CN111346124A - Formula and preparation method of skin disinfection cleaning solution - Google Patents
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Abstract
The invention discloses a formula of a skin disinfection cleaning solution and a preparation method thereof, wherein the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride; according to the invention, the cetylpyridinium chloride and the benzalkonium chloride are compounded for use, so that the speed and the effect of killing bacteria and fungi are improved; the honeysuckle extract can be used for preventing novel coronavirus in daily life, and is safe and non-irritant to skin mucosa.
Description
Technical Field
The invention relates to the field of washing and chemical cleaning, in particular to a formula of a skin disinfection cleaning solution and a preparation method thereof.
Background
The washing-free skin disinfection cleaning solution in the market takes iodine tincture, ethanol, triclosan, parachlorometaxylenol and the like as disinfectants; and then using polyalcohol, amino acids, water-soluble short-carbon-chain glyceride and the like as a humectant, but because of the selection of the disinfectant, the damage to the skin can not be reduced even by adding squalane and lanolin; the market needs a cleaning solution which can effectively kill viruses, bacteria and fungi and is safe and nonirritating to skin mucous membrane, and the invention solves the problems.
Disclosure of Invention
In order to solve the defects of the prior art, the invention aims to provide a formula of a skin disinfection cleaning solution and a preparation method thereof, wherein cetylpyridinium chloride (CPC) and benzalkonium chloride are compounded for use, so that the speed and the effect of killing bacteria and fungi are improved; the honeysuckle extract can be used for preventing novel coronavirus in daily life, and is safe and non-irritant to skin mucosa.
In order to achieve the above object, the present invention adopts the following technical solutions:
the formula of the skin disinfection cleaning solution comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride.
The formula of the skin disinfection cleaning solution comprises the following components: 84.7 parts of purified water, 7.5 parts of glycerol, 5 parts of butanediol, 0.8 part of 1, 2-hexanediol, 1.2 parts of honeysuckle extract and 0.8 part of sterilizing agent.
The sterilizing agent comprises the following components in percentage by mass: 50% phenoxyethanol, 25% benzalkonium chloride and 25% cetylpyridinium chloride.
In the formula of the skin disinfection cleaning solution, the effective component of the honeysuckle extract is chlorogenic acid, and the proportion of the effective component is more than or equal to 70%.
The formula of the skin disinfection cleaning solution comprises the following components in parts by weight: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract, 0.4-1.1 parts of sterilizing agent and 0.2-0.4 part of daily chemical essence.
A method for preparing a skin disinfection cleaning solution comprises the following steps;
step one, preparing materials according to a formula;
the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride;
adding purified water into a stirring pot, adding glycerol, butanediol and 1, 2-hexanediol, stirring for 8-20 minutes, and uniformly mixing to obtain a first mixture;
step three, adding the honeysuckle extract into the first mixture, and stirring for 15-20 minutes until the mixture is uniformly mixed to obtain a second mixture;
adding phenoxyethanol, benzalkonium chloride and cetylpyridinium chloride into the purified water, uniformly mixing to obtain a sterilization mixed solution, adding the sterilization mixed solution into the second mixture, and stirring for 6-10 minutes until the sterilization mixed solution is uniformly mixed to obtain a third mixture;
and step five, adding a pH regulator into the third mixture to keep the pH of the mixed solution between 6.0 and 7.0, and stirring for 6 to 10 minutes until the mixed solution is uniformly mixed to obtain the skin cleaning solution.
The preparation method of the skin disinfection cleaning solution comprises the following steps;
step one, preparing materials according to a formula;
the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride, 20-40% of cetylpyridinium chloride and 0.2-0.4 part of daily chemical essence;
adding purified water into a stirring pot, adding glycerol, butanediol, 1,2 hexanediol and daily chemical essence, stirring for 8-20 minutes, and uniformly mixing to obtain a first mixture;
step three, adding the honeysuckle extract into the first mixture, and stirring for 15-20 minutes until the mixture is uniformly mixed to obtain a second mixture;
adding phenoxyethanol, benzalkonium chloride and cetylpyridinium chloride into the purified water, uniformly mixing to obtain a sterilization mixed solution, adding the sterilization mixed solution into the second mixture, and stirring for 6-10 minutes until the sterilization mixed solution is uniformly mixed to obtain a third mixture;
and step five, adding a pH regulator into the third mixture to keep the pH of the mixed solution between 6.0 and 7.0, and stirring for 6 to 10 minutes until the mixed solution is uniformly mixed to obtain the skin cleaning solution.
In the preparation method of the skin disinfection cleaning solution, the pH regulator is citric acid.
The invention has the advantages that:
the cetylpyridinium chloride is a quaternary ammonium salt substance, can reduce the surface tension of water due to being a cationic surfactant, has the characteristics of low wettability and air bubble property, and can kill bacteria and fungi; benzalkonium chloride can quickly inhibit leaching type and resident type bacteria and fungi, is safe and non-irritant to skin mucosa, and is safe and stable; the two are compounded to quickly kill 99.9 percent of bacteria on the surface of the skin; the speed and the effect of killing bacteria and fungi are improved;
the novel coronavirus can be prevented in daily life by matching with the honeysuckle extract;
the disinfectant is selected and matched with the humectant, and the product is safe and non-irritant to skin mucous membranes, is high in stability, can be directly sprayed on hands, does not generate skin conditions such as chapping and the like, does not need to be additionally added with oily skin care ingredients, and reduces the cost.
Detailed Description
The following specific examples are intended to illustrate the invention.
A method for preparing a skin disinfection cleaning solution comprises the following steps;
step one, preparing materials according to a formula;
the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride;
the composite material comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract, 0.4-1.1 parts of sterilizing agent and 0.2-0.4 part of daily chemical essence; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride.
The effective component of the honeysuckle extract is chlorogenic acid, and the proportion of the effective component is more than or equal to 70%.
Adding purified water into a stirring pot, adding glycerol, butanediol and 1, 2-hexanediol, stirring for 8-20 minutes, and uniformly mixing to obtain a first mixture;
if the daily chemical essence is added, the step two is as follows:
adding purified water into a stirring pot, adding glycerol, butanediol, 1,2 hexanediol and daily chemical essence, stirring for 8-20 minutes, and uniformly mixing to obtain a first mixture;
step three, adding the honeysuckle extract into the first mixture, and stirring for 15-20 minutes until the mixture is uniformly mixed to obtain a second mixture;
adding phenoxyethanol, benzalkonium chloride and cetylpyridinium chloride into the purified water, uniformly mixing to obtain a sterilization mixed solution, adding the sterilization mixed solution into the second mixture, and stirring for 6-10 minutes until the sterilization mixed solution is uniformly mixed to obtain a third mixture;
and step five, adding a pH regulator into the third mixture to keep the pH of the mixed solution between 6.0 and 7.0, and stirring for 6 to 10 minutes until the mixed solution is uniformly mixed to obtain the skin cleaning solution. Preferably, the pH regulator is citric acid, and any acidic pH regulator can be used for daily chemical products, such as: sorbic acid and tartaric acid.
Experiments prove that the sterilization effect can be improved by compounding the cetylpyridinium chloride and the benzalkonium chloride;
in the case of the example 1, the following examples are given,
the formula comprises the following components: 76.5g of purified water, 6.0g of glycerol, 4.0g of butanediol, 0.5g of 1, 2-hexanediol, 0.6g of honeysuckle extract and 0.4g of sterilizing agent; the sterilizing agent comprises: 50% phenoxyethanol, 25% benzalkonium chloride, 25% cetylpyridinium chloride;
in the case of the example 2, the following examples are given,
the formula comprises the following components: 84.7g of purified water, 7.5g of glycerol, 5g of butanediol, 0.8g of 1, 2-hexanediol, 1.2g of honeysuckle extract and 0.8g of sterilizing agent; the sterilizing agent comprises: 50% phenoxyethanol, 25% benzalkonium chloride, 25% cetylpyridinium chloride;
in the case of the example 3, the following examples are given,
the formula comprises the following components: 84.7g of purified water, 7.5g of glycerol, 5g of butanediol, 0.8g of 1, 2-hexanediol, 1.2g of honeysuckle extract and 0.8g of sterilizing agent; the sterilizing agent comprises: 50% phenoxyethanol, 25% benzalkonium chloride, 25% cetylpyridinium chloride;
in the comparative example 1, the following examples were conducted,
the formula comprises the following components: 84.7g of purified water, 7.5g of glycerol, 5g of butanediol, 0.8g of 1, 2-hexanediol, 1.2g of honeysuckle extract and 0.8g of sterilizing agent; the sterilizing agent comprises: 100% phenoxyethanol.
In the comparative example 2, the following examples were conducted,
the formula comprises the following components: 84.7g of purified water, 7.5g of glycerol, 5g of butanediol, 0.8g of 1, 2-hexanediol, 1.2g of honeysuckle extract and 0.8g of sterilizing agent; the sterilizing agent comprises: 50% of phenoxyethanol and 50% of benzalkonium chloride.
In the comparative example 3, the following examples were conducted,
the formula comprises the following components: 84.7g of purified water, 7.5g of glycerol, 5g of butanediol, 0.8g of 1, 2-hexanediol, 1.2g of honeysuckle extract and 0.8g of sterilizing agent; the sterilizing agent comprises: 50% phenoxyethanol and 50% xipyrazamine.
Preparing 5 groups of culture dishes, wherein each group comprises 10 culture dishes, the culture medium adopts a beef extract agar culture medium, and is respectively inoculated with staphylococcus aureus, escherichia coli and aspergillus, and cultured for one week at normal temperature; spraying the same amount of the five samples for sterilization, observing the number of bacterial plaques before and after spraying, and calculating the sterilization rate; the time at which the plaque number stabilized was recorded.
The experimental results are as follows:
and (4) analyzing results:
the products obtained by the formula in the range of the invention have better sterilization rate and quick sterilization time. The formulation of example 2 is the most preferred example, and the preferred formulation comprises: 84.7 parts of purified water, 7.5 parts of glycerol, 5 parts of butanediol, 0.8 part of 1, 2-hexanediol, 1.2 parts of honeysuckle extract and 0.8 part of sterilizing agent; the microbial inoculum comprises the following components in percentage by mass: 50% phenoxyethanol, 25% benzalkonium chloride and 25% cetylpyridinium chloride.
Experiment two:
the samples of examples 1 to 3 were subjected to a killing experiment according to the protocol "Disinfection technical Specification". The stock solution acts for 1 minute at the test temperature of 20 ℃, the measured killing log values of the stock solution to the escherichia coli are all greater than 5.00, and the sanitation requirement is met.
In the third experiment, the experiment was carried out,
and (4) testing the moisturizing effect:
the sample of example 2 was applied to 10 volunteers, and the skin moisture values 10 minutes before and 10 minutes after the application were measured using a skin moisture tester, and the index of each volunteer was increased by comparison of the values, and the average value of the increase was 4.
The hand drying-proof hand cream prepared by the formula product of the invention does not dry hands and has certain moisturizing effect.
The benzalkonium chloride and the cetylpyridinium chloride are compounded to quickly kill 99.9 percent of bacteria on the surface of the skin; the speed and the effect of killing bacteria and fungi are improved; the novel coronavirus can be prevented in daily life by matching with the honeysuckle extract; the disinfectant is selected and matched with the humectant, and the product is safe and non-irritant to skin mucous membranes, is high in stability, can be directly sprayed on hands, does not generate skin conditions such as chapping and the like, does not need to be additionally added with oily skin care ingredients, and reduces the cost.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.
Claims (8)
1. The formula of the skin disinfection cleaning solution is characterized by comprising the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride.
2. A skin sanitizing cleaning solution formulation according to claim 1 comprising: 84.7 parts of purified water, 7.5 parts of glycerol, 5 parts of butanediol, 0.8 part of 1, 2-hexanediol, 1.2 parts of honeysuckle extract and 0.8 part of sterilizing agent.
3. The formulation of a skin sanitizing cleaning solution according to claim 1, wherein said sterilizing agent comprises, in mass percent: 50% phenoxyethanol, 25% benzalkonium chloride and 25% cetylpyridinium chloride.
4. The formula of the skin disinfection cleaning solution as claimed in claim 1, wherein the effective component of the honeysuckle extract is chlorogenic acid, and the proportion of the effective component is more than or equal to 70%.
5. The formula of the skin disinfection cleaning solution according to claim 1, wherein the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract, 0.4-1.1 parts of sterilizing agent and 0.2-0.4 part of daily chemical essence.
6. A method for preparing a skin disinfection cleaning solution is characterized by comprising the following steps;
step one, preparing materials according to a formula;
the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride and 20-40% of cetylpyridinium chloride;
adding purified water into a stirring pot, adding glycerol, butanediol and 1,2 hexanediol, stirring for 8-20 minutes, and uniformly mixing to obtain a first mixture;
step three, adding the honeysuckle extract into the first mixture, and stirring for 15-20 minutes until the mixture is uniformly mixed to obtain a second mixture;
adding phenoxyethanol, benzalkonium chloride and cetylpyridinium chloride into the purified water, uniformly mixing to obtain a sterilization mixed solution, adding the sterilization mixed solution into the second mixture, and stirring for 6-10 minutes until the sterilization mixed solution is uniformly mixed to obtain a third mixture;
and step five, adding a pH regulator into the third mixture to keep the pH of the mixed solution between 6.0 and 7.0, and stirring for 6 to 10 minutes until the mixed solution is uniformly mixed to obtain the skin cleaning solution.
7. A method of preparing a skin sanitizing cleaning solution according to claim 5, comprising the steps of;
step one, preparing materials according to a formula;
the formula comprises the following components in parts by mass: 76.5-87.0 parts of purified water, 6.0-9.5 parts of glycerol, 4.0-6.0 parts of butanediol, 0.5-1.2 parts of 1, 2-hexanediol, 0.6-1.8 parts of honeysuckle extract and 0.4-1.1 parts of sterilizing agent; the sterilizing agent comprises the following components in percentage by mass: 30-60% of phenoxyethanol, 20-40% of benzalkonium chloride, 20-40% of cetylpyridinium chloride and 0.2-0.4 part of daily chemical essence;
adding purified water into a stirring pot, adding glycerol, butanediol, 1, 2-hexanediol and daily chemical essence, stirring for 8-20 minutes, and uniformly mixing to obtain a first mixture;
step three, adding the honeysuckle extract into the first mixture, and stirring for 15-20 minutes until the mixture is uniformly mixed to obtain a second mixture;
adding phenoxyethanol, benzalkonium chloride and cetylpyridinium chloride into the purified water, uniformly mixing to obtain a sterilization mixed solution, adding the sterilization mixed solution into the second mixture, and stirring for 6-10 minutes until the sterilization mixed solution is uniformly mixed to obtain a third mixture;
and step five, adding a pH regulator into the third mixture to keep the pH of the mixed solution between 6.0 and 7.0, and stirring for 6 to 10 minutes until the mixed solution is uniformly mixed to obtain the skin cleaning solution.
8. A skin sanitizing cleaning solution according to claim 6 or 7, wherein said pH adjusting agent is citric acid.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043701A (en) * | 2020-09-24 | 2020-12-08 | 上海中医药大学 | Medical application of long-chain quaternary ammonium salt compound |
| CN113068719A (en) * | 2021-03-31 | 2021-07-06 | 康柏利科技（苏州）有限公司 | Multifunctional disinfection and sterilization liquid and preparation method thereof |
| WO2022008088A1 (en) * | 2020-07-09 | 2022-01-13 | Symrise Ag | Compositions with virucidal and/or antiviral activity |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434042A (en) * | 2018-05-31 | 2018-08-24 | 武汉新大地环保材料股份有限公司 | A kind of novel daily use chemicals preservative and preparation method thereof |
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2020
- 2020-02-10 CN CN202010085304.8A patent/CN111346124A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434042A (en) * | 2018-05-31 | 2018-08-24 | 武汉新大地环保材料股份有限公司 | A kind of novel daily use chemicals preservative and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022008088A1 (en) * | 2020-07-09 | 2022-01-13 | Symrise Ag | Compositions with virucidal and/or antiviral activity |
| CN112043701A (en) * | 2020-09-24 | 2020-12-08 | 上海中医药大学 | Medical application of long-chain quaternary ammonium salt compound |
| CN113068719A (en) * | 2021-03-31 | 2021-07-06 | 康柏利科技（苏州）有限公司 | Multifunctional disinfection and sterilization liquid and preparation method thereof |
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Application publication date: 20200630 |