of the present invention or aerosol are on the hypertensive impact of rat test (n=8, mmHg, X ± S)

Table 1 shows that medicinal composition spray or aerosol that embodiment of the invention 1-30 prepares all have significant blood pressure reduction effect.

The medicinal composition spray that experimental example 2 embodiment of the invention 1-30 prepare or aerosol are to the analgesic and antiinflammatory action of inflammatory rat

Laboratory animal: healthy male Waster rat, body weight 190g～210g;

Experiment equipment: pointer electron temperature indicator.

Pyrogen: 1% carrageenin.

Experimental technique: take by weighing carrageenin 100mg, add sterile saline 10ml, mixing, in 4 ℃ of refrigerators, take out morning next day, is inverted to make suspension even for several times, for subsequent use; Get medicinal composition spray or aerosol that embodiment of the invention 1-30 prepares, be mixed with 100mg/ml with normal saline respectively, 4 ℃ save backup; Healthy rat every day is surveyed axil temperature 2 times (upper and lower noon each 1 time) with the electronics temperature indicator, continuous 3 days, chooses the body temperature rat that is no more than 0.3 ℃ of fluctuating and is divided at random 28 groups, 10 every group.Every group gavages medicinal composition spray of the present invention or aerosol 1g/kg, and after this administration measures its axil temperature simultaneously in rat rear foot ripple plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ pawl on time, the results are shown in Table 2.

The impact of rat fever due to table 2 medicinal composition spray of the present invention or the aerosol on Carrageenan (℃, X ± S)

Table 2 shows that medicinal composition spray or aerosol that embodiment of the invention 1-30 prepares all have effect significant analgesic and antiinflammatory.

Following embodiment all can realize the described effect of above-mentioned experimental example.

The specific embodiment

Crude drug described in the following embodiment forms 1 and is:

Artificial Calculus Bovis 1kg Pulvis Fellis Suis 13kg Rhizoma Coptidis 10kg

Radix Scutellariae 10kg Margarita 3kg Fructus Gardeniae 10kg

Radix Curcumae 10kg Haematitum 4kg Realgar 6kg

Cinnabaris 4kg Mentholum 1kg Gypsum Fibrosum 8kg

Borneolum Syntheticum 2kg Pulvis Cornus Bubali Concentratus 13kg Concha Margaritifera 5kg.

Described crude drug forms 2 and is:

Artificial Calculus Bovis 0.7kg Pulvis Fellis Suis 18kg Rhizoma Coptidis 6kg

Radix Scutellariae 14kg Margarita 2kg Fructus Gardeniae 14kg

Radix Curcumae 6kg Haematitum 5kg Realgar 4kg

Cinnabaris 5kg Mentholum 0.7kg Gypsum Fibrosum 11kg

Borneolum Syntheticum 1kg Pulvis Cornus Bubali Concentratus 18kg Concha Margaritifera 3kg.

Described crude drug forms 3 and is:

Artificial Calculus Bovis 1.8kg Pulvis Fellis Suis 9kg Rhizoma Coptidis 14kg

Radix Scutellariae 6kg Margarita 4kg Fructus Gardeniae 6kg

Radix Curcumae 14kg Haematitum 3kg Realgar 8kg

Cinnabaris 3kg Mentholum 1.8kg Gypsum Fibrosum 6kg

Borneolum Syntheticum 3.5kg Pulvis Cornus Bubali Concentratus 9kg Concha Margaritifera 7kg.

Described process 1 A1 is:

A1: with the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 3 times, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get the supernatant Recycled ethanol, concentrate, get the powder of intermediate compound I after the drying.

Described process 1 A2 is:

With the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 3 times, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I.

Described process 1 A3 is:

With Radix Curcumae elder generation heating water reflux, extract, 3 times, each 1.5 hours, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get the supernatant Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I.

Described process 1 A4 is:

With Radix Curcumae elder generation heating water reflux, extract, 3 times, each 1.5 hours, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I.

Described process 1 B1 is:

Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II.

Described process 1 B2 is:

Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, and Recycled ethanol, concentrated, namely get intermediate II; Or after the drying the powder of intermediate II.

Described process 1B3 is:

Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, gets respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.

Described process 1 B4 is:

Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leave standstill, get supernatant, Recycled ethanol, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrate, get respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.

Described process 1 C1 is:

Get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, adds 50% ethanol, 12 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get intermediate III; Or after the drying the powder of intermediate III.

Described process 1 C2 is:

Get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, adds 50% ethanol, 12 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, and adding is washed to colourless, namely gets Realgar extract, or get the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, get intermediate III or the powder of intermediate III.

Described process 1 D1 is:

Respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, be mixed to get medicated powder.

Described process 1 D2 is:

Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder.

Described process 2 A1 are:

With the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 3 times, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get the supernatant Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I.

Described process 2 A2 are:

Described process 2 A3 are:

Described process 2 A4 are:

Described process 2 B1 are:

Crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrate, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II.

Described process 2 C1 are:

Respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or be mixed to get medicated powder.

Described process 2 C2 are:

Embodiment 1: spray of the present invention

Crude drug forms 1;

Solubilizing agent: Laurel Pyrusussuriensis gallbladder 120kg

Diluent: glycerol 800L

Cosolvent: tween 80 150kg

Correctives: orange syrup 30kg

Antiseptic: Nipagin ester 30kg

Stabilizing agent: ethylenediaminetetraacetic acid 30kg

Antioxidant: vitamin C 30kg;

Get the above-mentioned raw materials medicine, make intermediate through conventional technique, add above-mentioned adjuvant and make spray.

Embodiment 2: spray of the present invention

Crude drug forms 2;

Solubilizing agent: Sorbitan Palmitate 30kg sorbitan stearate 50kg

Diluent: ethanol 500L glycerol 500L

Cosolvent: tween 80 200kg;

The preparation method of intermediate is steps A 3, B2, C1, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 3: spray of the present invention

Crude drug forms 3;

Solubilizing agent: sorbitan stearate 60kg polysorbate 20 60kg

Diluent: ethanol 400L glycerol 200L propylene glycol 200L

Cosolvent: hexadecanol 100kg octadecanol 50kg

Correctives: Cortex cinnamomi japonici (Ramulus Cinnamomi) syrup 30kg

Stabilizing agent: ethylenediaminetetraacetic acid 20kg disodiumedetate 10kg

Antioxidant: sodium sulfite 10kg Cys2 0kg;

The preparation method of intermediate is steps A 4, B2, C1, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 4: spray of the present invention

Crude drug forms 1;

Solubilizing agent: Sorbitan Tristearate 100kg cetyltrimethylammonium base amine bromide 50kg

Diluent: glycerol 200L Macrogol 200 L

Cosolvent: tween 80 100kg

Correctives: cyclamate 30kg xylitol 15kg

Stabilizing agent: sodium ethylene diamine tetracetate calcium 15kg

Antioxidant: paddy cystine 30kg ascorbic acid 15kg;

The preparation method of intermediate is steps A 3, B3, C1, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 5: spray of the present invention

Crude drug forms 2;

Solubilizing agent: Ai Moerfu 60kg PLURONICS F87 60kg

Diluent: water 400L propylene glycol 400L

Cosolvent: Tween-60 150kg;

Embodiment 6: spray of the present invention

Crude drug forms 3;

Solubilizing agent: Sorbitan Oleate 150kg

Diluent: glycerol 100L propylene glycol 100L Macrogol 200 L

Cosolvent: tween 80 100kg

Correctives: xylitol 15kg

Stabilizing agent: glycerol, Polyethylene Glycol, dextran, ethylenediaminetetraacetic acid, disodiumedetate and sodium ethylene diamine tetracetate Ca45 kg

Antioxidant: sodium sulfite 15kg;

The preparation method of intermediate is steps A 4, B3, C1, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 7: spray of the present invention

Crude drug forms 1;

Solubilizing agent: polysorbate 60 20kg stearate 60kg cetomacrogol 40kg

Diluent: propylene glycol 400L PEG400 L

Cosolvent: octadecanol 50kg lecithin 100kg

Correctives: cyclohexyl sulfamic acid 15kg

Antiseptic: benzyl alcohol 30kg chlorobutanol 15kg

Stabilizing agent: dextran 1 5kg ethylenediaminetetraacetic acid 30kg;

The preparation method of intermediate is steps A 1, B1, C1, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 8: spray of the present invention

Crude drug forms 2;

Solubilizing agent: Sorbitan Tristearate 50kg polysorbate 65 100kg

Diluent: ethanol 200L glycerol 200L

Cosolvent: tween 80 100kg

Correctives: apple essence 10kg flavoring banana essence 20kg

Antiseptic: benzyl alcohol 10kg phenylmercuric nitrate 10kg phenoxyethanol 10kg

Stabilizing agent: Polyethylene Glycol 30kg;

The preparation method of intermediate is steps A 3, B1, C1, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 9: spray of the present invention

Crude drug forms 3;

Solubilizing agent: polysorbate 40 40kg polyoxyethylene 40 40kg

Diluent: propylene glycol 500L glycerol 500L

Cosolvent: tween 80 200kg;

The preparation method of intermediate is steps A 2, B2, C2, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 10: spray of the present invention

Crude drug forms 1;

Solubilizing agent: PLURONICS F87 60kg sodium lauryl sulphate 60kg

Diluent: ethanol 300L glycerol 300L propylene glycol 200L

Cosolvent: tween 80 100kg hexadecanol 50kg;

The preparation method of intermediate is steps A 3, B2, C2, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 11: spray of the present invention

Crude drug forms 2;

Solubilizing agent: sorbitan stearate 50kg polysorbate 85 100kg

Diluent: glycerol 200L Polyethylene Glycol 100L glycerol 100L

Cosolvent: hexadecanol 100kg

Correctives: vinegar sultone potassium 15kg

Antiseptic: methyl parahydroxybenzoate 30kg benzyl alcohol 15kg

Antioxidant: cysteine 15kg;

The preparation method of intermediate is steps A 1, B3, C1, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 12: spray of the present invention

Crude drug forms 3;

Solubilizing agent: paregal O 60kg peregal A 60kg

Diluent: water 400L propylene glycol 400L

Cosolvent: tween 80 50kg hexadecanol 100kg

Correctives: sucralose 10kg Fructus Citri Limoniae 10kg Herba Menthae Haplocalycis volatile oil 10kg

Antiseptic: methyl parahydroxybenzoate 30kg

Antioxidant: sodium sulfite 15kg cysteine 15kg;

Embodiment 13: spray of the present invention

Crude drug forms 1;

Solubilizing agent: Laurel Pyrusussuriensis gallbladder 60kg Sorbitan Palmitate 40kg sorbitan stearate 20kg

Diluent: propylene glycol 200L Macrogol 200 L glycerol 400L

Cosolvent: hexadecanol 50kg lecithin 100kg

Correctives: contracting phenodiazine acidic group amide 15kg agedoite-vinegar sultone salt 15kg cyclohexyl sulfamic acid 15kg

Antioxidant: cysteine 15kg paddy cystine 15kg ascorbic acid 15kg;

The preparation method of intermediate is steps A 4, B3, C1, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 14: spray of the present invention

Crude drug forms 3;

Solubilizing agent: stearate 50kg paregal O 50kg PLURONICS F87 50kg

Diluent: water 100L ethanol 100L glycerol 100L propylene glycol 100L

Cosolvent: tween 80 50kg hexadecanol 50kg

Stabilizing agent: ethylenediaminetetraacetic acid 30kg disodiumedetate 15kg

Antioxidant: sodium sulfite 15kg;

The preparation method of intermediate is steps A 2, B4, C2, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 15: spray of the present invention

Crude drug forms 3;

Solubilizing agent: sorbitan stearate 80kg

Diluent: ethanol 600L glycerol 400L

Cosolvent: octadecanol 100kg lecithin 100kg

Correctives: Cortex cinnamomi japonici (Ramulus Cinnamomi) syrup 25kg sorbitol 20kg

Antiseptic: phenoxyethanol 15kg

Stabilizing agent: sodium ethylene diamine tetracetate calcium 15kg

Antioxidant: vitamin C 30kg sodium sulfite 15kg;

The preparation method of intermediate is steps A 4, B4, C2, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes spray of the present invention.

Embodiment 16: aerosol of the present invention

Crude drug forms 1;

Solubilizing agent: Sorbitan Tristearate 80kg polysorbate 20 40kg

Diluent: PEG400 L glycerol 400L

Cosolvent: tween 80 50kg hexadecanol 100kg

Propellant: isceon 200kg

Correctives: agedoite 10kg agedoite-vinegar sultone salt 10kg cyclohexyl sulfamic acid 10kg

Antiseptic: this pure 10kg of benzyl alcohol 10kg Nipagin ester 10kg benzene second

Stabilizing agent: Dextran 10 kg ethylenediaminetetraacetic acid 10kg disodiumedetate 10kg

Antioxidant: sodium sulfite 10kg sodium sulfite 10kg cysteine 10kg;

The preparation method of intermediate is steps A 1, B1, C2, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 17: aerosol of the present invention

Crude drug forms 3;

Solubilizing agent: Ai Moerfu 70kg sodium lauryl sulphate 80kg

Diluent: propylene glycol 300L Polyethylene Glycol 100L

Cosolvent: Tween-60 50kg lecithin 50kg

Propellant: dichlorotetra-fluoroethane 100kg propane 100kg;

The preparation method of intermediate is steps A 2, B1, C2, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 18: aerosol of the present invention

Crude drug forms 3;

Solubilizing agent: sorbitan stearate 80kg

Diluent: glycerol 200L propylene glycol 200L PEG400 L glycerol 600L

Cosolvent: Tween-60 100kg lecithin 100kg

Propellant: dichlorodifluoromethane 100kg iso-butane 100kg

Correctives: Fructus Citri Limoniae 20kg agedoite 10kg

Antiseptic: sorbic acid 10kg benzyl alcohol 20kg

Antioxidant: sodium sulfite 20kg sodium sulfite 10kg;

The preparation method of intermediate is steps A 3, B4, C2, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 19: aerosol of the present invention

Crude drug forms 1;

Solubilizing agent: Sorbitan Oleate 50kg polyoxyethylene sorbitan monoleate 50kg PLURONICS F87 50kg

Diluent: water 400L

Cosolvent: tween 80 100kg

Propellant: tetrafluoroethane 100kg

Correctives: fructose 15kg;

The preparation method of intermediate is steps A 4, B3, C2, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 20: aerosol of the present invention

Crude drug forms 2;

Solubilizing agent: peregal A 60kg poloxamer 237 60kg

Diluent: propylene glycol 400L glycerol 400L

Cosolvent: hexadecanol 50kg lecithin 100kg

Propellant: isceon 50kg normal butane 50kg

Antioxidant: paddy cystine 20kg ascorbic acid 10kg;

The preparation method of intermediate is steps A 1, B4, C1, the D2 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 21: aerosol of the present invention

Crude drug forms 3;

Solubilizing agent: Sorbitan Oleate 50kg sorbitan stearate 50kg sodium lauryl sulphate 50kg

Diluent: glycerol 200L propylene glycol 200L

Cosolvent: octadecanol 100kg

Propellant: heptafluoro-propane 100kg propane 100kg

Correctives: contracting phenodiazine acidic group amide 30kg agedoite-vinegar sultone salt 15kg

Stabilizing agent: disodiumedetate 15kg

Antioxidant: vitamin C 20kg Cys2 5kg;

The preparation method of intermediate is steps A 1, B4, C2, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 22: aerosol of the present invention

Crude drug forms 1;

Solubilizing agent: Laurel Pyrusussuriensis gallbladder 40kg Sorbitan Palmitate 40kg

Diluent: glycerol 400L propylene glycol 600L

Cosolvent: tween 80 100kg hexadecanol 100kg

Propellant: dichlorodifluoromethane 50kg dichlorotetra-fluoroethane 50kg;

The preparation method of intermediate is steps A 1, B1, the C1 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 23: aerosol of the present invention

Crude drug forms 2;

Solubilizing agent: Sorbitan Tristearate 100kg Sorbitan Trioleate 50kg

Diluent: PEG400 L

Cosolvent: hexadecanol 50kg lecithin 50kg

Propellant: isceon 100kg tetrafluoroethane 100kg heptafluoro-propane 100kg;

The preparation method of intermediate is steps A 2, B1, the C1 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 24: aerosol of the present invention

Crude drug forms 3;

Solubilizing agent: polysorbate 20 50kg polyoxyethylene 4030kg stearate 40kg

Diluent: propylene glycol 400L glycerol 400L

Cosolvent: octadecanol 50kg lecithin 100kg

Propellant: heptafluoro-propane 200kg iso-butane 100kg

Correctives: aspartame 15kg contracting phenodiazine acidic group amide 30kg

Antiseptic: this pure 15kg of benzene second

Stabilizing agent: sodium ethylene diamine tetracetate calcium 15kg;

The preparation method of intermediate is steps A 3, B1, the C1 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 25: aerosol of the present invention

Crude drug forms 1;

Solubilizing agent: Sorbitan Tristearate 60kg polysorbate 65 50kg paregal O 40kg

Diluent: water 200L ethanol 200L

Cosolvent: Tween-60 50kg tween 80 50kg

Propellant: dichlorotetra-fluoroethane 60kg tetrafluoroethane 40kg;

The preparation method of intermediate is steps A 4, B1, the C1 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 26: aerosol of the present invention

Crude drug forms 2;

Solubilizing agent: Laurel Pyrusussuriensis gallbladder 40kg Sorbitan Palmitate 80kg

Diluent: ethanol 600L glycerol 200L

Cosolvent: tween 80 40kg hexadecanol 50kg octadecanol 60kg

Propellant: dichlorotetra-fluoroethane 150kg propane 150kg;

The preparation method of intermediate is steps A 1, B1, the C2 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 27: aerosol of the present invention

Crude drug forms 3;

Solubilizing agent: Sorbitan Oleate 80kg

Diluent: glycerol 500L propylene glycol 500L

Cosolvent: tween 80 80kg hexadecanol 60kg lecithin 60kg

Propellant: iso-butane 100kg normal butane 100kg

Correctives: cyclamate 15kg xylitol 15kg

Antioxidant: vitamin C 15kg sodium sulfite 30kg;

The preparation method of intermediate is steps A 2, B1, the C2 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 28: aerosol of the present invention

Crude drug forms 1;

Solubilizing agent: stearate 40kg paregal O 40kg

Diluent: water 500L ethanol 300L glycerol 200L

Cosolvent: Tween-60 100kg hexadecanol 100kg

Propellant: dichlorotetra-fluoroethane 150kg tetrafluoroethane 150kg

Stabilizing agent: ethylenediaminetetraacetic acid 20kg disodiumedetate 10kg;

The preparation method of intermediate is steps A 3, B1, the C2 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 29: aerosol of the present invention

Crude drug forms 2;

Solubilizing agent: sorbitan stearate 50kg Sorbitan Oleate 70kg

Diluent: glycerol 300L propylene glycol 500L

Cosolvent: hexadecanol 50kg octadecanol 70kg lecithin 30kg

Propellant: iso-butane 200kg normal butane 100kg

Correctives: sucralose 30kg flavoring banana essence 15kg

Antiseptic: benzyl alcohol 15kg

Stabilizing agent: disodiumedetate 15kg

Antioxidant: sodium sulfite 20kg ascorbic acid 25kg;

The preparation method of intermediate is steps A 4, B1, the C2 in the technique 2, and the powder of intermediate compound I, II is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Embodiment 30: aerosol of the present invention

Crude drug forms 3;

Solubilizing agent: polysorbate 20 50kg polyoxyethylene 40 30kg

Diluent: ethanol 400L glycerol 200L propylene glycol 400L

Cosolvent: lecithin 200kg

Propellant: propane 50kg normal butane 50kg

Correctives: sorbitol 20kg sucralose 10kg;

The preparation method of intermediate is steps A 3, B3, C1, the D1 in the technique 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, gets the crude drug intermediate, adds above-mentioned adjuvant and makes aerosol of the present invention.

Claims

1. the preparation method of a medicinal composition spray or aerosol is characterized in that the method is any one in the following method:

Technique 1: formed by following steps A, B, C, D and E

Steps A: preparation intermediate compound I

Or A2: with the common heating water reflux, extract, of crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrated, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Or A4: with Radix Curcumae elder generation heating water reflux, extract, 2-4 time, 0.5-2.5 hour at every turn, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Step B: preparation intermediate II

B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II;

Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, Recycled ethanol is concentrated into relative density 1-1.0～1.4, and centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrated, namely get intermediate II; Or after the drying the powder of intermediate II;

Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, make into suspension, left standstill 12-48 hour, and filtered, filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, gets respectively the extract of Pulvis Cornus Bubali Concentratus powder, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, make into suspension, left standstill 12-48 hour, and filtered, filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leave standstill, get supernatant, Recycled ethanol, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, Recycled ethanol, concentrate, get respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Step C: preparation intermediate III

Step D: preparation medicated powder

Step e: crude drug intermediate

The powder of intermediate compound I, II, III or intermediate compound I, II, III is mixed with medicated powder, get the crude drug intermediate;

Technique 2: formed by following steps A, B, C and D

Steps A: preparation intermediate compound I

Step B: preparation intermediate II

Step C: preparation medicated powder

Step D: crude drug intermediate

The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder, get the crude drug intermediate;

Above-mentioned raw materials medicine intermediate is added adjuvant according to common process make spray or aerosol;

Wherein, above-mentioned macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9;

The raw material of this medicinal composition spray or aerosol consists of:

The adjuvant of spray forms:

Solubilizing agent 50-180 weight portion

Diluent 350-1200 parts by volume

Cosolvent 80-220 weight portion;

The adjuvant of aerosol consists of and add following adjuvant again on the basis of above-mentioned spray adjuvant:

Propellant 50-350 weight portion.

2. the preparation method of spray as claimed in claim 1 or aerosol is characterized in that the method is any one in the following method:

Technique 1: formed by following steps A, B, C, D and E

Steps A: preparation intermediate compound I

Or A4: with Radix Curcumae elder generation heating water reflux, extract, 3 times, each 1.5 hours, volatile oil was for subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrated, spray into volatile oil, namely get intermediate compound I; Or after the drying the powder of intermediate compound I;

Step B: preparation intermediate II

B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II;

Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, and Recycled ethanol, concentrated, namely get intermediate II; Or after the drying the powder of intermediate II;

Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, and Recycled ethanol is concentrated, gets respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add respectively 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide or other alkali liquor; Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leave standstill, get supernatant, Recycled ethanol, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, Recycled ethanol, concentrate, get respectively the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera, namely get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;

Step C: preparation intermediate III

Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, adds 50% ethanol, 12 times of weight; Get supernatant, Recycled ethanol, concentrated, namely get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrate is transferred pH value to 4, and is concentrated, and adding is washed to colourless, namely gets Realgar extract, or get the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, get intermediate III or the powder of intermediate III;

Step D: preparation medicated powder

Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder;

Step e: crude drug intermediate

Technique 2: formed by following steps A, B, C and D

Steps A: preparation intermediate compound I

Step B: preparation intermediate II

B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrate, and Recycled ethanol is concentrated, namely gets intermediate II; Or after the drying the powder of intermediate II;

Step C: preparation medicated powder

Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation namely gets the Cinnabaris impalpable powder; The impalpable powder of above-mentioned four kinds of crude drug is mixed to get medicated powder;

Step D: crude drug intermediate

3. the preparation method of spray as claimed in claim 1 or 2 or aerosol is characterized in that the method Raw medicine consists of:

4. such as the preparation method of the arbitrary described spray of claim 1-2 or aerosol, it is characterized in that adjuvant consists of in the method:

The adjuvant of spray forms:

Propellant 200 weight portions

Or propellant 100 weight portions

Or propellant 300 weight portions.

5. the preparation method of a medicinal composition spray or aerosol is characterized in that the method is any one in the following method:

Technique 1: formed by following steps A, B, C, D and E

Steps A: preparation intermediate compound I

Step B: preparation intermediate II

Step C: preparation intermediate III

Step D: preparation medicated powder

Step e: crude drug intermediate

Technique 2: formed by following steps A, B, C and D

Steps A: preparation intermediate compound I

Step B: preparation intermediate II

Step C: preparation medicated powder

Step D: crude drug intermediate

The raw material of this medicinal composition spray or aerosol consists of:

The adjuvant of spray forms:

Solubilizing agent 50-180 weight portion

Diluent 350-1200 parts by volume

Cosolvent 80-220 weight portion;

Propellant 50-350 weight portion;

On the adjuvant basis of described spray and aerosol, add again:

6. the preparation method of spray as claimed in claim 5 or aerosol, it is characterized in that the adjuvant that adds in this spray wherein or the aerosol consist of following any one:

7. such as the preparation method of claim 1,2 arbitrary described sprays or aerosol, it is characterized in that in the method:

Solubilizing agent is Laurel Pyrusussuriensis gallbladder, Sorbitan Palmitate, sorbitan stearate, Sorbitan Tristearate, Sorbitan Oleate, sorbitan stearate, Sorbitan Tristearate, Sorbitan Oleate, Sorbitan Trioleate, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polyoxyethylene sorbitan monoleate, polysorbate 85, Myrj 52, paregal O, peregal A, Ai Moerfu, cetomacrogol, PLURONICS F87, poloxamer 237, in sodium lauryl sulphate and the cetyltrimethylammonium base amine bromide one or more;

Diluent is one or more in water, Diluted Alcohol, glycerol, propylene glycol, Polyethylene Glycol and the glycerol;

Cosolvent is one or more in Tween-60, tween 80, hexadecanol, octadecanol and the lecithin;

Propellant is one or more in isceon, dichlorodifluoromethane, dichlorotetra-fluoroethane, tetrafluoroethane, heptafluoro-propane, propane, iso-butane and the normal butane.

8. such as the preparation method of claim 5,6 arbitrary described sprays or aerosol, it is characterized in that in the method:

Correctives is one or more in orange syrup, Cortex cinnamomi japonici (Ramulus Cinnamomi) syrup, glycerol, sorbitol, mannitol, Folium Stevlae Rebaudianae, red bright alcohol, glucide, cyclamate, xylitol, aspartame, fructose, sucralose, Fructus Citri Limoniae, Herba Menthae Haplocalycis volatile oil, apple essence, flavoring banana essence, vinegar sultone potassium, contracting phenodiazine acidic group amide, agedoite, agedoite-vinegar sultone salt and the cyclohexyl sulfamic acid;

Stabilizing agent is one or more in glycerol, Polyethylene Glycol, dextran, ethylenediaminetetraacetic acid, disodiumedetate and the sodium ethylene diamine tetracetate calcium;

Antiseptic is one or more in sorbic acid, ethanol, benzyl alcohol, Nipagin ester, this alcohol of benzene second, benzalkonium chloride, methyl parahydroxybenzoate, benzyl alcohol, chlorobutanol, thimerosal, phenylmercuric nitrate, hibitane and the phenoxyethanol;

Antioxidant is one or more in vitamin C, sodium sulfite, sodium sulfite, cysteine, paddy cystine and the ascorbic acid.

9. the preparation method of spray as claimed in claim 3 or aerosol is characterized in that in the method:

10. the preparation method of spray as claimed in claim 4 or aerosol is characterized in that in the method:

11. the preparation method of spray as claimed in claim 5 or aerosol is characterized in that in the method:

Stabilizing agent is among a kind of or several in glycerol, Polyethylene Glycol, dextran, ethylenediaminetetraacetic acid, disodiumedetate and the sodium ethylene diamine tetracetate calcium;

Antioxidant is among a kind of or several in vitamin C, sodium sulfite, sodium sulfite, cysteine, paddy cystine and the ascorbic acid;