CN107296764A

CN107296764A - Cream and preparation method thereof

Info

Publication number: CN107296764A
Application number: CN201710509959.1A
Authority: CN
Inventors: 陈波
Original assignee: SHENZHEN YONGJITAI TECHNOLOGY Co Ltd
Current assignee: Guangzhou yuanshengyuan Cosmetics Co.,Ltd.
Priority date: 2017-06-28
Filing date: 2017-06-28
Publication date: 2017-10-27
Anticipated expiration: 2037-06-28
Also published as: CN107296764B

Abstract

The present invention relates to a kind of cream and preparation method thereof.According to mass fraction meter, preparing the raw material of cream includes：4 parts~32.5 parts of emollient, 2 parts~5 parts of butylmethoxydibenzoylmethane, 0.5 part~1 part of the propyl diphenol of dimethoxy-p base 4, 0.005 part~0.01 part of glabridin, 0.3 part~0.7 part of hydroxy decyl ubiquinone, 0.05 part~0.25 part of Sodium Hyaluronate, 1 part~5 parts of biological carbohydrate gum 1, 1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~1.5 parts of 3 O ethylascorbyl ethers, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 part~0.5 part of thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol.The cream is smaller to skin irritatin and with preferable whitening spot-removing and moistening effect.

Description

Cream and preparation method thereof

Technical field

The present invention relates to cosmetic field, more particularly to a kind of cream and preparation method thereof.

Background technology

With advancing age, life stress is increasing, and along with external environmental, ultraviolet is to facial skin Injury is increasing, causes melanin constantly to precipitate, skin becomes coarse, dark yellow and lacks moisture.At present, typically using cream The method that frost smears protection to carry out maintenance nursing to facial skin.

Cream is a kind of carrier of skin-care nutrient composition, and form is varied, there is oil-in-water type, water-in-oil type etc., wherein, Oil-in-water type is more suitable for the daily nursing of skin.Although also occurring in that the more whitening spot-removing to face and moisturizing have necessarily at present The cream of effect, but its whitening spot-removing effect and moistening effect still reach to the demand less than people, and the tool in these creams There is whitening effect to produce a certain degree of stimulation to the skin of some crowds, and cause allergic and red and swollen problem so that skin Skin becomes more fragile and sensitive.

The content of the invention

Based on this, it is necessary to provide cream a kind of smaller to skin irritatin and with preferable whitening spot-removing and moistening effect Frost.

In addition, also providing a kind of preparation method of cream.

A kind of cream, according to mass fraction meter, preparing the raw material of the cream includes：14 parts~32.5 parts of emollient, 2 Part~5 parts of butylmethoxydibenzoylmethane, 0.5 part~1 part of dimethoxy-p base -4- propyls diphenol, 0.005 part~0.01 part of glabridin, 0.3 part~0.7 part of hydroxy decyl ubiquinone, 0.05 part~0.25 part of hyaluronic acid Sodium, 1 part~5 parts of biological carbohydrate gum -1,1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~1.5 parts 3-O- ethylascorbyls ether, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 part~0.5 The thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol of part.

The emollient of above-mentioned cream plays a part of moisturizing moisturizing, and butylmethoxydibenzoylmethane is inhaled for ultraviolet Agent is received, with sun-proof effect, dimethoxy-p base -4- propyls diphenol, glabridin, niacinamide, 3-O- ethyls resist Bad hematic acid ether and peony root extractive are whitening composition, and hydroxy decyl ubiquinone, Sodium Hyaluronate, biological carbohydrate gum -1 and beta glucan are Moisturizing ingredient, dimethoxy-p base -4- propyls diphenol suppresses the formation of TYR enzyme and TRP-1 enzymes, glabridin energy Inside deep enough skin, and high activity can be kept in skin, the effect with whitening and high-efficiency antioxidant can effectively suppress The activity of a variety of enzymes in melanin generating process, particularly suppresses TYR enzyme activity；Niacinamide can speed up metabolism, The horn cell containing melanin is promoted to come off, because Skin Cell needs sufficient energy to complete daily physiological function, Niacinamide can also promote the horn cell containing melanin to come off by accelerating skin to update, and act on produced black Pigment, is shifted with reducing it to cells of superficial layer, promotes the synthesis of epidermis protein, improves skin quality；3-O- ethyls are anti-bad Hematic acid ether is a kind of water-soluble vitamin c derivative of oleophylic, and this not only makes it extremely convenient can be used in formula, more Plus make it penetrate readily through cuticula to enter skin corium, and enter after skin the effect for easily being decomposed and being played Vc by biology enzyme, from And its bioavilability is improved, and common vitamin C is difficult then to be absorbed by the skin, bioavilability is very low；3-O- ethyls resist Bad hematic acid ether can be by suppressing the Cu of tyrosinase²⁺Formation that is active and blocking melanin, and prevent sun-induced skin Inflammation, improves skin colour, promotes collagen to produce, and increases skin elasticity；Peony root extractive has excellent antiallergy Effect, calm condition susceptible, complete inhibition role of complement activity completely inhibits the release of histamine, can almost completely inhibited The effect of the sour enzyme of bright matter, has good inhibitory action to direct cutaneous contact dermatitis, suppresses to be pitched by arachidonic acid and angle Glycosides lures the oedema of hair, suppresses the formation of melanin, suppresses the generation of oxygen radical, and oil-control peroxidization eliminates fat Property of overflowing dermatitis.By being used together according to upper proportioning so that cream can not suppress the formation of TYR enzyme, suppress TYR enzyme Activity, reduce melanin formation, while improve and promote collagen generation, increase skin elasticity, improve skin support Antianaphylactic function, controls fat secretion, to reach lifting skin and muscles are fair the beautiful purpose of penetrating health.And hydroxy decyl ubiquinone is A kind of fat-soluble antioxidant, improves body moisture-retaining capacity, the nutrition of energy human activin cell and cellular energy, with raising people The functions such as body immunity, the anti-oxidant, anti-aging of enhancing and enhancing human activity, Sodium Hyaluronate can play the protection skin of uniqueness Skin is acted on, and skin moisturizing can be kept smooth, fine and smooth tender, high resilience, with wrinkle resistant, crease-resistant, beauty and health care and recovery skin The effect of physiological function；The performance of keeping humidity of biological carbohydrate gum -1 is superior, very strong with water binding ability, in the environment of low humidity Soaking effect is good, while forming ventilative sugared film in skin surface, prevents moisture of skin from evaporating once again；Biological carbohydrate gum -1 is simultaneously Acted on instant and long-acting replenishing water and preserving moisture, and because the polysaccharide (1Mda) of pbz polymer amount causes biological carbohydrate gum -1 to have Film forming, with good moistening effect, while the water absorbing capacity of polysaccharide, strengthens its moistening effect, meanwhile, biological carbohydrate gum -1 The generation of inflammation can be slowed down and reduction allergic reaction is reached；It possesses excellent senile-resistant efficacy to beta glucan, can smooth Fine wrinkles, improve skin elasticity, improve dermatoglyph degree, with unique straight-chain molecular structure, impart good transdermal Absorbent properties, promote fibroblast synthesis collagen, promote wound healing, repair impaired skin, give skin such as silk As moisten anti-oxidant, Green Tea Extract the effect of smooth sense of touch, i.e. hydroxy decyl ubiquinone, pore and space between cells can be got through, Moisturizing, nutritional ingredient is made to rapidly enter skin base layer, to reach the purpose for nourishing moisturizing, biological carbohydrate gum -1 can be on skin Sebum diaphragm is formed, to prevent the loss of human body moisture while the phenomenon that there is the function of antiallergic to reduce pachylosis, transparent Matter acid sodium strengthens moisturizing moisturizing, and beta glucan promotes fibroblast synthesis collagen, promotes wound healing, repairs impaired flesh Skin, gives skin and smooth sense of touch is moistened such as silk, and by improving the moisturizing of cream according to aforementioned proportion collective effect Moisturizing ability, and reduce stimulation of the external substance to skin, to reach perfect combination that product is used, so that above-mentioned butyl methoxy Base dibenzoyl methane and above-mentioned whitening composition (dimethoxy-p base -4- propyls diphenol, glabridin, niacinamide, 3-O- ethylascorbyls ether and peony root extractive) and moisturizing ingredient (hydroxy decyl ubiquinone, Sodium Hyaluronate, biological carbohydrate gum -1 And beta glucan) compound use is carried out by said ratio, stimulation of the ultraviolet radioactive to skin can be more efficiently reduced, is hindered The only formation of melanin, and skin is effectively protected, reach the effect that whitening spot-removing, moisturizing are repaired.And the experiment proved that, it is above-mentioned Cream hardly produces stimulation to skin.

In one of the embodiments, the emollient includes propane diols, olive oil, Nexbase 2004, Permethyl 99A, ring Five dimethyl silicone polymers, dimethyl silicone polymer, cetanol and stearyl alcohol.

In one of the embodiments, the mass fraction of the propane diols is 2 parts~4 parts, the mass parts of the olive oil Number is 2 parts~4 parts, and the mass fraction of the Nexbase 2004 is 2 parts~4 parts, the mass fraction of the Permethyl 99A for 3 parts~ 8 parts, the mass fraction of the ring five dimethyl silicone polymer is 2 parts~4 parts, and the mass fraction of the dimethyl silicone polymer is 0.5 part~1 part, the mass fraction of the cetanol is 0.5 part~2.0 parts, the mass fraction of the stearyl alcohol for 0.5 part~ 2.0 part.

In one of the embodiments, the thickener includes xanthans and hydroxyethyl cellulose.

In one of the embodiments, the emulsifying agent includes stereth -2 and stereth -21.

In one of the embodiments, it is 0.45 part~1.2 that the raw material for preparing the cream, which also includes mass fraction, The preservative of part.

A kind of preparation method of cream, comprises the following steps：

Raw material is provided, according to mass fraction meter, the raw material includes following component：14 parts~32.5 parts of emollient, 2 parts ~5 parts of butylmethoxydibenzoylmethane, 0.5 part~1 part of dimethoxy-p base -4- propyls diphenol, 0.005 part~0.01 part of glabridin, 0.3 part~0.7 part of hydroxy decyl ubiquinone, 0.05 part~0.25 part of hyaluronic acid Sodium, 1 part~5 parts of biological carbohydrate gum -1,1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~1.5 parts 3-O- ethylascorbyls ether, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 part~0.5 The thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol of part；

By the glabridin, the dimethoxy-p base -4- propyls diphenol, the niacinamide, the 3-O- Ethylascorbyl ether, the peony root extractive and the butanediol mixed dissolution, obtain the first mixture；

By the thickener, the Sodium Hyaluronate, the beta glucan, the dipotassium glycyrrhizinate, the emulsifying agent, institute State emollient and the butylmethoxydibenzoylmethane to mix at 75 DEG C~85 DEG C with deionized water, obtain second and mix Close liquid；And

Under conditions of 45 DEG C~50 DEG C, by second mixed liquor, first mixed liquor, the biological carbohydrate gum -1 and The hydroxy decyl ubiquinone mixing, obtains cream.

In one of the embodiments, the emollient includes propane diols, olive oil, Nexbase 2004, Permethyl 99A, ring Five dimethyl silicone polymers, dimethyl silicone polymer, cetanol and stearyl alcohol, and the mass fraction of the propane diols is 2 parts~4 Part, the mass fraction of the olive oil is 2 parts~4 parts, and the mass fraction of the Nexbase 2004 is 2 parts~4 parts, described different ten The mass fraction of dioxane is 3 parts~8 parts, and the mass fraction of the ring five dimethyl silicone polymer is 2 parts~4 parts, described poly- two The mass fraction of methylsiloxane is 0.5 part~1 part, and the mass fraction of the cetanol is 0.5 part~2.0 parts, the tristearin The mass fraction of alcohol is 0.5 part~2.0 parts；

Wherein, the preparation process of second mixed liquor is specially：By the deionized water, propane diols, described The sour sodium of bright matter, the beta glucan and the dipotassium glycyrrhizinate are mixed at 75 DEG C~85 DEG C, obtain the first premixed liquid；Will be described Emulsifying agent, the olive oil, the Nexbase 2004, the Permethyl 99A, the ring five dimethyl silicone polymer, described poly- two Methylsiloxane, the cetanol, the stearyl alcohol and the butylmethoxydibenzoylmethane are at 75 DEG C~85 DEG C Mixing, obtains the second premixed liquid；Under conditions of 75 DEG C~85 DEG C, second premixed liquid is mixed with first premixed liquid Close, obtain second mixed liquor.

In one of the embodiments, it is described specific the step of second premixed liquid is mixed with first premixed liquid For：Under continuous agitation, second premix is added in first premixed liquid, at 75 DEG C~85 DEG C Vacuum homogeneous 3 minutes~5 minutes, stops homogeneous 5 minutes~10 minutes, then homogeneous 3 minutes~5 minutes.

Brief description of the drawings

Fig. 1 is the flow chart of the preparation method of the cream of an embodiment.

Embodiment

For the ease of understanding the present invention, the present invention is described more fully below with reference to relevant drawings.In accompanying drawing Give the preferred embodiment of the present invention.But, the present invention can be realized in many different forms, however it is not limited to herein Described embodiment.On the contrary, the purpose for providing these embodiments is to make the understanding to the disclosure more saturating It is thorough comprehensive.

Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.

The cream of one embodiment, according to mass fraction meter, preparing the raw material of cream includes：14 parts~32.5 parts of moisturizing Agent, 2 parts~5 parts of butylmethoxydibenzoylmethane, 0.5 part~1 part of dimethoxy-p base -4- propyls two Phenol, 0.005 part~0.01 part of glabridin, 0.3 part~0.7 part of hydroxy decyl ubiquinone, 0.05 part~0.25 part of hyalomitome Sour sodium, 1 part~5 parts of biological carbohydrate gum -1,1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~1.5 parts 3-O- ethylascorbyls ether, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 part~ 0.5 part of thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol.

Wherein, emollient includes propane diols, olive oil, Nexbase 2004, Permethyl 99A, ring five dimethyl silicone polymer (this material derives from coconut oil, is unartificial synthesis compound), dimethyl silicone polymer, cetanol and stearyl alcohol.Wherein, third Glycol is water-soluble emollients；Nexbase 2004, Permethyl 99A are Synthetic Oil emollient；It is ring five dimethyl silicone polymer, poly- Dimethyl siloxane is inertia grease emollient；Cetanol and stearyl alcohol are natural solid grease emollient, and collective effect is in skin Skin surface, graceful soft skin sense and protective layer are provided for skin.

Specifically, the mass fraction of propane diols is 2 parts~4 parts, and the mass fraction of olive oil is 2 parts~4 parts, hydrogenates the poly- last of the ten Heavenly stems The mass fraction of alkene is 2 parts~4 parts, and the mass fraction of Permethyl 99A is 3 parts~8 parts, the quality of ring five dimethyl silicone polymer Number is 2 parts~4 parts, and the mass fraction of dimethyl silicone polymer is 0.5 part~1 part, the mass fraction of cetanol for 0.5 part~ 2.0 parts, the mass fraction of stearyl alcohol is 0.5 part~2.0 parts.

Wherein, butylmethoxydibenzoylmethane is maximally effective fat-soluble UVA filtering agents, is by U.S. FDA batch The safely effectively UVA sun-screening agents that quasi- sales counter is sold, it can be prevented with very effective blocking UVA so as to improve whitening Product whitening degree is shone, very effective protective effect and repair is played to human body skin.And butyl methoxy dibenzoyl base Methane and whitening composition (dimethoxy-p base -4- propyls diphenol, glabridin, niacinamide, 3-O- ethylascorbyls Ether and peony root extractive) compounding use can improve effect of whitening composition, wherein, butylmethoxydibenzoylmethane It is optimal with glabridin compounding effect.

Wherein, dimethoxy-p base -4- propyls diphenol, glabridin, hydroxy decyl ubiquinone, Sodium Hyaluronate, life Thing carbohydrate gum -1, beta glucan, niacinamide, 3-O- ethylascorbyls ether, dipotassium glycyrrhizinate, peony root extractive, para hydroxybenzene Ethyl ketone and 1,2- hexylene glycols are skin conditioning agent.

Wherein, dimethoxy-p base -4- propyls diphenol, glabridin, niacinamide, 3-O- ethylascorbyl ethers It is whitening composition with peony root extractive.

Specifically, dimethoxy-p base -4- propyls diphenol can effectively suppress the shape of TYR enzyme and TRP-1 enzymes Into obstruction activation point, so as to prevent the formation of melanin.

Glabridin can go deep into inside skin, and high activity can be kept in skin, with whitening and high-efficiency antioxidant Effect, can effectively suppress the activity of a variety of enzymes in melanin generating process, particularly suppress TYR enzyme activity.Meanwhile, Glabridin can also increase the stability of butylmethoxydibenzoylmethane.

The mechanism of action of niacinamide is：Niacinamide can activate the nucleotide phosphodiesterase of ring-type 3,5, and this enzyme can be by 3, the 5- cyclic adenosine monophosphates of stimulation melanin cytohormone are decomposed into adenine -5- monophosphates, so that the generation of melanin is reduced, And it has following effect：(1) accelerate metabolism, promote the horn cell containing melanin to come off, because Skin Cell needs Sufficient energy could complete daily physiological function, e.g., produce neoblast, synthesis collagen, produce fat and protein, conjunction Into DNA etc., and the reason such as aging often results in the decline of cellular activity energy, cause cell turnover speed to slow down, pigment it is excessive The aqueous degree of calm, skin is reduced, cutin is irregular etc..And the molecule of niacinamide is smaller, directly it can be absorbed by cell, and niacinamide energy Skin energy balance is kept, while cellular energy can be recovered, accelerates collagen synthesis, so that avoid skin because fat content is low, Melanin is excessively calm caused by cuticula is thinning.In addition, niacinamide can also promote to contain by accelerating skin to update The horn cell of melanin comes off；(2) melanin produced is acted on, is shifted with reducing it to cells of superficial layer；(3) promote Enter the synthesis of epidermis protein, improve skin quality.

3-O- ethylascorbyl ethers are also known as VCE, are a kind of highly useful vitamin C derivatives.3- O- ethylascorbyl ethers are a kind of water-soluble vitamin c derivatives of oleophylic, and this not only makes it can be extremely square in formula Just use, more makes it penetrate readily through after cuticula enters skin corium, and entrance skin and is easily decomposed and play by biology enzyme The effect of Vc, so that its bioavilability is improved, and common vitamin C is difficult then to be absorbed by the skin, bioavilability is very It is low.Moreover, the relatively common vitamin C of 3-O- ethylascorbyls ether also shows high stability.And 3-O- second Base ascorbic acid ether can be by suppressing the Cu of tyrosinase²⁺Activity, blocks the formation of melanin, and prevents sun-induced skin Skin inflammation, improves skin colour, promotes collagen to produce, and increases skin elasticity.

Peony root extractive has following effect：(1) excellent antiallergic effect, calm condition susceptible；(2) completely inhibit Role of complement activity；(3) release of histamine is completely inhibited；(4) effect of hyaluronidase can almost be completely inhibited；(5) it is right Direct cutaneous contact dermatitis has good inhibitory action；(6) oedema of hair is lured in suppression by arachidonic acid and carragenines； (7 suppress the formation of melanin；(8) generation of oxygen radical is suppressed；(9) oil-control peroxidization, eliminates seborrheica skin It is scorching；(10) lymphopoiesis, the lifting cellular immunity of division primary stimuli are suppressed.Wherein, peony root extractive can pass through city Face is commercially available, such as the Peony white peony root extractives of company are ground by upper Hisense.

Dipotassium glycyrrhizinate has the multiple efficacies such as antibacterial, anti-inflammatory, removing toxic substances, antiallergic, deodorization.

Wherein, hydroxy decyl ubiquinone, Sodium Hyaluronate, biological carbohydrate gum -1 and beta glucan are moisturizing ingredient.

Hydroxy decyl ubiquinone is a kind of water-soluble coenzyme Q10, the effect with significant anti-oxidant and anti-aging.One side Face, the deep enough cell of hydroxy decyl ubiquinone energy, strengthens consolidation binding ability, the opposing party between cell metabolism function, Polygonum Multiflorum Thunb Extract Face can epidermis shape glue elasticity network structure, repair wrinkle caused by fluid loss characteristics, and and then reach real moisturizing Effect.

Sodium Hyaluronate is referred to as preferable NMF in the world, is widely present in skin and other tissues Natural biological, with fabulous moisture-keeping function.The aqueous solution of Sodium Hyaluronate has high moisture retention, viscoplasticity and lubrication Property, it not only can moisten skin smooth, also with stronger wrinkle-chasing function, can increase skin elasticity, delay skin aging.

Biological carbohydrate gum -1 is the special poly in brown algae (for example, to bladder-wrack, yellow tang, the gloomy algae of love, sargassum thunbergii etc.) Sugar, is a kind of NMF of natural origin, and it is very strong with reference to outlet capacity, is also shown in the environment of low humidity good Soaking effect, and ventilative sugared film is formed in skin surface, prevent moisture of skin from evaporating once again, strengthen its moistening effect.It is biological Carbohydrate gum -1 can promote inertia macrophage from being contaminted a little by competitively suppressing M.I.F (macrophage migration inhibition factor) Remove, oneself can be fixed on the fucose on the acceptor of macrophage or contained by biological carbohydrate gum -1 by M.I.F, when it is solid When determining on fucose, macrophage will not be started by MIF and hold inert condition, huge so as to be removed from infected point Phagocyte plays phagocytosis in immune response, is a factor for causing inflammation, macrophage is removed from infection point, can Reduction allergic reaction is reached to slow down the generation of inflammation.

Beta glucan has following features：(1) excellent immunoactivator；(2) powerful free radical scavenger；(3) activate Macrophage, bite neutrophil cell etc. remove cell disintegration fragment is caused by radiation；(4) macrophage can be made to distinguish and destruction change Idioblas；(5) damaged tissues are assisted, such as lymphocyte accelerates to recover to produce cytokine (IL-1)；(6) promote to include resisting Other drugs including raw plain, antimycotic and anti-parasitic medicine are preferably played effectiveness；(7) low density fat in blood is lowered, High density fat is improved, the generation of high fat of blood is reduced.

By according to said ratio by whitening composition (dimethoxy-p base -4- propyls diphenol, glabridin, cigarette Acid amides, 3-O- ethylascorbyls ether and peony root extractive) and ultra-violet absorber (butyl methoxy dibenzoyl Ji Jia Alkane) and moisturizing ingredient (hydroxy decyl ubiquinone, Sodium Hyaluronate, biological carbohydrate gum -1 and beta glucan) compatibility, can be more efficiently Stimulation of the ultraviolet radioactive to skin is reduced, the formation of melanin is prevented, and effectively protects skin, whitening spot-removing is reached, highlights The effect of the colour of skin and replenishing water and preserving moisture.

Wherein, thickener includes xanthans and hydroxyethyl cellulose.Specifically, in the raw material for preparing cream, xanthans Mass fraction be 0.1 part~0.3 part, the mass fraction of hydroxyethyl cellulose is 0.1 part~0.2 part.Xanthans can be provided Preferably resistance to ionic, Rong Naidu is strong, the skin sense that hydroxyethyl cellulose can be provided, according to aforementioned proportion simultaneously by xanthans With hydroxyethyl cellulose relatively good skin sense and proper viscosity can be provided as thickener.

Wherein, emulsifying agent includes stereth -2 and stereth -21.Specifically, the quality of stereth -2 Number is 1 part~4 parts, and the mass fraction of stereth -21 is 0.5 part~2.5 parts.Stereth -2 and stearyl alcohol are poly- Ether -21 is stronger for the emulsifying capacity of grease, and can provide relatively good skin sense, and the two compounding use can also mitigate breast Agent is to skin irritation, to improve the security of product.

Wherein, butanediol is the solvent of oil phase.

Further, preparing the raw material of cream also includes deionized water.Wherein, the mass fraction of deionized water be 38 parts~ 74 parts.Deionized water is the solvent of aqueous phase.

Further, preparing the raw material of cream also includes the preservative that mass fraction is 0.45 part~1.2 parts.Add anti-corrosion Agent can effectively suppress the generation of microorganism and bacterium.Specifically, preservative includes parahydroxyacet-ophenone and 1,2- hexylene glycol, right The mass fraction of hydroxy acetophenone is 0.25 part~0.6 part, and the mass fraction of 1,2- hexylene glycol is the 1,2- of 0.2 part~0.6 part Hexylene glycol.

The emollient of above-mentioned cream plays a part of moisturizing moisturizing, and butylmethoxydibenzoylmethane is inhaled for ultraviolet Agent is received, with sun-proof effect, dimethoxy-p base -4- propyls diphenol, glabridin, niacinamide, 3-O- ethyls resist Bad hematic acid ether and peony root extractive are whitening composition, and hydroxy decyl ubiquinone, Sodium Hyaluronate, biological carbohydrate gum -1 and beta glucan are Moisturizing ingredient, dimethoxy-p base -4- propyls diphenol suppresses the formation of TYR enzyme and TRP-1 enzymes, glabridin energy Inside deep enough skin, and high activity can be kept in skin, the effect with whitening and high-efficiency antioxidant can effectively suppress The activity of a variety of enzymes in melanin generating process, particularly suppresses TYR enzyme activity；Niacinamide can speed up metabolism, The horn cell containing melanin is promoted to come off, because Skin Cell needs sufficient energy to complete daily physiological function, Niacinamide can also promote the horn cell containing melanin to come off by accelerating skin to update, and act on produced black Pigment, is shifted with reducing it to cells of superficial layer, promotes the synthesis of epidermis protein, improves skin quality；3-O- ethyls are anti-bad Hematic acid ether is a kind of water-soluble vitamin c derivative of oleophylic, and this not only makes it extremely convenient can be used in formula, more Plus make it penetrate readily through cuticula to enter skin corium, and enter after skin the effect for easily being decomposed and being played Vc by biology enzyme, from And its bioavilability is improved, and common vitamin C is difficult then to be absorbed by the skin, bioavilability is very low；3-O- ethyls resist Bad hematic acid ether can be by suppressing the Cu of tyrosinase²⁺Formation that is active and blocking melanin, and prevent sun-induced skin Inflammation, improves skin colour, promotes collagen to produce, and increases skin elasticity；Peony root extractive has excellent antiallergy Effect, calm condition susceptible, complete inhibition role of complement activity completely inhibits the release of histamine, can almost completely inhibited The effect of the sour enzyme of bright matter, has good inhibitory action to direct cutaneous contact dermatitis, suppresses to be pitched by arachidonic acid and angle Glycosides lures the oedema of hair, suppresses the formation of melanin, suppresses the generation of oxygen radical, and oil-control peroxidization eliminates fat Property of overflowing dermatitis.By being used together according to upper proportioning so that cream can not suppress the formation of TYR enzyme, suppress TYR enzyme Activity, reduce melanin formation, while improve and promote collagen generation, increase skin elasticity, improve skin support Antianaphylactic function, controls fat secretion, to reach lifting skin and muscles are fair the beautiful purpose of penetrating health.And hydroxy decyl ubiquinone is A kind of fat-soluble antioxidant, improves body moisture-retaining capacity, the nutrition of energy human activin cell and cellular energy, with raising people The functions such as body immunity, the anti-oxidant, anti-aging of enhancing and enhancing human activity, Sodium Hyaluronate can play the protection skin of uniqueness Skin is acted on, and skin moisturizing can be kept smooth, fine and smooth tender, high resilience, with wrinkle resistant, crease-resistant, beauty and health care and recovery skin The effect of physiological function；The performance of keeping humidity of biological carbohydrate gum -1 is superior, very strong with water binding ability, in the environment of low humidity Soaking effect is good, while forming ventilative sugared film in skin surface, prevents moisture of skin from evaporating once again；Biological carbohydrate gum -1 is simultaneously Acted on instant and long-acting replenishing water and preserving moisture, and because the polysaccharide (1Mda) of pbz polymer amount causes biological carbohydrate gum -1 to have Film forming, with good moistening effect, while the water absorbing capacity of polysaccharide, strengthens its moistening effect, meanwhile, biological carbohydrate gum -1 The generation of inflammation can be slowed down and reduction allergic reaction is reached；It possesses excellent senile-resistant efficacy to beta glucan, can smooth Fine wrinkles, improve skin elasticity, improve dermatoglyph degree, with unique straight-chain molecular structure, impart good transdermal Absorbent properties, promote fibroblast synthesis collagen, promote wound healing, repair impaired skin, give skin such as silk As moisten anti-oxidant, Green Tea Extract the effect of smooth sense of touch, i.e. hydroxy decyl ubiquinone, pore and space between cells can be got through, Moisturizing, nutritional ingredient is made to rapidly enter skin base layer, to reach the purpose for nourishing moisturizing, biological carbohydrate gum -1 can be on skin Sebum diaphragm is formed, to prevent the loss of human body moisture while the phenomenon that there is the function of antiallergic to reduce pachylosis, transparent Matter acid sodium strengthens moisturizing moisturizing, and beta glucan promotes fibroblast synthesis collagen, promotes wound healing, repairs impaired flesh Skin, gives skin and smooth sense of touch is moistened such as silk, and by improving the moisturizing of cream according to aforementioned proportion collective effect Moisturizing ability, and reduce stimulation of the external substance to skin, to reach perfect combination that product is used, so that above-mentioned butyl methoxy Base dibenzoyl methane and above-mentioned whitening composition (dimethoxy-p base -4- propyls diphenol, glabridin, niacinamide, 3-O- ethylascorbyls ether and peony root extractive) and moisturizing ingredient (hydroxy decyl ubiquinone, Sodium Hyaluronate, biological carbohydrate gum -1 And beta glucan) compound use is carried out by said ratio, stimulation of the ultraviolet radioactive to skin can be more efficiently reduced, is hindered The only formation of melanin, and skin is effectively protected, reach the effect that whitening spot-removing, moisturizing are repaired.

And the experiment proved that, above-mentioned cream hardly produces stimulation to skin.

And without addition spices, mineral oil and parabens preservative in above-mentioned cream, use is safer.

As shown in figure 1, the preparation method of the cream of an embodiment, available for preparing above-mentioned cream, the preparation method bag Include following steps：

Step S110：Raw material is provided.

Wherein, according to mass fraction meter, raw material includes following component：14 parts~32.5 parts of emollient, 2 parts~5 parts Butylmethoxydibenzoylmethane, 0.5 part~1 part of dimethoxy-p base -4- propyls diphenol, 0.005 part~ 0.01 part of glabridin, 0.3 part~0.7 part of hydroxy decyl ubiquinone, 0.05 part~0.25 part of Sodium Hyaluronate, 1 part~5 parts Biological carbohydrate gum -1,1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~1.5 parts of 3-O- ethyls it is anti-bad Hematic acid ether, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 part~0.5 part of thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol.

Step S120：Glabridin, dimethoxy-p base -4- propyls diphenol, niacinamide, 3-O- ethyls is anti-bad Hematic acid ether, peony root extractive and butanediol mixed dissolution, obtain the first mixture.

Wherein, step S120 is carried out at room temperature.

Wherein, peony root extractive can be commercially available by market, such as the Peony white tree peonies of company are ground by upper Hisense Root extract；Also it can be prepared by using following steps：, can to moutan root bark ferment treatment 20min under conditions of 30 DEG C So that moutan root bark cell membrane and its interstitial structure produce the changes such as the loose of part, expansion, collapse；It is super to moutan root bark afterwards Sonication 30 minutes, ultrasonic wave produces strong shock wave and microjet in the inside of liquid, and this powerful impingement flow can have Block layer between the reduction of effect ground, elimination solvent and aqueous phase, so that mass transfer rate is increased, in addition, impingement flow is to cell tissue A kind of physical shear power is produced, is allowed to deform, ruptures, and discharges inclusion, is produced in cell membrane and its interstitial structure local Loose, the extraction process that expands, accelerate intracellular paeonol.Specifically, under conditions of 30 DEG C to moutan root bark enzyme Reason 20min method is that microbial fermentation processing is carried out by way of immersion.

Step S130：By thickener, Sodium Hyaluronate, beta glucan, dipotassium glycyrrhizinate, emulsifying agent, emollient and butyl Methoxy dibenzoylmethane is mixed with deionized water at 75 DEG C~85 DEG C, obtains the second mixed liquor.

Specifically, emollient includes propane diols, olive oil, Nexbase 2004, Permethyl 99A, the polydimethylsiloxanes of ring five Alkane, dimethyl silicone polymer, cetanol and stearyl alcohol；The mass fraction of propane diols is 2 parts~4 parts, the mass fraction of olive oil For 2 parts~4 parts, the mass fraction of Nexbase 2004 is 2 parts~4 parts, and the mass fraction of Permethyl 99A is 3 parts~8 parts, and ring five gathers The mass fraction of dimethyl siloxane is 2 parts~4 parts, the mass fraction of dimethyl silicone polymer for 0.5 part~1 part, cetanol Mass fraction be 0.5 part~2.0 parts, the mass fraction of stearyl alcohol is 0.5 part~2.0 parts.

Specifically, the preparation process of the second mixed liquor is specially：Deionized water, propane diols, Sodium Hyaluronate, β-Portugal are gathered Sugar and dipotassium glycyrrhizinate are mixed at 75 DEG C~85 DEG C, obtain the first premixed liquid；By emulsifying agent, olive oil, Nexbase 2004, different Dodecane, ring five dimethyl silicone polymer, dimethyl silicone polymer, cetanol, stearyl alcohol and butyl methoxy dibenzoyl base Methane is mixed at 75 DEG C~85 DEG C, obtains the second premixed liquid；Under conditions of 75 DEG C~85 DEG C, by the second premixed liquid and first Premixed liquid is mixed, and obtains the second mixed liquor.

Specifically, the step of the second premixed liquid being mixed with the first premixed liquid be specially：Under continuous agitation, will Second premix is added in the first premixed liquid, vacuum homogeneous 3 minutes~5 minutes at 75 DEG C~85 DEG C, stops 5 points of homogeneous Clock~10 minute, then homogeneous 3 minutes~5 minutes.

Specifically, by emulsifying agent, olive oil, Nexbase 2004, Permethyl 99A, ring five dimethyl silicone polymer, poly- diformazan In the step of radical siloxane, cetanol, stearyl alcohol and butylmethoxydibenzoylmethane are mixed at 75 DEG C~85 DEG C also Add preservative.Wherein, the mass fraction of preservative in the feed is 0.45 part~1.2 parts.Specifically, preservative include pair Hydroxy acetophenone and 1,2- hexylene glycol, the mass fraction of parahydroxyacet-ophenone is 0.25 part~0.6 part, the quality of 1,2- hexylene glycol Number is 0.2 part~0.6 part of 1,2- hexylene glycols.

Specifically, thickener includes xanthans and hydroxyethyl cellulose.The mass fraction of xanthans is 0.1 part~0.3 part, The mass fraction of hydroxyethyl cellulose is 0.1 part~0.2 part.

Wherein, emulsifying agent includes stereth -2 and stereth -21.Specifically, the quality of stereth -2 Number is 1 part~4 parts, and the mass fraction of stereth -21 is 0.5 part~2.5 parts.

Wherein, the mass fraction of deionized water is 38 parts~74 parts in step S130.

Step S140：Under conditions of 45 DEG C~50 DEG C, by the second mixed liquor, the first mixed liquor, biological carbohydrate gum -1 and hydroxyl Decyl ubiquinone is mixed, and obtains cream.

The preparation method of above-mentioned cream is simple to operate, it is easy to industrialized production.

For embodiment part, (following examples are not contained in addition to inevitable impurity unless otherwise specified, then below Other the component pointed out is not known.)：

Embodiment 1

The preparation process of the cream of the present embodiment is as follows：

(1) raw material is weighed, according to mass fraction meter, the raw material of the present embodiment is made up of following component：3.2 parts of propane diols, 2 parts of olive oil, 2 parts of Nexbase 2004,3 parts of Permethyl 99A, 2 parts of ring five dimethyl silicone polymer, dimethyl silicone polymer 0.5 Between part, 1 part of cetanol, 1.2 parts of stearyl alcohol, 2 parts of butylmethoxydibenzoylmethane, dimethoxy-p base -4- propyl group 0.5 part of benzenediol, 0.005 part of glabridin, 0.3 part of hydroxy decyl ubiquinone, 0.05 part of Sodium Hyaluronate, biological 2 parts of carbohydrate gum -1, 2 parts of beta glucan, 0.8 part of niacinamide, 1 part of 3-O- ethylascorbyls ether, 0.1 part of dipotassium glycyrrhizinate, peony root extractive 3 Part, 0.25 part of parahydroxyacet-ophenone, 0.2 part of 1,2- hexylene glycols, 0.2 part of xanthans, 0.2 part of hydroxyethyl cellulose, stearyl alcohol gather 64.495 parts of 2.5 parts of ether -2,1.5 parts of stereth -21,4 parts of butanediol and deionized water.

(2) by glabridin, dimethoxy-p base -4- propyls diphenol, niacinamide, 3-O- ethylascorbyls Ether, peony root extractive are mixed with butanediol, are disperseed and are dissolved, and obtain the first mixture.

(3) by deionized water, propane diols, Sodium Hyaluronate, beta glucan and dipotassium glycyrrhizinate emulsifying pot water Mixing is stirred at 80 DEG C in phase pot phase, the first premixed liquid is obtained.

(4) by stereth -2, stereth -21, olive oil, Nexbase 2004, Permethyl 99A, the poly- diformazan of ring five Radical siloxane, dimethyl silicone polymer, cetanol, stearyl alcohol, butylmethoxydibenzoylmethane and parahydroxyacet-ophenone Mixing is stirred at 80 DEG C in emulsifying pot, the second premixed liquid is obtained.

(5) under conditions of lasting stirring and 80 DEG C, the second premixed liquid is added to 4 points of vacuum homogeneous in the first premixed liquid Clock, stops homogeneous 8 minutes, then homogeneous 4 minutes, is then cooled to 0 DEG C, adds the first mixed liquor, biological carbohydrate gum -1 and hydroxy decyl Ubiquinone is mixed, after stirring, discharging, obtains cream, then through filling, packaging, inspection, vanning, packing and be put in storage.

Experiment test：

(a) irritation test

According to document OECD Guidelines for Testing of Chemicals (No.404, July 1992) and Method in USEPA OPPTS Harmonized Test Guidelines (Series 870.2500, Aug.1998) is carried out Acute skin irritation is tested, wherein, test object is rabbit (three).

Specific method is as follows：

About 24 hours before experiment, family's rabbit back backbone diamond wool is cut, epidermis can not be damaged, unhairing scope is left and right each About 2cm × 3cm；The cream about 0.5mL of the present embodiment is taken to be coated directly on skin, then with two layers of gauze (2.5cm × 2.5cm) With one layer of glassine paper or the like covering, then fixed with nonirritant adhesive plaster and bandage, opposite side skin is used as control；Adopt With blocking test, the application time is 4h；Then residual cream is removed with warm water；Remove cream after 1 hour, 24 hours, 48 Position dermoreaction is smeared in the observation of hour and 72 hours, and is scored according to table 1, is recorded according to 24 hours, 48 hours and 72 Hour observation time point top average, then judge skin irritatin intensity by table 2, the stimulation of the cream of the present embodiment to skin is strong Degree is shown in Table 3.

Table 1

Table 2

Integral mean value	Intensity
		0~＜ 0.5	It is nonirritant
0.5~＜ 2.0	Subexcite
		2.0~＜ 6.0	Moderate stimulation
6.0~8.0	Strong and stimulating

(b) whitening spot-removing measure of merit

Test object and processing：100 experimenters are chosen, side is bent in the left and right forearm of each experimenter and marks 3 × 3cm² The cream of the present embodiment is smeared in the square Experimental Area of size, the Experimental Area of left arm, and the Experimental Area of right arm is blank pair According to allowing 100 experimenters to be coated daily using the cream of the present embodiment on the Experimental Area of left arm once, continuously using 30 My god.

Because the color of human skin depends primarily on the content of melanin and ferroheme (haematochrome) in human body skin, because This, the whitening spot-removing effect of skin-protection product can be just known by the variable quantity of the melanin and ferroheme of testing skin, used South Korea LG Janus-1 skinanalysis apparatus directly measures the melanin of skin and the content of ferroheme, wherein, the measurement model of instrument It is 0~999 to enclose, and measured value is higher, illustrates that the content of melanin and ferroheme in skin is higher, tests 100 experimenters The melanin and the content of haematochrome of left arm and right arm before the cream using the present embodiment and after use, are calculated average respectively It is worth (round numbers), and average value is included in table 4.

(c) moistening effect test (test object processing is identical with whitening spot-removing measure of merit)

Test object is handled according to whitening spot-removing measure of merit identical method, because the moisture of skin surface contains Amount can reflect the moistening effect of moisturizer, and moisture is higher, and moistening effect is better.Using Corneometer CM825 Tester detects the moisture of the left arm of each experimenter and the Experimental Area of right arm, the left arm of each experimenter and right arm The equal duplicate measurements in Experimental Area 5 times, takes its average value, the average value of 100 experimenters is then taken again, and be included in table 4.

(d) skin carries luminance test

Test object is handled according to whitening spot-removing measure of merit identical method, due to the melanin pigment of skin The degree of deposition and skin brightness proportion relation, the degree of the melanin pigmentation of skin are smaller, and skin is brighter, because This, by detecting that melanin deposition degree can just reflect the brightness of skin, using model ewameter TM300 South Korea Skinanalysis apparatus detects the degree of the melanin deposition of the left arm of each experimenter and the skin of the Experimental Area of right arm, Mei Geshi The equal duplicate measurements of the left arm for the person of testing and the Experimental Area of right arm 5 times, takes its average value, and being averaged for 100 experimenters is then taken again Value, and be included in table 4.

Embodiment 2

The preparation process of the cream of the present embodiment is as follows：

(1) raw material is weighed, according to mass fraction meter, the raw material of the present embodiment by constituting component as follows：4 parts of propane diols, olive Olive oil 3 parts, 3 parts of Nexbase 2004,3 parts of Permethyl 99A, 2 parts of ring five dimethyl silicone polymer, 0.5 part of dimethyl silicone polymer, 2 parts of cetanol, 0.5 part of stearyl alcohol, 3 parts of butylmethoxydibenzoylmethane, dimethoxy-p base -4- propyls two 0.8 part of phenol, 0.008 part of glabridin, 0.7 part of hydroxy decyl ubiquinone, 0.08 part of Sodium Hyaluronate, biological 5 parts of carbohydrate gum -1, β-Portugal It is 5 parts of glycan, 1 part of niacinamide, 1.5 parts of 3-O- ethylascorbyls ether, 0.15 part of dipotassium glycyrrhizinate, 2 parts of peony root extractive, right 0.3 part of hydroxy acetophenone, 0.25 part of 1,2- hexylene glycols, 0.25 part of xanthans, 0.2 part of hydroxyethyl cellulose, stereth -2 39 parts of 1 part, 2.5 parts of stereth -21,3 parts of butanediol and deionized water.

(3) by deionized water, propane diols, Sodium Hyaluronate, beta glucan and dipotassium glycyrrhizinate emulsifying pot water Mixing is stirred at 75 DEG C in phase pot phase, the first premixed liquid is obtained.

(4) by stereth -2, stereth -21, olive oil, Nexbase 2004, Permethyl 99A, the poly- diformazan of ring five Radical siloxane, dimethyl silicone polymer, cetanol, stearyl alcohol, butylmethoxydibenzoylmethane and parahydroxyacet-ophenone Mixing is stirred at 75 DEG C in emulsifying pot, the second premixed liquid is obtained.

(5) under conditions of lasting stirring and 75 DEG C, the second premixed liquid is added to 5 points of vacuum homogeneous in the first premixed liquid Clock, stops homogeneous 5 minutes, then homogeneous 5 minutes, is then cooled to 45 DEG C, adds the first mixed liquor, biological carbohydrate gum -1 and hydroxy decyl The propylene glycol solution mixing of ubiquinone, after stirring, discharging obtains cream, then through filling, packaging, examine, vanning, packing and Storage.

The cream for obtaining the present embodiment using the test of the identical method of testing of embodiment 1 is shown in Table 3 to the stimulus intensity of skin, And use melanin content, the content of haematochrome, moisture and the melanin deposition journey before and after the cream of the present embodiment Degree is shown in Table 4.

Embodiment 3

The preparation process of the cream of the present embodiment is as follows：

(1) raw material is weighed, according to mass fraction meter, the raw material of the present embodiment by constituting component as follows：2 parts of propane diols, olive 4 parts of olive oil, 4 parts of Nexbase 2004,8 parts of Permethyl 99A, 4 parts of ring five dimethyl silicone polymer, 1 part of dimethyl silicone polymer, whale 0.5 part of ceryl alcohol, 2 parts of stearyl alcohol, 5 parts of butylmethoxydibenzoylmethane, dimethoxy-p base -4- propyl diphenol 1 part, 0.01 part of glabridin, 0.5 part of hydroxy decyl ubiquinone, 0.25 part of Sodium Hyaluronate, biological 1 part of carbohydrate gum -1, beta glucan 1 Part, 0.5 part of niacinamide, 0.5 part of 3-O- ethylascorbyls ether, 0.3 part of dipotassium glycyrrhizinate, 5 parts of peony root extractive, to hydroxyl It is 0.6 part of acetophenone, 0.2 part of 1,2- hexylene glycols, 0.3 part of xanthans, 0.1 part of hydroxyethyl cellulose, 4 parts of stereth -2, hard - 21 0.5 parts of lipidol polyethers, 6 parts of butanediol, 74 parts of deionized water.

(3) by deionized water, propane diols, Sodium Hyaluronate, beta glucan and dipotassium glycyrrhizinate emulsifying pot water Mixing is stirred at 85 DEG C in phase pot phase, the first premixed liquid is obtained.

(4) by stereth -2, stereth -21, olive oil, Nexbase 2004, Permethyl 99A, the poly- diformazan of ring five Radical siloxane, dimethyl silicone polymer, cetanol, stearyl alcohol, butylmethoxydibenzoylmethane and parahydroxyacet-ophenone Mixing is stirred at 85 DEG C in emulsifying pot, the second premixed liquid is obtained.

(5) under conditions of lasting stirring and 85 DEG C, the second premixed liquid is added to 5 points of vacuum homogeneous in the first premixed liquid Clock, stops homogeneous 10 minutes, then homogeneous 3 minutes, is then cooled to 45 DEG C, adds the first mixed liquor, biological carbohydrate gum -1 and the hydroxyl last of the ten Heavenly stems The propylene glycol solution mixing of base ubiquinone, after stirring, discharging obtains cream, then through filling, packaging, inspection, vanning, packing And storage.

Comparative example 1

Comparative example 1 is the whitening and spot eliminating cream of Rou Ligao daily-use chemical industries Co., Ltd of Shenzhen.

Tested using the identical method of testing of embodiment 1 obtain comparative example 1 cream be shown in Table 3 to the stimulus intensity of skin, And front and rear melanin content, the content of haematochrome, moisture and the melanin deposition of the cream using comparative example 1 Degree is shown in Table 4.

Comparative example 2

The preparation process of the cream of comparative example 2 is as follows：

(1) raw material is weighed, according to mass fraction meter, the raw material of the present embodiment is made up of following component：3.2 parts of propane diols, 2 parts of olive oil, 2 parts of Nexbase 2004,3 parts of Permethyl 99A, 2 parts of ring five dimethyl silicone polymer, dimethyl silicone polymer 0.5 Between part, 1 part of cetanol, 1.2 parts of stearyl alcohol, 2 parts of butylmethoxydibenzoylmethane, dimethoxy-p base -4- propyl group 0.5 part of benzenediol, 0.3 part of hydroxy decyl ubiquinone, 0.05 part of Sodium Hyaluronate, biological 2 parts of carbohydrate gum -1,2 parts of beta glucan, nicotinoyl 0.817 part of amine, 1 part of 3-O- ethylascorbyls ether, 0.1 part of dipotassium glycyrrhizinate, 3 parts of peony root extractive, parahydroxyacet-ophenone 0.25 part, it is 0.2 part of 1,2- hexylene glycols, 0.2 part of xanthans, 0.2 part of hydroxyethyl cellulose, 2.5 parts of stereth -2, stearic 64.495 parts of -21 1.5 parts of alcohol polyethers, 4 parts of butanediol and deionized water.

(2) dimethoxy-p base -4- propyls diphenol, niacinamide, 3-O- ethylascorbyls ether, tree peony root are carried Take thing to be mixed with butanediol, disperseed and dissolved, obtain the first mixture.

The cream for obtaining comparative example 1 using the test of the identical method of testing of embodiment 1 is shown in Table 3 to the stimulus intensity of skin, And front and rear melanin content, the content of haematochrome, moisture and the melanin deposition of the cream using comparative example 1 Degree is shown in Table 4.

Comparative example 3

The preparation process of the cream of comparative example 3 is as follows：

(1) raw material is weighed, according to mass fraction meter, the raw material of the present embodiment is made up of following component：3.2 parts of propane diols, 2 parts of olive oil, 2 parts of Nexbase 2004,3 parts of Permethyl 99A, 2 parts of ring five dimethyl silicone polymer, dimethyl silicone polymer 0.5 Part, 1 part of cetanol, 1.2 parts of stearyl alcohol, 2 parts of butylmethoxydibenzoylmethane, 0.3 part of hydroxy decyl ubiquinone, hyaluronic acid 0.05 part of sodium, biological 2 parts of carbohydrate gum -1,2 parts of beta glucan, 2.305 parts of glabridin, 0.1 part of dipotassium glycyrrhizinate, tree peony root are carried Take 3 parts of thing, 0.25 part of parahydroxyacet-ophenone, 0.2 part of 1,2- hexylene glycols, 0.2 part of xanthans, 0.2 part of hydroxyethyl cellulose, tristearin 64.495 parts of -2 2.5 parts of alcohol polyethers, 1.5 parts of stereth -21,4 parts of butanediol and deionized water.

(2) dimethoxy-p base -4- propyls diphenol, glabridin are mixed with butanediol, carried out scattered and molten Solution, obtains the first mixture.

What table 3 was represented is stimulus intensity of the cream to skin of embodiment 1~3 and comparative example 1~3.

Table 3

	Embodiment 1	Embodiment 2	Embodiment 3	Comparative example 1	Comparative example 2	Comparative example 3
							Stimulus intensity	0	0	0	2	0	0

From table 3 it is observed that the cream of embodiment 1~3 is 0 to the stimulus intensity of skin, it is clear that the present embodiment 1~3 Cream it is non-stimulated to skin.

What table 4 was represented is that the melanin of left arm before and after cream using embodiment 1~3 and comparative example 1~3 and right arm contains Amount, red cellulose content, moisture and pigment (melanin) deposition degree.

Table 4

As can be seen from Table 4, using 1~embodiment of embodiment 3 cream left arm melanin and haematochrome distinguish 817 and 122 are at least reduced, and 200 Hes are only reduced respectively using the melanin and haematochrome of the left arm of the cream of comparative example 1 30, effect is nothing like the cream of 1~embodiment of embodiment 3, it is clear that the cream of 1~embodiment of embodiment 3 has more preferable beautiful The effect of white nti-freckle.

And at least improve 45, the deposition of melanin using the moisture of the left arm of the cream of 1~embodiment of embodiment 3 Degree also at least reduces 55, and only improves 15, the deposition journey of melanin using the moisture of the left arm of the cream of comparative example 1 Degree also reduced by only 15, it is clear that by contrast, and the cream of 1~embodiment of embodiment 3 has more preferable moisturizing and improves brightness Effect.

And it can also be seen that being reduced respectively using the melanin and haematochrome of the left arm of the cream of embodiment 1 from table 1 817 and 122, moisture improves 45, and the deposition degree of melanin also reduces 55, and using the difference with embodiment 1 only Be not use glabridin and niacinamide fill up embodiment 1 glabridin amount comparative example 2 cream left arm Melanin and haematochrome only reduce 440 and 90 respectively, and moisture improves 27, and the deposition degree of melanin reduces 40, And using comparative example 3 do not have dimethoxy-p base -4- propyls diphenol, niacinamide, 3-O- ethylascorbyls ether and Peony root extractive, and fill up dimethoxy-p base -4- propyls diphenol, niacinamide, 3-O- ethyls using glabridin The melanin and haematochrome of the left arm of the cream of the content of ascorbic acid ether and peony root extractive reduce 610 and 75 respectively, Moisture improves 30, and the deposition degree of melanin also reduces 35, well below embodiment 1 cream effect, and Glabridin and dimethoxy-p base -4- propyls diphenol, niacinamide, 3-O- ethylascorbyls ether and tree peony root are carried Thing is taken while using, can make cream that there is more preferable whitening spot-removing, moisturizing and the effect for improving brightness.

Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, the scope of this specification record is all considered to be.

Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously Can not therefore it be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.

Claims

1. a kind of cream, it is characterised in that according to mass fraction meter, preparing the raw material of the cream includes：14 parts~32.5 parts Emollient, 2 parts~5 parts of butylmethoxydibenzoylmethane, 0.5 part~1 part of dimethoxy-p base -4- propyl group Resorcinol, 0.005 part~0.01 part of glabridin, 0.3 part~0.7 part of hydroxy decyl ubiquinone, 0.05 part~0.25 part Sodium Hyaluronate, 1 part~5 parts of biological carbohydrate gum -1,1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~ 1.5 parts of 3-O- ethylascorbyls ether, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 Part~0.5 part of thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol.

2. cream according to claim 1, it is characterised in that the emollient includes propane diols, olive oil, hydrogenates the poly- last of the ten Heavenly stems Alkene, Permethyl 99A, ring five dimethyl silicone polymer, dimethyl silicone polymer, cetanol and stearyl alcohol.

3. cream according to claim 2, it is characterised in that the mass fraction of the propane diols is 2 parts~4 parts, described The mass fraction of olive oil is 2 parts~4 parts, and the mass fraction of the Nexbase 2004 is 2 parts~4 parts, the Permethyl 99A Mass fraction is 3 parts~8 parts, and the mass fraction of the ring five dimethyl silicone polymer is 2 parts~4 parts, the poly dimethyl silicon The mass fraction of oxygen alkane is 0.5 part~1 part, and the mass fraction of the cetanol is 0.5 part~2.0 parts, the matter of the stearyl alcohol It is 0.5 part~2.0 parts to measure number.

4. cream according to claim 1, it is characterised in that the thickener includes xanthans and hydroxyethyl cellulose.

5. cream according to claim 1, it is characterised in that the emulsifying agent includes stereth -2 and stearyl alcohol is poly- Ether -21.

6. cream according to claim 1, it is characterised in that the raw material for preparing the cream also includes mass fraction For 0.45 part~1.2 parts of preservative.

7. a kind of preparation method of cream, it is characterised in that comprise the following steps：

Raw material is provided, wherein, according to mass fraction meter, the raw material includes following component：14 parts~32.5 parts of emollient, 2 Part~5 parts of butylmethoxydibenzoylmethane, 0.5 part~1 part of dimethoxy-p base -4- propyls diphenol, 0.005 part~0.01 part of glabridin, 0.3 part~.07 parts of hydroxy decyl ubiquinone, 0.05 part~0.25 part of hyaluronic acid Sodium, 1 part~5 parts of biological carbohydrate gum -1,1 part~5 parts of beta glucan, 0.5 part~1 part of niacinamide, 0.5 part~1.5 parts 3-O- ethylascorbyls ether, 0.1 part~0.3 part of dipotassium glycyrrhizinate, 2 parts~5 parts of peony root extractive, 0.2 part~0.5 The thickener, 1.5 parts~6.5 parts of emulsifying agent and 3 parts~6 parts of butanediol of part；

By the glabridin, the dimethoxy-p base -4- propyls diphenol, the niacinamide, the 3-O- ethyls Ascorbic acid ether, the peony root extractive and the butanediol mixed dissolution, obtain the first mixture；

By the thickener, the Sodium Hyaluronate, the beta glucan, the dipotassium glycyrrhizinate, the emulsifying agent, the profit Skin agent and the butylmethoxydibenzoylmethane are mixed with deionized water at 75 DEG C~85 DEG C, obtain the second mixing Liquid；And

Under conditions of 45 DEG C~50 DEG C, by second mixed liquor, first mixed liquor, the biological carbohydrate gum -1 and described Hydroxy decyl ubiquinone is mixed, and obtains cream.

8. the preparation method of cream according to claim 7, it is characterised in that the emollient includes propane diols, olive Oil, Nexbase 2004, Permethyl 99A, ring five dimethyl silicone polymer, dimethyl silicone polymer, cetanol and stearyl alcohol, and institute The mass fraction for stating propane diols is 2 parts~4 parts, and the mass fraction of the olive oil is 2 parts~4 parts, the Nexbase 2004 Mass fraction is 2 parts~4 parts, and the mass fraction of the Permethyl 99A is 3 parts~8 parts, the ring five dimethyl silicone polymer Mass fraction is 2 parts~4 parts, and the mass fraction of the dimethyl silicone polymer is 0.5 part~1 part, the quality of the cetanol Number is 0.5 part~2.0 parts, and the mass fraction of the stearyl alcohol is 0.5 part~2.0 parts；

Wherein, the preparation process of second mixed liquor is specially：By the deionized water, the propane diols, the hyalomitome Sour sodium, the beta glucan and the dipotassium glycyrrhizinate are mixed at 75 DEG C~85 DEG C, obtain the first premixed liquid；By the emulsification Agent, the olive oil, the Nexbase 2004, the Permethyl 99A, the ring five dimethyl silicone polymer, the poly dimethyl Siloxanes, the cetanol, the stearyl alcohol and the butylmethoxydibenzoylmethane are mixed at 75 DEG C~85 DEG C, Obtain the second premixed liquid；Under conditions of 75 DEG C~85 DEG C, second premixed liquid is mixed with first premixed liquid, obtained Second mixed liquor.

9. the preparation method of cream according to claim 8, it is characterised in that it is described by second premixed liquid with it is described The step of first premixed liquid is mixed be specially：Under continuous agitation, second premix is added to described In one premixed liquid, vacuum homogeneous 3 minutes~5 minutes at 75 DEG C~85 DEG C stop homogeneous 5 minutes~10 minutes, then 3 points of homogeneous Clock~5 minute.