CN101518503A - Novel cosmetic based on growth factor and serine - Google Patents
Novel cosmetic based on growth factor and serine Download PDFInfo
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- CN101518503A CN101518503A CN200810007857A CN200810007857A CN101518503A CN 101518503 A CN101518503 A CN 101518503A CN 200810007857 A CN200810007857 A CN 200810007857A CN 200810007857 A CN200810007857 A CN 200810007857A CN 101518503 A CN101518503 A CN 101518503A
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Abstract
The invention provides a novel cosmetic based on growth factor and serine. The cosmetic consists of epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, serine and cosmetic substrate. Three growth factors play effects corporately, additionally, the serine is a natural moisture factor, thus quickening the metabolism of the skin, whitening and moisturizing, tenderizing skin, removing freckles and wrinkles, preventing skin from ageing, increasing the elasticity of skin, repairing the damaged skin and comprehensively improving the whole condition of skin.
Description
Technical field
The invention belongs to cosmetics research and development field.Relate to a kind of novel cosmetic based on somatomedin and serine, it can promote skin regeneration and improve skin matter.
Background technology
Along with the raising day by day of people's living standard, people more and more pay attention to the personal image of oneself, and market survey finds, the women make apply some make up in to the degree of concern maximum of quality and effect.Therefore, the high-tech that development quality is good, result of use the is good product of making up are directions of cosmetic field research and development.
Along with the variation at age, the various 26S Proteasome Structure and Functions of skin are also changing.The invasion and attack of environment, particularly long-term sun exposure, more much bigger to the damage of skin more than age ageing.
Following variation appears in skin texture, physiology, the biochemical increase with the age: (1) 70 years old and comparison in 30 years old, the cell conversion ratio approximately reduces 50% in the epidermis, corium purport power fiber and collagen fiber all reduce, the reason that characteristic that the apparent pattern of the skin of aging that Here it is is thin and Clear ﹠ Transparent and corium blood vessel are easy to rupture.(2) along with the age change is big, collagen fiber and elastic fibers become connection and increase, but make the corium tropism weaker, thereby the lear energy reduction, and when skin is pinched time-out, old people's skin slowly restores to the original state.Elastic tissue degeneration causes wrinkle to be deepened.(3) melanocyte enzymatic activity attenuating (per 10 years attenuating 10-20%) causes the irregular pigmentation of skin, and hair becomes canescence.
(growth factor is to have the active cytokine of stimulating cellular growth GF) to somatomedin, and being a class, cell is grown and the polypeptides matter of manifold effects such as other cell functions by combine, regulates with special, high affine cell-membrane receptor.Be present in platelet and various adult and embryonal tissue and the most of cultured cell, the variety classes cell is had certain specificity.Generalized somatomedin has multiple, as insulin, epidermal growth factor (EGF), fibroblast growth factor (fibroblastgfowth factor, FGF), platelet source reproduction factor (platelet-derivedgrowthfactor, PDGF) and somatostatin (somatostatin=SRIH), hydrocortisone, thyroxine etc.The somatomedin of human body has multiple physiological action, can promote growth, reparation and the extra-nutrition of cell.Because when injured, disease or old and feeble former thereby sustain damage, the human growth element is that the stimulating growth factor produces, these somatomedin are promptly as fire brigade rush " fire fighting " when tissue.In numerous somatomedin, some has special effect to skin, is particularly suitable for being applied to the development of cosmetics.
Epidermal growth factor (Epidermal Growth Factor, EGF) be the intravital a kind of cytokine of forming by 53 aminoacid of machine, extensively be present in many histoorgans and the body fluid, can promote the growing multiplication of epithelial cell, fibroblast, vascular endothelial cell, physiological function is widely arranged.It is equaled to find in 1962 by U.S. scientist Stanley Cohen, and therefore wins Nobel's medical science in 1986 and encourage with the physiology.A large amount of scientific experimentss show: epidermal growth factor can promote the healing of skin trauma, has also shown wide application prospect at aspects such as treatment gastrointestinal ulceration, corneal injury, the perforation of ear drum, fracture, acute tubular damage and cancers.In addition, epidermal growth factor still is a kind of good cosmetics additive, also can be used as the interpolation composition of serum-free medium.Epidermal growth factor is former to extract from urine.Because raw material is collected difficulty, effective component content is low in the raw material, reasons such as extraction process complexity, and the extensive use of epidermal growth factor is restricted.Engineered high-tech means has been arranged, and the highly purified epidermal growth factor of mass production has become reality.Epidermal growth factor is the inherent protein of a kind of human body, plays the epidermis of repairing damage in vivo, promotes the effect of wound healing.Add epidermal growth factor in the cosmetics, can play wrinkle removing, go effect such as abnormal pigmentary deposit on the skin, increase skin elasticity, make skin smooth U.S. clean tender white.
Keratinocyte growth factor (Keratinocyte growth factor, KGF) be that known short keratinocyte (KC) is bred the strongest cytokine at present, albumen is made up of 194 aminoacid, and its gene contains three exons, two introns are a kind of mitogenic factors.KGF plays an important role in the growth of epidermis cell and renewal process, can accelerate the injury repairing and the growth of short people's corneal epithelial cell of bladder, kidney and intestinal.In addition, KGF is being put, is also being played an important role aspect the injury repairing that chemotherapy is brought.Continuous development along with keratinocyte growth factor research and application has been applied to cosmetic field, mainly acts on the horn cell of skin surface, and mucomembranous epithelial cell and fibrocyte are had certain effect.Confirmed that KGF comprises the function of the horn cell of skin: 1) promote skin keratin hyperplasia; 2) differentiation successively of promotion horn cell; 3) promoting horn cell eccrine fiber albumen such as collagen protein, 4) the shielding angle cell plastid is not subjected to the damage of extraneous factor such as ultra-vioket radiation.These effects prevent skin aging for the eubolism of skin, keep elasticity and skin smooth and fine and softly play crucial effect.
(fibroblast growth factor in early days mainly from Medulla Bovis seu Bubali and extracting solution pituitary, is the acidity or the basic fibroblast growth factor of about 150 amino acid structures FGF) to fibroblast growth factor.The nineties, use gene engineering method successfully to obtain the FGF that recombinates both at home and abroad in succession.Present known fibroblast growth factor has 23 kinds, i.e. FGF1～23.Fibroblast growth factor can be by endotheliocyte, smooth muscle cell, macrophage secretion.Its effect is to promote the migration of endotheliocyte and the propagation of smooth muscle cell, can not make the smooth muscle cell migration.Can promote neovascularization, repair the endotheliocyte of infringement.
Serine is being brought into play in the growth of fat and the metabolism of fatty acid and muscle and is being acted on, because it helps immunoglobulin and production of antibodies, the immune system of keeping health also needs serine.Serine is all being brought into play in the sheath of manufacturing processing, muscular tissue and the encirclement neurocyte of cell membrane synthetic and is being acted on.Serine can obtain from Semen sojae atricolor, brewing fermentation agent, milk product, egg, fish, lactalbumin, soybean pod, meat, nut, seafood, seed, Semen sojae atricolor, milk surum and whole wheat.Be necessary that the people knows from experience synthetic serine from glycine.Serine is the important amino acid in the nature moisturizing factor in cosmetics, and when skin cell product crack was big, moisture was just lost easily.Make the skin superficial drying coarse, even produce little microgroove, and serine can form moisture film in skin surface immediately, the barrier skin prevents water loss.Simultaneously, serine and glycine metabolite also have anti-sunlight function.
Along with the continuous development of cosmetics new raw material, new technique, new equipment, somatomedin and serine are applied in the cosmetics.But do not see that with epidermal growth factor, keratinocyte growth factor and fibroblast growth factor and serine common application in same cosmetics, collaborative playing a role improved the report and the application of skin matter better.The present invention according to certain proportioning, adopts modern crafts to make cosmetics these several active substances, and multi-efficiency promotes skin regeneration and improves skin matter.
Summary of the invention
The purpose of this invention is to provide a kind of metabolism that passes through three kinds of somatomedin and serine promotion skin, whitening skin and preserving moisture, tenderization skin, the speckle dispelling reduce wrinkle prevents skin aging, increases skin elasticity, repair impaired skin, improve the cosmetics of skin integral status comprehensively.These cosmetics are made up of epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, serine and cosmetic base, when three kinds of somatomedin and serine combined effect during in skin, wherein epidermal growth factor can promote reepithelialization, repair the defect table chrotoplast, and can play wrinkle removing, go effects such as abnormal pigmentary deposit on the skin, increase skin elasticity, make skin smooth U.S. clean tender white; Keratinocyte growth factor can promote skin keratin hyperplasia, promote horn cell eccrine fiber albumen such as collagen protein, the shielding angle cell plastid is not subjected to the damage of extraneous factor such as ultra-vioket radiation, keep the eubolism of skin, prevent skin aging, keep elasticity and skin smooth and fine and soft; Fibroblast growth factor can promote neovascularization, microcirculation improvement, and can repair the endotheliocyte of infringement; Serine is natural Moisture factor, and has anti-sunlight function.Each active component synergism in these cosmetics, the nutritional labeling in the cosmetic base in addition, thus reach the purpose that promotes skin regeneration and improve skin matter.
The present invention realizes with following technical scheme:
The present invention is based on the cosmetics that somatomedin and serine can improve skin matter, is made up of epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, serine and cosmetic base.When several active substance combineds effect during, can work in coordination with and promote skin regeneration and improve skin matter skin.
Novel cosmetic of the present invention and manufacturing process thereof:
The epidermal growth factor, keratinocyte growth factor, fibroblast growth factor and the serine that add corresponding proportion in the novel cosmetic of the present invention, be equipped with corresponding substrate adjuvant and mix, emulsifying, sterilization, fill is a different dosage form, the cosmetics of different efficacies.
Above-mentioned epidermal growth factor results from genetic engineering, and its place mainly contains escherichia coli, bacillus subtilis, bacillus brevis, yeast, cyanophyceae and Nicotiana tabacum L..Wherein preferably obtain epidermal growth factor for the host gene engineering with escherichia coli.
Above-mentioned keratinocyte growth factor is by escherichia coli expression and preparation, or the recombinant expressed and preparation by escherichia coli, comprise keratinocyte growth factor-I, keratinocyte growth factor-II, the isomer of recombined new human keratinized cell, keratinocyte growth factor analog, Novel Human horny cell growth factor-2 mutant.Wherein preferred keratinocyte growth factor-II.
Above-mentioned fibroblast growth factor is acid fibroblast growth factor (aFGF:FGF1) and the basic fibroblast growth factor (bFGF:FGF2) that comes from Medulla Bovis seu Bubali and hypophysis cerebri extracting solution, and is that the fibroblast growth factor hypotype that host's genetic engineering obtains comprises FGF3～23 with multiple animal thereafter.Wherein preferred bFGF.
It is synthetic that above-mentioned silk amino acid derives from the artificial bio-membrane, or extract from plant, animal etc., comprises Semen sojae atricolor, brewing fermentation agent, milk product, egg, fish, lactalbumin, soybean pod, meat, nut, seafood, seed, milk surum and whole wheat etc.The wherein preferred silk amino acid that makes that from Semen sojae atricolor, extracts.
Above-mentioned cosmetic base can be one or more in softening agent, wetting agent, emulsifying agent, thickening agent, antiseptic, spice, antioxidant, nertralizer, surfactant, wax, sunscreen, vitamins, crease-resistant active component, the Chinese medicine extract.
Above-mentioned substrate is identical with the component that existing cosmetics use basically.For example use stearic acid, silicone oil, dimethyl siloxanes etc. are made softening agent, use glycerol, hyaluronic acid, Semen Tritici aestivi germ oil, propylene glycol etc. are made wetting agent, use hexadecanol, octadecanol, glyceryl monostearate, Calcium Disodium Versenate, octadecane oxygen base trimethyl silane (with) stearyl alcohol, aluminum starch succinic acid octene ester etc. is made emulsifying agent, use hydroxyethyl-cellulose, white oil, xanthan gum, castor oil hydrogenated, myristic acid octyldodecanol ester etc. is made thickening agent, use Bronopol, methyl hydroxybenzoate, propylparaben etc. are made antiseptic, use green tea essence etc. is made spice, uses the VE acetas to make antioxidant; Use extracting solution such as Radix Panacis Quinquefolii, Flos Carthami, Herba Menthae to be Chinese medicine extract etc.The consumption of each composition also is same as existing cosmetics substantially in the substrate.
Novel cosmetic host of the present invention, substrates quantity scope by weight percentage:
(1) epidermal growth factor 0.5-2ppm
(2) keratinocyte growth factor 1-100ppm
(3) desmocyte growth factor-21-100ppm
(4) serine 1-5
(5) cosmetic base 1-90
(6) sterilized water adds to 100
The host of product of the present invention, substrates quantity preferable range by weight percentage is:
(1) epidermal growth factor 1-1.5ppm
(2) keratinocyte growth factor 50-80ppm
(3) fibroblast growth factor 50-80ppm
(4) serine 2-3
(5) softening agent 1～30
(6) wetting agent 2～10
(7) emulsifying agent 0.1～20
(8) thickening agent 0.1～20
(9) antiseptic 0.01～3
(10) essence 0.1～5
(11) sterilized water adds to 100
Also can contain other components of cosmetics commonly used, as: nertralizer, surfactant, wax, sunscreen, vitamins, crease-resistant active component etc.
The present invention with epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, serine common application in cosmetics, with other biological beauty active substance such as vitamin C and hyaluronic acid etc., corresponding preparation technology by cosmetics, make cream, emulsion or water preparation, reach whitening skin and preserving moisture, tenderization skin, speckle dispelling reduce wrinkle, prevent skin aging, increase skin elasticity, repair impaired skin, improve the effect of attacking of skin integral status comprehensively.
Observe by research, a kind of novel cosmetic based on somatomedin and serine of the present invention has and improves the skin effect preferably.For the ease of effect and the safety of understanding this novel cosmetic, the inventor adopts this novel cosmetic of embodiment 1 method preparation to carry out following experimental study:
Test example 1 whitening and speckle dispelling effect experimentation
Get 10 of New Zealand white rabbit, male and female half and half, body weight 2,5-3,5kg all shave hair in the both sides, back, unhairing district size is 10cm * 5cm, be coated with in both sides behind the 24h and put psoralea tincture (increasing the speckle agent) on the skin, every day 2 times, every day sun exposure 2h, during accumulation sun exposure 24h, white rabbit skin both sides form obvious mottle, and during this period, white rabbit is shaved 1 time/3d of hair.Adopt self-controlled method, increase speckle rabbit body left side in 9 and smear novel cosmetic based on somatomedin and serine, the blank substrate of emulsifiable paste is smeared on the right side, every day 2 times, remains 1 as positive control.Analyze after 20 days and to situation of change.Special produce effects: skin pigment spot obviously disappears; Produce effects: skin pigment spot disappears more than 1/2; Effectively: skin pigment spot disappears more than 1/4; Invalid: skin pigment spot does not have obvious change.
Result of the test shows, based on the novel cosmetic of somatomedin and serine whiten the class of dispelling effective percentage be 88.9%, the matched group effective percentage is 11.1%.(seeing Table 1)
Table 1 is based on the novel cosmetic whitening and speckle dispelling effect experimental studies results of somatomedin and serine
Test example 2 skin texture test experiments
Use the novel cosmetic based on somatomedin and serine to carry out the skin texture test, the skin index changes as shown in table 2ly before and after smearing, and test result shows, uses this product can obviously improve skin texture after 4 hours.
Table 2 is based on the novel cosmetic skin texture test result of somatomedin and serine
The check of test example 3 safety evaluatio toxicology
For guaranteeing the safety of this product, it is as follows to carry out repeatedly skin irritation test:
Selecting body weight for use is 6 of the healthy adult new zealand rabbits of 2.0-2.4kg, at temperature 20-30 degree centigrade, under the condition of relative humidity 50%-70%, will be tried thing and be applied to rabbit back cropping place, is coated with skin every day 1 time, is coated with skin continuously 12 days.Test shows, tried thing repeatedly skin irritation every animal integral mean value test every day be 0.04, belong to nonirritant according to " cosmetics health standard " skin irritation strength grading, illustrate based on the novel cosmetic of somatomedin and serine non-stimulated to skin.(seeing Table 3)
Table 3 is based on the novel cosmetic skin irritation test of somatomedin and serine
The specific embodiment
Describe the enforcement of technical solution of the present invention by the following examples in detail, but should not limit practical range of the present invention with this.Generally the equalization of being done according to the present patent application claim changes and modifies, promptly in various cosmetics, add epidermal growth factor, keratinocyte growth factor, fibroblast growth factor, serine jointly, the different prescriptions that make, the cosmetics of different dosage form all should still belong in the scope that patent of the present invention contains.
Embodiment 1: the whitening skin and preserving moisture emulsion that contains EGF, KGF, FGF and serine
This embodiment is one of best prescription of product of the present invention, is the whitening skin and preserving moisture emulsion that is fit to any skin matter, and consumption is remembered by weight percentage.
Prescription: (quality %)
First component (oil phase moisture):
16/octadecanol 1.5
Glyceryl monostearate 2.5
White oil 10.0
Silicone oil DC-200 5.0
Emulsifying agent 72 2.0
Emulsifying agent 721 2.5
Myristic acid isopropyl ester 3
Mud is moored golden third fat 0.05
Second component (water-phase component):
Epidermal growth factor 1ppm
Keratinocyte growth factor 55ppm
Fibroblast growth factor 60ppm
Serine 2.5
Glycerol 6
Vitamin C 0.6
QM thickening agent 0.1
Mud pool tortoise beetle fat 0.2
The sterilized water surplus
Third component:
Essence 0.5
Antiseptic 0.3
Preparation process: the first component is heated to 95 ℃ makes oil phase, second component water is added the dissolving of QM thickening agent heated and stirred, temperature to 95 ℃, all the other B are heated to 95 ℃ at large water tank, the large water tank sucking filtration is advanced reaction pot, A is filtered into reaction pot, then QM thickening agent water liquid is filtered into reaction pot, even matter 3 minutes makes its complete emulsifying.When slowly cooling is cooled to 40-50 ℃, add third component, stir evenly postcooling to room temperature.Under aseptic condition, carry out packing.
Embodiment 2: the spot removing skin softening frost that contains EGF, KGF, FGF and serine
This embodiment is one of best prescription of product of the present invention, is the spot removing skin softening frost that is fit to any skin matter, and consumption is remembered by weight percentage.
Prescription: (quality %)
First component (oil phase moisture):
Triple pressed stearic acid 4
Glyceryl monostearate 1.5
White oil 3
Silicone oil DC-200 0.5
Peregal 01
Lanoline 4
Myristic acid isopropyl ester 3
Mud is moored golden third fat 0.1
Second component (water-phase component):
Epidermal growth factor 1.2ppm
Keratinocyte growth factor 60ppm
Fibroblast growth factor 60ppm
Serine 3
Hyaluronic acid 0.3
Vitamin E 0.2
Mud pool tortoise beetle fat 0.25
The sterilized water surplus
Third component:
Essence 0.5
Antiseptic 0.3
Preparation process: the first component is heated to 95 ℃ makes oil phase, the second component is heated to 95 ℃ makes water, the first component slowly is added in third component, even matter 5 minutes, add third component when constantly stirring is cooled to 40-50 ℃, be chilled to the room temperature discharging, under aseptic condition, carry out packing.
Embodiment 3: the crease-resistant stricture of vagina essence that removes that contains EGF, KGF, FGF and serine
This embodiment is one of best prescription of product of the present invention, is the crease-resistant stricture of vagina essence that removes that is fit to any skin matter, and consumption is remembered by weight percentage.
Prescription: (quality %)
The first component:
Polyoxyethylene octadecyl ether 1.7
Triglyceride 0.05
Vitamin A palmitate 0.01
Stearic acid 0.02
1-3-butanediol 4
Hydrogenation soybean phospholipid 1
The second component:
Epidermal growth factor 1.5
Keratinocyte growth factor 80
Fibroblast growth factor 75
Serine 5
Glycerol 2
L-ascorbic acid sodium sulfate 1
Sodium citrate 0.05
Ethanol 3
Polyoxypropylene diglycerol 1
Acetylglutamate 0.3
Spherical nylon powder 1
The sterilized water surplus
Third component:
Essence 0.5
Antiseptic 0.3
Preparation process: at 85 ℃ of mixed dissolutions, 85 ℃ of heating, the limit is fully stirred to wherein adding the first component in the limit with second component sterilized water with the first component, and corpusculed is carried out by high-pressure homogenizer in the cooling back.The second component is dissolved in mixed at room temperature, and the first component with corpusculed adds wherein again, adds third component at last, stirs evenly postcooling to room temperature.Under aseptic condition, carry out packing.
Claims (10)
1. based on the novel cosmetic of somatomedin and serine, it is characterized in that: cosmetics contain three kinds of somatomedin, serine and cosmetic base to be formed.
2. the novel cosmetic based on somatomedin and serine according to claim 1 is characterized in that three kinds of somatomedin wherein are respectively epidermal growth factor, keratinocyte growth factor and fibroblast growth factor.
3. the novel cosmetic based on somatomedin and serine according to claim 2 is characterized in that wherein epidermal growth factor results from any or multiple in gene engineering colibacillus, bacillus subtilis, bacillus brevis, yeast, cyanophyceae or the Nicotiana tabacum L..
4. the novel cosmetic based on somatomedin and serine according to claim 2 is characterized in that wherein keratinocyte growth factor comprises any or multiple in keratinocyte growth factor-I, keratinocyte growth factor-II, the isomer of recombined new human keratinized cell, keratinocyte growth factor analog, the Novel Human horny cell growth factor-2 mutant.
5. the novel cosmetic based on somatomedin and serine according to claim 2 is characterized in that wherein fibroblast growth factor is any or multiple in acid fibroblast growth factor, basic fibroblast growth factor, fibroblast growth factor hypotype FGF3～23.
6. the novel cosmetic based on somatomedin and serine according to claim 1 is characterized in that wherein serine derives from biosynthesis or from Semen sojae atricolor, brewing fermentation agent, milk product, egg, fish, lactalbumin, soybean pod, meat, nut, seafood, seed, milk surum or whole wheat one or more to obtain.
7. the novel cosmetic based on somatomedin and serine according to claim 1 is characterized in that wherein cosmetic base is one or more in softening agent, wetting agent, emulsifying agent, thickening agent, antiseptic, spice, antioxidant, nertralizer, surfactant, wax, sunscreen, vitamins, crease-resistant active component, the Chinese medicine extract.
8. the novel cosmetic based on somatomedin and serine according to claim 1 is characterized in that cosmetic base wherein is a stearic acid, silicone oil, dimethyl siloxane, glycerol, hyaluronic acid, Semen Tritici aestivi germ oil, propylene glycol, hexadecanol, octadecanol, glyceryl monostearate, Calcium Disodium Versenate, octadecane oxygen base trimethyl silane and stearyl alcohol, aluminum starch succinic acid octene ester, hydroxyethyl-cellulose, white oil, xanthan gum, castor oil hydrogenated, myristic acid octyldodecanol ester, Bronopol, methyl hydroxybenzoate, propylparaben, green tea essence, VE acetas and Radix Panacis Quinquefolii, Flos Carthami, in the Herba Menthae extracting solution one or more.
9. according to the described novel cosmetic of claim 1～8, it is characterized in that wherein each constituent content is based on somatomedin and serine:
(1) epidermal growth factor 0.5-2ppm
(2) keratinocyte growth factor 1-100ppm
(3) desmocyte growth factor-21-100ppm
(4) serine 1-5
(5) cosmetic base 1-90
(6) sterilized water adds to 100.
10. according to the described novel cosmetic of claim 1～9, it is characterized in that comprising cream, Emulsion and the water preparation made thus based on somatomedin and serine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810007857A CN101518503A (en) | 2008-02-26 | 2008-02-26 | Novel cosmetic based on growth factor and serine |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810007857A CN101518503A (en) | 2008-02-26 | 2008-02-26 | Novel cosmetic based on growth factor and serine |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271837A (en) * | 2013-06-07 | 2013-09-04 | 王迎峰 | Formula and preparation method for bioactive cosmetic |
| CN104224567A (en) * | 2014-10-04 | 2014-12-24 | 陆振飞 | Collagen moisturizing cream |
| CN106038350A (en) * | 2016-05-31 | 2016-10-26 | 南海朗肽制药有限公司 | Composite growth factor skincare gel and preparation method thereof |
| CN113925819A (en) * | 2021-11-17 | 2022-01-14 | 陈勇 | Polypeptide factor cosmetic and preparation method thereof |
-
2008
- 2008-02-26 CN CN200810007857A patent/CN101518503A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271837A (en) * | 2013-06-07 | 2013-09-04 | 王迎峰 | Formula and preparation method for bioactive cosmetic |
| CN103271837B (en) * | 2013-06-07 | 2015-09-30 | 王迎峰 | Biological activity cosmetic formulations and preparation method thereof |
| CN104224567A (en) * | 2014-10-04 | 2014-12-24 | 陆振飞 | Collagen moisturizing cream |
| CN106038350A (en) * | 2016-05-31 | 2016-10-26 | 南海朗肽制药有限公司 | Composite growth factor skincare gel and preparation method thereof |
| CN113925819A (en) * | 2021-11-17 | 2022-01-14 | 陈勇 | Polypeptide factor cosmetic and preparation method thereof |
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Owner name: XIAMEN BLADEN TRADING COMPANY LTD. Free format text: FORMER OWNER: ZHANGZHOU PEIMEI COSMETIC CO., LTD. Effective date: 20091204 |
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Effective date of registration: 20091204 Address after: Xiamen City Siming District of Hongshan Cai Tong industrial zone to handle Yuquan company Applicant after: Xiamen Brighton Trading Co., Ltd. Address before: Gao Yang Industrial Zone, Putian Town, Yunxiao County, Zhangzhou, Fujian Applicant before: Zhangzhou Panmei Cosmetic Co., Ltd. |
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Open date: 20090902 |