CN101670020A - Composition for treating premenstrual syndrome - Google Patents
Composition for treating premenstrual syndrome Download PDFInfo
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- CN101670020A CN101670020A CN200910085572A CN200910085572A CN101670020A CN 101670020 A CN101670020 A CN 101670020A CN 200910085572 A CN200910085572 A CN 200910085572A CN 200910085572 A CN200910085572 A CN 200910085572A CN 101670020 A CN101670020 A CN 101670020A
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- chaste tree
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Abstract
The invention provides a composition for treating premenstrual syndrome, which comprises natural medicine vitex extract and vitamin B6. Furthermore, the invention provides an extraction method of thenatural medicine and a method for preparing the final composition.
Description
Technical field
The present invention relates to the prevention and the treatment of premenstrual syndrome, the compound of a kind of natural drug and vitamin is provided, and the preparation method of natural drug and final composition is provided.
Background technology
Premenstrual syndrome (pemenstrual syndrome PMS) is one group of symptom of neuroendocrine disturbance.With anxiety, irritability, emotional instability, depression or migraine headache, lower limbs edema, abdominal distention, stomachache and mastalgia is feature, and these diseases can influence women's physical and mental health and operate as normal.Data shows according to statistics, about 30-60﹠amp; The women have premenstrual syndrome and menstrual period syndrome puzzlement, have nearly 64% women oneself to buy OTC agents alleviate pain.PMS pathogeny and symptom complexity still lack especially effectively treatment means and measure at present.The Western medicine of current treatment premenstrual syndrome mostly is analgesic such as acetaminophen, ibuprofen etc. and diuretic such as caffeine, ammonium chloride and pamabrom etc., side effect such as the issuable gastrointestinal upset of Western medicine are conspicuous, but the advantage of symptomatic treatment instant effect is also arranged; Part Chinese medicine such as Radix Angelicae Sinensis, Herba Leonuri mainly are the effects of playing regulating menstruation by the QI invigorating that nourishes blood, and these medical materials yet there are no its pharmacological research that more deep treatment premenstrual syndrome is arranged.
The Vitex agnus-castus Linn. fruit be used for the treatment of women obstetrics and gynaecopathia in Europe among the people being widely used; chemical constituent and pharmacological research are shown; dopamine active substance in the extract mainly is that two obedient constituents are main chemical compositions of treatment premenstrual syndrome; the Vitex plant of China is widely distributed; medical material is abundant, and also contains the two obedient class chemical constituents that are not less than Vitex agnus-castus Linn. in report Herba Viticis Cannabifoliae or the Vitex rotundifolia fruit.Domestic exploitation to Herba Viticis Cannabifoliae only limits to the extract Oleum Viticis Negundo of Folium Viticis Negundo, and the listing product is a Viticis Negundo Oil Emulsion, and indication is cough with asthma, chronic bronchitis, and does not see the research and development that specialty is arranged for the effect of Herba Viticis Cannabifoliae fruit extract treatment premenstrual syndrome.
In China, it is considered as administering the good medicine of symptoms such as eczema, asthma, deafness, anticancer and women leucorrhea on the medical book always.The agents area of Herba Viticis Cannabifoliae is a Folium Viticis Negundo in the Chinese Pharmacopoeia, and extract is an Oleum Viticis Negundo, and the listing preparation is a viticis negundo oil capsules, and indication is cough with asthma and chronic bronchitis; Domestic have the Fructus Viticis Cannabifoliae health tea to go on the market; Do not see the medicinal Herba Viticis Cannabifoliae fruit extract preparation that research or listing are arranged, do not see the domestic drug efficacy study that has the Herba Viticis Cannabifoliae extract to be used for the premenstrual syndrome treatment yet.
Vitamin B6 has the effect of alleviating premenstrual syndrome as natural diuretic.Because the shortage of vitamin B6 can cause or increase the weight of the PMS symptom, alleviate premenstrual syndrome for vitamin B6 so clinical general meeting is oral.
The present invention herds the compositions that chaste tree extract and vitamin B6 are formed compound recipe with natural drug, a kind of treatment is provided and has alleviated the effective way of premenstrual syndrome.
Summary of the invention
The purpose of this invention is to provide the compositions of a kind of treatment and prevention premenstrual syndrome, and the preparation method of natural drug wherein is provided, and the final process for preparing medicine of compositions.
The consisting of of a kind of compositions for the treatment of the syndrome in menstrual period among the present invention: herd extract, the vitamin B6 of chaste tree platymiscium raw material, comprise that also some conventional pharmaceutical necessitieses are as excipient.
Wherein the unit dose of vitamin B6 is 20-40mg.
The extract of extract is the 1/6-12 of crude drug.
Herding the ratio of chaste tree glycosides in extractum is 0.1%-0.6%.
The final form of medication of compositions of the present invention is tablet, capsule, granule.
Described excipient comprises pharmaceutically acceptable diluent, binding agent, disintegrating agent and fluidizer lubricant.
Describedly herd chaste tree and belong to natural plants and comprise: Vitex rotundifolia, herd chaste tree, Honoka and herd chaste tree, pale reddish brownly herd chaste tree.
The content's index of raw extract is pale reddish brownly to herd chaste tree and Honoka is herded the chaste tree glycosides.
Described raw material comprises a kind of in the aerial parts of the fruit of herding the chaste tree platymiscium, herb, herb or other positions.
The preparation process of raw extract is as follows: 1. prepare extracting solution: take by weighing the medicinal material drying coarse powder of herding the chaste tree plant, with extracting solvent extraction one to repeatedly, get extracting solution; 2. exquisite concentrate drying: said extracted liquid is concentrated, get concentrated solution.Concentrated solution is concentrated into crushed after being dried, promptly gets the powder of extract of the present invention.
Wherein the extraction solvent of step described in 1. is meant ethanol or the methanol of 30-95%.Method for concentration described in the 2. exquisite concentrate drying of step is meant decompression and solvent recovery.
The specific embodiment
Below come the present invention is done simple explanation by specific embodiment, but can't constitute any restriction to the present invention.
Embodiment 1
The preparation of natural drug extract: will herd the chaste tree medical material and clean, and soak 6-24 hour interior the decoction 2-6 hour of rearmounted extraction vessel, each time that decocts is 0.5-3 hour; Extracting solution merges for several times, is condensed into extractum together, and oven dry is pulverized and got final product.
Composition unit's metering (mg)
Extract 50
Vitamin B6 25
Microcrystalline Cellulose 200
Hydroxypropyl methylcellulose 15
65% ethanol is an amount of
Preparation technology: get the extractum among the embodiment 1, after adding microcrystalline Cellulose, vitamin B6, hydroxypropyl methylcellulose mix homogeneously, with adequate amount of ethanol solution-wet system soft material, crossing 18 mesh sieves granulates, granule is crossed 18 mesh sieve granulate after 60 ℃ of dryings, add the magnesium stearate of dried granule gross weight 0.5%, behind the mix homogeneously, tabletting or capsule charge.
Embodiment 2
Composition unit's metering (mg)
Extract 50
Vitamin B6 25
Sucrose 150
Xanthan gum 10
Fructus Citri tangerinae essence 2
Aspartame 2.5
65% ethanol is an amount of
Preparation technology is with embodiment 1.
The acute toxicity test of natural drug:
Experiment purpose: observe and to herd heavy dose of toxic action of giving with little tree after oral in the chaste tree extract 48 hours.
Material: animal subject is the ICR mice, and is male, 18-22g, and grouping, divides two groups, 20 every group by 40 immediately.Freely look for food and drink water room temperature, natural lighting.
Be subjected to the sample particle of reagent thing for embodiment 2.
Test method: irritate stomach, this experiment is divided into two groups of groups with Mus, and 20 every group, be respectively the blank group, give and the isodose triumph of experimental group saline; Irritate the stomach group and give maximum volume (0.8ml/20 only) Cmax (11.5mg/ml) dosage.
Experimental observation: observe the reaction of Mus after the administration immediately, and continuous 15 is sweet, write down body weight at set intervals, added as following table.
Each organizes mice body weight change table
Conclusion (of pressure testing): in the above experiment, observed 48 hours, all do not have animal dead, so LD50 can't determine, show and herd chaste tree extract several avirulences in effective dosage range.
In fact herding the pharmacological effect effect of chaste tree extract finds in secular pharmacological experiment, in order better to adapt to the premenstrual syndrome patient's of the different syndromes and the cause of disease demand, will herd among the present invention chaste tree extract and vitamin B6 with must mixed as the active drug for the treatment of the syndrome in menstrual period.
Claims (10)
1, a kind of compositions for the treatment of premenstrual syndrome is characterized in that compositions is made up of the extract and the vitamin B6 of herding chaste tree platymiscium raw material, comprises that also some conventional pharmaceutical necessitieses are as excipient.
2, the compositions that requires according to claim 1, the unit dose that it is characterized in that vitamin B6 is 20-40mg.
3, compositions according to claim 1, the extract of extract are the 1/6-12 of crude drug.
4, the described compositions of claim 1, the final form of medication that it is characterized by compositions is tablet, capsule, granule.
5, the described compositions of claim 1 is characterized in that the purposes of complex is treatment antagonism premenstrual syndrome.
6, in the compositions that claim 1 requires, its described excipient comprises pharmaceutically acceptable diluent, binding agent, disintegrating agent and fluidizer lubricant.
7, the described compositions of claim 1 is characterized in that describedly herding chaste tree and belonging to natural plants and comprise: Vitex rotundifolia, herd chaste tree, Honoka and herd chaste tree, pale reddish brownly herd chaste tree.
8, compositions according to claim 8, it is characterized by and herding the ratio of chaste tree glycosides in extractum is 0.1%-0.6%.
9, the raw extract that requires according to claim 1, wherein said raw material comprise a kind of in the aerial parts of the fruit of herding the chaste tree platymiscium, herb, herb or other positions.
10. in the compositions according to right 1 requirement, the preparation process of raw extract is as follows: 1. prepare extracting solution: take by weighing the medicinal material drying coarse powder of herding the chaste tree plant, with extracting solvent extraction one to repeatedly, get extracting solution; 2. exquisite concentrate drying: said extracted liquid is concentrated, get concentrated solution.Concentrated solution is concentrated into crushed after being dried, promptly gets the powder of extract of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910085572A CN101670020A (en) | 2009-05-25 | 2009-05-25 | Composition for treating premenstrual syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910085572A CN101670020A (en) | 2009-05-25 | 2009-05-25 | Composition for treating premenstrual syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101670020A true CN101670020A (en) | 2010-03-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910085572A Pending CN101670020A (en) | 2009-05-25 | 2009-05-25 | Composition for treating premenstrual syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101670020A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104418829A (en) * | 2013-09-07 | 2015-03-18 | 山东大学（威海） | Structure, preparation method and use of compound vitrifolin B with anti-tumor effect |
| CN104800679A (en) * | 2015-04-26 | 2015-07-29 | 周玉霞 | Traditional Chinese medicine preparation for treating premenstrual syndrome and preparation method |
-
2009
- 2009-05-25 CN CN200910085572A patent/CN101670020A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104418829A (en) * | 2013-09-07 | 2015-03-18 | 山东大学（威海） | Structure, preparation method and use of compound vitrifolin B with anti-tumor effect |
| CN104800679A (en) * | 2015-04-26 | 2015-07-29 | 周玉霞 | Traditional Chinese medicine preparation for treating premenstrual syndrome and preparation method |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20100317 |