CN110721117A - Freeze-dried powder preparation of beauty and skin care cosmetics and application of freeze-dried powder preparation in solution - Google Patents
Freeze-dried powder preparation of beauty and skin care cosmetics and application of freeze-dried powder preparation in solution Download PDFInfo
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Abstract
The invention relates to a beauty and skin care cosmetic freeze-dried powder preparation and application thereof in solution, wherein the beauty and skin care cosmetic freeze-dried powder preparation is prepared from the following raw material components in percentage by mass: hyaluronic acid: 1% -5%, antibacterial peptide: 0.001% -0.005%, excipient: 5% -15%, water: 79.995-93.999% of the raw materials are stirred, heated and dissolved completely, and then the mixture is sublimated by a freeze-drying technology to obtain the freeze-dried powder preparation. The lyophilized powder preparation can be applied to stock solution, essence solution, enzyme solution or liquid dressing. The invention can avoid the phenomena of unbalanced water and oil of the skin, easy pore blockage and the like, simultaneously improves the stability of the antibacterial peptide in the antibacterial peptide, exerts the antibacterial and anti-inflammatory effects of the antibacterial peptide to prevent the occurrence and development of acne, and better realizes the function of repairing the skin.
Description
Technical Field
The invention relates to a substance for a beauty and skin care cosmetic, in particular to a freeze-dried powder preparation for the beauty and skin care cosmetic.
Background
Hyaluronic acid, namely hyaluronic acid, is a natural biomolecule widely existing in skin and other tissues, has an excellent moisturizing effect, is internationally an ideal natural moisturizing factor, and is a substance with the best moisturizing performance for cosmetics found in nature at present. Hyaluronic acid has effects of improving skin nutrition metabolism, making skin tender and smooth, removing wrinkle, increasing elasticity, and preventing aging. Meanwhile, hyaluronic acid is one of main matrixes of epidermis and dermis of human skin, and the physiological function of hyaluronic acid enables water to enter intercellular spaces and be combined with protein to form protein gel, so that cells are adhered together, the metabolism of normal cells is exerted, the water of the cells is kept, the cells are protected from being invaded by pathogenic bacteria, the recovery of skin tissues is accelerated, the regeneration capacity of wounds is improved, scars are reduced, the immunity is enhanced, and the like.
In order to meet the requirements of consumers, a large amount of skin nourishing ingredients are added into freeze-dried powder or lysozyme solution, hyaluronic acid is one of the ingredients, hyaluronic acid exists as the ingredient in freeze-dried powder lysozyme at present, the molecular weight of hyaluronic acid determines the absorption degree, and generally, the existing freeze-dried powder raw material added with the hyaluronic acid ingredient is applied to cosmetics and skin care products, so that the conditions of water and oil imbalance, pore blockage and skin inflammation of the skin are easily caused, acne is even caused, and the red and itchy symptoms of sensitive skin are also easily caused.
Disclosure of Invention
In order to overcome the defects of the application of the existing hyaluronic acid in the beauty and skin care cosmetics, the invention provides a beauty and skin care cosmetic freeze-dried powder preparation and application thereof in a solution.
The invention aims to provide a beauty skin care cosmetic freeze-dried powder preparation which is prepared from the following raw material components in percentage by mass:
hyaluronic acid: 1 to 5 percent
Antibacterial peptide: 0.001% -0.005%
Excipient: 5 to 15 percent of
Water: 79.995-93.999 percent
Further, the compound also comprises sodium chloride: 0.02% -0.04%.
Further, the hyaluronic acid comprises: sodium hyaluronate, hyaluronic acid, cross-linked sodium hyaluronate, ultramicro molecular hyaluronic acid, ultramicro molecular sodium hyaluronate, ultramicro molecular hyaluronic acid, oligomeric sodium hyaluronate, enzymolysis hyaluronic acid or enzyme-digested hyaluronic acid, and enzyme-digested sodium hyaluronate.
Further, the antibacterial peptide comprises a bungarus fasciatus antibacterial peptide Cath-BF, an antibacterial peptide Cath-BF, a bungarus fasciatus antibacterial peptide, an antibacterial polypeptide, an antibacterial peptide Cath-BF30, an antibacterial peptide Cath-BF34, a plant antibacterial peptide, an enzymolysis antibacterial peptide, an animal antibacterial peptide, a hybrid antibacterial peptide, an antibacterial peptide LL-37, an antibacterial peptide KS26, a dandelion antibacterial peptide, a cecropin antibacterial peptide, a bungarus fasciatus antibacterial peptide Cathelicidin-BF, a cobra antibacterial peptide Cathelicidin-NA and a cobra antibacterial peptide Cathelicidin-OH.
Further, the excipient is mannitol, sorbitol or trehalose.
Further, the method is applied to stock solution, essence, solution or liquid dressing.
The application of the freeze-dried powder preparation of the beauty and skin care cosmetics for realizing the aim of the invention in the stock solution is as follows: the composite material comprises the following components in percentage by mass:
solvent: 85.25 percent
The beauty skin care cosmetic freeze-dried powder preparation comprises the following components: 5 percent of
Humectant: 6 percent of
Thickening agent: 0.1
Raw materials: 3.05 percent
PH regulator triethanolamine 0.1
Antiseptic p-hydroxyacetophenone 0.5
The solvent described above is 85.25% water (deionized water); the humectant is as follows: 1.5% propylene glycol, 1.5% butylene glycol, 1.5% 1, 2-hexanediol, and 1.5% glyceryl polyether-26; the thickener is 0.1% carbomer; the raw materials comprise 1% of peony extract, 2% of hydrolyzed sodium hyaluronate (5000D) and 0.05% of fullerene; the pH regulator is 0.1% triethanolamine; the preservative is 0.5 percent of p-hydroxyacetophenone.
Specifically, the stock solution comprises the following components in percentage by mass:
the freeze-dried powder preparation for the beauty and skin care cosmetics comprises the following components: 5 percent of,
Hydrolysis of sodium hyaluronate: 2 percent of
Propylene glycol: 1.5 percent
Butanediol: 1.5 percent
Glyceryl polyether-26: 1.5 percent
1, 2-hexanediol: 1.5 percent
Peony root extract: 1 percent of
Carbomer: 0.1 percent of
P-hydroxyacetophenone: 0.5 percent
Triethanolamine: 0.1 percent of
Fullerene: 0.05 percent
Water: 85.25 percent
The application of the freeze-dried powder preparation of the beauty and skin care cosmetics for realizing the aim of the invention in the stock solution is as follows: the essence consists of the following components in percentage by mass:
the freeze-dried powder preparation for the beauty and skin care cosmetics comprises the following components: 5 percent of,
1, 3-butanediol: 3 to 5 percent
Butanediol: 3 to 5 percent
Glycyrrhiza glabra root extract: 1 to 3 percent of
Sodium hyaluronate: 0.5 to 1 percent
Palmitoyl tripeptide-1: 0.002% -0.005%
Oligopeptide-1: 0.1 to 0.2 percent
Oligopeptide-3: 0.01 to 0.05 percent
Placenta hydrolysate: 0.01 to 0.05 percent
P-hydroxy-phenyl-acetone: 0.02% -0.05%
Water: 85.645-92.358 percent
The application of the freeze-dried powder preparation of the beauty and skin care cosmetics for realizing the aim of the invention in the gel is as follows: the gel consists of the following components in percentage by mass:
the beauty skin care cosmetic freeze-dried powder preparation comprises the following components: 5 percent of
Solvent: 81.18 percent
Humectant: 10.72 percent
PH regulator triethanolamine 0.1
Film-forming agent: 3 percent of
The solvent is as follows: 71.18% water (deionized water) and 10% methyl propylene glycol; the humectant comprises the following components: is prepared from 5% glycerol, 1.5% butanediol, 1% 1, 2-hexanediol, 0.05% ceramide 1, 1% glyceryl polyether-26, 0.05% oligopeptide-1, 0.05% oligopeptide-6, 0.5% soluble collagen, 0.5% yellow collagen, 1% hydrolyzed hyaluronic acid, 0.01% asiaticoside, 0.05% Cordygulin leaf extract, and 0.01% horse chestnut extract; the pH regulator is triethanolamine; the film forming agent is acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer.
Specifically, the gel comprises the following components in percentage by mass:
the beauty skin care cosmetic freeze-dried powder preparation is adopted: 5 percent of
Glycerol: 5 percent of
Propylene glycol: 1.5 percent
Butanediol: 1.5 percent
Ceramide 1: 0.05 percent
Glyceryl polyether-26: 1 percent of
1, 2-hexanediol: 1 percent of
Oligopeptide-1: 0.05 percent
Oligopeptide-6: 0.05 percent
Soluble collagen: 0.5 percent
Collagen yellow: 0.5 percent
Hydrolysis of hyaluronic acid: 1 percent of
Asiaticoside: 0.01 percent
Vitis vinifera leaf clematis leaf extract: 0.05 percent
Horse chestnut extract: 0.01 percent
P-hydroxyacetophenone: 0.01 percent
Triethanolamine: 0.1 percent.
Water: 83.66 percent
The invention has the following beneficial effects:
1. the hyaluronic acid and the antibacterial peptide are combined for use, and the antibacterial peptide is a micromolecular polypeptide with biological activity and has the characteristics of small molecular weight, good water solubility, high temperature resistance, strong antibacterial property, low immunity and antigenicity and the like. And the antibacterial peptide molecules of the antibacterial peptide can perforate the cell membrane of bacteria to form an ion channel, so that the cell membrane is damaged, and water-soluble substances in the cells can seep out. The basic structure of hyaluronic acid is a large polysaccharide composed of two disaccharide units, D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid belongs to polysaccharides, a series of chemical reactions such as deamidation, beta-elimination, hydrolysis and the like occur in the freeze-drying process of hyaluronic acid and antibacterial peptide, the polypeptide forms hydrogen bonds to stabilize the natural structure of the polypeptide, and the vitrification temperature of a freeze-dried product is also increased. During the process of mixing, stirring, heating and dissolving the sodium hyaluronate with the antibacterial peptide, a plurality of disaccharide units D-glucuronic acid and N-acetylglucosamine are broken and cut into single disaccharide units D-glucuronic acid and N-acetylglucosamine, so that the molecular weight of the hyaluronic acid is reduced to about 1000 daltons. Even if the composition of the hyaluronic acid and the antibacterial peptide is used, the molecular weight of the hyaluronic acid is reduced, the hyaluronic acid can permeate into the dermis of the skin, the hyaluronic acid is absorbed by the dermis to achieve a better beautifying and skin-care effect, the phenomena of unbalanced water and oil of the skin, easy pore blockage and the like are avoided, meanwhile, the stability of the antibacterial peptide in the antibacterial peptide is improved, the antibacterial and anti-inflammatory effects of the antibacterial peptide are exerted, acne is prevented from occurring and developing, and the skin repairing function is achieved better.
2. The sodium hyaluronate can permeate into the dermis layer of the skin, supplement moisture of the skin, keep the skin tender and smooth, increase the number and proliferation of fibroblasts, promote the formation of collagen fibers and reticular fibers, and recover and keep the skin elasticity.
3. The antibacterial peptide can improve skin microcirculation and lymphatic circulation, regulate skin metabolism, inhibit elastase expression, reduce enzymolysis of elastin, kill propionibacterium acnes, staphylococcus aureus and streptococcus, prevent and reduce skin infection and reduce acne.
5. The hyaluronic acid and the antibacterial peptide are combined for use, so that the skin care product has the functions of repairing skin barriers, improving skin immunity, whitening and brightening skin, preventing ultraviolet rays, clearing free radicals, reducing lipid oxidation, keeping skin elasticity, reducing wrinkles and delaying skin aging.
Drawings
FIG. 1 is a schematic diagram of hyaluronic acid cleavage by binding of hyaluronic acid and an antimicrobial peptide according to the present invention.
Detailed Description
The invention will be further illustrated with reference to the following specific examples:
example 1:
a freeze-dried powder preparation of a cosmetic for beauty and skin care is prepared from the following raw material components in percentage by mass:
hyaluronic acid: 3 percent of
Antibacterial peptide F: 0.003%
Excipient: 10 percent of
Water: 86.997 percent
The raw materials are stirred, heated and completely dissolved, and then the freeze-dried powder preparation is obtained by sublimation through a freeze-drying technology, and can be applied to stock solution, essence, enzyme solution or liquid dressing.
The hyaluronic acid comprises: sodium hyaluronate, hyaluronic acid, cross-linked sodium hyaluronate, ultramicro molecular hyaluronic acid, ultramicro molecular sodium hyaluronate, ultramicro molecular hyaluronic acid, oligomeric sodium hyaluronate, enzymolysis hyaluronic acid or enzyme-digested hyaluronic acid, and enzyme-digested sodium hyaluronate. The excipient is mannitol, sorbitol or trehalose.
The antibacterial peptide comprises a bungarus fasciatus antibacterial peptide Cath-BF, an antibacterial peptide Cath-BF, a bungarus fasciatus antibacterial peptide, an antibacterial polypeptide, an antibacterial peptide Cath-BF30, an antibacterial peptide Cath-BF34, a plant antibacterial peptide, an enzymolysis antibacterial peptide, an animal antibacterial peptide, a hybrid antibacterial peptide, an antibacterial peptide LL-37, an antibacterial peptide KS26, a dandelion antibacterial peptide, a cecropin antibacterial peptide, a bungarus fasciatus antibacterial peptide Cathelicidin-BF, a cobra antibacterial peptide Cathelicidin-NA and a cobra antibacterial peptide Cathelicidin-OH.
When the antibacterial peptide is specifically applied, a large number of disaccharide units D-glucuronic acid and N-acetylglucosamine are broken in the process of mixing, stirring, heating and dissolving the sodium hyaluronate and the antibacterial peptide, and the sodium hyaluronate is cut into single disaccharide units D-glucuronic acid and N-acetylglucosamine, so that the molecular weight of the hyaluronic acid is reduced to about 733-1000 daltons. Therefore, the composition of the hyaluronic acid and the antibacterial peptide promotes the molecular weight of the hyaluronic acid to be reduced, namely, the sodium hyaluronate molecules are split and the molecules are reduced, so that the hyaluronic acid can permeate into the dermis of the skin and be absorbed by the dermis to realize better beautifying and skin-care effects, the phenomena of unbalanced water and oil of the skin, easy pore blockage and the like are avoided, meanwhile, the stability of the antibacterial peptide in the antibacterial peptide is improved, the antibacterial and anti-inflammatory effects of the antibacterial peptide are exerted, the acne is prevented from occurring and developing, and the skin repairing function is better realized.
In specific application, 1 g of the freeze-dried powder preparation prepared by the method is respectively and directly mixed with acceptable matrixes of 5000ML, 200ML and 50ML stock solutions, essence solutions, enzyme solutions or liquid dressings and other beauty and skin care products and is applied after being completely dissolved.
In order to prove the effect of the hyaluronic acid and the antibacterial peptide in combination, the freeze-dried powder preparation is added into a cosmetic solution for experiment, and three groups of the same cosmetic solution with the concentration of 20mg/ml, 5.0mg/ml and 0.2mg/ml are obtained after complete dissolution. Test reference strains: propionibacterium acnes, Staphylococcus aureus, Streptococcus, and Escherichia coli were all provided by the pharmaceutical laboratories of southern medical university. The culture medium includes YPD culture medium, low-salt LB culture medium, trace element solution, liquid FT culture medium, anaerobic culture box, agar, etc. The sterilization effect of the composition is identified by a transparent spot method, the size of a bacteriostasis zone is observed, and the bacterial count is detected. The result is: the three compositions with different concentrations have different bacteriostatic effects on propionibacterium acnes, staphylococcus aureus, escherichia coli and streptococcus, the higher the concentration is, the stronger the bactericidal effect is, and the antibacterial peptide has obvious effects on propionibacterium acnes, staphylococcus aureus and streptococcus albus. As shown in the table below.
Bacteria count test results
Note: 1,2 and 3 in the sequence numbers respectively represent 0.2mg/ml, 5.0mg/ml and 20mg/ml concentration solution
Example 2:
the technical characteristics of this embodiment are: the beauty skin care cosmetic freeze-dried powder preparation is prepared from the following raw material components in percentage by mass:
hyaluronic acid: 1 to 5 percent
Antibacterial peptide: 0.001% -0.005%
Sodium chloride: 0.02% -0.04%
Excipient: 5 to 15 percent of
Water: 79.995-93.999 percent
Specifically, the beauty skin care cosmetic freeze-dried powder preparation is prepared from 5% of hyaluronic acid, 0.005% of antibacterial peptide, 0.02% of sodium chloride, 5% of excipient and 89.975% of water.
The raw materials are stirred, heated and completely dissolved, and then are sublimated by a freeze-drying technology to obtain a freeze-dried powder preparation, and the rest is the same as the above embodiment.
Example 3:
the application of the freeze-dried powder preparation of the beauty and skin care cosmetics in the essence is as follows: the essence consists of the following components in percentage by mass:
the beauty skin care cosmetic freeze-dried powder preparation adopting the technology comprises the following components: 5 percent of,
1, 3-butanediol: 3 to 5 percent
Butanediol: 3 to 5 percent
Glycyrrhiza glabra root extract: 1 to 3 percent of
Sodium hyaluronate: 0.5 to 1 percent
Palmitoyl tripeptide-1: 0.002% -0.005%
Oligopeptide-1: 0.1 to 0.2 percent
Oligopeptide-3: 0.01 to 0.05 percent
Placenta hydrolysate: 0.01 to 0.05 percent
P-hydroxy-phenyl-acetone: 0.02% -0.05%
Water: 85.645-92.358 percent
Example 4:
the application of a freeze-dried powder preparation of a cosmetic for skin care in stock solution is as follows: a stock solution comprises the following components in percentage by mass:
the preparation method comprises the following steps:
1. uniformly stirring water, glyceryl polyether-26, propylene glycol, butanediol, 1, 2-hexanediol and carbomer, heating to 85 ℃, fully dissolving, and stirring for 30 minutes under heat preservation.
2. Adding hydrolyzed sodium hyaluronate (5000D) into emulsifying pot, dispersing, and heating.
3. Cooling the mixture obtained in the step 1 to 45 ℃, adding the peony extract, the fullerene, the hydrolyzed sodium hyaluronate dispersed in the step 2 and the beauty and skin care cosmetic freeze-dried powder preparation, uniformly stirring, and keeping the temperature and stirring for 15 minutes.
4. And (3) adding the mixture obtained in the step (3) into triethylamine alcohol and p-hydroxyacetophenone, and stirring for 15 minutes to obtain the final product.
In an embodiment, the stock solution further comprises one or more of grease, a humectant, a surfactant, a physiological substance, a plant extract, an animal extract or a trace element preservative.
The oil is one or more of squalane, lanolin, olive oil, jojoba oil, soybean oil, snake oil, carnauba wax, oleic acid, oleum Hippophae, oleum gossypii semen, polymethylphenylsiloxane, cyclic polysiloxane or hydrogenated castor oil.
The humectant is any one or more of glycerol, fructo-oligosaccharide, xylitol, propylene glycol, butanediol, hexanediol, betaine, glycerol polyacrylate or methyl glycine proline.
The surfactant is one or more of polyethylene glycol, sodium oleate, lanonol ester derivatives, polyoxyethylene lauryl alcohol ether, lauryl glyceryl stearate, lecithin or phosphate ester salt.
The physiological substance is one or more of vitamins (vitamin B1, vitamin C, vitamin E, nicotinic acid, etc.), amino acids (L-tyrosine, L-tryptophan, glutamic acid, etc.), superoxide dismutase or epidermal growth factor.
The plant extract is one or more of fructus Hippophae extract, Glycyrrhiza glabra extract, radix Paeoniae extract, rhizoma Ligustici Chuanxiong extract, fructus Vitis Viniferae extract or fructus Mali Pumilae extract.
The animal extract is one or more of animal hydrolyzed protein, silk extract, propolis, cornu Cervi Pantotrichum extract or placenta hydrolysate.
The trace elements are any one or more of iron, zinc, manganese, cobalt, magnesium, molybdenum, selenium or calcium.
The antiseptic is one or more of sodium benzoate, sorbic acid, p-hydroxybenzoate esters, benzoic acid, p-hydroxy-propyl ketone, dimethyl hydroxymethyl pyrazole, ethylparaben or phenoxyethanol.
Example 5:
the application of a freeze-dried powder preparation of a cosmetic for skin care in gel is as follows: the gel consists of the following components in percentage by mass:
the preparation method comprises the following steps:
stirring deionized water, methyl propylene glycol, glycerol, butanediol, and 1, 2-hexanediol, heating to 85 deg.C, dissolving completely, and stirring for 30 min. Cooling the mixture to 45 ℃, sequentially adding ceramide 1, glyceryl polyether-26, oligopeptide-1, oligopeptide-6, soluble collagen, hydrolyzed hyaluronic acid, asiaticoside, a cauliflower leaf extract, a horse chestnut extract, triethanolamine, the beauty and skin care cosmetic freeze-dried powder preparation and an acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, uniformly stirring for 15 minutes, and preserving heat to obtain the beauty and skin care cosmetic.
In an embodiment, the stock solution further comprises one or more of grease, a humectant, a surfactant, a physiological substance, a plant extract, an animal extract or a trace element preservative.
The oil is one or more of squalane, lanolin, olive oil, jojoba oil, soybean oil, snake oil, carnauba wax, oleic acid, oleum Hippophae, oleum gossypii semen, polymethylphenylsiloxane, cyclic polysiloxane or hydrogenated castor oil.
The humectant is any one or more of glycerol, fructo-oligosaccharide, xylitol, propylene glycol, butanediol, hexanediol, betaine, glycerol polyacrylate or methyl glycine proline.
The surfactant is one or more of polyethylene glycol, sodium oleate, lanonol ester derivatives, polyoxyethylene lauryl alcohol ether, lauryl glyceryl stearate, lecithin or phosphate ester salt.
The physiological substance is one or more of vitamins (vitamin B1, vitamin C, vitamin E, nicotinic acid, etc.), amino acids (L-tyrosine, L-tryptophan, glutamic acid, etc.), superoxide dismutase or epidermal growth factor.
The plant extract is one or more of fructus Hippophae extract, Glycyrrhiza glabra extract, radix Paeoniae extract, rhizoma Ligustici Chuanxiong extract, fructus Vitis Viniferae extract or fructus Mali Pumilae extract.
The animal extract is one or more of animal hydrolyzed protein, silk extract, propolis, cornu Cervi Pantotrichum extract or placenta hydrolysate.
The trace elements are any one or more of iron, zinc, manganese, cobalt, magnesium, molybdenum, selenium or calcium.
The antiseptic is one or more of sodium benzoate, sorbic acid, p-hydroxybenzoate esters, benzoic acid, p-hydroxy-propyl ketone, dimethyl hydroxymethyl pyrazole, ethylparaben or phenoxyethanol.
To demonstrate the effectiveness of the stock solutions and gels of the invention applied to cosmetic skin care products, the applicant made the following experiments:
the test method comprises the following steps: screening at least 20 people with face allergy (redness and itching), wherein the age range of the people is 18-45 years due to overuse or improper use of cosmetics, applying the beauty and skin care cosmetic freeze-dried powder preparation of the invention as a sample group by using one side face without applying the beauty and skin care cosmetic freeze-dried powder preparation of the invention as a blank control (the following table is a control group), and testing the skin moisture content, the skin moisture loss and the skin heme value on 0 day, 7 day, 14 day and 28 day respectively, wherein the indexes are used for evaluating the skin repairing capability and the continuous water replenishing capability of the beauty and skin care cosmetic freeze-dried powder preparation of the invention.
20 volunteers were recruited for the experiment, the skin was in the red and itchy state, the barrier function of the skin was destroyed, and the skin moisture, TEWL value and heme value of 20 volunteers were all similar. The data below are averaged in whole.
The results are shown in the following tables:
skin Water content/C.U
As a result: there was a significant increase in skin moisture content on the sample side compared to the control side after 4 weeks of use.
Skin Water loss (TEWL)/g/hm2
As a result: compared to the control, after 4 weeks using the combination of examples, the skin barrier function was significantly restored to normal and the skin water loss was significantly reduced.
While the invention has been described with reference to specific embodiments, the scope of the invention is not limited thereto, and any changes, modifications, substitutions, combinations, and simplifications that may be made by those skilled in the art without departing from the scope of the invention are intended to be included within the scope of the invention.
Claims (9)
1. A freeze-dried powder preparation of a cosmetic for beauty and skin care is characterized in that: the material is prepared from the following raw materials in percentage by mass:
hyaluronic acid: 1 to 5 percent
Antibacterial peptide: 0.001% -0.005%
Excipient: 5 to 15 percent of
Water: 79.995-93.999 percent
The raw materials are stirred, heated and dissolved completely, and then the freeze-dried powder preparation is obtained by sublimation through a freeze-drying technology.
2. The lyophilized powder formulation for beauty and skin care cosmetics according to claim 1, wherein: also comprises sodium chloride: 0.02% -0.04%.
3. The lyophilized powder formulation for beauty and skin care cosmetics according to claim 1, wherein: the hyaluronic acid comprises: sodium hyaluronate, hyaluronic acid, cross-linked sodium hyaluronate, ultramicro molecular hyaluronic acid, ultramicro molecular sodium hyaluronate, ultramicro molecular hyaluronic acid, oligomeric sodium hyaluronate, enzymolysis hyaluronic acid or enzyme-digested hyaluronic acid, and enzyme-digested sodium hyaluronate.
4. The lyophilized powder formulation for cosmetic skin care according to claim 1,2 or 3, wherein: the antibacterial peptide comprises bungarus fasciatus antibacterial peptide Cath-BF, bungarus fasciatus antibacterial peptide, antibacterial polypeptide, antibacterial peptide Cath-BF30, antibacterial peptide Cath-BF34, plant antibacterial peptide, enzymolysis antibacterial peptide, animal antibacterial peptide, hybrid antibacterial peptide, antibacterial peptide LL-37, antibacterial peptide KS26, dandelion antibacterial peptide, cecropin antibacterial peptide, bungarus fasciatus antibacterial peptide Cathelicidin-BF, cobra antibacterial peptide Cathelicidin-NA and cobra antibacterial peptide Cathelicidin-OH.
5. The lyophilized powder formulation for cosmetic skin care according to claim 1,2 or 3, wherein: the excipient is mannitol, sorbitol or trehalose.
6. The lyophilized powder formulation for beauty and skin care cosmetics according to claim 5, wherein: the method is applied to stock solution, essence, enzyme solution or liquid dressing.
7. A stock solution, characterized by: the composite material comprises the following components in percentage by mass:
solvent: 85.25 percent
The cosmetic skin-care cosmetic lyophilized powder preparation of any one of claims 1 to 5: 5 percent of
Humectant: 6 percent of
Thickening agent: 0.1
Raw materials: 3.05 percent
PH regulator triethanolamine 0.1
0.5 of p-hydroxyacetophenone preservative.
8. The essence is characterized in that: the composite material comprises the following components in percentage by mass:
the cosmetic skin-care cosmetic lyophilized powder preparation of any one of claims 1 to 5: 5 percent of
1, 3-butanediol: 3 to 5 percent
Butanediol: 3 to 5 percent
Glycyrrhiza glabra root extract: 1 to 3 percent of
Sodium hyaluronate: 0.5 to 1 percent
Palmitoyl tripeptide-1: 0.002% -0.005%
Oligopeptide-1: 0.1 to 0.2 percent
Oligopeptide-3: 0.01 to 0.05 percent
Placenta hydrolysate: 0.01 to 0.05 percent
P-hydroxy-phenyl-acetone: 0.02% -0.05%
Water: 85.645-92.358 percent.
9. A gel characterized by: the composite material comprises the following components in percentage by mass:
the cosmetic skin-care cosmetic lyophilized powder preparation of any one of claims 1 to 5: 5 percent of
Solvent: 81.18 percent
Humectant: 10.72 percent
PH regulator triethanolamine 0.1
Film-forming agent: 3 percent.
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