CN112842983B - Herbal emulsion for sensitive muscle repair and preparation method thereof - Google Patents
Herbal emulsion for sensitive muscle repair and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a herbal emulsion for sensitive muscle repair and a preparation method thereof, wherein the herbal emulsion is prepared from the following raw materials in percentage by weight: 20-30% of aloe-based functional component, 2-10% of tannin modifier, 2-5% of dipropylene glycol, 102-5% of polyglycerol, 1.2-2.0% of sodium hyaluronate, 0.05-0.1% of tremella polysaccharide, 0.025-0.075% of xanthan gum, 0.5-2% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5-3% of camellia seed oil, 0.5-3% of litsea cubeba oil, 0.05-0.1% of 1,2-hexanediol, and the balance of hot spring water; the functional component mainly containing Aloe is prepared from extracts of Aloe, trehalose, radix Ophiopogonis, radix et caulis Opuntiae Dillenii, radix Sophorae Flavescentis and flos Nelumbinis; the herbal emulsion for repairing the sensitive muscles, prepared by the invention, has a good allergy relieving and repairing effect on the skin, is free of additives, safe and non-irritant, does not exist in the existing market, can attract the eyes of consumers, and has the advantages of good repairing effect, simple preparation process and low preparation cost.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to herbal emulsion for repairing sensitive muscles and a preparation method thereof.
Background
The human face skin is thin and soft and elastic, contains more sebaceous glands, sweat glands, hair follicles, parotid ducts and abundant blood vessel motor nerves, and has extremely sensitive reaction when being stimulated by the outside; especially in modern society, more and more people have skin sensitivity problems due to the influence of the surrounding environment or the pressure of life.
Sensitive skin appears as a red network on the face after the stratum corneum becomes thinner and subcutaneous capillaries dilate blood stasis, and is a state of physiological hyperresponsiveness of the skin to environmental or internal factors rather than disease. Sensitive skin generally has the following skin characteristics: thin skin, facial or obvious red blood streaks; the skin is easily reddened and heated due to the temperature change caused by supercooling or overheating. Sensitive skin is generally not irritated by uv light, is easily irritated by environmental factors, seasonal changes and facial care products, is generally due to genetic factors, but is more sensitive due to the use of hormonal cosmetics and may be associated with general skin sensitivity.
According to a global research and study on more than 250000 people, sensitive skin in the global range is increasing, so that the market demand of anti-sensitive skin care products is increasing, the incidence rate of the sensitive skin in Asian women is 40% -55.98%, wherein the incidence rate of the women in China is 36.1%, while most herbal emulsions in the current market use tap water, and the tap water contains a large amount of minerals, heavy metals and the like, so that the herbal emulsions have a chronic stimulation effect on the skin and enable the skin to become dry and rough; the skin care product has large influence on sensitive muscles, and can cause dermatitis or eczema due to stimulation, block skin glands, influence normal metabolism and cause acne. Besides trace elements, the hot spring water contains rich minerals, and a beauty specialist card Luo Linna is also pointed out in the journal of women: the popularity of hot spring skin care products is closely related to the living states of modern people under the conditions of pressure, depression, pollution, water shortage and the like. Chronic acne, dry and astringent skin, deeper pigmentation and skin lacking elasticity all need a motivation to stimulate skin vitality. The hot spring contains hundreds of mineral substances such as potassium, sodium, calcium and the like, and can be a good product for helping skin metabolism and supplementing trace elements. Some microelements contained in hot spring water are proved to have good sedative and repairing effects, and mineral ions such as calcium, magnesium, strontium and the like in reasonable proportion can help the skin to establish defense capacity, so that skin care products taking hot spring water as a concept are further favored by sensitive muscle consumers. However, the instability of mineral ions in hot spring water causes the minerals in hot spring water to be difficult to be completely absorbed by skin.
Disclosure of Invention
In order to solve the technical problems that the nature of a spring water skin care product is unstable and mineral substances are difficult to absorb in the prior art, the invention provides a herbal emulsion for sensitive muscle repair and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a herbal emulsion for sensitive muscle repair is prepared from the following raw materials in percentage by weight: 20-30% of aloe-based functional component, 2-10% of tannin modifier, 2-5% of dipropylene glycol, 2-5% of polyglycerol-10%, 1.2-2.0% of sodium hyaluronate, 0.05-0.1% of tremella polysaccharide, 0.025-0.075% of xanthan gum, 0.5-2% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5-3% of camellia seed oil, 0.5-3% of litsea cubeba oil, 1,2-hexanediol, 0.05-0.1% of hot spring water in balance.
Further, the functional components mainly containing the aloe comprise the following raw materials in parts by weight:
further, the preparation method of the functional component mainly containing the aloe comprises the following steps:
a1, cleaning and airing fresh aloe, peeling, taking gel, pulping, centrifuging for 30-40min at 5000-6000r/min in a refrigerated centrifuge, refrigerating for 24-30h, performing ultrasonic treatment for 20-30min at the ultrasonic power of 80-100W and the temperature of 50-60 ℃, adding complex enzyme at the pH value of 5.0, performing ultrasonic treatment for 20-30min, inactivating enzyme, filtering, placing filtrate in the refrigerated centrifuge, centrifuging for 15-25min at 4000-5000r/min, concentrating at 50-55 ℃, washing precipitate with 75% ethanol solution by mass fraction, standing and centrifuging for multiple times, and taking supernatant to obtain aloe extract;
a2, mixing the radix ophiopogonis and the sophora flavescens root into a traditional Chinese medicine grinder for grinding, sieving the mixture by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, extracting for 30-40min under the conditions that the microwave temperature is 45-55 ℃ and the power is 600-800W, taking the precipitate, and repeating the step for 1 time; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix Ophiopogonis and radix Sophorae Flavescentis;
a3, mixing the prickly pear and the lotus flower into a traditional Chinese medicine grinder for grinding, sieving by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, extracting for 30-40min under the conditions that the microwave temperature is 45-55 ℃ and the power is 600-800W, and taking the precipitate and repeating the step for 1 time; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix et caulis Opuntiae Dillenii and flos Nelumbinis;
and A4, mixing trehalose, the aloe extract obtained in the step A1, the mixed extract of the radix ophiopogonis and the radix sophorae flavescentis obtained in the step A2 and the mixed extract of the twisted cactus and the lotus flowers obtained in the step A3 to obtain the herbal emulsion functional component.
Further, the complex enzyme in the step A1 is a mixture of pectinase, neutral protease and cellulase, wherein the addition amount of the pectinase is 0.5-1%, the addition amount of the neutral protease is 1-2%, and the addition amount of the cellulase is 1.5-2%.
Further, the mass ratio of the mixture in the step A2 to the ethanol with the volume fraction of 40% is 1; the mass ratio of the mixture to the ethanol with the volume fraction of 40% in the step A3 is 1.
Further, the temperature of the rotary evaporation in the steps A2 and A3 is 55-65 ℃, and the pressure is 0.9-0.95atm.
Further, in the step A4, the aloe extract, the trehalose, the mixed extract of the radix ophiopogonis and the radix sophorae flavescentis, the mixed extract of the twisted cactus and the lotus flower are mixed according to the mass ratio of (1.6-1.8) to (1.5-2) to (1).
Further, the tannin modified substance is prepared by the following method:
putting a tannic acid solution with the concentration of 0.05g/mL into a reaction container, putting the tannic acid solution into a constant-temperature water tank with the temperature of 55-65 ℃ for water bath heating, adding ammonium persulfate serving as an initiator, adding acetic acid with the mass concentration of 10% to adjust the pH of the tannic acid to 3.5-4.0, adding acrylic acid after reacting for 40-50min, and stirring for 1h to obtain the tannic acid modified substance.
Further, the mass ratio of the volume of the tannic acid to the ammonium persulfate is 0.5L; the addition amount of the acrylic acid is 1.2-1.5% of the tannin.
The invention also discloses a preparation method of the herbal emulsion for sensitive muscle repair, which specifically comprises the following steps:
s1: stirring and heating the camellia seed oil and the litsea cubeba oil to 80-85 ℃, preserving heat and stirring for more than 10min, and marking as phase I for later use;
s2: stirring and heating the tannin modified substance, dipropylene glycol, polyglycerol-10, sodium hyaluronate, tremella polysaccharide, xanthan gum and hot spring water to 80-85 ℃, preserving heat and stirring for more than 10min, and marking as phase II for later use;
s3: adding phase II into phase I, stirring for 3-5min, stopping stirring, and stirring for 1-3min;
s4: cooling the mixed solution after the homogenization reaction in the step S3 to 50-55 ℃, adding hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer and functional components mainly comprising aloe, and fully stirring and homogenizing for 2-5min;
s5: and (4) cooling the mixed solution after the homogenization reaction in the step S4 to 40-45 ℃, adding 1,2-hexanediol, and uniformly stirring to obtain the herbal emulsion for repairing the sensitive muscles.
Compared with the prior art, the invention has the following beneficial effects:
1. the emulsion disclosed by the invention is safe in property, meets the requirements on both sensory indexes and physical and chemical indexes, adopts various natural Chinese herbal medicine components as raw materials, has no stimulation to skin, and has multiple effects of diminishing inflammation, relieving itching, preserving moisture, resisting oxidation and bacteria, repairing sensitive muscles and the like; the aloe-containing functional components mainly comprise trehalose, radix ophiopogonis, roots of sophora flavescens ait, prickly pear and lotus flowers, have a repairing effect on skin, are mixed according to different proportions of raw materials, achieve a very good effect, and effectively improve sensitive muscles;
aloe extract: the aloin and aloesin contained in Aloe have skin beautifying effect, and have certain effects in keeping moisture, relieving inflammation, inhibiting bacteria, resisting allergy, softening skin, preventing acne, and astringing; aloe contains various components for eliminating superoxide free radical, such as superoxide dismutase and catalase, and has effects in caring skin, improving elasticity, preventing corrosion, and delaying aging; the aloe juice is natural extract, which contains various moisture-keeping components and nutritional components beneficial to human body; because the aloe contains glucose, mannose, uronic acid, calcium, hydrated protease, biological hormone, protein, amino acid, vitamin, mineral and other trace elements, the aloe has obvious effects of softening skin, astringing, preventing and treating acne, preventing pachylosis, diminishing inflammation, relieving itching, keeping skin delicate, white and clean and the like; the aloe has good compatibility, can be well matched with various cosmetic crystal raw materials, eliminates the damage of various surfactants to the skin, can prevent small wrinkles, eye bags and skin looseness, and can keep the skin moist and delicate; the aloe extract shows various biological activities, is an important additive of cosmetics, and has obvious skin-activating and anti-aging effects on the promotion of the aloe extract on the growth of fibrin, the inhibition of elastase, the promotion of the synthesis of collagen, the scavenging effect on hydroxyl free radicals and the like; the aloe extract has effects of promoting cholesterol synthesis, changing skin sebum composition, reducing gloss and increasing skin softness;
trehalose: trehalose is based on its excellent characteristics that keep cell activity and biological macromolecule activity, trehalose is not only the effect of moisturizing superstrong, when epidermal cell is in environment such as high temperature, it is dry, strong ultraviolet radiation, trehalose can form the special protection film of one deck on the cell top layer under this condition, keep the original nutrition of skin and moisture, add trehalose composition in the emulsion, let impaired skin barrier function obtain good maintenance, when improving fragile sensitive muscle, prevent skin moisture loss, effectively solve the dry problem of skin. And the skin is cared and simultaneously the maintenance is gradually started and the health state of the skin is maintained. The emulsion added with the trehalose is not sticky, has good skin absorption effect and excellent water replenishing and moisturizing effects;
radix ophiopogonis extract: the anti-drought skin cream is rich in active ingredients containing polyfructose, has strong anti-drought capability, and prevents excessive loss of skin moisture by strengthening adhesion of the upper layer of the epidermis and recombining the barrier function of the skin. The disintegration of the cuticle is reduced, and the moisturizing effect is achieved;
extract of kuh-seng root: the bath lotion has the effects of clearing heat, eliminating dampness and killing insects, the sophora flavescens can clear damp-heat in lower jiao, kill insects, relieve itching and well relieve skin itch, the plant Chinese herbal medicines can balance grease secretion, dredge and astringe pores, clear toxin impurities in skin, enrich the herbal nutrition, promote the growth and repair of damaged vascular nerve cells, recover the activity of subcutaneous capillary cells, and ensure that the skin is compact, fine and smooth, thereby playing the role of beautifying and protecting the skin;
extract of Opuntia ficus-indica: the twisted cactus has the concept of homology of medicine and food, and has the capabilities of preserving moisture and relieving sensitive skin for a long time due to the richness of polysaccharide, vitamins, mineral substances and the like; the prickly pear extract contains 18 amino acids, polysaccharides and various trace elements required by a human body, has good antioxidation and excellent water replenishing and moisture preserving capability, and can effectively improve the problems of dry peeling, external oil internal dryness, reddening sensitivity and the like caused by barrier damage and reduced water locking capability of skin;
lotus flower extract: the lotus extract contains vitamins and various nutritional ingredients, has various effects, contains various sugars and alcohols, can be used for moisturizing, can activate a moisturizing physiological storage program, has a risk coefficient of 1, is relatively safe, can be used safely, has no influence on pregnant women, and has no acne-causing property;
the plant extract has the advantages of nature, mildness and the like, but minerals in plants can be remained in the extract in the extraction process, so that the emulsion is easy to be unstable, the emulsion breaking phenomenon occurs, the product is easy to deteriorate and the like.
2. According to the invention, different extraction processes are adopted for different Chinese herbal medicines, so that active ingredients in the Chinese herbal medicines are more effectively retained, and the utilization rate of the Chinese herbal medicines is improved.
3. The hot spring water adopted by the invention is rich in minerals and trace elements such as calcium, magnesium and the like, can obviously inhibit cells from releasing histamine and prostaglandin D2 after antigen stimulation, relieves the discomfort of sensitive skin, can also adjust the fluidity of cell membranes, and can play a certain inhibiting effect on the release of inflammatory mediators. The skin moisturizing cream can neutralize acid and alkali stimulation, simultaneously toughens the skin barrier, has osmotic pressure similar to skin cells, can slowly release moisturizing factor components in the product in the skin on one hand, and stimulates the moisturizing factor contained in the skin cuticle to lock water on the other hand; however, the mineral ions in the hot spring water are unstable, so that the mineral ions in the hot spring water are difficult to be completely absorbed by skin, the mineral ions in the hot spring water are modified by acrylic acid graft copolymerization with the tannic acid, the mineral ions in the hot spring water can form complex precipitates with the tannic acid, other substances cannot, the tannic acid is rich in phenolic hydroxyl, and Zn can be better complexed by acrylic acid graft copolymerization 2+ 、Mg 2+ 、Ca 2+ The metal ions are added, so that the skin transmittance of the mineral ions is improved, the moisturizing and relieving effects are enhanced, and the problem of instability of the mineral ions in the prior art is solved; meanwhile, the molecular structure of the tannin contains a plurality of phenolic hydroxyl groups, and a large pi bond conjugate system and a strongly coordinated oxygen atom are arranged in the molecule, so that the tannin has stronger capability of complexing metal ions and is a good ligand of the metal ions due to the spatial configuration; and the electron-withdrawing action of the metal ions can promote the dissociation of H on the phenolic hydroxyl; in addition, tannic acid also has good antioxidant capacity, and the most prominent antioxidant properties are as follows: the complexing ability of metal ions, the elimination of free radicals and active oxygen, the regeneration and anti-allergy repair effects on endogenous antioxidants, and not only the gold is improved through the complexing of the metal ionsThe stable habit of the ions also enhances the oxidation resistance of the ions and can improve the skin permeability.
Detailed Description
In order to better understand the present invention, the following embodiments further illustrate the invention, the examples are only used to explain the invention, and do not constitute any limitation on the invention; unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are commercially available products.
Example 1
A herbal emulsion for sensitive muscle repair is prepared from the following raw materials in percentage by weight: 20% of aloe-based functional component, 2% of tannin modified substance, 5% of dipropylene glycol, 10% of polyglycerol, 2.0% of sodium hyaluronate, 0.05% of tremella polysaccharide, 0.025% of xanthan gum, 0.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5% of camellia seed oil, 0.5% of litsea cubeba oil, and 1,2-hexanediol, and the balance being 64.325% of hot spring water.
Wherein the functional components mainly containing aloe comprise the following raw materials in parts by weight: 35 parts of aloe, 20 parts of trehalose, 20 parts of radix ophiopogonis and 10 parts of twisted cactus; 10 parts of sophora flavescens roots and 10 parts of lotus flowers.
The preparation method of the functional component mainly comprising the aloe comprises the following steps:
a1, cleaning and airing fresh aloe, peeling, taking gel, pulping, centrifuging for 30min at 5000r/min in a refrigerated centrifuge, refrigerating for 24h, ultrasonically treating for 25min at the temperature of 50 ℃ under the ultrasonic power of 90W, adding complex enzyme under the condition that the pH is 5.0, ultrasonically treating for 25min, inactivating enzyme, filtering, centrifuging the filtrate for 25min at 4000r/min in the refrigerated centrifuge, concentrating at 50 ℃, washing and precipitating for multiple times by using 75% ethanol solution by mass fraction, standing and centrifuging, and taking supernatant to obtain aloe extract; the compound enzyme is a mixture of pectinase, neutral protease and cellulase, wherein the addition amount of the pectinase is 0.5%, the addition amount of the neutral protease is 1%, and the addition amount of the cellulase is 1.5%;
a2, mixing the radix ophiopogonis and the radix sophorae flavescentis, crushing the mixture in a traditional Chinese medicine crusher, sieving the mixture by a 40-mesh sieve to obtain a mixture, adding the mixture into 40% ethanol in a mass ratio of 1; filtering under reduced pressure, rotary evaporating at 55 deg.C and 0.9atm for concentration of 0.5g/mL to obtain mixed extractive solution of radix Ophiopogonis and radix Sophorae Flavescentis;
a3, mixing the prickly pear and the lotus flower into a traditional Chinese medicine grinder for grinding, sieving by a 40-mesh sieve to obtain a mixture, adding the mixture into 40% ethanol by mass, wherein the mass ratio of the mixture to the 40% ethanol by volume is 1; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix et caulis Opuntiae Dillenii and flos Nelumbinis;
and A4, mixing trehalose, the aloe extract obtained in the step A1, the mixed extract of radix ophiopogonis and radix sophorae flavescentis obtained in the step A2, and the mixed extract of twisted cactus and lotus flowers obtained in the step A3 according to a mass ratio of 1.8.
Wherein the tannin modifier is prepared by the following method: putting a tannic acid solution with the concentration of 0.05g/mL into a reaction container, putting the tannic acid solution into a constant-temperature water tank with the temperature of 55 ℃ for water bath heating, adding ammonium persulfate serving as an initiator, adding acetic acid with the mass concentration of 10% to adjust the pH of the tannic acid to 4.0, reacting for 50min, adding acrylic acid, and stirring for 1h to obtain a tannic acid modified substance; the mass ratio of the volume of the tannic acid to the ammonium persulfate is 0.5L; the addition amount of the acrylic acid is 1.4 percent of that of the tannic acid.
Example 2
A herbal emulsion for sensitive muscle repair is prepared from the following raw materials in percentage by weight: 30% of aloe-based functional component, 10% of tannin modified substance, 2% of dipropylene glycol, 10% of polyglycerol-10%, 1.2% of sodium hyaluronate, 0.1% of tremella polysaccharide, 0.075% of xanthan gum, 1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 3% of camellia seed oil, 3% of litsea cubeba oil and 0.05% of 1,2-hexanediol, and the balance being 46.575% of hot spring water.
The aloe extract is prepared from the following active ingredients in parts by weight: 40 parts of aloe, 30 parts of trehalose, 25 parts of radix ophiopogonis, 15 parts of twisted cactus, 12 parts of radix sophorae flavescentis and 13 parts of lotus.
The preparation method of the functional component mainly containing the aloe comprises the following steps:
a1, cleaning and airing fresh aloe, peeling, taking gel, pulping, centrifuging for 40min at 6000r/min in a refrigerated centrifuge, refrigerating for 26h, performing ultrasonic treatment for 2min at the ultrasonic power of 80W and the temperature of 60 ℃ and adding complex enzyme at the pH value of 5.0, performing ultrasonic treatment for 20min, inactivating enzyme, filtering, centrifuging filtrate for 15min at 5000r/min in the refrigerated centrifuge, concentrating at 55 ℃, washing and precipitating by using 75% ethanol solution in percentage by mass for multiple times, standing and centrifuging, and taking supernatant to obtain aloe extract; the complex enzyme is a mixture of pectinase, neutral protease and cellulase, wherein the addition amount of the pectinase is 1 percent, the addition amount of the neutral protease is 1.5 percent, and the addition amount of the cellulase is 2 percent;
a2, mixing the radix ophiopogonis and the sophora flavescens root into a traditional Chinese medicine grinder for grinding, sieving the mixture by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, wherein the mass ratio of the mixture to the ethanol with the volume fraction of 40% is 1; filtering under reduced pressure, rotary evaporating at 65 deg.C and 0.95atm to concentrate to concentration of 0.5g/mL to obtain mixed extractive solution of radix Ophiopogonis and radix Sophorae Flavescentis;
a3, mixing the twisted cactus and the lotus flowers into a traditional Chinese medicine grinder for grinding, sieving the mixture by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, wherein the mass ratio of the mixture to the ethanol with the volume fraction of 40% is 1; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix et caulis Opuntiae Dillenii and flos Nelumbinis;
a4, mixing the aloe extract, trehalose, the radix ophiopogonis and radix sophorae flavescentis mixed extract, the prickly pear and lotus flower mixed extract according to a mass ratio of 1.6.
Wherein the tannin modified substance is prepared by the following method: putting a tannic acid solution with the concentration of 0.05g/mL into a reaction container, putting the tannic acid solution into a constant-temperature water tank with the temperature of 65 ℃ for water bath heating, adding ammonium persulfate serving as an initiator, adding acetic acid with the mass concentration of 10% to adjust the pH of the tannic acid to 3.5, reacting for 45min, adding acrylic acid, and stirring for 1h to obtain a tannic acid modified substance; the mass ratio of the volume of the tannic acid to the ammonium persulfate is 0.5L; the addition amount of the acrylic acid is 1.5 percent of that of the tannic acid.
Example 3
A herbal emulsion for sensitive muscle repair is prepared from the following raw materials in percentage by weight: 25% of aloe-based functional component, 8% of tannin modifier, 3% of dipropylene glycol, 10% of polyglycerol, 1.8% of sodium hyaluronate, 0.08% of tremella polysaccharide, 0.05% of xanthan gum, 2% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2% of camellia seed oil, 2% of litsea cubeba oil, and 0.08% of 1,2-hexanediol, and the balance being 53.99% of hot spring water.
Wherein the functional components mainly containing aloe comprise the following raw materials in parts by weight: 50 parts of aloe, 35 parts of trehalose, 30 parts of radix ophiopogonis, 20 parts of twisted cactus, 15 parts of radix sophorae flavescentis and 15 parts of lotus flower.
The preparation method of the functional component mainly comprising the aloe comprises the following steps:
a1, cleaning and airing fresh aloe, peeling, taking gel, pulping, centrifuging for 35min at 5500r/min in a refrigerated centrifuge, refrigerating for 30h, performing ultrasonic treatment for 30min at the ultrasonic power of 100W and the temperature of 55 ℃, adding complex enzyme at the pH value of 5.0, performing ultrasonic treatment for 30min, inactivating enzyme, filtering, centrifuging filtrate for 20min at 4500r/min in the refrigerated centrifuge, concentrating at 52 ℃, washing precipitate with 75% ethanol solution by mass fraction, standing for multiple times, centrifuging, and taking supernatant to obtain aloe extract; the complex enzyme is a mixture of pectinase, neutral protease and cellulase, wherein the addition amount of the pectinase is 0.5 percent, the addition amount of the neutral protease is 2 percent, and the addition amount of the cellulase is 1.5 percent;
a2, mixing the radix ophiopogonis and the sophora flavescens root into a traditional Chinese medicine grinder for grinding, sieving the mixture by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, wherein the mass ratio of the mixture to the ethanol with the volume fraction of 40% is 1; filtering under reduced pressure, rotary evaporating at 60 deg.C under 0.92atm to concentrate to concentration of 0.5g/mL to obtain mixed extractive solution of radix Ophiopogonis and radix Sophorae Flavescentis;
a3, mixing the prickly pear and the lotus flower into a traditional Chinese medicine grinder for grinding, sieving by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, wherein the mass ratio of the mixture to the ethanol with the volume fraction of 40% is 1; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix et caulis Opuntiae Dillenii and flos Nelumbinis;
and A4, mixing the aloe extract, trehalose, the mixed extract of radix ophiopogonis and radix sophorae flavescentis, the mixed extract of twisted cactus and lotus flower according to the mass ratio of 1.7.
Wherein the tannin modified substance is prepared by the following method: putting a tannic acid solution with the concentration of 0.05g/mL into a reaction container, putting the tannic acid solution into a constant-temperature water tank with the temperature of 60 ℃ for water bath heating, adding ammonium persulfate serving as an initiator, adding acetic acid with the mass concentration of 10% to adjust the pH value of the tannic acid to 3.8, reacting for 40min, adding acrylic acid, and stirring for 1h to obtain a tannic acid modified substance; the mass ratio of the volume of the tannic acid to the ammonium persulfate is 0.5L; the addition amount of the acrylic acid is 1.2 percent of that of the tannic acid.
Example 4
A preparation method of herbal emulsion for sensitive muscle repair specifically comprises the following steps:
s1: the camellia seed oil and the litsea cubeba oil are stirred and heated to 80-85 ℃, and are stirred for more than 10min under the condition of heat preservation. Marking as I phase for standby.
S2: stirring and heating the tannin modified substance, dipropylene glycol, polyglycerol-10, sodium hyaluronate, tremella polysaccharide, xanthan gum and hot spring water to 80-85 ℃, and preserving heat and stirring for more than 10 min. Marking as phase II for standby.
S3: adding phase II into phase I, stirring and homogenizing for 3min, and stirring for 1min.
S4: cooling to 50 deg.C, adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and herbal effective components, stirring thoroughly, and homogenizing for 2min.
S5: cooling to 45 deg.C, adding 1,2-hexanediol, and stirring.
Comparative example 1
A herbal emulsion for sensitive muscle repair is prepared from the following raw materials in percentage by weight: 20% of aloe-based functional component, 2% of tannin modified substance, 5% of dipropylene glycol, 10% of polyglycerol, 2.0% of sodium hyaluronate, 0.05% of tremella polysaccharide, 0.025% of xanthan gum, 0.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5% of camellia seed oil, 0.5% of litsea cubeba oil, and 1,2-hexanediol, and the balance being 64.325% of hot spring water.
The aloe extract is prepared from the following active ingredients in parts by weight: 20 parts of trehalose, 20 parts of radix ophiopogonis and 10 parts of twisted cactus; 10 parts of sophora flavescens roots and 10 parts of lotus flowers.
The differences between comparative example 1 and example 1 are: the raw material for extracting the functional components does not contain aloe.
Comparative example 2
A herbal emulsion for sensitive muscle repair is prepared from the following raw materials in percentage by weight: 20% of aloe-based active ingredients, 5% of dipropylene glycol, 10% of polyglycerol, 2.0% of sodium hyaluronate, 0.05% of tremella polysaccharide, 0.025% of xanthan gum, 0.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5% of camellia seed oil, 0.5% of litsea cubeba oil, 0.1% of 1,2-hexanediol, and the balance of 66.325% of hot spring water.
Wherein the functional components mainly containing aloe comprise the following raw materials in parts by weight: 35 parts of aloe, 20 parts of trehalose, 20 parts of radix ophiopogonis and 10 parts of twisted cactus; 10 parts of sophora flavescens ait root and 10 parts of lotus flower.
The differences between comparative example 2 and example 1 are: the raw material components do not contain tannin modified substances.
Evaluation of Performance
1. Evaluation of allergy-relieving efficacy
Randomly screening 5 crowds with different ages and sexes, wherein the crowds are sensitive skins, the experimental group is coated with the herbal emulsion for sensitive muscle repair prepared according to the example 1, and the control group is coated with the herbal emulsion which does not contain aloe extract in the functional components prepared according to the comparative example 1; the left face and the right face of the same tester are respectively a control area and a test area, and the repairing effect of the invention is evaluated through sensory scores of the testers after use; the duration of the experiment was three months, and usage scores were collected weekly; the scoring is divided into four grades, 0-2 grades have little effect, 3-5 grades have effect, 5-8 grades have good effect, more than 8 grades have obvious effect, and the experimental results are as follows:
in conclusion, the herbal emulsion for sensitive muscle repair prepared according to example 1 has a significant improvement in sensitive muscles.
2. Determination of the stability constant
Taking 0.05mol/L tannic acid modified solution, zn 2+ 、Mg 2+ 、Ca 2+ Each 2.5mL of the solution was kept at an ionic strength of 0.10mol/L with NaCl solution and a constant volume of 100mL. The flask was transferred to a conical flask, placed in a constant temperature water bath and titrated with a NaOH standard solution under the protection of nitrogen. Obtaining tannin modified substance and oreThe logarithmic stability constant value of the complex formed by the ions is lgK. Formula for calculating the stability constant of the complex:
[L]＝((n-α)×CL-[H + ]+[OH a ])/(β1H×[H+]+2×β2H×[H+]2+…+n×βnH×[H+]n) formula (I):
- -average coordination number of the ligand L complexed to the metal, 1; cm- -total concentration of metal ions, mol/L
With [ L ]]Negative logarithm of pL pair
Making a generating function curve graph, wherein the pL value corresponding to the point with the element of a half integer is the logarithm value lgK of the complex stability constant; the logarithm of the stability constants of the tannic acid modified product and various metal ions is shown in the following table;
metal ion complexation stability constants of tannic acid modifications (lgK) table (I =0.1 mol/LNaCl)
In conclusion, the tannin modification liquid can be used for treating Zn at the same temperature 2+ 、Mg 2+ 、Ca 2+ The order of the complex size of (A) is Zn 2+ ＞Mg 2+ ＞Ca 2+ The tannin modified solution can well complex mineral ions.
3. Determination of emulsion stability
The experimental group was coated with the herbal emulsion for sensitive muscle repair prepared according to example 1, and the control group was coated with the herbal emulsion for sensitive muscle repair without tannin modification prepared according to comparative example 2;
3.1 stability Studies under high temperature storage conditions
Placing the mixture in an electric heating constant-temperature incubator at 40-50 ℃ for 30-50 days, and observing the stability of emulsions of an experimental group and a control group after the mixture is restored to room temperature, wherein the experimental results are shown in the following table;
stability study under high temperature storage conditions
3.2 high light irradiation test
Respectively placing the emulsions of the experimental group and the control group into an illumination box provided with a fluorescent lamp, placing the emulsions for 10 days under the condition that the illumination is 4500 +/-500 lx, observing the stability of the emulsions of the experimental group and the control group, and showing the experimental results in the following table;
stability study under intense light irradiation
3.3 centrifugal test
Respectively putting the emulsions of the experimental group and the control group into a centrifuge with the radius of 10cm, centrifuging for 5h at the rotating speed of 3750r/min, and observing the stability of the emulsions of the experimental group and the control group (which is equivalent to the result of one year of gravity action of geocentric), wherein the experimental results are shown in the following table;
stability study under centrifugation (gravitational force) conditions
The stability experiment results show that the herbal emulsion containing the tannin modifier and used for repairing the sensitive muscles, which is prepared according to the embodiment 1, has the characteristics and the color which are not changed under the conditions of high temperature, strong work light irradiation and centrifugation, the phenomena of precipitation, delamination and rancidity do not occur, the content of the effective component tannin modifier is not obviously changed, and the properties are stable.
The above description is only an embodiment of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structures or equivalent processes performed by the present invention or directly or indirectly applied to other related technical fields are also included in the scope of the present invention.
Claims (9)
1. The herbal emulsion for repairing sensitive muscles is characterized by being prepared from the following raw materials in percentage by weight: 20 to 30 percent of aloe-based functional component, 2 to 10 percent of tannin modifier, 2~5 percent of dipropylene glycol, 10 to 5 percent of polyglycerol, 1.2 to 2.0 percent of sodium hyaluronate, 0.05 to 0.1 percent of tremella polysaccharide, 0.025 to 0.075 percent of xanthan gum, 0.5 to 2 percent of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5 to 3 percent of camellia seed oil, 0.5 to 3 percent of litsea cubeba oil, 1,2-hexanediol, 0.05 to 0.1 percent of hot spring water and the balance of hot spring water; wherein the tannin modified substance is prepared by the following method: putting a tannic acid solution with the concentration of 0.05g/mL into a reaction container, putting the tannic acid solution into a constant-temperature water tank with the temperature of 55-65 ℃ for water bath heating, adding ammonium persulfate serving as an initiator, adding acetic acid with the mass concentration of 10% to adjust the pH of the tannic acid to 3.5-4.0, adding acrylic acid after reacting for 40-50min, and stirring for 1h to obtain the tannic acid modified substance.
2. A herbal emulsion for sensitive muscle repair as claimed in claim 1, wherein: the functional components mainly containing the aloe comprise the following raw materials in parts by weight:
35 to 50 parts of aloe;
20-35 parts of trehalose;
20-30 parts of radix ophiopogonis;
10 to 20 parts of twisted cactus;
10 to 15 parts of kushen root;
10 to 15 parts of lotus.
3. The herbal emulsion for sensitive muscle repair as claimed in claim 2, wherein the aloe vera-based active ingredient is prepared by the steps of:
a1, cleaning and airing fresh aloe, peeling, taking gel, pulping, centrifuging for 30-40min at 5000-6000r/min in a refrigerated centrifuge, refrigerating for 24-30h, performing ultrasonic treatment for 20-30min at the ultrasonic power of 80-100W and the temperature of 50-60 ℃, adding complex enzyme at the pH of 5.0, performing ultrasonic treatment for 20-30min, inactivating enzyme, filtering, placing filtrate in the refrigerated centrifuge, centrifuging for 15-25min at 4000-5000r/min, concentrating at 50-55 ℃, washing precipitate with 75% ethanol solution by mass fraction, standing and centrifuging for multiple times, and taking supernatant to obtain aloe extracting solution;
a2, mixing radix ophiopogonis and sophora flavescens root into a traditional Chinese medicine grinder for grinding, sieving by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, extracting for 30-40min under the conditions that the microwave temperature is 45-55 ℃ and the power is 600-800W, taking the precipitate, and repeating the extraction step for 1 time; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix Ophiopogonis and radix Sophorae Flavescentis;
a3, mixing the prickly pear and the lotus flower into a traditional Chinese medicine grinder for grinding, sieving by a 40-mesh sieve to obtain a mixture, adding the mixture into ethanol with the mass fraction of 40%, extracting for 30-40min under the conditions that the microwave temperature is 45-55 ℃ and the power is 600-800W, and taking the precipitate and repeating the step for 1 time; filtering under reduced pressure, rotary evaporating and concentrating to concentration of 0.5g/mL to obtain mixed extractive solution of radix et caulis Opuntiae Dillenii and flos Nelumbinis;
and A4, mixing trehalose, the aloe extract obtained in the step A1, the mixed extract of the radix ophiopogonis and the radix sophorae flavescentis obtained in the step A2 and the mixed extract of the twisted cactus and the lotus flowers obtained in the step A3 to obtain the herbal emulsion functional component.
4. A herbal emulsion for sensitive muscle repair as claimed in claim 3, wherein: the compound enzyme in the step A1 is a mixture of pectinase, neutral protease and cellulase, wherein the addition amount of the pectinase is 0.5-1%, the addition amount of the neutral protease is 1~2%, and the addition amount of the cellulase is 1.5-2%.
5. A herbal emulsion for sensitive muscle repair as claimed in claim 3, wherein: the mass ratio of the mixture to the ethanol with the volume fraction of 40% in the step A2 is 1; the mass ratio of the mixture to the ethanol with the volume fraction of 40% in the step A3 is 1.
6. A herbal emulsion for sensitive muscle repair as claimed in claim 3, wherein: the temperature of the rotary evaporation in the steps A2 and A3 is 55-65 ℃, and the pressure is 0.9-0.95atm.
7. A herbal emulsion for sensitive muscle repair as claimed in claim 3, wherein: in the step A4, mixing the aloe extract, trehalose, the mixed extract of radix ophiopogonis and radix sophorae flavescentis, the mixed extract of radix Opuntiae Dillenii and lotus flower according to the mass ratio of (1.6 to 1.8) to 1 (1.5 to 2) to 1.
8. A herbal emulsion for sensitive muscle repair as claimed in claim 1, wherein: the mass ratio of the volume of the tannic acid to the ammonium persulfate is 0.5L; the addition amount of the acrylic acid is 1.2-1.5% of the tannin.
9. The method for preparing herbal emulsion for sensitive muscle repair as claimed in claim 1, comprising the following steps:
s1: stirring and heating camellia seed oil and litsea cubeba oil to 80-85 ℃, preserving heat and stirring for more than 10min, and recording as phase I for later use;
s2: stirring and heating tannin modified substances, dipropylene glycol, polyglycerol-10, sodium hyaluronate, tremella polysaccharide, xanthan gum and hot spring water to 80-85 ℃, and keeping the temperature and stirring for more than 10min, and marking as phase II for later use;
s3: adding phase II into phase I, stirring for 3-5min, stopping stirring, and stirring for 1-3min;
s4: cooling the mixed solution after the homogenization reaction in the step S3 to 50-55 ℃, adding hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer and functional components mainly comprising aloe, and fully stirring and homogenizing for 2-5min;
s5: and (4) cooling the mixed solution subjected to the homogenization reaction in the step S4 to 40-45 ℃, adding 1,2-hexanediol, and uniformly stirring to obtain the herbal emulsion for repairing the sensitive muscles.
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