CN108434080A - A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells - Google Patents
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells Download PDFInfo
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- CN108434080A CN108434080A CN201810570015.XA CN201810570015A CN108434080A CN 108434080 A CN108434080 A CN 108434080A CN 201810570015 A CN201810570015 A CN 201810570015A CN 108434080 A CN108434080 A CN 108434080A
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- striae
- hyaluronic acid
- stem cells
- epidermal stem
- pregnancy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of striae of pregnancy repairing pastes of extract containing epidermal stem cells, are calculated by mass percentage, contain following components：The key compound 0.005~5.0% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.1~5.0%, epidermal stem cells extract 0.5~9.0%, coix seed polypeptide 0.001~5.0%, palmitoyl oligopeptide 0.001~2.0%, surplus are sterile water.Antibacterial peptide in the formula of the present invention can play the role of disinfection, and carrier hyaluronic acid can not only ensure the moistening of skin, can also improve the gas permeability of skin；Composition can be with broad-spectrum antiseptic, clean moisturizing, and formula is mild, non-stimulated, high stability, it contains a large amount of bioactie agents for being beneficial to skin regeneration technique, it can promote skin self-renewing, Regeneration and Repair, while coix seed polypeptide being coordinated to use, the antioxidant effect of striae of pregnancy repairing paste can be further increased, it slows down aging, and then the repairing effect of striae of pregnancy repairing paste can be greatly enhanced.
Description
Technical field
The present invention relates to a kind of striae of pregnancy repairing pastes of extract containing epidermal stem cells.
Background technology
Striae of pregnancy occurs from the item or band of the skin after skin excessively expansion and hormone variation, tiny can arrive
It is difficult to notice and can also form dolly dimple, skin is made to have the appearance of fold.Striae of pregnancy is too fast or unexpected due to skin
Drawing effect and generate, skin is mainly made in the growth of gestation weight and the bulge of abdomen due to women
Elastic fibers and collagenous fibres, by different degrees of damage or fracture, and then cause thinning of skin to attenuate due to external force pulls,
The support of elastic force and skin overcomes mistake, therefore generates pine across sense of sinking.
Though striae of pregnancy currently on the market, which repairs product, has certain effect, it is low that there is repair rates, and effect is not achieved
The requirement of patient, repairing effect are not ideal problems.Meanwhile existing striae of pregnancy repair cream, repairing paste etc. all contain
Chemical product has certain toxic side effect, and after long-term use, skin is susceptible to allergic reaction or inflammation, to skin
It injures larger.
Invention content
The technical problem to be solved by the present invention is to overcome the existing defects, provides a kind of the pregnant of the extract containing epidermal stem cells
It is pregnent line repairing paste.
The striae of pregnancy repairing paste of the extract containing epidermal stem cells, including each component of following weight proportion：
The key compound 0.005~5.0% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.1~5.0%, epidermis
Stem cell extract 0.5~9.0%, coix seed polypeptide 0.001~5.0%, 0.001~2.0wt% of palmitoyl oligopeptide, surplus are
Sterile water.
Further, the striae of pregnancy repairing paste for containing epidermal stem cells extract, includes each component of following weight proportion
's：
The key compound 0.4~0.6% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.4~0.8%, epidermal stem
Cell extract 3.0~7.0%, coix seed polypeptide 2.0~4.0%, palmitoyl oligopeptide 0.3~0.6%, surplus are sterile water.
Further, the antibacterial peptide in the key compound of the hyaluronic acid and antibacterial peptide is people source Cathelicidin peptides
LL-37 prepares the key compound of the two using following steps：
1), using solid-state chemical reaction method method, synthesis people source Cathelicidin peptide LL-37 crude products；People source
The amino acid sequence of Cathelicidin peptides LL-37 is LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES；
2), synthesis polypeptide crude product is used containing after acetonitrile solution dissolving, centrifugation retains supernatant, discards precipitation.Use reverse phase
High-efficient liquid phase chromatogram purification the people source Cathelicidin peptide LL-37 crude products make its purity be more than 95%；
3) antibacterial activity evaluation, is carried out to people source Cathelicidin peptides LL-37 after purification；
It tests LL-37 antibacterial peptides after purification respectively to test the activity and hemolytic of Grain-positive and gram-negative bacteria, packet
Include Escherichia coli and the multidrug resistance golden yellow staphylococcus of resistance to ampicillin and streptomysin；
4), in the neutral phosphate buffer liquid of pH 7.0~8.0, by mass concentration be 2% hyaluronic acid in 0.1M
Sodium metaperiodate oxidation under carry out aldehyde glycosylation reaction, formed aldehyde radical derivative, make hyaluronic acid have multiple aldehyde radicals；It is described
Hyaluronic acid molecular weight be 10~5000Kda；
5), in the neutral phosphate buffer liquid of pH 7.0~8.0, by the hyaluronic acid of aldehyde radical and people source after purification
Cathelicidin peptides LL-37 conjugation condensation reaction 4~6 hours, it is ensured that the front and back conjugation percentage difference of reaction is more than 10%；Make
Confirm reaction result with nuclear magnetic resonance.
Wherein, the conjugation percentage is the ratio of aldehyde radical quantity in the front and back polymer molecule of reaction.
Further, the antibacterial peptide in the key compound of the hyaluronic acid and antibacterial peptide is ox derived antimicrobial peptide
Indolicidin, base acid sequence are ILPWKWPWWPWRR-NH2, and the key compound of the two is prepared using following steps：
1), using solid-state chemical reaction method method, ox derived antimicrobial peptide Indolicidin crude products are synthesized；
2), using the high-efficient liquid phase chromatogram purification ox derived antimicrobial peptide Indolicidin, its purity is made to be more than 95%；
3) antibacterial activity evaluation, is carried out to ox derived antimicrobial peptide Indolicidin after purification；It is tested respectively to large intestine bar
The antibiotic property and hemolytic of bacterium and multidrug resistance golden yellow staphylococcus are tested
4), in the neutral phosphate buffer liquid of pH 7.0~8.0, by mass concentration be 2% hyaluronic acid in 0.1M
Sodium metaperiodate oxidation under carry out aldehyde glycosylation reaction；The molecular weight of the hyaluronic acid is 10~5000Kda；
5), in the neutral phosphate buffer liquid of pH 7.0~8.0, by the hyaluronic acid of aldehyde radical and Niu Yuan after purification
Antibacterial peptide Indolicidin conjugation condensation reaction 4~6 hours, it is ensured that conjugation percentage is more than 10%；
Wherein, the conjugation percentage is the ratio of aldehyde radical quantity in the front and back polymer molecule of reaction.
Further, a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, including following weight proportion are each
Component：
The key compound 0.5% of hyaluronic acid and ox derived antimicrobial peptide Indolicidin, polysorbate 0.65%, sodium chloride
4.1%, Tris-HCl 3.01%, EDTA 0.55%, surplus are sterile water.
Further, the striae of pregnancy repairing paste for containing epidermal stem cells extract, is calculated by mass percentage, containing following
Component：
The key compound 0.52% of hyaluronic acid and ox derived antimicrobial peptide Indolicidin, polysorbate 0.66%, sodium chloride
3.95%, Tris-HCl 3.2%, EDTA 0.50%, surplus are sterile water.
Hyaluronic acid is abundance, cheap natural polymer copolymer.Hyaluronic acid is with its unique molecule
Structure and physicochemical property show that a variety of important physiological functions, such as lubricating joint adjust the permeability of vascular wall in body,
Regulatory protein matter, Water-Electrolyte diffusion and operating, promote wound healing etc..Hyaluronic acid is to constitute human body cell interstitial, eye glass
The main component of the connective tissues such as glass body, knuckle synovia plays water conservation, maintains extracellular space, adjusts osmotic pressure, profit in vivo
Important physiological function that is sliding, promoting cell repair.Contain a large amount of carboxyl and hydroxyl in hyaluronan molecule, in aqueous solution shape
At intramolecular and intermolecular hydrogen bond, this makes it have powerful water retention, in combination with itself 400 times or more of water；Compared with
When high concentration, due to the complicated three-level reticular structure that its intermolecular interaction is formed, aqueous solution has significant viscoplasticity again.
Main component of the hyaluronic acid as intercellular matrix, directly participate in intraor extracellular electrolyte exchange regulation and control, play physics and
The filter of molecular information acts on.
Antibacterial peptide is a kind of biologically active micromolecule polypeptide generated through induction in organism, and molecular weight is 2000
~7000 or so, it is made of 20~60 amino acid residues.By antibacterial peptide source be divided into microbial antibacterial peptide, Antibacterial Peptide From Animals,
Antimicrobial Peptides From Plants；Antibacterial Peptide From Animals and humanized's antibacterial etc..Antibacterial peptide has obtained extensive research in wound repair field in recent years,
Document report people derived antimicrobial peptide (Host Defense Peptide) has broad-spectrum antiseptic, participates in wound inflammation and adjusts, promotees wound
Area's angiogenesis promotees the function of impingement epithelium regeneration.Antibacterial peptide will not cause to damage to the cell of normal mammalian, answer
With not will produce harmful effect in the process, but cancer cell line, bacterium and fractionated viral are shown significantly to kill and made
With, therefore there is more wide application prospect in antibacterial field.
The combination of polymers of the present invention can make multiple use, have a variety of applications, such as the disinfection, cleaning, leaching of skin
The nursing such as bubble, wetting, rewetting, rinsing, storage and eyes rinse, and at the same time, comfort are provided for the wearer of glasses
And acceptability.The present invention can also increase the compliance of user, can promote user's rule and consistent skin nursing
Custom, to be more advantageous to the holding of eye health.Any glasses, for example, traditional sclerderm skin, rigid gas permeable skin and
Flexible, hydrophilic or hydrogel skin, can be used the composition of the invention.
Beneficial effects of the present invention：
Inventive formulation contains a large amount of bioactie agents for being beneficial to skin regeneration technique, can promote skin self more
Newly, Regeneration and Repair, while coix seed polypeptide being coordinated to use, the antioxidant effect of striae of pregnancy repairing paste can be further increased, is delayed
Aging, and then the repairing effect of striae of pregnancy repairing paste can be greatly enhanced.Palmitoyl oligopeptide is coordinated to use simultaneously, it can further water
Change skin, Transdermal absorption, and then the repairing effect of striae of pregnancy repairing paste can be greatly enhanced.
Specific implementation mode
Hereinafter, preferred embodiments of the present invention will be described, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, is calculated by mass percentage, contains following components：
The key compound 0.005% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.1%, sodium chloride 9%, Job's tears
Benevolence polypeptide 0.001%, palmitoyl oligopeptide 0.001%, surplus are sterile water.
Embodiment 2
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, is calculated by mass percentage, contains following components：
The key compound 5.0% of hyaluronic acid and antibacterial peptide, nonionic surfactant 5.0%, epidermal stem cells extract
0.5%, coix seed polypeptide 2.5%, palmitoyl oligopeptide 2.0%, surplus is sterile water.
Embodiment 3
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, is calculated by mass percentage, contains following components：
The key compound 2.5% of hyaluronic acid and antibacterial peptide, nonionic surfactant 2.5%, epidermal stem cells extract
3.5%, coix seed polypeptide 5.0%, palmitoyl oligopeptide 1.0%, surplus is sterile water.
Embodiment 4
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, is calculated by mass percentage, contains following components：
The key compound 0.50% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.6%, epidermal stem cells extract
4.0%, coix seed polypeptide 3.0%, palmitoyl oligopeptide 0.55%, surplus is sterile water.
Embodiment 5
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, is calculated by mass percentage, contains following components：
The key compound 0.52% of hyaluronic acid and ox derived antimicrobial peptide Indolicidin, nonionic surfactant 0.66%,
Epidermal stem cells extract 3.95%, coix seed polypeptide 3.2%, palmitoyl oligopeptide 0.50%, surplus are sterile water.
Embodiment 6
A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells, is calculated by mass percentage, contains following components：
The key compound 0.5% of hyaluronic acid and people source Cathelicidin peptides LL-37, nonionic surfactant
0.65%, epidermal stem cells extract 4.1%, coix seed polypeptide 3.01%, palmitoyl oligopeptide 0.55%, surplus is sterile water.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (7)
1. a kind of striae of pregnancy repairing paste of extract containing epidermal stem cells, which is characterized in that be calculated by mass percentage, containing with
Lower component：
The key compound 0.005~5.0% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.1~5.0%, epidermal stem is thin
Born of the same parents' extract 0.5~9.0%, coix seed polypeptide 0.001~5.0%, palmitoyl oligopeptide 0.001~2.0%, surplus are sterile
Water.
2. a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells as described in claim 1, which is characterized in that including with
The each component of lower weight proportion：
The key compound 0.4~0.6% of hyaluronic acid and antibacterial peptide, nonionic surfactant 0.4~0.8%, epidermal stem cells
Extract 3.0~7.0%, coix seed polypeptide 2.0~4.0%, palmitoyl oligopeptide 0.3~0.6%, surplus are sterile water.
3. a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells as claimed in claim 1 or 2, which is characterized in that institute
The key compound of the hyaluronic acid and antibacterial peptide stated is prepared using following steps：
1), using solid-state chemical reaction method method, synthesis people source Cathelicidin peptide LL-37 crude products；
2), purify the people source Cathelicidin peptide LL-37 crude products with reversed-phase high performance liquid chromatography, its purity is made to be more than 95%；
3) antibacterial activity evaluation, is carried out to people source Cathelicidin peptides LL-37 after purification；
4), in the neutral phosphate buffer liquid of pH 7.0~8.0, by mass concentration be 2% hyaluronic acid 0.1M height
Under the oxidation of sodium iodate, aldehyde glycosylation reaction is carried out；
5), in the neutral phosphate buffer liquid of pH 7.0~8.0, by the hyaluronic acid of aldehyde radical and people source after purification
Cathelicidin peptides LL-37 conjugation condensation reaction 4~6 hours, it is ensured that the front and back difference of conjugation percentage reaction is more than 10%；
Wherein, the conjugation percentage is the difference of aldehyde radical quantity in the front and back polymer molecule of reaction.
4. a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells as claimed in claim 1 or 2, which is characterized in that institute
The key compound of the hyaluronic acid and antibacterial peptide stated is prepared using following steps：
1), using solid-state chemical reaction method method, ox derived antimicrobial peptide Indolicidin crude products are synthesized；
2), using the high-efficient liquid phase chromatogram purification ox derived antimicrobial peptide Indolicidin crude products, its purity is made to be more than 95%；
3) antibacterial activity evaluation, is carried out to ox derived antimicrobial peptide Indolicidin after purification；
4), in the neutral phosphate buffer liquid of pH 7.0~8.0, by mass concentration be 2% hyaluronic acid 0.1M height
Aldehyde glycosylation reaction is carried out under the oxidation of sodium iodate；
5), in the neutral phosphate buffer liquid of pH 7.0~8.0, by the hyaluronic acid of aldehyde radical and ox source antibacterial after purification
Peptide Indolicidin conjugation condensation reaction 4~6 hours, it is ensured that the front and back conjugation percentage difference of reaction is more than 10%；
Wherein, the conjugation percentage is the difference of aldehyde radical quantity in the front and back polymer molecule of reaction.
5. a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells as claimed in claim 1 or 2, which is characterized in that institute
The surfactant stated is one or more of glycerin monostearate, sucrose ester, polysorbate, aliphatic alcohol ester.
6. a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells as claimed in claim 1 or 2, which is characterized in that press
Mass percent calculates, and contains following components：
The key compound 0.5% of hyaluronic acid and people source Cathelicidin peptides LL-37, polysorbate 0.65%, sodium chloride
4.1%, phosphate buffer 3.01%, EDTA 0.55%, surplus is sterile water.
7. a kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells as described in claim 1, which is characterized in that press quality
Percentage calculation contains following components：
The key compound 0.52% of hyaluronic acid and ox derived antimicrobial peptide Indolicidin, polysorbate 0.66%, sodium chloride
3.95%, phosphate buffer 3.2%, EDTA 0.50%, surplus is sterile water.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810570015.XA CN108434080A (en) | 2018-06-05 | 2018-06-05 | A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810570015.XA CN108434080A (en) | 2018-06-05 | 2018-06-05 | A kind of striae of pregnancy repairing paste of the extract containing epidermal stem cells |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223677A (en) * | 2018-11-14 | 2019-01-18 | 科丽思化妆品（上海）有限公司 | A kind of Semen Coicis hydrolysate, preparation method and its application in cosmetics |
| CN110721117A (en) * | 2019-12-01 | 2020-01-24 | 广州一生美生物科技有限公司 | Freeze-dried powder preparation of beauty and skin care cosmetics and application of freeze-dried powder preparation in solution |
| FR3092493A1 (en) * | 2019-02-12 | 2020-08-14 | Dermaconcept Jmc | Cosmetic and / or dermatological composition to fight against stretch marks |
| CN112190533A (en) * | 2020-10-16 | 2021-01-08 | 潍坊卡多娜生物科技有限公司 | Stem cell striae gravidarum repair method |
| CN112316203A (en) * | 2020-11-06 | 2021-02-05 | 黄石瀚海新材料科技有限公司 | Cationic antibacterial peptide and hyaluronic acid composite hydrogel and preparation method thereof |
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| CN107753409A (en) * | 2017-12-06 | 2018-03-06 | 广州赛莱拉干细胞科技股份有限公司 | Striae gravidarum repair paste containing epidermal stem cell extract |
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| CN105616309A (en) * | 2014-10-28 | 2016-06-01 | 无锡灵锡医疗器械科技有限公司 | Preserving fluid of collagen mask |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109223677A (en) * | 2018-11-14 | 2019-01-18 | 科丽思化妆品（上海）有限公司 | A kind of Semen Coicis hydrolysate, preparation method and its application in cosmetics |
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| CN110721117A (en) * | 2019-12-01 | 2020-01-24 | 广州一生美生物科技有限公司 | Freeze-dried powder preparation of beauty and skin care cosmetics and application of freeze-dried powder preparation in solution |
| CN112190533A (en) * | 2020-10-16 | 2021-01-08 | 潍坊卡多娜生物科技有限公司 | Stem cell striae gravidarum repair method |
| CN112316203A (en) * | 2020-11-06 | 2021-02-05 | 黄石瀚海新材料科技有限公司 | Cationic antibacterial peptide and hyaluronic acid composite hydrogel and preparation method thereof |
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Application publication date: 20180824 |
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