CN114146012A - Antibacterial and anti-dandruff shampoo and preparation method thereof - Google Patents
Antibacterial and anti-dandruff shampoo and preparation method thereof Download PDFInfo
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- CN114146012A CN114146012A CN202110869760.6A CN202110869760A CN114146012A CN 114146012 A CN114146012 A CN 114146012A CN 202110869760 A CN202110869760 A CN 202110869760A CN 114146012 A CN114146012 A CN 114146012A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention provides an antibacterial and anti-dandruff shampoo which comprises the following components in percentage by weight: 0.1-0.5% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1-0.4% of disodium EDTA, 15-20% of sodium laureth sulfate, 1-5% of cocamidomethyl MEA, 1-4% of cocamidopropyl hydroxysulfobetaine, 71-3% of polyquaternary ammonium salt, 0.1-0.6% of avocado oil PEG-11 esters, 0.2-0.7% of sodium benzoate, 0.02-0.05% of citric acid, 0.05-0.15% of allantoin, 1-5% of hydrolyzed corn starch, 0.3-0.8% of preservative, 1-5% of conditioner and the balance of water. The invention can effectively sterilize through compounding of a plurality of components, has higher bacteriostatic rate to malassezia, simple preparation method, low cost and better public sensory experience, and is suitable for large-scale production.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to an antibacterial and anti-dandruff shampoo and a preparation method thereof.
Background
More and more people in modern society are troubled by dandruff, cutin accumulation can be caused when scalp metabolism is too fast or the cell maturation process is incomplete, the pityrosporum orbiculare with dead scalp cells and vitamins is propagated in large quantity to cause cutin peeling, and the dandruff is generated. The generation of dandruff is also associated with excessive bacterial growth and may cause head skin diseases such as infection of hair follicles. The dandruff is not only not beautiful and affects the personal image, but also causes the inflammation of hair follicles of head skin tissues, so that the antibacterial and dandruff-removing shampoo has wide market demand.
Disclosure of Invention
In order to solve the problems, the invention provides an antibacterial and anti-dandruff shampoo which comprises the following components in percentage by weight: 0.1-0.5% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1-0.4% of disodium EDTA, 15-20% of sodium laureth sulfate, 1-5% of cocamidomethyl MEA, 1-4% of cocamidopropyl hydroxysulfobetaine, 71-3% of polyquaternary ammonium salt, 0.1-0.6% of avocado oil PEG-11 esters, 0.2-0.7% of sodium benzoate, 0.02-0.05% of citric acid, 0.05-0.15% of allantoin, 1-5% of hydrolyzed corn starch, 0.3-0.8% of preservative, 1-5% of conditioner and the balance of water.
Preferably, the preservative is selected from one or more of phenoxyl alcohol compounds, aromatic alcohol and aromatic acid
Preferably, the preservative is phenoxyethanol, benzyl alcohol and benzoic acid.
Preferably, the preservative comprises 81-85% of benzyl alcohol, 14-16% of phenoxyethanol and 1-3% of benzoic acid in percentage by weight.
Preferably, the antibacterial and anti-dandruff shampoo further comprises 0.01-0.1 mass percent of hexamidine di (isethionic acid) salt.
Preferably, the weight ratio of the allantoin to the hexamidine di (isethionic acid) salt is 1-5: 1.
preferably, the weight ratio of the hexamidine di (isethionate) salt, sodium laureth sulfate and cocamidopropyl hydroxysultaine is (0.04-0.07): 17: 3.
preferably, the conditioning agent is selected from one or more of lactobacillus/soybean milk fermentation product filtrate and polyhydric alcohol.
Preferably, the conditioner comprises lactobacillus/soy milk fermentation product filtrate, butylene glycol and 1, 2-pentanediol.
Preferably, the antibacterial and anti-dandruff shampoo comprises the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.6% of preservative, 2% of conditioner and the balance of water.
The invention provides a preparation method of the antibacterial and anti-dandruff shampoo in a second aspect, and the preparation method comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring, adding EDTA disodium, and continuing stirring;
(2) adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating, stirring to dissolve completely, and cooling;
(3) adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, antiseptic, sodium benzoate and conditioner, and stirring;
(4) the pH was adjusted with citric acid and the viscosity was adjusted with cocamide methyl MEA.
Preferably, the step (4) adjusts the pH value to 5.0-6.0.
Compared with the prior art, the invention has the advantages and beneficial effects that:
(1) the invention provides an antibacterial and anti-dandruff shampoo which can effectively sterilize through compounding of multiple components, particularly has a high bacteriostatic rate on malassezia, and has a good anti-dandruff function. The hexamidine di (isethionic acid) salt added in the invention has synergistic effect with the preservative, and the bactericidal performance is improved.
(2) The invention provides a preparation method of an antibacterial and anti-dandruff shampoo, which is different from the adding sequence in the traditional preparation method, realizes good mutual solubility of components by gradually adding different components, and simultaneously enables the synergistic effect among the components to be exerted to the maximum extent. The preparation method is simple, good intersolubility can be realized without heating, and the preparation cost is reduced. Meanwhile, the color and the fragrance of the shampoo meet the requirements of the public, the public sensory experience is better, and the shampoo is suitable for large-scale production.
Detailed Description
The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definitions provided herein, the definition of the term provided herein controls.
The invention provides an antibacterial and anti-dandruff shampoo which comprises the following components in percentage by weight: 0.1-0.5% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1-0.4% of disodium EDTA, 15-20% of sodium laureth sulfate, 1-5% of cocamidomethyl MEA, 1-4% of cocamidopropyl hydroxysulfobetaine, 71-3% of polyquaternary ammonium salt, 0.1-0.6% of avocado oil PEG-11 esters, 0.2-0.7% of sodium benzoate, 0.02-0.05% of citric acid, 0.05-0.15% of allantoin, 1-5% of hydrolyzed corn starch, 0.3-0.8% of preservative, 1-5% of conditioner and the balance of water.
The EDTA disodium is ethylene diamine tetraacetic acid disodium; coconut oil acylCAS No of Aminomethyl MEA: 866889-75-0; the structural formula of the avocado oil PEG-11 esters is as follows:
in a preferred embodiment, the antibacterial and anti-dandruff shampoo further comprises 0.5-0.8% of essence.
In a preferred embodiment, the preservative is selected from one or more of phenoxyalcohols, aromatic alcohols, and aromatic acids.
In a preferred embodiment, the preservative is phenoxyethanol, benzyl alcohol and benzoic acid.
In a preferred embodiment, the preservative comprises 81-85% of benzyl alcohol, 14-16% of phenoxyethanol and 1-3% of benzoic acid by weight percentage.
The preservative is phenoxyethanol, benzyl alcohol and benzoic acid, so that the sterilization and anti-dandruff effects are improved.
In a preferred embodiment, the antibacterial and anti-dandruff shampoo further comprises 0.01-0.1 mass percent of hexamidine di (isethionic acid) salt.
In a preferred embodiment, the weight ratio of hexamidine di (isethionate) salt, sodium laureth sulfate, and cocamidopropyl hydroxysultaine is (0.04-0.07): 17: 3.
hexamidine di (isethionic acid) salt of formula C22H32N4O6S, has a spectrum antibacterial effect, the invention discovers that the proper weight ratio of hexamidine di (isethionic acid) salt, sodium laureth sulfate and cocamidopropyl hydroxysultaine can improve the bactericidal effect, and the inventor conjectures that the sodium laureth sulfate and cocamidopropyl hydroxysultaine improve the adsorption of the cationic property of the hexamidine di (isethionic acid) salt on hairHas the function of being more beneficial to the strengthening and the lasting exertion of the function of removing the dandruff.
In a preferred embodiment, the weight ratio of allantoin to hexamidine bis (isethionic acid) salt is from 1 to 5: 1.
allantoin is an amphoteric compound, including alcohol type and ketone type, and the inventor finds that the appropriate ratio of the allantoin to hexamidine di (hydroxyethyl sulfonate) salt is helpful for improving the sterilization and anti-dandruff efficacy of the shampoo. The inventors speculate that allantoin forms a conjugated system with hexamidine bis (isethionate) salt, which improves the stability of the composition and helps to improve the performance of the antimicrobial substance.
In a preferred embodiment, the conditioning agent is selected from one or more of lactobacillus/soy milk fermentation product filtrate, polyols.
In a preferred embodiment, the conditioning agent comprises lactobacillus/soy milk fermentation product filtrate, butanediol and 1, 2-pentanediol.
In a preferred embodiment, the antibacterial and anti-dandruff shampoo comprises the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.6% of preservative, 2% of conditioner and the balance of water.
The invention provides a preparation method of the antibacterial and anti-dandruff shampoo in a second aspect, and the preparation method comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring, adding EDTA disodium, and continuing stirring;
(2) adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating, stirring to dissolve completely, and cooling;
(3) adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, antiseptic, sodium benzoate and conditioner, and stirring;
(4) the pH was adjusted with citric acid and the viscosity was adjusted with cocamide methyl MEA.
In a preferred embodiment, the preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring, adding EDTA disodium, and continuing stirring;
(2) adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating, stirring to dissolve completely, and cooling;
(3) adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, antiseptic, sodium benzoate, conditioner and essence, and stirring;
(4) the pH was adjusted with citric acid and the viscosity was adjusted with cocamide methyl MEA.
In a preferred embodiment, the step (4) adjusts the pH to 5.0 to 6.0.
In a preferred embodiment, the viscosity of the step (4) is 4000 to 6000 mPa.S at 25 ℃.
In a preferred embodiment, the citric acid is 9-12% by mass of an aqueous citric acid solution.
The raw materials of the invention are purchased from the following manufacturers:
hexamidine di (isethionic acid) salt: middle lion
Hydroxypropyl guar hydroxypropyl trimonium chloride: solvay
Sodium laureth sulfate: lichen medicine
Cocoamide methyl MEA: zhongshan Kemei
Cocamidopropyl hydroxysultaine: flower language
Polyquaternium-7: lu bo run
Avocado oil PEG-11 esters: RES PHARMA
Allantoin: ningbo xiangshen (Ningbo flying god)
Hydrolyzing corn starch: lu bo run
Lactobacillus/soy milk fermentation product filtrate: xianting
Example 1
The embodiment provides an antibacterial and anti-dandruff shampoo which comprises the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.6% of preservative, 2% of conditioner and the balance of water. The preservative comprises 83 percent of benzyl alcohol, 15 percent of phenoxyethanol and 2 percent of benzoic acid by weight percentage. The conditioner comprises 40% of lactobacillus/soybean milk fermentation product filtrate, 30% of butanediol and 30% of 1, 2-pentanediol according to weight percentage.
The preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring for 3min to disperse, adding EDTA disodium, and stirring for 2 min.
(2) Adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating to 80 deg.C, stirring for 20min while maintaining the temperature until completely dissolved, and cooling.
(3) Cooling to 40 deg.C, adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, phenoxyethanol, benzyl alcohol, benzoic acid, sodium benzoate, essence, lactobacillus/soybean milk fermentation product filtrate, butanediol, and 1, 2-pentanediol, and stirring for 10 min.
(4) Adjusting pH to 5.5 with 10% citric acid aqueous solution, and adjusting viscosity to 5000 mPa.S with cocamide methyl MEA.
Example 2
The embodiment provides an antibacterial and anti-dandruff shampoo which comprises the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.8% of preservative, 2% of conditioner and the balance of water. The preservative comprises 83 percent of benzyl alcohol, 15 percent of phenoxyethanol and 2 percent of benzoic acid by weight percentage. The conditioner comprises 40% of lactobacillus/soybean milk fermentation product filtrate, 30% of butanediol and 30% of 1, 2-pentanediol according to weight percentage.
The preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring for 3min to disperse, adding EDTA disodium, and stirring for 2 min.
(2) Adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating to 80 deg.C, stirring for 20min while maintaining the temperature until completely dissolved, and cooling.
(3) Cooling to 40 deg.C, adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, phenoxyethanol, benzyl alcohol, benzoic acid, sodium benzoate, essence, lactobacillus/soybean milk fermentation product filtrate, butanediol, and 1, 2-pentanediol, and stirring for 10 min.
(4) Adjusting pH to 5.5 with 10% citric acid aqueous solution, and adjusting viscosity to 5000 mPa.S with cocamide methyl MEA.
Comparative example 1
The comparative example provides an antibacterial and anti-dandruff shampoo comprising the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamidomethyl MEA (methyl MEA), 3% of cocamidopropyl hydroxysulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.6% of preservative, 2% of conditioner and the balance of water. The preservative comprises 84% of benzyl alcohol, 15% of phenoxyethanol and 2% of benzoic acid in percentage by weight. The conditioner comprises 40% of lactobacillus/soybean milk fermentation product filtrate, 30% of butanediol and 30% of 1, 2-pentanediol according to weight percentage.
The preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring for 3min to disperse, adding EDTA disodium, and stirring for 2 min.
(2) Adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating to 80 deg.C, stirring for 20min while maintaining the temperature until completely dissolved, and cooling.
(3) Cooling to 40 deg.C, adding polyquaternium-7, avocado oil PEG-11 esters, hydrolyzed corn starch, phenoxyethanol, benzyl alcohol, benzoic acid, sodium benzoate, essence, lactobacillus/soybean milk fermentation product filtrate, butanediol, and 1, 2-pentanediol, and stirring for 10 min.
(4) Adjusting pH to 5.5 with 10% citric acid aqueous solution, and adjusting viscosity to 5000 mPa.S with cocamide methyl MEA.
Comparative example 2
The comparative example provides an antibacterial and anti-dandruff shampoo comprising the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.6% of preservative, 2% of conditioner and the balance of water. The preservative comprises 84% of benzyl alcohol, 15% of phenoxyethanol and 2% of benzoic acid in percentage by weight. The conditioner comprises 40% of lactobacillus/soybean milk fermentation product filtrate, 30% of butanediol and 30% of 1, 2-pentanediol according to weight percentage.
The preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring for 3min to disperse, adding EDTA disodium, and stirring for 2 min.
(2) Adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating to 80 deg.C, stirring for 20min while maintaining the temperature until completely dissolved, and cooling.
(3) Cooling to 40 deg.C, adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, phenoxyethanol, benzyl alcohol, benzoic acid, sodium benzoate, essence, lactobacillus/soybean milk fermentation product filtrate, butanediol, and 1, 2-pentanediol, and stirring for 10 min.
(4) Adjusting pH to 5.5 with 10% citric acid aqueous solution, and adjusting viscosity to 5000 mPa.S with cocamide methyl MEA.
Comparative example 3
The comparative example provides an antibacterial and anti-dandruff shampoo comprising the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.2% of preservative, 2% of conditioner and the balance of water. The preservative comprises 84% of benzyl alcohol, 15% of phenoxyethanol and 2% of benzoic acid in percentage by weight. The conditioner comprises 40% of lactobacillus/soybean milk fermentation product filtrate, 30% of butanediol and 30% of 1, 2-pentanediol according to weight percentage.
The preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring for 3min to disperse, adding EDTA disodium, and stirring for 2 min.
(2) Adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating to 80 deg.C, stirring for 20min while maintaining the temperature until completely dissolved, and cooling.
(3) Cooling to 40 deg.C, adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, phenoxyethanol, benzyl alcohol, benzoic acid, sodium benzoate, essence, lactobacillus/soybean milk fermentation product filtrate, butanediol, and 1, 2-pentanediol, and stirring for 10 min.
(4) Adjusting pH to 5.5 with 10% citric acid aqueous solution, and adjusting viscosity to 5000 mPa.S with cocamide methyl MEA.
Comparative example 4
The embodiment provides an antibacterial and anti-dandruff shampoo which comprises the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonic acid) salt, 0.6% of preservative, 2% of conditioner and the balance of water. The preservative comprises 84% of benzyl alcohol, 15% of phenoxyethanol and 2% of benzoic acid in percentage by weight. The conditioner comprises 40% of lactobacillus/soybean milk fermentation product filtrate, 30% of butanediol and 30% of 1, 2-pentanediol according to weight percentage.
The preparation method of the antibacterial and anti-dandruff shampoo comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring for 3min to disperse, adding EDTA disodium, and stirring for 2 min.
(2) Adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating to 80 deg.C, stirring for 20min while maintaining the temperature until completely dissolved, and cooling.
(3) Cooling to 40 deg.C, adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, phenoxyethanol, benzyl alcohol, benzoic acid, sodium benzoate, essence, lactobacillus/soybean milk fermentation product filtrate, butanediol, and 1, 2-pentanediol, and stirring for 10 min.
(4) Adjusting pH to 6.5 with 10% citric acid aqueous solution, and adjusting viscosity to 5000 mPa.S with cocamide methyl MEA.
Performance testing
1. Malassezia bacteriostasis test-measuring diameter of bacteriostasis zone
The test method comprises the following steps:
and (3) measuring the diameter of the inhibition zone of the antibacterial and anti-dandruff shampoo on malassezia by adopting a filter paper diffusion method. 100 μ L of overnight-cultured bacterial suspension (1X 10)7CFU/mL) was spread on a culture medium, and sterilized filter paper sheets having a diameter of 6mm were soaked with the antibacterial and antidandruff shampoos of examples and comparative examples, which were diluted 20 times, respectively, and the filter paper sheets were placed on the culture medium, and the culture medium was cultured in an incubator at 37 ℃ for 24 hours, and the diameter of the zone of inhibition was measured with a vernier caliper. The experiment was repeated 3 times and the average was taken. The test results are shown in table 1.
TABLE 1 Malassezia bacteriostasis zone test results
2. The example and comparative shampoos were tested for stability and the results are shown in table 2.
TABLE 2 stability test results
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. An antibacterial and anti-dandruff shampoo is characterized in that: the paint comprises the following components in percentage by weight: 0.1-0.5% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1-0.4% of disodium EDTA, 15-20% of sodium laureth sulfate, 1-5% of cocamidomethyl MEA, 1-4% of cocamidopropyl hydroxysulfobetaine, 71-3% of polyquaternary ammonium salt, 0.1-0.6% of avocado oil PEG-11 esters, 0.2-0.7% of sodium benzoate, 0.02-0.05% of citric acid, 0.05-0.15% of allantoin, 1-5% of hydrolyzed corn starch, 0.3-0.8% of preservative, 1-5% of conditioner and the balance of water.
2. The antibacterial and anti-dandruff shampoo as claimed in claim 1, wherein: the preservative is selected from one or more of phenoxyl alcohol compounds, aromatic alcohol and aromatic acid.
3. The antibacterial and anti-dandruff shampoo as claimed in claim 2, wherein: the preservative comprises 81-85% of benzyl alcohol, 14-16% of phenoxyethanol and 1-3% of benzoic acid in percentage by weight.
4. The antibacterial and anti-dandruff shampoo as claimed in claim 1, wherein: the antibacterial and anti-dandruff shampoo further comprises 0.01-0.1 mass percent of hexamidine di (isethionic acid) salt.
5. The antibacterial and anti-dandruff shampoo according to claim 4, wherein: the weight ratio of the allantoin to the hexamidine di (isethionic acid) salt is 1-5: 1.
6. the antibacterial and anti-dandruff shampoo according to claim 4, wherein: the weight ratio of hexamidine di (isethionate) salt, sodium laureth sulfate and cocamidopropyl hydroxysultaine is (0.04-0.07): 17: 3.
7. the antibacterial and anti-dandruff shampoo as claimed in claim 1, wherein: the conditioning agent is selected from one or more of lactobacillus/soybean milk fermentation product filtrate and polyalcohol.
8. The antibacterial and anti-dandruff shampoo as claimed in claim 1, wherein: the paint comprises the following components in percentage by weight: 0.2% of hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 17% of sodium laureth sulfate, 1.5% of cocamide methyl MEA, 3% of cocamide propyl hydroxy sulfobetaine, 71.5% of polyquaternary ammonium salt, 0.5% of avocado oil PEG-11 esters, 0.4% of sodium benzoate, 0.6% of essence, 0.03% of citric acid, 0.1% of allantoin, 3% of hydrolyzed corn starch, 0.05% of hexamidine di (hydroxyethyl sulfonate), 0.6% of preservative, 2% of conditioner and the balance of water.
9. A method for preparing the antibacterial and anti-dandruff shampoo as defined in claim 1, wherein the method comprises the following steps: the method comprises the following steps:
(1) adding water and hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, stirring, adding EDTA disodium, and continuing stirring;
(2) adding sodium laureth sulfate, cocamidopropyl hydroxysultaine, and allantoin, heating, stirring to dissolve completely, and cooling;
(3) adding hexamidine di (hydroxyethyl sulfonate) salt, polyquaternary ammonium salt-7, avocado oil PEG-11 esters, hydrolyzed corn starch, antiseptic, sodium benzoate and conditioner, and stirring;
(4) the pH was adjusted with citric acid and the viscosity was adjusted with cocamide methyl MEA.
10. The method for preparing the antibacterial and anti-dandruff shampoo as claimed in claim 9, wherein the method comprises the following steps: and (4) adjusting the pH value to 5.0-6.0.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114712279A (en) * | 2022-04-01 | 2022-07-08 | 广州帝臣生物科技股份有限公司 | Deoiling shampoo |
| CN115487127A (en) * | 2022-07-13 | 2022-12-20 | 广东嘉丹婷日用品有限公司 | Anti-hair loss oil-control silicone-oil-free shampoo and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107296771A (en) * | 2017-07-31 | 2017-10-27 | 曾万祥 | A kind of desquamation compositions and extra quality multiple-effect are without silicone oil shampoo |
| CN107349122A (en) * | 2017-06-15 | 2017-11-17 | 曾万祥 | A kind of desquamation compositions and its application |
| CN109846729A (en) * | 2019-04-10 | 2019-06-07 | 浙江养丝生物科技有限公司 | A kind of scalp cleaning condensation and its preparation process |
| CN111514088A (en) * | 2020-03-25 | 2020-08-11 | 广州黛莱美化妆品有限公司 | Shampoo and preparation method thereof |
| CN112754985A (en) * | 2021-01-04 | 2021-05-07 | 珠海伊斯佳科技股份有限公司 | Composition containing bacillus fermentation product and shampoo containing composition |
-
2021
- 2021-07-30 CN CN202110869760.6A patent/CN114146012A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349122A (en) * | 2017-06-15 | 2017-11-17 | 曾万祥 | A kind of desquamation compositions and its application |
| CN107296771A (en) * | 2017-07-31 | 2017-10-27 | 曾万祥 | A kind of desquamation compositions and extra quality multiple-effect are without silicone oil shampoo |
| CN109846729A (en) * | 2019-04-10 | 2019-06-07 | 浙江养丝生物科技有限公司 | A kind of scalp cleaning condensation and its preparation process |
| CN111514088A (en) * | 2020-03-25 | 2020-08-11 | 广州黛莱美化妆品有限公司 | Shampoo and preparation method thereof |
| CN112754985A (en) * | 2021-01-04 | 2021-05-07 | 珠海伊斯佳科技股份有限公司 | Composition containing bacillus fermentation product and shampoo containing composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114712279A (en) * | 2022-04-01 | 2022-07-08 | 广州帝臣生物科技股份有限公司 | Deoiling shampoo |
| CN115487127A (en) * | 2022-07-13 | 2022-12-20 | 广东嘉丹婷日用品有限公司 | Anti-hair loss oil-control silicone-oil-free shampoo and preparation method thereof |
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