CN109984952A - A kind of Essence and preparation method of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides - Google Patents
A kind of Essence and preparation method of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides Download PDFInfo
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- CN109984952A CN109984952A CN201711469999.4A CN201711469999A CN109984952A CN 109984952 A CN109984952 A CN 109984952A CN 201711469999 A CN201711469999 A CN 201711469999A CN 109984952 A CN109984952 A CN 109984952A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses the Essences and preparation method of a kind of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides, including the following raw material based on 100% weight percent: Sodium Hyaluronate 0.1-0.2；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2-0.3；Glycerol 5-7；1,3 butanediol 4-6；Dipeptides diaminobutyryl benzyl amide diacetin 0.3-0.5；- 5 0.2-0.3 of palmityl tetrapeptide；Palmityl tripeptides -10.3-0.5；- 4 0.3-0.5 of Matrixyl；Carnosine 0.1-0.3；Serine 0.1-0.3；Arginine 0.1-0.3；Niacinamide 0.1-0.3；The deionized water of preservative 0.2-0.3 and remaining ratio.The present invention repairs human skin using comprehensive, to reach good, quick removing wrinkle and resisting aging effect.
Description
Technical field
The present invention relates to a kind of skin-protection product, the Essence of especially a kind of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides
And preparation method.
Background technique
Everybody has a love of beauty, and particularly with the especially weight of skin for women, in life, clothes can have several people
Thousand sets, banknote can have several ten million, and face a lifetime only one, and old to change, having wrinkled cannot scald！Therefore skin is once
Relaxation aging, color spot is obscure, dry, small pox, and wearing again best bib and tucker also can not show that your taste makings, noble quality are proper,
The incompatible of oneself face skin and beautiful clothes is set off out instead, it is uncoordinated！Because clothes is greenery always, beautiful
Face and the tender skin of pale water are only fresh flower, have the colored pretty and dazzling life that can just show leaf only, and skin is only your expensive clothing
Clothes.Skin aging quickly, and 25 years old is exactly a turning point with advancing age, and skin starts to walk underscore after 25 years old,
Skin starts slowly long wrinkle after 30 years old, and the appearance of wrinkle directly exposes the age, therefore in order to which crease-resistant many producers set
Crease-resistant skin-protection product is counted.
Common wrinkle reduction class product is usually 2 kinds of approach on the market.One is pass through the battalion such as supplement skin collagen
Substance is supported, by achieving the effect that wrinkle reduction to skin moisturizing or nutrition skin, because collagen molecules amount is big, flesh
Skin absorption rate is poor, generally existing to take effect slowly, does not have the drawbacks such as effect substantially to the dynamics such as expression line line；One is utilize
High molecular material forms a film in skin surface and generates tension and even up or directly fill and lead up wrinkle, though effect can be seen immediately,
But in fact it is a kind of instant illusion, is controlled in table do not control completely, therefore how to realize the skin-protection product of a fundamentally anti-wrinkle
It is particularly important.
Summary of the invention
The one kind provided the purpose of the present invention is to solve above-mentioned the deficiencies in the prior art contains a variety of small-molecule peptides
The Essence and preparation method of removing wrinkle and resisting aging are compounded, the design formula is compounded using a variety of small-molecule peptides, and have molecular weight small,
The advantages that percutaneous absorption utilization rate is high, quick, while being broken for because of water shortage, the elastic force collagen protein delation at flesh bottom, free radical
The wrinkle and aging that the reasons such as bad are formed, it is comprehensive that human skin is repaired, to reach good, quick anti-wrinkle
Anti-ageing effect.
To achieve the goals above, the essence of a kind of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides designed by the present invention
Liquid, the Essence include the following raw material based on 100% weight percent: Sodium Hyaluronate 0.1-0.2%；Acrylic acid (ester)
Class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2-0.3%；Glycerol 5-7%；1,3 butanediol 4-6%；Dipeptides diamino
Butyryl benzyl amide diacetin 0.3-0.5%；- 5 0.2-0.3% of palmityl tetrapeptide；- 1 0.3-0.5% of palmityl tripeptides；
- 4 0.3-0.5% of Matrixyl；Carnosine 0.1-0.3%；Serine 0.1-0.3%；Arginine 0.1-0.3%；Niacinamide
0.1-0.3%；The deionized water of preservative 0.2-0.3% and remaining ratio.
Further, the Essence includes the following raw material based on 100% weight percent: Sodium Hyaluronate 0.15%；
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.25%；Glycerol 6%；1,3 butanediol 5%；Dipeptides diamino
Base butyryl benzyl amide diacetin 0.4%；Palmityl tetrapeptide -50.25%；Palmityl tripeptides -1 0.4%；Matrixyl-
4 0.4%；Carnosine 0.2%；Serine 0.2%；Arginine 0.2%；Niacinamide 0.2%；Preservative 0.25% and remaining ratio
Deionized water.
Further, the content of the carnosine is 98%.
Further, the preservative includes polyalcohol, fragrant fresh ketone, decoyl hydroximic acid, any one in glycerol caprylate.
Further, the preservative is polyalcohol.
The invention also discloses a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides, tools
Body the following steps are included:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid are then added in agitated kettle
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution,
It is then heated to 80-85 degree, then reduce mixing speed and is cooled down；
Step 2: after stirring pot temperature is down to 45-40 degree, dipeptides diaminobutyryl benzyl amide oxalic acid is sequentially added
Salt, palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, serine, arginine, niacinamide, and stir equal
It is even, while stirring cooling；
Step 3: being added preservative when spending when the temperature to 38-35, stirs 30 minutes, discharges after detection is qualified.
Further, the heating temperature in step 1 is 82 degree.
The Essence and preparation method for a kind of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides that the present invention obtains, because drawing
Into dipeptides diaminobutyryl benzyl amide diacetin, palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, flesh
The raw materials such as peptide, solve macromolecular collagen protein can not osmotic absorption drawback, can rapid osmotic, be easy by percutaneous absorption, reach
The effect of quick removing wrinkle and resisting aging；Finally this product is had the effect that
1, by using a variety of small-molecule peptides, additive and the nutrition for compounding serine, arginine, niacinamide etc are living
The collocation of skin agent can achieve the effect of mutual synergy；
2, using small-molecule peptide, it is easier to by percutaneous absorption, it is easier to embody effect；
3, peptides, amino acid itself are origin of amino acid, safe to the human body；
4, dipeptides diaminobutyryl benzyl amide diacetin belongs to synthesis nerve victory peptide, other products pair can be solved perfectly
The almost ineffective drawback of dynamic line such as expression line；It can improve skin water content from than more comprehensive mechanism and angle, resist
Free-radical oxidation, anti-saccharification, nutrition skin, the synthesis for promoting collagen, are finally reached anti crease and anti senile old purpose.
Specific embodiment
Below with reference to embodiment, the present invention is further described.
Embodiment 1:
A kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides provided in this embodiment, the Essence include
Following raw material based on 100% weight percent: Sodium Hyaluronate 0.1-0.2%；Acrylic acid (ester) class/C10-30 alkylol acrylamide
Acid esters cross-linked polymer 0.2-0.3%；Glycerol 5-7%；1,3 butanediol 4-6%；Dipeptides diaminobutyryl benzyl amide oxalic acid
Salt 0.3-0.5%；- 5 0.2-0.3% of palmityl tetrapeptide；- 1 0.3-0.5% of palmityl tripeptides；- 4 0.3- of Matrixyl
0.5%；Carnosine 0.1-0.3%；Serine 0.1-0.3%；Arginine 0.1-0.3%；Niacinamide 0.1-0.3%；Preservative
The deionized water of 0.2-0.3% and remaining ratio.
Essence described in implementing in this city includes the following raw material based on 100% weight percent: Sodium Hyaluronate
0.15%；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.25%；Glycerol 6%；1,3 butanediol 5%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.4%；Palmityl tetrapeptide -5 0.25%；Palmityl tripeptides -1 0.4%；Palm fibre
Palmitic acid acyl pentapeptide -4 0.4%；Carnosine 0.2%；Serine 0.2%；Arginine 0.2%；Niacinamide 0.2%；0.25% He of preservative
86.1% deionized water.
Further, the content of the carnosine is 98%.
Further, the preservative includes polyalcohol, fragrant fresh ketone, decoyl hydroximic acid, any one in glycerol caprylate.
Further, the preservative is polyalcohol.
The present embodiment also discloses a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides,
Specifically includes the following steps:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid are then added in agitated kettle
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution,
It is then heated to 80-85 degree, then reduce mixing speed and is cooled down；
Step 2: after stirring pot temperature is down to 45-40 degree (temperature is down to 45 degree in the present embodiment), two are sequentially added
Peptide diaminobutyryl benzyl amide diacetin, palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, silk ammonia
Acid, arginine, niacinamide, and stir evenly, while stirring cooling；
Step 3: preservative is added in (temperature is down to 38 degree in the present embodiment) when spending when the temperature to 38-35, stirs 30 points
Clock discharges after detection is qualified.
Further, the heating temperature in step 1 is 82 degree.
Since this formula is mainly mentioned using a variety of mild amino acid surfactant collocation matrines, tea tree saponin, Cortex Phellodendri
The medicinal herb components such as object are taken, main matter and its mechanism of action are as follows:
The various symptoms that this product skin occurs, so after-sun recovery must start with from this several respect.
The formula of the present embodiment is mainly compounded using a variety of small-molecule peptides and a variety of promotion skin cell vitality substances, more
Orientation reaches anti-wrinkle, anti-ageing effect, and main matter and its mechanism of action are as follows:
Dipeptides diaminobutyryl benzyl amide diacetin is a kind of synthesis nerve victory peptide for simulating calmette's serum, dipeptides two
Aminobutyryl benzyl amide diacetin acts on postsynaptic membrane, is that muscle nicotinic acetylcholine receptor (nmAChR) is reversible
Antagonist.Dipeptides diaminobutyryl benzyl amide diacetin inhibits the catechu of skin by the synthesis of inhibition SNARE acceptor
Phenol amine acetyl gallbladder (acetylcholine) excessively discharges, and local block nerves transmit contraction of muscle information, puts facial muscle
Pine achievees the purpose that the flat position (canthus, face and forehead) comforting microgroove, concentrating particularly suitable for mimetic muscle.Dipeptides two
Aminobutyryl benzyl amide diacetin mainly by inhibiting contraction of muscle to reduce the generation of wrinkle, with outstanding smooth and
Rapid anti-wrinkle performance is especially prominent to the effect of dynamic line.
Palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4 belong to class signal victory peptide, they can promote matrix
The synthesis of albumen (matrix protein) especially collagen, while being also possible to increase elastin laminin, hyaluronic acid, osamine
The generation of glycan and fibronectin.Such victory peptide promotes the synthesis of collagen by increasing stroma cell activity, so that
Skin seems more aobvious elasticity and youth, has good anti crease and anti senile old effect.
Carnosine (L-Carnosine), by being a kind of dipeptides being made of two kinds of amino acid of Beta-alanine and L-Histidine,
It is widely present in human body.After human body steps into the middle age, as the energy consumption of body slows down, excessive intake sugar, high concentration
Sugar can accelerate to react with protein glycation in vivo, generate AGEs (final product of saccharification).AGEs acts on skin, corium
It will lead to collagen and gradually lose elasticity, skin surface is made to form wrinkle, colour of skin yellowing etc..Carnosine can be oxidized or glycosyl
C=O reaction on the protein of change, prevents being cross-linked with each other for collagen, to lipid oxygen caused by free radical and metal ion
Change and saccharification has significant inhibition and scavenging effect, the process of delaying senility, is a kind of extremely effective anti-aging raw material.
This formula is because introduced dipeptides diaminobutyryl benzyl amide diacetin, palmityl tetrapeptide -5, palmityl three
The raw materials such as peptide -1, Matrixyl -4, carnosine, solve macromolecular collagen protein can not osmotic absorption drawback, can rapid osmotic,
It is easy by percutaneous absorption, reaches the effect of quick removing wrinkle and resisting aging；Finally this product is had the effect that
1, by using a variety of small-molecule peptides, additive and the nutrition for compounding serine, arginine, niacinamide etc are living
The collocation of skin agent can achieve the effect of mutual synergy；
2, using small-molecule peptide, it is easier to by percutaneous absorption, it is easier to embody effect；
3, peptides, amino acid itself are origin of amino acid, safe to the human body；
4, dipeptides diaminobutyryl benzyl amide diacetin belongs to synthesis nerve victory peptide, other products pair can be solved perfectly
The almost ineffective drawback of dynamic line such as expression line；It can improve skin water content from than more comprehensive mechanism and angle, resist
Free-radical oxidation, anti-saccharification, nutrition skin, the synthesis for promoting collagen, are finally reached anti crease and anti senile old purpose.
After tested, a kind of Essence for compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides that the present embodiment obtains, comparison are same
After prolonged use, using skin water content, free radical resisting oxygen is improved after this product, final anti-wrinkle effect is more for the Essence of sample
It is good, after two weeks, the basic wrinkle desalination of skin.
Embodiment 2:
A kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides provided in this embodiment, the Essence include
Following raw material based on 100% weight percent: Sodium Hyaluronate 0.1%；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters
Cross-linked polymer 0.2%；Glycerol 5%；1,3 butanediol 4%；Dipeptides diaminobutyryl benzyl amide diacetin 0.3%；Palm
Acyl tetrapeptide -5 0.2%；Palmityl tripeptides -1 0.3%；Matrixyl -4 0.3%；Carnosine 0.1%；Serine 0.1%；Essence
Propylhomoserin 0.1%；Niacinamide 0.1%；The deionized water of preservative 0.2% and 89%.
Further, the content of the carnosine is 98%.
Further, the preservative is fragrant fresh ketone.
The present embodiment also discloses a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides,
Specifically includes the following steps:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid are then added in agitated kettle
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution,
80 degree are then heated to, mixing speed is then reduced and is cooled down；
Step 2: stirring pot temperature be down to 40 degree after, sequentially add dipeptides diaminobutyryl benzyl amide diacetin,
Palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, serine, arginine, niacinamide, and stir evenly,
Cooling is stirred simultaneously；
Step 3: being added preservative when the temperature to 35 degree, stirs 30 minutes, discharges after detection is qualified.
After tested, a kind of Essence for compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides that the present embodiment obtains, comparison are same
After prolonged use, using skin water content, free radical resisting oxygen is improved after this product, final anti-wrinkle effect is more for the Essence of sample
It is good, after 10 days, the basic wrinkle desalination of skin.
Embodiment 3:
A kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides provided in this embodiment, the Essence include
Following raw material based on 100% weight percent: Sodium Hyaluronate 0.15%；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid
Ester cross-linked polymer 0.25%；Glycerol 6%；1,3 butanediol 5.5%；Dipeptides diaminobutyryl benzyl amide diacetin
0.38%；Palmityl tetrapeptide -5 0.26%；Palmityl tripeptides -10.4%；Matrixyl -4 0.4%；Carnosine 0.2%；Silk
Propylhomoserin 0.2%；Arginine 0.25%；Niacinamide 0.25%；The deionized water of preservative 0.25% and 85.51%.
Further, the content of the carnosine is 98%.
Further, the preservative is decoyl hydroximic acid.
The present embodiment also discloses a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides,
Specifically includes the following steps:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid are then added in agitated kettle
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution,
82 degree are then heated to, mixing speed is then reduced and is cooled down；
Step 2: after stirring pot temperature is down to 42 degree (temperature is down to 45 degree in the present embodiment), dipeptides is sequentially added
Diaminobutyryl benzyl amide diacetin, palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, silk ammonia
Acid, arginine, niacinamide, and stir evenly, while stirring cooling；
Step 3: being added preservative when the temperature to 36 degree, stirs 30 minutes, discharges after detection is qualified.
After tested, a kind of Essence for compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides that the present embodiment obtains, comparison are same
After prolonged use, using skin water content, free radical resisting oxygen is improved after this product, final anti-wrinkle effect is more for the Essence of sample
It is good, after 8 days, the basic wrinkle desalination of skin.
Embodiment 4:
A kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides provided in this embodiment, the Essence include
Following raw material based on 100% weight percent: Sodium Hyaluronate 0.18%；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid
Ester cross-linked polymer 0.28%；Glycerol 6.5%；1,3 butanediol 5.5%；Dipeptides diaminobutyryl benzyl amide diacetin
0.45%；Palmityl tetrapeptide -5 0.29%；Palmityl tripeptides -1 0.45%；Matrixyl -4 0.45%；Carnosine
0.25%；Serine 0.28%；Arginine 0.26%；Niacinamide 0.26%；The deionization of preservative 0.28% and 84.57%
Water.
Further, the content of the carnosine is 98%.
Further, the preservative is glycerol caprylate.
The present embodiment also discloses a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides,
Specifically includes the following steps:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid are then added in agitated kettle
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution,
84 degree are then heated to, mixing speed is then reduced and is cooled down；
Step 2: stirring pot temperature be down to 44 degree after, sequentially add dipeptides diaminobutyryl benzyl amide diacetin,
Palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, serine, arginine, niacinamide, and stir evenly,
Cooling is stirred simultaneously；
Step 3: being added preservative when the temperature to 36 degree, stirs 30 minutes, discharges after detection is qualified.
After tested, a kind of Essence for compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides that the present embodiment obtains, comparison are same
After prolonged use, using skin water content, free radical resisting oxygen is improved after this product, final anti-wrinkle effect is more for the Essence of sample
It is good, after a week, the basic wrinkle desalination of skin.
Embodiment 5:
A kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides provided in this embodiment, the Essence include
Following raw material based on 100% weight percent: Sodium Hyaluronate 0.2%；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters
Cross-linked polymer 0.3%；Glycerol 7%；1,3 butanediol 6%；Dipeptides diaminobutyryl benzyl amide diacetin 0.5%；Palm
Acyl tetrapeptide -5 0.3%；Palmityl tripeptides -1 0.5%；Matrixyl -4 0.5%；Carnosine 0.3%；Serine 0.3%；Essence
Propylhomoserin 0.3%；Niacinamide 0.3%；The deionized water of preservative 0.3% and 83.2%.
Further, the content of the carnosine is 98%.
Further, the preservative is polyalcohol.
The present embodiment also discloses a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides,
Specifically includes the following steps:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid are then added in agitated kettle
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution,
80 degree are then heated to, mixing speed is then reduced and is cooled down；
Step 2: stirring pot temperature be down to 40 degree after, sequentially add dipeptides diaminobutyryl benzyl amide diacetin,
Palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, serine, arginine, niacinamide, and stir evenly,
Cooling is stirred simultaneously；
Step 3: being added preservative when the temperature to 35 degree, stirs 30 minutes, discharges after detection is qualified.
After tested, a kind of Essence for compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides that the present embodiment obtains, comparison are same
After prolonged use, using skin water content, free radical resisting oxygen is improved after this product, final anti-wrinkle effect is more for the Essence of sample
It is good, after five days, the basic wrinkle desalination of skin.
Claims (8)
1. a kind of Essence of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides, it is characterised in that: the Essence includes pressing
The following raw material of 100% weight percent meter: Sodium Hyaluronate 0.1-0.2%；Acrylic acid (ester) class/C10-30 alkylol acrylamide acid
Ester cross-linked polymer 0.2-0.3%；Glycerol 5-7%；1,3 butanediol 4-6%；Dipeptides diaminobutyryl benzyl amide diacetin
0.3-0.5%；- 5 0.2-0.3% of palmityl tetrapeptide；- 1 0.3-0.5% of palmityl tripeptides；- 4 0.3- of Matrixyl
0.5%；Carnosine 0.1-0.3%；Serine 0.1-0.3%；Arginine 0.1-0.3%；Niacinamide 0.1-0.3%；Preservative
The deionized water of 0.2-0.3% and remaining ratio.
2. a kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides according to claim 1, it is characterised in that:
The Essence includes the following raw material based on 100% weight percent: Sodium Hyaluronate 0.15%；Acrylic acid (ester) class/
C10-30 alkylol acrylamide acid esters cross-linked polymer 0.25%；Glycerol 6%；1,3 butanediol 5%；Dipeptides diaminobutyryl benzyl acyl
Amine diacetin 0.4%；Palmityl tetrapeptide -50.25%；Palmityl tripeptides -1 0.4%；Matrixyl -4 0.4%；Carnosine
0.2%；Serine 0.2%；Arginine 0.2%；Niacinamide 0.2%；The deionized water of preservative 0.25% and remaining ratio.
3. a kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides according to claim 1 or 2, feature exist
In: the content of the carnosine is 98%.
4. a kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides according to claim 1 or 2, feature exist
In: the preservative include polyalcohol, fragrant fresh ketone, decoyl hydroximic acid, any one in glycerol caprylate.
5. a kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides according to claim 3, it is characterised in that:
The preservative includes polyalcohol, fragrant fresh ketone, decoyl hydroximic acid, any one in glycerol caprylate.
6. a kind of Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides according to claim 4, it is characterised in that:
The preservative is polyalcohol.
7. a kind of such as a kind of Essence of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides of any of claims 1-6
Preparation method, it is characterised in that: specifically includes the following steps:
Step 1: proportionally weighing raw material, and deionized water, Sodium Hyaluronate, acrylic acid (ester) are then added in agitated kettle
Class/C10-30 alkylol acrylamide acid esters cross-linked polymer, glycerol, 1,3 butanediols, stirring to transparent no particle uniform solution, then
It is heated to 80-85 degree, then reduce mixing speed and is cooled down；
Step 2: stirring pot temperature be down to 45-40 degree after, sequentially add dipeptides diaminobutyryl benzyl amide diacetin,
Palmityl tetrapeptide -5, palmityl tripeptides -1, Matrixyl -4, carnosine, serine, arginine, niacinamide, and stir evenly,
Cooling is stirred simultaneously；
Step 3: being added preservative when spending when the temperature to 38-35, stirs 30 minutes, discharges after detection is qualified.
8. a kind of preparation method of the Essence of compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides according to claim 7,
It is characterized by: the heating temperature in step 1 is 82 degree.
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| CN201711469999.4A CN109984952A (en) | 2017-12-29 | 2017-12-29 | A kind of Essence and preparation method of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides |
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| CN201711469999.4A CN109984952A (en) | 2017-12-29 | 2017-12-29 | A kind of Essence and preparation method of the compounding removing wrinkle and resisting aging containing a variety of small-molecule peptides |
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Application publication date: 20190709 |