CN106038350A - Composite growth factor skincare gel and preparation method thereof - Google Patents
Composite growth factor skincare gel and preparation method thereof Download PDFInfo
- Publication number
- CN106038350A CN106038350A CN201610380847.6A CN201610380847A CN106038350A CN 106038350 A CN106038350 A CN 106038350A CN 201610380847 A CN201610380847 A CN 201610380847A CN 106038350 A CN106038350 A CN 106038350A
- Authority
- CN
- China
- Prior art keywords
- skin
- growth factor
- composite growth
- stock solution
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses composite growth factor skincare gel. The composite growth factor skincare gel is prepared from, by mass, 1-50% of composite growth factor stock solution, 0.5-1.5% of carbomer 940NF, 1-10% of 4% sodium hydroxide solution, 0.1-2% of sodium hyaluronate, 0.1-10% of trehalose, 1-10% of mannitol, 0.85-0.95% of sodium chloride, 0.1-5% of dextranum 40, 0.00003-0.3% of heparin sodium and the balance injection water. Rh-bFGF and KGF in the composite growth factor stock solution are compounded according to a specific proportion and used for a skincare gel formula; on the basis of moisture preservation, skin redness and swelling can be effectively relieved, and skin wounds and scars can be effectively restored; skin is prevented from bearing toxic irritation of other skincare products, and the composite growth factor skincare gel mainly aims at people suffering from severe skin aging, skin redness and swelling and skin local wounds or breakage, such as hormone face patients for long-term skincare.
Description
Technical field
The present invention relates to skin care field, particularly to a kind of skin-care gel and preparation method thereof.
Background technology
Abundant along with socioeconomic continuous progress and material life, skin care item, are no longer that the most only rich just use
The thing that must rise, nowadays skin care item have come into ordinary citizen house.Skin care item are of a great variety, and feature is different, each skin protection
The manufacture composition of product and effect, different according to different skin properties.Simultaneously because now the most various poor qualities color make-up and
Skin care item emerge in an endless stream, the most this product of inferior quality of some middle-aged and elderly people, result in more skin problem even skin
Skin disease, such as skin aging acceleration, xerosis cutis pruritus, pigementation, clogging of pores, red swelling of the skin, hormone face etc., therefore
Now the kind of skin care item should not be confined to again common skin daily moisturizing nursing, and should ensure nursing on the basis of energy
Preferably tackle special skin properties.
The people of long-term existence skin problem or dermatosis broadly falls into the crowd with specific skin character, particularly suffers from
The people of the dermatosis such as hormone face, because there is wound in local skin, so special skin care item should be used to carry out daily nursing.And
The multiple somatomedin found the most successively, passes through the research to its physiological function, mechanism of action and gene regulation etc. gradually
Deeply finding, they play very important effect in skin repair.Somatomedin is used for field of medicaments at present, its product
Drug effect notable, and less in cosmetic field application.The most on the market still without preferably repairing for specific skin character and
The skin care item of nursing.
Summary of the invention
Present invention aims to above-mentioned the deficiencies in the prior art, it is provided that a kind of composite growth factor skin-care gel and
Its preparation method.
The technical solution used in the present invention is: a kind of composite growth factor skin-care gel, it includes by mass percentage
The following raw material components of meter:
Wherein the effective ingredient in composite growth factor stock solution is rh-bFGF:KGF=1:0.6～1.
Specifically, the rh-bFGF in the present invention refers to recombination basic fibroblast somatomedin, and it has skin protection, repairs and make
With, cell growth microenvironment can be improved, promote fibroblastic growth promoter, constantly replace aged cells with new cell,
Thus calm red swelling of the skin, repair skin trauma and cicatrix.KGF in the present invention refers to keratinocyte growth factor, and it passes through
Promote cell propagation, migrate, break up, survive, DNA repairs and induction has the expression of enzyme of function of detoxification to active oxygen
Strengthen epithelium function, thus protective epithelium avoids the damage of toxicant, red swelling of the skin and skin trauma are had auxiliary and repairs
Effect.Being combined by specific proportioning by KGF with rh-bFGF in the present invention, as the daily nursing of the skin of special nature, it is main
, red swelling of the skin, local skin wound more serious for skin aging or the crowd of breakage, such as hormone face patient etc. protect for a long time
Skin uses.
As the further improvement of such scheme, described composite growth factor stock solution includes following group by mass percentage
Point:
Composite growth factor effective ingredient 0.0001～0.6%
Phosphate buffer surplus.
As the further improvement of such scheme, the concentration of described phosphate buffer is 20～200mmol/L.Specifically
Ground, phosphate buffered saline water is water for injection.
As the further improvement of such scheme, described heparin sodium effectively becomes with composite growth factor in composite growth stock solution
The mass ratio divided is 1:1～3.
The composite growth factor stock solution of the present invention can be dispersed in gel, simultaneously by heparin sodium and composite growth because of
The special proportioning of sub-effective ingredient, the skin care effect making gel is more notable, more longlasting, more stable.
As the further improvement of such scheme, gel granularity is 0.1～100 μm.The present invention restriction to gel granularity
Make it have good absorbability, especially for aging more serious, skin that absorbability is weak.
As the further improvement of such scheme, the pH value of gel is 6.5～7.5.
The preparation method of a kind of above-mentioned composite growth factor skin-care gel, it comprises the steps:
A) prepare skin-care gel substrate: weigh Carbomer 940NF by raw materials quality percentages, add water for injection and make it
The most swelling, add 4% sodium hydroxide solution adjust pH value to 7.0, by hyaluronate sodium, trehalose with water for injection dissolve after
Joining mix homogeneously in swelling good Carbomer 940NF, obtain skin-care gel substrate, autoclave sterilization is stand-by after processing；
B) composite growth factor stock solution is prepared: use the mode of biofermentation purification to respectively obtain rh-bFGF and KGF, press
Proportioning raw materials and mass percent add phosphate buffer mixing, prepare composite growth factor stock solution, the most stand-by；
C) finished product is prepared: after being dissolved by heparin sodium water for injection by raw materials quality percentages, join answering of step b)
Close in somatomedin stock solution, then filtration after mixture is mixed with mannitol, sodium chloride, Dextran 40 lysate, by gained
Filtrate joins in the skin-care gel substrate of step a) and stirs, and subpackage obtains finished product.
As the further improvement of such scheme, in preparation process, temperature controls in the range of 20～30 DEG C.
As the further improvement of such scheme, described in step a), in autoclave sterilization processing procedure, temperature controls
In the range of 120～123 DEG C, Stress control is in the range of 0.1～0.12Mpa, and the time controls in the range of 15～30min.
The invention has the beneficial effects as follows:
(1) present invention compounds in skin-care gel formula by rh-bFGF Yu KGF in specific proportions, can be at moisturizing base
Effective calm red swelling of the skin, reparation skin trauma and cicatrix on plinth, avoid skin is stimulated by the toxicity of other skin care item simultaneously,
, red swelling of the skin, local skin wound more serious mainly for skin aging or the crowd of breakage, such as hormone face patient etc. are long-term
Skin protection uses.
(2) present invention selects gel phase carriers, it is ensured that the long-effect active of composite growth factor, is prone to skin simultaneously and inhales
Receive, be particularly well-suited to aging more serious, the daily nursing of skin that absorbability is weak.
(3) preparation method of the present invention is excellent, technique is simple, production efficiency is high, beneficially industrialized production.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is specifically described, in order to the personnel of art are to the present invention's
Understand.It is necessary that at this present invention will be further described it is emphasized that embodiment is only intended to, it is impossible to be interpreted as this
The restriction of invention protection domain, art person skilled in the art, the non-intrinsically safe present invention made according to foregoing invention content
The improvement of property and adjustment, should still fall within protection scope of the present invention.The most following mentioned raw material is unspecified, is
Commercially available prod.
Embodiment 1
A kind of composite growth factor skin-care gel, it includes following raw material components by mass percentage:
Wherein the effective ingredient in composite growth factor stock solution is rh-bFGF:KGF=1:0.6.Composite growth factor stock solution
Include the composite growth factor effective ingredient of 0.0001% and the phosphoric acid that concentration is 20mmol/L of surplus by mass percentage
Salt buffer.Heparin sodium is 1:1～3 with the mass ratio of composite growth factor effective ingredient in composite growth stock solution simultaneously.
Preparation method:
A) prepare skin-care gel substrate: weigh Carbomer 940NF by raw materials quality percentages, add water for injection and make it
The most swelling, add 4% sodium hydroxide solution adjust pH value to 7.0, by hyaluronate sodium, trehalose with water for injection dissolve after
Joining mix homogeneously in swelling good Carbomer 940NF, obtain skin-care gel substrate, autoclave sterilization is stand-by after processing, its
Middle autoclave sterilization processing procedure temperature controls in the range of 120～123 DEG C, and Stress control is in 0.1～0.12Mpa scope
In, the time controls in the range of 15～30min；
B) composite growth factor stock solution is prepared: use the mode of biofermentation purification to respectively obtain rh-bFGF and KGF, press
Proportioning raw materials and mass percent add the phosphate buffer mix homogeneously that concentration is 20mmol/L, prepare composite growth because of
Sub-stock solution, the most stand-by；
C) finished product is prepared: after being dissolved by heparin sodium water for injection by raw materials quality percentages, join answering of step b)
Close in somatomedin stock solution, then filtration after mixture is mixed with mannitol, sodium chloride, Dextran 40 lysate, by gained
Filtrate joins in the skin-care gel substrate of step a) and stirs, and subpackage obtains finished product.
Whole preparation process temperature controls in the range of 20～30 DEG C, and finally preparing gel granularity is 0.1～100 μ
M, pH value is the skin-care gel of 6.5～7.5 simultaneously.
Embodiment 2
A kind of composite growth factor skin-care gel, it includes following raw material components by mass percentage:
Wherein the effective ingredient in composite growth factor stock solution is rh-bFGF:KGF=1:1.Composite growth factor stock solution is pressed
Mass percent includes that the composite growth factor effective ingredient of 0.6% and the phosphate that concentration is 150mmol/L of surplus delay
Rush liquid.Heparin sodium is 1:1～3 with the mass ratio of composite growth factor effective ingredient in composite growth stock solution simultaneously.
Preparation method:
A) prepare skin-care gel substrate: weigh Carbomer 940NF by raw materials quality percentages, add water for injection and make it
The most swelling, add 4% sodium hydroxide solution adjust pH value to 7.0, by hyaluronate sodium, trehalose with water for injection dissolve after
Joining mix homogeneously in swelling good Carbomer 940NF, obtain skin-care gel substrate, autoclave sterilization is stand-by after processing, its
Middle autoclave sterilization processing procedure temperature controls in the range of 120～123 DEG C, and Stress control is in 0.1～0.12Mpa scope
In, the time controls in the range of 15～30min；
B) composite growth factor stock solution is prepared: use the mode of biofermentation purification to respectively obtain rh-bFGF and KGF, press
Proportioning raw materials and mass percent add the phosphate buffer mix homogeneously that concentration is 150mmol/L, prepare composite growth
Factor stock solution, the most stand-by；
C) finished product is prepared: after being dissolved by heparin sodium water for injection by raw materials quality percentages, join answering of step b)
Close in somatomedin stock solution, then filtration after mixture is mixed with mannitol, sodium chloride, Dextran 40 lysate, by gained
Filtrate joins in the skin-care gel substrate of step a) and stirs, and subpackage obtains finished product.
Whole preparation process temperature controls in the range of 20～30 DEG C, and finally preparing gel granularity is 0.1～100 μ
M, pH value is the skin-care gel of 6.5～7.5 simultaneously.
Embodiment 3
A kind of composite growth factor skin-care gel, it includes following raw material components by mass percentage:
Wherein the effective ingredient in composite growth factor stock solution is rh-bFGF:KGF=1:1.Composite growth factor stock solution is pressed
Mass percent includes that the composite growth factor effective ingredient of 0.3% and the phosphate that concentration is 150mmol/L of surplus delay
Rush liquid.Heparin sodium is 1:1～3 with the mass ratio of composite growth factor effective ingredient in composite growth stock solution simultaneously.
Preparation method:
A) prepare skin-care gel substrate: weigh Carbomer 940NF by raw materials quality percentages, add water for injection and make it
The most swelling, add 4% sodium hydroxide solution adjust pH value to 7.0, by hyaluronate sodium, trehalose with water for injection dissolve after
Joining mix homogeneously in swelling good Carbomer 940NF, obtain skin-care gel substrate, autoclave sterilization is stand-by after processing, its
Middle autoclave sterilization processing procedure temperature controls in the range of 120～123 DEG C, and Stress control is in 0.1～0.12Mpa scope
In, the time controls in the range of 15～30min；
B) composite growth factor stock solution is prepared: use the mode of biofermentation purification to respectively obtain rh-bFGF and KGF, press
Proportioning raw materials and mass percent add the phosphate buffer mix homogeneously that concentration is 150mmol/L, prepare composite growth
Factor stock solution, the most stand-by；
C) finished product is prepared: after being dissolved by heparin sodium water for injection by raw materials quality percentages, join answering of step b)
Close in somatomedin stock solution, then filtration after mixture is mixed with mannitol, sodium chloride, Dextran 40 lysate, by gained
Filtrate joins in the skin-care gel substrate of step a) and stirs, and subpackage obtains finished product.
Whole preparation process temperature controls in the range of 20～30 DEG C, and finally preparing gel granularity is 0.1～100 μ
M, pH value is the skin-care gel of 6.5～7.5 simultaneously.
Embodiment 4: repeatedly irritation test
The present invention meets the indices in " cosmetics health specification " (2007 editions) of country's promulgation, without any poisonous
Material, has no side effect.Repeatedly irritation test method therein is according to " skin in " cosmetics health specification " (2007 editions)
Zest/corrosion test " relevant regulations carries out.Specifically, embodiment 1 preparation-obtained composite growth factor skin protection is selected
Gel is as tested material；Select the skin-care gel substrate in embodiment 1 as tester；Select white big ear rabbit dynamic as experiment
Thing.Its test result such as table 1 below:
Table 1 skin-care gel is to white big ear rabbit repeatedly irritation test result
Understanding according to " skin irritation strength grading ", the composite growth factor skin-care gel prepared by the present invention not only accords with
Close " cosmetics health specification " (2007 editions) regulation about skin irritation, and this composite growth factor skin-care gel character
Gentleness, nonirritant, skin repair can be used as a long time and nursing uses.
Embodiment 5: application measure of merit
(1) Zhang, 34 years old, life-time service treated acne containing Hormonal ointment, caused skin senilism, withered nonelastic, wrinkle
Increase, facial skin red blood streak obvious, stop using containing appealing exacerbation of symptoms after Hormonal ointment；Other treatment is now stopped using to use
Product and cosmetics, be early later than after washing one's face product of the present invention is softly applied in facial skin every day, after using one week, and the red blood of face
Silk is improved, and after two weeks, red blood streak improves substantially, and wrinkle reduces, and it is flexible that skin starts to become gloss, uses January continuously
Rear red blood streak disappears, and face wrinkles is inconspicuous, and skin gloss is flexible.
(2) money, 47 years old, both legs skin occurred that erythema, red point, a large amount of scurf come off, are dried pruritus；Every day incite somebody to action this sooner or later
Invention product is softly applied in both legs skin, every day twice, is dried pruritis and substantially alleviates after using one day, and decortication symptom subtracts
Gently, red some erythema starts to disappear, and after using one week continuously, both legs skin, without dry pruritis, comes off without scurf, the red point of erythema
Disappearing, skin recovers normal skin tone.
(3) grandson, 38 years old, life-time service cosmetics, the colour of skin was dark and gloomy, cutis laxa, corse sweat pore, xerosis cutis；Every day
Sooner or later after washing one's face, product of the present invention being softly applied in facial skin, every day twice, after using one week, skin moisturizing is glossy,
Flexible, corse sweat pore symptom substantially alleviates, and after using 3 weeks continuously, skin-tightening exquisiteness is flexible.
(4) Wang, 43 years old, makes up for a long time, and facial skin is rubescent, pruritus；Sooner or later by light for product of the present invention after washing one's face every day
The soft facial skin that is applied in, every day twice, after using one week, rubescent pruritis alleviates, and after using three weeks continuously, skin recovers
Normal skin tone, without pruritis.
(5) week certain, 35 years old, red swelling of the skin pain, during caloric stimulation, the pain increased；Sooner or later after washing one's face every day, the present invention is produced
Product are softly applied in year not skin, every day twice, and after using one week, red swelling of the skin disappears substantially, and pain relief uses three continuously
Zhou Hou, red swelling of the skin disappears completely, without pain during caloric stimulation.
Above-described embodiment is the preferred embodiments of the present invention, all technique similar with the present invention and the equivalence change made,
The protection category of the present invention all should be belonged to.
Claims (9)
1. a composite growth factor skin-care gel, it is characterised in that include following raw material components by mass percentage:
Composite growth factor stock solution 1 ~ 50%
Carbomer 940NF 0.5 ~ 1.5%
4% sodium hydroxide solution 1 ~ 10%
Hyaluronate sodium 0.1 ~ 2%
Trehalose 0.1 ~ 10%
Mannitol 1 ~ 10%
Sodium chloride 0.85-0.95%
Dextran 40 0.1 ~ 5%
Heparin sodium 0.00003 ~ 0.3%
Water for injection surplus；
Wherein the effective ingredient in composite growth factor stock solution is rh-bFGF:KGF=1:0.6 ~ 1.
A kind of composite growth factor skin-care gel the most according to claim 1, it is characterised in that described composite growth factor
Stock solution includes following component by mass percentage:
Composite growth factor effective ingredient 0.0001 ~ 0.6%
Phosphate buffer surplus.
A kind of composite growth factor skin-care gel the most according to claim 2, it is characterised in that described phosphate buffer
Concentration be 20 ~ 200 mmol/L.
A kind of composite growth factor skin-care gel the most according to claim 2, it is characterised in that described heparin sodium is with compound
In growth stock solution, the mass ratio of composite growth factor effective ingredient is 1:1 ~ 3.
A kind of composite growth factor skin-care gel the most according to claim 1, it is characterised in that gel granularity is 0.1 ~
100µm。
A kind of composite growth factor skin-care gel the most according to claim 1, it is characterised in that the pH value of gel is 6.5 ~
7.5。
7. the preparation method of the composite growth factor skin-care gel as described in any one of claim 1 ~ 6, it is characterised in that
Comprise the steps:
A) prepare skin-care gel substrate: weigh Carbomer 940NF by raw materials quality percentages, add water for injection and make it natural
Swelling, add 4% sodium hydroxide solution adjust pH value to 7.0, by hyaluronate sodium, trehalose with water for injection dissolve after add
Mix homogeneously in swelling good Carbomer 940NF, obtains skin-care gel substrate, and autoclave sterilization is stand-by after processing；
B) composite growth factor stock solution is prepared: use the mode of biofermentation purification to respectively obtain rh-bFGF and KGF, by raw material
Proportioning and mass percent add phosphate buffer mixing, prepare composite growth factor stock solution, the most stand-by；
C) finished product is prepared: after being dissolved by heparin sodium water for injection, join the compound life of step b) by raw materials quality percentages
In long factor stock solution, then filter after mixture is mixed with mannitol, sodium chloride, Dextran 40 lysate, by gained filtrate
Join in the skin-care gel substrate of step a) and stir, subpackage, obtain finished product.
The preparation method of a kind of composite growth factor skin-care gel the most according to claim 7, it is characterised in that prepared
In journey, temperature controls in the range of 20 ~ 30 DEG C.
The preparation method of a kind of composite growth factor skin-care gel the most according to claim 7, it is characterised in that step a)
Described in autoclave sterilization processing procedure temperature control in the range of 120 ~ 123 DEG C, Stress control is at 0.1 ~ 0.12Mpa model
In enclosing, the time controls in the range of 15 ~ 30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610380847.6A CN106038350A (en) | 2016-05-31 | 2016-05-31 | Composite growth factor skincare gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610380847.6A CN106038350A (en) | 2016-05-31 | 2016-05-31 | Composite growth factor skincare gel and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106038350A true CN106038350A (en) | 2016-10-26 |
Family
ID=57172573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610380847.6A Pending CN106038350A (en) | 2016-05-31 | 2016-05-31 | Composite growth factor skincare gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106038350A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078805A (en) * | 2017-12-29 | 2018-05-29 | 广西大学 | Preserving moisture and protecting skin water and preparation method thereof |
| CN108721136A (en) * | 2018-07-04 | 2018-11-02 | 广州领衔生物科技有限公司 | Maintenance gel and its preparation method and application |
| CN108743448A (en) * | 2018-08-30 | 2018-11-06 | 吉林省星空生物集团有限公司 | A kind of biological prosthetic facial mask and preparation method thereof |
| JP2020533015A (en) * | 2017-06-23 | 2020-11-19 | 珠海億勝生物製薬有限公司 | A pharmaceutical composition containing recombinant human basic fibroblast growth factor (rh-bFGF) and rh-bFGF. |
| CN112043625A (en) * | 2020-09-16 | 2020-12-08 | 广州因码生物科技有限公司 | Spray capable of entering eyes and containing growth factor activity protection technology |
| CN112569346A (en) * | 2019-09-29 | 2021-03-30 | 国家卫生健康委科学技术研究所 | Hydrogel for promoting wound healing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265268A1 (en) * | 2001-08-18 | 2004-12-30 | Deepak Jain | Compositions and methods for skin rejuvenation and repair |
| CN1733294A (en) * | 2005-08-10 | 2006-02-15 | 南海朗肽制药有限公司 | Recombined human alkaline fibroblast growth factor gelling agent and process for preparing the same |
| CN101518503A (en) * | 2008-02-26 | 2009-09-02 | 漳州沛美化妆品有限公司 | Novel cosmetic based on growth factor and serine |
-
2016
- 2016-05-31 CN CN201610380847.6A patent/CN106038350A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040265268A1 (en) * | 2001-08-18 | 2004-12-30 | Deepak Jain | Compositions and methods for skin rejuvenation and repair |
| CN1733294A (en) * | 2005-08-10 | 2006-02-15 | 南海朗肽制药有限公司 | Recombined human alkaline fibroblast growth factor gelling agent and process for preparing the same |
| CN101518503A (en) * | 2008-02-26 | 2009-09-02 | 漳州沛美化妆品有限公司 | Novel cosmetic based on growth factor and serine |
Non-Patent Citations (2)
| Title |
|---|
| 叶朝辉等: "细胞因子及其在化妆品中的应用", 《中国生物美容》 * |
| 董文波: "《农民健康教育知识问答》", 31 August 1999, 贵州科技出版社 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020533015A (en) * | 2017-06-23 | 2020-11-19 | 珠海億勝生物製薬有限公司 | A pharmaceutical composition containing recombinant human basic fibroblast growth factor (rh-bFGF) and rh-bFGF. |
| EP3643784A4 (en) * | 2017-06-23 | 2021-05-05 | Zhuhai Essex Bio-pharmaceutical Co., Ltd. | Recombinant human-basic fibroblast growth factor (rh-bfgf) and pharmaceutical composition comprising rh-bfgf |
| US11254723B2 (en) | 2017-06-23 | 2022-02-22 | Zhuhai Essex Bio-Pharmaceutical Co., Ltd. | Recombinant human-basic fibroblast growth factor (rh-bFGF) and pharmaceutical composition comprising rh-bFGF |
| JP7044870B2 (en) | 2017-06-23 | 2022-03-30 | 珠海億勝生物製薬有限公司 | A pharmaceutical composition containing recombinant human basic fibroblast growth factor (rh-bFGF) and rh-bFGF. |
| CN108078805A (en) * | 2017-12-29 | 2018-05-29 | 广西大学 | Preserving moisture and protecting skin water and preparation method thereof |
| CN108721136A (en) * | 2018-07-04 | 2018-11-02 | 广州领衔生物科技有限公司 | Maintenance gel and its preparation method and application |
| CN108743448A (en) * | 2018-08-30 | 2018-11-06 | 吉林省星空生物集团有限公司 | A kind of biological prosthetic facial mask and preparation method thereof |
| CN112569346A (en) * | 2019-09-29 | 2021-03-30 | 国家卫生健康委科学技术研究所 | Hydrogel for promoting wound healing and preparation method thereof |
| CN112043625A (en) * | 2020-09-16 | 2020-12-08 | 广州因码生物科技有限公司 | Spray capable of entering eyes and containing growth factor activity protection technology |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106038350A (en) | Composite growth factor skincare gel and preparation method thereof | |
| CN102935055B (en) | Hydrolat moisturizing facial mask | |
| CN106309154A (en) | Skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate | |
| KR100721144B1 (en) | Cosmetic composition for caring wrinkle containing peptide combination | |
| CN101791283B (en) | Cosmetic capable of eliminating striae gravidarum and scars | |
| CN104825382A (en) | Biotechnology skin-whitening cosmetics | |
| CN106176556A (en) | A kind of removing acnes and controlling oil whitening cream | |
| CN103006460A (en) | Skin-caring composition and preparation method and applications thereof | |
| JP2022550136A (en) | Composition and its use in the manufacture of skin care products for regulating skin biorhythms | |
| CN108619059A (en) | A kind of bright face Face-protecting mask liquid and preparation method thereof | |
| CN107296764A (en) | Cream and preparation method thereof | |
| CN104887542B (en) | A cosmetic composition | |
| CN108309817A (en) | A kind of whitening mask Essence and preparation method thereof using resveratrol | |
| CN114042001A (en) | Whitening composition with synergistic effect and application thereof | |
| CN113081879A (en) | Black eye and pouch removing composition as well as preparation method and application thereof | |
| CN108143644A (en) | A kind of preparation method for raw material in skin care item | |
| CN104814916A (en) | Moisturizing essence and preparing method thereof | |
| CN102058513A (en) | Chinese herbal medicine crude solution and cosmetic containing same | |
| CN108703911B (en) | Composition with moisturizing and whitening effects and preparation method and application thereof | |
| CN114569491B (en) | Composition for inhibiting grease generation and application thereof | |
| CN105963188A (en) | Allergy-relieving moistening toner containing gynostemma saponin and preparation method thereof | |
| CN108272677A (en) | A kind of moistening and whitening facial mask and preparation method thereof containing plant extracts | |
| CN106821932A (en) | A kind of cosmetics containing west safflower extract solution | |
| CN110302064B (en) | Whitening and moisturizing essence and whitening and moisturizing mask prepared from same | |
| CN108852977B (en) | Crystal moistening essence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
|
| RJ01 | Rejection of invention patent application after publication |