CN111904906B - Composition for repairing skin barrier and improving skin resistance and preparation method thereof - Google Patents
Composition for repairing skin barrier and improving skin resistance and preparation method thereof Download PDFInfo
- Publication number
- CN111904906B CN111904906B CN202010776147.5A CN202010776147A CN111904906B CN 111904906 B CN111904906 B CN 111904906B CN 202010776147 A CN202010776147 A CN 202010776147A CN 111904906 B CN111904906 B CN 111904906B
- Authority
- CN
- China
- Prior art keywords
- skin
- parts
- extract
- composition
- repairing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a composition for repairing skin barriers and improving skin resistance and a preparation method thereof, wherein the composition comprises the following raw material components: 2-3 parts of peony root extract, 1-2 parts of alpine edelweiss extract, 3-5 parts of schizosaccharomyces cerevisiae fermentation product extract, 5.5-9.6 parts of bionic polypeptide, 12-16 parts of solvent, 3-4 parts of beta-glucan, 1-2 parts of ergothioneine, 0.1-0.5 part of hyaluronic acid, 0.15-0.6 part of hydrolyzed sodium hyaluronate and 0.3-0.4 part of preservative. The invention has the beneficial effects that: the composition for repairing the skin barrier and improving the skin resistance is prepared by compounding the peony root extract, the alpine edelweiss extract, the secondary fission yeast fermentation product extract and the bionic polypeptide, has the effects of enhancing the self-repairing capability of the skin and improving the skin immunity, and can be used for increasing skin receptor signals and improving the aged skin in a multi-channel manner by adding the bionic polypeptide.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition for repairing a skin barrier and improving skin resistance and a preparation method thereof.
Background
With the influence of factors such as global climate change, living environment, living habits, natural aging and the like, various problems appear on the skin of people, the skin care product with single effect cannot meet the nursing requirement of the problem skin, and with the improvement of living standard, people pay more and more attention to maintenance, the quality requirement of the skin care product is higher and higher, the skin care products with various effects are also endless, but the quality and the effects of the skin care products are different.
In daily care, in order to solve various skin problems, a plurality of skin care products with different effects are needed, so that the daily skin care is quite complicated, the time consumption is high, the modern and quick rhythm of life is not suitable, and in addition, in order to rapidly solve various skin problems at one time, the skin care products are used blindly, the skin is easy to have the eutrophication phenomenon, the skin burden is increased, and only the skin becomes more sensitive and the resistance is reduced.
Disclosure of Invention
The composition for repairing the skin barrier and improving the skin resistance is safe and effective in component, and can achieve the effects of diminishing inflammation, deeply nourishing and moisturizing, enhancing the skin elasticity and effectively improving the symptoms of damaged skin.
The technical scheme of the invention is as follows:
a composition for repairing skin barrier and improving skin resistance comprises the following raw material components:
2-3 parts of peony root extract, 1-2 parts of alpine edelweiss extract, 3-5 parts of schizosaccharomyces cerevisiae fermentation product extract, 5.5-9.6 parts of bionic polypeptide, 12-16 parts of solvent, 3-4 parts of beta-glucan, 1-2 parts of ergothioneine, 0.1-0.5 part of hyaluronic acid, 0.15-0.6 part of hydrolyzed sodium hyaluronate and 0.3-0.4 part of preservative.
Preferably, the composition for repairing skin barrier and improving skin resistance comprises the following raw material components: 3 parts of a peony root extract, 1 part of a leontopodium alpinum extract, 4 parts of a schizosaccharomyces cerevisiae fermentation product extract, 7 parts of biomimetic polypeptide, 13 parts of a solvent, 3 parts of beta-glucan, 1 part of ergothioneine, 0.3 part of hyaluronic acid, 0.3 part of hydrolyzed sodium hyaluronate and 0.35 part of a preservative.
The main active ingredients of the peony root extract are paeoniflorin, phenols, flavones, tannins, volatile oil, amino acids and the like, and the peony root extract shows excellent skin care effect on free radical scavenging, nitrogen oxide generation, elastase inhibition and the like. In addition, the radix Paeoniae extract also has skin activating and antiaging effects, and has good moisture keeping effect.
The extract of the alpine edelweiss has the effects of inhibiting the activity of elastase and promoting the generation of the endothelin, can slow down the degradation of the elastin, can maintain the elasticity of the skin, has the function of resisting wrinkles on the skin, has a certain inhibiting effect on certain bacteria, and has the functions of resisting bacteria and diminishing inflammation.
The yeast bifidus fermentation product extract is an anti-aging active component produced after the fermentation of bifidobacterium and the cracking of thalli. The yeast schizosaccharomyces cerevisiae extract is rich in micromolecules which are beneficial to skin care, such as vitamin B group, mineral substances, amino acids and the like, is a high-quality yeast purification only used for skin care, can strengthen the self-repairing capability of skin, can strengthen the metabolism of cuticle, and reduces the damage of ultraviolet rays to the skin, thereby achieving the effect of improving the skin quality, and the skin can be experienced to be fine and tender after being continuously used for a period of time. In addition, the yeast bifidus fermentation product extract can reduce the sensitivity of the skin and is suitable for the sensitive skin and the skin with damaged barrier.
The bionic polypeptide refers to a polypeptide which is obtained by screening a polypeptide sequence with a specific function from human protein and then performing in vitro synthesis to obtain the polypeptide with the same sequence and important physiological functions. The peptides have biological characteristics, can fundamentally improve and repair various problems of skin when being added into cosmetics, and particularly have obvious effects on the aspects of supplementing skin nutrition, resisting wrinkles, resisting aging and the like.
The beta-glucan has various effects of resisting aging, removing wrinkles, repairing scars, resisting allergy, diminishing inflammation and the like in cosmetics.
Ergothioneine is a natural antioxidant, is highly protective to cells, and can stimulate the natural antioxidant defense system of cells, and block pigmentation; can reduce protein glycation to prevent age-related loss of skin elasticity, modify and improve facial contours; ergothioneine has absorption wavelength similar to that of DNA, can reduce the formation of active oxygen to the maximum, protect cells from radiation damage and avoid ultraviolet ray damage to skin, and is a sun-screening component with excellent effect. In addition, ergothioneine has anti-inflammatory effect in skin cells, and can relieve skin inflammation and photodamage caused by ultraviolet.
Hyaluronic acid can penetrate into epidermis layer of skin, promote supply of skin nutrition and excretion of waste, thereby preventing skin aging, and caring skin, and can promote proliferation and division of epidermal cells, scavenge oxygen free radicals, and promote skin regeneration of wound part.
The hydrolyzed sodium hyaluronate is an acidic mucopolysaccharide which naturally exists in corneal skin and can absorb 1000 times of moisture of the corneal skin so as to achieve the purposes of retaining skin moisture, preventing the moisture from losing through epidermis, improving skin nutrition metabolism by repairing barriers when the skin is damaged, enabling the skin to be smooth and elastic, and being a good transdermal absorption promoter while keeping moisture.
The preservative mainly inhibits the growth and reproduction of microorganisms in the cosmetics, keeps the stable property of the cosmetics, ensures that the cosmetics are not easy to deteriorate after being uncovered for use, and prolongs the storage time.
The composition for repairing the skin barrier and improving the skin resistance is prepared by compounding a peony root extract, a leontopodium alpinum extract, a yeast fermentation product extract and bionic polypeptide, so that the composition is fresh and cool in skin feel and is not sticky when in use, the self-repairing capability of the skin is enhanced, the addition of the bionic polypeptide can increase skin receptor signals in a multi-channel manner and improve the aged skin, and the composition for repairing the skin barrier and improving the skin resistance is safe and effective in components, and can achieve the effects of diminishing inflammation, fading red and calming, deeply nourishing and moisturizing and effectively improving the symptoms of damaged skin.
In the radix paeoniae alba extract, the content of paeoniflorin is more than 50 wt%, preferably, the content of paeoniflorin in the radix paeoniae alba extract is 53 wt% -90 wt%; more preferably, the paeoniflorin content in the radix paeoniae alba extract is 68 wt%.
The bionic polypeptide consists of palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, acetyl hexapeptide-8 and carnosine.
The raw material components of the bionic polypeptide comprise 11-2 parts of palmitoyl tripeptide, 71-2 parts of palmitoyl tetrapeptide, 83-5 parts of acetyl hexapeptide and 0.5-0.6 part of carnosine.
Palmitoyl tripeptide-1 is effective as a cosmetic raw material for preventing and smoothing wrinkles and firming skin, and it can make skin more youthful, smoother and more elastic. Research shows that the wrinkle-removing effect and activity of the palmitoyl tripeptide-1 are far better than those of the conventional vitamin A, and no side effect exists.
Palmitoyl tetrapeptide-7 can help promote the production of collagen, and relieve fine wrinkles.
Acetyl hexapeptide-8 is a neurotransmitter inhibitory peptide, has high anti-wrinkle activity and small side effect, and the acetyl hexapeptide-8 participates in competing SNAP-25 at the site of a vacuolar complex, thereby influencing the formation of the complex. When the vesicular complex is slightly unstable, the vesicles cannot effectively release neurotransmitters, thereby causing a decrease in muscle contraction and preventing the formation of wrinkles.
Carnosine is a crystalline solid composed of two amino acids, beta-alanine and L-histidine. Carnosine has strong antioxidant ability, and can scavenge Reactive Oxygen Species (ROS) and alpha-beta unsaturated aldehydes, which are formed by over-oxidation of fatty acids in cell membranes during oxidative stress.
The solvent is polyalcohol, preferably butanediol or glycerol.
The preservative is a mixture of p-hydroxyacetophenone and caprylyl hydroximic acid, and preferably, the preservative is a mixture of p-hydroxyacetophenone and caprylyl hydroximic acid in a weight ratio of 1-2: 1, in a mixture of the components.
A method for preparing the composition for repairing skin barrier and improving skin resistance comprises the following steps:
(1) mixing and heating a solvent and hyaluronic acid to 80-85 ℃ until the solvent and hyaluronic acid are completely dissolved to obtain a solution 1;
(2) cooling the solution 1 to 40-50 deg.C, adding ergothioneine, radix Paeoniae extract, herba Leontopodii Adoratae extract, yeast fermentation product extract, bionic polypeptide, beta-dextran, hydrolyzed sodium hyaluronate, and antiseptic, mixing, and stirring.
On the basis of the composition for repairing skin barriers and improving skin resistance, a cosmetic auxiliary material matrix is added, and a skin care product in a conventional form can be prepared according to a conventional cosmetic process. The cosmetic adjunct base includes, but is not limited to, 1, humectants, such as propylene glycol and the like; 2. thickeners such as stearic acid, lauryl alcohol, xanthan gum, carbomer, carboxymethylcellulose, hydroxyethylcellulose, and the like; 3. emulsifiers such as cetearyl glucoside, PEG-100 stearate, tweens, and the like; 4. emollients such as caprylic/capric triglyceride, dioctyl carbonate, squalane, tocopherol acetate, cyclopentadimethylsiloxane, octylmethicone, isododecane, dimethicone, and the like; 5. an essence; 6. a pigment. When the composition for repairing skin barriers and improving skin resistance is used for preparing skin care products, the specific addition amount of each cosmetic auxiliary material matrix can be the conventional amount in the technical field of cosmetics, and the skin care products in the conventional form have relative fluidity and can be in any one of aqua, cream, emulsion, lotion and facial mask in appearance. The addition amount of the composition for repairing the skin barrier and improving the skin resistance in the skin care product is 3-8 wt%.
The beneficial effects of the invention are as follows:
1. the composition for repairing the skin barrier and improving the skin resistance is prepared by compounding the peony root extract, the alpine edelweiss extract, the secondary fission yeast fermentation product extract and the bionic polypeptide, has the effects of enhancing the self-repairing capability of the skin and improving the skin immunity, and can be used for increasing skin receptor signals and improving the aged skin in a multi-channel manner by adding the bionic polypeptide.
2. The composition for repairing skin barriers and improving skin resistance is safe and effective in components, can achieve the effects of diminishing inflammation, reducing redness and calming, deeply nourishing and moisturizing, enhancing skin elasticity and effectively improving the symptoms of damaged skin, and has no toxic or side effect after long-term use.
3. The composition for repairing the skin barrier and improving the skin resistance is simple in preparation method, and wide in applicable population due to no irritation and no sensitization.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
In the following examples, the paeonia lactiflora extract was obtained from sierra hu-nan, a biotechnology limited, wherein the content of paeoniflorin in the paeonia lactiflora extract was 68 wt%; the extract of Hibiscus sabdariffa is purchased from Xian' jin Chemicals Co., Ltd; the secondary split yeast fermentation product extract is purchased from Xian kang Nuo chemical Co., Ltd;
the preservative used by the invention is p-hydroxyacetophenone and caprylyl hydroximic acid according to the weight ratio of 1: 1.
The compositions for repairing skin barriers and improving skin resistance in examples 1-3 and the compositions for repairing skin barriers and improving skin resistance in comparative examples 1-3 of the invention comprise the following raw materials as shown in Table 1:
in Table 1, "-" means "none
TABLE 1 composition formula for repairing skin barrier and improving skin resistance
The preparation method comprises the following steps:
(1) mixing butanediol and hyaluronic acid, heating to 80 ℃ until the butanediol and hyaluronic acid are completely dissolved to obtain a solution 1;
(2) cooling solution 1 to 45 deg.C, adding ergothioneine, radix Paeoniae extract, Leontopodium alpinum extract, yeast fermentation product extract, bionic polypeptide (palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, acetyl hexapeptide-8, carnosine, as shown in comparative example 3), beta-dextran, hydrolyzed sodium hyaluronate, and antiseptic, mixing and stirring well to obtain the final product.
The skin moisturizer prepared from the composition for repairing skin barrier and improving skin resistance has the formula and the preparation method shown in the table 2:
TABLE 2 emollient Water formulations
The preparation method comprises the following steps: adding the phase A materials into a stirring pot, heating to 80 deg.C, stirring to dissolve uniformly, cooling to 40 deg.C, sequentially adding phase B and phase C materials, and stirring uniformly.
Safety evaluation of composition for repairing skin barrier and improving skin resistance
The subjects were 30 persons in total, and the specific gender and age were determined randomly (according to the inclusion and exclusion criteria of "diagnosis and treatment of contact dermatitis cosmetic"), and the test substance was the composition for repairing skin barrier and improving skin resistance as described in example 3 of the present invention.
The test method comprises the following steps: 0.2g of the test object is put into a spot tester, and then the spot tester with the test object is pasted on the back or the forearm curve side of the subject by using a non-irritating adhesive tape and is lightly pressed by hands to be evenly pasted on the skin for 24 hours. Removing the test substance after 24h, observing skin reaction at 0.5h, 12h, 24h and 48h after patch removal, recording the result according to skin reaction grading standard in cosmetic hygiene Specification (2007 edition), the identification standard is shown in Table 3, and the test result is shown in Table 4
TABLE 3 identification standards
TABLE 4 Patch test results
As can be seen from Table 4, the skin barrier-repairing and skin resistance-improving composition of the present invention does not cause any allergy or discomfort to the human body, thereby indicating that the skin barrier-repairing and skin resistance-improving composition of the present invention is safe and non-irritating to the skin.
Study of skin barrier repair efficacy of lotions prepared from the formulations of table 2
The subjects were selected: selecting 150 subjects, randomly dividing the subjects into 5 groups of 30 persons, 1-4 test groups and control groups, wherein the age range of the subjects is 25-50 years, the face of the subject suffers from mild acne, and the evaluation work of cosmetics can be completed by matching with workers;
the test method comprises the following steps: the skin care products of test group using emollient water No. 2, the control group 1 is blank control group using emollient water corresponding to No. 1, and the control groups 2-4 respectively use emollient water corresponding to No. 3, No. 4, and No. 5The skin preparation is applied twice a day in the morning and at night, and during the experiment period, the subjects do not use any skin preparation, and the average value of the loss of the percutaneous water in the cheek part after the test of 0 week and the test of continuous use to 4 weeks and 7 weeks is measured by using a German CK company TM300 tester, and the loss of the percutaneous water is abbreviated as TEWL (g/m) 2h) I.e. how many grams of water per square meter of area is lost per hour. TEWL is a condition that indicates water loss by measuring the water vapor pressure gradient at the skin surface, reflecting the water permeation barrier of the skin. When barrier function is impaired, the TEWL value increases; conversely, TEWL decreases, suggesting barrier repair; the results are shown in table 5: the more intact the skin protection layer, the higher the moisture content and the lower the TEWL value for skin moisture loss, i.e. the skin barrier is repaired.
TABLE 5 TEWL repair results
| Week 0 g/m2h | G/m at week 42h | G/m at week 72h | |
| Test group | 25.12 | 23.98 | 22.73 |
| Control group 1 | 24.32 | 24.01 | 23.88 |
| Control group 2 | 24.87 | 24.62 | 24.27 |
| Control group 3 | 25.01 | 24.68 | 24.29 |
| Control group 4 | 24.93 | 24.68 | 24.15 |
As can be seen from Table 5, the skin moisturizer prepared from the composition for repairing the skin barrier and improving the skin resistance has good skin barrier repairing effect, and the repairing performance of the skin moisturizer is obviously better than that of the skin moisturizers in the control groups 2 to 4.
The emollient water prepared in comparative example 1, which did not contain the peony root extract, decreased TEWL value by 0.6 after seven weeks of use in the subject of # 3 emollient water; the skin lotion prepared in comparative example 2, which did not contain the extract of leontopodium alpinum and the extract of the fermentation product of saccharomyces diaviscidum, decreased TEWL value by 0.72 after seven weeks of use in the subject of # 4 skin lotion; the emollient water prepared in comparative example 3 contained no biomimetic polypeptide, and thus the TEWL value decreased by 0.78 after seven weeks of use for the subject with # 5 emollient water; the value of TEWL was decreased by 0.44 in the subjects of the blank control group, it was found that the decrease in TEWL values was not significant in the subjects of the control groups 2-4, and the skin barrier was not well restored in the subjects of the control groups 2-4.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. The composition for repairing skin barriers and improving skin resistance is characterized by comprising the following raw material components:
2-3 parts of paeonia lactiflora root extract, 1-2 parts of alpine edelweiss extract, 3-5 parts of schizosaccharomyces cerevisiae fermentation product extract, 5.5-9.6 parts of bionic polypeptide, 12-16 parts of solvent, 3-4 parts of beta-glucan, 1-2 parts of ergothioneine, 0.1-0.5 part of hyaluronic acid, 0.15-0.6 part of hydrolyzed sodium hyaluronate and 0.3-0.4 part of preservative; the bionic polypeptide consists of palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, acetyl hexapeptide-8 and carnosine.
2. The composition for repairing skin barrier and improving skin resistance according to claim 1, wherein the raw material components comprise: 3 parts of a peony root extract, 1 part of a leontopodium alpinum extract, 4 parts of a schizosaccharomyces cerevisiae fermentation product extract, 7 parts of biomimetic polypeptide, 13 parts of a solvent, 3 parts of beta-glucan, 1 part of ergothioneine, 0.3 part of hyaluronic acid, 0.3 part of hydrolyzed sodium hyaluronate and 0.35 part of a preservative.
3. The composition for repairing skin barrier and improving skin resistance as claimed in claim 1, wherein the content of paeoniflorin in the radix Paeoniae extract is greater than 50 wt%.
4. The composition for repairing skin barriers and improving skin resistance according to claim 1, wherein the biomimetic polypeptide is composed of the following raw material components: 11-2 parts of palmitoyl tripeptide, 71-2 parts of palmitoyl tetrapeptide, 83-5 parts of acetyl hexapeptide and 0.5-0.6 part of carnosine.
5. The composition for repairing skin barrier and improving skin resistance according to claim 1, wherein the solvent is a polyol, and the polyol is butylene glycol or glycerin.
6. The composition for repairing skin barrier and improving skin resistance according to claim 1, wherein the preservative is a mixture of p-hydroxyacetophenone and caprylyl hydroximic acid, and the weight ratio of the p-hydroxyacetophenone to the caprylyl hydroximic acid is 1-2: 1.
7. A method for preparing the composition for repairing skin barrier and improving skin resistance of claim 1, comprising the steps of:
(1) mixing and heating a solvent and hyaluronic acid to 80-85 ℃ until the solvent and hyaluronic acid are completely dissolved to obtain a solution 1;
(2) Cooling the solution 1 to 40-50 deg.C, adding ergothioneine, radix Paeoniae extract, herba Leontopodii Adoratae extract, yeast fermentation product extract, bionic polypeptide, beta-dextran, hydrolyzed sodium hyaluronate, and antiseptic, mixing, and stirring.
8. A skin care product comprising the composition for repairing skin barrier and improving skin resistance of claim 1 and a cosmetic adjuvant base.
9. The skin care product according to claim 8, wherein the skin care product is any one of a water aqua, a cream, an emulsion, a lotion and a mask, and the composition for repairing skin barrier and improving skin resistance is added into the skin care product in an amount of 3-8 wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010776147.5A CN111904906B (en) | 2020-08-05 | 2020-08-05 | Composition for repairing skin barrier and improving skin resistance and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010776147.5A CN111904906B (en) | 2020-08-05 | 2020-08-05 | Composition for repairing skin barrier and improving skin resistance and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111904906A CN111904906A (en) | 2020-11-10 |
| CN111904906B true CN111904906B (en) | 2022-05-24 |
Family
ID=73287126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010776147.5A Active CN111904906B (en) | 2020-08-05 | 2020-08-05 | Composition for repairing skin barrier and improving skin resistance and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111904906B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113081888A (en) * | 2021-03-25 | 2021-07-09 | 榆林市恒丽贸易有限公司 | Polypeptide repairing extracting solution and preparation method thereof |
| CN112915060A (en) * | 2021-04-19 | 2021-06-08 | 广州广妆生物科技有限公司 | Emulsion containing anti-aging composition and preparation method thereof |
| CN113069392A (en) * | 2021-04-25 | 2021-07-06 | 宜兴市强月彤商贸有限公司 | Anti-blue-light skin care composition and application thereof |
| CN113230152A (en) * | 2021-05-14 | 2021-08-10 | 杭州万融茶界科技有限公司 | Composition with whitening and anti-aging functions and preparation method thereof |
| CN114073658B (en) * | 2021-11-23 | 2023-09-15 | 湖北省麦诗特生物科技有限公司 | Essence composition containing liposome capable of resisting photoaging injury and preparation method thereof |
| CN114010563A (en) * | 2021-11-30 | 2022-02-08 | 上海宜侬生物科技有限公司 | Component with brightening and anti-aging effects and application thereof |
| CN115364006B (en) * | 2021-12-29 | 2024-02-09 | 皓雨(广州)化妆品制造有限公司 | Anti-aging barrier repairing composition and anti-aging barrier repairing skin care product |
| CN115137665B (en) * | 2022-07-19 | 2023-07-25 | 陕西慧康生物科技有限责任公司 | Composition with long-acting moisturizing and soothing effects and application thereof |
| CN116159083A (en) * | 2023-03-06 | 2023-05-26 | 安琪纽特股份有限公司 | Composition for skin and application thereof |
| CN116440248B (en) * | 2023-03-31 | 2024-03-12 | 广州市尊爱日用化妆品有限公司 | External preparation composition containing peptide and hydroxypropyl tetrahydropyran triol and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101651A (en) * | 2019-05-31 | 2019-08-09 | 广东盛美化妆品有限公司 | Yeast tunning lysis object is split containing two releive repair Essence and preparation method thereof |
| CN111419734A (en) * | 2020-05-14 | 2020-07-17 | 华熙生物科技股份有限公司 | Composition for improving astaxanthin transdermal absorption and application thereof |
-
2020
- 2020-08-05 CN CN202010776147.5A patent/CN111904906B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101651A (en) * | 2019-05-31 | 2019-08-09 | 广东盛美化妆品有限公司 | Yeast tunning lysis object is split containing two releive repair Essence and preparation method thereof |
| CN111419734A (en) * | 2020-05-14 | 2020-07-17 | 华熙生物科技股份有限公司 | Composition for improving astaxanthin transdermal absorption and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111904906A (en) | 2020-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111904906B (en) | Composition for repairing skin barrier and improving skin resistance and preparation method thereof | |
| CN111700853B (en) | Cosmetic composition with anti-allergy repairing effect and application thereof | |
| CN109953926B (en) | Skin care product with five-vitamin anti-wrinkle and anti-aging effects and preparation method thereof | |
| CN113648235B (en) | Composition for immediately removing wrinkles, eye mask essence, wrinkle-removing cosmetic and application | |
| JP2011519353A (en) | Active ingredients that stimulate fibroblast proliferation and / or activity | |
| KR20120041090A (en) | Fibroblast proliferator | |
| CN110946784A (en) | Skin care composition with functions of improving skin barrier function and enhancing skin health | |
| CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
| CN113244144B (en) | Face cream for brightening skin color | |
| CN109172390A (en) | A kind of multiple-effect of the extract containing Ganoderma Sinense is preserved youthful looks lotion and preparation method thereof | |
| CN113576975A (en) | Easily-absorbed anti-aging composition and preparation method and application thereof | |
| CN113786379A (en) | Lactic acid bacteria whitening and repairing essence and preparation method thereof | |
| CN112891286A (en) | Beautifying and firming repair cream and preparation method thereof | |
| CN111991286A (en) | Eye cream composition for fading fine wrinkles and preparation method thereof | |
| CN110302091B (en) | Composition containing nicotinamide adenine dinucleotide for resisting skin aging and preparation method and application thereof | |
| CN115517999A (en) | Anti-aging composition and application thereof in beauty and skin care | |
| CN111529450A (en) | Deep moisturizing repair composition, skin care product and preparation method thereof | |
| CN114748367A (en) | Moisturizing repair essence and preparation method thereof | |
| CN114588061A (en) | Anti-aging and wrinkle-removing composition, preparation method thereof and skin care product | |
| CN112120949B (en) | Water-light moisturizing essence and preparation method thereof | |
| CN113730321A (en) | Anti-wrinkle firming composition and application thereof in cosmetics | |
| CN112773761A (en) | Cosmetic composition, essence and preparation method thereof | |
| CN112656731A (en) | Composition with red-repairing effect and preparation method and application thereof | |
| CN114712285B (en) | Composition with anti-wrinkle effect and preparation method and application thereof | |
| CN113081874A (en) | Personalized beauty treatment method based on skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |