CN108721136A - Maintenance gel and its preparation method and application - Google Patents
Maintenance gel and its preparation method and application Download PDFInfo
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- CN108721136A CN108721136A CN201810728038.9A CN201810728038A CN108721136A CN 108721136 A CN108721136 A CN 108721136A CN 201810728038 A CN201810728038 A CN 201810728038A CN 108721136 A CN108721136 A CN 108721136A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention provides a kind of maintenance gels and its preparation method and application, are related to technical field of skin care, which includes basic fibroblast growth factor bFGF and precursor sol；The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：1000000.Above-mentioned bFGF can keep preferable stability in body colloidal sol before this invention, after testing the problem of normal temperature state storage half a year still having preferable vigor, the existing skin-protection product of ingredient containing bFGF bad preservation at normal temperatures has been effectively relieved.The each component in precursor sol is not only able to respectively play original effect with bFGF with the use of each component simultaneously, simultaneously synergistic effect can be played between each component, its curative effect is further strengthened, existing skin care item are substantially better than for the alleviation of the symptoms such as dry skin, aging, dark yellow, color spot, small pox and allergy.
Description
Technical field
The present invention relates to technical field of skin care, more particularly, to a kind of maintenance gel and its preparation method and application.
Background technology
Early in 1940, Hoftman etc. had found that one kind can promote fibroblast to give birth in the extract of brain and hypophysis
Long substance.The object is isolated and purified within 1974, and is named as fibroblast growth factor (fibroblast growth
Factor, FGF).Subsequent people are divided into the substance for separating out a kind of very high homology therewith, since it contains more acidic amino acid
Base, isoelectric point is acid (5.6), therefore is named as aFGF (aFGF), and the FGF first found is because to acid and thermo-responsive, isoelectric point
In alkaline (9.6), then referred to as basic FGF (bFGF).
Basic fibroblast growth factor bFGF is that a kind of cation for the mitogenesis containing 155 amino acid is more
Peptide, molecular weight are 16~18.5KD.With highly purified (Bohlen, 1984) of bFGF, sequencing (Esch, 1985, Simpson,
1987) and DNA clone success (Araham, 1986, Gospodarowicz, 1984) introduces heparin-agarose aggressive pathogenic
Success.Now, we can obtain purity up to 90% or more bFGF, and thus bFGF researchs enter the new stage.
In recent years, it is that human body itself is existing it has been investigated that bFGF is a kind of fissional heparin-binding protein of rush
Normal cell secretion factor, both without drug class toxicity, also without immune response.In terms of especially bFGF is applied to beauty and skin care, tool
There is good effect, specially：(1) crease-resistant, anti-aging.BFGF can promote fibroblastic growth and development, constantly with new
Cell replace aged cells, and the microenvironment of cell growth can be improved, promote the synthesis of elastomer and collagen, it is light
Change wrinkle, makes skin high resilience, delicate skin；(2) it highlights, even skin tone.BFGF can promote senile cell to update, to drop
The content of melanin and coloured corpuscle in low Skin Cell, mitigates the calmness of skin pigment；(3) sun-proof and after-sun.bFGF
Damaged cell can be repaired rapidly, mitigated ultraviolet radiation and injured caused by skin；(4) deep layer reparation.BFGF can stimulate skin
The formation of granulation tissue and the epithelialization for promoting granulation tissue, can also adjust collagen degradation and update, so as to shorten wound healing
Time and the effect for reducing scar formation.It is repaired after can be used for newly generated acne hole, laser point spot mole, anti-acne, red blood silk
It repairs.
But by bFGF be applied to skin-protection product among there are a prodigious defects, be exactly the stability problem of bFGF.
It can be seen from the above, fibroblast growth factor bFGF is a kind of albumen being made of amino acid, at normal temperatures as protein
It is difficult to preserve for a long time, once storage temperature control is bad, is easily denaturalized, inactivates or by microbial contamination.Therefore, because bFGF
These disadvantages in application field, it is more high also to directly result in the skin-protection product price containing bFGF, it is general it is freeze-dried after
Solid state preserves, and need to seriously limit its popularization and application through redissolving when use.
Therefore, a kind of skin-protection product that can be preserved for a long time at normal temperatures of the ingredient containing bFGF is researched and developed, with slow
The problem of solving the existing skin-protection product of ingredient containing bFGF bad preservation at normal temperatures, and then reduction bFGF is in the valence of skin care application field
Lattice make it easier for by big well-established, becoming very necessary and urgent.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of maintenance gel, and the maintenance gel includes basic fibroblast life
Long factor bFGF and precursor sol；The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：
1000000.Above-mentioned bFGF can keep preferable stability in body colloidal sol before this invention, after testing in normal temperature state storage half
Still there is in year preferable vigor, the problem of existing skin-protection product of ingredient containing bFGF bad preservation at normal temperatures has been effectively relieved,
And then effectively reduce bFGF skin care application field price.
The second object of the present invention is to provide a kind of preparation method of maintenance gel, and this method is by basic fibroblast
Growth factor bFGF is added in 29~32 DEG C of colloidal sol, it is possible to prevente effectively from the problem of the albuminous degeneration of bFGF caused by high temperature,
BFGF is added at a certain temperature simultaneously can be such that bFGF is more uniformly distributed adequately to be scattered among maintenance gel.
The third object of the present invention is to provide a kind of application of maintenance gel, which can be widely applied to make
In the standby cosmetics for alleviating dry skin, aging, dark yellow, color spot, small pox and allergic symptom.
A kind of maintenance gel provided by the invention, the maintenance gel include basic fibroblast growth factor bFGF and
Precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：60~100 parts of deionized water, glycerine 1~
10 parts, 1~10 part of mannitol, 0.2~2 part of PEG/PPG-14/7 dimethyl ethers, 0.5~5 part of D-pantothenyl aleohol, glycosylglycerol 0.3-
5 parts, 0.2~0.6 part of carbomer, 0.2~0.6 part of triethanolamine,0.3~0.7 part of A91, fragrant fresh ketone 0.15~
0.5 part, 0.05~0.3 part of yeast tunning extract, 0.01~0.3 part of Sodium Hyaluronate, 0.01~0.1 part of EDETATE SODIUM
With 0.5~10 part of PBS buffer solution；
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：1000000.
Further, the precursor sol is counted in parts by weight, is mainly made of the following raw material：Deionized water 70~90
Part, 3~7 parts of glycerine, 3~7 parts of mannitol, 0.5~1.5 part of PEG/PPG-14/7 dimethyl ethers, 2~4 parts of D-pantothenyl aleohol, glycerine Portugal
2~4 parts of glucosides, 0.2~0.5 part of carbomer, 0.2~0.5 part of triethanolamine,It is 0.3~0.6 part of A91, fragrant fresh
0.2~0.4 part of ketone, 0.1~0.3 part of yeast tunning extract, 0.1~0.3 part of Sodium Hyaluronate, EDETATE SODIUM 0.02~
0.08 part and 1~8 part of PBS buffer solution.
Further, the precursor sol is counted in parts by weight, is mainly made of the following raw material：Deionized water 75~85
It is part, 4~6 parts of glycerine, 4~6 parts of mannitol, 0.8~1.2 part of PEG/PPG-14/7 dimethyl ethers, 2.5~3.5 parts of D-pantothenyl aleohol, sweet
2.5~3.5 parts of oily glucoside, 0.3~0.4 part of carbomer, 0.3~0.4 part of triethanolamine,A91 0.4~0.6
Part, 0.25~0.35 part of fragrant fresh ketone, 0.15~0.25 part of yeast tunning extract, 0.15~0.25 part of Sodium Hyaluronate,
4~6 parts of 0.04~0.06 part of EDETATE SODIUM and PBS buffer solution；
Preferably, the precursor sol is counted in parts by weight, is mainly made of the following raw material：80 parts of deionized water, glycerine 5
Part, 5 parts of mannitol, 1 part of PEG/PPG-14/7 dimethyl ethers, 3 parts of D-pantothenyl aleohol, 3 parts of glycosylglycerol, 0.4 part of carbomer, three second
0.4 part of hydramine,0.5 part of A91,0.3 part of fragrant fresh ketone, 0.2 part of yeast tunning extract, Sodium Hyaluronate
5 parts of 0.2 part, 0.05 part of EDTA- disodiums and PBS buffer solution.
Further, the yeast tunning extract is TP·Group Star。
Further, the glycosylglycerol is that the active material lattice Lay extracted in never dead grass and salt tolerant algae can mattress.
A kind of preparation method of maintenance gel provided by the invention, the described method comprises the following steps：
Precursor sol is prepared using the method for substep cooling charging first, when colloidal sol step cooling is to 29~32 DEG C, is added
Enter basic fibroblast growth factor bFGF to be sufficiently mixed uniformly, obtains maintenance gel.
Further, the substep cooling charging prepares precursor sol and includes the following steps：
(a)：85~90 DEG C will be heated to after deionized water, EDETATE SODIUM, glycerine, carbomer mixing first, subsequent homogeneous 6
15~20min is kept the temperature after~9min, obtains colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 60~65 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, three ethyl alcohol are added
Amine stirs evenly, and obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 52~54 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, PEG/PPG-14/7 dimethyl ethers
It stirs evenly, obtains colloidal sol 3；
(d)：Colloidal sol 3 is cooled to 44~46 DEG C, is sequentially addedA91, fragrant fresh ketone, yeast tunning carry
It is cooled to 29~32 DEG C after taking object, glycosylglycerol and PBS buffer solution to stir evenly, obtains precursor sol.
A kind of above-mentioned maintenance gel provided by the invention is being prepared for alleviating dry skin, aging, dark yellow, color spot, acne
Application in acne and allergic symptom cosmetics.
Compared with prior art, beneficial effects of the present invention are：
Maintenance gel provided by the invention, the maintenance gel include basic fibroblast growth factor bFGF and precursor
Colloidal sol；The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：1000000.Above-mentioned bFGF
Preferable stability can be kept in body colloidal sol before this invention, is still had in normal temperature state storage half a year after testing preferable
Vigor, the problem of existing skin-protection product of ingredient containing bFGF bad preservation at normal temperatures has been effectively relieved, and then effectively reduce bFGF
In the price of skin care application field.Simultaneously the glycosylglycerol in precursor sol, PEG/PPG-14/7 dimethyl ethers,The components such as A91, fragrant fresh ketone and yeast tunning extract have good moisturizing, whitening, it is anti-oxidant with
And antiallergy and other effects, it is not only able to the use of each component respectively play original effect with bFGF, while energy between each component
Synergistic effect is enough played, its curative effect is further strengthened, for symptoms such as dry skin, aging, dark yellow, color spot, small pox and allergy
Alleviation be substantially better than existing skin care item.
The preparation method of maintenance gel provided by the invention is molten to use the method that substep cooling feeds to prepare precursor first
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when colloidal sol step cooling is to 29~32 DEG C
Maintenance gel.The above method basic fibroblast growth factor bFGF is added in 29~32 DEG C of colloidal sol, can effectively keep away
The problem of exempting from the albuminous degeneration of bFGF caused by high temperature, while bFGF is added at a certain temperature so that bFGF is more uniformly distributed
Adequately it is scattered among maintenance gel.
Maintenance gel provided by the invention, which can be widely applied to prepare, alleviates dry skin, aging, dark yellow, color spot, acne
In the cosmetics of acne and allergic symptom.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality
It is a part of the embodiment of the present invention to apply example, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
The every other embodiment that art personnel are obtained without making creative work belongs to the model that the present invention protects
It encloses.
According to an aspect of the present invention, a kind of maintenance gel, the maintenance gel includes basic fibroblast growth
Factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：60~100 parts of deionized water, glycerine 1~
10 parts, 1~10 part of mannitol, 0.2~2 part of PEG/PPG-14/7 dimethyl ethers, 0.5~5 part of D-pantothenyl aleohol, glycosylglycerol 0.3
~5 parts, 0.2~0.6 part of carbomer, 0.2~0.6 part of triethanolamine,0.3~0.7 part of A91, fragrant fresh ketone 0.15
~0.5 part, 0.05~0.3 part of yeast tunning extract, 0.01~0.3 part of Sodium Hyaluronate, EDETATE SODIUM 0.01~0.1
0.5~10 part of part and PBS buffer solution；
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：1000000.
Maintenance gel provided by the invention, the maintenance gel include basic fibroblast growth factor bFGF and precursor
Colloidal sol；The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：1000000.Above-mentioned bFGF
Preferable stability can be kept in body colloidal sol before this invention, is still had in normal temperature state storage half a year after testing preferable
Vigor, the problem of existing skin-protection product of ingredient containing bFGF bad preservation at normal temperatures has been effectively relieved, and then effectively reduce bFGF
In the price and application range of skin care application field.Glycosylglycerol in precursor sol, PEG/PPG-14/7 dimethyl simultaneously
Ether,The components such as A91, fragrant fresh ketone and yeast tunning extract have good moisturizing, whitening, anti-oxidant
And antiallergy and other effects, it is not only able to respectively play original effect with the use of each component with bFGF, while between each component
Synergistic effect can be played, its curative effect is further strengthened, for diseases such as dry skin, aging, dark yellow, color spot, small pox and allergy
The alleviation of shape is substantially better than existing skin care item.
Precursor sol of the present invention is mainly by deionized water, glycerine, mannitol, PEG/PPG-14/7 dimethyl ethers, D-
Panthenol, glycosylglycerol, carbomer, triethanolamine,It is A91, fragrant fresh ketone, yeast tunning extract, transparent
Matter acid sodium, EDETATE SODIUM and PBS buffer solution composition, wherein：
PEG/PPG-14/7 dimethyl ethers：It is a kind of parents' ingredient, water can be got close to and get close to oil, using in skin
When surface, one layer of leatheret adipose membrane can be formed well, that is to say, that can be maintained a good moistening effect.Before the present invention
In body colloidal sol, the typical but non-limiting content of PEG/PPG-14/7 dimethyl ethers is：0.2 part, 0.5 part, 0.8 part, 1
Part, 1.2 parts, 1.5 parts, 1.8 parts and 2 parts.
D-pantothenyl aleohol：D-pantothenyl aleohol is the precursor of vitamin B5, therefore also known as dexpanthenol, and the nursing role on skin is shown as
The moisturizer penetrated deep into stimulates the growth of epithelial cell, promotes wound healing, plays antiinflammation.In precursor sol of the present invention,
The typical but non-limiting content of D-pantothenyl aleohol is：0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5
Part and 5 parts.
Glycosylglycerol：It is a kind of substance combined with glycosidic bond with glucose molecule by glycerine, with moisturizing, anti-oxidant
Function.In precursor sol of the present invention, the typical but non-limiting content of glycosylglycerol is：0.3 part, 1 part, 2 parts, 3 parts,
4 parts and 5 parts.
Triethanolamine：Triethanolamine is the most frequently used neutralizer containing the acid high-molecular gel such as carbomer, triethanolamine
By being neutralized with carboxyls such as carbomers, stable macromolecular structure is formed, the application effect of thickening and moisturizing is reached.Before the present invention
In body colloidal sol, the typical but non-limiting content of triethanolamine is：0.2 part, 0.3 part, 0.4 part, 0.5 part and 0.6 part.
A91：The present inventionA91 is one kind of the Guangzhou bio tech ltd Ai Zhuo production
Bacteriostatic agent, main active are glycerol caprylate and decoyl hydroximic acid, and broad-spectrum antiseptic has preferable suppression to bacterium, fungi
Effect processed.It is described in precursor sol of the present inventionThe typical but non-limiting contents of A91 are：0.3 part, 0.4 part,
0.5 part, 0.6 part and 0.7 part.
Fragrant fresh ketone：It is applied in the application maintenance gel as a kind of Preservative Technology for Personal Care.In precursor sol of the present invention,
The fragrant fresh typical but non-limiting content of ketone is：0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part and 0.5
Part.
Yeast tunning extract：It is applied in the application maintenance gel as a kind of bacteriostatic agent.Precursor of the present invention is molten
In glue, the typical but non-limiting content of yeast tunning extract is：0.05 part, 0.1 part, 0.15 part, 0.2 part,
0.25 part and 0.3 part.
Sodium Hyaluronate：Sodium Hyaluronate is a kind of intrinsic ingredient in human body, is a kind of glucan aldehydic acid, without kind
Specificity.Traditional theory thinks that the formation of wrinkle is related with the fracture of collagen elastic fibers or loss.Modern medicine study is sent out
Existing, another basic reason that wrinkle is formed is the change of cytoplasm, i.e., the aeriform part " hyaluronic acid " between cell
It reduces, and it is exactly by supplementing the invisible interstitial components lost, in turn that cytoskeleton and elastic fibers, which still have the miniature lift faces of,
The metabolism environment and moisture and ionic equilibrium of change cell, to increase the viscoplasticity of skin.Therefore, Sodium Hyaluronate application
And have the effect of good crease-resistant moisturizing in maintenance gel of the present invention.In precursor sol of the present invention, the Sodium Hyaluronate allusion quotation
Type but unrestricted content is：0.01 part, 0.05 part, 0.1 part, 0.15 part, 0.2 part, 0.25 part and 0.3 part.
EDETATE SODIUM：It can soften the quality of gel in maintenance gel of the present invention as a kind of complexing agent, while make to coagulate
Glue keeps chromatic colour.In precursor sol of the present invention, the typical but non-limiting content of EDETATE SODIUM is：0.01 part,
0.02 part, 0.04 part, 0.06 part, 0.08 part and 0.1 part.
Deionized water, glycerine, mannitol, carbomer and PBS buffer solution are applied to the present invention as the auxiliary material for preparing gel
In maintenance gel.In precursor sol of the present invention, the typical but non-limiting content of deionized water is：60 parts, 70 parts, 80
Part, 90 parts and 100 parts；The typical but non-limiting content of glycerine is：0.3 part, 1 part, 2 parts, 3 parts, 4 parts and 5 parts；It is described
The typical but non-limiting content of mannitol is：1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts；The card
The typical but non-limiting content of wave nurse is：0.2 part, 0.3 part, 0.4 part, 0.5 part and 0.6 part；The PBS buffer solution it is typical but
Unrestricted content is：0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts.
In the preferred embodiment of the present invention, the precursor sol is counted in parts by weight, mainly by the following raw material
It is made：70~90 parts of deionized water, 3~7 parts of glycerine, 3~7 parts of mannitol, 0.5~1.5 part of PEG/PPG-14/7 dimethyl ethers,
2~4 parts of D-pantothenyl aleohol, 2~4 parts of glycosylglycerol, 0.2~0.5 part of carbomer, 0.2~0.5 part of triethanolamine,
0.3~0.6 part of A91,0.2~0.4 part of fragrant fresh ketone, 0.1~0.3 part of yeast tunning extract, Sodium Hyaluronate 0.1~
1~8 part of 0.3 part, 0.02~0.08 part of EDETATE SODIUM and PBS buffer solution.
In above-mentioned preferred embodiment, the precursor sol is counted in parts by weight, is mainly made of the following raw material：Go from
75~85 parts of sub- water, 4~6 parts of glycerine, 4~6 parts of mannitol, 0.8~1.2 part of PEG/PPG-14/7 dimethyl ethers, D-pantothenyl aleohol 2.5
~3.5 parts, 2.5~3.5 parts of glycosylglycerol, 0.3~0.4 part of carbomer, 0.3~0.4 part of triethanolamine,
0.4~0.6 part of A91,0.25~0.35 part of fragrant fresh ketone, 0.15~0.25 part of yeast tunning extract, Sodium Hyaluronate
4~6 parts of 0.15~0.25 part, 0.04~0.06 part of EDETATE SODIUM and PBS buffer solution；
Preferably, the precursor sol is counted in parts by weight, is mainly made of the following raw material：80 parts of deionized water, glycerine 5
Part, 5 parts of mannitol, 1 part of PEG/PPG-14/7 dimethyl ethers, 3 parts of D-pantothenyl aleohol, 3 parts of glycosylglycerol, 0.4 part of carbomer, three second
0.4 part of hydramine,0.5 part of A91,0.3 part of fragrant fresh ketone, 0.2 part of yeast tunning extract, Sodium Hyaluronate
5 parts of 0.2 part, 0.05 part of EDETATE SODIUM and PBS buffer solution.
In the present invention, by the further adjustment and optimization to each component raw material dosage ratio, to advanced optimize
The technique effect of precursor sol of the present invention.
In the preferred embodiment of the present invention, the yeast tunning extract is TP·
Group Star。
As a preferred embodiment, above-mentioned yeast tunning extract is TP·Group
Star, it is describedTPGroup Star are a kind of bacteriostatic agent of the Guangzhou bio tech ltd Ai Zhuo production,
Main active is yeast tunning extract and pungent glycol, and component is synergistic, and broad-spectrum antiseptic to bacterium, fungi, is put
Line bacterium etc. has strong inhibition.
In the preferred embodiment of the present invention, it is extracted in the never dead grass of the glycosylglycerol and salt tolerant algae
Active material lattice Lay can mattress.
As a preferred embodiment, Ge Lai can mattress be that through living things catalysis process, (enzymatic is anti-by sucrose and glycerine
Answer) made from a kind of natural materials, be the enantiomter of unique glycosylglycerol on the market, be not dead grass and salt tolerant algae is
Survival and reflorescene and the active constituent that generates.Lattice Lay can mattress specifically have following effect：(1) cell membrane and cell knot are protected
Structure invariance is not damaged；(2) there is excellent water lock ability, even if habitat humidity is very low, the water in cell still remains；
(3) n cell activator has potent activation and power of regeneration：Enhance cell viability and metabolism, activating and regenerating skin
The synthesis, mitigation of I-type collagen precursor are ultraviolet in cell, the inoxidizability (SOD) for enhancing Skin Cell, accelerated ageing cell
Line is to skin injury (playing erythema, bubble, decortication), accelerating wound healing and tissue repair.
According to an aspect of the present invention, a kind of preparation method of maintenance gel, the described method comprises the following steps：
Precursor sol is prepared using the method for substep cooling charging first, when colloidal sol step cooling is to 29~32 DEG C, is added
Enter basic fibroblast growth factor bFGF to be sufficiently mixed uniformly, obtains maintenance gel.
The preparation method of maintenance gel provided by the invention is molten to use the method that substep cooling feeds to prepare precursor first
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when colloidal sol step cooling is to 29~32 DEG C
Maintenance gel.The above method basic fibroblast growth factor bFGF is added in 29~32 DEG C of colloidal sol, can effectively keep away
The problem of exempting from the albuminous degeneration of bFGF caused by high temperature, while bFGF is added at a certain temperature so that bFGF is more uniformly distributed
Adequately it is scattered among maintenance gel.
In the preferred embodiment of the present invention, it includes following step that the substep cooling charging, which prepares precursor sol,
Suddenly：
(a)：85~90 DEG C will be heated to after deionized water, EDETATE SODIUM, glycerine, carbomer mixing first, subsequent homogeneous 6
15~20min is kept the temperature after~9min, obtains colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 60~65 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, three ethyl alcohol are added
Amine stirs evenly, and obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 52~54 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, PEG/PPG-14/7 dimethyl ethers
It stirs evenly, obtains colloidal sol 3；
(d)：Colloidal sol 3 is cooled to 44~46 DEG C, is sequentially addedA91, fragrant fresh ketone, yeast tunning carry
It is cooled to 29~32 DEG C after taking object, glycosylglycerol and PBS buffer solution to stir evenly, obtains precursor sol.
As a preferred embodiment, the method that above-mentioned substep cooling charging prepares precursor sol, in different temperature
Corresponding raw material is added under the conditions of degree, avoids temperature to the full extent to the influence of raw material in gel, while also making to coagulate
Each component in glue is dispersed among colloidal sol.
According to an aspect of the present invention, a kind of above-mentioned maintenance gel prepare for alleviate dry skin, aging, secretly
Application in Huang, color spot, small pox and allergic symptom cosmetics.
Maintenance gel provided by the invention, which can be widely applied to prepare, alleviates dry skin, aging, dark yellow, color spot, acne
In the cosmetics of acne and allergic symptom.
Technical scheme of the present invention is described further below in conjunction with embodiment and comparative example.
Embodiment 1
A kind of maintenance gel, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1：1000000.
Embodiment 2
A kind of maintenance gel, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 2：1000000.
Embodiment 3
A kind of shield repairing glue, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1.2：1000000.
Embodiment 4
A kind of maintenance gel, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1.8：1000000.
Embodiment 5
A kind of maintenance gel, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1.5：1000000.
Embodiment 6
A kind of preparation method of maintenance gel, the described method comprises the following steps：
Raw material is weighed by mass fraction described in embodiment 1, it is molten then to prepare precursor using the method for substep cooling charging
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when precursor sol step cooling is to 29 DEG C
Maintenance gel.
The substep cooling charging prepares precursor sol and includes the following steps：
(a)：85~90 DEG C will be heated to after deionized water, EDETATE SODIUM, glycerine, carbomer mixing first, subsequent homogeneous
15min is kept the temperature after 6min, obtains colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 60 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, triethanolamine is added and stirs
It mixes uniformly, obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 52 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, the stirring of PEG/PPG-14/7 dimethyl ethers
Uniformly, colloidal sol 3 is obtained；
(d)：Colloidal sol 3 is cooled to 44 DEG C, is sequentially addedA91, fragrant fresh ketone, the extraction of yeast tunning
Object, glycosylglycerol and PBS buffer solution are cooled to 29 DEG C after stirring evenly, obtain precursor sol.
Embodiment 7
A kind of preparation method of maintenance gel, the described method comprises the following steps：
Raw material is weighed by the mass fraction described in embodiment 2, it is molten then to prepare precursor using the method for substep cooling charging
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when precursor sol step cooling is to 32 DEG C
Maintenance gel.
The substep cooling charging prepares precursor sol and includes the following steps：
(a)：90 DEG C will be heated to after deionized water, EDTA- disodiums, glycerine, carbomer mixing first, subsequent homogeneous 9min
After keep the temperature 20min, obtain colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 65 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, triethanolamine is added and stirs
It mixes uniformly, obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 54 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, the stirring of PEG/PPG-14/7 dimethyl ethers
Uniformly, colloidal sol 3 is obtained；
(d)：Colloidal sol 3 is cooled to 46 DEG C, is sequentially addedA91, fragrant fresh ketone, the extraction of yeast tunning
Object, glycosylglycerol and PBS buffer solution are cooled to 32 DEG C after stirring evenly, obtain precursor sol.Embodiment 8
A kind of preparation method of maintenance gel, the described method comprises the following steps：
Raw material is weighed by mass fraction described in embodiment 3, it is molten then to prepare precursor using the method for substep cooling charging
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when precursor sol step cooling is to 30 DEG C
Maintenance gel.
The substep cooling charging prepares precursor sol and includes the following steps：
(a)：86 DEG C will be heated to after deionized water, EDTA- disodiums, glycerine, carbomer mixing first, subsequent homogeneous 7min
After keep the temperature 18min, obtain colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 61 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, triethanolamine is added and stirs
It mixes uniformly, obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 53 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, the stirring of PEG/PPG-14/7 dimethyl ethers
Uniformly, colloidal sol 3 is obtained；
(d)：Colloidal sol 3 is cooled to 44 DEG C, is sequentially addedA91, fragrant fresh ketone, the extraction of yeast tunning
Object, glycosylglycerol and PBS buffer solution are cooled to 30 DEG C after stirring evenly, obtain precursor sol.
Embodiment 9
A kind of preparation method of maintenance gel, the described method comprises the following steps：
Raw material is weighed by the mass fraction described in embodiment 4, it is molten then to prepare precursor using the method for substep cooling charging
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when precursor sol step cooling is to 31 DEG C
Maintenance gel.
The substep cooling charging prepares precursor sol and includes the following steps：
(a)：89 DEG C will be heated to after deionized water, EDTA- disodiums, glycerine, carbomer mixing first, subsequent homogeneous 8min
After keep the temperature 18min, obtain colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 64 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, triethanolamine is added and stirs
It mixes uniformly, obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 53 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, the stirring of PEG/PPG-14/7 dimethyl ethers
Uniformly, colloidal sol 3 is obtained；
(d)：Colloidal sol 3 is cooled to 45 DEG C, is sequentially addedA91, fragrant fresh ketone, the extraction of yeast tunning
Object, glycosylglycerol and PBS buffer solution are cooled to 31 DEG C after stirring evenly, obtain precursor sol.
Embodiment 10
A kind of preparation method of maintenance gel, the described method comprises the following steps：
Raw material is weighed by the mass fraction described in embodiment 5, it is molten then to prepare precursor using the method for substep cooling charging
Glue is added basic fibroblast growth factor bFGF and is sufficiently mixed uniformly, obtain when precursor sol step cooling is to 30 DEG C
Maintenance gel.
The substep cooling charging prepares precursor sol and includes the following steps：
(a)：86 DEG C will be heated to after deionized water, EDTA- disodiums, glycerine, carbomer mixing first, subsequent homogeneous 7min
After keep the temperature 18min, obtain colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 63 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, triethanolamine is added and stirs
It mixes uniformly, obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 53 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, the stirring of PEG/PPG-14/7 dimethyl ethers
Uniformly, colloidal sol 3 is obtained；
(d)：Colloidal sol 3 is cooled to 45 DEG C, is sequentially addedA91, fragrant fresh ketone, the extraction of yeast tunning
Object, glycosylglycerol and PBS buffer solution are cooled to 30 DEG C after stirring evenly, obtain precursor sol.
Comparative example 1
A kind of maintenance gel, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1.5：1000000.
The preparation method is the same as that of Example 10 for this comparative example maintenance gel.
Comparative example 2
A kind of maintenance gel, the maintenance gel include basic fibroblast growth factor bFGF and precursor sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1.5：1000000.
The preparation method is the same as that of Example 10 for this comparative example maintenance gel.
Experimental example 1bFGF stability experiments
(the required bFGF concentration of an active unit is bigger, illustrates that bFGF activity is lower.)
1, maintenance gel is stored at 4 DEG C, units activity bFGF testing results are as shown in the table within 6 months：
2, (15-25 DEG C) maintenance gel at room temperature is stored, units activity bFGF testing results are as shown in the table within 6 months：
It can be seen from the above, being stored at a temperature of room temperature and 4 DEG C two kinds, bFGF activity declines successively with period of storage；Low temperature
Be conducive to the holding of bFGF activity, storage bFGF loss of activity is very fast under room temperature, but still can meet requirement (national standard
It is not higher than 5ng/ml for unit activity bFGF dosages).And bacteriostatic agent is not included in 1 precursor sol of comparative example A91
WithThe maintenance gel and comparative example 2 of TPGroup Star do not include Ge Lai can mattress maintenance gel normal
After the lower preservation of temperature 6 months, the vigor of bFGF is then less than national standard.
2 maintenance gelling performance of experimental example measures
1, the long-acting moisturizings of 8h
Test crowd：100 people, daily using maintenance gel 1 time, skin moisture tester made from the embodiment of the present invention 10
Measure the water content after skin 8h.Moisture content of skin increases by 24.1% compared with the control group of unused maintenance gel of the present invention.
2, after-sun：Mitigate rubefaction, gets blister, peels
Test crowd：100 people test 5 days, daily using maintenance gel 2 times made from the embodiment of the present invention 10.100%
Tester feeds back sunburn and mitigates, and has 82% tester's after-sun effect good, and rubefaction, the phenomenon that getting blister, peeling are complete
It disappears.
3, senile-resistant efficacy
Test crowd：50 people, 40-50 Sui women tester test 28 days, daily using made from the embodiment of the present invention 10
Maintenance gel 2 times.
Test parameter：Skin elasticity, smoothness, after being used continuously 28 days, the results are shown in table below：
| Skin performance | Compared with the control group of unused maintenance gel |
| Skin elasticity (Cutometer) | Increase by 8.20% |
| Smoothness (skin three-dimensional imaging instrument) | Increase by 26.80% |
4, whitening bright color
Test crowd：100 people, 30-45 Sui women tester test 28 days, are made daily using the embodiment of the present invention 10
Maintenance gel 2 times.After continuous use 28 days, 83% tester feedback is effective, the no effect of 17% tester feedback, and 46%
Tester's feedback effects are good.
5, promote wound healing, desalination scar
Test crowd：100 people, 16-28 Sui tester's (small pox skin) test 35 days, use the embodiment of the present invention daily
Maintenance gel 2 times made from 10.86% tester's feedback effects are good, and wound heals substantially, and scar has substantially reduced sign.
In conclusion maintenance gel provided by the invention, the maintenance gel includes basic fibroblast growth factor
BFGF and precursor sol；The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：
1000000.Above-mentioned bFGF can keep preferable stability in body colloidal sol before this invention, after testing in normal temperature state storage half
Still there is in year preferable vigor, the problem of existing skin-protection product of ingredient containing bFGF bad preservation at normal temperatures has been effectively relieved,
And then effectively reduce bFGF skin care application field price and application range.Simultaneously the glycosylglycerol in precursor sol,
PEG/PPG-14/7 dimethyl ethers,The components such as A91, fragrant fresh ketone and yeast tunning extract have fine
Moisturizing, whitening, anti-oxidant and antiallergy and other effects are not only able to respectively play original work(with bFGF with the use of each component
Effect, while can play synergistic effect between each component, further strengthen its curative effect, for dry skin, aging, dark yellow, color spot,
The alleviation of the symptoms such as small pox and allergy is substantially better than existing skin care item.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (8)
1. a kind of maintenance gel, which is characterized in that the maintenance gel includes basic fibroblast growth factor bFGF with before
Body colloidal sol；
The precursor sol is counted in parts by weight, is mainly made of the following raw material：60~100 parts of deionized water, glycerine 1~10
Part, 1~10 part of mannitol, 0.5~5 part of D-pantothenyl aleohol, 0.3~5 part of glycosylglycerol, PEG/PPG-14/7 dimethyl ethers 0.2~2
Part, 0.2~0.6 part of carbomer, 0.2~0.6 part of triethanolamine,0.3~0.7 part of A91, fragrant fresh ketone 0.15~
0.5 part, 0.05~0.3 part of yeast tunning extract, 0.01~0.3 part of Sodium Hyaluronate, 0.01~0.1 part of EDETATE SODIUM
With 0.5~10 part of PBS buffer solution；
The mass ratio of the basic fibroblast growth factor bFGF and precursor sol is 1~2：1000000.
2. maintenance gel according to claim 1, which is characterized in that the precursor sol is counted in parts by weight, mainly by
The following raw material is made：70~90 parts of deionized water, 3~7 parts of glycerine, 3~7 parts of mannitol, 2~4 parts of D-pantothenyl aleohol, glycosylglycerol
2~4 parts, 0.5~1.5 part of PEG/PPG-14/7 dimethyl ethers, 0.2~0.5 part of carbomer, 0.2~0.5 part of triethanolamine,0.3~0.6 part of A91,0.2~0.4 part of fragrant fresh ketone, 0.1~0.3 part of yeast tunning extract, hyalomitome
1~8 part of 0.1~0.3 part of sour sodium, 0.02~0.08 part of EDETATE SODIUM and PBS buffer solution.
3. maintenance gel according to claim 1, which is characterized in that the precursor sol is counted in parts by weight, mainly by
The following raw material is made：75~85 parts of deionized water, 4~6 parts of glycerine, 4~6 parts of mannitol, PEG/PPG-14/7 dimethyl ethers 0.8
~1.2 parts, 2.5~3.5 parts of D-pantothenyl aleohol, 2.5~3.5 parts of glycosylglycerol, 0.3~0.4 part of carbomer, triethanolamine 0.3~
0.4 part,0.4~0.6 part of A91,0.25~0.35 part of fragrant fresh ketone, yeast tunning extract 0.15~
4~6 parts of 0.25 part, 0.15~0.25 part of Sodium Hyaluronate, 0.04~0.06 part of EDETATE SODIUM and PBS buffer solution；
Preferably, the precursor sol is counted in parts by weight, is mainly made of the following raw material：80 parts of deionized water, 5 parts of glycerine,
5 parts of mannitol, 1 part of PEG/PPG-14/7 dimethyl ethers, 3 parts of D-pantothenyl aleohol, 3 parts of glycosylglycerol, 0.4 part of carbomer, three ethyl alcohol
0.4 part of amine,0.5 part of A91,0.3 part of fragrant fresh ketone, 0.2 part of yeast tunning extract, Sodium Hyaluronate 0.2
5 parts of part, 0.05 part of EDETATE SODIUM and PBS buffer solution.
4. according to claims 1 to 3 any one of them maintenance gel, which is characterized in that the yeast tunning extract
For TP·Group Star。
5. according to claims 1 to 3 any one of them maintenance gel, which is characterized in that the glycosylglycerol is never dead
The active material lattice Lay extracted in grass and salt tolerant algae can mattress.
6. a kind of preparation method according to Claims 1 to 5 any one of them maintenance gel, which is characterized in that the method
Include the following steps：
Precursor sol is prepared using the method for substep cooling charging first, when precursor sol step cooling is to 29~32 DEG C, is added
Enter basic fibroblast growth factor bFGF to be sufficiently mixed uniformly, obtains maintenance gel.
7. the preparation method of maintenance gel according to claim 6, which is characterized in that before prepared by the substep cooling charging
Body colloidal sol includes the following steps：
(a)：It will be heated to 85~90 DEG C after deionized water, EDETATE SODIUM, glycerine, carbomer mixing first, subsequent homogeneous 6~
15~20min is kept the temperature after 9min, obtains colloidal sol 1；
(b)：Colloidal sol 1 is cooled to 60~65 DEG C, Sodium Hyaluronate is then added, after stirring and dissolving is complete, triethanolamine is added and stirs
It mixes uniformly, obtains colloidal sol 2；
(c)：Colloidal sol 2 is cooled to 52~54 DEG C, sequentially adds mannitol, D-pantothenyl aleohol, the stirring of PEG/PPG-14/7 dimethyl ethers
Uniformly, colloidal sol 3 is obtained；
(d)：Colloidal sol 3 is cooled to 44~46 DEG C, is sequentially addedA91, fragrant fresh ketone, yeast tunning extract,
Glycosylglycerol and PBS buffer solution are cooled to 29~32 DEG C after stirring evenly, obtain precursor sol.
8. it is a kind of according to Claims 1 to 5 any one of them maintenance gel prepare for alleviate dry skin, aging, secretly
Application in Huang, color spot, small pox and allergic symptom cosmetics.
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Cited By (1)
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| CN111317675A (en) * | 2019-12-27 | 2020-06-23 | 南京泛成生物科技有限公司 | Acne removing composition containing D-panthenol, application of acne removing composition and cosmetics containing composition |
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