CN105456591A - Manufacturing method of cedar seed preparation for heart nourishing - Google Patents

Manufacturing method of cedar seed preparation for heart nourishing Download PDF

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Publication number
CN105456591A
CN105456591A CN201510981169.4A CN201510981169A CN105456591A CN 105456591 A CN105456591 A CN 105456591A CN 201510981169 A CN201510981169 A CN 201510981169A CN 105456591 A CN105456591 A CN 105456591A
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powder
radix
extract
subsequent use
extractum
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黄文荣
马静
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BAIHUA PHARMACEUTICAL GROUP Co Ltd
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BAIHUA PHARMACEUTICAL GROUP Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/28—Mercury; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/13—Coniferophyta (gymnosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/34—Campanulaceae (Bellflower family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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Abstract

The invention discloses a manufacturing method of a cedar seed preparation for heart nourishing. The cedar seed preparation for heart nourishing is mainly prepared from semen boitae, dangshen, radix astragali preparata, ligusticum wallichii, angelica sinensis, poria cocos, processed radix polygalae, spina date seed, cinnamon, vinegar prepared the fruit of Chinese magnoliavine, herbal leaven of pinellia ternata, honey-fried licorice root and cinnabar. According to the properties of the various drugs in a formula of the cedar seed preparation for heart nourishing and the effects of the drugs in the formula, a specific manufacturing technology and parameters of the cedar seed preparation for heart nourishing are improved, so that an effective component ferulic acid in the preparation is easily detected; the detected ferulic acid has high acid content, so that the preparation is more refined, more remarkable in efficacy and good in clinical curative effect.

Description

A kind of cedar seed nourishes heart the manufacture method of preparation
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of cedar seed and nourish heart the manufacture method of preparation.
Background technology
Chinese medicine extraction is a kind of method conventional in herbal pharmaceutical, and Chemistry for Chinese Traditional Medicine composition is extremely complicated, need extract the effective active ingredient of Chinese herbs of human body from the mixture of complexity.To improve drug effect.
The cedar seed preparation that nourishes heart is made primarily of Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven, Radix Glycyrrhizae Preparata and Cinnabaris; There is QI invigorating, nourish blood, the effect of calming the nerves.For motive deficiency and coldness, palpitation and being susceptible to fright, insomnia and dreamful sleep, forgetful disease such as grade.
In prior art, the cedar seed preparation that nourishes heart makes like this: 12 tastes such as Cinnabaris water flies into impalpable powder, all the other Semen Platycladi are ground into fine powder, with above-mentioned powder facing-up, sieve, mixing, and it is close to add refining, and general ball is dry, to obtain final product.But inventor finds in research process, adopt existing extraction process to make cedar seed and nourish heart in preparation, the effective ingredient in medicine is not easily measured, and especially ferulic acid is not easily measured, and makes the nourish heart clinical efficacy of preparation of cedar seed desirable not enough.
Summary of the invention
The invention provides a kind of cedar seed to nourish heart the manufacture method of preparation.The present invention nourishes heart according to cedar seed the character of each medicine in preparation recipe, and this medicine role in prescription, the nourish heart concrete processing technology of preparation and parameter of cedar seed is improved, the effective ingredient ferulic acid of Radix Angelicae Sinensis and Rhizoma Chuanxiong is easily measured, and the ferulic acid amount measured is high, make the refine more of this medicine, drug effect is more remarkable, and clinical efficacy is good.
To achieve these goals, the invention provides following technical scheme: a kind of cedar seed nourishes heart the manufacture method of preparation, the described cedar seed preparation that nourishes heart calculates by weight, makes primarily of Semen Platycladi 20-30 part, Radix Codonopsis 20-30 part, Radix Astragali Preparata 90-110 part, Rhizoma Chuanxiong 90-110 part, Radix Angelicae Sinensis 90-110 part, Poria 190-210 part, Radix Polygalae (processed) 20-30 part, Semen Ziziphi Spinosae 20-30 part, Cortex Cinnamomi 20-30 part, Fructus Schisandrae Chinensis (processed with vinegar) 20-30 part, Pinellia leaven 90-110 part, Radix Glycyrrhizae Preparata 5-15 part and Cinnabaris 25-35 part; The nourish heart manufacture method of preparation of described cedar seed is: get Radix Angelicae Sinensis, after soaking 10-30min, decoct, filter, filtering residue adds water extraction again, merges Aqueous extracts, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 55-65% again, reflux, extract, 2-3 time, filters, merging filtrate, and reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and are condensed into extractum, dry, pulverize, and obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add alcoholic solution reflux, extract, 2-4 time of 70%-90%, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds water extraction 2-3 time again, and filter, merging filtrate, after being condensed into concentrated solution, merging with above-mentioned alcohol extract, be condensed into extractum, dry, pulverize, obtain Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add adjuvant, make pharmaceutical preparation.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, the described cedar seed preparation that nourishes heart calculates by weight, makes primarily of Semen Platycladi 25 parts, Radix Codonopsis 25 parts, Radix Astragali Preparata 100 parts, Rhizoma Chuanxiong 100 parts, Radix Angelicae Sinensis 100 parts, 200 parts, Poria, Radix Polygalae (processed) 25 parts, Semen Ziziphi Spinosae 25 parts, Cortex Cinnamomi 25 parts, Fructus Schisandrae Chinensis (processed with vinegar) 25 parts, Pinellia leaven 100 parts, Radix Glycyrrhizae Preparata 10 parts and 30 parts, Cinnabaris; The nourish heart manufacture method of preparation of described cedar seed is: get Radix Angelicae Sinensis, after adding the water soaking 10-30min of 8-12 times amount, decoct 2-3h, filter, filtering residue adds 6-10 times amount water extraction 1-3 time again, each 1-3h, filtration, and merging filtrate is after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 6-10 times amount 55-65% again, reflux, extract, 2-3 time, each 0.5-3h, filter, merging filtrate, reclaims ethanol, obtains alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add alcoholic solution reflux, extract, 2-4 time of 8-12 times amount 70%-90%, each 2-3h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 6-10 times amount water extraction 2-3 time again, each 1-3 hour, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and being concentrated into relative density at 50-60 DEG C is the extractum of 1.1-1.2, dry, pulverize, and obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add adjuvant, make pharmaceutical preparation.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, gets Radix Angelicae Sinensis, and after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add adjuvant, make pharmaceutical preparation.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, and described pharmaceutical preparation is oral formulations.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, and described oral formulations is pill, tablet, capsule or granule.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, and described pill makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decocts 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, every 100g powder refined honey 25-40g adds suitable quantity of water and makes water-honeyed pill, dry, or every 100g powder adds refined honey 100-130g, make small honey pill or big honeyed pills, to obtain final product.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, and described tablet makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decocts 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the starch of the amount of making 10%, with alcohol granulation, tabletting, drying, to obtain final product.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, and described capsule makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decocts 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the starch mixing of the amount of making 10% again, with alcohol granulation, dry, incapsulate, to obtain final product.
Aforesaid cedar seed nourishes heart in the manufacture method of preparation, and described granule makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decocts 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the cane sugar powder mixing of the amount of making 40% again, granulate, dry, to obtain final product.
The present invention makes medicine primarily of Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven, Radix Glycyrrhizae Preparata and Cinnabaris, namely cedar seed nourishes heart preparation, each raw material has good synergism, the preparation made has QI invigorating, nourish blood, the effect of calming the nerves.Can be used for motive deficiency and coldness, palpitation and being susceptible to fright, insomnia and dreamful sleep, forgetful disease such as grade.
The nourish heart manufacture method method of preparation of existing cedar seed is: 12 tastes such as Cinnabaris water flies into impalpable powder, all the other Semen Platycladi are ground into fine powder, with above-mentioned powder facing-up, sieve, mixing, and it is close to add refining, and general ball is dry, to obtain final product.But inventor finds in research process, adopt the cedar seed made in this way and nourish heart in preparation, effectively dividing in medicine not easily measures.Make the nourish heart clinical efficacy of preparation of cedar seed desirable not enough.Inventor also finds in technical study, and adopt the inventive method Radix Angelicae Sinensis and Rhizoma Chuanxiong to be extracted separately, the cedar seed made like this nourishes heart in preparation, and the effective ingredient in medicine is easily measured, and active constituent content in the medicine measured is high.This just makes the refine more of this medicine, and drug effect is more remarkable, and clinical efficacy is good.Therefore this technique facilitates the dissolution rate of the dissolution rate of the effective ingredient in medicine, particularly ferulic acid, and ferulic acid is the important composition of medicine, has very strong pharmacologically active, after the dissolution rate of ferulic acid improves, effectively can improve cedar seed and to nourish heart the drug effect of preparation.
Compared with prior art, the cedar seed that the method for the invention makes nourishes heart in preparation, and the effective ingredient ferulic acid in medicine is easily measured, and the ferulaic acid content measured is high.Effectively can improve cedar seed to nourish heart the drug effect of preparation.
Invention has been a large amount of experimentatioies, is below the result of experimentation of the present invention:
Experimental example 1: ferulaic acid content is investigated
1 instrument and reagent
1.1 mind-easing tonic bolus with arborvitate seed of the present invention, make by the method for embodiment 1.
1.2 existing mind-easing tonic bolus with arborvitate seed: make by following technique:
Prescription: Semen Platycladi 25g, Radix Codonopsis 25g, Radix Astragali Preparata 100g, Rhizoma Chuanxiong 100g, Radix Angelicae Sinensis 100g, Poria 200g, Radix Polygalae (processed) 25g, Semen Ziziphi Spinosae 25g, Cortex Cinnamomi 25g, Fructus Schisandrae Chinensis (processed with vinegar) 25g, Pinellia leaven 100g, Radix Glycyrrhizae Preparata 10g and Cinnabaris 30g.
Technique: 12 tastes such as Cinnabaris water flies into impalpable powder, all the other Semen Platycladi are ground into fine powder, with above-mentioned powder facing-up, sieve, mixing, every 100g powder refined honey 25-40g adds suitable quantity of water and makes water-honeyed pill, dry, or every 100g powder adds refined honey 100-130g, makes small honey pill or big honeyed pills, to obtain final product.
1.3Agilent-1260 high performance liquid chromatograph; Agilent-1260VWD detector; Agilent-C18 (5 μm, 150mm × 4.6mm); MettlerAE240 electronic analytical balance, ferulic acid reference substance (Nat'l Pharmaceutical & Biological Products Control Institute), lacking negative control sample is provided by Hebi City Millennium special medicine Chinese crude drug station.Acetonitrile and phosphoric acid are chromatographically pure, and water is purified water.
2 experimental techniques and result
2.1 chromatographic condition
Agilent-C18 chromatographic column (5 μm, 150mm × 4.6mm), mobile phase: acetonitrile: 0.1% phosphoric acid solution (19:81), determined wavelength is 320nm, column temperature: 35 DEG C, and flow velocity is 1.2mlmin-1, sample size 5 μ l.
The preparation of 2.2 reference substance solution
Precision takes reference substance ferulic acid 12.42mg, and put in the brown measuring bottle of 25ml, add dissolve with methanol, and be diluted to scale, shake up, precision measures 5ml, puts in the measuring bottle of 100ml, adds methanol dilution to scale, shakes up, to obtain final product.
The preparation of 2.3 need testing solutions
2.3.1 the preparation of need testing solution 1
Get mind-easing tonic bolus with arborvitate seed of the present invention appropriate, porphyrize, accurately weighed 1.2g, put in tool plug conical flask, precision adds 70% methanol 25ml, weighed weight, reflux 30min, lets cool, more weighed weight, less loss weight is supplied with 70% methanol, shake up, filter, get subsequent filtrate, filter with 0.45 μm of microporous filter membrane, obtain need testing solution 1.
2.3.2 the preparation of need testing solution 2
Enchashment has mind-easing tonic bolus with arborvitate seed appropriate, porphyrize, accurately weighed 1.2g, put in tool plug conical flask, precision adds 70% methanol 25ml, weighed weight, reflux 30min, lets cool, more weighed weight, less loss weight is supplied with 70% methanol, shake up, filter, get subsequent filtrate, filter with 0.45 μm of microporous filter membrane, obtain need testing solution 2.
The preparation of 2.4 negative control solutions 1: by mind-easing tonic bolus with arborvitate seed prescription proportion of composing of the present invention, get all the other flavour of a drug except Radix Angelicae Sinensis and Rhizoma Chuanxiong, by technological requirement, make the negative sample not containing Radix Angelicae Sinensis and Rhizoma Chuanxiong, press the preparation method of need testing solution 1 again, make negative control solution 1.
The preparation of negative control solution 2 is by existing mind-easing tonic bolus with arborvitate seed prescription proportion of composing, get all the other flavour of a drug except Radix Angelicae Sinensis and Rhizoma Chuanxiong, by technological requirement, make the negative sample not containing Radix Angelicae Sinensis and Rhizoma Chuanxiong, press the preparation method of need testing solution 2 again, make negative control solution 2.
2.5 system suitability test
2.5.1 linear relationship is investigated and is drawn each sample introduction of reference substance solution (24.86 μ g/ml) 0.5,1,5.0,7.5,10 μ l respectively twice, record peak area score value, with ferulic acid integrating peak areas value, sample size is returned, obtain regression curve y=15619.0694x+13.9383, r=0.9999.Result shows that its linear relationship is good, and the range of linearity is: 0.01243 ~ 0.2486 μ g.
2.5.2 precision test precision draws above-mentioned reference substance solution 5 μ l, repeats sample introduction 6 times, measures peak area by above-mentioned chromatographic condition.As a result, RSD=0.26%, shows that instrument precision is good.
2.5.3 replica test respectively precision take mind-easing tonic bolus with arborvitate seed of the present invention and each 6 parts of existing mind-easing tonic bolus with arborvitate seed, according to legal system available test sample solution below " 2.3 " item, by above-mentioned chromatographic condition sample introduction, measure.Result RSD=1.05% and RSD=1.08%, shows that this method repeatability is good.
2.5.4 stability test gets need testing solution 1 and need testing solution 2 respectively, draws 5 μ l, measure integrating peak areas value by above-mentioned chromatographic condition respectively at each precision of 0h, 1h, 2h, 4h, 8h, 12h.Result RSD=0.91% and RSD=0.95%, shows that need testing solution is stable in 12h.
2.5.5 mind-easing tonic bolus with arborvitate seed of the present invention and each 9 parts of the existing mind-easing tonic bolus with arborvitate seed of known content is got in average recovery test respectively, every part of about 1.2g, precise weighing, precision adds a certain amount of ferulic acid reference substance respectively, according to legal system available test sample solution below " 2.3 " item, by above-mentioned chromatographic condition sample introduction 5 μ l, measure, calculate the response rate.Result average recovery rate is 98.67% and 98.55%, RSD=0.99% and RSD=0.10%.
2.6 sample sizes measure
Ferulaic acid content in mind-easing tonic bolus with arborvitate seed of the present invention and existing mind-easing tonic bolus with arborvitate seed is measured by above-mentioned content assaying method.The results are shown in Table 1.
The assay result of table 1 ferulic acid
As known from Table 1, in mind-easing tonic bolus with arborvitate seed of the present invention, the average content of ferulic acid is 0.53mg/ ball, and in existing mind-easing tonic bolus with arborvitate seed, the average content of ferulic acid is 0.32mg/ ball.
Conclusion: compared with existing mind-easing tonic bolus with arborvitate seed, in mind-easing tonic bolus with arborvitate seed of the present invention, the content of the effective ingredient ferulic acid of Radix Angelicae Sinensis and Rhizoma Chuanxiong is higher.In like manner, the preparation of other dosage forms made according to extracting method of the present invention, the active constituent content of Radix Angelicae Sinensis and Rhizoma Chuanxiong also should increase.
Experimental example 2: Effect tests
1 experiment material
1.1 medicine
1.1.1 mind-easing tonic bolus with arborvitate seed of the present invention, with embodiment 1.
1.1.2 existing mind-easing tonic bolus with arborvitate seed, with experimental example 1.
1.2 animal health ICR Strains of Mouses, body weight 18-20g, male and female half and half, are provided by Beijing Vital River Experimental Animals Technology Co., Ltd..
1.3 instrument XZ-4 mice ambulatory activity count devices (institute of Materia Medica,Chinese Academy of Medical Sciences production).
2 methods
Mice is divided into 4 groups at random, often organizes 10, existing mind-easing tonic bolus with arborvitate seed group, blank group, model group and mind-easing tonic bolus with arborvitate seed group of the present invention.Except blank group, every mice sc only injects Levothyroxinnatrium sodium solution 0.4mg/, simultaneously each group mice ig relative medicine 25mL/kg respectively, model group, blank group ig same volume 0.5%CMC-Na solution.Continuous 6d, every day records Mouse Weight, amount of drinking water, when losing weight appears in model group mice, amount of drinking water increases, after the symptom such as restless, yin-deficient model is set up, and then after last administration, mice is put into mice autonomic activities instrument by Latin square order by lh respectively, mice autonomic activities number of times in record 5min.The results are shown in Table 2.
Table 2 on the impact of mice autonomic activities ( ± S, n=10)
Note: compare with blank group, #p<0.01;
Compare with model group, *p<0.05, *p<0.01;
Compare with existing mind-easing tonic bolus with arborvitate seed group +p<0.05.
As seen from table, compare with model group, mind-easing tonic bolus with arborvitate seed group of the present invention, existing mind-easing tonic bolus with arborvitate seed group and blank group ambulatory activity count reduce, therefore mind-easing tonic bolus with arborvitate seed of the present invention and the autonomic activities of existing mind-easing tonic bolus with arborvitate seed to yin vacuity animals all have inhibition, thus play the effect of tranquillizing and allaying excitement, and the effect of mind-easing tonic bolus with arborvitate seed of the present invention is better than existing mind-easing tonic bolus with arborvitate seed.
Detailed description of the invention:
Embodiment 1:
Formula: Semen Platycladi 25g, Radix Codonopsis 25g, Radix Astragali Preparata 100g, Rhizoma Chuanxiong 100g, Radix Angelicae Sinensis 100g, Poria 200g, Radix Polygalae (processed) 25g, Semen Ziziphi Spinosae 25g, Cortex Cinnamomi 25g, Fructus Schisandrae Chinensis (processed with vinegar) 25g, Pinellia leaven 100g, Radix Glycyrrhizae Preparata 10g, Cinnabaris 30g and adjuvant.
Technique: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, every 100g powder refined honey 25-40g adds suitable quantity of water and makes water-honeyed pill, drying, obtains pill.
Usage and dosage: oral, a 6g, 3 times on the one.
Specification: 9g/ ball.
Embodiment 2:
Formula: Semen Platycladi 25g, Radix Codonopsis 25g, Radix Astragali Preparata 100g, Rhizoma Chuanxiong 100g, Radix Angelicae Sinensis 100g, Poria 200g, Radix Polygalae (processed) 25g, Semen Ziziphi Spinosae 25g, Cortex Cinnamomi 25g, Fructus Schisandrae Chinensis (processed with vinegar) 25g, Pinellia leaven 100g, Radix Glycyrrhizae Preparata 10g, Cinnabaris 30g and adjuvant.
Technique: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the starch of the amount of making 10%, with alcohol granulation, tabletting, drying, obtains tablet.
Usage and dosage: oral, a 6g, 3 times on the one.
Specification: 0.5g/ sheet.
Embodiment 3:
Formula: Semen Platycladi 25g, Radix Codonopsis 25g, Radix Astragali Preparata 100g, Rhizoma Chuanxiong 100g, Radix Angelicae Sinensis 100g, Poria 200g, Radix Polygalae (processed) 25g, Semen Ziziphi Spinosae 25g, Cortex Cinnamomi 25g, Fructus Schisandrae Chinensis (processed with vinegar) 25g, Pinellia leaven 100g, Radix Glycyrrhizae Preparata 10g, Cinnabaris 30g and adjuvant.
Technique: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the starch mixing of the amount of making 10% again, with alcohol granulation, dry, incapsulate, obtain capsule.
Usage and dosage: oral, a 3g, every day 3 times.
Specification: 0.5g/ grain.

Claims (9)

1. a cedar seed nourishes heart the manufacture method of preparation, it is characterized in that: the described cedar seed preparation that nourishes heart calculates by weight, makes primarily of Semen Platycladi 20-30 part, Radix Codonopsis 20-30 part, Radix Astragali Preparata 90-110 part, Rhizoma Chuanxiong 90-110 part, Radix Angelicae Sinensis 90-110 part, Poria 190-210 part, Radix Polygalae (processed) 20-30 part, Semen Ziziphi Spinosae 20-30 part, Cortex Cinnamomi 20-30 part, Fructus Schisandrae Chinensis (processed with vinegar) 20-30 part, Pinellia leaven 90-110 part, Radix Glycyrrhizae Preparata 5-15 part and Cinnabaris 25-35 part; The nourish heart manufacture method of preparation of described cedar seed is: get Radix Angelicae Sinensis, after soaking 10-30min, decoct, filter, filtering residue adds water extraction again, merges Aqueous extracts, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 55-65% again, reflux, extract, 2-3 time, filters, merging filtrate, and reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and are condensed into extractum, dry, pulverize, and obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add alcoholic solution reflux, extract, 2-4 time of 70%-90%, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds water extraction 2-3 time again, and filter, merging filtrate, after being condensed into concentrated solution, merging with above-mentioned alcohol extract, be condensed into extractum, dry, pulverize, obtain Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add adjuvant, make pharmaceutical preparation.
2. cedar seed as claimed in claim 1 nourishes heart the manufacture method of preparation, it is characterized in that: the described cedar seed preparation that nourishes heart calculates by weight, makes primarily of Semen Platycladi 25 parts, Radix Codonopsis 25 parts, Radix Astragali Preparata 100 parts, Rhizoma Chuanxiong 100 parts, Radix Angelicae Sinensis 100 parts, 200 parts, Poria, Radix Polygalae (processed) 25 parts, Semen Ziziphi Spinosae 25 parts, Cortex Cinnamomi 25 parts, Fructus Schisandrae Chinensis (processed with vinegar) 25 parts, Pinellia leaven 100 parts, Radix Glycyrrhizae Preparata 10 parts and 30 parts, Cinnabaris; The nourish heart manufacture method of preparation of described cedar seed is: get Radix Angelicae Sinensis, after adding the water soaking 10-30min of 8-12 times amount, decoct 2-3h, filter, filtering residue adds 6-10 times amount water extraction 1-3 time again, each 1-3h, filtration, and merging filtrate is after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 6-10 times amount 55-65% again, reflux, extract, 2-3 time, each 0.5-3h, filter, merging filtrate, reclaims ethanol, obtains alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add alcoholic solution reflux, extract, 2-4 time of 8-12 times amount 70%-90%, each 2-3h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 6-10 times amount water extraction 2-3 time again, each 1-3 hour, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and being concentrated into relative density at 50-60 DEG C is the extractum of 1.1-1.2, dry, pulverize, and obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add adjuvant, make pharmaceutical preparation.
3. cedar seed as claimed in claim 2 nourishes heart the manufacture method of preparation, it is characterized in that: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decocts 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add adjuvant, make pharmaceutical preparation.
4. the cedar seed according to any one of claim 1-3 nourishes heart the manufacture method of preparation, it is characterized in that: described pharmaceutical preparation is oral formulations.
5. cedar seed as claimed in claim 4 nourishes heart the manufacture method of preparation, it is characterized in that: described oral formulations is pill, tablet, capsule or granule.
6. cedar seed as claimed in claim 5 nourishes heart the manufacture method of preparation, it is characterized in that: described pill makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, every 100g powder refined honey 25-40g adds suitable quantity of water and makes water-honeyed pill, dry, or every 100g powder adds refined honey 100-130g, make small honey pill or big honeyed pills, to obtain final product.
7. cedar seed as claimed in claim 5 nourishes heart the manufacture method of preparation, it is characterized in that: described tablet makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the starch of the amount of making 10%, with alcohol granulation, tabletting, drying, to obtain final product.
8. cedar seed as claimed in claim 5 nourishes heart the manufacture method of preparation, it is characterized in that: described capsule makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the starch mixing of the amount of making 10% again, with alcohol granulation, dry, incapsulate, to obtain final product.
9. cedar seed as claimed in claim 5 nourishes heart the manufacture method of preparation, it is characterized in that: described granule makes like this: get Radix Angelicae Sinensis, after adding the water soaking 20min of 10 times amount, decoct 3h, filter, filtering residue adds 8 times amount water extraction 2 times again, each 2h, filters, merging filtrate, after being condensed into concentrated solution, for subsequent use; Filtering residue adds the alcoholic solution of 8 times amount 60% again, reflux, extract, 3 times, each 1h, filters, merging filtrate, reclaim ethanol, obtain alcohol extract, alcohol extract and above-mentioned Aqueous extracts merge, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtain Radix Angelicae Sinensis extract powder, for subsequent use; Get Rhizoma Chuanxiong, add the alcoholic solution reflux, extract, 3 times of 10 times amount 80%, each 2h, filter, merging filtrate, reclaim ethanol, obtain alcohol extract, for subsequent use; Filtering residue adds 8 times amount water extraction 2 times again, each 2 hours, and filter, merging filtrate, after being condensed into concentrated solution, merges with above-mentioned alcohol extract, and when being concentrated into 50-60 DEG C, relative density is the extractum of 1.10-1.20, dry, pulverize, obtains Rhizoma Chuanxiong extractum powder, for subsequent use; Cinnabaris water flies into impalpable powder; Get Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Poria, Radix Polygalae (processed), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (processed with vinegar), Pinellia leaven and Radix Glycyrrhizae Preparata and be ground into fine powder, with above-mentioned eumenol powder, Rhizoma Chuanxiong extractum powder and Cinnabaris impalpable powder facing-up, sieve, mixing, add the cane sugar powder mixing of the amount of making 40% again, granulate, dry, to obtain final product.
CN201510981169.4A 2015-12-23 2015-12-23 Manufacturing method of cedar seed preparation for heart nourishing Withdrawn CN105456591A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108152399A (en) * 2017-12-14 2018-06-12 广东方制药有限公司 A kind of structure and its detection method of seed of Oriental arborvitae medicinal material UPLC characteristic spectrums
CN115844964A (en) * 2022-12-13 2023-03-28 南京同仁堂药业有限责任公司 A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108152399A (en) * 2017-12-14 2018-06-12 广东方制药有限公司 A kind of structure and its detection method of seed of Oriental arborvitae medicinal material UPLC characteristic spectrums
CN108152399B (en) * 2017-12-14 2020-06-16 广东一方制药有限公司 Construction and detection method of UPLC (ultra performance liquid chromatography) characteristic spectrum of semen boitae medicinal material
CN115844964A (en) * 2022-12-13 2023-03-28 南京同仁堂药业有限责任公司 A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases
CN115844964B (en) * 2022-12-13 2023-10-03 南京同仁堂药业有限责任公司 A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases

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