CN112603857A - Antioxidant and anti-aging essence - Google Patents
Antioxidant and anti-aging essence Download PDFInfo
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- CN112603857A CN112603857A CN202011553572.4A CN202011553572A CN112603857A CN 112603857 A CN112603857 A CN 112603857A CN 202011553572 A CN202011553572 A CN 202011553572A CN 112603857 A CN112603857 A CN 112603857A
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- aging
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Classifications
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/34—Alcohols
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- Veterinary Medicine (AREA)
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- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of daily chemical products, and particularly discloses an antioxidant and anti-aging essence which comprises the following raw materials in parts by weight: 0.1-10 parts of tea polyphenol, 0.01-1 part of biological agent, 0.1-1 part of chelating agent, 1-10 parts of emollient, 1-10 parts of humectant, 0.1-5 parts of thickening emulsifier and 10-90 parts of purified water. The preparation method comprises the following steps: weighing purified water, adding the purified water into a stirring pot, adding a thickening agent under the stirring condition, and uniformly stirring; gradually heating to 70-75 deg.C under stirring, sequentially adding chelating agent, humectant, emollient, and thickening emulsifier, stirring for 10min with average value of 5min, vacuumizing to-0.4 kpa, and cooling; cooling to 40 deg.C, sequentially adding tea polyphenols and biological agent, and stirring for 10 min; and continuously cooling to 35 ℃, sampling and detecting, and obtaining the essence after the detection is qualified. The invention overcomes the defects of the prior art, has stronger moisturizing, oxidation resisting, wrinkle removing, anti-aging and repairing efficacies, and can obviously improve the smoothness, brightness, compactness and anti-irritation capability of the skin.
Description
Technical Field
The invention relates to the technical field of daily chemical products, and particularly belongs to antioxidant and anti-aging essence.
Background
Skin aging is a progressive physiological process and also a result of the combined action of various factors such as heredity, environment, psychology and the like. With the improvement of living standard of people, the functional requirements on skin care products are higher and higher, and skin care products with anti-aging effect are also in the endlessly.
At present, many skin care products with antioxidant and anti-aging effects are claimed in the market, but the effects of propaganda cannot be achieved in actual use, and in addition, the skin of a user is stimulated by adding a chemical preservative into the skin care products, so that the safety cannot be guaranteed.
Disclosure of Invention
The invention aims to provide the antioxidant and anti-aging essence, overcomes the defects of the prior art, has stronger moisturizing, antioxidant, wrinkle removing, anti-aging and repairing effects, and can obviously improve the smoothness, brightness, firmness and anti-irritation capacity of skin.
In order to solve the problems, the technical scheme adopted by the invention is as follows:
the antioxidant and anti-aging essence comprises the following raw materials in parts by weight: 0.1-10 parts of tea polyphenol, 0.01-1 part of biological agent, 0.1-1 part of chelating agent, 1-10 parts of emollient, 1-10 parts of humectant, 0.1-5 parts of thickening emulsifier and 10-90 parts of purified water.
Further, the essence comprises the following raw materials in parts by weight: 5 parts of tea polyphenol, 0.5 part of biological agent, 0.5 part of chelating agent, 5 parts of emollient, 5 parts of humectant, 2.5 parts of thickening emulsifier and 50 parts of purified water.
Further, the biological agent comprises one or more of diaminobutyrylbenzylamide diacetate, acyl palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tripeptide-38, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, acetyl tetrapeptide-5, acetyl hexapeptide-8, tripeptide-1 copper, pentapeptide-18, hexapeptide-11.
Further, the chelating agent comprises one or a combination of two or more of tetrasodium EDTA, disodium EDTA, and phytic acid.
Further, the emollient is selected from one of dioctyl carbonate, dioctyl ether, coco-caprylate/caprate, octyl dodecanol, and squalane.
Further, the humectant comprises one or more of glycerin, propylene glycol, 1, 3-propylene glycol, butylene glycol, hexylene glycol, sodium hyaluronate, glyceryl polyether-26 and an amino acid humectant.
Further, the thickening emulsifier comprises a combination of one or more of carbomer series, acrylic copolymer series, xanthan gum, Sepigel EG, SIMULGELNS, Aristoflex av, Aristoflex HMB.
The invention also provides a preparation method of the antioxidant and anti-aging essence, which comprises the following steps:
(1) weighing purified water, adding into a stirring pot, adding thickening emulsifier under stirring, and stirring at room temperature at a speed of 50-100r/min until stirring uniformly;
(2) gradually heating to 70-75 deg.C under stirring, sequentially adding chelating agent, humectant and emollient, stirring for 10min, averaging for 5min, vacuumizing to-0.4 kpa, and cooling;
(3) cooling to 40 deg.C, sequentially adding tea polyphenols and biological agent, and stirring for 10 min;
(4) and continuously cooling to 35 ℃, sampling and detecting, discharging after the detection is qualified, and obtaining the essence.
Compared with the prior art, the invention has the following implementation effects:
1. the tea polyphenol and the bioactive preparation are used in a matched manner, so that the effect of the tea polyphenol on resisting oxidation free radicals can be increased, the effects of the tea polyphenol on preventing ultraviolet rays from damaging skin, resisting aging, removing wrinkles, removing brown spots, resisting bacteria, preventing acnes, preventing edema and resisting allergy and the like can be exerted, the consumption of raw materials with high risk level in a formula is reduced, and the product is safer.
2. The essence provided by the invention has strong moisturizing, antioxidant, wrinkle removing, anti-aging and repairing effects, and can remarkably improve the smoothness, brightness, firmness and anti-irritation capability of skin.
3. The essence provided by the invention replaces the preservative by using tea polyphenol, is not added with an antiallergic agent, has no essence or pigment, is safe and reliable, has no toxicity to skin and mucosa, does not cause anaphylactic reaction, and avoids the inactivation of a bioactive preparation caused by the preservative.
Detailed Description
The present invention will be further described with reference to the following examples, but the present invention is not limited to these examples, and any modification is within the scope of the present invention without departing from the spirit of the present invention.
The tea polyphenol is a natural antioxidant, has remarkable antioxidation effect, can eliminate excessive free radicals generated in a human body, protects the structure of a cell membrane, slows down the aging of the human body, and prolongs the life of the human body. The tea polyphenols have unique protective and therapeutic effects on skin, and can effectively prevent skin injury caused by ultraviolet, and also has antiaging, wrinkle removing, speckle removing, acne preventing, edema preventing and antiallergic effects.
Dipeptide diaminobutyrylbenzylamide diacetate is a synthetic peptide simulating snake venom serum, and can prevent acetylcholine nerve conduction, achieve the effect of relaxing muscles, and further improve dynamic wrinkles. The risk factor is low, and is relatively safe, can be used with confidence, generally has no influence on pregnant women, and simultaneously has no pox-causing property.
Palmitoyl tripeptide-1 is a matrikine signal peptide that acts on the dermis layer to promote the synthesis of extracellular matrices such as collagen types I and III, elastin, structural glycoproteins such as laminin and fibronectin, strengthen the dermis layer, promote wound healing and tissue renewal and reconstruction, strengthen the integral skin layer, make the skin thicker and firmer, smooth wrinkles, and have a greater ability to resist uv radiation.
Palmitoyl tripeptide-5 is a cosmetic small molecular peptide which is most widely applied, and the purpose of wrinkle resistance of smoothing wrinkles and firming skin is achieved by stimulating the synthesis of skin collagen through tissue growth factor (TGF-beta). Studies have shown that such peptides promote collagen (type I, type II and type IV) synthesis and extracellular matrix protein production by increasing stromal cell activity, giving the skin a more youthful and elastic appearance.
Palmitoyl tripeptide-38 can promote the synthesis of six main molecules such as collagen I, III and IV, fibronectin, hyaluronic acid and laminin, and the like to fill wrinkles.
Acetyl hexapeptide-8 (hexapeptide) is a biomimetic peptide, an oligopeptide that mimics the N-terminus of SNAP-25 protein and consists of six amino acids. Its polypeptide structure is derived from a fragment of the human body's own SNAP-25 (synaptosome associated protein) N-terminus, and some chemical modifications are made. The reputation of "wrinkle-reducing new stars" is covered, and especially has better effect on lightening the depth of the eye wrinkles. The composition can inhibit the release of nerve conduction element acetylcholine and weaken the contraction of muscles, so that dynamic line expression lines are reduced, wrinkles are reduced, the activity of elastin is increased, the renewal capacity of epidermis is maintained, the skin is smooth and compact, the skin age is challenged to be reversed, and the youthful luster of the skin is displayed.
Tripeptide-1 copper, also known as copper trisepeptide, copper bluepetide. The copper peptide and the copper compound thereof can be used as an activator and an antioxidant for tissue remodeling, and the copper peptide is also a signal peptide, so that the degradation of a large number of collagen aggregates outside the scar, the synthesis of normal collagen of the skin, the generation of elastin, proteoglycan and glucosaminan, the growth speed and migration of different cell types, inflammation resistance and antioxidant reaction are promoted.
Example 1
The embodiment provides a preparation method of an antioxidant and anti-aging essence, which comprises the following steps:
(1) weighing 10 parts of purified water, adding the purified water into a stirring pot, adding a mixture of 0.5 part of carbomer 940 and Pemulen TR-2 under the stirring condition, and stirring at the speed of 50-100r/min at room temperature until the mixture is uniformly stirred;
(2) gradually heating to 70-75 ℃ under stirring, sequentially adding 0.1 part of tetrasodium EDTA, 5 parts of a mixture of propylene glycol and sodium hyaluronate and 5 parts of squalane, stirring for 10min, averaging for 5min, vacuumizing to-0.4 kpa, and cooling;
(3) cooling to 40 deg.C, sequentially adding 3 parts of tea polyphenols, 0.1 part of diaminobutyrylbenzyl amide diacetate and acyl palmitoyl tripeptide-1, and stirring for 10 min;
(4) and continuously cooling to 35 ℃, sampling and detecting, discharging after the detection is qualified, and obtaining the essence.
Example 2
The embodiment provides a preparation method of an antioxidant and anti-aging essence, which comprises the following steps:
(1) weighing 50 parts of purified water, adding the purified water into a stirring pot, adding a mixture of 2.5 parts of xanthan gum and Aristoflex HMB under the stirring condition, and stirring at the speed of 50-100r/min at room temperature until the mixture is uniformly stirred;
(2) gradually heating to 70-75 ℃ under stirring, sequentially adding 0.5 part of a mixture of EDTA disodium and phytic acid, 5 parts of a mixture of glycerin and an amino acid humectant and 5 parts of coconut oil alcohol-caprylate/caprate, stirring for 10min, averaging for 5min, vacuumizing to-0.4 kpa, and cooling;
(3) cooling to 40 deg.C, sequentially adding mixture of 5 parts of tea polyphenols, 0.5 parts of palmitoyl pentapeptide-4, acetyl tetrapeptide-5 and tripeptide-1 copper, and stirring for 10 min;
(4) and continuously cooling to 35 ℃, sampling and detecting, discharging after the detection is qualified, and obtaining the essence.
Example 3
The embodiment provides a preparation method of an antioxidant and anti-aging essence, which comprises the following steps:
(1) weighing 90 parts of purified water, adding the purified water into a stirring pot, adding 5 parts of a mixture of Aristoflex av and SIMULGELNS under the stirring condition, and starting stirring at the speed of 50-100r/min at room temperature until the mixture is uniformly stirred;
(2) gradually heating to 70-75 ℃ under stirring, sequentially adding 1 part of EDTA, 10 parts of a mixture of butanediol and glycerol polyether-26 and 10 parts of dioctyl carbonate, stirring for 10min, averaging for 5min, vacuumizing to-0.4 kpa, and cooling;
(3) cooling to 40 deg.C, sequentially adding 10 parts of tea polyphenols and 1 part of acyl palmitoyl tripeptide-1, and stirring for 10 min;
(4) and continuously cooling to 35 ℃, sampling and detecting, discharging after the detection is qualified, and obtaining the essence.
Comparative example 1
The raw material ratio and the preparation method of the comparative example are basically the same as those of the example 1, except that: no tea polyphenols and mixture of diaminobutyrylbenzylamide diacetate and acylpalmitoyl tripeptide-1 were added.
Comparative example 2
The raw material ratio and the preparation method of the comparative example are basically the same as those of the example 1, except that: no tea polyphenols were added.
Comparative example 3
The raw material ratio and the preparation method of the comparative example are basically the same as those of the example 1, except that: a mixture of diaminobutyrylbenzylamide diacetate and acylpalmitoyl tripeptide-1 was not added.
Anti-aging test
Testing an instrument: cotomermameter MPA580 host, manufactured by Courage + Khazaka, Germany (CK, Germany), the probe used was a Revistometer RV600 elastofiber tissue test probe.
Subject: a normal healthy female subject of 45-70 years of age.
Grouping: the subjects are divided into 7 groups according to each age, each group comprises 10 persons, and each group comprises 45-50 persons, 51-55 persons, 56-60 persons, 61-65 persons and 66-70 persons in each age.
Examples 1 to 3 groups used the anti-aging essence prepared in examples 1 to 3, comparative examples 1 to 3 used the anti-aging essence prepared in comparative examples 1 to 3, comparative example 4 used the anti-aging essence prepared in example 1, and the essence was placed at 40 ℃ for 8 hours before use, and comparative example 5 used the anti-aging essence prepared in comparative example 2 and the essence was placed at 40 ℃ for 8 hours before use.
The tester area: the forehead area 2cm above the middle of the eyebrow, the chin area 2cm below the middle of the lower lip, and the left and right cheek areas at the intersection of the nose tip and the pupil.
The testing steps are as follows: the blank value (R) was measured 30min after cleaning the test area2，R5，R7Wherein R is2＝Ua/Uf，R5＝Ur/Ue，R7＝Ur/Uf)。
Uf-maximum skin stretch;
Ue-the amount of stretching of the skin at 0.1 seconds after a constant negative pressure has been applied to the skin, the amount of stretching of the elastic portion being localized;
Urafter the negative pressure is removed, the skin rapidly returns to its original state, again with a value of the elastic part UrNamely, the recovery value and the viscoelastic part value, or the plastic part value, of the skin after the negative pressure is removed for 0.1 second;
Ua-the recovery value of the skin from the removal of the negative pressure to the next successive test of the skin surface plus the negative pressure;
then, the sample was applied evenly to the face, followed by a trial in the morning and evening each day without using any other cosmetic, and continuously applied for 4 weeks to test the R of the skin in the test areas at 1 week, 2 weeks, 3 weeks, and 4 weeks, respectively2，R5，R7. The test of the same subject is performed by the same measuring person. By testing R of the skin before and after use2，R5，R7The value changes to evaluate the skin anti-aging efficacy of the product.
The specific experimental results are shown in table 1:
TABLE 1 results of anti-aging experiments
The results in table 1 show that the antioxidant and anti-aging essence provided by the invention has strong moisturizing, antioxidant, wrinkle removing, anti-aging and repairing effects, and can remarkably improve the smoothness, brightness, firmness and anti-irritation capability of skin.
The comparison of the results of the group of example 1 and the groups of comparative examples 1 to 3 shows that the tea polyphenol and the bioactive preparation have better synergistic effect; the comparison of the results of the group of example 1 and the group of comparative example 4 shows that the essence has better stability; compared with the results of the comparative example 2 and the comparative example 5, the essence without tea polyphenol has poor stability and is not easy to store.
The foregoing is merely exemplary and illustrative of the present inventive concept and various modifications, additions and substitutions of similar embodiments may be made to the specific embodiments described by those skilled in the art without departing from the inventive concept or exceeding the scope of the claims as defined in the accompanying claims.
Claims (8)
1. An antioxidant and anti-aging essence is characterized in that: the essence comprises the following raw materials in parts by weight: 0.1-10 parts of tea polyphenol, 0.01-1 part of biological agent, 0.1-1 part of chelating agent, 1-10 parts of emollient, 1-10 parts of humectant, 0.1-5 parts of thickening emulsifier and 10-90 parts of purified water.
2. The antioxidant and anti-aging essence according to claim 1, characterized in that: the essence comprises the following raw materials in parts by weight: 5 parts of tea polyphenol, 0.5 part of biological agent, 0.5 part of chelating agent, 5 parts of emollient, 5 parts of humectant, 2.5 parts of thickening emulsifier and 50 parts of purified water.
3. The antioxidant and anti-aging essence according to claim 1, characterized in that: the biological agent comprises one or more of diaminobutyrylbenzylamide diacetate, acyl palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tripeptide-38, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, acetyl tetrapeptide-5, acetyl hexapeptide-8, tripeptide-1 copper, pentapeptide-18 and hexapeptide-11.
4. The antioxidant and anti-aging essence according to claim 1, characterized in that: the chelating agent comprises one or the combination of two or more of EDTA tetrasodium, EDTA disodium, EDTA and phytic acid.
5. The antioxidant and anti-aging essence according to claim 1, characterized in that: the emollient is selected from one of dioctyl carbonate, dioctyl ether, coco-caprylate/caprate, octyl dodecanol and squalane.
6. The antioxidant and anti-aging essence according to claim 1, characterized in that: the humectant comprises one or more of glycerin, propylene glycol, 1, 3-propylene glycol, butanediol, hexanediol, sodium hyaluronate, glyceryl polyether-26 and an amino acid humectant.
7. The antioxidant and anti-aging essence according to claim 1, characterized in that: the thickening emulsifier comprises one or more of carbomer series, acrylic copolymer series, xanthan gum, Sepigel EG, SIMULGELNS, Aristoflex av, Aristoflex HMB.
8. A method for preparing the antioxidant and antiaging essence as claimed in any one of claims 1 to 7, characterized by comprising: the method comprises the following steps:
(1) weighing purified water, adding into a stirring pot, adding thickening emulsifier under stirring, and stirring at room temperature at a speed of 50-100r/min until stirring uniformly;
(2) gradually heating to 70-75 deg.C under stirring, sequentially adding chelating agent, humectant and emollient, stirring for 10min, averaging for 5min, vacuumizing to-0.4 kpa, and cooling;
(3) cooling to 40 deg.C, sequentially adding tea polyphenols and biological agent, and stirring for 10 min;
(4) and continuously cooling to 35 ℃, sampling and detecting, discharging after the detection is qualified, and obtaining the essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011553572.4A CN112603857A (en) | 2020-12-24 | 2020-12-24 | Antioxidant and anti-aging essence |
Applications Claiming Priority (1)
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Cited By (1)
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| CN117297997A (en) * | 2023-11-28 | 2023-12-29 | 杭州湃肽生化科技有限公司 | High-efficiency skin tightening polypeptide composition and product application thereof |
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Application publication date: 20210406 |