CN111991306A - Anti-aging repairing pure liquid, preparation method and application thereof - Google Patents
Anti-aging repairing pure liquid, preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61Q19/08—Anti-ageing preparations
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Abstract
The invention provides an anti-aging and repairing pure liquid, a preparation method and application thereof, wherein the anti-aging and repairing pure liquid is prepared from the following raw materials in percentage by mass: 5-10% of butanediol, 1-5% of glycerol, 2-10% of active substance, 0.05-0.20% of xanthan gum, 0.01-0.1% of sodium hyaluronate, 0.5-2% of 1, 2-hexanediol, 0.05-0.5% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.05-0.5% of pH regulator, 0.3-0.6% of p-hydroxyacetophenone and the balance of deionized water. The invention extracts and screens active ingredients in various plants with anti-aging and repairing effects, converts the obtained plant effect ingredients into water-soluble substances, and combines the water-soluble substances with polypeptides to form a pure solution with anti-aging and repairing effects and a preparation method thereof.
Description
Technical Field
The invention belongs to the technical field of cosmetic formulas, and particularly relates to an anti-aging and repairing pure liquid, a preparation method and application thereof.
Background
Skin aging is a complex series of biological processes within the skin tissue, and is the result of the combined action of all endogenous physiological factors and exogenous environmental factors. Skin aging affects not only normal skin tissue structure and physiological function, but also the appearance of the outer layer of the skin directly, thereby affecting the appearance. Therefore, anti-aging and anti-oxidation are highly regarded by beauty-seeking people.
The anti-aging products on the market are mainly used as development directions aiming at some common characteristics of people, including: fine lines and wrinkles, dull and yellowish complexion, under-eye bags, age spots, dry skin and cheek sagging. Generally, the anti-oxidation substance is supplemented to help reduce the generation of free radicals, moisturize and increase the skin elasticity, and meanwhile, collagen or enzyme is supplemented to effectively delay aging.
The natural plant extract is applied to cosmetics by the characteristics of 'green', 'safety', 'effective', 'wide source' and 'strong action mechanism pertinence', and at present, compound plant components are used when plant extraction system components are prepared, and compound components are developed, so that the effect of the compound plant extract is greater than that of a single plant extract; meanwhile, the peptide has a specific amino acid sequence, can regulate and control corresponding chemical reactions and biological reactions on the skin, such as pigmentation, inflammatory reactions, protein synthesis and the like, can be matched with plant extraction, and jointly achieves the aim of skin care through different action mechanisms.
The polypeptide has various biological activities on skin cells, and compared with polypeptides and proteins such as cell growth factors, the polypeptide with small molecular weight has higher skin permeability and is easier to be absorbed by a human body, meanwhile, the research on the basic biological mechanism of the anti-wrinkle active substance initiates the revolution of the polypeptide, and the polypeptide is applied to the field of cosmetics.
With the continuous development of science and technology, biological active substances are more and more disclosed, and further research and exploration of safe and effective anti-aging active substances become important subjects of research in the field.
Disclosure of Invention
In view of the above-mentioned situation, the present invention provides an anti-aging and repairing essence extract containing various plant extracts, a preparation method thereof, and a specific application thereof.
The purpose of the invention is realized by the following technical scheme:
the anti-aging and repairing pure liquid is prepared from the following raw materials in percentage by mass: 5-10% of butanediol, 1-5% of glycerol, 2-10% of active substance, 0.05-0.20% of xanthan gum, 0.01-0.1% of sodium hyaluronate, 0.5-2% of 1, 2-hexanediol, 0.05-0.5% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.05-0.5% of pH regulator, 0.3-0.6% of p-hydroxyacetophenone and the balance of deionized water.
The active matter is a combination of a beta-cyclodextrin coffee extract 50% compound, phytoglycogen, a magnolia biondii extract and a 25ppm glycerol solution of palmitoyl tripeptide-5, wherein the mass ratio of the beta-cyclodextrin coffee extract 50% compound, the phytoglycogen, the magnolia biondii extract and the 25ppm glycerol solution of palmitoyl tripeptide-5 is 0.5-5: 0.1-2: 0.5-1: 0.5-5.
The preparation method of the hope spring flower extract comprises the following steps: crushing the dried flower buds of the hope spring flowers, adding deionized water according to the material-liquid ratio of 10:1, heating in a water bath at 80 ℃ for 1 hour, filtering, and collecting an extracting solution, or further comprising: adding the same amount of deionized water into the filter residue, repeating the water bath heating, filtering and collecting the extract; filtering all the obtained extracting solutions by adopting a 0.45-micron filter membrane, adding glycerol, p-hydroxyacetophenone and 1, 2-hexanediol to form a mixture, wherein the mass percent of the glycerol, the mass percent of the p-hydroxyacetophenone and the mass percent of the 1, 2-hexanediol in the mixture are respectively 10%, 0.5% and 0.7%, and the mixture is the gomphrena globosa extract.
The preparation method of the beta-cyclodextrin coffee extract 50% compound comprises the following steps: crushing coffee beans, putting the crushed coffee beans into a filter paper sleeve of a Soxhlet extractor, and then putting the crushed coffee beans into a 250ml round-bottom flask according to the material-liquid ratio of 1.2:1, adding 95 percent ethanol and a plurality of grains of zeolite, and heating in a water bath; continuously extracting for 2.5-3.0h, stopping heating after the reflux liquid is colorless, evaporating to concentrate the extract, pouring into an evaporating dish while hot, adding appropriate amount of ground calcium oxide, heating with alcohol lamp and asbestos gauze, steaming, baking thoroughly, cooling, wiping off the powder on the evaporating dish, heating with sand bath for sublimation, and collecting to obtain white powder; then adding beta-cyclodextrin into a small amount of water, heating to 50 ℃, stirring and dissolving to obtain a transparent liquid, dissolving the collected white powder by using a small amount of ethanol, dropwise adding the dissolved beta-cyclodextrin into the solution, keeping the temperature and stirring for 2 hours, cooling and freezing for 24 hours, filtering, washing by using deionized water, and drying; finally, the compound with 50 percent of the needed beta-cyclodextrin coffee extract is obtained.
The preparation method of the phytoglycogen comprises the following steps: weighing sweet corn kernels, grinding the sweet corn kernels into paste by using a mortar, adding deionized water according to the material-liquid ratio of 1:5, grinding the mixture into pulp by using a pulping machine, and transferring the pulp into a beaker; extracting with water at 8 deg.C for 8 hr, and standing in refrigerator for a certain time; centrifuging at 12000rad at 4 deg.C for 30min, mixing the supernatants, adjusting pH to 4.9 with 0.1mmol/L hydrochloric acid, standing in refrigerator for 2h, suction filtering, adjusting filtrate to 7.0 with 0.1mmol/L sodium hydroxide, boiling for 30min, standing for a period of time, suction filtering, adding 3 times of anhydrous ethanol into the filtrate, standing in refrigerator, suction filtering to obtain filter cake, drying, and grinding into powder to obtain phytoglycogen.
The preparation method of the anti-aging and repairing essence liquid comprises the following steps:
s1, mixing glycerol, xanthan gum and sodium hyaluronate uniformly in advance for later use;
s2, preheating butanediol and p-hydroxyacetophenone to 70 ℃, stirring and dissolving for later use;
s3, adding deionized water into a stirring pot, scattering acrylate/C10-30 alkanol acrylate cross-linked polymer powder into the pot under stirring, starting to heat up, adding the material obtained in the step S1 into the stirring pot, stirring and heating to 85 ℃, keeping the temperature for 30 minutes, starting to cool, cooling to 45 ℃, sequentially adding the material obtained in the step S2, a pH regulator, a 50% compound of a beta-cyclodextrin coffee extract, phytoglycogen, a magnolia biondii extract, a glycerol solution of 25ppm palmitoyl tripeptide-5 and 1, 2-hexanediol under stirring, and uniformly stirring;
s4, cooling to room temperature, standing and checking;
and S5, checking to be qualified, filtering by a 200-mesh sieve and discharging.
The pure anti-aging repairing liquid is used independently, or used for preparing anti-aging repairing essence milk or anti-aging repairing cream, or skin care products in other formulations.
In the anti-aging repair essence emulsion or the anti-aging repair cream, the addition amount of the anti-aging repair essence liquid is 5-10% by mass.
In the anti-aging and repairing essence liquid, 50 percent of compounds of the beta-cyclodextrin coffee extract are rich in caffeine, so that the anti-aging and repairing essence liquid has a strong anti-oxidation characteristic, protects cells from ultraviolet radiation, protects fibroblasts, slows down the skin photoaging process, stimulates cell metabolism and accelerates local microcirculation; phytoglycogen increases cell growth and the production of endogenous collagen and hyaluronic acid, can effectively promote autohydration, acts synergistically with HA, and significantly reduces fine lines and wrinkles; the magnolia biondii pamp extract has the effect of local convergence, can effectively tighten the skin, has obvious anti-wrinkle effect, can inhibit the activity of tyrosinase, and can reduce the deposition of melanin; the activation of TGF- β by palmitoyl tripeptide-5 stimulates collagen synthesis in fibroblasts and protects collagen in keratinocytes. The four ingredients have the combined action of resisting oxidation, reducing the generation of free radicals, replenishing water, moisturizing and firming skin, promoting the production of collagen and hyaluronic acid, and effectively resisting aging, repairing and protecting skin.
The experimental result shows that the best use effect can be obtained by matching the four active substances. The product has the advantages of natural property, no irritation, obvious and durable anti-aging repairing effect, and the like.
The refined liquid is water-soluble substances and does not contain oil, compared with the general formulation product, the formula is more simplified, no more auxiliary materials are added, no components harmful to skin such as essence, pigment or mineral oil are added, the use is safe, and no burden is caused.
In summary, the invention extracts and screens active ingredients in various plants with anti-aging and repairing effects, converts the obtained plant functional ingredients into water-soluble substances, and combines the water-soluble substances with polypeptides to form a pure solution with anti-aging and repairing effects and provides a preparation method thereof.
Detailed Description
The present invention will be further described with reference to the following examples. It is to be understood that the following examples are illustrative only and are not intended to limit the scope of the invention, which is to be given numerous insubstantial modifications and adaptations by those skilled in the art based on the teachings set forth above.
Example 1: (product 8)
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 2.0% of a beta-cyclodextrin coffee extract 50% complex, 1.5% of a glycerol solution of 25ppm palmitoyl tripeptide-5, 0.5% of phytoglycogen, 1.0% of a magnolia biondii extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of a pH regulator and the balance of deionized water.
The preparation method of the anti-aging and repairing essence liquid comprises the following steps:
(1) mixing glycerol, xanthan gum and sodium hyaluronate uniformly in advance for later use;
(2) preheating butanediol and p-hydroxyacetophenone to 70 ℃, stirring and dissolving for later use;
(3) adding deionized water into a stirring pot, scattering acrylate/C10-30 alkanol acrylate cross-linked polymer powder into the pot under stirring, starting to heat up, adding the material obtained in the step (1) into the stirring pot, stirring and heating to 85 ℃, preserving heat for 30 minutes, starting to cool, cooling to 45 ℃, sequentially adding the material obtained in the step (2), a pH regulator, a 50% compound of a beta-cyclodextrin coffee extract, phytoglycogen, a magnolia biondii extract, a glycerol solution of 25ppm palmitoyl tripeptide-5 and 1, 2-hexanediol under stirring, and uniformly stirring;
(4) cooling to room temperature, standing, and inspecting;
(5) and (5) passing the inspection, filtering by 200 meshes and discharging.
The preparation method of the hope spring flower extract comprises the following steps: crushing the dried flower buds of the hope spring flowers, adding deionized water according to the material-liquid ratio of 10:1, heating in a water bath at 80 ℃ for 1 hour, filtering, collecting an extracting solution, adding the same deionized water into filter residues, repeating the operation, combining the obtained extracting solutions, filtering with a 0.45-micron filter membrane, adding 10% of glycerol, 0.5% of p-hydroxyacetophenone and 0.7% of 1, 2-hexanediol, and obtaining the hope spring flower extracting solution.
The preparation method of the beta-cyclodextrin coffee extract 50% compound comprises the following steps: pulverizing coffee bean, placing into filter paper sleeve of Soxhlet extractor, adding 95% ethanol and several grains of zeolite into 250ml round bottom flask at a ratio of 1.2:1, and heating in water bath. Continuously extracting for 2.5-3.0 hr, stopping heating after the reflux liquid is colorless, evaporating to concentrate the extractive solution, pouring into an evaporating dish while it is hot, adding appropriate amount of ground calcium oxide, heating with alcohol lamp and asbestos gauze, steaming, baking thoroughly, cooling, wiping off the powder on the evaporating dish, heating with sand bath for sublimation, and collecting to obtain white powder. And then adding beta-cyclodextrin into a small amount of water, heating to 50 ℃, stirring and dissolving to obtain a transparent liquid, dissolving the collected white powder by using a small amount of ethanol, dropwise adding the dissolved beta-cyclodextrin into the solution, keeping the temperature and stirring for 2 hours, cooling and freezing for 24 hours, filtering, washing with deionized water, and drying. Finally, the compound with 50 percent of the needed beta-cyclodextrin coffee extract is obtained.
The preparation method of the phytoglycogen comprises the following steps: weighing sweet corn kernels, grinding the sweet corn kernels into paste by using a mortar, adding deionized water according to the material-liquid ratio of 1:5, grinding the mixture into pulp by using a pulping machine, and transferring the pulp into a beaker. Performing water extraction at the temperature of 8 ℃ for 8h, then placing the mixture into a refrigerator for standing for a period of time, centrifuging the mixture for 30min at 12000rad at the temperature of 4 ℃, combining supernate, adjusting the pH to 4.9 by using 0.1mmol/L hydrochloric acid, then placing the mixture into the refrigerator for 2h, performing suction filtration, adjusting the filtrate to 7.0 by using 0.1mmol/L sodium hydroxide, boiling the mixture for 30min, then placing the mixture into the refrigerator for suction filtration for a period of time, adding 3 times of absolute ethyl alcohol into the filtrate, placing the filtrate into the refrigerator for suction filtration to obtain a filter cake, drying the filter cake, and grinding the dried filter cake into powder to obtain the phytoglycogen.
Example 2: (product 9)
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 3.0% of a beta-cyclodextrin coffee extract 50% complex, 3.0% of a 25ppm glycerol solution of palmitoyl tripeptide-5, 1.0% of phytoglycogen, 1.0% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of a pH regulator and the balance of deionized water.
The preparation method is the same as example 1.
Example 3
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 2.0% of a beta-cyclodextrin coffee extract 50% complex, 2.5% of a glycerol solution of 25ppm of palmitoyl tripeptide-5, 0.1% of phytoglycogen, 0.5% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of a pH regulator and the balance of deionized water.
The anti-aging repairing essence of this example was prepared in the same manner as in example 1.
Example 4
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 2.0% of a beta-cyclodextrin coffee extract 50% complex, 2.5% of a glycerol solution of 25ppm of palmitoyl tripeptide-5, 0.5% of phytoglycogen, 0.5% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate crosspolymer, 0.15% of a pH regulator and the balance of deionized water.
The anti-aging repairing essence of this example was prepared in the same manner as in example 1.
Example 5
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 0.5% of a beta-cyclodextrin coffee extract 50% complex, 0.5% of a 25ppm glycerol solution of palmitoyl tripeptide-5, 0.1% of phytoglycogen, 0.5% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of a pH regulator and the balance of deionized water.
The anti-aging repairing essence of this example was prepared in the same manner as in example 1.
Example 6
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 1.5% of a beta-cyclodextrin coffee extract 50% complex, 0.5% of a glycerol solution of 25ppm palmitoyl tripeptide-5, 0.1% of phytoglycogen, 0.5% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of a pH regulator and the balance of deionized water.
The anti-aging repairing essence of this example was prepared in the same manner as in example 1.
Example 7
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 3.0% of a beta-cyclodextrin coffee extract 50% complex, 4.0% of a 25ppm glycerol solution of palmitoyl tripeptide-5, 1.5% of phytoglycogen, 1.0% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.4% of phenoxyethanol, 0.10% of ethylhexyl glycerol and the balance of deionized water.
The anti-aging repairing essence of this example was prepared in the same manner as in example 1.
Example 8
The anti-aging repairing pure liquid of the embodiment comprises the following components in percentage by weight: 6.4% of butanediol, 3.5% of glycerol, 2.0% of a beta-cyclodextrin coffee extract 50% complex, 5.0% of a glycerol solution of 25ppm of palmitoyl tripeptide-5, 2.0% of phytoglycogen, 1.0% of a magnolia biondii flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate crosspolymer, 0.15% of a pH regulator and the balance of deionized water.
The anti-aging repairing essence of this example was prepared in the same manner as in example 1.
Example 9 (product 11)
The base milk formula was prepared as follows:
the preparation process of the skin soothing and repairing essence milk comprises the following steps:
(1) firstly, weighing the raw materials according to the names and the weights of the raw materials in the table;
(2) heating the phase A four raw materials to 85 ℃, and stirring until the phase A four raw materials are completely dissolved;
(3) heating the six raw materials of the phase B to 75 ℃, and stirring until the raw materials are completely dissolved;
(4) adding A, B phase, stirring, and homogenizing at high speed for 4 min. Cooling to 45 deg.C under stirring, adding phase C, stirring, and cooling to room temperature to obtain the final product.
Comparative example 1 (product 1):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 4.0% of beta-cyclodextrin coffee extract 50% compound, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of pH regulator and the balance of deionized water.
Comparative example 2 (product 2):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 4.0% of 25ppm of a glycerol solution of palmitoyl tripeptide-5, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of pH regulator and the balance of deionized water.
Comparative example 3 (product 3):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 4.0% of phytoglycogen, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of pH regulator and the balance of deionized water.
Comparative example 4 (product 4):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 4.0% of a gomphrena flower extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of pH regulator and the balance of deionized water.
Comparative example 5 (product 5):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 2.0% of a beta-cyclodextrin coffee extract 50% compound, 2.0% of a 25ppm glycerol solution of palmitoyl tripeptide-5, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of pH regulator and the balance of deionized water.
Comparative example 6 (product 6):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 2.0% of beta-cyclodextrin coffee extract 50% compound, 2.0% of gomphrena flos extract, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of pH regulator and the balance of deionized water.
Comparative example 7 (product 7):
the anti-aging repairing pure liquid of the comparative example comprises the following components in percentage by weight:
6.4% of butanediol, 3.5% of glycerol, 1.5% of a beta-cyclodextrin coffee extract 50% compound, 1.5% of a gomphrena flos extract, 1.0% of a 25ppm glycerol solution of palmitoyl tripeptide-5, 0.5% of xanthan gum, 0.06% of sodium hyaluronate, 0.5% of p-hydroxyacetophenone, 0.5% of 1, 2-hexanediol, 0.15% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.15% of a pH regulator and the balance of deionized water.
COMPARATIVE EXAMPLE 8 (product 10)
A base milk was prepared with the following formulation:
the preparation process of the skin soothing and repairing essence milk comprises the following steps:
(1) firstly, weighing the raw materials according to the names and the weights of the raw materials in the table;
(2) heating the phase A four raw materials to 85 ℃, and stirring until the phase A four raw materials are completely dissolved;
(3) heating the six raw materials of the phase B to 75 ℃, and stirring until the raw materials are completely dissolved;
(4) adding A, B phase, stirring, and homogenizing at high speed for 4 min. Cooling to 45 deg.C under stirring, adding phase C, stirring, and cooling to room temperature to obtain the final product.
(5) Subpackaging to obtain the finished product.
The product using method comprises the following steps: after cleaning the skin in the morning and evening, a proper amount of the product is taken and applied to the face for massaging, so that the effect is better. After absorption, other skin care products can be used.
The anti-aging repair essence solutions prepared in comparative examples 1-7 and examples 1-2 were compared with the existing anti-aging essence after being subjected to volunteer trial for six weeks, and the emulsions prepared in comparative example 8 and example 9 were compared after being subjected to volunteer trial for six weeks.
The experimental results are shown in the following table:
the experiments show that the anti-aging repairing pure liquid has faster and more lasting effect, and can play a certain role in anti-aging repairing when being added into cream. Among different active substances, phytoglycogen and 25ppm of palmitoyl tripeptide-5 in glycerol solution have better repairing and wrinkle removing effects, but the beta-cyclodextrin coffee extract 50% compound and the magnolia biondii extract have good effects of resisting oxidation and firming skin. The four are combined for use, so that the effect is more obvious.
The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. The pure anti-aging and repairing liquid is characterized by comprising the following components in parts by weight: the composite material is prepared from the following raw materials in percentage by mass: 5-10% of butanediol, 1-5% of glycerol, 2-10% of active substance, 0.05-0.20% of xanthan gum, 0.01-0.1% of sodium hyaluronate, 0.5-2% of 1, 2-hexanediol, 0.05-0.5% of acrylate/C10-30 alkanol acrylate cross-linked polymer, 0.05-0.5% of pH regulator, 0.3-0.6% of p-hydroxyacetophenone and the balance of deionized water.
2. A rejuvenating liquid for anti-aging according to claim 1, wherein: the active matter is a combination of a beta-cyclodextrin coffee extract 50% compound, phytoglycogen, a magnolia biondii extract and a 25ppm glycerol solution of palmitoyl tripeptide-5, wherein the mass ratio of the beta-cyclodextrin coffee extract 50% compound, the phytoglycogen, the magnolia biondii extract and the 25ppm glycerol solution of palmitoyl tripeptide-5 is 0.5-5: 0.1-2: 0.5-1: 0.5-5.
3. A rejuvenating liquid for anti-aging according to claim 2, wherein: the preparation method of the hope spring flower extract comprises the following steps: crushing the dried flower buds of the hope spring flowers, adding deionized water according to the material-liquid ratio of 10:1, heating in a water bath at 80 ℃ for 1 hour, filtering, and collecting an extracting solution, or further comprising: adding the same amount of deionized water into the filter residue, repeating the water bath heating, filtering and collecting the extract; filtering all the obtained extracting solutions by adopting a 0.45-micron filter membrane, adding glycerol, p-hydroxyacetophenone and 1, 2-hexanediol to form a mixture, wherein the mass percent of the glycerol, the mass percent of the p-hydroxyacetophenone and the mass percent of the 1, 2-hexanediol in the mixture are respectively 10%, 0.5% and 0.7%, and the mixture is the gomphrena globosa extract.
4. A rejuvenating liquid for anti-aging according to claim 2, wherein: the preparation method of the beta-cyclodextrin coffee extract 50% compound comprises the following steps: crushing coffee beans, putting the crushed coffee beans into a filter paper sleeve of a Soxhlet extractor, and then putting the crushed coffee beans into a 250ml round-bottom flask according to the material-liquid ratio of 1.2:1, adding 95 percent ethanol and a plurality of grains of zeolite, and heating in a water bath; continuously extracting for 2.5-3.0h, stopping heating after the reflux liquid is colorless, evaporating to concentrate the extract, pouring into an evaporating dish while hot, adding appropriate amount of ground calcium oxide, heating with alcohol lamp and asbestos gauze, steaming, baking thoroughly, cooling, wiping off the powder on the evaporating dish, heating with sand bath for sublimation, and collecting to obtain white powder; then adding beta-cyclodextrin into a small amount of water, heating to 50 ℃, stirring and dissolving to obtain a transparent liquid, dissolving the collected white powder by using a small amount of ethanol, dropwise adding the dissolved beta-cyclodextrin into the solution, keeping the temperature and stirring for 2 hours, cooling and freezing for 24 hours, filtering, washing by using deionized water, and drying; finally, the compound with 50 percent of the needed beta-cyclodextrin coffee extract is obtained.
5. A rejuvenating liquid for anti-aging according to claim 2, wherein: the preparation method of the phytoglycogen comprises the following steps: weighing sweet corn kernels, grinding the sweet corn kernels into paste by using a mortar, adding deionized water according to the material-liquid ratio of 1:5, grinding the mixture into pulp by using a pulping machine, and transferring the pulp into a beaker; extracting with water at 8 deg.C for 8 hr, and standing in refrigerator for a certain time; centrifuging at 12000rad at 4 deg.C for 30min, mixing the supernatants, adjusting pH to 4.9 with 0.1mmol/L hydrochloric acid, standing in refrigerator for 2h, suction filtering, adjusting filtrate to 7.0 with 0.1mmol/L sodium hydroxide, boiling for 30min, standing for a period of time, suction filtering, adding 3 times of anhydrous ethanol into the filtrate, standing in refrigerator, suction filtering to obtain filter cake, drying, and grinding into powder to obtain phytoglycogen.
6. A method for preparing an anti-aging and repairing pure liquid as claimed in any one of claims 1 to 5, which comprises the following steps:
s1, mixing glycerol, xanthan gum and sodium hyaluronate uniformly in advance for later use;
s2, preheating butanediol and p-hydroxyacetophenone to 70 ℃, stirring and dissolving for later use;
s3, adding deionized water into a stirring pot, scattering acrylate/C10-30 alkanol acrylate cross-linked polymer powder into the pot under stirring, starting to heat up, adding the material obtained in the step S1 into the stirring pot, stirring and heating to 85 ℃, keeping the temperature for 30 minutes, starting to cool, cooling to 45 ℃, sequentially adding the material obtained in the step S2, a pH regulator, a 50% compound of a beta-cyclodextrin coffee extract, phytoglycogen, a magnolia biondii extract, a glycerol solution of 25ppm palmitoyl tripeptide-5 and 1, 2-hexanediol under stirring, and uniformly stirring;
s4, cooling to room temperature, standing and checking;
and S5, checking to be qualified, filtering by a 200-mesh sieve and discharging.
7. The method of using an anti-aging remedial fluid of any of claims 1-6, wherein: the pure anti-aging repairing liquid is used alone or used for preparing anti-aging repairing essence milk or anti-aging repairing cream.
8. The use of an anti-aging remedial fluid according to claim 7, wherein: in the anti-aging repair essence emulsion or the anti-aging repair cream, the addition amount of the anti-aging repair essence liquid is 5-10% by mass.
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| CN114306200A (en) * | 2021-11-05 | 2022-04-12 | 仙婷(广州)科技研发有限公司 | Anti-aging repairing composition and application thereof |
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