CN113350259A - Repairing and nourishing composition for infant with impaired skin sensitive and dry barrier function - Google Patents
Repairing and nourishing composition for infant with impaired skin sensitive and dry barrier function Download PDFInfo
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- CN113350259A CN113350259A CN202011491612.7A CN202011491612A CN113350259A CN 113350259 A CN113350259 A CN 113350259A CN 202011491612 A CN202011491612 A CN 202011491612A CN 113350259 A CN113350259 A CN 113350259A
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- infants
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- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a repairing and nourishing composition for an infant, which is used for treating impaired skin sensitivity and dryness barrier function, and consists of 100 parts by weight of water, 1-20 parts by weight of humectant, 1-10 parts by weight of emulsifier, and 0.01-1 part by weight of two-row yeast; and 0.01-1 part by weight of probiotics, the formula of the invention contains two series of yeasts, probiotics and various precious plant grass extracts, has excellent moisturizing effect, is a low-sensitivity formula, contains amino acid components, and is easy to absorb by small molecules and safer. The invention is suitable for infants and children to repair and nourish sensitive skin, dry skin and damaged skin barrier function.
Description
Technical Field
The invention relates to a repairing and nourishing composition for repairing and nourishing an infant, which is used for repairing and nourishing an infant, wherein the skin sensitive and dry barrier function of the infant is damaged. The invention is suitable for infants and children to repair and nourish sensitive skin, dry skin and damaged skin barrier function.
Background
The moisture retention is an important physiological function of the skin, the tenderness degree of the skin mainly depends on the water content of the horny layer of the epidermis of the skin, the horny layer of the skin is very thin and contains bound water and free water, and when the bound water reaches a saturated state, the excess water can form the free water. After the infant has been born, the skin does not develop completely, and it takes about 3 years to develop to the same level as that of an adult. Compared with adults, infants have inactive sebaceous gland function, less secretion and relatively dry skin, so the infants need skin moisturizing care more than the adults.
The humectant is a water-soluble substance with high hygroscopicity, and can supplement water to skin and prevent skin dryness. Commonly used moisturizers are of class 4: 1. the grease for preventing water evaporation is moisturized; 2. moisture absorption and moisture preservation for absorbing external moisture; 3. hydration moisturization in combination with hydration; 4. repairing and moisturizing keratinocyte. The traditional moisturizers comprise glycerol, 1, 2-propylene glycol, 1, 3-butylene glycol, sorbitol, sodium pyrrolidone carboxylate, polyethylene glycol, sodium lactate and the like, and most of the moisturizers are synthesized artificially.
Therefore, with the increase of safety awareness of consumers, the market demand for highly effective moisturizing active ingredients for infants, which are naturally derived, safe, and low in cost, is increasing.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a repairing and nourishing composition for infants to treat the impaired sensitive and dry barrier function of skin, which consists of 100 parts by weight of water, 1-20 parts by weight of humectant, 1-10 parts by weight of emulsifier and 0.01-1 part by weight of yeast.
As a preferable technical scheme, the repairing and nourishing composition also comprises 0.01-1 part by weight of probiotics.
As a preferred technical scheme, the repairing and nourishing composition also comprises 0.01-1 part by weight of plant herbal extract;
the herbal extract is a mixture of radix astragali (Astragalus membranaceus) root extract, radix Saposhnikoviae (Saposhnikovia divaricata) root extract, herba Sidae Rhombifoliae (Calendala officinalis) flower extract, flos Albizziae (Albiziajulibrissin) flower extract, and rhizoma Gastrodiae (Gastrodia Elata) root extract.
As a preferable technical scheme, the repairing and nourishing composition further comprises 0.01-1 part by weight of biological sugar gum solution, and the content of the biological sugar gum in the biological sugar gum solution is 1-20 wt%.
As a preferable technical scheme, the repairing and nourishing composition further comprises 0.01-1 part by weight of an amino acid solution, and the content of the micromolecule amino acid in the amino acid solution is 1-30 wt%.
As a preferable technical scheme, the humectant is selected from one or more of glycerin, butanediol, sodium hyaluronate, 1, 2-hexanediol, butanediol and 1, 3-propylene glycol.
As a preferable technical scheme, the repairing and nourishing composition also comprises 1-5 parts by weight of preservative which is selected from one or two of allantoin and panthenol.
As a preferable technical scheme, the repairing and nourishing composition also comprises 1-5 parts by weight of antioxidant, wherein the antioxidant is selected from one or more of VE acetate, AVC and ceramide.
As a preferable technical scheme, the repairing and nourishing composition also comprises 1-5 parts by weight of emulsifier, wherein the emulsifier is one or more selected from C14-22 alcohol, C12-20 alkyl glucoside, cetearyl alcohol and cetearyl glucoside.
As a preferable technical scheme, the repairing and nourishing composition also comprises 1-5 parts by weight of an emollient, and the emollient is selected from one or more of caprylic/capric triglyceride, cetostearyl alcohol, shea butter (Butyrpermumparkii), polydimethylsiloxane, squalane, jojoba (Simmondsiachinensis) seed oil and bioglycasin.
The formula of the invention contains two series of yeasts, probiotics and various precious plant grass extracts, has excellent moisturizing effect, is a low-sensitivity formula, contains amino acid components, and is easy to absorb by small molecules and safer. The invention is suitable for infants and children to repair and nourish sensitive skin, dry skin and damaged skin barrier function.
The above-described and other features, aspects, and advantages of the present application will become more apparent with reference to the following detailed description.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention without any inventive step, are within the scope of protection of the invention.
Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The use of "first," "second," and similar terms in the description and claims of the present application do not denote any order, quantity, or importance, but rather the terms are used to distinguish one element from another. Also, the use of the terms "a" or "an" and the like do not denote a limitation of quantity, but rather denote the presence of at least one.
A repairing and nourishing composition for infants and young children to treat impaired skin sensitive and dry barrier function is prepared from 100 parts by weight of water, 1-20 parts by weight of humectant, 1-10 parts by weight of emulsifier, and 0.01-1 part by weight of plant herbal extract;
the herbal extract is a mixture of radix astragali (Astragalus membranaceus) root extract, radix Saposhnikoviae (Saposhnikovia divaricata) root extract, herba Sidae Rhombifoliae (Calendala officinalis) flower extract, flos Albizziae (Albiziajulibrissin) flower extract, and rhizoma Gastrodiae (Gastrodia Elata) root extract.
As a preferred embodiment, the repairing and nourishing composition further comprises 0.01-1 part by weight of schizosaccharomyces cerevisiae.
As a preferred embodiment, the repairing and nourishing composition also comprises 0.01-1 part by weight of amino acid solution, and the content of small-molecule amino acid in the amino acid solution is 1-30 wt%.
As a preferred embodiment, the repairing and nourishing composition further comprises 0.01-1 parts by weight of lactobacillus extract, wherein the lactobacillus extract consists of 100 parts by weight of lactobacillus, 50-100 parts by weight of alpha-glucan oligosaccharide, 50-100 parts by weight of jerusalem artichoke (pomniasonchifolia) root juice and 50-100 parts by weight of maltodextrin.
As a preferred embodiment, the repairing and nourishing composition further comprises 0.01-1 part by weight of a biogel solution, wherein the content of biogel in the biogel solution is 1-20 wt%.
As a preferred embodiment, the humectant is one or more selected from glycerin, butylene glycol, sodium hyaluronate, 1, 2-hexanediol, butylene glycol and 1, 3-propylene glycol.
As a preferred embodiment, the repairing and nourishing composition also comprises 1-5 parts by weight of preservative which is one or two of allantoin and panthenol.
As a preferred embodiment, the repairing and nourishing composition also comprises 1-5 parts by weight of antioxidant, and the antioxidant is selected from one or more of VE acetate, AVC and ceramide.
As a preferred embodiment, the repairing and nourishing composition also comprises 1-5 parts by weight of emulsifier, wherein the emulsifier is one or more selected from C14-22 alcohol, C12-20 alkyl glucoside, cetearyl alcohol and cetearyl glucoside.
As a preferred embodiment, the repairing and nourishing composition further comprises 1-5 parts by weight of an emollient selected from one or more of caprylic/capric triglyceride, cetostearyl alcohol, shea butter (Butyrrumm parkii), dimethicone, squalane, jojoba (Simmondsiachinensis) seed oil, and bioglycan gum.
The formula of the invention contains various precious plant grass extracts, is a hypoallergenic formula and has better moisturizing effect. In addition, the invention also contains amino acid components, and the micromolecule amino acid is easy to absorb and is safer.
Examples
Composition of the herbal extract: 10 parts by weight of an extract from the root of Astragalus membranaceus (Astragalus membranaceus), 20 parts by weight of an extract from the root of Saposhnikovia divaricata (Saposhnikovia divaricata), 10 parts by weight of an extract from the flower of Marigold (Calendala officinalis), 20 parts by weight of an extract from the flower of Albizzia julibrissin (Albizia julibrissin), and 10 parts by weight of an extract from the root of Gastrodia elata (Gastrodia Elata).
The lactobacillus extract comprises 100 weight parts of lactobacillus, 100 weight parts of alpha-glucan oligosaccharide, 50 weight parts of yacon (POLYMNIASONCHIFOLIA) root juice, and 100 weight parts of maltodextrin.
The amino acid solution comprises 20wt% of micromolecule amino acid.
The biological carbohydrate gum solution comprises 10wt% of biological carbohydrate gum in the biological carbohydrate gum-4 solution.
The preparation process comprises the following steps:
(1) adding water in the formula into a water kettle, heating to 80 ℃, starting stirring, sequentially adding the materials 3, 8, 10, 14, 15, 16, 18, 19, 24 and 25, and uniformly stirring;
(2) adding the No. 2, 4, 5, 6, 7, 9, 20, 21 and 22 raw materials into an oil pan, heating to 80 ℃, and uniformly mixing;
(3) pumping the water phase and the oil phase into the main pot in sequence to homogenize the mixture evenly;
(4) cooling to 40 ℃, adding the raw materials 11, 12, 13, 17, 23, 26 and 27, and uniformly stirring;
(5) discharging after sampling detection meets the standard;
(6) inspecting the semi-finished product, filling after the semi-finished product is qualified, and packaging;
(7) and (5) inspecting a finished product, and warehousing after the finished product is qualified.
And (3) performance testing:
1. moisture retention test
Hyaluronic acid HA130W and distilled water were used as comparative examples, the moisturizing abilities of examples 1 to 3 were examined, 1% (w/w) aqueous solutions were prepared, and a CorneometerCM825 moisture test probe was connected to a multifunctional skin tester MPA10 of CK, Germany, and the moisturizing degree was measured according to QB/T4256-2011, guide for evaluation of moisturizing efficacy of cosmetics.
Test conditions and volunteer requirements
And (3) testing environmental conditions:
testing the environmental temperature: 20-22 ℃, humidity: 40% -60%, and real-time dynamic monitoring is carried out.
The number of the people who are the original people:
effective volunteers 24-30.
Volunteer conditions:
the age is between 18 and 65 years (excluding pregnant or lactating women). The capacitance skin moisture tester for the forearm test area has a basis value of 15-45 (Corneometer Unit, C.U.), and other capacitance testers can be calibrated by a Corneometer. Patients without severe systemic disease, immunodeficiency or autoimmune disease, and the subject site has not received skin treatment, cosmetic and other tests that may affect outcome. Those with inactive allergic diseases. Those without constitutional hypersensitivity. Hormone drugs and immunosuppressants have not been used in the last month. The test sites were not enrolled in other clinical trials now or in the last three months.
The test results show that the moisturizing ability of the hyaluronic acid in 20 minutes is respectively 62-90% higher than that of hyaluronic acid and is 161% higher than that of distilled water in 144-.
Multiple dosing skin irritation test
Animal experiments are adopted, healthy Japanese big-ear white rabbits (purchased from Qingdaokang Biotechnology Co., Ltd.) are adopted as experimental animals, 8 rabbits are taken, and male and female halves of the rabbits are randomly divided into 2 groups according to sex and weight: intact skin group and damaged skin group, 4 per group. 24 hours before administration, both sides of the backs of the rabbits were depilated with 8% (mass percent) sodium sulfide, and the depilated area was about 150cm 2. During the test, the upper area and the lower area on the left side of the skin are disinfected in a damaged skin depilating area by using an operation blade, the middle area on the right side is respectively marked with a 'well' -shaped crevasse, and the crevasses are respectively about 2cm in transverse and vertical directions and take the degree of blood seepage. In both groups, 0.1g of the composition of example 1 and 0.1g of the product of example 1 were applied uniformly to the upper and lower depilatory areas on the left side, and 1ml of physiological saline was applied to the right side as a control, once daily in the morning and afternoon for 7 consecutive days. During the application period, the animals are fed with the full-nutrition feed in cages. After 7 days of application, the product of example 1 and the product of application example 1 remained on the rabbit skin were washed out with warm water, and the skin irritation response score and intensity evaluation were performed by visual inspection and histopathological examination 1,2, 3, 4, 5, 6, and 7 days after the application of the drug and recording the presence or absence of erythema and edema of the skin at the application site.
Test results show that the rabbit skin care product has no irritation to intact skin and damaged skin of rabbits by using the examples 1 to 3 of the invention. The invention is proved to be non-irritant to the skin, safe and reliable. The invention is suitable for infants and children to repair and nourish sensitive skin, dry skin and damaged skin barrier function.
While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and the description is given here only for clarity, and those skilled in the art should integrate the description, and the embodiments may be combined appropriately to form other embodiments understood by those skilled in the art.
Claims (10)
1. The repairing and nourishing composition for the impaired skin sensitive and dry barrier function of infants is characterized by comprising 100 parts by weight of water, 1-20 parts by weight of humectant, 1-10 parts by weight of emulsifier and 0.01-1 part by weight of saccharomyces bifidus.
2. The restorative and nourishing composition for the impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, further comprising 0.01-1 part by weight of probiotics.
3. The restorative and nourishing composition for an infant with impaired skin sensitivity and dryness barrier function according to claim 1, further comprising 0.01-1 parts by weight of a herbal plant extract;
the herbal extract is a mixture of radix astragali (Astragalus membranaceus) root extract, radix Saposhnikoviae (Saposhnikovia divaricata) root extract, herba Sidae Rhombifoliae (Calendala officinalis) flower extract, flos Albizziae (Albiziajulibrissin) flower extract, and rhizoma Gastrodiae (Gastrodia Elata) root extract.
4. The repairing and nourishing composition for the impaired skin sensitivity and dryness barrier function of infants is characterized in that the repairing and nourishing composition also comprises 0.01-1 part by weight of amino acid solution, and the content of small molecular amino acid in the amino acid solution is 1-30 wt%.
5. The repairing and nourishing composition for the impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, wherein the repairing and nourishing composition further comprises 0.01-1 part by weight of a biogel solution, and the content of biogel in the biogel solution is 1-20 wt%.
6. The repairing and nourishing composition for the impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, wherein the moisturizing agent is one or more selected from glycerin, butylene glycol, sodium hyaluronate, 1, 2-hexanediol, butylene glycol and 1, 3-propylene glycol.
7. The restorative and nourishing composition for the impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, further comprising 1-5 parts by weight of a preservative selected from one or two of allantoin and panthenol.
8. The restorative nutrition composition for the impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, further comprising 1-5 parts by weight of an antioxidant, wherein the antioxidant is one or more selected from VE acetate, AVC and ceramide.
9. The restorative nourishing composition for the impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, further comprising 1-5 parts by weight of an emulsifier selected from one or more of C14-22 alcohol, C12-20 alkyl glucoside, cetearyl alcohol and cetearyl glucoside.
10. The restorative and nourishing composition for impaired skin sensitivity and dryness barrier function of infants and young children as claimed in claim 1, further comprising 1-5 parts by weight of an emollient selected from one or more of caprylic/capric triglyceride, cetostearyl alcohol, shea butter (Butyrrumm parkii), dimethicone, squalane, jojoba (Simmondsiachinensis) seed oil, and bioglycan.
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| CN103705426A (en) * | 2014-01-07 | 2014-04-09 | 梁云生 | Anti-allergic moisturizing composition with function of repairing skin barrier and external preparation thereof |
| CN108524381A (en) * | 2018-07-16 | 2018-09-14 | 广东卓明仕生物科技有限公司 | It is a kind of to be used to repair composition of skin barrier and its preparation method and application |
| CN109223607A (en) * | 2018-11-27 | 2019-01-18 | 权能(深圳)生物科技有限公司 | A kind of crease-resistant moisturizing cosmetic composition and cosmetics |
| CN109674734A (en) * | 2019-01-22 | 2019-04-26 | 郑娇娇 | It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect and its application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103705426A (en) * | 2014-01-07 | 2014-04-09 | 梁云生 | Anti-allergic moisturizing composition with function of repairing skin barrier and external preparation thereof |
| CN108524381A (en) * | 2018-07-16 | 2018-09-14 | 广东卓明仕生物科技有限公司 | It is a kind of to be used to repair composition of skin barrier and its preparation method and application |
| CN109223607A (en) * | 2018-11-27 | 2019-01-18 | 权能(深圳)生物科技有限公司 | A kind of crease-resistant moisturizing cosmetic composition and cosmetics |
| CN109674734A (en) * | 2019-01-22 | 2019-04-26 | 郑娇娇 | It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect and its application |
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