CN101553241A

CN101553241A - Herbal formulation for wound healing

Info

Publication number: CN101553241A
Application number: CNA2007800455594A
Authority: CN
Inventors: 马尼士·萨克沙纳
Original assignee: SUNEV PHARMA SOLUTION Ltd CORP
Current assignee: SUNEV PHARMA SOLUTION Ltd CORP
Priority date: 2006-12-12
Filing date: 2007-11-28
Publication date: 2009-10-07
Also published as: EP2112929B1; MX2009006269A; EP2112929A1; RU2451518C2; BRPI0718326A2; ZA200904843B; US20100178367A1; UA98778C2; CO6190621A2; AU2007331012A1; MY147378A; RU2009126461A; ATE540724T1; KR20090096519A; CA2673212A1; KR101229992B1; JP2010512381A; US9056117B2; NZ578363A; WO2008072256A1

Abstract

The present invention pertains to a herbal formulation with highly potent wound healing properties, in humans and animals. The composition consists of aqueous extracts of Azadirachta indica, in a mixture of natural oils along with herbs viz. Berberis aristata, Curcuma longa, Glycyrrhiza glabra, Jasminum officinale, Picrorhiza kurrooa, Pongamia pinnata, Rubia cordifolia, Saussurea lappa, Terminaliachebula, Trichosanthes dioica, Capsicum and Stellata wild in well-defined ratios. The invention also includes a process for preparing the formulation by extracting the water-soluble components from b ark of Azadirachta indica.

Description

The herb formulation of treatment wound

Following content is described the present invention and preparation method thereof in detail

Technical field

The present invention relates to have the herb formulation of curative effect.Relate in particular to a kind of effectively antibacterium, antifungal is also cured the herb formulation of wound, and it is quite effective to treating human various wound, especially heal sexual trauma and with the wound of decubital ulcer of the difficulty of diabetics.This herb formulation is also quite effective to the healing of wounds in animals.

Background technology

In known prior art, treatment human or animal's common method all relates to several specific steps.They are dilatation and curettage (removing dead/infected tissue), sterilization (with the disinfectant that contains iodine or hydrogen peroxide) and antibiotic therapy (part or whole body, powder, Emulsion or spray form medicine).At last, in order to prevent skin sclerosis and to form duricrust, gauze can be immersed in and contain vaseline, in the fatty acid wetting agent of silicone oil or glycerol.Usually apply sterile gauze on wound and can prevent that not only wound from exposing and be subjected in the environment infection as compositions such as antibacterials, but also can absorb oozing out and secretions of wound.These binders need periodic replacement.Under the hygienic conditions condition that falls behind, for example those often occur in the situation in the undeveloped country, and wound can not get sufficient processing, and is exposed to all the time in dust and the susceptible external environment, and these factors will have a strong impact on the healing of wound.Even carry out effective antimicrobial treatment, and improve relevant supplementary measures, cure wound and still face great challenge.Treatment is also cured invasive infection, wounded by blunt, and the burn that electric power or chemical accident cause, radiation burn etc. also are not very effective, still remain to be improved.In fact, introduce clinical effective antimicrobial agents and also caused the drug resistance of antibacterial fast these medicines.

In the country such as the U.S. of aged tendency of population, patient's leg ulcer has also brought great challenge.In the U.S., the estimated amount of damage that brings because of leg ulcer has 2,000,000 working days.

Except losing working day, the expense for the treatment of these difficult more sexual traumies is also high high.The old people that lower body generally suffers from pressure ulcer (pressure ulcer or decubital ulcer) estimates to be 3-11%.The M ﹠ M of pressure ulcer is quite high.The patient who suffers from pressure ulcer, its mortality rate is bigger 4 times than not suffering from the pressure ulcer patient.In addition, pressure ulcer causes the gerontal patient of septicemia, and its hospital mortality surpasses 50%.Owing to need to strengthen nursing and auxiliary treatment such as resistance to compression device, protection dressing and skin treating, so its medical expense is very expensive.

The wound of diabetics is almost uncontrollable, even is regarded as " incurable disease " usually.In fact, the as easy as rolling off a log initiation leg ulcer of diabetes.The therapy of various treatment leg ulcers, as the repressive bandage systems of multilamellar, local derivative growth factor of recombined human blood platelet carries out skin transplantation etc. with the human body Graftskin and can help wound healing.Yet these therapy costs are huge, and for many patients, these expenses may be unaffordable.And the wound of not curing usually can cause clipping infected limbs.And the treatment of wounds of animal faces more challenge.Different with the mankind, the animal wound is subjected to the chance of external environment invasive infection much higher.Attract people's attention especially be fly particularly fly larvae fly (sarcophagid, calliphorid) or any other class fly (housefly) bite the generation that can further worsen wound and cause complication.In order to prevent the harm of fly, generally be wound area to wounded animals) smear creolin (phenols and blended tars).Though it is wider that this way is used, still there are critical limitations and shortcoming in animal husbandry.It is not only to organizing poisonous and harmful, and the action time of its " prevent and drive away insecticide " is very short, has only one and a half hours.Another kind of therapy in the animal husbandry is that insecticide is directly used wound or the ulcer place that infects by the fly of diving.Except the animal of the acute or chronic poisoning of danger, this therapy will be brought environmental threat, and if animal be made into the product of human consumption, as meat or milk, so also have the risk of contaminated food chain.The present invention eliminates all these risks.

No matter be the human or animal, its Wound healing and bone regeneration and management all are faced with formidable challenges.Existing therapy has limitation to treating and curing some wound in the modern science.For animal, the higher hot conditions of temperature and humidity is that wound and pathological changes have been constituted actual threat, thus this time fly activity very active.This situation also can influence human Wound healing and bone regeneration, and particularly in developing country, sanitary condition there is often qualified inadequately.Facts of life is the danger of the complication brought such as parasitism, antibacterial, especially for the weak and underfed people, and child particularly.

The invention provides a kind of new Chinese medicine composition, it comprises the water extract and the natural oil that is mixed with plurality of herbal of Neem bark.This mixture only can external or local the use, and it has the good antibiotic and characteristic that heals a wound.It is to treatment and cure that those are effective especially at the wound that the prior art people is considered to " incurable disease ".This herb formulation, its powerful effectively antibacterial action is by this mixture, mainly is that the synergism of plant extract is wherein finished.

The invention provides one effectively and cost-effective method treat wound and ulcer.

Discussion to prior art

Disclose some in the prior art and can treat the herb formulation of wound and damage.U.S. Patent application 2006/0134229 discloses a kind of herb formulation that is belonged to the organic extract combination of Japan's variation kind of plant by Fructus Adinae.Invention is special specific aim treatment Skeletal muscle injury and soft tissue healing, and is not only the treatment wound.

PCT application WO2005/115090A2 discloses a kind of Chinese medicine preparation with extremely strong antibiotic and characteristic that heals a wound.This mixture only contains the extract of Ficus and Azadirachta Indica A., forms by the preparing carriers that makes water and organic solvent and medicine can accept form.Key is to use the bark of plant separately.In foregoing invention, in medical herbs mixture, do not add other composition.

Summary of the invention

The invention provides a kind of novel external or the local Chinese medicine preparation that uses, be used for treating and curing various wounds and the damage of the mankind and animal.This Chinese medicine preparation is combined with suitable fixed-ratio really with the natural oil that is mixed with plurality of herbal by the water extract of Azadirachta Indica A. bark.This mixture is in treatment and cure and shown significant curative effect aspect those wounds that are considered to " incurable disease " in the prior art.This Chinese medicine preparation be by the inventor by careful research, the various plants of the most effective treatment wound of finding out extraction mixture.

Goal of the invention

The most basic purpose of the present invention provides a kind of novel herb formulation of curing wound and preparation method thereof.Another purpose provides and a kind ofly can not produce adverse side effect, cheap alternative healing creation therapy.A further object of the invention provides the herb formulation of the simple and easy preparation of a kind of energy.

The specific embodiment

The invention discloses the various wounds of a kind of treatment mankind and animal/damage, thereby need to prevent from the trauma care Chinese medicine preparation of amputation.

An alternative embodiment of the invention is can blood circulation promoting, has the adjusting immunity, has the prescription of antibacterium, antifungal, anti-inflammatory analgesic action in addition.This prescription also can be treated the chronic infection refractory wound that heals, as diabetic foot ulcer, and dried wet gangrene, venous ulcer, varicosis, war wound, burn wound, post-surgical condition etc.

An alternative embodiment of the invention is to be applicable to the local prescription that uses, as is used for skin or outside (eye/ear/nose dropping liquid, gynecological's articles for use etc.).

An alternative embodiment of the invention is the mixture that a kind of prescription is made up of a kind of water extract, a kind of oil-medical herbs mixture and additive.

A) aqueous solution is partly for containing 4-7%, the aqueous solution of preferred 6% Azadirachta Indica A. bark water extract.

B) oil-medical herbs mixture is the blended mixture of ratio such as Oleum Ricini, mustard oil, Oleum Cocois, Semen Sesami Nigrum oil, and 0.5-4%, 12 kinds of medical herbs of preferred 1%, be Berberis thunbergii DC or Radix Berberidis Amurensis, Rhizoma Curcumae Longae (6-9%, preferred 7%), Glycyrrhiza glabra L., Flos Jasmini, Rhizoma Picrorhizae, Indian beech, Radix Rubiae, Saussurea lappa Clarke, the Fructus Chebulae, Pericarpium Trichosanthis (6-9%, preferred 7%), Fructus Capsici and wild Flos nymphaeae (Nymphaea teragona Georgi).

C) suitable additive comprises thickening agent, antiseptic, coloring agent, spice and opacifiers.

Following table is the suitable position of the medical herbs of use in the prescription:

Sequence number	Formal name used at school	The position of using in the prescription
Sequence number	Formal name used at school	The position of using in the prescription	1	Azadirachta Indica A.	Bark
2	The Radix Berberidis Amurensis Berberis thunbergii DC	-Gen	1	Azadirachta Indica A.	Bark
2	The Radix Berberidis Amurensis Berberis thunbergii DC	-Gen	3	Rhizoma Curcumae Longae	Whole root
4	Glycyrrhiza glabra L.	Stem	3	Rhizoma Curcumae Longae	Whole root
4	Glycyrrhiza glabra L.	Stem	5	Flos Jasmini	Whole plants comprises stem, Ye Hehua
6	Rhizoma Picrorhizae	Root stock (stem)	5	Flos Jasmini	Whole plants comprises stem, Ye Hehua
6	Rhizoma Picrorhizae	Root stock (stem)	7	Indian beech	Plant or leaf
8	Radix Rubiae	Stem	7	Indian beech	Plant or leaf
8	Radix Rubiae	Stem	9	Saussurea lappa Clarke	Root stock
10	The Fructus Chebulae	Fruit	9	Saussurea lappa Clarke	Root stock
10	The Fructus Chebulae	Fruit	11	Pericarpium Trichosanthis	Fruit or leaf
12	Fructus Capsici	Fruit	11	Pericarpium Trichosanthis	Fruit or leaf
12	Fructus Capsici	Fruit	13	Wild Flos nymphaeae (Nymphaea teragona Georgi)	Flower

Those skilled in the art can be according to the content of the indivedual compositions of mass content range changing of above-mentioned each composition, so the mass content of indivedual compositions of its reality may be different with above-mentioned content.This is that those skilled in the art can draw by the above-mentioned phase pairing approximation content of each composition in the object of the invention material.All the components can both simple and easyly obtain commercial, and the preparation process of extract is simple, and the last product that obtains provides a kind of cheapness and treat the substituting therapy of wound efficiently, and it can not produce any adverse side effect.

Embodiment 1

The preparation water extract

Take by weighing the bark of Azadirachta Indica A., then with all dirts of the complete flush away of cold water, earth, bad pollutant etc.Add distilled water or deionized water immersion whole night in medical herbs, wherein the dry weight mass ratio of water and medical herbs is 16: 1.Then this mixture is boiled in big fire, and making water evaporates to mixture quality is 1/4 of original quality.Filter out unwanted insoluble substance extracting solution in the extract.So the extract that obtains is the water extract of rufous.

The preparation of oil mixture

Take by weighing 12 kinds of dry medical herbs of appropriate mass by above-mentioned tabulation, clean fully with cold water.Then that their are dry and make Powdered.Two kinds of medical herbs wherein, Rhizoma Curcumae Longae and Fructus Chebulae's dry weight mass content is respectively 7%, and the dry weight mass content of other medical herbs is 1% respectively.Above-mentioned four kinds of oil of quality such as get, mix homogeneously in a container adds pulverous dry medical herbs again in oil mixture.

The preparation of prescription

Water extract is joined in the oil mixing, be heated to moisture and evaporate fully.The result in this step improves heat stability, comes from the water soluble compound of Azadirachta Indica A. bark and other herb extracts together, forms an oily mixed phase.Add thickening agent in the prescription of thermotropism, the mass content of adding is about 1-7%, and preferred 2%.In this prescription, thickening agent is selected Cera Flava for use.In order to prevent that prescription from any deleterious reaction taking place, must add suitable antiseptic.The Arrcostab that comprises P-hydroxybenzoic acid, hydantoin derivatives, propionate salts, potassium sorbate, sodium benzoate.Ancient Hindu medicine text (Ayurveda) has also write down the copper sulfate that uses low concentration.Working concentration is 0.25% copper sulfate in this prescription.Can cool off and use commercial suitable filter to filter this prescription.The prescription of Huo Deing is a yellow green at last.

Embodiment 2

Take by weighing the Azadirachta Indica A. bark of clean dried, add distilled water or deionized water and soak whole night, wherein the dry weight mass ratio of water and medical herbs is 16: 1.Then this mixture is boiled in big fire, and making water evaporates to mixture quality is 1/4 of original quality.Filter out unwanted insoluble substance extracting solution in the extract.So the extract that obtains is the water extract of rufous.

The preparation of oil mixture

Take by weighing the clean dried medical herbs of definite quality by above-mentioned tabulation, make Powdered.With all medical herbs of alcohol extraction, the extract activated carbon decolorizing of acquisition, and filter.In the filtrate of gained, add mixture with equal quality four kinds of oil of mix homogeneously in a container.

The preparation of prescription

Water extract is joined in the oil mixing, be heated to moisture and evaporate fully.The Apis cerana Fabricius that adds mass content 2% in the prescription of thermotropism is as thickening agent, and to add concentration be that 0.25% copper sulfate is as antiseptic.Can cool off and use commercial suitable filter to filter this prescription.The prescription of Huo Deing is generally colourless at last.

Also can additionally add some medical herbs such as antifungal and secondary additive in the preferred embodiment of this described prescription.This additive comprises coloring agent, fragrant section and opacifiers.Also can be plain by adding various dimensions, usually strengthen its effect as A, C and B and various nutrition to skin, the while also can prevent that the moistness of filling a prescription from degenerating as antioxidant.

Claims

1. trauma care prescription comprises:

A.) neem extract of an effective dose;

B.) the plurality of herbal extract of an effective dose and oil and sneak into multiple additives, its Chinese herbal medicine is selected from Berberis thunbergii DC, Rhizoma Curcumae Longae, Glycyrrhiza glabra L., Flos Jasmini, Rhizoma Picrorhizae, Indian beech, Radix Rubiae, Saussurea lappa Clarke, Fructus Chebulae, Pericarpium Trichosanthis, Fructus Capsici and wild Flos nymphaeae (Nymphaea teragona Georgi), additive comprises thickening agent, antiseptic, coloring agent, depigmenting agent, spice, opacifiers and vitamin, it is characterized in that neem extract is a water extract, and those medical herbs are oil or ethanol extraction, they are mixed into described prescription with the ratio of Synergistic.

2. prescription as claimed in claim 1 is characterized in that:

A.) to be used to prepare the suitable part of water extract be the bark of Azadirachta Indica A. to Azadirachta Indica A.;

B.) the suitable part of the medical herbs that uses in the prescription is respectively: the root of Berberis thunbergii DC or Radix Berberidis Amurensis, the stem of Glycyrrhiza glabra L., the whole plants of Flos Jasmini, comprise stem, Ye Hehua, the root stock of Rhizoma Picrorhizae, the kind of Indian beech or leaf, the stem of Radix Rubiae, the root stock of Saussurea lappa Clarke, Fructus Chebulae's fruit, the fruit of Pericarpium Trichosanthis or leaf, fruit of Fructus Capsici and the flower of wild Flos nymphaeae (Nymphaea teragona Georgi), mix with four kinds of oil, be respectively Oleum Ricini, mustard oil, Oleum Cocois and Semen Sesami Nigrum oil;

C) additive that uses in preparation process is: as the copper sulfate of antiseptic, and as the Cera Flava of thickening agent, as the active carbon or the bleaching earth of depigmenting agent, D-calcium saccharate, Se Luolite (Serolite), bentonite or magnesium oxide.

3. prescription as claimed in claim 2 is characterized in that:

A.) the water extract concentration of Azadirachta Indica A. is 4-7% in the prescription;

B.) concentration of other natural herbal is in the prescription: Berberis thunbergii DC or Radix Berberidis Amurensis, Glycyrrhiza glabra L., Flos Jasmini, Rhizoma Picrorhizae, Indian beech, Radix Rubiae, Saussurea lappa Clarke, Fructus Chebulae, Pericarpium Trichosanthis, Fructus Capsici and wild Flos nymphaeae (Nymphaea teragona Georgi) are 0.5%-4% respectively, and Rhizoma Curcumae Longae and Pericarpium Trichosanthis are respectively 6%-9%, and four kinds of oil are to wait ratio blended in the prescription;

C.) mass concentration of copper sulfate is 0.1-0.5% in the prescription, and mellisic mass concentration 1-7%.

4. one kind prepares the method for prescription according to claim 1, it is characterized in that may further comprise the steps:

-with 16: 1 mixing waters of mass ratio and exsiccant Azadirachta Indica A. bark, boil this mixture, making water evaporates to mixture quality is 1/4 of original quality, and filters and obtain its water extract,

-etc. quality mix Oleum Ricini, mustard oil, Oleum Cocois and Semen Sesami Nigrum oil, in miscella, add the medical herbs Berberis thunbergii DC of appropriate amount, Rhizoma Curcumae Longae then, Glycyrrhiza glabra L., Flos Jasmini, Rhizoma Picrorhizae, Indian beech, Radix Rubiae, Saussurea lappa Clarke, Fructus Chebulae, Pericarpium Trichosanthis, dried powder of Fructus Capsici and wild Flos nymphaeae (Nymphaea teragona Georgi) or ethanol extraction obtain Herba Leptochloae Chinensis medicine mixture.

-with the water extract and the oil-medical herbs mixture of 4: 1 ratio mixing Azadirachta Indica A., boil to moisture and evaporate fully, then add thickening agent, antiseptic, deodorizer, coloring agent, perfume, opacifiers and vitamins additive.

5. prescription as claimed in claim 1 is used to prevent to carry out amputation.

6. above-mentioned prescription is used for the treatment of wound.