CN102133326B - Preparation for repairing skin mucosa - Google Patents
Preparation for repairing skin mucosa Download PDFInfo
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- CN102133326B CN102133326B CN201110075494A CN201110075494A CN102133326B CN 102133326 B CN102133326 B CN 102133326B CN 201110075494 A CN201110075494 A CN 201110075494A CN 201110075494 A CN201110075494 A CN 201110075494A CN 102133326 B CN102133326 B CN 102133326B
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Abstract
The invention relates to a preparation for repairing skin mucosa, which is prepared according to the following steps of: crushing purslane, pig nail and pepper into powder; smashing garlic into paste; putting the powder and the paste into sesame oil, and mixing and stirring uniformly; hermetically soaking, and then, carrying out suction filtration; and taking clear liquid to obtain the preparation. The preparation can be used for effectively treating skin mucosa ulcers and pyogenic infected wounds.
Description
Technical field
The present invention relates to a kind of preparation that is used to repair skin mucosa.
Background technology
Skin mucosa ulcer is meant the skin mucosa chronic infection ulcer that a variety of causes causes, is a kind of commonly encountered diseases, frequently-occurring disease, seriously influences patient's body health.Mostly the reparation of traditional skin mucosa is that adding the part with the antibiotic antiinflammatory changes dressings, and its course of treatment is long and therapeutic effect is poor.At present in the face of the obstinate skin ulcer that is difficult to cure or fester, it is painful helpless that therefore the patient usually seems, therefore the medical worker usually seems at a loss what to do.In patent documentation, also disclose the medicine of some treatment skin mucosa ulcer, but also do not obtained extensive use usually because of curative effect.
Summary of the invention
The purpose of this invention is to provide a kind of preparation that is used to repair skin mucosa, with effective treatment skin mucosa ulcer and pyogenic infection wound.
The preparation that is used to repair skin mucosa according to the invention is to get by following method preparation:
Herba Portulacae, Unguis Sus domestica, Zanthoxyli Bungeani powder are broken into powder; After Bulbus Allii is mashed into mud, put into Oleum Sesami, the percentage by weight of each component is: Herba Portulacae 6～12%, Unguis Sus domestica 4～12%, Pericarpium Zanthoxyli 3～12%, Bulbus Allii 4～12%; Surplus Oleum Sesami; Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii mixed stirring in Oleum Sesami, airtight dipping back sucking filtration is got clear liquor and is promptly got.
Before Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii are put into Oleum Sesami, Oleum Sesami is heated to boils earlier, put into Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli and Bulbus Allii again after being cooled to 55～70 ℃.
Airtight dip time is 7～14 days, and stir macerate once preceding 6～13 day every day.
Herba Portulacae (monarch): be Portulacaceae annual herb plant Portulaca oleracea L..Large intestine, liver, spleen three warps are returned in acid, cold, have heat-clearing and toxic substances removing, and the blood detumescence of loosing is controlled the hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula.Be used for diarrhoea, dysentery due to damp and hot, often join Rhizoma Coptidis, the Radix Aucklandiae.For oral administration or smash the juice external application, control carbuncle.Also be used to have blood in stool, metrorrhagia, anastalsis is arranged.Conventional use: cure mainly diseases such as hygropyretic dysentery and pathopyretic ulcer.Short ulcer healing effect: national Chinese herbal medicine compilation report, these article contain abundant vitamin A appearance material, can promote epithelial physiological function to be tending towards normal.
Unguis Sus domestica (minister): be the Bauhinia variegata Linn of porcine animals pig Sus scrofa domestica brisson, claim that again pig dewclaw, pig move back etc., be beneficial to stripping, must fry to bubble crisply, be beneficial to pulverizing for making composition.Shennong's Herbal record: " latent heat is lost in the acute appendicitis at intestinal for dewclaw, main five hemorrhoid ".The Compendium of Material Medica record: " Unguis Sus domestica master five hemorrhoid ... with the Ramulus et Folium Bischofiae Javanicae ashing, smoked all malignant boil of warding off "." Bencao Congxin " pointed out: " pig dewclaw first is controlled the cold and heat phlegm dyspnea, and variola is gone into order, five hemorrhoid acute appendicitis ".In recent years clinical and experimentation shows that Unguis Sus domestica alternative Squama Manis on the lactogenic effect is medicinal.The Squama Manis medicinal part is a scute, and is completely different with Unguis Sus domestica, but ingredient is roughly similar, all contains a large amount of aminoacid, inorganic matter, steroid class etc.
Bulbus Allii (minister): be the Liliaceae herbaceous plant, detoxifcation, eliminating carbuncle, parasite killing are mashed into cement paste, more help the leaching of active ingredients such as Bulbus Allii volatile oil, garlicin.Modern pharmacological research confirms that Bulbus Allii contains allicin, allicin etc.Allicin has stronger antibacterial action, and multiple coccus, bacillus, virus, fungus etc. are all had killing action.
Pericarpium Zanthoxyli (assistant): be dry mature skin and the seed of rutaceae green pepper Zanthoxylum schinifolium Sieb. et Zucc. or Pericarpium Zanthoxyli Zanthoxylum bungeanum Maxim..The antibacterial pain relieving has remarkable inhibitory action to staphylococcus aureus, bacillus pyocyaneus.Press 2000 editions regulations of Chinese Pharmacopoeia, be used as medicine, but, possibly more can heighten the effect of a treatment, so in this preparation, only require removal fruit stem, impurity because of said preparation all uses peel and Semen zanthoxyli (seed) in clinical use jointly always only for its peel.Be broken into coarse powder and make oil cell broken, more can strengthen the effective ingredient stripping.
Oleum Sesami (making): the fatty oil that squeezes for the seed of Pedaliaceae plant sesame Sesamum indicum DC..The antiinflammatory skin moistening is a solvent, is again adjuvant simply, and is purer for making it, do not carry disease germs, so before putting into Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii, should earlier Oleum Sesami be heated to and boil with antibacterial.Because of Bulbus Allii, Pericarpium Zanthoxyli all contain the volatile oil about 2.0%, should not be too high so add fashionable oily temperature, when oily temperature drop to 55～70 ℃, add, can avoid the volatile component of medicine to decompose and loss.Regularly stir, pharmaceutical compositions can fully be immersed in the Oleum Sesami.
Character, the function that is used to repair the preparation of skin mucosa according to the invention cure mainly and usage and dosage following:
1, character: be tenne translucent oily liquids, gas is fragrant.
2, function cures mainly: the parasite killing detoxifcation, and the antiinflammatory skin moistening, putrefaction-removing granulation-promoting promotes the skin ulcer healing, is mainly used in treatment skin mucosa ulcer and pyogenic infection wound.
3, usage and dosage: oral: take before 10ml sleeps, take the water of not taking food in preceding 2 hours.
External: be applied to mucocutaneous affected part, 1-2 time/day, or follow the doctor's advice.
One, preparation preliminarily stabilised property of the present invention test
1, test method and condition:
Get three batches in preparation of the present invention; The preparation lot number is 20030306,20030515,20030710, the room temperature reserved sample observing, and the test period room temperature is 16-21 ℃; Relative humidity is 70-86%; Respectively at 0,1,2, the sampling in March, investigate with quality standard draft defined method with clinical research, microbial limit is pressed 2000 editions appendix VIII of Chinese Pharmacopoeia C " microbial limit test " and is checked.
2, inspection item and result:
20030306), table 2 (preparation lot number: 20030515), table 3 (preparation lot number: 20030710) by the inspection on time one by one of aforesaid standards predetermined items, its result sees table 1 (preparation lot number: for details.
Table 1: lot number is the preliminarily stabilised property test report of 20030306 preparation
Table 2: lot number is the preliminarily stabilised property test report of 20030515 preparation
Table 3: lot number is the preliminarily stabilised property test report of 20030710 preparation
3, conclusion:
Preliminary stability test was investigated through three months; The March that the result shows three batches of products respectively with its 0 month relatively; Except that the outward appearance character jog appears and the microprecipitation of be prone to loosing, all the other discriminatings, inspection, assay and limit test of microbe have no significant change, and be up-to-standard.The quality that preparation of the present invention is described is a stable and controllable.
Two, preparation pharmacodynamic experiment of the present invention
1, experiment material:
1.1 experiment medicine: preparation of the present invention: every ml contains the 0.74g crude drug, lot number is provided: 030411 by applicant of the present invention; Formaldehyde (A.R.): Beibei District, Chongqing City chemical reagent factory, lot number: 20000624.The new liquid of rehabilitation: main component (periplaneta america), Kunming Sainuo Pharmaceutical Co., Ltd., lot number: 021211101.Oleum Tiglii: the research department provides by the Chongqing Institute of Chinese Medicine medicine.Prednisone: fairy house Pharmacy stock Co., Ltd, lot number; 0220816.Oleum Terebinthinae: Hunan Huaihua area pharmaceutical factory, lot number: 020826.
1.2 laboratory animal: mice (Kunming kind), rat (Wistar), Japanese big-ear white rabbit; Be one-level animal (authentication code: No. the 310101001st, 310101002,310101003, the moving word of doctor), provide by Animal Experimental Study chamber, Chongqing Institute of Chinese Medicine.
2, method and result:
2.1 influence to experiment type skin ulcer
[1]
Select for use body weight about 1.8～2.5kg, 19 of healthy, rabbit that skin is harmless, the male and female dual-purpose is divided into 5 groups at random.Cut off the back and become mildewed, slough undercoat with 10% sodium sulfide, expose the about 4cm of skin diameter, central part is with the prepared Chinese ink labelling.Behind the routine disinfection, from the aseptic Oleum Terebinthinae 0.7ml/ of mark subcutaneous (SC) injection only by the sterile working.Behind the 24h be that center of circle annular is cut holostrome skin with the gauge point, radius is 1cm, and the wrapping of postoperative sterile gauze by the 1 time/d that changes dressings of sterile working, is healed until ulcer surface.Formulation components of the present invention do not smear finished product 0.4 ml/ only, 0.2ml/ only, 0.1 ml/ only; Positive controls is only smeared new liquid 0.4 ml/ of rehabilitation; The excipient group is only smeared Oleum Sesami 0.4 ml/; , model group smears normal saline 0.4 ml/ only, 1 time/d, successive administration 15d.
1h after the last administration, the sacrificed by exsanguination animal is drawn materials from ulcer central authorities and to send disease inspection.50 visuals field of microscopy at random:
(1) ulcer surface necrosis and exudate situation;
(2) new vessels situation in the granulation tissue;
(3) fibroblast quantity and size;
(4) fibroblast generates the situation of collagen fiber;
(5) inflammatory edema situation;
(6) inflammatory cell infiltration degree in the granulation tissue;
(7) the newborn and covering situation of epidermis.Judge preparation action intensity of the present invention according to above-mentioned standard.
The result sees table 1:
Table 1 preparation of the present invention is to the histological examination that influences of rabbit skin ulcer
The result shows that model group and vehicle group postoperative 15d skin ulcer tissue slice show: ulcer surface necrosis and exudate are more; New vessels is less in the granulation tissue; Fibroblastic negligible amounts, cell space is less; Fibroblast generation collagen fiber and substrate are less; Granulation tissue is thinner; Inflammatory edema is more obvious in the granulation tissue; Inflammatory cell is more in the granulation tissue; Epidermis new life and covering owe active.Heavy dose of group, middle dose groups, small dose group and positive drug matched group postoperative 15d skin ulcer tissue slice show: ulcer surface necrosis and exudate are less; New vessels is more in the granulation tissue; Fibroblastic quantity is more, and cell space is bigger; Fibroblast generation collagen fiber and substrate are more; Granulation tissue is thicker; Inflammatory edema is not obvious in the granulation tissue; Inflammatory cell is less in the granulation tissue; Epidermis is newborn and cover more active.Wherein, heavy dose is organized, middle dose groups is close with positive controls each item index, and small dose group is poor slightly.Point out preparation of the present invention that the healing of experiment type skin ulcer is had obvious facilitation.
2.2 influence to Oleum Tiglii induced mice ear swelling
[2]
Select 50 of body weight 20 ± 2g mices, male and female half and half are divided equally 5 groups (n=10) at random.Preparation group of the present invention is smeared finished product 10.0ml/kg, 5.0ml/kg, 2.5ml/kg respectively at mouse right ear, and positive controls is smeared the new liquid 10.0ml/kg of rehabilitation, and matched group is smeared Oleum Sesami 10.0ml/kg, smears 3d continuously.60min after the last administration wipes with cotton balls and to be tried thing, only is coated with Oleum Tiglii proinflammatory agent 0.05ml/ at every Mus auris dextra tow sides then; Behind the 4h, take off cervical vertebra and put to death mice, cut ears; Lay auricle with 8mm diameter card punch at same position, on torsion balance, weigh respectively, with about two ear auricle weight differences be the swelling value; Check the significance of preparation group of the present invention and matched group effect with t, the result sees table 2:
Table 2 preparation of the present invention is to the influence of Oleum Tiglii induced mice ear swelling (x ± s)
Annotate: compare * < 0.05 * * < 0.01 with matched group
Table 2 prompting, preparation of the present invention have the inhibitory action (P < 0.05～0.01) of highly significant to Oleum Tiglii induced mice ear swelling.
2.3 the influence of rat paw edema due to the on Carrageenan
[3]
Select 50 of body weight 180～250g rats, male and female half and half are divided into 5 groups (n=10) at random.Formulation components of the present invention is not irritated clothes finished product 10.0 ml/kg, 5.0 ml/kg, 2.5 ml/kg, and positive controls is irritated clothes prednisone 25mg/kg, and matched group is irritated clothes Oleum Sesami 10.0 ml/kg, 1 time/d of administration, 3d continuously.30min after the last administration; Only cause inflammation at every Mus right hind foot plantar subcutaneous injection 1% carrageenin suspension 0.1ml/; After administration 1,2,3,4,6h is with special transparent tape amount ankle joint girth, according to formula: ankle joint girth * 100% before swelling rate (%)=(cause scorching back ankle joint girth-cause scorching before ankle joint girth)/cause is scorching; Suppression ratio (%)=(the average swelling rate of the matched group-average swelling rate of preparation the group of the present invention)/average swelling rate of matched group * 100%.Check the significance of drug group and matched group effect with the t value, the result sees table 3:
The influence of rat paw edema due to the table 3 preparation on Carrageenan of the present invention (X ± S)
Annotate: compare with matched group, < < < in 0.001 " () " is suppression ratio to 0.01 * * * P to 0.05 * * P to * P.
Table 3 shows, rat paw edema has the inhibitory action (P < 0.05～0.01) of significance due to the preparation on Carrageenan of the present invention, and is dose-effect relationship, and heavy dose of group (7.4g/>kg) effect is more remarkable, and it is also longer to hold time.
2.4 the influence of PARA FORMALDEHYDE PRILLS(91,95) induced mice pain reaction
[4]
Select 50 of body weight 20 ± 2g mices, male and female half and half are divided equally 5 groups (n=10) at random.Under the front foot butt on every Mus right side, inject 2.5% formalin 0.03ml; Be coated with preparation 10.0ml/kg of the present invention, 5.0 ml/kg, 2.5 ml/kg then respectively, positive controls is coated with new liquid 10.0 ml/kg of rehabilitation, and matched group is coated with Oleum Sesami 10.0 ml/kg; Behind the administration 10min; Every Mus places volume 2000ml beaker respectively, observes 50min, and record is every to react highest score at a distance from the interior pain of 10min.
Criterion:
" 0 " is divided: the front foot of injection and the equal kiss the earth of not injecting of front foot, walk about freely;
" 1 " is divided: the slight kiss the earth of the front foot of injection, body wt move on to does not inject a side, obviously walks lamely when walking about;
" 2 " are divided: the front foot of injection lifts, and does not contact any ground;
" 3 " are divided: mice licks, stings or the front foot of jitter injection.
The front foot of injection formaldehyde reaction in 2 fens do not occur and has been judged to analgesic activity.With the significance of t value check drug group and matched group effect, the result sees table 4:
The influence of table 4 preparation PARA FORMALDEHYDE PRILLS(91,95) of the present invention induced mice pain reaction
Annotate: compare * P < 0.05 ﹡ * * P < 0.01 ﹡ * * * P < 0.001 with matched group
Table 4 explanation, the pain reaction of the preparation PARA FORMALDEHYDE PRILLS(91,95) induced mice foot sole of the foot of the present invention has the inhibitory action of highly significant
(P〈0.05～0.01>。
3, conclusion:
Preparation of the present invention is through clinical 320 routine clinical researches, and cure rate is 94.69%.Be the pharmacodynamic action of this medicine of objective science evaluation, we have carried out the pharmacodynamic study of this medicine.The result shows that preparation of the present invention has obvious facilitation to experiment type skin mucosa ulcer healing.Preparation of the present invention all has the inhibitory action (P ﹤ 0.05～0.001) of significance to rat paw edema due to Oleum Tiglii induced mice ear swelling and the on Carrageenan; Preparation of the present invention has significant analgesia role, experimentation and clinical research basically identical.
4, list of references:
[1] Wei Zhendong, Guo Sicheng, Sun Jianhua. the Chinese medicine powder medicine for removing necrotic tissue and promoting muscle growing promotes zoopery type skin
The pharmaceutical research of ulcer repair [J]. Tianjin medicine, 1990, (9): 547.
[2] Xu Shuyun chief editor. pharmacological experimental methodology [M]. People's Health Publisher, 1985,525.
[3] Qi Chen chief editor. herbal pharmacology research methodology [M]. People's Health Publisher, 1994,364.
[4] Liu Xuejun, Zhu Xiaodong, Tang Xican. a kind of method of easy screening analgesic---aldehyde test [J]. Acta Pharmaceutica Sinica, 1985, (12): 716.
Three, the toxicological experiment of preparation of the present invention
1, experiment material:
1.1 experiment medicine preparation oil preparation of the present invention: every ml contains the 0.74g crude drug, lot number is provided: 030411 by applicant of the present invention.
1.2 laboratory animal mice (Kunming kind), Japanese big-ear white rabbit are one-level animal (authentication code: No. the 310101001st, 310101002,310101003, the moving word of doctor), provided by Animal Experimental Study chamber, Chongqing Institute of Chinese Medicine.
2, method and result:
2.1 acute toxicity testing
[1]Select 60 of body weight 20 ± 2g mices for use, male and female half and half are divided equally 3 groups (n=20) at random.Before the experiment, water 16h is can't help in the mice fasting.Formulation components of the present invention is not irritated clothes finished product 0.8ml/20g * 1 time/d, 0.6ml/20g * 2 time/d (6h at interval); Matched group is irritated clothes normal saline 0.8ml/20g * 1 time/d, and the situation such as appetite, spontaneous activity, feces, body weight and death of 7d mice behind the observation medicine if any dead mouse, are made pathology to its dissection and observed.The result sees table 5:
Table 5 preparation of the present invention is to the influence of mice body weight (x ± s)
The result shows, to 2 filling clothes preparation 0.6ml/20g of the present invention * 2 times/d within 1 property of mice filling clothes preparation 0.8ml/20g of the present invention and the 1d, is respectively 240,360 times of clinical daily dose.Irritate clothes administration 40min, mice has diarrhoea phenomenon in various degree to take place, and recovers normal behind the 23h.Observe through 7d, mice appetite, outward appearance, spontaneous activity, feces, growth promoter (body weight) are not seen obvious influence, none dead mouse.Results suggest, preparation toxicity of the present invention is lower.
2.2 influence to normal skin and damaged skin
[1]Select 8 of body weight 1.8-2.5kg rabbit for use, male and female half and half are divided equally 2 groups (n=4) at random.Cut off the back and become mildewed, slough undercoat with 10% sodium sulfide solution then, the about 16cm of area
2One treated animal is a normal skin, and every animal is smeared preparation 1ml of the present invention, 1 time/d, and continuous 7d.Another treated animal is that (make "+" word otch with aseptic operation, otch is about 3cm to damaged skin, gos deep into flesh layer 1-2mm), and every animal is smeared preparation 1ml of the present invention, and 1 time/d, 7d marks according to standards of grading continuously.
Skin irritation reaction standards of grading:
IR: erythema: no erythema 0 minute, visible 1 minute reluctantly, obviously visible 2 minutes, moderate is to serious erythema 3 minutes, aubergine erythema and eschar formation edema 4 minutes are arranged.Edema: no edema 0 minute, visible 1 minute reluctantly, slight visible (slightly exceeding surrounding skin) 2 minutes; The about 1mm of skin, clear 3 minutes of profile; More than the edema protuberance 1mm, and expanded range 4 minutes.
Skin irritation intensity standards of grading:
Nonirritant 0-0.4 branch; Slight zest 0.5-1.9 branch; Moderate zest 2.0-5.9 branch; Strong and stimulating 6.0-8.0 branch.
The result shows that preparation of the present invention is not all seen tangible stimulation to normal skin and damaged skin, and score value is 0 minute.
3, conclusion:
Preparation of the present invention is not found toxic and side effects through 320 routine clinical researches, and for objective science confirms whether toxic side effect of this medicine, we have carried out toxicologic study again.The result shows, to 1 property of mice filling clothes skin clever 0.8ml/20g and 0.6ml/20g * 2 time/d that bursts, is equivalent to 240,360 times of clinical daily dose respectively, and the 40min mice has the laxativeness phenomenon after administration, does not have other abnormal conditions.Observe through 7d, spontaneous activity in mice, appetite, stool, body weight are not all had obvious influence, results suggest preparation toxicity of the present invention is lower.Preparation of the present invention is not seen tangible stimulation to rabbit normal skin and damaged skin, and the stimulus intensity score value is 0 minute.Consistent with clinical research.
4, reference material
[1] bureau of drug policy & administration of Ministry of Health of the People's Republic of China. traditional Chinese medical science new drug toxicologic study guide, 203,209.
Four, preparation clinical observation of the present invention
Use preparation repairing and treating skin mucosa ulcer patient 320 examples of the present invention, and with the rehabilitation of Kunming Sainuo Pharmaceutical Co., Ltd. newly to 120 routine patient treatments contrasts, satisfactory effect, sum up as follows:
1, case is selected:
1.1 all a variety of causes of the standard of including in cause the skin ulcer of (trauma infection contamination, burn and scald, decubital ulcer, diabetes, varicose veins of the lower extremity etc.), all as the clinical observation object.
1.2 skin ulcer due to the exclusion standard skin carcinoma.
2, clinical data:
2.1 physical data
This organizes 320 examples, male 206 examples, women 114 examples; Occupation: workman's 96 examples, peasant's 125 examples, soldier's 18 examples, cadre's 15 examples, at loose ends 66 examples; Age: minimum 4 years old, maximum 71 years old; The course of disease: 15～90d, average 38.3d; Ulcer area: minimum 0.5cm
2, maximum 30 ㎝
2Ulcer: extremity ulcer 176 examples, other position 144 examples; The cause of disease: trauma infection contamination forms ulcer 147 examples, and burn and scald causes local ulcer 75 examples, and lower limb vasculitis and other reason cause local ulcer 98 examples.According to group 120 examples, male 84 examples, women 36 examples; Occupation: workman's 51 examples, peasant's 20 examples, soldier's 15 examples, cadre's 20 examples, at loose ends 14 examples; Age: minimum 6 years old, maximum 69 years old; The course of disease: 15～76d, average 31.5; Ulcer area: minimum 0.5cm
2, maximum 27 ㎝
2Ulcer: extremity ulcer 99 examples, other position 21 examples; The cause of disease: trauma infection contamination forms ulcer 105 examples, and other reason causes local ulcer 15 examples.
2.2 Therapeutic Method
Preparation of the present invention is the pathogeny according to skin ulcer, clinical manifestation, and according to the principles of formulating prescriptions of the traditional Chinese medical science, selected Herba Portulacae, Unguis Sus domestica, Bulbus Allii, Pericarpium Zanthoxyli, Oleum Sesami are formed.Take the method for comparative study at random.320 examples are organized in treatment, use preparation of the present invention.Method: clean wound surface with 3% hydrogenperoxide steam generator earlier; With normal saline flushing, cut off slough in case of necessity again, dry normal saline with disinfecting cotton swab or gauze then after; With cotton swab preparation of the present invention is coated wound surface equably; Being close to the wound surface layer is formulation oils meche of the present invention, and the reuse sterile gauze applies lid, fixing.1-2 time/the d that changes dressings can take the circumstances into consideration to adjust dressing change frequency according to ulcer area size and traumatic infection degree, treats that can change 2 d into after the infection control changes dressings 1 time.Matched group 120 examples are with the new liquid of the rehabilitation of Kunming Sainuo Pharmaceutical Co., Ltd..Method is with the treatment group.
3, result:
3.1 criterion of therapeutical effect
Recovery from illness: ulcer surface heals fully;
Produce effects: the ulcer area dwindles more than 75%;
Effectively: the ulcer area dwindles 25%-75%;
Invalid: the ulcer area dwindles < 25%.
3.2 observation of curative effect
Preparation group of the present invention is changed dressings and is cured 221 examples (69.06%) in 10 times, changes dressings and cure that no change is invalid 17 examples (5.31%) after 82 examples (25.63%), 20 times, cure 303 examples (94.69%) in 20 times; Matched group is changed dressings and is cured 70 examples (58.33%) in 10 times, changes dressings and cure 32 examples (26.67%) in 20 times, and no change 18 examples (15.00%) after 20 times of changing dressings are cured 102 examples (85.00%).Compare for two groups, treatment group cure rate is higher by 9.69% than matched group.
4, conclusion:
In the preparation of the present invention, Herba Portulacae cures mainly diseases such as pathopyretic ulcer, short ulcer healing effect: national Chinese herbal medicine compilation report, these article contain abundant vitamin A appearance material, so can promote epithelial physiological function to be tending towards normal.Unguis Sus domestica has the effect of " warding off all malignant boil " (Compendium of Material Medica).Bulbus Allii detoxifcation parasite killing, moisture has reducing swelling and alleviating pain, the merit of treatment malignant boil.Modern medicine study shows that Bulbus Allii contains allicin, allicin etc., and allicin has stronger antibacterial action, and multiple coccus, bacillus, virus, Buddhist nun are restrained time body, fungus, ameba etc. all has killing action
[1]Pericarpium Zanthoxyli merit tool warming spleen and stomach for dispelling cold, pain relieving, antibacterial, contained volatile oil has the local analgesia effect.Experimentation also shows, Pericarpium Zanthoxyli has good inhibitory effect to gram negative bacterias such as gram positive bacterias such as staphylococcus aureus, Diplococcus pneumoniae and escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, bacillus pyocyaneus in vitro
[1]The merit that Oleum Sesami is remembered in Compendium of Material Medica one book to be had and control " all malignant boil scabies, kill all worms " reach " granulation promoting put on flesh pain relieving, swollen, the benefit rhagades of the skin of the pain that disappears ".All medicines share, and have embodied preparation of the present invention and have had very strong infection, putrefaction-removing granulation-promoting, analgesic effect.Show that through clinical research cure rate reaches 94.69%, do not find toxic and side effects.
4, list of references
[1] the new medical college in Jiangsu is compiled Chinese medicine voluminous dictionary (first volume), Shanghai: the Shanghai People's Press, 1977,1110.
The specific embodiment
Embodiment one:
Being used to repair the preparation of skin mucosa, is to get by following method preparation:
With being ground into powder after the Herba Portulacae oven dry; Unguis Sus domestica is cleaned, and removes adherent meat skin, and stir-baking with sand is ground into powder after steep shortcake; Pericarpium Zanthoxyli is ground into powder after removing fruit stem, impurity; After only Bulbus Allii peeling of purple skin, mash into mashed garlic; Oleum Sesami is heated to boils, be cooled to 70 ℃ after, put into Herba Portulacae, Unguis Sus domestica and Pericarpium Zanthoxyli that is ground into powder and the Bulbus Allii of mashing into mud; Wherein, the percentage by weight of each component is: Herba Portulacae 6%, Unguis Sus domestica 12%, Pericarpium Zanthoxyli 7%, Bulbus Allii 8%, Oleum Sesami 67%; Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii mixed stirring in Oleum Sesami, airtight dipping, stir macerate once preceding 6 day every day; Flood sucking filtration after 7 days, get the clear liquor packing and promptly get.
Embodiment two:
Being used to repair the preparation of skin mucosa, is to get by following method preparation:
With being ground into powder after the Herba Portulacae oven dry; Unguis Sus domestica is cleaned, and removes adherent meat skin, and stir-baking with sand is ground into powder after steep shortcake; Pericarpium Zanthoxyli is ground into powder after removing fruit stem, impurity; After the Bulbus Allii peeling, mash into mashed garlic; Oleum Sesami is heated to boils, be cooled to 55 ℃ after, put into Herba Portulacae, Unguis Sus domestica and Pericarpium Zanthoxyli that is ground into powder and the Bulbus Allii of mashing into mud; Wherein, the percentage by weight of each component is: Herba Portulacae 12%, Unguis Sus domestica 4%, Pericarpium Zanthoxyli 3%, Bulbus Allii 12%, Oleum Sesami 69%; Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii mixed stirring in Oleum Sesami, airtight dipping, stir macerate once preceding 13 day every day; Flood sucking filtration after 14 days, get the clear liquor packing and promptly get.
Embodiment three:
Being used to repair the preparation of skin mucosa, is to get by following method preparation:
With being ground into powder after the Herba Portulacae oven dry; Unguis Sus domestica is cleaned, and removes adherent meat skin, and stir-baking with sand is ground into powder after steep shortcake; Pericarpium Zanthoxyli is ground into powder after removing fruit stem, impurity; After the Bulbus Allii peeling, mash into mashed garlic; Oleum Sesami is heated to boils, be cooled to 62 ℃ after, put into Herba Portulacae, Unguis Sus domestica and Pericarpium Zanthoxyli that is ground into powder and the Bulbus Allii of mashing into mud; Wherein, the percentage by weight of each component is: Herba Portulacae 9%, Unguis Sus domestica 8%, Pericarpium Zanthoxyli 12%, Bulbus Allii 4%, Oleum Sesami 66%; Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii mixed stirring in Oleum Sesami, airtight dipping, stir macerate once preceding 9 day every day; Flood sucking filtration after 10 days, get the clear liquor packing and promptly get.
Claims (3)
1. a preparation that is used to repair skin mucosa is characterized in that, is to get by following method preparation: Herba Portulacae, Unguis Sus domestica, Zanthoxyli Bungeani powder are broken into powder; After Bulbus Allii is mashed into mud, put into Oleum Sesami, the percentage by weight of each component is: Herba Portulacae 6～12%, Unguis Sus domestica 4～12%, Pericarpium Zanthoxyli 3～12%, Bulbus Allii 4～12%; Surplus Oleum Sesami; Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii mixed stirring in Oleum Sesami, airtight dipping back sucking filtration is got clear liquor and is promptly got.
2. according to the said preparation that is used to repair skin mucosa of claim 1; It is characterized in that: before Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli, Bulbus Allii are put into Oleum Sesami; Earlier Oleum Sesami is heated to and boils, put into Herba Portulacae, Unguis Sus domestica, Pericarpium Zanthoxyli and Bulbus Allii again after being cooled to 55～70 ℃.
3. according to claim 1 or the 2 said preparations that are used to repair skin mucosa, it is characterized in that: airtight dip time is 7～14 days, and stir macerate once preceding 6～13 day every day.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110075494A CN102133326B (en) | 2011-03-28 | 2011-03-28 | Preparation for repairing skin mucosa |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110075494A CN102133326B (en) | 2011-03-28 | 2011-03-28 | Preparation for repairing skin mucosa |
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| CN102133326B true CN102133326B (en) | 2012-09-12 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088800A (en) * | 1993-01-02 | 1994-07-06 | 鞍山钢铁公司 | A kind of skin for the treatment of scalds Traditional Chinese Medicine for external application cream of burn and preparation method thereof |
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2011
- 2011-03-28 CN CN201110075494A patent/CN102133326B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088800A (en) * | 1993-01-02 | 1994-07-06 | 鞍山钢铁公司 | A kind of skin for the treatment of scalds Traditional Chinese Medicine for external application cream of burn and preparation method thereof |
Non-Patent Citations (5)
| Title |
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| 宋祥玖等.皮溃灵治疗皮肤溃疡320例.《中国药业》.2004,第12卷(第01期),74. |
| 扈晓成，等.马齿苋善治皮肤病.《中医杂志》.2005,第46卷(第7期),495-496. * |
| 王福才等.皮溃灵治疗皮肤溃疡的临床与实验研究.《中国中医急症》.2007,第16卷(第05期),548、567. |
| 皮溃灵治疗皮肤溃疡320例;宋祥玖等;《中国药业》;20040125;第12卷(第01期);74 * |
| 皮溃灵治疗皮肤溃疡的临床与实验研究;王福才等;《中国中医急症》;20070515;第16卷(第05期);548、567 * |
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