CN113648382A

CN113648382A - Quick-acting composition for treating burns, scalds and infection and preparation method thereof

Info

Publication number: CN113648382A
Application number: CN202111110414.6A
Authority: CN
Inventors: 杨华
Original assignee: Yibin Guantian Biotechnology Co ltd
Current assignee: Yibin Guantian Biotechnology Co ltd
Priority date: 2021-09-18
Filing date: 2021-09-18
Publication date: 2021-11-16

Abstract

The invention discloses a composition for quickly treating burns, scalds and infection and a preparation method thereof, the composition comprises 20-50 parts of rhizoma picrorhizae, 20-50 parts of lotus rhizome node, 20-50 parts of gypsum, 10-30 parts of semen stemonae, 10-30 parts of mint leaf, 10-30 parts of dragon's blood, 10-30 parts of cinnabar, 10-30 parts of keel, 10-30 parts of oyster, 10-30 parts of cacumen biotae, 10-30 parts of edestan, 10-30 parts of fructus kochiae, 35-70 parts of pseudo-ginseng, 10-30 parts of furazolidone, 10-20 parts of levomycin, vitamin B₂10-30 parts. The pharmaceutical composition has the effects of treating infection or pus discharge, removing necrotic tissue, promoting granulation, preventing hemorrhoid and bedsore from spreading and rotting, quickly taking effect after burns and scalds and quickly rising muscles, is convenient to use, has quick curative effect and good effect, and has good development prospect.

Description

Quick-acting composition for treating burns, scalds and infection and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a quick-acting composition for treating burns, scalds and infections and a preparation method thereof.

Background

Burn and scald mainly refers to the damage of skin, mucous membrane and even deep tissues caused by heat, chemical substances, electric energy, radioactive rays and the like, and is one of common accidental injuries in daily life. After burn and scald, the destruction of the outer layer of the skin can cause the expansion of capillary vessels and the increase of tissue permeability, thereby generating corresponding symptoms such as inflammatory reaction, red swelling and hot pain and the like. Acute inflammatory reaction occurs in a short time of severe burn, which causes a large amount of inflammatory mediators, such as cytokines, to be synthesized and released into tissues in a large amount, so that the tissues and organs are damaged. In addition, injury to endothelial cells and increased tissue permeability following burns can allow large amounts of plasma to enter the interstitial space of the tissue, causing edema. If the burn and scald wound is not treated in time, the probability of external microbes invading the body can be enhanced, namely stronger immune response is initiated, so that the wound is further infected, suppurated and festered. Due to the lack of knowledge on prevention of sudden burns and scalds and emergency treatment after burns and scalds in daily life, the incidence rate of burns and scalds tends to increase year by year, the old and children are generally high-risk people with burns and scalds, the annual incidence rate of the burns and scalds in China is about 1.5% -2%, namely about 2000 tens of thousands of people suffer from burns and burns with different degrees every year, and serious burn and scald patients are easy to cause infection, suppuration and fester of wounds and leave permanent scars if the patients are not treated or treated improperly in time, and even more, the lives of the serious burn and scald patients are endangered.

At present, the medicines for treating burns and scalds are various and can be basically divided into traditional Chinese medicines and western medicines. The treatment means in the western medical field mainly aims at sterilization and inflammation diminishing, mostly adopts antibiotics and sulfanilamide preparations, and needs long-time application of antibiotics and local dressing change treatment. Many treatments are directed to wound healing by damaging the somatic cells surrounding the bacteria, controlling bacterial growth, and creating a long-lasting non-healing condition when the wound is located in a moving joint, or when the healing capacity of the patient is poor, the nutrient supply is poor, and the local microcirculation is impaired. And antibiotic drugs have no nutritional effect, can not improve local microcirculation, and can kill bacteria and damage surrounding healthy cells at the same time, so the treatment effect on special skin injury or ulceration is poor, and most western medicines have the defects of certain toxic and side effects, poor regeneration capability on skin tissues of deep burn wounds, unsatisfactory anti-infection and edema after burn treatment, and high price.

Many Chinese herbal medicines for removing necrotic tissue and promoting granulation also have decrustation effects to different degrees, such as Dongfang I, Yuchu Ten, burn ointment and the like, which all use gypsum, calamine, minium, calcite, halloysite, cuttle bone, nacre, keel, lithargite, amber and other inorganic salts as abundance medicines, and the application of the medicines can cause the decrustation to fall off about 10 days, which is faster than the natural decrustation, but the deep wound surface also needs skin grafting. The modern medical community also adopts other externally applied medicines to promote muscle growth and epidermal healing, such as myogenic yuhong ointment, adhesive plaster and the like, but the adaptability of the medicines and western anti-inflammatory antibiotics is poor, and sepsis still exists in the surface healing easily, so that the wound can not be healed for a long time or is broken in good time. The commonly used traditional Chinese medicine burn and scald ointment also comprises Jingwanhong, scald and fire wound infiltration ointment, Meibao and the like, the representative medicine is Meibao, the curative effect is obvious, but secretion of a wound surface needs to be scraped for many times when the ointment is used, so that a patient is painfully painful, and the infection chance is increased; the ointment of the Baiduobang and the like is only an external antibacterial drug mainly used for diminishing inflammation, and has not ideal treatment effect on burns and scalds.

In addition, the chinese patent application No. 201110249919.0 discloses a burn and scald liquid, a burn and scald ointment and a preparation method thereof, wherein the burn and scald liquid is prepared by sun-drying and powdering giant knotweed, lithospermum, raw gardenia, raw phellodendron and other medicinal materials, soaking the medicinal materials in ethanol for one or two months, filtering the medicinal materials when in use, and adding a small amount of musk. However, the preparation of the burn and scald liquid needs a long time, the using method is not convenient enough, and the ethanol has great irritation to the injured skin, which brings great pain to patients. The burn and scald ointment is prepared by pulverizing lithospermum, angelica dahurica, angelica sinensis, liquorice, rheum officinale, phellodendron and other medicinal materials into powder, taking sesame oil as a matrix, and storing a finished product in a refrigerated manner, wherein a small amount of musk is still added in the use process, so that the use method is still inconvenient.

Chinese patent CN108114090B discloses a Chinese medicinal composition for treating hemorrhoids, burns and scalds, which comprises of rehmannia root, dyers woad leaf, wenshan notoginseng, phellodendron bark, gallnut and tea seed oil, and the preparation method comprises the following steps: pulverizing radix rehmanniae , folium Isatidis, radix Wenyanshan Notoginseng, cortex Phellodendri, and Galla chinensis, sieving, adding tea seed oil, sealing, soaking for 20 days, filtering, collecting supernatant, and sterilizing. However, the patent has low cure rate and long preparation time for patients with hemorrhoids, burns and scalds.

Chinese patent CN101822718A discloses a burn and scald powder, which mainly comprises mother-of-pearl, turtle shell, Stephania delavayi Diels, Wuxincao, radix codonopsitis and sesame oil, and the preparation method comprises the following steps: the raw materials are cleaned, polished, roasted, baked and then crushed to prepare the Chinese patent medicine powder, but the patent does not verify the curative effect of the Chinese patent medicine powder.

Disclosure of Invention

The invention aims to solve the technical problem of providing a composition for quickly treating burns, scalds and infection and a preparation method thereof.

When searching for a medicine capable of quickly treating burns, scalds and infection, the inventor dries traditional Chinese medicines such as astragalus membranaceus, gypsum, borneol, coptis chinensis, hosta plantaginea flower root and golden needle flower root, then mixes the dried traditional Chinese medicines with western medicine furazolidone to prepare powder, and mixes the powder with water according to the mass ratio of 1:500 to treat a burn and scald patient, but the effect is not obvious, and the wound can only reach 30% convergence after two days of treatment; the inventors later tested a series of formulations: wherein the composition comprises (1) Notoginseng radix, Gypsum Fibrosum, Borneolum Syntheticum, rhizoma picrorhizae, flos Hostae Plantagineae root, radix Flammulinae, and furazolidone; (2) notoginseng, nodus Nelumbinis Rhizomatis and StoneOintment, borneol, rhizoma picrorhizae, mint leaf, dragon's blood, cinnabar, furazolidone and penicillins tablet; (3) notoginseng radix, nodus Nelumbinis Rhizomatis, Gypsum Fibrosum, Borneolum Syntheticum, Camphora, rhizoma picrorhizae, folium Menthae, sanguis Draxonis, Cinnabaris, furazolidone, and QINGLEVOXIN; (4) notoginseng, lotus root node, gypsum and vitamin B₂Baibu, agilawood, borneol, camphor, rhizoma picrorhizae, mint leaf, dragon's blood, cinnabar, furazolidone and green levomycin; (5) notoginseng, lotus root node, gypsum and vitamin B₂Baijian, agilawood, borneol, camphor, figwortflower picrorhiza rhizome, mint leaf, dragon's blood, cinnabar, edestan, furazolidone and green levomycin; and the like, and the use amounts of the components in the formula are continuously adjusted and tested, so that the effect is not good, and the test proves that when the formula is used for treating burn and scald or infected patients with wounds of 8-15 cm multiplied by 4-8 cm, the wounds after 2 days of treatment can only achieve 30-70% of local convergence.

Therefore, the inventor continuously selects and adjusts the components and the dosage, and finally finds that the traditional Chinese medicines of rhizoma picrorhizae, lotus rhizome node, gypsum, radix stephaniae tetrandrae, mint leaf, dragon's blood, cinnabar, keel, oyster, cacumen biotae, edestan, fructus kochiae, pseudo-ginseng, agilawood, cimicifugae foetidae, fritillaria, borneol, camphor, cyperus rotundus, western medicines of furazolidone, levomycin and vitamin B are utilized₂The formula is obtained according to the principle of 'monarch, minister, assistant and guide' in the traditional Chinese medicine formula, and the traditional Chinese medicine formula is matched with a certain dosage to play a synergistic effect, and has a special effect on treating burn, scald, infection, hemorrhoid, bedsore and other sore surfaces.

Therefore, in order to solve the above technical problems, the present invention adopts the following technical solutions:

the composition comprises the following components in parts by weight: 20-50 parts of rhizoma picrorhizae, 20-50 parts of lotus rhizome node, 20-50 parts of gypsum, 10-30 parts of semen stemonae, 10-30 parts of mint leaf, 10-30 parts of dragon's blood, 10-30 parts of cinnabar, 10-30 parts of dragon's bone, 10-30 parts of oyster, 10-30 parts of cacumen biotae, 10-30 parts of edestan, 10-30 parts of fructus kochiae, 35-70 parts of pseudo-ginseng, 10-30 parts of furazolidone, 10-20 parts of levomycin, vitamin B₂10-30 parts.

Further onThe composition comprises the following components in parts by weight: 20-40 parts of rhizoma picrorhizae, 20-40 parts of lotus rhizome node, 20-40 parts of gypsum, 15-25 parts of semen stemonae, 15-25 parts of mint leaf, 15-25 parts of dragon's blood, 15-25 parts of cinnabar, 15-25 parts of keel, 15-25 parts of oyster, 15-25 parts of cacumen biotae, 15-25 parts of edestan, 15-25 parts of fructus kochiae, 40-60 parts of pseudo-ginseng, 15-25 parts of furazolidone, 12-17 parts of levomycin, vitamin B₂15-25 parts;

further, the composition comprises the following components in parts by weight: 30 parts of rhizoma picrorhizae, 30 parts of lotus rhizome node, 20 parts of gypsum, 20 parts of semen stemonae, 20 parts of mint leaf, 20 parts of dragon's blood, 20 parts of cinnabar, 20 parts of dragon's bone, 20 parts of oyster, 20 parts of cacumen biotae, 20 parts of fructus cannabis, 20 parts of fructus kochiae, 50 parts of pseudo-ginseng, 20 parts of furazolidone, 15 parts of levomycin, vitamin B₂And 20 parts.

Further, the composition also comprises 8-20 parts of agilawood, 8-20 parts of cimicifuga foetida and 8-20 parts of fritillaria;

further, 10-20 parts of agilawood, 10-20 parts of cimicifuga foetida and 10-20 parts of fritillaria cirrhosa;

further, the traditional Chinese medicine comprises 15 parts of agilawood, 15 parts of cimicifuga foetida and 15 parts of fritillaria.

Further, the composition also comprises 1-8 parts of borneol, 1-8 parts of camphor and 5-15 parts of cyperus rotundus;

further, the medicine comprises 2-6 parts of borneol, 2-6 parts of camphor and 5-10 parts of cyperus rotundus;

further comprises 5 parts of borneol, 5 parts of camphor and 10 parts of cyperus rotundus.

The traditional Chinese medicine always explains "the method comes out from the law", "the method is established according to the syndrome", "the method is the method", and "the medicine has the special characteristics and the combined wonderful use". Therefore, the formula principle is that the medicines are compatible according to the rule of monarch (main), minister (auxiliary), adjuvant and guide, the formula of the traditional Chinese medicine composition is preferably selected and determined, and the purposes of strict compatibility, assistance, treatment and basis seeking are achieved, and both symptoms and root causes are achieved. The method comprises the following specific steps:

rhizoma picrorhizae, nodus Nelumbinis Rhizomatis, Notoginseng radix, furazolidone, and vitamin B₂Is the principal drug and is the core part of the prescription, gypsum, radix stemonae, mint leaf, dragon's blood, cinnabar and keelOyster, cacumen biotae, edestan, levomycin, fructus kochiae as ministerial drugs and assistant monarch drugs for reinforcing treatment, agilawood, rhizoma cimicifugae and fritillaria as adjuvant drugs, the monarch drugs and the ministerial drugs are matched for reinforcing treatment, borneol, camphor and cyperus rotundus as conductant drugs for coordinating the interaction of the drugs, and the efficacy matching of all the components generates synergistic action, so that the symptoms of burn, scald, pyocutaneous disease and the like can be effectively treated.

The pharmaceutical mechanism of the components in the formula of the invention is as follows:

rhizoma picrorhizae: clearing heat and cooling blood: has effects in clearing away heat and cooling blood;

lotus root node: cooling and stopping bleeding: the Chinese medicinal composition can remove vexation and dryness heat, effectively stop bleeding and cool blood, shorten bleeding time, has the characteristics of stopping bleeding and not stasis, and has the effect of relieving bleeding symptoms of multiple parts of a body;

gypsum: clearing heat and purging fire, relieving restlessness and quenching thirst, astringing and promoting granulation;

agilawood: promoting qi circulation, relieving pain, tranquilizing mind, and promoting muscle growth;

cimicifugae foetidae: yang-invigorating, exterior-releasing, eruption-promoting and detoxification;

hundred steps: antibacterial, antiinflammatory, antitussive, expectorant, parasite killing, and antipruritic;

mint leaf: dispelling wind and heat, removing toxic substance, promoting eruption, and refreshing mind;

dragon's blood: stopping bleeding, relieving pain, promoting blood circulation, removing blood stasis, promoting granulation, and healing wound;

cinnabar: has slightly cold nature and sweet taste, enters heart meridian, and has effects of clearing heat and detoxicating, relieving palpitation and tranquilization;

fritillary bulb: detumescence, nodulation and incrustation;

keel: has effects of tranquilizing mind, eliminating dampness, promoting wound healing, and eliminating dampness;

oyster shell: liver-calming and wind-calming herbs; yin-nourishing herbs; can prevent cardiovascular diseases and protect vascular endothelium;

cacumen biotae: cooling blood to stop bleeding;

and (3) hemp seed: moistening sore, avoiding sweet and dry;

the preparation method comprises the following steps of (1) preparing broom cypress fruit: removing dampness, relieving itching, and treating skin eczema, and skin pruritus;

cyperus rotundus: promoting circulation of qi and blood;

pseudo-ginseng: promoting blood circulation, stopping bleeding, relieving pain, and promoting muscle growth;

borneol: relieving pain, preventing putrefaction, inhibiting bacteria, clearing away heat, and promoting granulation;

camphor: opening orifices, strengthening heart, killing parasites and relieving itching;

western medicine furazolidone: diminishing inflammation;

levo-mycin: diminishing inflammation and drawing out poison;

vitamin B₂: for local promotion of development and cell regeneration; participating in the growth metabolism of cells; it can be used in combination with other substances to participate in various metabolism, promote growth and development, and maintain the integrity of skin and cell membrane.

The invention provides an application of the composition in preparing products for treating one or more symptoms of burn, scald, infection and pyocutaneous disease.

Further, the sore is selected from one of hemorrhoids and bedsores.

Further, the product is an external preparation.

Further, the external preparation includes, but is not limited to, sprays, lotions, paints, liniments, emplastrums, ointments.

The invention also provides a preparation method of the composition, which comprises the following steps: the raw materials are prepared into powder and added with water for standby.

Further, the raw material medicine comprises: the mass ratio of water is 1-5: 500.

the medicine is obtained through the research of the treatment experience of an inventor among twenty years, and after a plurality of municipal and county-level hospitals treat patients with serious fruitless new wounds, infection, sore, scald and burn, the medicine powder prepared by mixing the medicine powder with water is applied to the wounds after being soaked for one hour, the medicine powder is applied, the wounds can be healed within 20 days seriously, the symptoms can be healed within one week, sequela is not left, transfusion, medicine taking and injection are not needed in the midway of treatment, and no scar is left after healing.

The invention has the following beneficial effects:

(1) the composition of the invention accords with the compatibility principle of 'monarch, minister, assistant and guide', the medicines are combined together, the tissue regeneration and the meat supplement can be realized, clinical tests prove that the pharmaceutical composition is prepared by compounding a plurality of traditional Chinese medicine components and western medicines, each medicine has synergistic effect, is safe and free of side effect, has the effects of rapidly diminishing swelling, removing necrotic tissue and promoting granulation and resisting infection, has the effective cure rate of 100 percent on burn, hemorrhoid, bedsore and skin ulceration caused by infection, does not relapse after healing, has no toxic or side effect, has no sequela, short course of treatment and quick response, can greatly relieve the pain of patients, and has obvious curative effect.

(2) The invention has simple preparation method, convenient use of the medicine, short treatment course and low cost, can be applied by patients, reduces the economic and mental burdens of the patients and has good development prospect.

Drawings

Fig. 1 is a graph of the course of treatment for the patient of case 9.

In FIG. 1, day 1 treatment; treatment on day 2; treatment on day 3; day 4 treatment; day 5 treatment; day 6 treatment; day 7 treatment; day 8 treatment.

Detailed Description

The present invention is further illustrated by the following examples and specific tests. The following examples are only preferred embodiments of the present invention and are not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Example 1 preparation of the composition

30 g of rhizoma picrorhizae, 30 g of nodus nelumbinis, 20 g of gypsum, 50 g of pseudo-ginseng, 20 g of furazolidone and vitamin B₂20 g, 20 g of Baibu, 20 g of mint leaf, 20 g of dragon's blood, 20 g of cinnabar, 20 g of edestan, 20 g of belvedere fruit, 20 g of fritillaria, 15 g of dragon's bone, 15 g of cacumen biotae, 15 g of oyster, 10 g of cimicifugae foetidae, 10 g of cyperus rotundus, 10 g of levomycin, 5 g of agilawood, 5 g of camphor and 5 g of borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

The use method and the effect are as follows:

treatment of infected or purulent wounds: mixing 5 g of the powder with 500g of water, and keeping for 120 days. The affected part is scrubbed with 5% of the medicinal liquid in the medicine bottle each time, and the medicine powder is coated around the affected part and is replaced and washed once a day, so that the medicine has the effects of removing necrotic tissue and promoting granulation.

And (3) treating hemorrhoids: 5 g of the medicinal powder is mixed with 500g of water for standby, and the shelf life is 120 days. The absorbent cotton is wetted with the medicinal liquid and then applied to the anus, and the absorbent cotton and the medicinal liquid are replaced once a day.

Treatment of severely infected patients: the medicine powder is applied to the wound, infected or scalded, the wound is completely spread on the wound, particularly serious, the wet medicine powder on the wound is washed off after one hour, then the medicine powder is applied, the wound is healed after 6 hours, the wound is washed and replaced once a day, the serious wound is healed within 10 days, and the wound can be healed within 20 days.

And (3) treating other sore diseases: the medicinal cotton is wetted by the medicinal liquid and is pasted around the wound when the initial red swelling of the sore is not mature, the medicinal cotton is wetted by the medicinal liquid and is pasted on the affected part after the medicinal cotton is dried, and the mild patient can be cured in 3 days and the severe patient can be cured in 6 days. If the head of a patient is going to be sore, the periphery of the head sore is protected by the absorbent cotton patch, the sore can be pus-drained within about 20 hours, the patch is continuously protected by the method, and the medicinal powder can be applied to the pus-drained sore opening for 6 hours to heal after the red and swollen skin color of the affected part becomes the normal skin color.

Contraindications of drugs: it is not suitable for chilblain patients and pregnant women.

Example 2 preparation of the composition

35 g of rhizoma picrorhizae, 35 g of nodus nelumbinis, 30 g of gypsum, 55 g of pseudo-ginseng, 25 g of furazolidone and vitamin B₂25 g, 25 g of semen stemonae, 25 g of mint leaf, 25 g of dragon's blood, 25 g of cinnabar, 25 g of edestan, 25 g of fructus kochiae, 25 g of fritillaria, 20 g of dragon's bone, 20 g of cacumen biotae, 20 g of oyster, 15 g of cimicifugae foetidae, 15 g of cyperus rotundus, 15 g of levomycin, 10 g of agilawood, 10 g of camphor and 10 g of borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

Example 3 preparation of the composition

50 g of picrorhiza rhizome and lotus root50 g of Jiejie, 50 g of gypsum, 70 g of pseudo-ginseng, 30 g of furazolidone and vitamin B₂30 g, 30 g of Baibu, 30 g of mint leaf, 30 g of dragon's blood, 30 g of cinnabar, 30 g of edestan, 30 g of belvedere fruit, 20 g of fritillaria, 30 g of dragon's bone, 30 g of cacumen biotae, 30 g of oyster, 20 g of cimicifugae foetidae, 15 g of cyperus rotundus, 20 g of levomycin, 20 g of agilawood, 8 g of camphor and 8 g of borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

Example 4 preparation of the composition

20 g of rhizoma picrorhizae, 20 g of nodus nelumbinis, 20 g of gypsum, 35 g of pseudo-ginseng, 10 g of furazolidone and vitamin B₂10 g, 10 g Baibu, 10 g mint leaf, 10 g dragon's blood, 10 g cinnabar, 10 g edestan, 10 g belvedere fruit, 10 g fritillaria, 10 g dragon's bone, 10 g cacumen biotae, 10 g oyster, 10 g cimicifuga foetida, 5 g cyperus rotundus, 10 g levomycin, 8 g agilawood, 8 g camphor and 1g borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

Example 5 preparation of the composition

Rhizoma picrorhizae 40 g, nodus Nelumbinis Rhizomatis 40 g, Gypsum Fibrosum 35 g, Notoginseng radix 60 g, furazolidone 25 g, vitamin B₂25 g, 25 g of semen stemonae, 25 g of mint leaf, 25 g of dragon's blood, 25 g of cinnabar, 25 g of edestan, 25 g of fructus kochiae, 15 g of fritillaria, 25 g of dragon's bone, 25 g of cacumen biotae, 25 g of oyster, 20 g of cimicifugae foetidae, 10 g of cyperus rotundus, 17 g of levomycin, 20 g of agilawood, 6 g of camphor and 6 g of borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

Example 6 preparation of the composition

35 g of rhizoma picrorhizae, 35 g of nodus nelumbinis, 25 g of gypsum, 45 g of pseudo-ginseng, 15 g of furazolidone and vitamin B₂15 g, 20 g of Baibu, 20 g of mint leaf, 20 g of dragon's blood, 20 g of cinnabar, 15 g of edestan, 15 g of belvedere fruit, 20 g of fritillaria, 30 g of dragon's bone, 30 g of cacumen biotae, 30 g of oyster, 15 g of cimicifugae foetidae, 10 g of cyperus rotundus, 15 g of levomycin, 10 g of agilawood, 2 g of camphor and 6 g of borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

Example 7 preparation of the composition

30 g of rhizoma picrorhizae, 35 g of nodus nelumbinis, 25 g of gypsum, 50 g of pseudo-ginseng, 15 g of furazolidone and vitamin B₂20 g, 25 g of Baibu, 25 g of mint leaf, 20 g of dragon's blood, 20 g of cinnabar, 20 g of edestan, 15 g of belvedere fruit, 15 g of fritillaria, 30 g of dragon's bone, 30 g of cacumen biotae, 30 g of oyster, 20 g of cimicifugae foetidae, 10 g of cyperus rotundus, 15 g of levomycin, 10 g of agilawood, 3 g of camphor and 5 g of borneol. Drying the traditional Chinese medicines in the raw materials, and then preparing the dried traditional Chinese medicines and western medicines into powder for later use.

Test examples

Clinical research

Clinical verification and clinical test data statistics of years show that after the composition is used for treatment, the cure rate of patients suffering from burns, scalds, sores, infection, hemorrhoids, bamboo and wood injuries, iron nail sniping and the like reaches 100%, no scar is left, and no sequelae are generated.

The beneficial effects of using the compositions of the present invention are demonstrated in the following specific cases:

the formulations used in the following cases were all prepared from the composition of example 1.

Case 1

When a man goes to work in 2006 at Davidia Davidi Zhentong Community in Davidia county, Yibin, Sichuan province, the man is burnt to the position of the lower leg from the face by flame of a stepping kiln, the burn area is about 60%, the hospital diagnoses the III-level burn, the affected part is completely infected after the local hospital visits the doctor for 2 months, the hospital takes no policy and prepares to transfer the patient to the hospital for skin grafting, but the skin grafting is not carried out after the emergency in the few days at the Yangtze certain family, the medicine powder is mixed into lotion by the formula of the invention in the ratio of 1:50 at the 15 th noon to clean the wound, the medicine powder is applied to the infected part after cleaning, and the medicine returns to the hospital at 19 th night to treat the infected area, the infected area is found to be completely closed and crusted, and doctors in the hospital feel curiosity. The following day after discharge from hospital, the patient was treated with the present invention according to the first treatment regimen. When the medicine is applied on the third day, 20% of scab parts of the infected areas of the patients are already decrusted, and the decrusted parts are already lifted to grow into fresh and tender meat. On the fourth day, the patient had 40% of scab at the scab site and the skin was raised at the scab site. On the fifth day, the patients had 50% of the scab and the muscle was raised. When the medicine is applied on the sixth day, the scab is removed from the infected scab part in the whole area, and the scab is all fresh meat. On the seventh day, the medicinal powder and water are synthesized into medicinal liquid in the proportion of 1:5 by the formula of the invention, and the medicinal liquid is smeared on the fresh and tender meat. The patient is cured when being checked on the eighth day, and no hidden danger or scar is left.

Case 2

The treatment exhaust funnel scalds the patient who needs skin grafting: in 2007 of a male, a thigh is scalded by a motorcycle exhaust funnel, a wound is 30 cm long and 10 cm wide, and the male can treat 2 months in each hospital successively, but the wound is infected in a whole area of 30 cm × 10 cm and pus is discharged, so that 3 wounds of about 5 cm × 5 cm are ulcerated and collapse to about 3 cm deep. The patient is cleaned by the liquid medicine prepared by the formula, after the medicine powder is applied to the infected part, the wound with the size of 5 centimeters multiplied by 5 centimeters is scabbed when the medicine is changed the next day, the scabbed area is 0.5 multiplied by 0.5 centimeter, other infected parts are scabbed, and the patient is cleaned and applied with the medicine by a first method. When the patient is changed on the third day, the wounds on 3 places are scabbed, the scabbed area is 1 multiplied by 1 cm, other infected parts begin to scab, the area of the fresh muscle growing from the edge of the infected part to the central point is about 5 cm long and 0.1 cm wide, and the medicine powder is applied to the infected part after being cleaned by the medicine water. When changing the medicine for the patient on the fourth day, 3 wounds of 5 cm × 5 cm are scabbed, the scabbed area is 1.5 × 1.5 cm, other infected parts are scabbed, the area of the fresh muscle growing from the edge of the infected part to the central point is about 10 cm long and 2 cm wide, and the medicine powder is applied after the medicine is cleaned by the liquid medicine. On the fifth day, when the patient changed the medicine, 3 wounds of 5 cm × 5 cm all scabbed 2 × 2 cm, other infected parts also scabbed, the area of the fresh muscle growing from the edge of the infected part to the central point is about 15 cm long and 2.5 cm wide, and the medicine powder is applied after the patient is cleaned with liquid medicine. On the sixth day, when the patient changed dressings, 3 wounds of 5 cm × 5 cm had scabbed with a scab area of 2.5 × 2.5 cm, and other infected sites had scabbed, and fresh muscles of about 20 cm long and 3 cm wide grew from the edge of the infected site to the central point, and were further cleaned with liquid medicine and then applied with medicinal powder. When changing the medicine for the patient on the seventh day, 3 wounds of 5 cm × 5 cm are scabbed completely, no scab is formed, other infected parts are scabbed, the area of new muscle growing from the edge of the infected part to the central point is about 25 cm long and 4.5 cm wide, and the medicine powder is applied after the new muscle is cleaned by the liquid medicine. When the patient is changed on the eighth day, all the 3 wounds with the size of 5 centimeters and the size of 5 centimeters are scabbed, no scab is removed, other infected parts are scabbed, no scab is removed at the center vertex, new muscle growing from the edge of the infected part to the center point and other infected parts are scabbed, and the medicinal powder is applied after the patient is cleaned by the medicinal water. When the patient changes the medicine on the ninth day, all 35 cm × 5 cm ulcerated wounds scab, no scab is removed, other infected parts are scab, no scab is removed at the center vertex, 25% of scab-removed parts from the edge of the infected part to the center point grow fresh muscles, the growth area is 3 × 3 cm, and the medicinal powder is applied after the patient is cleaned by using the medicinal water. On the tenth day, 3 wounds of 5 cm by 5 cm had all scabbed and the entire infected site had grown new flesh with a red color. On the next tenth day, twelfth day, thirteen day, fourteenth day and fifteenth day, the medicinal powder is mixed into a medicinal liquid according to the proportion of 1:5 every day, and the medicinal liquid is applied to the scab-removed part three times every day, so that the normal flesh is recovered.

Case 3

Treating patients with bamboo stick sniper infection and needing skin preparation: one village Zhongzhi of Jinshan village two society of Davidian county, male, in 2009 when ploughing, the shank is scratched carelessly by bamboo stick, no fruit is treated everywhere, 15 cm long after 3 months, 6 cm wide wound also has red swelling, ulceration and purulence, and the center point of the infected part has vortex with the area of 2 x 2 cm and the depth of 3 cm, almost bone appears, the pain of the patient is hard to endure, and many hospitals must perform skin grafting treatment after examination. Because the patient is difficult to be in the home and cannot bear high cost, the medicament prepared by the formula is used for cleaning the wound infected with suppuration and the central point vortex after a liquid medicament prepared by the formula (the mass ratio of the medicament powder to the water is 1:5), and then the medicinal powder is wrapped by a medical cotton swab. The patient was started the next day with a change of dressing, except for the 15 cm long, 6 cm wide center point where no scab formed and the surrounding wound where scab formed. The patient was also allowed to change on day four, and a 15 cm long by 6 cm wide ulcerated area had also begun to eschar. And when the dressing is changed on the fifth day, the scab is not removed at the scab removing position of the center point, the scab removing position of the wound at the periphery begins, and fresh tender meat grows. When the patient is changed on the sixth day, the scab removal is started at the scab removing position at the center of 15 cm long and 6 cm wide, and new tender meat grows at the scab removing position at the periphery, and the growing area is 13 cm long and 5 cm wide. The patient can walk at the eighth day, and after 15 days of medicine is dispensed to the patient, the patient can change the medicine at home, and the patient can be fed back to recover without using the dispensed medicine. Why do not have 100% confidence in hospital for local infection and tissue regeneration? Since most treatments are carried out by infusion of saline from the inside to the outside, topical treatments do not have good anti-infective and granulation promoting properties.

Case 4

Rapidly treating sore: wu-chi in Davidian Xiaozhu Zhenlimucun 2 group in Davidian county, male, 2008 has a large sore growing on the thigh, about 10 cm long and 10 cm wide, and after one week of infusion and injection in Xiaozhu hospital, the patient still has no improvement, but is more swollen, and the operation is recommended in hospital. The medicinal powder is mixed with water into lotion according to the proportion of 1:5, and the lotion is wetted by medical absorbent cotton and is applied to the whole wound of the sore, and a bandage is tied. The next morning when the patient changes dressings, the bandage is completely loosened, the sore surface is reduced by about 1 multiplied by 1 cm, the medical absorbent cotton is wetted by the medicinal liquid and then is applied to the local part of the sore, the bandage is bound, the dressing change is continued in the afternoon, and the bandage is bound. When the patient changes the dressing on the third day, the bandage almost falls off, the bandage is taken out, the red swelling and the total decline are seen, the color of the bandage is the same as that of the skin of a normal person, the bandage can be walked by walking, and the dressing is not needed subsequently.

Case 5

Treating large infected patients requiring skin grafting: in nine groups of Bihe Tokamuracun, Changning county, Yibin, Sichuan province, patients are Huang Xian Lian, women, first three winter months in lunar calendar in 2012, when water is boiled at home, sudden Meniere syndrome happens, a pot of boiled water is carelessly scalded from chest to large and small legs, the scalded part is from face to small legs, and about 80% of the area is diagnosed as II-level burn. Later, the patient is cured by being sent to a hospital in Changning county urgently and treated by infusion, human albumin injection and electric lamp baking, 80% of the whole area of the wound is scabbed after one month, but internal infection is caused, and the pain of the patient is hard to endure. The hospital requires the patient to transfer to the hospital for skin grafting, and the patient is difficult to transfer just during the spring festival and only goes home to lie in bed. The medicine powder is mixed with water in a ratio of 1:5 after the patient is asked for the treatment condition, and the medicine powder is applied to the whole area after the wound is cleaned. On the following day, 80% of the scald area was scabbed when the patient changed dressings. On the third day, the patient had eschared the whole area of the infected site. And continuously changing the dressing by adopting the dressing changing modes of the previous two times, and changing the dressing of the patient according to the dressing changing methods of the previous two times in the next fourth to eighth days, wherein the scab part begins to be subjected to scab removal and new flesh grows out in the ninth day. As the way is far away and the healing condition of the patient is improved, the medicinal powder and the medicinal liquid prepared by the medicinal powder are given to the family of the patient, the family changes the medicine by himself, and the medicinal liquid is checked after one week, so that 10% of scab parts of the patient are decrusted, and new meat grows. After two weeks, the decrustation area of the scab site of the patient was 20%, and new flesh grew. After three weeks, the area of the scab site was 30% and new flesh also grew. The decrustation area was 40% after four weeks, and new meat grew. After five weeks, the decrustation area was 55% and new meat grew. After six weeks, the decrustation area was 65% and new meat grew. After seven weeks, all scabs were removed, and the flesh was full of new flesh and fresh and tender. The liquid medicine prepared by the formula of the invention is smeared on the decrustation part 6 times a day, the patient is healed after ten days, and the decrustation part is recovered to be normal without scars.

Case 6

Treating patients with hemorrhoids: when internal and external hemorrhoids of a male in 3 months in 2019 are suddenly caused by a Chinese dive spring town of Chinese dive county in Yibin city, Sichuan province, the medicine powder is used for preparing a medicine liquid by using water according to a ratio of 1:5 after a certain hospital has no fruits after medicine taking, injection and transfusion, the medicine liquid is used for wetting medical absorbent cotton and then is filled into the interior and the exterior of a liver, and the medicine is still applied in the same way after the medicine liquid is removed when the medicine liquid is used in a toilet. The medicine is applied in the same way on the second day and the third day, the internal and external hemorrhoids are found to be shrunk every day, and the hemorrhoids are healed after four days.

Case 7

Sniping of iron nails: in 7 months in 7 th of the country, Cao and women, when a house is fixed at home, the house is inadvertently snipped by embroidery nails spindle on a wood board, the nails are all inserted into flesh, and after being pulled out, the blood flow is not continuous, the pain is hard to endure, the depth of the sniping nails into soles is 5 cm, and the soles are expanded by swelling to 10 cm. After the nail is pulled out, the medical cotton is dipped in the liquid medicine prepared by the formula of the invention, and the liquid medicine is stuck on the wound and bundled. When the patient is changed the next day, the iron scraps on the absorbent cotton are sucked out for a plurality of times, the swelling is reduced by 5 cm, the medical absorbent cotton is still wetted by the liquid medicine, and the liquid medicine is applied to the injured part of the patient and is wrapped. When the patient is changed on the third day, the swelling is almost completely eliminated, the pain is reduced by 60%, and the liquid medicine is applied after the patient is continuously cleaned in the same way. The patient says the wound is not painful on the fourth day and does not need to take the medicine.

Case 8

30 g of rhizoma picrorhizae, 30 g of nodus nelumbinis, 20 g of furazolidone and vitamin B₂20 g of gypsum, 30 g of gypsum, 20 g of stephania, 20 g of mint flavor, 20 g of dragon's blood, 20 g of cinnabar, 15 g of dragon's bone, 20 g of oyster, 15 g of cacumen biotae, 10 g of edestan, 150 pieces of levomycin, 10 g of camphor and 5 g of borneol. Drying the traditional Chinese medicines in the raw materials, then preparing the dried traditional Chinese medicines and western medicines into powder, mixing the powder with water according to the mass ratio of 1:500, and preparing the powder into a liniment, a lotion or a liniment.

The wound of the burn and scald patient is 8 cm long and 5 cm wide, and 70% of the local convergence is achieved after 6 hours of treatment.

Case 9

Treating patients scalded by 100-degree soybean milk water: two groups of young adults in the Davidian town of Davidian county of Yibin city, Sichuan province are all together, namely a man, the age of 3 and the year of 2019, make bean curd jelly in a family, and when the soybean milk is placed in a large basin upside down, the young adults are carelessly played beside the young adults and fall into a 100-degree soybean milk basin, so that a II-level scald of 60% of the whole body area is caused, when a patient is treated, the scald part is all soaked in water, the flesh color is red and bright, the scald part is from the back to the lower leg, the area is 40 cm long, and the scald part is 20 cm wide. The medicinal powder of the invention is mixed with water according to the proportion of 1:5 mixing into medicinal liquid, cleaning the scald part, cleaning, cutting off the water bubbles with a sterilizing shear, cleaning again, and applying the medicinal powder on the scald part (figure 1A). When changing the dressing the next day, the wound of 40 cm long and 20 cm wide begins to scab (fig. 1B), and the medicinal liquid is still used for cleaning, and the medicinal powder is applied to the scald after being washed out. On the fourth day, the scab of the scalded part with the length of 40 cm and the width of 20 cm is removed by 15 percent (figure 1C), the cleaning and the dressing change are carried out in the same way, the medicinal powder with the formula is applied to the part without the scab after the cleaning, and the scab part is smeared by the disinfectant liquid of the invention (figure 1D). On the fifth day, the patient changed the medicine, the area of the scab area was 25% (fig. 1E), the patient was cleaned and changed the medicine in the same way, and the medicine powder was applied to the non-scab area after the cleaning, and the scab area was smeared with a disinfectant. On the sixth day, the patient changed the dressing, the area of the scab at the scab-forming site was 35% (fig. 1F), and the same procedure was followed for cleaning and dressing change, and the medicinal powder was applied after the cleaning, and the scab-forming and muscle-raising site was rubbed with a disinfectant. And when changing the medicines on the seventh day, all scabs of scab parts are removed, the new flesh is fresh and tender (figure 1G), and the medicine liquid is used for cleaning 3-5 times every day. And when changing the medicine on the eighth day, the medicine is smeared on the fresh meat 3-5 times per day (figure 1H). The healing period is up to the ninth day.

The pharmaceutical composition is prepared by compounding a plurality of traditional Chinese medicine components and western medicines, follows the formula principle of 'monarch, minister, assistant and guide', has synergistic effect of all the medicines, is safe, does not have side effect, has the effects of quickly diminishing swelling, removing necrotic tissue and promoting granulation and resisting infection, has the effective cure rate of 100 percent on burns, hemorrhoids, bedsore and skin ulceration caused by infection, has no sequelae, takes effect quickly, and has obvious curative effect

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. The composition is characterized by comprising the following components in parts by weight: 20-50 parts of picrorhiza rhizome, 20-50 parts of lotus rhizome node, 20-50 parts of gypsum and stemona root10-30 parts of mint leaf, 10-30 parts of dragon's blood, 10-30 parts of cinnabar, 10-30 parts of keel, 10-30 parts of oyster, 10-30 parts of cacumen biotae, 10-30 parts of edestan, 10-30 parts of fructus kochiae, 35-70 parts of pseudo-ginseng, 10-30 parts of furazolidone, 10-20 parts of levomycin, vitamin B₂10-30 parts.

2. The composition according to claim 1, characterized by comprising the following components in parts by weight: 20-40 parts of rhizoma picrorhizae, 20-40 parts of lotus rhizome node, 20-40 parts of gypsum, 15-25 parts of semen stemonae, 15-25 parts of mint leaf, 15-25 parts of dragon's blood, 15-25 parts of cinnabar, 15-25 parts of keel, 15-25 parts of oyster, 15-25 parts of cacumen biotae, 15-25 parts of edestan, 15-25 parts of fructus kochiae, 40-60 parts of pseudo-ginseng, 15-25 parts of furazolidone, 12-17 parts of levomycin, vitamin B₂15-25 parts;

3. The composition according to claim 1 or 2, further comprising 8-20 parts of agilawood, 8-20 parts of cimicifuga foetida, 8-20 parts of fritillaria;

4. The composition according to claim 1 or 2, further comprising 1 to 8 parts of borneol, 1 to 8 parts of camphor, 5 to 15 parts of cyperus rotundus;

5. Use of a composition according to any one of claims 1 to 4 in the manufacture of a product for the treatment of one or more symptoms of burns, scalds, infections, sores and ulcers.

6. Use according to claim 5, wherein the sore is selected from one of haemorrhoids and bedsores.

7. Use according to claim 5, characterized in that the product is an external preparation.

8. The use according to claim 7, wherein the external preparation is one selected from the group consisting of a spray, a lotion, a liniment, a patch, and an ointment.

9. A process for the preparation of a composition according to any one of claims 1 to 4, characterized in that it comprises the following steps: the raw materials are prepared into powder and added with water for standby.

10. The preparation method according to claim 9, wherein the raw material drug: the mass ratio of water is 1-5: 500.