CN101401890B - External use medicament capable of effectively treating wound surface infection - Google Patents
External use medicament capable of effectively treating wound surface infection Download PDFInfo
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- CN101401890B CN101401890B CN2008103046266A CN200810304626A CN101401890B CN 101401890 B CN101401890 B CN 101401890B CN 2008103046266 A CN2008103046266 A CN 2008103046266A CN 200810304626 A CN200810304626 A CN 200810304626A CN 101401890 B CN101401890 B CN 101401890B
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Abstract
The invention relates to a traditional Chinese medicine preparation, namely an external medicine which can effectively treat the infection of wound surfaces. The Chinese medicine preparation consists of the following raw material medicines or auxiliary materials in weight portion: 3 to 5 portions of phellodendron, 2 to 5 portions of dandelion, 2 to 5 portions of rhubarb, 2 to 5 portions of rhizoma coptidis. 1 to 3 portions of borneol, 1 to 3 portions of myrrh, 0.5 to 1.5 portions of dragon's blood, 1 to 3 portions of cuttlebone, 1 to 3 portions of corydalis tuber, 0.5 to 1.5 portions of hop, 0.5 to 1.5 portions of ginseng and 0 to 15 portions of starch. The Chinese medicine preparation has the functions of clearing away heat and detoxifying, promoting blood circulation by removing blood stasis, relieving swellings and pains, removing decay, promoting tissue regeneration, absorbing moistness and converging wound and mainly treats various chronic ulcer of skin caused by skin injury. Theclinic application of the Chinese medicine preparation by 60 patients shows that the total effective rate is between 86.7 and 93.3 percent. The Chinese medicine preparation treats the residual wound surface in the late stage of burning through immersion bath, and can promote the healing of the residual wound surface and shorten the course of disease.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, can effectively treat the medicine for external use of traumatic infection.
Background technology
In prior art, the general treatment principle of traumatic infection is the protection wound surface, and minimizing is oozed out.The existence of wound surface is the basic problem of burn overall process after the burn, especially the most difficult with the treatment of residual wound, often occur in the later stage of burn treating, because the course of disease is longer, wound surface is aging, edema, drug-resistant bacteria infects in addition, and methods such as the dipping bath of changing dressings by wound surface are previously handled and are difficult to make residual wound healing fully at short notice, have increased nursing work load and patient's hospital stays and expense.How promoting the healing of residual wound, is the problem of generally being concerned about in the burn treating nursing process.Treatment traumatic infection medicament categories is various in the reality, and curative effect is different.
Summary of the invention
The purpose of this invention is to provide a kind of curative effect and can effectively treat the medicine for external use of traumatic infection reliably.
Technical solution of the present invention is: a kind of medicine for external use that can effectively treat traumatic infection, make by following weight crude drug or adjuvant: Cortex Phellodendri 3-5 part, Herba Taraxaci 2-5 part, Radix Et Rhizoma Rhei 2-5 part, Rhizoma Coptidis 2-5 part, Borneolum Syntheticum 1-3 part, Myrrha 1-3 part, Sanguis Draxonis 0.5-1.5 part, Endoconcha Sepiae 1-3 part, Rhizoma Corydalis 1-3 part, Fructus Cnidii 0.5-1.5 part, Radix Ginseng 0.5-1.5 part, starch 0-15 part.
We institute medication heat-clearing and toxic substances removing is a monarch drug, as Cortex Phellodendri, Herba Taraxaci, Radix Et Rhizoma Rhei, Rhizoma Coptidis.Activating blood circulation to dissipate blood stasis is a ministerial drug, as Myrrha, Sanguis Draxonis.Removing dampness is held back wound, reducing swelling and alleviating pain is an adjuvant, as Radix Ginseng, Borneolum Syntheticum, Endoconcha Sepiae, Rhizoma Corydalis, Fructus Cnidii.
Method for making: Cortex Phellodendri, Herba Taraxaci, Radix Et Rhizoma Rhei, Myrrha, Rhizoma Corydalis, use 95% alcohol-pickled 48 hours (sealing) in proportion, dry, pulverize, sieve, remove slag.Rhizoma Coptidis, Borneolum Syntheticum, Sanguis Draxonis, Fructus Cnidii, Radix Ginseng, Endoconcha Sepiae are pulverized (120 order), the processed with wine extract are stirred in together again, and step makes finished product (as sterilization etc.) according to a conventional method again.Can join being mixed with acceptable auxiliary or the like on the pharmacopedics as required, as starch.
Function: heat-clearing and toxic substances removing, activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain, putrefaction removing and tissue regeneration promoting, removing dampness are held back wound.
Cure mainly: the chronic skin ulcer that various skin injurys cause.
Usage: with the allotment of normal saline 1:3 ratio, be coated with exposure or wrapping outward, change dressings once every day.
Advantage of the present invention is: 1, science is complete more for this formula and prescription, antiinflammatory, sterilization, disinfectant medicine are promptly arranged, particularly the synergism of several medicines should be a best of breed, cooperates activating blood circulation to dissipate blood stasis medicine and removing dampness to hold back the medicine of wound reducing swelling and alleviating pain again, and this is unexistent in conventional formulation.2, have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, putrefaction removing and tissue regeneration promoting, removing dampness and hold back wound, promote granulation tissue and skin functions such as growth fast that especially infection has obvious sterilization and bacteriostasis to common bacterias such as the bacillus pyocyaneus on the residual wound, staphylococcus aureuses.3, use total effective rate 86.7-93.3% through clinical 60 routine patients.Dipping bath treatment burn later stage residual wound can promote the healing of residual wound, shortens the course of disease.
Below in conjunction with embodiment embodiments of the present invention are described in further detail.
The specific embodiment
Embodiment 1
Can effectively treat the medicine for external use of traumatic infection, it is made by effective ingredient and acceptable accessories, and effective ingredient is wherein made by following weight raw material: 4 parts of Cortex Phellodendris, 4 parts of Herba Taraxacis, 4 parts of Radix Et Rhizoma Rhei, 4 parts of Rhizoma Coptidis, 2 parts of Borneolum Syntheticums, 2 parts of Myrrhas, 1 part of Sanguis Draxonis, 2 parts of Endoconcha Sepiaes, 2 parts of Rhizoma Corydalis, 1 part of Fructus Cnidii, 1 part of Radix Ginseng.
Embodiment 2
Can effectively treat the medicine for external use of traumatic infection, it is made by effective ingredient and acceptable accessories, and effective ingredient is wherein made by following weight raw material: 4 parts of Cortex Phellodendris, 4 parts of Herba Taraxacis, 4 parts of Radix Et Rhizoma Rhei, 4 parts of Rhizoma Coptidis, 2 parts of Borneolum Syntheticums, 2 parts of Myrrhas, 1 part of Sanguis Draxonis, 2 parts of Endoconcha Sepiaes, 2 parts of Rhizoma Corydalis, 1 part of Fructus Cnidii, 1 part of Radix Ginseng, 10 parts of starch.
The test example
The existence of wound surface is the basic problem of burn overall process after the burn, especially the most difficult with the treatment of residual wound, often occur in the later stage of burn treating, because the course of disease is longer, wound surface is aging, edema, drug-resistant bacteria infects in addition, and methods such as the dipping bath of changing dressings by wound surface are previously handled and are difficult to make residual wound healing fully at short notice, have increased nursing work load and patient's hospital stays and expense.How promoting the healing of residual wound, is the problem of generally being concerned about in the burn treating nursing process.Residual wound to 60 routine deep burn patient's later stages carries out the treatment of Chinese medicine dipping bath, receives satisfied effect, now is reported as follows.
1, clinical data
60 routine deep burn patients to accepting for medical treatment are divided into partial immersion bath and full bath according to burn surface area and residual wound distribution situation.The partial immersion bath residual wound is distributed in hands, foot, forearm, shank and amounts to 30 examples, wherein male's 24 examples, women's 6 examples, age 12-65 year, average 43 years old, burn surface area 9%-50%, average (20 ± 4.5) %TBSA.Residual wound 14 examples that dark II degree forms, skin-grafting back residual wound 6 examples.Full bath 30 examples, male's 26 examples wherein, women's 4 examples, age 14-68 year, average 45 years old, burn surface area 42%-95%, average (52 ± 9.3) %TBSA.Residual wound 18 examples that dark II degree forms, skin-grafting back residual wound 8 examples, III degree residual wound 4 examples.
2, Therapeutic Method
2.1 partial immersion bath 30 examples are divided into two groups at random, experimental group 15 examples are implemented dipping bath.Matched group 15 examples are implemented 1: 1000 bromo geramine solution dipping bath.Generally carry out during dipping bath at the ward bedside.Get a dark basin of double layer disinfecting rustless steel and put warm water 8000-10000 milliliter, 1 bag (10g) of getting it filled is put in the water and fully stirs, and debugs water temperature to 38-39 ℃ with water thermometer, to there be the limbs of residual wound to be immersed in the solution, the patient of movable gently limbs, the particularly burn of hand, the motion between encouraging to do to point, gauze, pus and the slough on the wound surface adhered in removal, keep water temperature, each dipping bath 30 minutes, every day 1 time, 1 week was 1 course of treatment, carried out 2 courses of treatment altogether.The matched group method is the same.
2.2 full bath 30 examples also are divided into two groups at random, experimental group 15 examples are implemented the Chinese medicine dipping bath, and matched group 15 examples are implemented 1: 1000 bromo geramine solution dipping bath.At first regulate dipping bath chamber room temperature to 32-34 ℃, put warm water to bathtub half, 8 bags (80g) of getting it filled are put in the water fully and mix, debug water temperature to 38-39 ℃ with water thermometer, then sick bed is pushed into the dipping bath chamber, patient is moved to hammock hang up hook, press lifting button, hammock mentioned slowly exceed bathtub, level moves to bathtub top, presses lifting button again, with hammock submerged slowly, patient only need expose incidence, and all the other positions are immersed in the water.The nursing staff puts on sterile gloves, constantly stirs dipping bath liquid, encourages patient to do the motion in each joint of limbs in water, remove the internal layer gauze after making wound surface fully softening, remove pus crusts and slough, and keep water temperature, soaked 20-30 minute, and at last hammock was risen to the water surface, use the warm water washing whole body, blot patient's water on one's body with aseptic sterilization yarn pad, patient is moved to sick bed, covers quilt and deliver to ward, the next day 1 time, 1 week was 1 course of treatment, carried out 2 courses of treatment altogether.The matched group method is the same.
3, curative effect is passed judgment on: carry out clinical assessment according to wound healing degree and time.
(1) healing: residual wound normal healing, complete closed.
(2) produce effects: wound surface oozes out obvious minimizing, and wound Zhou Mingxian dwindles, and has epithelium to creep.
(3) effective: wound surface oozes out to some extent and reduces, and wound reduces in week.
(4) invalid: as to need skin-grafting to eliminate wound surface.
4, result
Two groups of curative effects relatively
Partial immersion bath compares X with matched group
2=3.68, P＜0.05; Full bath compares X with matched group
2=2.62, P＜0.05;
5, discuss
Deep burn especially degree of depth large-area burns patient the treatment later stage, because nosocomial infection, the skin-grafting gap is too big, the granulation hyperplasia, blister formation, friction, ulceration behind the wound healing residue in secretions such as intradermal sebaceous gland, sweat gland behind the dark II degree wound healing and get clogged, and form reasons such as the little Xiang Pao infection of retention, ulceration, the residual wound that formation is healed than refractory, and the infection of drug-resistant bacteria very easily takes place in the wound surface that these difficulties heal.These antibacterials mostly are staphylococcus aureus, bacillus pyocyaneus, escherichia coli and Mycophyta greatly, even change dressings repeatedly, even reach more than 1 year, and wound surface also can't heal, and bring huge misery for patient's body and mind.Our bromo geramine solution dipping bath commonly used of past, though can remove slough, the cleaning wound surface, blood circulation promoting behind the dipping bath, wound surface humidity, edema, oozes out manyly, influences wound healing.This group experimental group is used this medicine dipping bath and is obtained obvious curative effects.This medicine (claiming Chinese medicine again No. 1) is made up of Chinese medicines such as Cortex Phellodendri, Herba Taraxaci, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Borneolum Syntheticum, Myrrha, Sanguis Draxonis, Endoconcha Sepiae, Rhizoma Corydalis, hops, Radix Ginsengs, modern Chinese medicine studies show that have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, putrefaction removing and tissue regeneration promoting, removing dampness are held back wound, promote granulation tissue and skin functions such as growth fast, especially infection has obvious sterilization and bacteriostasis to common bacterias such as the bacillus pyocyaneus on the residual wound, staphylococcus aureuses.Health is immersed in the hot water, utilize hydrostatic pressure and buoyancy of water effect, promote the backflow of venous blood, reduce the formation of blister, increase the mobility in each joint, help the recovery of limb function, this shows, No. 1 dipping bath treatment of Chinese medicine burn later stage residual wound can promote the healing of residual wound, shortens the course of disease.
Claims (3)
1. the medicine for external use that can effectively treat traumatic infection, it is characterized in that making: Cortex Phellodendri 3-5 part, Herba Taraxaci 2-5 part, Radix Et Rhizoma Rhei 2-5 part, Rhizoma Coptidis 2-5 part, Borneolum Syntheticum 1-3 part, Myrrha 1-3 part, Sanguis Draxonis 0.5-1.5 part, Endoconcha Sepiae 1-3 part, Rhizoma Corydalis 1-3 part, Fructus Cnidii 0.5-1.5 part, Radix Ginseng 0.5-1.5 part, starch 0-15 part by following weight crude drug or adjuvant.
2. according to the described medicine for external use that can effectively treat traumatic infection of claim 1, it is characterized in that 4 parts of Cortex Phellodendris, 4 parts of Herba Taraxacis, 4 parts of Radix Et Rhizoma Rhei, 4 parts of Rhizoma Coptidis, 2 parts of Borneolum Syntheticums, 2 parts of Myrrhas, 1 part of Sanguis Draxonis, 2 parts of Endoconcha Sepiaes, 2 parts of Rhizoma Corydalis, 1 part of Fructus Cnidii, 1 part of Radix Ginseng.
3. according to the described medicine for external use that can effectively treat traumatic infection of claim 1, it is characterized in that 4 parts of Cortex Phellodendris, 4 parts of Herba Taraxacis, 4 parts of Radix Et Rhizoma Rhei, 4 parts of Rhizoma Coptidis, 2 parts of Borneolum Syntheticums, 2 parts of Myrrhas, 1 part of Sanguis Draxonis, 2 parts of Endoconcha Sepiaes, 2 parts of Rhizoma Corydalis, 1 part of Fructus Cnidii, 1 part of Radix Ginseng, 10 parts of starch.
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| CN2008103046266A CN101401890B (en) | 2008-06-06 | 2008-09-24 | External use medicament capable of effectively treating wound surface infection |
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| CN2008103046266A CN101401890B (en) | 2008-06-06 | 2008-09-24 | External use medicament capable of effectively treating wound surface infection |
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| CN101401890B true CN101401890B (en) | 2011-03-23 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102961479B (en) * | 2012-12-14 | 2014-11-19 | 重庆市科学技术研究院 | Plastics for promoting healing of skin wound and preparation method of plastics |
| CN103948907A (en) * | 2014-05-26 | 2014-07-30 | 通化昌源医药科技有限公司 | External traditional Chinese medicine powder capable of effectively treating chilblain and freezing injury and preparation method thereof |
| CN103977194A (en) * | 2014-05-26 | 2014-08-13 | 通化昌源医药科技有限公司 | Application of drug for external use capable of effectively treating wound infection in preparing medicaments for treating diabetic foot |
| CN105169173A (en) * | 2015-07-14 | 2015-12-23 | 江涛 | Traditional Chinese medicinal external lotion for treating infective wounds caused by multi-drug resistant bacteria |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1133735A (en) * | 1995-04-18 | 1996-10-23 | 吴慧奎 | "Longfenghehuan" wine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1133735A (en) * | 1995-04-18 | 1996-10-23 | 吴慧奎 | "Longfenghehuan" wine |
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