CN105168361A - Compound plant oil liniment for treating burns and scalds and preparation method of compound plant oil liniment - Google Patents
Compound plant oil liniment for treating burns and scalds and preparation method of compound plant oil liniment Download PDFInfo
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Abstract
The invention relates to a plant oil type compound biological medicine composition for treating burns and scalds and a preparation method of the plant oil type compound biological medicine composition and belongs to externally applied agents. The compound biological medicine composition is prepared from major ingredients including clove oil, lavender essential oil, tea tree oil, argy wormwood leaf oil, star anise oil and cassia oil as well as the balance medically acceptable solvents or minor ingredients. The compound biological medicine composition has the advantages that the compound biological medicine composition has definite treatment effect for local burns and scalds, can alleviate symptoms of dermatoses such as psoriasis, dermatitis and eczema, is capable of promoting cell regeneration, speeding up wound healing, removing scars, burns and sunburns effectively and has the pharmacological activity such as antiviral action, bactericidal action, pain relief and anti-inflammatory action.
Description
Technical field
The invention provides a kind of vegetable oil compound recipe compound liniment for the treatment of burn and scald, additionally provide its preparation method simultaneously, specifically a kind of burn and scald for the treatment of.
Background technology
Burn is important wound common in daily life, generally mean because heating power is as the liquid (water that boils, oil, soup), red-hot metal, flame, steam and the infringement of the body surface organization caused by high-temperature gas, the mainly destruction of human body skin barrier, severe patient can injure subcutaneous tissue, muscle, skeleton, joint, neural, blood vessel, even internal organs, also the position that mucosa is coating can be injured, 5000-10000 people is about had to burn in every 1,000,000 people every year, burn is not only the damage of local organization, and reaction or the damage of general can be caused to a certain extent, especially large-area burns, the each system of whole body, organize and all can be involved.
As one accident and disastrous accident, burn not only occurs in a large number in war, also very common at ordinary times.The most startling as Jilin commercial mansion fire in 2011, the mall big fire of Rider, Tianjin in 2012, department store, Weifang, Shandong in 2013 fire etc., all cause huge property and personnel's injury and military impact all larger, after World War II, national governments and medical circle to widely pay attention to.
Domestic market has the medicine of much treating burn, scalding, these Drug therapy speed are slow, expensive, very large financial burden is caused to injured medication person, and although the medicine had allows wound healing, but there is cicatrix to reserve after treatment, bring huge misery and negative effect in spirit to patient.
The folk prescription quintessence oil used, composition is simple, effect is single, treatment speed is slow, desirable result of use can not be reached, be difficult to carry out marketing application, China Patent No. a kind of compound essential Oil for the treatment of skin burn, scald that has been the disclosure of the invention of CN101199772A, it is made according to certain ratio primarily of Olibanum quintessence oil, Flos Chrysanthemi Indici quintessence oil, orange peel oil, aloe essential oil, chamomile essential oil, tea tree ethereal oil, Semen Tritici aestivi germ oil.This technical scheme has effect of removing toxic substances pain relieving, anti-inflammation, moisturizing, but does not have and improve skin properties, promote cell regeneration, accelerating wound healing, calm down the effect of cicatrix.China Patent No. a kind of compound essential Oil improving skin properties that has been the disclosure of the invention of CN102397182A, it is primarily of Flos Rosae Rugosae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, Cananga odorata quintessence oil, tea tree ethereal oil, Geranium Essential, Olibanum quintessence oil, aloe essential oil is mixed according to certain ratio, it is dark and gloomy that the present invention can effectively improve skin color and luster, absorbability is poor, dry, poor flexibility, easily wrinkling, fat secretion waits skin problem, to scar of dispelling, antibacterial pain relieving, alleviate psoriasis, the skin problem DeGrains such as eczema, total effective rate only reaches about 80%, the present invention can not only improve cutaneous pigmentation, coarse low and deep, also be applicable to the various epidermis benign neoplasms caused by human papillomavirus, as verruca plana, verruca filiformis, verruca vulgaris etc.
Summary of the invention
The invention provides a kind of vegetable oil compound liniment for the treatment of burn and scald and preparation method thereof, to local burn and scald, there is clear and definite therapeutical effect, also can alleviate the dermopathic symptoms such as psoriasis, dermatitis and eczema, to promotion cell regeneration, accelerating wound healing, calm down cicatrix, bright sunburn all effectively, also there is the pharmacologically actives such as antiviral, sterilization, pain stop and anti-inflammation simultaneously.For better treating empyrosis, provide a kind of bio-pharmaceutical preparation of natural botanical source.
A kind of vegetable oil compound liniment for the treatment of burn and scald of the present invention, it is characterized in that being prepared from by following raw material proportioning:
Oleum Caryophylli 2-15, Herba Lysimachiae foenum-graeci quintessence oil 15-30, tea tree ethereal oil 15-25, Oleum Folium Artemisiae Argyi 0.8-2, Oleum Anisi Stellati 0.2-2, Oleum Cinnamomi 0.5-2, liquid paraffin 80-120, Mentholum 20-45.
A kind of vegetable oil compound liniment for the treatment of burn and scald of the present invention is prepared from by the raw material of following optimum weight part proportioning:
Oleum Caryophylli 5, Herba Lysimachiae foenum-graeci quintessence oil 25, tea tree ethereal oil 20, Oleum Folium Artemisiae Argyi 2, Oleum Anisi Stellati 2, Oleum Cinnamomi 1, liquid paraffin 120, Mentholum 25.
A kind of preparation method for the treatment of the vegetable oil compound liniment of burn and scald of the present invention, comprises the following steps:
Take said medicine in proportion, first Mentholum and liquid paraffin are dissolved in water-bath, add Oleum Cinnamomi immediately, Oleum Caryophylli is placed on magnetic stirring apparatus and stirs, then add remaining quintessence oil in proportion successively to continue to stir, whipping temp is 20-50 DEG C, and mixing speed is 30-60 rev/min, and mixing time is 1-5 hour, until clear, obtain product.
A kind of preparation method for the treatment of the vegetable oil compound liniment of burn and scald of the present invention, it is characterized in that preferred whipping temp is 25 DEG C, mixing speed is 30 revs/min, mixing time 2h.
A kind of vegetable oil compound liniment for the treatment of burn and scald of the present invention, it is characterized in that, said composition adds other adjuvant such as solubilizing agent or nonaqueous solvent and can be made into gel, ointment, spray, lotion, suppository etc. for the disinfectant of skin and mucosa, pasteurization towelette, antiseptic gauze, the various sterile products such as adhesive bandage, can also the multi-form or object such as health and daily chemical products use.
in medicine used in the present invention,oleum Caryophylli: resisting pathogenic microbes (antifungal and antibacterial), suppress PR8 strain virus, warming the stomach is aromatic stomachic, can abdominal bloating be alleviated, strengthen digestion power, alleviate nausea and vomiting, the kidney warming, relieving asthma, go halitosis, effectively alleviate toothache (non-inflammation toothache) and anthelmintic action.Tea tree oil: have very strong antivirus action, can promote wound healing, treatment skin trauma, burn; Existing market sell personal care articles as in hair nursing, body care, foot lotion, soap, antibiotic property foot lotion, flavorants and oral care product, all containing tea tree oil as principal agent active component.Herba Lysimachiae foenum-graeci quintessence oil: effectively can improve scald, sunburn, eczema, chronic eczema, the skin of abscess, improves cicatrix, bacteria growing inhibiting, help natural on-off cycles of hair growth modern medicine study to show that lavandula angustifolia can also promote cell regeneration, Bergamot Mint Extract, improve insomnia, reduce hypertension, calm heart, gynecological and digestive problems, parasite killing, to purify air, but also purification of the mind, mood placating, alleviate indignation, centre of equilibrium is neural, problem such as conditioning gynecological and digestive system etc.Oleum Folium Artemisiae Argyi: there is antibacterial, antiviral, antiallergic, anticoagulation, enhancing immunologic function, hepatoprotective function of gallbladder promoting, antipyretic calmness, also there is certain eliminating the phlegm, antitussive effect.Oleum Anisi Stellati: have antibacterial (gram positive bacteria: staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, gram negative bacteria: escherichia coli, bacillus subtilis, vibrio cholera and Bacillus typhi, Salmonella paratyphi, dysentery bacterium), antioxidation, analgesia, insecticidal action, modern medicine study shows that Oleum Anisi Stellati also has leukocyte increasing and antihistamine effect, can be used as fragrant remedium corrigens and stomachic.Oleum Cinnamomi: be spice, has fragrant stomach invigorating, the effects such as wind dispelling.Can be used for dispelling the wind and dampness pathogens and skin pruritus, same to Oleum Cinnamomi.The compound liniment made after said components being mixed, its effective ingredient is concentrated to produce synergism, compensate for the defect of one-component weak curative effect, and antiviral effect is remarkable.
the present invention has following beneficial effect: the present inventionafter medicine is applied to skin surface, forms one deck uniform medicine film and can prevent the moisture of skin surface from evaporating and the oozing out of tissue fluid, be conducive to the absorption of medicine, serve the effect of protection wound surface, and have the effect of promotion epithelial cell growth to wound surface.Have the effect of anti-inflammation, heat clearing and damp drying, eliminating fire and detoxication, the present invention also has easy to use, i.e. not pollution clothes, makes again wound surface from advantages such as outside contamination.
Specific embodiments
Below in conjunction with specific embodiment, the present invention is further elaborated
embodiment 1:
Composition: Oleum Caryophylli 5g, Herba Lysimachiae foenum-graeci quintessence oil 25g, tea tree oil 20g, Oleum Folium Artemisiae Argyi 2g, Oleum Anisi Stellati 2g, Oleum Cinnamomi 1g, liquid paraffin 120g, Mentholum 25g.
Preparation method: take said medicine in proportion, by 25g Mentholum and 120g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 30r/min, on the magnetic stirring apparatus that temperature is 25 DEG C, slowly adds the Oleum Cinnamomi stirring 2h of the Oleum Caryophylli of 5g, 1g immediately, then other quintessence oils of residue are slowly added successively, continue to stir, until clear, get product.
embodiment 2:
Composition: Oleum Caryophylli 3g, Herba Lysimachiae foenum-graeci quintessence oil 30g, tea tree oil 15g, Oleum Folium Artemisiae Argyi 1g, Oleum Anisi Stellati 0.5g, Oleum Cinnamomi 0.5g, liquid paraffin 100g, Mentholum 45g.
Preparation method: take said medicine in proportion, by 45g Mentholum and 100g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 40r/min, on the magnetic stirring apparatus that temperature is 30 DEG C, slowly adds the Oleum Cinnamomi stirring 1h of the Oleum Caryophylli of 3g, 0.5g immediately, then other quintessence oils of residue are slowly added successively, continue to stir, until clear, get product.
embodiment 3:
Composition: Oleum Caryophylli 2g, Herba Lysimachiae foenum-graeci quintessence oil 15g, tea tree oil 25g, Oleum Folium Artemisiae Argyi 0.8g, Oleum Anisi Stellati 0.2g, Oleum Cinnamomi 2g, liquid paraffin 80g, Mentholum 30g.
Preparation method: take said medicine in proportion, by 30g Mentholum and 80g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 30r/min, on the magnetic stirring apparatus that temperature is 40 DEG C, slowly adds the Oleum Cinnamomi stirring 3h of the Oleum Caryophylli of 2g, 2g immediately, then other quintessence oils of residue are slowly added successively, continue to stir, until clear, get product.
embodiment 4:
Composition: Oleum Caryophylli 4g, Herba Lysimachiae foenum-graeci quintessence oil 20g, tea tree oil 18g, Oleum Folium Artemisiae Argyi 1.5g, Oleum Anisi Stellati 1g, Oleum Cinnamomi 0.8g, liquid paraffin 115g, Mentholum 20g.
Preparation method: take said medicine in proportion, by 20g Mentholum and 115g liquid paraffin, after dissolving in 40 DEG C of water-baths, being placed in rotating speed is 30r/min, on the magnetic stirring apparatus that temperature is 25 DEG C, slowly adds the Oleum Cinnamomi stirring 2h of the Oleum Caryophylli of 4g, 0.8g immediately, then other quintessence oils of residue are slowly added successively, continue to stir, until clear, get product.
drug effect of the present invention is as follows:
extracorporeal bacteria inhibitor test
1) medicine: the embodiment 1 prepared according to the present invention, embodiment 2, embodiment 3, embodiment 4, matched group 1(mono-kind treat the compound essential Oil of skin burn, scald, the patent No. is CN101199772A), matched group 2(mono-kind improves the compound essential Oil of skin properties, the patent No. is CN102397182A)
2) culture medium: MH culture medium, Sabouraud's agar culture medium, LB agar culture medium.
3) experimental strain: staphylococcus aureus, escherichia coli, bacillus pyocyaneus, each 5 strains of Candida albicans, Nat'l Pharmaceutical & Biological Products Control Institute provides.
4) method: adopt the preparation of K-B standard technique, inoculation bacterium liquid, with swab, bacterium liquid is coated whole media surface, then compound liniment stock solution 5ul is drawn on the filter paper of 6mm, be affixed on containing bacterium dull and stereotyped immediately, often kind of strain do three parallel, cultivate in calorstat after 16-18 hour, measure antibacterial circle diameter (mm), judge fungistatic effect.
5) result: measurement result sees the following form
| Staphylococcus aureus | Candida albicans | Escherichia coli | Bacillus pyocyaneus | |
| Blank group | - | - | - | - |
| Embodiment 1 | 14.95 | 15.20 | 14.78 | 14.52 |
| Embodiment 2 | 12.92 | 13.88 | 11.16 | 12.25 |
| Embodiment 3 | 10.65 | 11.20 | 10.98 | 11.74 |
| Embodiment 4 | 11.15 | 12.74 | 12.10 | 11.58 |
| Matched group 1 | 7.82 | 8.12 | 8.25 | 7.26 |
| Matched group 2 | 8.36 | 8.27 | 8.46 | 7.38 |
Experimental result shows, the present invention causes the various antibacterial of infection and the fungistatic effect of fungus to be significantly better than the compound essential Oil that matched group 1(mono-kind treats skin burn, scald for burn and scald secondary, the patent No. is CN101199772), matched group 2(mono-kind improves the compound essential Oil of skin properties, the patent No. is CN102397182A).
below in conjunction with clinical experiment, the beneficial effect of the present invention in treatment verruca plana is described
One, we are extensive in clinical practice for many years, treatment 100 routine patients, and curative effect is frequently good.
Two, diagnostic criteria: flat defect is a kind of viral skin infectious disease, is common in adolescence, shows as many points of cloth covers
Portion, the back of the hand and neck, foxtail millet grain is large to Semen phaseoli radiati, quality is soft, top is smooth, light brown or the flat pimple exceeding skin surface.Lab testing: papillomavirus HPv3 and HPv5 can be found.
Three, Therapeutic Method: by a kind of vegetable oil compound liniment for the treatment of burn and scald of the present invention, smears affected part, every day 2-3 time sooner or later; First quarter moon is a course for the treatment of, uses 4-6 the course for the treatment of.
Four, criterion of therapeutical effect: cure: deflorescence, without newly going out erythra; Take a turn for the better: erythra comparatively before flattens, and disappears more than 30%, or have indivedual new rash to occur; Do not heal: erythra is unchanged or disappear less than 30%.
Therapeutic outcome: the present invention treats 100 examples, uses 4 courses for the treatment of, result cures 94 examples, effective 5 examples, invalid 1 example.
Model case
Case 1:
, 32 years old, there is facial flushes scratchiness in Liu x, occurs that little pimple is as large in Semen Glycines before the several months, living closely together in flakes, is verruca plana through examination in hospital, and after using 1 course for the treatment of of medicine of the present invention (embodiment 1), the colour of skin normally, scratchiness alleviates, after continuing 3 courses for the treatment of of use, symptom disappears entirely, now fully recovers.
Case 2:
Beam, 19 years old, suffers from verruca plana, at left cheek, shows as the flat pimple of normal color, distributes in flakes, have diffusion tendency.After using 1 course for the treatment of of medicine of the present invention (embodiment 2), wart body diminishes, and does not have diffusion, after continuing for 4 courses for the treatment of, disappears, cures, recurrence that so far there are no.
Case 3:
Chen, man, 22 years old.The flat pimple that facial and the back of the hand occurs that quality is soft, foxtail millet grain is large to Semen phaseoli radiati, exceeds skin surface, arranges in suffering from pearl along scratch because scratching.Antiallergic agent poor effect is taken in community hospital.Lab testing: visible papillomavirus HPv5, patient uses medicine of the present invention (embodiment 3), and and guide and avoid irritable food, clinical symptoms disappears completely, follows up a case by regular visits to half a year and does not recur again.
Case 4:
Wang, female, 24 years old.There is the flat pimple exceeding skin surface in forearm and skin of dorsum of hand, is diagnosed verruca plana, through laser therapy in local County Hospital, surface skin pathological changes is difficult to eliminate, and within nearly 1 week, comes, again repeatedly, forearm and the back of the hand occur that foxtail millet grain is large to Semen phaseoli radiati, raised skin flat pimple.Lab testing: can find papillomavirus HPV3, patient uses medicine of the present invention (embodiment 1), and clinical symptoms disappears completely, follows up a case by regular visits to half a year and does not recur again.
Case 5:
Song, man, 21 years old.March front face and chest there is being dispersed in property flat pimple, treat at this hospital of village ointment, take a turn for the better again repeatedly, lab testing: visible papillomavirus HPV5, patient uses medicine of the present invention (embodiment 2), and clinical symptoms disappears completely, and lab testing is normal.Follow up a case by regular visits to half a year and do not recur again.
to the experimentation of mice H degree scalding model
Wistar rat 80, experiment is sloughed rat back with 8% sodium sulfide and is about 25cm the previous day
2hair.Test the same day, diameter, with after ether per nasal inhalation anesthesia, is that the copper post of 2.0cm puts into boiling water to copper post constant temperature by rat, naturally vertically places 10s, burn surface perusal: subcutaneous outward appearance pale muddiness or pale brown, dry tack free at depilation position.Sick inspection under microscope: skin surface covers degeneration necrosis thing, all there is coagulation necrosis and in homogenizing in skin layers and accessory structure and subcutaneus adipose tissue; Telangiectasis, erythrocyte is retarded by silt, and have thrombosis, edema is obvious; Muscle fiber original structure disappears and merges mutually, flesh karyopycnosis, can be decided to be III degree of scald.80 rats of scalding are divided into immediately 8 groups [blank group, model group (do not give any medicine), embodiment 1, embodiment 2, embodiment 3, embodiment 4, matched group 1(mono-kind treat the compound essential Oil of skin burn, scald, the patent No. is CN101199772), matched group 2(mono-kind improves the compound essential Oil of skin properties, the patent No. is CN102397182A)].After model preparation, apply medicinal lotion or ointment respectively at injury for each group, successive administration 21d, every day 2 times.In experimentation, position Wound healing rate and wound healing time are scalded in observation.Experimental result is as following table:
Wound healing rate (%)
| Group | 7th day | 20th day |
| Model group | 14 | 70 |
| Blank group | 15 | 78 |
| Embodiment 1 | 43 | 100 |
| Embodiment 2 | 39 | 98 |
| Embodiment 3 | 32 | 90 |
| Embodiment 4 | 35 | 94 |
| Matched group 1 | 30 | 85 |
| Matched group 2 | 28 | 83 |
Wound healing time (my god)
| Group | Animal/only | Healing time/sky |
| Model group | 10 | 35 |
| Blank group | 10 | 28 |
| Embodiment 1 | 10 | 14 |
| Embodiment 2 | 10 | 20 |
| Embodiment 3 | 10 | 16 |
| Embodiment 4 | 10 | 18 |
| Matched group 1 | 10 | 26 |
| Matched group 2 | 10 | 28 |
Experimental result shows, the present invention contributes to the healing of skin wound very much, Be very effective is better than the compound essential Oil that matched group 1(mono-kind treats skin burn, scald, the patent No. is CN101199772), matched group 2(mono-kind improves the compound essential Oil of skin properties, the patent No. is CN102397182A).
model case:
Case 1:
Week certain, man, 30 years old, accidentally kick down thermos flask, left sufficient face is burned, the blister that scald face differs in size as seen, and severe pain punctures the blister at empyrosis place with aseptic syringe needle, the whole damage surface of normal saline flushing, dries injury with Aseptic sterilisation Cotton Gossypii, fully recovers, without cicatrix after smearing 3 times by embodiment 1.
Case 2:
Wang, man, 20 years old, is scalded the right hand by hot water, scalds and meets personally the blister differed in size, have several bubble skin to come off as seen.After smearing embodiment 2, without pain, medication was obviously healed at skin exfoliation place after 7 days.
Case 3:
Grandson, female, 3 years old, is in when playing and is scalded bottom right arm by hot water, sees that the bottom right skin of arm redness companion right hand has the blister differed in size, cries and screams more than.Fully recover, without cicatrix after smearing embodiment 3.
Case 4:
Liao, man, blast in the process of frying potassium nitrate, whole body burn surface area reaches 60%, and major part belongs to deep third degree burn, adopts embodiment 3 to treat, every day 3-5 time, recovery from illness in 35 days, preventing from scar.
Case 5:
Wei, female, because pressure cooker blast causes facial rats after severe scald burn, fully recover after treating 6 days through using embodiment 1, face does not stay cicatrix.
Case 6:
Lu, female, because of liquefied gas blast burn whole body, whole body burn surface area is more than 50%, and two lower limb deep second degree burn, belongs to large-area burns, fully recovers, more after without scratchiness after smearing 26 days through using embodiment 2.Further consultation after 1 year, upper limb, face, cervical region are substantially without cicatrix.
Above-mentioned explanation is not limitation of the present invention, and the present invention is not limited to above-mentioned example, those skilled in the art, and in essential scope of the present invention, the change made, change, interpolation or replacement, all should belong to protection scope of the present invention.
Claims (4)
1. treat a vegetable oil compound liniment for burn and scald, it is characterized in that being prepared from by following raw material proportioning:
Oleum Caryophylli 2-15, Herba Lysimachiae foenum-graeci quintessence oil 15-30, tea tree ethereal oil 15-25, Oleum Folium Artemisiae Argyi 0.8-2, Oleum Anisi Stellati 0.2-2, Oleum Cinnamomi 0.5-2, liquid paraffin 80-120, Mentholum 20-45.
2. a kind of vegetable oil compound liniment for the treatment of burn and scald according to claim 1 is prepared from by the raw material of following optimum weight part proportioning:
Oleum Caryophylli 5, Herba Lysimachiae foenum-graeci quintessence oil 25, tea tree ethereal oil 20, Oleum Folium Artemisiae Argyi 2, Oleum Anisi Stellati 2, Oleum Cinnamomi 1, liquid paraffin 120, Mentholum 25.
3. a kind of preparation method for the treatment of the vegetable oil compound liniment of burn and scald described in claim 1 or 2, comprises the following steps:
Take said medicine in proportion, Mentholum and liquid paraffin are dissolved in water-bath, add Oleum Cinnamomi immediately, Oleum Caryophylli is placed on magnetic stirring apparatus and stirs, then add remaining quintessence oil in proportion successively to continue to stir, whipping temp is 20-50 DEG C, and mixing speed is 30-60 rev/min, and mixing time is 1-5 hour, until clear, to obtain final product.
4. a kind of vegetable oil compound liniment for the treatment of burn and scald described in claim 1 or 2, it is characterized in that, said composition adds other adjuvant such as solubilizing agent or nonaqueous solvent and can be made into gel, ointment, spray, lotion, suppository etc. for the disinfectant of skin and mucosa, pasteurization towelette, antiseptic gauze, the various sterile products such as adhesive bandage, can also the multi-form or object such as health and daily chemical products use.
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Cited By (4)
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| CN106236835A (en) * | 2016-08-15 | 2016-12-21 | 湖南仁馨生物技术有限公司 | A kind of plants essential oil spray and its preparation method and application |
| CN106728166A (en) * | 2016-12-20 | 2017-05-31 | 淄博高新技术产业开发区生物医药研究院 | Treat the Chinese medicine composition of eczema |
| CN108355085A (en) * | 2018-05-21 | 2018-08-03 | 江苏艾桐医疗科技有限公司 | A kind of lavender oil formula prepares the application in cicatrix of skin |
| CN113699001A (en) * | 2020-05-20 | 2021-11-26 | 张勇 | Compatibility method of food material foot washing soap (paste) |
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| CN106728166A (en) * | 2016-12-20 | 2017-05-31 | 淄博高新技术产业开发区生物医药研究院 | Treat the Chinese medicine composition of eczema |
| CN106728166B (en) * | 2016-12-20 | 2020-05-26 | 淄博高新技术产业开发区生物医药研究院 | Traditional Chinese medicine composition for treating eczema dermatitis |
| CN108355085A (en) * | 2018-05-21 | 2018-08-03 | 江苏艾桐医疗科技有限公司 | A kind of lavender oil formula prepares the application in cicatrix of skin |
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