CN110522655A - A kind of active peptides milk matrix lipid body essence lotion and preparation method thereof with blue-opalescent and Tyndall effect - Google Patents
A kind of active peptides milk matrix lipid body essence lotion and preparation method thereof with blue-opalescent and Tyndall effect Download PDFInfo
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Abstract
The active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect that the present invention relates to a kind of, its constituent and parts by weight are as follows: 10-60 parts of milk matrix lipid body, 0.1-1 parts of active peptides .1-1 parts of ginsengenin 20,0.002-0.01 parts of yeast essence, α -0.001-0.01 parts of bisabolol, 1-3 parts of tea polyphenols, 0.01-1 parts of hyaluronic acid, 0.5-5 parts of trehalose, 0.01-3 parts of epsilon-polylysine, distilled water complements to 100 parts.This essence lotion is added using bisabolol and polylysine the joint preservative naturally extracted without chemistry for the first time, essence lotion has the effect of moisturizing, crease-resistant and whitening, it is quick permeation, good absorbing, full of nutrition, to solve the problems, such as that presently commercially available essence lotion is difficult to or is only capable of that a small amount of active delivery to skin base layer is played effect.
Description
Technical field
The invention belongs to cosmetic technical field, especially a kind of active peptides with blue-opalescent and Tyndall effect
Milk matrix lipid body essence lotion and preparation method thereof.
Background technique
Active peptides are a kind of water-solubility proteins being extracted from plants, have potent subduction skin melanin, desalinate and
The formation for preventing melanin, dramatically increases the insulation lock outlet capacity of skin, reduces the aged cells of skin surface, softening skin angle
Keratinocyte cells promote cell metabolism, accelerate the microcirculation of capillary, the white connection of the collagen band between enhancing cell
Power enables skin only white, soft, sparkling and crystal-clear, is the single-minded scavenger of oxygen radical generally acknowledged both at home and abroad full of elasticity.With anti-ageing
Old effect can directly be absorbed rapidly by human body, participate in adjusting metabolic processes, be essential in skin care cosmetics
Important source material.
Ginsenoside is the natural component extracted from ginseng, has potent subduction skin melanin, desalinates and prevent black
The formation of pigment dramatically increases skin water lock ability, and softening skin keratinocyte promotes cell metabolism, accelerates capillary
The microcirculation of blood vessel enhances the white attachment force of collagen band between cell, enables skin only white, soft, sparkling and crystal-clear, the function full of elasticity
Energy.
Yeast essence more do skin conditioning agent use, the various nutrition in ingredient natural amino acid rich at
Point, it is able to suppress tyrosinase activity, inhibits melanin, whitening, long-acting moisturizing and accelerated ageing cuticula thin to reach
The effect that born of the same parents are updated, and there is good safety and stability, it is usually used in cosmetics.
Skin is divided into epidermis and corium.Epidermis is the shallow structure of skin, is made of stratified squamous epithelium.From basal layer to
Surface can be divided into five layers, i.e. basal layer, spinous layer, stratum granulosum, hyaline layer and cuticula.Basal layer: it positioned at the bottommost layer of epidermis, borrows
Basement membrane is connected with the corium of deep layer.Basal layer is one layer of short columnar epithelial cell.Cell is smaller, marshalling, and core is in oval,
Often contain melanin granule in cytoplasm.There is melanocyte between short columnar epithelial cell.Melanocyte is slightly rounded, there is tree
Dendritic protrusion, karyon is smaller, can generate melanin granule.The cell division of basal layer is more active, constantly generates neoblast simultaneously
It is elapsed to shallow-layer, with the horn cell for supplementing aging, falling off.Therefore, also referred to as germinal layer.Common essence lotion is only capable of playing moist angle
The effect of matter layer, it is difficult to which active delivery to basal layer plays a role.
Nanotechnology is that cosmetics industry brings huge variation, and wherein liposomal particle size is in 50~200nm.Packet
The liposome for covering oil-soluble and water-soluble various active constituents and nutriment, since its structure composition is similar to biomembrane,
The imitated vesicle structure that phospholipid bilayer is formed has elasticity, may pass through skin and penetrates into deep layer, the effective component being wrapped by exists
Epidermis, intradermal deposit and form repository, act on skin base layer, outer in the cell directly, enduringly to play a role, from
And it realizes to the wetting of skin, wrinkle resistant, anti-aging, the various health and beauties such as remove freckle, anti-acne.Liposome is in dermatology
It being vigorously developed with the research in terms of cosmeceutical, the cosmetics containing liposome have the advantages that Traditional makeup is incomparable,
Its permeability, slow release, moisture retention, safety develop cosmetics to high quality, high-grade direction, and contain activity
Polypeptide, ginsenoside, yeast essence liposome, can directly carry active constituent and enter skin depths, it is thin to act on melanin
Born of the same parents have and reduce cutaneous pigmentation, the crease-resistant effect for removing fat granule.
Epsilon-polylysine is a kind of polypeptide with bacteriostasis efficacy, and this biological preservative is just applied to for the first time in the eighties
Food antiseptic.Epsilon-polylysine can be decomposed into lysine in human body, and lysine is one of 8 kinds of amino acid needed by human,
Therefore epsilon-polylysine is highly-safe in other chemical preservatives.Epsilon-polylysine is edible as a kind of food preservative,
As aseptic applications, its safety is higher than other kinds of preservative when the skin.Epsilon-polylysine antimicrobial spectrum is wide, for
The sharp candidiasis of saccharomyces, produces film pichia yeast, rose shadow yeast at method Rhodotorula sp；In gram-positive bacteria
Heat-resisting Bacillus stearothermophilus, bacillus coagulans, bacillus subtilis；Production moral bacillus in Gram-negative bacteria, large intestine bar
Bacterium etc. has apparent inhibition and killing effect.
With the progress of modern biotechnology and the development in market, former milk and dairy produce and its extract are more and more extensive
It applies in cosmetics on ground.Such as milk because of nutritional ingredient rich in and natural origin the features such as happiness by people seeking beauty
Love, good moisturizing, whitening and anti-aging, reparation and other effects can beautifying face and moistering lotion, apply in cosmetics, assign product it is various
Effect.Casein is mainly derived from the phosphoprotein of cow's milk, can be used as moisturizer, nutritional agents and conditioner and is added in cosmetics,
Play the role of increasing other active components simultaneously.Niacin rich in, ascorbic acid, orotic acid, vitamin A in milk.Its
In niacin is added in skin products can significantly mitigate some synthesis compounds to the excitement of skin, have promoting blood circulation and promote blood
The effect of circulation；Ascorbic acid has irreversible inhibiting effect to tyrosinase；Orotic acid is used in skin care item, not only nutritious
And opsonic action, cooperate with use that can prevent cutaneous pigmentation with vitamin A etc..The isolated lactoferrin pair from cow's milk
Peroxide radical has certain scavenging effect, can also assist in other substances and preferably plays a role；Newborn iron egg in milk
White is also good natural bacteriostatic agent, has broad-spectrum antibacterial effect, both inhibits the Gram-negative bacteria for needing iron, it is blue also to can inhibit leather
Family name's positive bacteria, it also has antibacterial antisepsis while playing skin-care effect in cosmetics.
α-bisabolol is to be present in one of yellow chamomile ingredient, and having reduces scytitis, antibacterial anti-irritant, work
The multiple biological activities such as blood and relieving pain, and have good stability and skin-friendliness, it is mainly used in skin sparing and skin
It nurses in cosmetics.
Tea polyphenols have the performances such as good inoxidizability, anti-aging, antibacterial, removing free radical, improvement peculiar smell.It is recognized
To be environmentally protective natural finished product, it is widely used in cosmetic field.
Trehalose is a kind of natural carbohydrate, has preferable compatibility, compatibility and stability, can almost add and take office
In what cosmetics.It is able to suppress fatty acid and the oxidative rancidity of esters in cosmetics, keeps various protein and polypeptide classes living
Property ingredient the effect of, also there is excellent water-retaining property and hygroscopicity, hyaluronic acid and trehalose use in conjunction, complementary synergy is simultaneous
Have biological preservation and intelligent moisture-keeping function, can remain " fresh " of tissue and skin and cosmetics itself.
Liposome is prepared using milk, soymilk or dairy produce as matrix, contains a variety of active ingredients, one side liposome itself is right
Have in skin and moisten trophism, on the other hand can carry active constituent and enter deep skin and play a role, quick permeation, suction
It keeps well, is full of nutrition, fundamentally improving facial skin situation, have a very important significance.
Active constituent only stays in keratoderma in existing essence aquatic products, it is difficult to enter basal layer cell, play anti-
Oxidation, whitening, the basic effect for improving skin condition can only play the effect of skin-moisturizing, skin in cuticula mostly.Active constituent
It is wasted mostly in default of good deep skin delivery system, ideal effect cannot be reached.
By retrieval, such as next chapter patent publication us relevant to present patent application is found:
A kind of complex polypeptide nano vesicle and its preparation method and application with skin repair function
(CN109875910A), the complex polypeptide nano vesicle, the component including following parts by weight: Regeneration and Repair active peptides 0.01
~1 part, 0.01~1 part of antioxidant activity polypeptide, 0.1~5 part of natural moisture preserving active factors, promotion microcirculation active constituent 0.01
~1 part, 5~20 parts of lipoid wall material, 0.1~5 part of cholesterine, 10~45 parts of polyalcohol and 30~98 parts of water.The present invention is directed to skin
Skin barrier difference repair mechanisms provide the reparation component for acting on different target spots, meanwhile, various parents are wrapped up using nano vesicle
Water, lipophilic active ingredient, and its unique closure lipid bilayer structure is utilized, the stability of remediation composition is significantly improved,
Promote skin permeation amount, effectively controls active constituent and be sustained and improve repairing effect.
By comparison, present patent application exists essential different from above-mentioned patent publication us.
Summary of the invention
Present invention aims to overcome that treating the shortcoming of the limitation of corneal injury mode in the prior art, one is provided
Kind has blue-opalescent and the active peptides milk matrix lipid body essence lotion of Tyndall effect and preparation method thereof, and the essence lotion is first
It is secondary to be added using the bisabolol that naturally extracts and polylysine joint preservative without chemistry, essence lotion have moisturizing, it is crease-resistant and
The effect of whitening, quick permeation, good absorbing, full of nutrition and liposome raw material are cheap and easy to get, industrialization easy to accomplish, to solve mesh
The expensive problem of preceding commercially available essence lotion.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect, constituent and
Parts by weight are as follows:
10-60 parts of milk matrix lipid body, 0.1-1 parts of active peptides .1-1 parts of ginsengenin 20, yeast essence 0.002-
0.01 part, α -0.001-0.01 parts of bisabolol, 1-3 parts of tea polyphenols, 0.01-1 parts of hyaluronic acid, 0.5-5 parts of trehalose, ε-is poly-
0.01-3 parts of lysine, distilled water complements to 100 parts.
Moreover, its constituent and parts by weight are as follows:
50 parts of milk matrix lipid body, 0.3 part of active peptides .2 parts of ginsengenin 20,0.01 part of yeast essence, α-opopanax
0.001 part of alcohol, 1 part of tea polyphenols, 0.1 part of hyaluronic acid, 1 part of trehalose, 0.6 part of epsilon-polylysine, distilled water complements to 100
Part.
Moreover, the milk matrix lipid body the preparation method comprises the following steps:
First by milk matrix in 32-36 DEG C incubation 5-10 minutes, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, homogeneous 2-8 minutes, pressure 1000-5000psi, milk matrix lipid body is made.
Moreover, the milk matrix is former one or more of milk or dairy produce.
Moreover, the original milk is milk, mare's milk, goat milk, soymilk, milk powder or Yoghourt.
Moreover, the active peptides the preparation method comprises the following steps:
Take walnut 10-25 parts by weight, walnut dregs 10-15 parts by weight, quinoa 10-30 parts by weight, buckwheat 10-25 parts by weight,
Brown rice 15-30 parts by weight crush, and adjust pH value to 8.5-9.0 after water is added, extract albumen with alkali extraction-acid precipitation and freeze dry
Dry, through protease hydrolyzed, 8000-10000rpm is centrifuged 5-10 minutes, and supernatant freeze-drying obtains active polypeptide extract.
Moreover, the effect of the epsilon-polylysine and bisabolol is collaboration antisepsis.
Moreover, the ginsenoside the preparation method is as follows:
Ginseng is taken, crushes, is added 10 times of volume ethanols, 80-85 DEG C of heating and refluxing extraction 2h, after being cooled to room temperature, vacuum
It filters；55-70 DEG C of filtrate heating is taken to vacuumize, rotary evaporation obtains concentrate, and it is dry that freezing is put into after -20 DEG C, -80 DEG C of pre-freezes
Dry machine is lyophilized with -80 DEG C, and ginsenoside dry powder is obtained after 12h.
Moreover, the milk matrix lipid body dilutes 10-100 times before mixing with other active components, with distilled water.
The preparation of active peptides milk matrix lipid body essence lotion as described above with blue-opalescent and Tyndall effect
Method, steps are as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and milk matrix lipid body are stirred
It is even, 32-36 DEG C incubation 5-10 minutes, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols are added, dissolves honeycomb film, homogeneous 2-8 minutes, pressure 1000-5000psi, is made and contains
The milk matrix lipid body of active constituent；
Aqueous solution is made finally, hyaluronic acid, epsilon-polylysine, trehalose are added in distilled water in proportion, takes this molten
Liquid is uniformly mixed with the milk matrix lipid body for containing active constituent to get the active peptides with blue-opalescent and Tyndall effect
Milk matrix lipid body essence lotion.
Moreover, active peptides, ginsenoside, α-bisabolol and yeast essence and milk matrix are uniformly mixed, 35
DEG C be incubated for 8 minutes.
Moreover, tea polyphenols aqueous solution is added, and dissolution honeycomb film, homogeneous 6 minutes, pressure 2500psi.
The advantages of present invention obtains and good effect are as follows:
1, essence lotion of the present invention contains milk matrix lipid body, can carry various active constituents and penetrate into skin base layer work
For the melanin granule in cell；Meanwhile the milk matrix lipid body prepared using former milk or dairy produce as raw material, its own also may be used
Using the nutritional ingredient and soothing effect in milk, the effect of playing skin-protecting face nursing.Essence lotion of the present invention has nano-carrier institute special
Some blue-opalescents and Tyndall effect, liposome structure stablize (as shown in Figure 7), for the first time using the bisabolol naturally extracted
Added with polylysine joint preservative without chemistry, essence lotion has the effect of moisturizing, crease-resistant and whitening, quick permeation, good absorbing,
Full of nutrition and liposome raw material is cheap and easy to get, industrialization easy to accomplish, with solve presently commercially available essence lotion be difficult to or be only capable of by
The problem of a small amount of active delivery to skin base layer plays effect.
2, the present invention using milk, soymilk or dairy produce as matrix prepares liposome, using natural phospholipid therein, cholesterol and
Structure is complicated for the liposome membrane of various polypeptide preparations, closer to the structure of biological cell film.Utilize this milk matrix rouge
Plastid contains a variety of active ingredients, and one side liposome itself, which has skin, moistens trophism, on the other hand can take
Band active constituent enters deep skin and plays a role, and more unexpectedly this liposome ratio with complicated membrane structure is common
The infiltration of liposome and assimilation effect are more preferable, can preferably merge with the basal layer cell containing melanin, from basic
Upper improvement facial skin situation, has a very important significance.In addition to this, the present invention no longer uses traditional organic anti-corrosive
Agent has and utilizes edible biological preservative epsilon-polylysine originally, and cooperation α-bisabolol plays Antimicrobial preservative
Effect.The present invention relates to liposome preparation use for the first time using milk matrix as raw material prepare.The present invention has nano-carrier
Macroscopic properties: blue-opalescent and Tyndall effect can be visually seen the presence of nano-carrier, there is no essence lotion that can have this at present
Appearance.
3, edible biological preservative epsilon-polylysine is utilized in essence lotion of the present invention, cooperation α-bisabolol plays anti-
The effect of bacterium corrosion-resistant, when only adding α-bisabolol or epsilon-polylysine, essence lotion still has different degrees of microbiological contamination phenomenon, will
The two is used in conjunction with, and has certain Synergistic antimicrobial ability, and the microbiological contamination phenomenon of essence lotion is significantly improved, and is added with commercially available
The control group essence lotion of machine preservative is suitable.And the additive amount of epsilon-polylysine be 0.6% when, the two fungistatic effect is best.
Detailed description of the invention
Fig. 1 is the grain size distribution that soymilk liposome measures three times in the present invention, and every curve represents one-shot measurement result；
Fig. 2 is the Zeta electric potential distribution map that soymilk liposome measures three times in the present invention, and every curve represents one-shot measurement
As a result；
Fig. 3 is the grain size distribution that milk liposome measures three times in the present invention, and every curve represents one-shot measurement result；
Fig. 4 is the Zeta electric potential distribution map that milk liposome measures three times in the present invention, and every curve represents one-shot measurement
As a result；
Fig. 5 is the Tyndall effect figure of laser irradiation milk liposome essence lotion of the present invention in the present invention；
Fig. 6 is the effect picture of essence lotion of the laser irradiation without liposome in the present invention；
Fig. 7 is the effect picture that milk liposome essence lotion has blue-opalescent in the present invention.
Specific embodiment
The embodiment of the present invention is described in detail below, it should be noted that the present embodiment is narrative, is not limited
, this does not limit the scope of protection of the present invention.
Raw material used in the present invention is unless otherwise specified conventional commercial product；Used in the present invention
Method is unless otherwise specified the conventional method of this field.
A kind of active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect, constituent and
Parts by weight are as follows:
10-60 parts of milk matrix lipid body, 0.1-1 parts of active peptides .1-1 parts of ginsengenin 20, yeast essence 0.002-
0.01 part, α -0.001-0.01 parts of bisabolol, 1-3 parts of tea polyphenols, 0.01-1 parts of hyaluronic acid, 0.5-5 parts of trehalose, ε-is poly-
0.01-3 parts of lysine, distilled water complements to 100 parts.
More preferably, constituent and parts by weight are as follows:
50 parts of milk matrix lipid body, 0.3 part of active peptides .2 parts of ginsengenin 20,0.01 part of yeast essence, α-opopanax
0.001 part of alcohol, 1 part of tea polyphenols, 0.1 part of hyaluronic acid, 1 part of trehalose, 0.6 part of epsilon-polylysine, distilled water complements to 100
Part.
More preferably, the milk matrix lipid body the preparation method comprises the following steps:
First by milk matrix in 32-36 DEG C incubation 5-10 minutes, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, homogeneous 2-8 minutes, pressure 1000-5000psi, milk matrix lipid body is made.
More preferably, the milk matrix is former one or more of milk or dairy produce.
More preferably, the former milk is milk, mare's milk, goat milk, soymilk, milk powder or Yoghourt.
More preferably, the active peptides the preparation method comprises the following steps:
Take walnut 10-25 parts by weight, walnut dregs 10-15 parts by weight, quinoa 10-30 parts by weight, buckwheat 10-25 parts by weight,
Brown rice 15-30 parts by weight crush, and adjust pH value to 8.5-9.0 after water is added, extract albumen with alkali extraction-acid precipitation and freeze dry
Dry, through protease hydrolyzed, 8000-10000rpm is centrifuged 5-10 minutes, and supernatant freeze-drying obtains active polypeptide extract.
More preferably, the effect of the epsilon-polylysine and bisabolol is collaboration antisepsis.
More preferably, the ginsenoside the preparation method is as follows:
Ginseng is taken, crushes, is added 10 times of volume ethanols, 80-85 DEG C of heating and refluxing extraction 2h, after being cooled to room temperature, vacuum
It filters；55-70 DEG C of filtrate heating is taken to vacuumize, rotary evaporation obtains concentrate, and it is dry that freezing is put into after -20 DEG C, -80 DEG C of pre-freezes
Dry machine is lyophilized with -80 DEG C, and ginsenoside dry powder is obtained after 12h.
More preferably, the milk matrix lipid body dilutes 10-100 times before mixing with other active components with distilled water.
The preparation of active peptides milk matrix lipid body essence lotion as described above with blue-opalescent and Tyndall effect
Method, steps are as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and milk matrix lipid body are stirred
It is even, 32-36 DEG C incubation 5-10 minutes, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols are added, dissolves honeycomb film, homogeneous 2-8 minutes, pressure 1000-5000psi, is made and contains
The milk matrix lipid body of active constituent；
Aqueous solution is made finally, hyaluronic acid, epsilon-polylysine, trehalose are added in distilled water in proportion, takes this molten
Liquid is uniformly mixed with the milk matrix lipid body for containing active constituent to get the active peptides with blue-opalescent and Tyndall effect
Milk matrix lipid body essence lotion.
More preferably, active peptides, ginsenoside, α-bisabolol and yeast essence and milk matrix are uniformly mixed,
35 DEG C are incubated for 8 minutes.
More preferably, addition tea polyphenols aqueous solution, dissolution honeycomb film, homogeneous 6 minutes, pressure 2500psi.
Embodiment 1
A kind of active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect, is by following weight
What the raw material and method of percentage obtained:
Raw material: soymilk liposome 50%, active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, α-is red does not have
Medicine alcohol 0.001%, tea polyphenols 1%, hyaluronic acid 0.1%, trehalose 1%, epsilon-polylysine 0.6%, distilled water surplus.
The preparation method is as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and soymilk liposome are stirred
Even, 35 DEG C are incubated for 8 minutes, lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols aqueous solution is added, dissolves honeycomb film, homogeneous 6 minutes, pressure 2500psi, is made and contains work
Property ingredient soymilk liposome, Fig. 1 and 2 be its particle diameter distribution and zeta potential profile, it is seen that measure liposomal particle size three times
It is evenly distributed, average grain diameter is about 140nm, and zeta current potential is about -30mV, and the system distribution of prompt is stablized；
Aqueous solution is made finally, hyaluronic acid, epsilon-polylysine, trehalose are added in distilled water in proportion, takes this molten
Liquid is uniformly mixed with the soymilk liposome for containing active constituent.
Embodiment 2
A kind of active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect, is by following weight
What the raw material and method of percentage obtained:
Raw material: milk liposome 50%, active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, α-is red does not have
Medicine alcohol 0.001%, tea polyphenols 1%, hyaluronic acid 0.1%, trehalose 1%, epsilon-polylysine 0.6%, distilled water surplus.
The preparation method is as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and milk liposome are stirred
Even, 35 DEG C are incubated for 8 minutes, lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols aqueous solution is added, dissolves honeycomb film, homogeneous 6 minutes, pressure 2500psi, is made and contains work
Property ingredient milk liposome, Fig. 3 and 4 be its particle diameter distribution and zeta potential profile, it is seen that measure liposomal particle size three times
It is evenly distributed, average grain diameter is about 120nm, and zeta current potential is about -30mV, and the system distribution of prompt is stablized；
Aqueous solution is made finally, hyaluronic acid, epsilon-polylysine, trehalose are added in distilled water in proportion, takes this molten
Liquid is uniformly mixed with the milk liposome for containing active constituent, and Fig. 5 is the Tyndall effect figure that laser irradiation is of the invention in darkroom,
It can be seen that neat and apparent laser via, Fig. 7 is the effect picture with blue-opalescent, is illustrated in essence lotion containing suspension and structure
Stable liposome, whole system are colloid, this is also macroscopic appearance specific to nano-carrier.
Embodiment 3
A kind of essence lotion is obtained by the raw material and method of following weight percent:
Raw material: active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, α-bisabolol 0.001%, tea
Polyphenol 1%, hyaluronic acid 0.1%, trehalose 1%, epsilon-polylysine 0.6%, distilled water surplus.
The preparation method is as follows:
By active peptides, ginsenoside, α-bisabolol, yeast essence, hyaluronic acid, epsilon-polylysine, trehalose, tea
Polyphenol, which is added in distilled water, is made aqueous solution, and Fig. 6 is the effect picture that laser irradiation is of the invention in darkroom, it is seen that without laser in solution
Access, only reflection of the glass bottle wall for light, no Tyndall effect.
Embodiment 4
A kind of essence lotion is obtained by the raw material and method of following weight percent:
Raw material: milk liposome 50%, active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, α-is red does not have
Medicine alcohol 0.001%, tea polyphenols 1%, hyaluronic acid 0.1%, trehalose 1%, epsilon-polylysine 0.6%, distilled water surplus.
The preparation method is as follows:
Firstly, milk liposome was made by milk homogeneous 6 minutes, pressure 2500psi of 20 times of dilution；
Then, in proportion by active peptides, ginsenoside, α-bisabolol, yeast essence, hyaluronic acid, the poly- bad ammonia of ε-
Acid, trehalose, tea polyphenols, which are added in distilled water, is made aqueous solution, and the solution is taken to mix with the milk liposome for containing active constituent
Uniformly.
Embodiment 5
A kind of essence lotion is obtained by the raw material and method of following weight percent:
Raw material: milk liposome 50%, active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, α-is red does not have
Medicine alcohol 0.001%, tea polyphenols 1%, hyaluronic acid 0.1%, trehalose 1%, distilled water surplus.
The preparation method is as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and milk liposome are stirred
Even, 35 DEG C are incubated for 8 minutes, lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols aqueous solution is added, dissolves honeycomb film, homogeneous 6 minutes, pressure 2500psi, is made and contains work
The milk liposome of property ingredient；
Aqueous solution is made finally, hyaluronic acid, trehalose are added in distilled water in proportion, takes the solution and contains activity
The milk liposome of ingredient is uniformly mixed.
Embodiment 6
A kind of active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect, is by following weight
What the raw material and method of percentage obtained:
Raw material: milk liposome 50%, active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, α-is red does not have
Medicine alcohol 0.001%, tea polyphenols 1%, hyaluronic acid 0.1%, trehalose 1%, epsilon-polylysine 0.3%, distilled water surplus.
The preparation method is as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and milk liposome are stirred
Even, 35 DEG C are incubated for 8 minutes, lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols aqueous solution is added, dissolves honeycomb film, homogeneous 6 minutes, pressure 2500psi, is made and contains work
The milk liposome of property ingredient；
Aqueous solution is made finally, hyaluronic acid, epsilon-polylysine, trehalose are added in distilled water in proportion, takes this molten
Liquid is uniformly mixed with the milk liposome for containing active constituent.
Embodiment 7
A kind of essence lotion is obtained by the raw material and method of following weight percent:
Raw material: milk liposome 50%, active peptides 0.3%, ginsengenin 20 .2%, yeast essence 0.01%, tea polyphenols
1%, hyaluronic acid 0.1%, trehalose 1%, epsilon-polylysine 0.6%, distilled water surplus.
The preparation method is as follows:
Firstly, active peptides, ginsenoside and yeast essence and milk liposome are uniformly mixed, 35 DEG C are incubated for 8
Minute, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols aqueous solution is added, dissolves honeycomb film, homogeneous 6 minutes, pressure 2500psi, is made and contains work
The milk liposome of property ingredient；
Aqueous solution is made finally, hyaluronic acid, epsilon-polylysine, trehalose are added in distilled water in proportion, takes this molten
Liquid is uniformly mixed with the milk liposome for containing active constituent.
Embodiment measure of merit:
Using embodiment 1-4 as experimental group 1-4, the common essence lotion in market is control group.Selection volunteer (25-55 years old, female
Property) 30 people, stochastic averagina is divided into 6 groups, experimental group and control group is coated in face after daily cleaning skin, and effect is observed after 30 days
Fruit.It is given a mark (0-100 points) to disparity items respectively according to change of skin, specific appraisal result (average value) is as follows:
1 appraisal result of table
By the experimental result of table 1 it is found that be added to liposome experimental group 1 and experimental group 2 in permeability, wrinkle, mention
Effect in terms of skin lightening color, reduction fat granule is better than being not added with the experimental group 3 of liposome and active constituent is not contained Entering fat matter
The experimental group 4 of body, it is seen that liposome carries the effect that active constituent enters deep skin performance.Moreover, experimental group 1 and experimental group
2 moisture retention is good, and oedema has obvious recession, and use is more comfortable.
The test of embodiment bacteriostasis:
With embodiment 2,5,6 and 7 for experimental group 2,5,6 and 7, the common essence lotion in market is control group.Each sterile preparation
20mL essence lotion opening room temperature is placed in air, and bacterium colony counts after the 0th, 10,15 day taking-up 3mL carries out Bacteria Culture.
2 different number of days bacterium colony count results of table
By the experimental result of table 2 it is found that essence lotion still has when only adding α-bisabolol or epsilon-polylysine in prescription
Different degrees of microbiological contamination phenomenon, the two is used in conjunction with, and may have certain Synergistic antimicrobial ability, and makes the microbiological contamination of essence lotion
Phenomenon significantly improves, suitable with the control group essence lotion of the commercially available organic preservative of addition.And the additive amount of epsilon-polylysine is
When 0.6%, the two fungistatic effect is best.
Although disclosing the embodiment of the present invention for the purpose of illustration, it will be appreciated by those skilled in the art that: not
Be detached from the present invention and spirit and scope of the appended claims in, various substitutions, changes and modifications be all it is possible, therefore, this
The range of invention is not limited to the embodiment and attached drawing disclosure of that.
Claims (10)
1. a kind of active peptides milk matrix lipid body essence lotion with blue-opalescent and Tyndall effect, it is characterised in that: its
Constituent and parts by weight are as follows:
10-60 parts of milk matrix lipid body, 0.1-1 parts of active peptides .1-1 parts of ginsengenin 20,0.002-0.01 parts of yeast essence,
α -0.001-0.01 parts of bisabolol, 1-3 parts of tea polyphenols, 0.01-1 parts of hyaluronic acid, 0.5-5 parts of trehalose, epsilon-polylysine
0.01-3 parts, distilled water complements to 100 parts.
2. the active peptides milk matrix lipid body essence according to claim 1 with blue-opalescent and Tyndall effect
Water, it is characterised in that: its constituent and parts by weight are as follows:
50 parts of milk matrix lipid body, 0.3 part of active peptides .2 parts of ginsengenin 20,0.01 part of yeast essence, α-bisabolol
0.001 part, 1 part of tea polyphenols, 0.1 part of hyaluronic acid, 1 part of trehalose, 0.6 part of epsilon-polylysine, distilled water complements to 100 parts.
3. the active peptides milk matrix lipid body essence according to claim 1 or 2 with blue-opalescent and Tyndall effect
Hua Shui, it is characterised in that: the milk matrix lipid body the preparation method comprises the following steps:
First by milk matrix in 32-36 DEG C incubation 5-10 minutes, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, homogeneous 2-8 minutes, pressure 1000-5000psi, milk matrix lipid body is made.
4. the active peptides milk matrix lipid body essence according to claim 3 with blue-opalescent and Tyndall effect
Water, it is characterised in that: the milk matrix is former one or more of milk or dairy produce.
5. the active peptides milk matrix lipid body essence according to claim 4 with blue-opalescent and Tyndall effect
Water, it is characterised in that: the original milk is milk, mare's milk, goat milk, soymilk, milk powder or Yoghourt.
6. the active peptides milk matrix lipid body essence according to claim 1 with blue-opalescent and Tyndall effect
Water, it is characterised in that: the active peptides the preparation method comprises the following steps:
Take walnut 10-25 parts by weight, walnut dregs 10-15 parts by weight, quinoa 10-30 parts by weight, buckwheat 10-25 parts by weight, brown rice
15-30 parts by weight crush, and adjust pH value to 8.5-9.0 after water is added, extract albumen with alkali extraction-acid precipitation and be freeze-dried, pass through
Protease hydrolyzed, 8000-10000rpm are centrifuged 5-10 minutes, and supernatant freeze-drying obtains active polypeptide extract.
7. the active peptides milk matrix lipid body essence according to claim 1 with blue-opalescent and Tyndall effect
Water, it is characterised in that: the effect of the epsilon-polylysine and bisabolol is collaboration antisepsis.
8. the active peptides milk matrix lipid body essence according to claim 1 with blue-opalescent and Tyndall effect
Water, it is characterised in that: the ginsenoside the preparation method is as follows:
Ginseng is taken, is crushed, 10 times of volume ethanols are added, 80-85 DEG C of heating and refluxing extraction 2h after being cooled to room temperature, is filtered by vacuum；
55-70 DEG C of filtrate heating is taken to vacuumize, rotary evaporation obtains concentrate, is put into freeze drier after -20 DEG C, -80 DEG C of pre-freezes
It is lyophilized with -80 DEG C, ginsenoside dry powder is obtained after 12h.
9. the active peptides milk matrix rouge according to any one of claims 1 to 8 with blue-opalescent and Tyndall effect
Plastid essence lotion, it is characterised in that: the milk matrix lipid body dilutes 10- before mixing with other active components, with distilled water
100 times.
10. the active peptides milk matrix lipid as described in any one of claim 1 to 9 with blue-opalescent and Tyndall effect
The preparation method of body essence lotion, it is characterised in that: steps are as follows:
Firstly, active peptides, ginsenoside, α-bisabolol and yeast essence and milk matrix lipid body are uniformly mixed,
32-36 DEG C incubation 5-10 minutes, it is lasting to stir；
Then, moisture is spin-dried for film dispersion method, at honeycomb film；
Then, tea polyphenols are added, dissolves honeycomb film, homogeneous 2-8 minutes, pressure 1000-5000psi, is made and contains activity
The milk matrix lipid body of ingredient；
Finally, in proportion will hyaluronic acid, epsilon-polylysine, trehalose be added distilled water in be made aqueous solution, take the solution with
The milk matrix lipid body for containing active constituent is uniformly mixed to get the active peptides milk base with blue-opalescent and Tyndall effect
Matter liposome essence lotion.
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