KR102168532B1 - Cosmetic composition for enhancing skin elasticity or improving skin wrinkle containing herb extracts - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving skin elasticity or wrinkles comprising an herbal extract, and more particularly, one or more extracts selected from the group consisting of angelica, cornus, deer antler and sun thyme as an active ingredient. It relates to a cosmetic composition for improving skin elasticity or wrinkles, including.

Description

Cosmetic composition for enhancing skin elasticity or improving skin wrinkle containing herb extracts, including herbal extracts

The present invention relates to a cosmetic composition for improving skin elasticity or wrinkles comprising an herbal extract, and more specifically, one or more extracts selected from the group consisting of angelica, cornus, antler and sun thyme as an active ingredient. It relates to a cosmetic composition for improving skin elasticity or wrinkles, including.

Collagen, a major component of the extracellular matrix, is a major matrix protein produced by fibroblasts in the skin. In addition, it is an important protein that accounts for about 30% of the total weight of the biological protein, and has a rigid triple helix structure. Collagen forms most of the organic matter in skin, tendons, bones and teeth, especially in bones and skin (ground skin). It exists as a fibrous inclusion body in most other body structures.

Collagen is a relatively weak immunogen, partly due to the shielding of latent antigenic determinants by the helix of collagen, and this helix also makes collagen resistant to protein degradation. The main functions of collagen are known for its mechanical firmness, connective tissue resistance and tissue bonding, support for cell adhesion, and induction of cell division and differentiation (at the time of organic growth or wound healing) (Non-Patent Document 1). .

Such collagen decreases due to age and photoaging due to ultraviolet irradiation, which is known to be closely related to the formation of wrinkles in the skin (Non-Patent Document 2). In addition, collagen plays an important role in wound healing, and by promoting the synthesis of collagen in the damaged epithelium, wounds can be recovered quickly and without scarring.

Conventionally, in order to take advantage of the skin moisturizing effect and wound healing effect of collagen, products containing collagen in external skin preparations such as cosmetics or ointments have been released, but these products apply collagen itself to the skin surface, and are a polymer substance called collagen. It could not be said that it shows essential skin function improvement and wound healing function because it cannot be expected to have a moisturizing effect or wound healing effect due to its difficulty in transdermal absorption.

In order to solve this problem, interest in collagen synthesis promoting substances has increased, and conventionally known collagen synthesis promoting substances include vitamin C, retinoic acid, carcinogenic growth factor (Non-Patent Document 3), and animal placenta-derived substances. Protein (Patent Document 1), betulinic acid (Patent Document 2), chlorella extract (Patent Documents 3 and 4), and the like.

However, when these substances are applied to the skin, the amount of use of these substances is limited due to safety problems such as irritation and redness, or the effect is insignificant, so that the effect of substantially improving skin function or wound healing could not be expected. Accordingly, there is an urgent need to develop a new composition for external application for skin that is safer and more effective than the existing composition for external application for skin.

Under this background, the present inventors have conducted research on substances that are not toxic from natural resources and have excellent skin condition improvement effect, and thus at least one selected from the group consisting of angelica, cornus, antler and thyme It was found that the herbal medicine extract showed the effect of increasing the total amount of collagen, and a cosmetic composition for improving skin elasticity or wrinkles was completed using this.

Japanese Laid-Open Patent Publication No. Hei 8-231370 Japanese Laid-Open Patent Publication No. Hei 8-208424 Japanese Published Patent Publication No. Hei 9-40526 Japanese Laid-Open Patent Publication No. Hei 10-36283

Van der Rest et al., Ann. NY Acad. Sci., 1990, 580:8-16. Arthur K. Balin et al., Aging and the skin, 1989 Cardinale G. et al., Adv. Enzymol., 1974, 41, 245-300

It is an object of the present invention to provide a cosmetic composition for improving skin elasticity or wrinkles, characterized in that it comprises one or more extracts selected from the group consisting of angelica angelica, cornus milk, antler and sun thyme as an active ingredient.

In order to solve the above problem, as an embodiment of the present invention, as an active ingredient, skin elasticity enhancement or a fraction thereof comprising one or more extracts selected from the group consisting of angelfish, cornus milk, antler and sun thyme It provides a cosmetic composition for improving wrinkles.

In another embodiment of the present invention, it provides a cosmetic composition for improving skin elasticity or wrinkles, characterized in that it comprises a mixed extract or a fraction thereof of an angelfish, cornus milk, antler and sun thyme as an active ingredient.

In another embodiment of the present invention, the mixing ratio of the angelfish, cornus milk, antler and thyme is 10 to 40: 10 to 40: 10 to 40: 10 to 40, more preferably 20 to 30: 20 by weight. To 30: 20 to 30: it may be 20 to 30.

Angelica acutiloba of the present invention is a dried root of Daehwa Angelica, a perennial herb belonging to the Parsley family, and is also called Japanese Angelica, and its taste is sweet and very, and its nature is warm. Ildangwi was first introduced and cultivated for export to Japan, but in recent years, it has been in the spotlight as a functional ssam vegetable with its unique fragrance and rich minerals and vitamins reported on its leaves. In terms of efficacy, useful pharmacological effects such as neuroprotective effects, analgesics, and anti-inflammatory effects are known.

Corni Fructus of the present invention belongs to the dogwood family, and when the fruit matures in October to November, it is collected, removed branches and stems, dried over low heat, cooled, and discarded, the seeds are discarded, and the pulp is dried again in sunlight or low heat, and shade Keep in. In oriental medicine, it is used as a nutrient, tonic, and astringent medicine, and the main ingredients are Moroniside, Loganin, Cornin (Verbenalin), Saponin, Tannin, and ursolic acid. (Ursolic acid), gallic acid (Gallic acid), mariic acid (Malic acid), tartaric acid (Tartaric acid) and vitamin A, etc. are contained.

The antler (cervi parvum cornu) of the present invention is a herbal medicine that has been widely used as a blood tonic for a long time as a dried herbal medicine obtained by collecting and processing freshly grown horns of a stag. As a result of animal and clinical trials, deer antler was found to have an effect of promoting growth and development in children, an anti-aging effect, an effect of hematopoietic function, an effect of improving heart function, an anti-muscular fatigue effect, and an anti-pain effect.

The thyme of the present invention (Thymus vulgaris) is a perennial evergreen tree that grows to about 45cm and has many branches. The leaves are grayish green and have an aromatic scent, and the flowers are pale purple or white. It is mainly used for respiratory and digestive problems, and the British Herbal Pharmacopoeia says that it can be used for indigestion, chronic gastritis, and bronchitis.

As used in the present invention, the term "extract" refers to an extract obtained by extraction treatment of the Angelica Angelica, Cornus deer antler, Sun thyme or a mixture thereof, a dilution or concentrate of the extract, a dried product obtained by drying the extract, and It includes the extract of all formulations that can be formed using the extract itself and the extract, such as a crude product, a purified product, or a mixture thereof.

The extract of the present invention may be extracted from natural, hybrid or variant plants of the respective plants, and may be extracted from plant tissue culture.

In the extraction of the angelfish, cornus, antler, thyme or a mixture thereof of the present invention, the extraction method is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include a hot water extraction method, an ultrasonic extraction method, a filtration method, a reflux extraction method, and the like, which may be performed alone or in combination of two or more methods.

In the present invention, the kind of the extraction solvent used to extract the mono angelica, cornus oil, antler, thyme or a mixture thereof is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water; C ₁ to C ₄ lower alcohols such as methanol, ethanol, propyl alcohol, and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol, and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof may be used, and preferably, water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in combination of two or more. In the present invention, more preferably, water (or distilled water), 1,3-butylene glycol, or a mixed solvent thereof may be used as a solvent for extracting herbal medicinal herbs such as Angelicae, Cornus oil, Deer antler, and Sun thyme. Using the solvent, a solvent extract can be prepared by extracting medicinal herbs such as Angelicae, Cornus, antler, and Seon thyme at least once, and a dry extract obtained by distilling the solvent extract under reduced pressure and then freeze drying or spray drying can be prepared. have. In a specific embodiment of the present invention, a monosaccharide extract using an extraction solvent (distilled water: 1,3-butylene glycol = 7:3); Cornus extract; Antler extract; Sun thyme extract and mixed extracts of Japanese angelica, cornus, antler and sun thyme were prepared (Examples 1 to 5).

In the present invention, the extract extracted with hot water or cold needle is filtered to remove floating solid particles, for example, nylon, etc. to filter the particles, or after filtration using a freeze filtration method, etc., or use as such, or freeze drying, hot air drying, It can be used after drying by spray drying or the like.

As used herein, the term "fraction" means a result obtained by performing fractionation in order to separate a specific component or a specific component group from a mixture containing several different constituents.

The fractionation method for obtaining the fraction in the present invention is not particularly limited, and may be performed according to a method commonly used in the art. Non-limiting examples of the fractionation method may include a method of obtaining a fraction from the extract by treating an extract obtained by extracting Angelicae, Cornus, antler, Sun thyme, or a mixture thereof with a predetermined solvent.

In the present invention, the type of solvent used to obtain the fraction is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the fractionation solvent include polar solvents such as water and alcohol; Non-polar solvents, such as hexane (Hexane), ethyl acetate (Ethyl acetate), chloroform (Chloroform), and dichloromethane (Dichloromethane), etc. are mentioned. These may be used alone or in combination of two or more. In the case of using an alcohol in the fractionation solvent, preferably a C ₁ to C ₄ alcohol may be used.

The Angelicae extract, Cornus extract, Deer antler extract, Sun thyme extract or the mixed extract of Angelicae, Cornus, deer antler and Sun thyme of the present invention effectively promotes collagen synthesis, thereby enhancing skin elasticity and improving wrinkles. In addition, since the composition of the present invention is a material derived from a natural product, it is not toxic, and even when applied to the human body, side effects are not caused, so it can be used as a cosmetic composition.

The term "collagen" used in the present invention is a protein that occupies the largest part quantitatively and functionally in the human body, an extracellular matrix that forms the skeleton of all cells in the human body, more specifically connective tissue (connective tissue). tissue) refers to the major constituent factor. Human tissues containing a large amount of collagen include skin, bone tissues such as bone and cartilage, tendons, ligaments, and the like. Due to the aging of the tissues, human aging diseases such as skin wrinkles and sagging and osteoporosis are caused, which is known to be due to a decrease in the amount and function of collagen in the body due to a decrease in collagen synthesis in the tissue.

On the other hand, the main function of skin fibroblasts is the regeneration of damaged skin tissues through the synthesis and proliferation of extracellular matrix.Exogenous aging factors such as photoaging or damage accumulation due to free oxygen, endogenous due to cell aging due to telomere breakage, etc. The aging factors reduce the physiological activity of the skin fibroblasts in the dermal layer. Type I collagen, which accounts for more than 95% of the skin's extracellular matrix, and plays a very important part in the physiological activity of fibroblasts through interaction and signal exchange with cell adhesion molecules and cytoskeletons. When the synthesis of is decreased, the amount of collagen in the skin tissue decreases, and thus the surface tension decreases to form skin wrinkles, as well as the cause of a vicious cycle in which physiologically active functions including proliferation and regeneration functions of cells decrease do. Therefore, it can be seen that collagen of skin fibroblasts is directly related to skin aging, skin wrinkle formation, and tissue repair or regeneration in case of skin damage.

That is, when the synthesis of collagen or procollagen of skin fibroblasts is promoted, it is possible to prevent and improve skin wrinkles, heal wounds, repair and regenerate damaged skin tissue, and prevent and improve skin aging.

Specifically, in one embodiment of the present invention, in the case of using Angelicae extract, Cornus oil extract, Deer antler extract, Sun thyme extract or mixed extract of Angelicae, Cornus oil, deer antler and Sun thyme, respectively, human-derived fibroblasts compared to using the basic medium. It was confirmed that the amount of collagen production was increased in (Example 6).

In particular, the extract of the mixture containing all of the Angelicae, Cornus, deer antler and Sun thyme of the present invention or a fraction thereof is a single extract of each plant by synergistic or cooperative action between the extracts and/or the active ingredients in the extract Compared to vitamin C, which is a known collagen synthesis promoting substance, considering that it has a more excellent ability to promote collagen synthesis than that, it was confirmed that there is a very strong ability to promote collagen synthesis, which is equivalent to or higher in fibroblasts. It was first identified in.

Specifically, the extract of the mixture containing all of the Angelicae, Cornus, Deer antler and Sun thyme of the present invention, or a fraction thereof, further increases the amount of collagen production compared to the single extract of Angelicae, Cornus, Antler, or Sun Thyme, resulting in better skin elasticity. It may exhibit an enhancement or wrinkle improvement effect.

In the present invention, the mixing ratio of the angelica, cornus, antler and thyme is preferably 10 to 40: 10 to 40: 10 to 40: 10 to 40, more preferably 20 to 30: 20 to 30 by weight. : 20 to 30: It may be 20 to 30.

According to a specific embodiment of the present invention, as a result of examining the degree of increase in the total amount of collagen, the degree of increase in the total amount of collagen thereof was investigated by preparing a mixed extract having a mixture ratio of the angel angelfish, cornus milk, antler and thyme in 25:25:25:25. It was found to be larger compared to the single extract of the angelfish, cornus, antler or thyme (Example 6).

The term "skin elasticity" used in the present invention is expressed by elastic fibers composed of elastin present in the dermal layer. These elastic fibers have a very low modulus of elasticity like rubber, so they are easily deformed even by a small force. Also, when the force is removed, it easily returns to its original shape. In addition, elastic fibers have a form in which microfibrils are embedded in an amorphous substrate called elastin, and elastin is a very sticky fiber found only in elastic fibers called desmosine and isodesmosine derived from lysine. It is a protein composed of one amino acid. These desmosin and isodesmosin form cross-links in a long peptide chain, and this structure gives elastin a rubber-like property.

The term "skin elasticity enhancement" used in the present invention means that elastic fibers composed of elastin exist together with collagen fibers called collagen, and the elasticity of the skin is maintained or increased in a state in which elastin and collagen are sufficiently present. .

As used herein, the term "skin wrinkles" refers to fine lines caused by deterioration of the skin, and may be caused by genes, reduction of collagen and elastin present in the skin dermis, external environment, and the like.

As used herein, the term "skin wrinkle improvement" refers to inhibiting or inhibiting the generation of wrinkles on the skin, or alleviating wrinkles that have already been created.

The cosmetic composition of the present invention is a solution, external ointment, cream, foam, nutrient lotion, flexible lotion, pack, softening water, emulsion, makeup base, essence, soap, liquid detergent, bathing agent, sunscreen cream, sun oil, suspension, emulsion It can be prepared in a formulation selected from the group consisting of liquid, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch, and spray, but is limited thereto. no.

The cosmetic composition of the present invention may additionally include one or more cosmetically acceptable carriers blended in general skin cosmetics, and as common ingredients, for example, oil, water, surfactants, moisturizers, lower alcohols, thickeners , A chelating agent, a colorant, a preservative, a fragrance, and the like may be appropriately blended, but are not limited thereto.

The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.

When the formulation of the present invention is an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc. May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohard It may include a propellant such as locarbon, propane/butane or dimethyl ether, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent may be used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil, and the like may be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used, but are not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a soap, an alkali metal salt of a fatty acid, a fatty acid hemiester salt, a fatty acid protein hydrolyzate, isethionate, a lanolin derivative, an aliphatic alcohol, vegetable oil, glycerol, sugar, etc. are used as a carrier component. It may be, but is not limited thereto. These may be used alone or in combination of two or more.

In the cosmetic composition of the present invention, the herbal extracts of Angelicae, Cornus, Deer antler, Sun thyme or a mixture thereof may be included in a dry weight, 0.0001 to 50% by weight of the total weight of the cosmetic composition, and more preferably 0.0005 It is preferably included in to 10% by weight. There is an advantage of exhibiting excellent skin elasticity enhancement or wrinkle improvement effect within the above range, and there is an advantage that the formulation of the composition is stabilized.

The composition containing an extract or a fraction thereof of an angelica root, cornus corn, antler, sun thyme or a mixture thereof of the present invention is excellent in enhancing skin elasticity or improving wrinkles. Specifically, the composition of the present invention has excellent efficacy in promoting collagen synthesis.

In addition, since the composition of the present invention is a material derived from a natural product, it is not toxic, and even when applied to the human body, it does not cause side effects, so its utilization as a cosmetic composition is high.

Hereinafter, the configuration and effects of the present invention will be described in more detail through examples. These examples are for illustrative purposes only, and the scope of the present invention is not limited by these examples.

Example One: Of the daily angelica extract Produce

After drying and slicing, 100 g of dry weight was added to a flask and extracted by cold soaking for 3 days with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 7:3). The cold-precipitated extract was filtered through a filter having a pore size of 0.2 µm to prepare a daily angelica extract.

Example 2: Preparation of Cornus oil extract

After drying and mincing the cornus oil, 100 g of dry weight was put into a flask and extracted by cold soaking for 3 days with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 7:3). The cold-precipitated extract was filtered through a filter having a pore size of 0.2 µm to prepare a cornus oil extract.

Example 3: Preparation of antler extract

After the antler was dried and minced, 100 g of dry weight was put into a flask, and extracted by cold soaking with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 7:3) for 3 days. The chilled extract was filtered through a filter having a pore size of 0.2 μm to prepare an antler extract.

Example 4: Sun thyme extract Produce

After drying and mincing the sun thyme, 100 g of dry weight was put into a flask, and extracted by cold soaking for 3 days with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 7:3). The chilled extract was filtered through a filter having a pore size of 0.2 μm to prepare a sun thyme extract.

Example 5: An angel , Cornus, antler and Thyme Preparation of mixed extract

After drying and slicing the angelica, cornus oil, antler and thyme, 100g of dry weight (25g of cornflower, 25g of cornus, 25g of deer antler, 25g of sun thyme) was added to the flask and extraction solvent (distilled water: 1,3-butylene glycol = 7 :3) 1000g was extracted by cold soaking for 3 days. The cold-precipitated extract was filtered through a filter having a pore size of 0.2 µm to prepare a mixed extract of Japanese angelfish, cornus milk, antler and sun thyme.

Example 6: Investigation of the effect of increasing the total amount of collagen

The extracts of Examples 1 to 5 were added to the culture medium of human-derived fibroblasts to test the effect of increasing the total amount of collagen by promoting collagen synthesis at the cellular level. Measurement of the total amount of increased collagen was quantified using PICP EIA kit (Procollagen Type I C-Peptide Enzyme ImmunoAssay KIT). Cytotoxicity evaluation by varying the concentration (% by weight) of the extract prepared in Example 1, Example 2, Example 3, Example 4, or Example 5 on human-derived fibroblasts before the experiment (cultivation of fibroblasts The MTT test was performed [Reference: Mossman T., Rapid Colorimetric Assay for Cellular Growth & SurvVIal: application to proliferation & cytotoxicity assays. Journal of Immunological Methods, 1983, 65, 55-63]), and cytotoxicity was No concentration was selected (1% or less) to evaluate the degree of increase in the total amount of collagen.

After each sample was added to the culture medium of human fibroblasts and cultured for 1 day, the culture solution was taken and the degree of increase in the total amount of collagen at each concentration was measured at 450 nm using a PICP EIA kit. For the comparison of the effects, the increase in the total amount of collagen was measured in the same manner for the culture medium of fibroblasts to which nothing was added (negative control) and the sample to which vitamin C was added to a final concentration of 52.8 μg/ ml (positive control). . The total amount of collagen was measured as UV absorbance, and the rate of increase of the total amount of collagen was calculated as the ratio of the relative total amount of collagen to the negative control, and the results are shown in Table 1 below. Also, the experiment was repeated 3 times.

sample(%) Absorbance average Collagen increase rate (%) Control (no addition) 456 - Vitamin C (52.8 ㎍/ml) 562 123 Example 1 (0.1%) 465 102 Example 1 (1.0%) 501 110 Example 2 (0.1%) 481 105 Example 2 (1.0%) 478 105 Example 3 (0.1%) 463 102 Example 3 (1.0%) 491 108 Example 4 (0.1%) 457 100 Example 4 (1.0%) 480 105 Example 5 (0.1%) 510 112 Example 5 (1.0%) 547 120

As can be seen from the results of Table 1, the daily Angelicae extract, cornus oil extract, antler extract, sun thyme extract, and mixed extracts of these herbal medicines have the effect of increasing the total amount of collagen by promoting collagen synthesis, and in particular, 4 kinds of herbal medicines are mixed. When extracted, it was found that there is an effect of increasing the total amount of collagen more significantly than that of each herbal extract alone, and it was confirmed that it increased the total amount of collagen as excellent as vitamin C, which is known to have collagen synthesis ability.

Manufacturing example 1: Preparation of essence containing the mixed extract of the present invention

A cosmetic composition of an essence formulation was prepared as shown in Table 2 below (unit: wt%).

Raw material name Content (% by weight) Cetearyl alcohol
Cetearyl glucoside
Jojoba seed oil
Silica
glycerin
Example 5 extract
Purified water 2
One
5
0.5
10
5
To 100

Manufacturing example 2: Preparation of a cream containing the mixed extract of the present invention

As shown in Table 3 below, a cream-formed cosmetic composition was prepared (unit: wt%).

Composition Content (% by weight) Example 5 extract
Stearic acid
ethanol
Potassium hydroxide
glycerin
Propylene glycol
antiseptic
incense
Purified water 5
15.0
1.0
0.7
5.0
3.0
Appropriate amount
Appropriate amount
to 100

Claims (7)

A cosmetic composition for improving skin elasticity or wrinkles, comprising an extract of sun thyme or a fraction thereof as an active ingredient.
The cosmetic composition for enhancing skin elasticity or wrinkles according to claim 1, comprising as an active ingredient a mixed extract of Japanese angelica, cornus milk, antler and sun thyme or a fraction thereof.
The cosmetic composition for enhancing skin elasticity or wrinkles according to claim 2, wherein the mixing ratio of the angelfish, cornus, antler and thyme is 10 to 40: 10 to 40: 10 to 40: 10 to 40 by weight. Composition.
The cosmetic composition for enhancing skin elasticity or wrinkles according to claim 3, wherein the mixing ratio of the angelica branch, cornus milk, antler and sun thyme is 25:25:25:25 based on weight.
The method of claim 1, wherein the extract is obtained by extracting Sun thyme with at least one solvent selected from the group consisting of water, C1 to C4 lower alcohol, 1,3-butylene glycol, and ethyl acetate. Cosmetic composition for improving skin elasticity or wrinkles.
The cosmetic composition of claim 5, wherein the solvent is a mixture of water and 1,3-butylene glycol in a weight ratio of 7:3.
The cosmetic composition for improving skin elasticity or wrinkles according to claim 1, wherein the skin elasticity enhancement or wrinkle improvement is achieved by promoting collagen synthesis.