CN112807255A - Anti-wrinkle composition and application thereof in cosmetics - Google Patents
Anti-wrinkle composition and application thereof in cosmetics Download PDFInfo
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- CN112807255A CN112807255A CN202010207270.5A CN202010207270A CN112807255A CN 112807255 A CN112807255 A CN 112807255A CN 202010207270 A CN202010207270 A CN 202010207270A CN 112807255 A CN112807255 A CN 112807255A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention relates to an anti-wrinkle composition and application thereof in cosmetics, wherein the anti-wrinkle composition consists of a peony root extract, carnosine and snake venom tripeptide. The anti-wrinkle composition combines the peony root extract, the carnosine and the snake venom tripeptide, and the three act synergistically, thereby producing the effect of 1+1+1 > 3 on anti-wrinkle.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an anti-wrinkle composition and application thereof in cosmetics.
Background
Aging of human skin refers to the phenomenon of skin appearance, internal structure and function deterioration caused by exogenous or endogenous factors. The factors causing skin aging are many and can be roughly divided into two factors, namely internal factors and external factors: 1) extrinsic factors: damage of ultraviolet rays, action of gravity, wrong maintenance, improper diet, bad living habits and bad living environment; 2) intrinsic factors: age increase, autonomic nerve dysfunction, visceral dysfunction, endocrine disorders.
Oxidation is an important factor in these causes of aging, and is a cost for oxygen acquired by human respiration, and free radicals which cause aging are generated simultaneously with oxidation. Free radicals are an important factor causing skin damage and aging. The damage to the skin caused by excessive accumulation of free radicals is mainly shown as follows: the skin loses softness, the elasticity is reduced, and a series of aging manifestations such as wrinkles, dry cornification, no luster, reduction/oxidation of glutathione, excessive lipofuscin deposition and the like appear.
The reduced Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine and glycine, the active component of the GSH is reduced glutathione which can participate in the oxidation-reduction process in vivo and can be freely and basically combined with the body so as to resist the damage of an oxidant to sulfydryl, protect protein containing sulfydryl and enzyme containing sulfydryl in a cell membrane from being damaged and delay skin aging. The radix Paeoniae extract can significantly improve the ratio of reduced/oxidized glutathione in human normal keratinocyte, thereby achieving the effect of anti-wrinkle.
Disclosure of Invention
Based on this, there is a need for an anti-wrinkle composition containing an extract of paeonia lactiflora pall, which can exert an anti-wrinkle effect.
In addition, the application of the anti-wrinkle composition in cosmetics is also needed to be provided.
An anti-wrinkle composition, the anti-wrinkle composition comprising an extract of radix Paeoniae, carnosine and a snake venom-like tripeptide.
The anti-wrinkle composition is applied to cosmetics.
An anti-wrinkle cosmetic comprises radix Paeoniae extract, carnosine, tripeptide similar to snake venom, additive and water.
The radix Paeoniae extract can significantly improve the ratio of reduced/oxidized glutathione in human normal keratinocyte, thereby achieving the effect of anti-wrinkle. Carnosine is a multifunctional physiological dipeptide, has antioxidant effect, and can capture hydroxyl free radicals, scavenge peroxidate free radicals, and revive the activity of aged human fibroblasts. The carnosine can react with small-molecule carbonyl-containing compounds (such as aldehyde, ketone and the like) to prevent mutual crosslinking of biological macromolecules, can competitively glycosylate with aldose or ketose to protect proteins and other peptides, and can also react with C ═ O on oxidized or glycosylated proteins to play a role in delaying senescence. The snake venom-like tripeptide (dipeptide diaminobutyrylbenzylamide diacetate) acts as an effective smoothing and wrinkle-removing active by relaxing facial muscles in a manner consistent with neuromuscular blocking compounds of venom of the viper, acts on the postsynaptic membrane, is a reversible antagonist of muscle nicotinic acetylcholine receptors, restores the elasticity of facial skin and reduces false wrinkles, makes the skin plump and glossy, full of elasticity and assumes a healthy natural state. The anti-wrinkle cosmetic combines the peony root extract, the carnosine and the snake venom tripeptide, and the three act together to realize synergistic effect, thereby having the effect of 1+1+1 > 3 on resisting wrinkles.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description taken in conjunction with the accompanying drawings. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The application discloses an anti-wrinkle composition, which consists of a peony root extract, carnosine and snake venom tripeptide.
The radix Paeoniae extract can significantly improve the ratio of reduced/oxidized glutathione in human normal keratinocyte, thereby achieving the effect of anti-wrinkle.
Carnosine is a multifunctional physiological dipeptide, has antioxidant effect, and can capture hydroxyl free radicals, scavenge peroxidate free radicals, and revive the activity of aged human fibroblasts. The carnosine can react with small-molecule carbonyl-containing compounds (such as aldehyde, ketone and the like) to prevent mutual crosslinking of biological macromolecules, can competitively glycosylate with aldose or ketose to protect proteins and other peptides, and can also react with C ═ O on oxidized or glycosylated proteins to play a role in delaying senescence.
The snake venom-like tripeptide (dipeptide diaminobutyrylbenzylamide diacetate) acts as an effective smoothing and wrinkle-removing active by relaxing facial muscles in a manner consistent with neuromuscular blocking compounds of venom of the viper, acts on the postsynaptic membrane, is a reversible antagonist of muscle nicotinic acetylcholine receptors, restores the elasticity of facial skin and reduces false wrinkles, makes the skin plump and glossy, full of elasticity and assumes a healthy natural state.
The anti-wrinkle cosmetic combines the peony root extract, the carnosine and the snake venom tripeptide, and the three act together to realize synergistic effect, thereby having the effect of 1+1+1 > 3 on resisting wrinkles.
Specifically, the anti-wrinkle composition comprises the following components in parts by weight: 0.2 to 2 parts of peony root extract, 0.05 to 1 part of carnosine and 2 to 10 parts of snake venom tripeptide.
In a specific embodiment, in the anti-wrinkle composition, the part by mass of the paeonia lactiflora root extract is 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts or 1.8 parts; the mass parts of the carnosine are 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part or 0.9 part; the mass parts of the snake venom tripeptide are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts.
Preferably, when the anti-wrinkle composition is used, the mass percentage concentration of the peony root extract is 0.2-2%, the mass percentage concentration of carnosine is 0.05-1%, and the mass percentage concentration of snake venom tripeptide is 2-10%.
Such an anti-wrinkle composition can be applied to various fields, and in particular, it can be applied to cosmetics.
According to the regulations of the regulations on the supervision and control of cosmetics and hygiene, cosmetics refer to "daily chemical industry products for cleaning, removing bad smell, caring skin, beautifying and decorating by spreading any part (skin, hair, nails, lips, etc.) on the surface of human body by smearing, spraying or other similar methods".
Therefore, skin care products also belong to cosmetics.
Specifically, the cosmetic may be a facial mask liquid, skin lotion, essence, lotion, cream or makeup.
The application also discloses an anti-wrinkle cosmetic, which consists of the peony root extract, carnosine, snake venom tripeptide, an additive and water.
The radix Paeoniae extract can significantly improve the ratio of reduced/oxidized glutathione in human normal keratinocyte, thereby achieving the effect of anti-wrinkle.
Carnosine is a multifunctional physiological dipeptide, has antioxidant effect, and can capture hydroxyl free radicals, scavenge peroxidate free radicals, and revive the activity of aged human fibroblasts. The carnosine can react with small-molecule carbonyl-containing compounds (such as aldehyde, ketone and the like) to prevent mutual crosslinking of biological macromolecules, can competitively glycosylate with aldose or ketose to protect proteins and other peptides, and can also react with C ═ O on oxidized or glycosylated proteins to play a role in delaying senescence.
The snake venom-like tripeptide (dipeptide diaminobutyrylbenzylamide diacetate) acts as an effective smoothing and wrinkle-removing active by relaxing facial muscles in a manner consistent with neuromuscular blocking compounds of venom of the viper, acts on the postsynaptic membrane, is a reversible antagonist of muscle nicotinic acetylcholine receptors, restores the elasticity of facial skin and reduces false wrinkles, makes the skin plump and glossy, full of elasticity and assumes a healthy natural state.
The anti-wrinkle cosmetic combines the peony root extract, the carnosine and the snake venom tripeptide, and the three act together to realize synergistic effect, thereby having the effect of 1+1+1 > 3 on resisting wrinkles.
Every hundred parts of the anti-wrinkle cosmetic comprises the following components in parts by mass: 0.2 to 2 parts of peony root extract, 0.05 to 1 part of carnosine, 2 to 10 parts of snake venom tripeptide, additive and the balance of water.
In a specific embodiment, the anti-wrinkle cosmetic comprises 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts or 1.8 parts of the peony root extract by weight; the mass parts of the carnosine are 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part or 0.9 part; the mass parts of the snake venom tripeptide are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts.
The peony root extract is usually an alcohol extraction product.
In this embodiment, the paeonia radix extract is a paeonia radix extract. In other embodiments, other peony root extracts may be selected, for example, white peony root extract.
The additives are generally selected according to the actual product and determined in parts by mass.
Generally, additives are a variety of raw materials required for the manufacture of cosmetics. Specifically, the additive may be at least one selected from the group consisting of a moisturizer, an oil, an antioxidant, a preservative, a sunscreen, a pigment, an adhesive and a perfume.
Taking the anti-wrinkle cosmetic as an example of a cream (eye cream), the mass part of the additive may be 28.28 parts, in which case 29.58 parts of the additive may be 0.2 part of carbomer, 3 parts of butanediol, 5 parts of propylene glycol, 1.5 parts of betaine, 0.2 part of allantoin, 0.1 part of disodium EDTA, 1 part of macadamia nut oil, 3 parts of isononyl isononanoate, 1.5 parts of sorbitan olivate and cetearyl alcohol, 1.7 parts of cetearyl alcohol, 1.8 parts of polydimethylsiloxane, 3.5 parts of caprylic/capric triglyceride, 5 parts of squalane, 0.3 parts of polyacrylate-13 and polyisobutylene and polysorbate-20, 0.4 parts of 1, 2-hexanediol and caprylyl hydroxamic acid, 0.08 part of essence. When the anti-wrinkle cosmetic is cream (eye cream), the preparation method comprises the following steps:
weighing various raw materials according to the mass parts, stirring and dispersing carbomer, adding butanediol, propylene glycol, betaine, allantoin and EDTA disodium, heating to 80 ℃, keeping the temperature and stirring until the materials are dissolved uniformly to obtain a first mixed solution;
mixing macadamia nut seed oil, isononyl isononanoate, sorbitan olivine oleate, cetearyl alcohol, polydimethylsiloxane, caprylic/capric acid reduction/oxidation glutathione and squalane, heating to 75 ℃, preserving heat and stirring until the mixture is dissolved uniformly to obtain a second mixed solution;
mixing the first mixed solution and the second mixed solution (preferably adding the second mixed solution into the first mixed solution) under stirring to obtain a third mixed solution;
homogenizing the third mixed solution for 5min, adding polyacrylate-13, polyisobutylene and polysorbate-20, and further homogenizing for 5min to obtain a fourth mixed solution; and
cooling the fourth mixture to about 45 deg.C, sequentially adding radix Paeoniae extract, carnosine, snake venom tripeptide, 1, 2-hexanediol, caprylyl hydroximic acid and essence, stirring, and cooling to room temperature to obtain cream.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Example 1: preparation of anti-wrinkle eye cream
According to the total mass part of 100 parts, the part of the radix paeoniae rubra extract is 0.5 part, the part of carnosine is 0.05 part, the part of the snake venom tripeptide is 2 parts, the additives are 0.2 part of carbomer, 3 parts of butanediol, 5 parts of propylene glycol, 1.5 parts of betaine, 0.2 part of allantoin, 0.1 part of disodium EDTA, 1 part of macadamia nut oil, 3 parts of isononyl isononanoate, 1.5 parts of sorbitan olivate oleate and cetostearyl alcohol, 1.7 parts of cetostearyl alcohol, 1.8 parts of polydimethylsiloxane, 3.5 parts of caprylic/capric triglyceride, 5 parts of squalane, 0.3 parts of polyacrylate-13 and polyisobutylene and polysorbate-20, 0.4 parts of 1, 2-hexanediol and caprylyl hydroximic acid and 0.08 part of essence, and the balance of water.
Weighing various raw materials according to the mass parts, stirring and dispersing carbomer, adding butanediol, propylene glycol, betaine, allantoin and EDTA disodium, heating to 80 ℃, keeping the temperature, and stirring until the materials are dissolved uniformly to obtain a first mixed solution;
mixing macadamia nut seed oil, isononyl isononanoate, sorbitan olivine oleate, cetearyl alcohol, polydimethylsiloxane, caprylic/capric triglyceride and squalane, heating to 75 ℃, preserving heat and stirring until the mixture is dissolved uniformly to obtain a second mixed solution;
mixing the first mixed solution and the second mixed solution (preferably adding the second mixed solution into the first mixed solution) under stirring to obtain a third mixed solution;
homogenizing the third mixed solution for 5min, adding polyacrylate-13, polyisobutylene and polysorbate-20, and further homogenizing for 5min to obtain a fourth mixed solution; and
cooling the fourth mixture to about 45 deg.C, sequentially adding radix Paeoniae extract, carnosine, snake venom tripeptide, 1, 2-hexanediol, octanoyl hydroximic acid and essence, stirring, and cooling to room temperature to obtain anti-wrinkle eye cream.
Example 2: preparation of anti-wrinkle eye cream
Example 2 is different from example 1 only in that the part of the extract of radix paeoniae rubra is 1.2 parts, the part of carnosine is 0.5 part, the part of tripeptide resembling snake venom is 6 parts, and the rest is not different.
An anti-wrinkle eye cream was prepared in the same manner as in example 1.
Example 3: preparation of anti-wrinkle eye cream
Example 3 is different from example 1 only in that 2 parts of radix paeoniae rubra extract, 1 part of carnosine, 10 parts of snake venom tripeptide, and the rest are not different.
An anti-wrinkle eye cream was prepared in the same manner as in example 1.
Example 4: skin repair efficacy assay based on human keratinocytes (based on reduced/oxidized glutathione)
Raw materials and drugs
Human keratinocytes (obtained from a 54-year-old donor), DPBS (bosch de), dmso (Sigma), trypsin (Sigma), 70% alcohol, NaOH, paeonia radix extract (liquid, shanghai nux xi mei ltd), carnosine (shanghai nux xi mei ltd), snake venom tripeptides (shanghai nux xi mei ltd).
Device
CO2Incubator (Thermo), clean bench (Sujing Antai), inverted microscope (Olympus), micro-oscillator (its Linbel), Glutathione detection kit (Glutathione (GSSG/GSH), detection kit, Ref No. # ADI-900-.
1) Preparation of a test sample: based on the cytotoxicity assay, efficacy assay concentrations were determined and corresponding samples were prepared according to table 1 below, using DMEM medium as the solvent.
Table 1: design of sample experiment
Sulforaphane is a known substance that can increase the expression of reduced/oxidized glutathione, which can be used for a positive control.
2) Cell culture: human keratinocytes were obtained from a 54 year old donor, and for the experiments, keratinocytes had been cultured in monolayers until 100% confluence was reached. After digesting human keratinocytes, the cells were dispersed in DMEM medium, counted in a Hemacytometer, and then diluted with DMEM to a concentration of 5X 104cells/mL. The diluted cell solutions were inoculated into 6-well plates, each containing 2mL of 1X 105cells/well. At 37 ℃ 5% CO2Was cultured in an incubator for 24 hours. After 24 hours of cell culture, the cells were observed for complete adherent growth, and if the cells were completely adherent, the original medium was removed and washed with DPBS.
3) Sample addition: after DPBS was removed, the samples prepared above were added separately, and after sample addition, the mixture was placed at 37 ℃ in 5% CO2Was cultured in an incubator for 48 hours.
4) Collecting and detecting supernatant: collecting the culture medium, centrifuging at 13500rpm for 10min, collecting the precipitate to obtain cells, crushing the cells, centrifuging at 13500rpm for 10min, collecting the supernatant, and measuring the reduced glutathione content and the oxidized glutathione content in the culture medium corresponding to different samples by using a specific glutathione detection kit, thereby obtaining the ratio of the reduced glutathione to the oxidized glutathione, which is specifically shown in Table 2 below.
Table 2: the ratio of reduced/oxidized glutathione in the culture medium corresponding to different samples
*: compared with a control group 3, the difference has statistical significance (p is less than or equal to 0.01);
**: compared with a control group 3, the difference has statistical significance (p is less than or equal to 0.01);
***: compared with the control group 3, the difference has statistical significance (p is less than or equal to 0.05).
As can be seen from Table 2, the control groups 1 to 3 and the sample groups 1 to 3 can both play a role in improving the expression of reduced/oxidized glutathione, the sample groups 1 to 3 have obviously stronger improvement on the expression of reduced/oxidized glutathione than the control groups 1 and 2, and have no disadvantage compared with the control group 3. It can be seen that by combining the use of the extract of the peony root with carnosine, the synergistic effect of the two increases the synthesis of reduced/oxidized glutathione, resulting in an effect of 1+1 > 2.
In addition, in the sample groups 1-3, the sample group 2 has the strongest improvement capability on the expression of reduced/oxidized glutathione.
Example 5: evaluation of anti-wrinkle efficacy
Test samples: test samples were prepared according to table 3 below, using purified water as the solvent.
Table 3: anti-wrinkle efficacy evaluation test sample
The testing steps are as follows:
the subjects were divided into 7 groups of 10 persons each, and each of the 7 groups was used once a day in the morning, at noon and at night by applying 0.5mL to the face and gently looping until complete absorption.
The skin friction force and the skin elasticity of each user were measured by a skin measuring instrument (Derma-Expert MC760) at regular follow-up survey, and the skin was measured once every 10 days in one stage, and the test sites were cheeks on both sides.
The mean values of the skin parameters at the start of the experiment (D0), the mean values of the skin parameters at the 10 th day of the experiment (D10), and the mean values of the skin parameters at the 20 th day of the experiment (D20) were recorded for each group of volunteers, respectively, and the difference between the mean values of the skin parameters at the 10 th day of the experiment and at the start of the experiment (D10-D0) and the difference between the mean values of the skin parameters at the 20 th day of the experiment and at the 10 th day of the experiment (D20-D10) were calculated, resulting in tables 4 and 5 below.
Table 4: skin friction test results
| Blank group | Control group 1 | Control group 2 | Control group 3 | Sample set 1 | Sample set 2 | Sample set 3 | |
| D10-D0 | -3.22 | -28.01 | -20.22 | -22.54 | -42.13 | 66.24 | 54.23 |
| D20-D10 | +1.28 | -26.28 | -18.52 | -23.36 | -46.43 | 61.23 | 56.28 |
In combination with Table 4, the smaller the values of D10-D0, D20-D10, the smoother the skin and the shallower the wrinkles. Therefore, the control groups 1-3 and the sample groups 1-3 can play a role in improving the skin, and the improvement of the sample groups 1-3 on the skin is obviously stronger than that of the control groups 1-3. Thus, by combining the radix paeoniae extract, carnosine and the snake venom-like tripeptide, the three synergistically act to improve the skin, resulting in an effect of 1+1+1 > 3.
In addition, the improvement of the skin was the greatest in sample group 2 among sample groups 1 to 3.
Table 5: skin elasticity test results
| Blank group | Control group 1 | Control group 2 | Control group 3 | Sample set 1 | Sample set 2 | Sample set 3 | |
| D10-D0 | 0.25 | 8.25 | 4.23 | 6.51 | 10.08 | 16.24 | 12.65 |
| D20-D10 | -0.32 | 7.93 | 5.02 | 6.89 | 11.01 | 14.23 | 12.24 |
In combination with Table 5, the larger the values of D10-D0, D20-D10, the better the skin elasticity. Therefore, the control groups 1-3 and the sample groups 1-3 can play a role in improving the skin, and the improvement of the sample groups 1-3 on the skin is obviously stronger than that of the control groups 1-3. Thus, by combining the radix paeoniae extract, carnosine and the snake venom-like tripeptide, the three synergistically act to improve the skin, resulting in an effect of 1+1+1 > 3.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. An anti-wrinkle composition, comprising an extract of radix Paeoniae, carnosine and a snake venom-like tripeptide.
2. The anti-wrinkle composition according to claim 1, wherein the anti-wrinkle composition consists of the following components in parts by mass: 0.2 to 2 parts of peony root extract, 0.05 to 1 part of carnosine and 2 to 10 parts of snake venom tripeptide.
3. The anti-wrinkle composition according to claim 2, wherein the paeonia lactiflora root extract is present in an amount of 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, or 1.8 parts by mass;
the mass parts of the carnosine are 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part or 0.9 part;
the mass parts of the snake venom tripeptide are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts.
4. The anti-wrinkle composition according to any one of claims 1 to 3, wherein the concentration of the radix paeoniae alba extract is 0.2-2 wt%, the concentration of carnosine is 0.05-1 wt%, and the concentration of the snake venom tripeptide is 2-10 wt%.
5. Use of the anti-wrinkle composition according to any one of claims 1 to 4 in cosmetics.
6. The use according to claim 5, wherein the cosmetic product is a facial mask solution, a skin lotion, a serum, an emulsion, a cream or a make-up.
7. An anti-wrinkle cosmetic is characterized by comprising a peony root extract, carnosine, a snake venom-like tripeptide, an additive and water.
8. The anti-wrinkle cosmetic according to claim 7, wherein the anti-wrinkle cosmetic consists of the following components per hundred parts by mass: 0.2 to 2 parts of peony root extract, 0.05 to 1 part of carnosine, 2 to 10 parts of snake venom tripeptide, additive and the balance of water.
9. The anti-wrinkle cosmetic according to claim 8, wherein the part by mass of the peony root extract is 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts or 1.8 parts;
the mass parts of the carnosine are 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part or 0.9 part;
the mass parts of the snake venom tripeptide are 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts.
10. The anti-wrinkle cosmetic according to claim 8, wherein the additive is selected from at least one of a moisturizer, a grease, an antioxidant, a preservative, a sunscreen, a pigment, an adhesive, and a fragrance.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693964A (en) * | 2021-08-16 | 2021-11-26 | 深圳市维琪医药研发有限公司 | Novel use of peptide derivatives for preparing compositions for skin rejuvenation |
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