CN114288221A - A method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect and its application - Google Patents
A method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect and its application Download PDFInfo
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Abstract
The invention discloses a preparation method of essence containing polypeptide and plant extract and having a hair growth effect, which is characterized by comprising the following raw materials in parts by weight: 0.1-1 part of tripeptide-1, 0.01-0.0.5 parts of tripeptide-1 copper, 1-6 parts of acetyl tetrapeptide-3, 0.5-3 parts of octapeptide-2, 1-8 parts of nutmeg pentapeptide-17, 0.1-3 parts of oligopeptide-1, 0.1-3 parts of oligopeptide-3, 1-4 parts of oligopeptide-5, 0.01-0.1 part of soluble collagen peptide, 50-80 parts of traditional Chinese medicine extracting solution and 3-12 parts of deionized water. The essence disclosed by the invention can accelerate blood circulation of scalp capillaries, promote hair follicle regeneration, stimulate cell activity, and promote hair growth due to the nutrition effect of active polypeptide.
Description
Technical Field
The invention relates to the technical field of production of daily chemical products, and particularly relates to a preparation method and application of essence containing polypeptide and plant extract with a hair growth effect.
Background
When the hair lacks necessary active protein (hair cell growth protein), the hair gradually shrinks after each renewal and replacement, gradually becomes coarse, becomes short, becomes young and thin, and shrinks until white hair which is difficult to see by naked eyes, and then the daily baldness symptom is formed. Alopecia has many causes, such as alopecia caused by exogenous bacterial infection and secondary inflammatory infiltration to damage hair follicle stem cells, alopecia caused by nutrient deficiency of hair roots due to scalp microfilament blood vessel inactivity, hair growth cycle shortening due to abnormal secretion of dihydrotestosterone in organisms, hair loss caused by hair follicle microminiaturization and even atrophy, scalp damage caused by permanent dyeing, familial genetic causes, in vivo immunity reduction, and the like. The most common types of hair loss are seborrheic and neurotic. In the prior art, the preparation for treating alopecia mainly comprises western medicines, Chinese herbal medicine effective substances or active polypeptide products.
The polypeptide substance and the Chinese herbal medicine composition have the functions of preventing hair loss and strengthening hair, but have the advantages and disadvantages. The Chinese herbal medicine composition has simple process and low preparation cost, has auxiliary synergistic effect, but has poor alopecia prevention effect and slow effect; the polypeptide substance is difficult to synthesize, has high requirement on storage condition and high manufacturing cost, often only has the effect of preventing alopecia without auxiliary synergistic effect, and although the active polypeptide product has specific target spots and quick response, the active polypeptide substance does not have the multidirectional auxiliary synergistic effect of the traditional Chinese medicine extract. Therefore, there is a high necessity for an essence solution that can solve the above problems.
Disclosure of Invention
The invention aims to: aiming at the problems mentioned in the background technology, the essence prepared by the invention can accelerate the blood circulation of scalp capillary, promote the hair follicle regeneration, stimulate the cell activity, has the nutrition effect of active polypeptide and promote the hair growth, and the preparation method is easy to operate and convenient for batch production.
In order to achieve the purpose of the invention, the technical scheme adopted by the invention is as follows:
a preparation method of essence containing polypeptide and plant extract with hair growth promoting effect comprises the following raw materials by weight: 0.1-1 part of tripeptide-1, 0.01-0.0.5 parts of tripeptide-1 copper, 1-6 parts of acetyl tetrapeptide-3, 0.5-3 parts of octapeptide-2, 1-8 parts of nutmeg pentapeptide-17, 0.1-3 parts of oligopeptide-1, 0.1-3 parts of oligopeptide-3, 1-4 parts of oligopeptide-5, 0.01-0.1 part of soluble collagen peptide, 50-80 parts of traditional Chinese medicine extracting solution and 3-12 parts of deionized water.
Further, the traditional Chinese medicine extracting solution is a mixed extracting solution of cacumen biotae, angelica and pseudo-ginseng.
Further, the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) pretreatment: cleaning folium Platycladi, radix Angelicae sinensis, and Notoginseng radix, sun drying respectively, pulverizing, sieving, adding corresponding enzymolysis liquid, performing enzymolysis at certain temperature, performing microwave treatment to obtain pretreated powder, mixing, and placing in supercritical extraction device;
(2) supercritical extraction: adding a stabilizing agent and an extracting agent into a supercritical extraction device, mixing with the pretreated powder, and performing carbon dioxide supercritical extraction in the supercritical extraction device to obtain an extraction product;
(3) centrifuging to remove impurities: and (3) carrying out centrifugal separation on the extraction product, removing impurities, putting the extraction product in a rotary evaporator to evaporate the extractant, and adding deionized water to dilute the extraction product to obtain the traditional Chinese medicine extracting solution.
Further, the enzymolysis liquid is a mixture of cellulase and pectinase in a mass ratio of 5:3, and the enzymolysis temperature is 40-60 ℃.
Further, the stabilizing agent is catechin, and the extracting agent is ethanol.
Further, the dilution is 5-15 times of the original extract.
Further, the preparation method of the essence comprises the following steps: sequentially adding soluble collagen peptide, tripeptide-1 copper, acetyl tetrapeptide-3, nutmeg pentapeptide-17, octapeptide-2, oligopeptide-1, oligopeptide-3 and oligopeptide-5 into deionized water, adding one of the components, completely dispersing, adding the next component, finally adding the traditional Chinese medicine extracting solution, and uniformly mixing to obtain the essence.
Further, wool acid can be added into the traditional Chinese medicine extracting solution before the traditional Chinese medicine extracting solution is added and mixed, and then the mixed solution is added after mixing and emulsification to obtain the essence.
Tripeptide-1, also known as a dermal growth factor, acts primarily on the dermal layer of the skin, promotes the synthesis of extracellular matrix, such as collagen and glycosaminoglycans, strengthens the dermal layer, makes the skin thicker, firmer, and eases wrinkles.
Tripeptide-1 copper promotes collagen synthesis, tightens loose skin, improves elasticity, and reduces and lightens fine wrinkles; resisting skin oxidation, promoting blood circulation, and relieving inflammation.
Acetyl tetrapeptide-3 with better anti-wrinkle ability. Zwitterionic surfactants-amino acid type; has excellent dispersing and emulsifying capacity. Has low irritation to skin and eyes.
Myristoyl pentapeptide-17 is a potent eyelash growth promoting pentapeptide which directly activates the keratin gene, causing eyelashes to grow and become dense
Octapeptide-2, which enhances hair and stimulates hair follicles to produce healthy hair, and myristoyl pentapeptide-17, which prevents hair from whitening, is an effective eyelash growth promoting pentapeptide, which can directly activate keratin gene, thereby growing eyelashes and thickening the eyelashes
Oligopeptide-1 can promote the growth of injured skin tissue, inhibit gastric acid secretion, and promote the growth of burn skin and the healing of skin ulcer. Has good repairing and nursing effects on damaged skin, sensitive skin and wounded skin. Promoting synthesis of collagen and collagenase, secreting collagen substances, hyaluronic acid and glycoprotein, moistening skin, improving skin elasticity, reducing skin wrinkles and preventing skin aging. Lightening the pigmentation of the skin, thus achieving the aims of whitening and removing freckles. Repairing damaged cells, relieving damage of direct ultraviolet rays to skin, reducing growth of black spots on the skin after sunburn, eliminating gene mutation factors of the damaged cells, and preventing photoaging.
Oligopeptide-3, oligopeptide-3 can promote the growth and reproduction of skin tissue, and it can regulate and control the division, reproduction and growth and differentiation of skin epithelial, endothelial and stromal cells, promote cell metabolism and enhance oxidation by combining with cell surface specific receptor. The peptide has small molecular weight and short amino acid chain, and is easy to be absorbed and utilized by human body. The main biological effects are as follows: as a vascular growth factor; promoting wound healing and tissue repair; promoting tissue regeneration; involved in nerve regeneration, etc. In the field of cosmetics, oligopeptide-3 can promote proliferation and differentiation of fibroblasts, has a deep repair effect, and can be used for repairing newly-generated pocks, spots, nevi and acnes after laser and red blood streak; improving the internal environment of cell growth, promoting the synthesis of elastic fiber and collagen, regulating skin texture, reducing ruddy and glossy skin color, and making skin soft, smooth and elastic.
Oligopeptide-5, specifically stimulate the metabolism of epithelial cells, repair cuticle, increase the thickness of the cuticle, enhance the activity of collagen and elastin, and promote wound healing.
The soluble collagen peptide can effectively supplement collagen of skin, delay skin aging, recover and maintain skin moisture and elasticity, and promote skin smoothness and tenderness. The contained 'human-like collagen active stock solution' can rapidly repair and promote cell regeneration, block aging, and supplement 30 times of water (tremella, peach gum and coral grass) instantly and powerfully.
The Chinese arborvitae twig has the functions of cooling blood and stopping bleeding, growing hair and blackening hair, eliminating dampness and leucorrhea, relieving cough and eliminating phlegm. It is often used to treat various bleeding syndromes caused by recklessly blood flow due to blood heat; it can also be used for treating premature gray hair and alopecia caused by blood heat.
The angelica has the effects of promoting hair growth and nourishing hair, has high nutrient content, can promote blood circulation and enrich blood, and can improve the hair loss and dark yellow color caused by deficiency of qi and blood.
Notoginseng radix is beneficial for regulating blood circulation and sugar metabolism.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. the essence prepared by the invention contains micromolecular polypeptide, the peptide is micromolecular amino acid, the skin absorption is facilitated, meanwhile, the peptide substance can improve and enhance the cell activity and has the effect of repairing hair follicles, and the hair growth environment can be repaired and improved by matching with the traditional Chinese medicine extracting solution.
2. The essence prepared by the invention contains traditional Chinese medicine extracting solution which has the functions of promoting blood circulation, enriching blood, improving blood circulation and promoting hair growth;
3. the traditional Chinese medicine extracting solution is prepared by adopting carbon dioxide supercritical extraction, so that the extract with small molecular weight can be fully extracted, the absorption is facilitated, and the extraction is easy;
4. the microwave treatment can increase the movement speed of substances in cells in the traditional Chinese medicinal materials and is beneficial to accelerating the extraction rate;
5. when the essence is prepared, the raw materials are sequentially added according to the dissolving performance from large to small, so that the raw materials are fully dissolved.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below with reference to preferred embodiments. It should be noted, however, that the numerous details set forth in the description are merely for the purpose of providing the reader with a thorough understanding of one or more aspects of the present invention, which may be practiced without these specific details.
Example 1
A preparation method of essence containing polypeptide and plant extract with hair growth promoting effect comprises the following raw materials by weight: 0.1 part of tripeptide-1, 0.01 part of tripeptide-1 copper, 1 part of acetyl tetrapeptide-3, 0.5 part of octapeptide-2, 1 part of nutmeg pentapeptide-17, 0.1 part of oligopeptide-1, 0.1 part of oligopeptide-3, 1 part of oligopeptide-5, 0.01 part of soluble collagen peptide, 50 parts of traditional Chinese medicine extracting solution and 3 parts of deionized water.
The preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) pretreatment: cleaning cacumen biotae, angelica sinensis and pseudo-ginseng, drying in the sun respectively, crushing and sieving, adding corresponding enzymolysis liquid respectively, performing enzymolysis at a certain temperature, performing microwave treatment respectively to obtain pretreated powder, mixing the pretreated powder and the pretreated powder in a supercritical extraction device for later use, wherein the enzymolysis liquid is a mixture of cellulase and pectinase in a mass ratio of 5:3, and the enzymolysis temperature is 40 ℃;
(2) supercritical extraction: adding a stabilizing agent and an extracting agent into a supercritical extraction device, mixing the stabilizing agent which is catechin and the extracting agent which is ethanol with the pretreated powder, and performing carbon dioxide supercritical extraction in the supercritical extraction device to obtain an extraction product;
(3) centrifuging to remove impurities: and (3) carrying out centrifugal separation on the extraction product, removing impurities, putting the extraction product in a rotary evaporator to evaporate the extractant, and adding deionized water to dilute the extraction product to 5 times of the original extract to obtain the traditional Chinese medicine extracting solution.
The preparation method of the essence comprises the following steps: sequentially adding soluble collagen peptide, tripeptide-1 copper, acetyl tetrapeptide-3, nutmeg pentapeptide-17, octapeptide-2, oligopeptide-1, oligopeptide-3 and oligopeptide-5 into deionized water, adding one of the components, completely dispersing, adding the next component, finally adding the traditional Chinese medicine extracting solution, and uniformly mixing to obtain the essence.
Example 2
A preparation method of essence containing polypeptide and plant extract with hair growth promoting effect comprises the following raw materials by weight: 1 part of tripeptide-1, 0.0.5 parts of tripeptide-1 copper, 6 parts of acetyl tetrapeptide-3, 3 parts of octapeptide-2, 8 parts of nutmeg pentapeptide-17, 3 parts of oligopeptide-1, 3 parts of oligopeptide-3, 4 parts of oligopeptide-5, 0.01-0.1 soluble collagen peptide, 80 parts of traditional Chinese medicine extracting solution and 12 parts of deionized water.
The preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) pretreatment: cleaning cacumen biotae, angelica sinensis and pseudo-ginseng, drying in the sun respectively, crushing and sieving, adding corresponding enzymolysis liquid respectively, performing enzymolysis at a certain temperature, performing microwave treatment respectively to obtain pretreated powder, mixing the pretreated powder and the pretreated powder in a supercritical extraction device for later use, wherein the enzymolysis liquid is a mixture of cellulase and pectinase in a mass ratio of 5:3, and the enzymolysis temperature is 60 ℃;
(2) supercritical extraction: adding a stabilizing agent and an extracting agent into a supercritical extraction device, mixing the stabilizing agent which is catechin and the extracting agent which is ethanol with the pretreated powder, and performing carbon dioxide supercritical extraction in the supercritical extraction device to obtain an extraction product;
(3) centrifuging to remove impurities: centrifuging the extract, removing impurities, evaporating the extractant in a rotary evaporator, and diluting with deionized water to 5-15 times of the original extract to obtain Chinese medicinal extractive solution.
The preparation method of the essence comprises the following steps: sequentially adding soluble collagen peptide, tripeptide-1 copper, acetyl tetrapeptide-3, nutmeg pentapeptide-17, octapeptide-2, oligopeptide-1, oligopeptide-3 and oligopeptide-5 into deionized water, adding one of the components, completely dispersing, adding the next component, adding wool acid into the traditional Chinese medicine extract, mixing and emulsifying, and finally adding the traditional Chinese medicine extract and mixing uniformly.
Example 3
A preparation method of essence containing polypeptide and plant extract with hair growth promoting effect comprises the following raw materials by weight: 0.5 part of tripeptide-1, 0.02 part of tripeptide-1 copper, 2 parts of acetyl tetrapeptide-3, 1 part of octapeptide-2, 3 parts of nutmeg pentapeptide-17, 1 part of oligopeptide-1, 1 part of oligopeptide-3, 2 parts of oligopeptide-5, 0.05 soluble collagen peptide, 60 parts of traditional Chinese medicine extracting solution and 5 parts of deionized water.
The preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) pretreatment: cleaning cacumen biotae, angelica sinensis and pseudo-ginseng, drying in the sun respectively, crushing and sieving, adding corresponding enzymolysis liquid respectively, performing enzymolysis at a certain temperature, performing microwave treatment respectively to obtain pretreated powder, mixing the pretreated powder and the pretreated powder in a supercritical extraction device for later use, wherein the enzymolysis liquid is a mixture of cellulase and pectinase in a mass ratio of 5:3, and the enzymolysis temperature is 50 ℃;
(2) supercritical extraction: adding a stabilizing agent and an extracting agent into a supercritical extraction device, mixing the stabilizing agent which is catechin and the extracting agent which is ethanol with the pretreated powder, and performing carbon dioxide supercritical extraction in the supercritical extraction device to obtain an extraction product;
(3) centrifuging to remove impurities: and (3) carrying out centrifugal separation on the extraction product, removing impurities, putting the extraction product in a rotary evaporator to evaporate the extractant, and adding deionized water to dilute the extraction product to 10 times of the original extract to obtain the traditional Chinese medicine extracting solution.
The preparation method of the essence comprises the following steps: sequentially adding soluble collagen peptide, tripeptide-1 copper, acetyl tetrapeptide-3, nutmeg pentapeptide-17, octapeptide-2, oligopeptide-1, oligopeptide-3 and oligopeptide-5 into deionized water, adding one of the components, completely dispersing, adding the next component, finally adding the traditional Chinese medicine extracting solution, and uniformly mixing to obtain the essence.
Example 4
A preparation method of essence containing polypeptide and plant extract with hair growth promoting effect comprises the following raw materials by weight: 0.8 part of tripeptide-1, 0.03 part of tripeptide-1 copper, 5 parts of acetyl tetrapeptide-3, 2 parts of octapeptide-2, 6 parts of nutmeg pentapeptide-17, 2 parts of oligopeptide-1, 2 parts of oligopeptide-3, 3 parts of oligopeptide-5, 0.08 part of soluble collagen peptide, 70 parts of traditional Chinese medicine extracting solution and 10 parts of deionized water.
The preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) pretreatment: cleaning cacumen biotae, angelica sinensis and pseudo-ginseng, drying in the sun respectively, crushing and sieving, adding corresponding enzymolysis liquid respectively, performing enzymolysis at a certain temperature, performing microwave treatment respectively to obtain pretreated powder, mixing the pretreated powder and the pretreated powder in a supercritical extraction device for later use, wherein the enzymolysis liquid is a mixture of cellulase and pectinase in a mass ratio of 5:3, and the enzymolysis temperature is 55 ℃;
(2) supercritical extraction: adding a stabilizing agent and an extracting agent into a supercritical extraction device, mixing the stabilizing agent which is catechin and the extracting agent which is ethanol with the pretreated powder, and performing carbon dioxide supercritical extraction in the supercritical extraction device to obtain an extraction product;
(3) centrifuging to remove impurities: and (3) carrying out centrifugal separation on the extraction product, removing impurities, putting the extraction product in a rotary evaporator to evaporate the extractant, and adding deionized water to dilute the extraction product to 12 times of the original extract to obtain the traditional Chinese medicine extracting solution.
The preparation method of the essence comprises the following steps: sequentially adding soluble collagen peptide, tripeptide-1 copper, acetyl tetrapeptide-3, nutmeg pentapeptide-17, octapeptide-2, oligopeptide-1, oligopeptide-3 and oligopeptide-5 into deionized water, adding one component, completely dispersing, adding the next component, adding wool acid into the traditional Chinese medicine extracting solution, mixing and emulsifying, finally adding the traditional Chinese medicine extracting solution, and uniformly mixing to obtain the essence.
Evaluation of Hair growth Effect
200 volunteers with hair loss time of 1-3 years are searched, male and female proportion is 1:1, the volunteers are all 30-50 years old, and are randomly divided into 5 groups of 40 persons, wherein the volunteers in 1-4 groups use the essence prepared in the examples 1-4 respectively, the 5 th group uses the commercially available hair loss prevention and hair growth promotion liquid, and the product which is well sold in the market is selected as a control group.
The test method comprises the following steps: after washing the hair, pressing the hair with a dry towel, drying to seven dry, respectively applying the essence prepared in examples 1-4 and the commercially available anti-hair loss and hair growth promoting liquid to the hair of each group, massaging for 5 minutes until the hair is absorbed, and continuously using for 90 days; wherein the composition is used continuously on day 1-7, and is used every 3 days.
The curative effect standard is as follows:
(1) the effect is shown: no obvious alopecia, a large amount of new hair, fresh and cool hair without greasiness, and no pruritus of scalp.
(2) The method has the following advantages: alopecia is controlled, little new hair is generated, and the degree of greasiness of hair and the degree of scalp itching are improved.
(3) And (4) invalidation: there was no change before and after treatment.
The results are shown in Table 1.
| Group of | Show effect/human | Effective/human | Invalid/human | Total effective rate/%) |
| Example 1 | 30 | 7 | 3 | 92.5 |
| Example 2 | 29 | 7 | 4 | 90 |
| Example 3 | 27 | 8 | 5 | 87.5 |
| Example 4 | 30 | 7 | 3 | 92.5 |
| Control group | 22 | 8 | 10 | 75 |
As can be seen from table 1, the effective rates of the essence of the present invention in promoting hair follicle growth of scalp, improving hair loss and promoting hair growth are all higher than those of the control group. The essence of the invention has better effects of preventing hair loss and growing hair.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be construed as the protection scope of the present invention.
Claims (8)
1. A preparation method of essence containing polypeptide and plant extract with hair growth promoting effect is characterized by comprising the following raw materials in parts by weight: 0.1-1 part of tripeptide-1, 0.01-0.0.5 parts of tripeptide-1 copper, 1-6 parts of acetyl tetrapeptide-3, 0.5-3 parts of octapeptide-2, 1-8 parts of nutmeg pentapeptide-17, 0.1-3 parts of oligopeptide-1, 0.1-3 parts of oligopeptide-3, 1-4 parts of oligopeptide-5, 0.01-0.1 part of soluble collagen peptide, 50-80 parts of traditional Chinese medicine extracting solution and 3-12 parts of deionized water.
2. The method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect according to claim 1, wherein the Chinese medicinal extractive solution is mixed extractive solution of folium Platycladi, radix Angelicae sinensis, and Notoginseng radix.
3. The method for preparing essence containing polypeptide and plant extract with hair growth promoting effect according to claim 2, wherein the method for preparing the Chinese medicinal extract comprises the following steps:
(1) pretreatment: cleaning folium Platycladi, radix Angelicae sinensis, and Notoginseng radix, sun drying respectively, pulverizing, sieving, adding corresponding enzymolysis liquid, performing enzymolysis at certain temperature, performing microwave treatment to obtain pretreated powder, mixing, and placing in supercritical extraction device;
(2) supercritical extraction: adding a stabilizing agent and an extracting agent into a supercritical extraction device, mixing with the pretreated powder, and performing carbon dioxide supercritical extraction in the supercritical extraction device to obtain an extraction product;
(3) centrifuging to remove impurities: and (3) carrying out centrifugal separation on the extraction product, removing impurities, putting the extraction product in a rotary evaporator to evaporate the extractant, and adding deionized water to dilute the extraction product to obtain the traditional Chinese medicine extracting solution.
4. The method for preparing the essence containing the polypeptide and the plant extract liquid with the hair growth effect according to claim 3, wherein the enzymolysis liquid is a mixture of cellulase and pectinase with a mass ratio of 5:3, and the enzymolysis temperature is 40-60 ℃.
5. The method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect according to claim 3, wherein the stabilizer is catechin, and the extractant is ethanol.
6. The method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect according to claim 3, wherein the dilution is 5-15 times of the original extract.
7. The method for preparing essence containing polypeptide and plant extract with hair growth promoting effect according to claim 1, wherein the method for preparing the essence comprises the following steps: sequentially adding soluble collagen peptide, tripeptide-1 copper, acetyl tetrapeptide-3, nutmeg pentapeptide-17, octapeptide-2, oligopeptide-1, oligopeptide-3 and oligopeptide-5 into deionized water, adding one of the components, completely dispersing, adding the next component, finally adding the traditional Chinese medicine extracting solution, and uniformly mixing to obtain the essence.
8. The method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect according to claim 7, wherein the essence is prepared by adding wool acid into the Chinese medicinal extractive solution before mixing, emulsifying, and adding the mixture.
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|---|---|---|---|---|
| CN115252519A (en) * | 2022-08-03 | 2022-11-01 | 浙江熙正霖生物科技有限公司 | A hair care essence containing bioactive components and its preparation method |
| CN115317397A (en) * | 2022-09-23 | 2022-11-11 | 广西和桂集团有限公司 | Polypeptide-containing shampoo and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111658580A (en) * | 2020-06-23 | 2020-09-15 | 广西和桂集团有限公司 | Hair growth and/or hair blackening essence containing various peptides and plant extracts and preparation method thereof |
| CN112870333A (en) * | 2021-02-05 | 2021-06-01 | 广州诗美化妆品有限公司 | Composition and preparation for improving alopecia and promoting hair growth of human, and preparation method and application thereof |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111658580A (en) * | 2020-06-23 | 2020-09-15 | 广西和桂集团有限公司 | Hair growth and/or hair blackening essence containing various peptides and plant extracts and preparation method thereof |
| CN112870333A (en) * | 2021-02-05 | 2021-06-01 | 广州诗美化妆品有限公司 | Composition and preparation for improving alopecia and promoting hair growth of human, and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 佚名: "多肽生发冻干粉——多肽在生发上的应用", vol. 3, pages 251 - 253, Retrieved from the Internet <URL:http://www.360doc.com/content/21/0618/13/67733089_982595007.shtml> * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115252519A (en) * | 2022-08-03 | 2022-11-01 | 浙江熙正霖生物科技有限公司 | A hair care essence containing bioactive components and its preparation method |
| CN115317397A (en) * | 2022-09-23 | 2022-11-11 | 广西和桂集团有限公司 | Polypeptide-containing shampoo and preparation method thereof |
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