CN106726907A - A kind of cosmetics skin whitener and preparation method thereof - Google Patents

A kind of cosmetics skin whitener and preparation method thereof Download PDF

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Publication number
CN106726907A
CN106726907A CN201611129586.7A CN201611129586A CN106726907A CN 106726907 A CN106726907 A CN 106726907A CN 201611129586 A CN201611129586 A CN 201611129586A CN 106726907 A CN106726907 A CN 106726907A
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China
Prior art keywords
extract
skin whitener
cosmetics
peony
skin
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CN201611129586.7A
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Chinese (zh)
Inventor
马萍
霍刚
周莹
张丽华
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Ou Shi Overflows Biological Co Ltd
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Ou Shi Overflows Biological Co Ltd
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Priority to CN201611129586.7A priority Critical patent/CN106726907A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The present invention relates to cosmetic field, and in particular to a kind of cosmetics skin whitener and preparation method thereof.A kind of cosmetics skin whitener, the whitening emulsion includes following component by mass percentage:Glycyrrhiza glabra root extract 0.0015 ~ 0.2, niacinamide 0.1 ~ 10, moutan root bark extract 0.001 ~ 0.1, pale flag root extract 0.1 ~ 10;Other cosmetics skin whiteners often use matrix components 60% ~ 80%.The active component that the present invention is wanted based on various natural plant extracts and natural flower extract, collaboration plays a role, and suppresses melanin generation, removes free radical, reaches the effect of skin-whitening.

Description

A kind of cosmetics skin whitener and preparation method thereof
Technical field
The present invention relates to cosmetic field, and in particular to a kind of cosmetics skin whitener and preparation method thereof.
Background technology
Containing 4%~5% chromatophore in the basal layer cell of human epidermal.The color of human skin is not depend on black Chromatophore quantity, but depending on the quantity of melanosome, size, distribution and melanocyte degree.And tyrosinase is black The first step rate-limiting enzyme and key enzyme of element synthesis.Therefore, tyrosinase inhibitor is all contained in most of whitening agents, by influence Formation, transfer of melanosome etc. reach the effect of whitening.
Tyrosinase is a kind of cupric aerobic enzyme, in the course of reaction that tyrosine is converted into DOPA, it is necessary to aerobic freedom Base is participated in.That is, oxygen radical is both initiator and reactant, the process of the catalysis oxidation of tyrosinase, in fact It is the process that free radical is removed in human body.The removing of oxygen radical can block the catalytic reaction of tyrosinase, so that junket ammonia The remitted its fury of acid oxidase reaction.Simultaneously as oxygen radical is considered as to cause the important of skin senescence to want one of reason, therefore Scavenging activated oxygen is increasingly paid attention to when design is formulated.
Make product whitening effect significantly, except considering the reason for melanin is formed, it is also one to remove free radical anti-oxidant Individual importance, can only in this way design efficient whitening product.But, multipath acts on the generation of melanin and turns Move past journey, it is necessary to consider security, stability and the outward appearance of product.Therefore, from have it is multi-functional, stable, safely and Whitening raw material of light color, plays its collaboration whitening function, has great importance.
The Chinese invention patent of applicant's application(201510116273.7 applying date of application number 2015.03.17)It is open A kind of cosmetic composition for skin whitening, said composition includes following component:Pearl powder, Margarita extract, light Fruit glycyrrhizic aqueous solution, hydrolysis conchiolin and Semen Pisi sativi extract, pearl powder is zero when different with the content of Margarita extract, and The percentage composition of glycyrrhiza glabra extract is 0.5 ~ 5.0% in the described glycyrrhiza glabra aqueous solution.In the skin lightening compositions Margarita extract contains pearl native polypeptide and various necessary amino acid, and pearl native polypeptide has suppression Endothelin activation junket ammonia Sour enzyme and suppression Endothelin promote the effect of Differentiation of Melanocytes, and amino acid can promote Skin Cell to increase, suppress junket ammonia Sour enzymatic enters to generate melanin activity, removes the multi abilities such as free radical.
Applicant has applied for Chinese invention patent(Application number:2016101689699, the applying date:2016-03-23)It is open A kind of cosmetic composition, said composition includes following component as mass fraction:Glycyrrhiza glabra root extract 0.0015 ~ 0.2, niacinamide 0.1 ~ 10, moutan root bark extract 0.1 ~ 5, pale flag root extract 0.1 ~ 10.But due to tree peony Root bark extract has stronger smell, therefore has inappropriate smell to produce when in use.
The content of the invention
The reason for synthesis melanin of the invention is formed, one object of the present invention proposes a kind of cosmetics skin whitener.This hair Second bright purpose is to provide the preparation method of above-mentioned cosmetics skin whitener, and the cosmetics skin whitener is with various natural plants The active component wanted based on extract and natural flower extract, collaboration plays a role, and suppresses melanin generation, removes free radical, Reach the effect of skin-whitening.
In order to realize first above-mentioned purpose, present invention employs following technical scheme:
A kind of cosmetics skin whitener, the skin whitener includes following component by mass percentage:
Glycyrrhiza glabra root extract 0.0015 ~ 0.2%
Niacinamide 0.1 ~ 10%
Moutan root bark extract 0.001 ~ 0.1%
Pale flag root extract 0.1 ~ 10%;
Other cosmetics skin whiteners often use matrix components 60% ~ 80%.
Preferably, the skin whitener includes following component by mass percentage:
Glycyrrhiza glabra root extract 0.005 ~ 0.1%
Niacinamide 0.1 ~ 10%
Moutan root bark extract 0.01 ~ 0.09%
Pale flag root extract 0.1 ~ 5%;
Other cosmetics skin whiteners often use matrix components 60% ~ 90%.
Preferably, the skin whitener also includes Flos persicae extract, safflower extract, in peony extract and peony water One or more mixing.
Used as further preferably, the skin whitener includes following component by mass percentage:
Flos persicae extract 0 ~ 5%
Safflower extract 0 ~ 5%
Peony extract 0 ~ 5%
Peony water 0 ~ 5%;
Wherein, Flos persicae extract, safflower extract, peony extract is zero when different with the content of peony water.
Above-mentioned Flos persicae extract, safflower extract and peony extract are respectively the extracted system of peach blossom, safflower, peony Standby extract.Peony water condenses the extract for preparing for peony carries out distillation.
Preferably, described Flos persicae extract quality purity is 1 ~ 2%;Described safflower extract quality purity be 1 ~ 2%;Described peony extract quality purity is 1 ~ 2%;Described peony water quality purity is 1 ~ 2%.
Preferably, glabridin content is not less than 90% in glycyrrhiza glabra root extract;Moutan root bark extract is from male Extracted in the root skin of pellet flower, its main active is Paeonol, moutan root bark extract mass concentration is 99%;It is fragrant Root orrisroot extract quality purity is more than or equal to 5%.
Preferably, other cosmetics skin whiteners often with matrix components include emulsifying agent, emollient, NMF, thickener, Preservative, essence and water.
Preferably, it is by following component based on 100% by the skin whitener with matrix components that other cosmetics skin whiteners are normal Constitute:
Emulsifying agent 0.1 ~ 5%;
Emollient 1 ~ 20%;
NMF 1 ~ 20%
Thickener 0.1 ~ 5%;
Preservative 0.05 ~ 1%
Essence 0.05 ~ 1%;
Water 50 ~ 70%.
Preferably, it is by following component based on 100% by the skin whitener with matrix components that other cosmetics skin whiteners are normal Constitute:
The 1,3- propane diols 2 ~ 10% of 50 ~ 60% glycerine of water 2 ~ 10%
The cetostearyl alcohol ethylhexoate 2 ~ 10% of 0.1 ~ 1% sodium phytate of lecithin 0.02 ~ 0.1%
The Parleam 2 ~ 10% of 0.5 ~ 5% hexyl decyl alcohol of olive oil 2 ~ 10%
The methyl sesquistearate 0.5 ~ 5% of 0.5 ~ 5% tocopherol acetate of docosyl alcohol 0.1 ~ 2%
The dimethyl silicone polymer 0.5 ~ 5% of PEG-20 methyls sesquistearate 0.5 ~ 5%
Acrylic acid (ester) class/aminomethyl propanol 0.1 ~ 1% of C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1 ~ 2%
The bisabolol 0.05 ~ 1% of 0.1 ~ 2% essence of Phenoxyethanol 0.1 ~ 1%.
In order to realize second above-mentioned purpose, present invention employs following technical scheme:
A kind of method for preparing cosmetics skin whitener, the method comprises the following steps:
1)After water, glycerine, 1,3-PD, lecithin, sodium phytate are uniformly mixed, 75 ~ 80 DEG C are heated with stirring to, at a high speed 10 ~ 30min of homogeneous;
2)By cetostearyl alcohol ethylhexoate, olive oil, hexyl decyl alcohol, Parleam, docosyl alcohol, tocopherol second Acid esters, methyl sesquistearate, PEG-20 methyl sesquistearates are heated with stirring to 75 ~ 80 DEG C, and dissolving is equal It is even;Add dimethyl silicone polymer, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers;
3)By above-mentioned steps 2)Obtained composition adds step 1)In obtained composition, 1 ~ 5min of high speed homogenization adds aminomethyl Propyl alcohol;
4)Stirring is cooled to 40 ~ 45 DEG C, adds Phenoxyethanol, essence, bisabolol, glycyrrhiza glabra root extract, niacinamide, male Red root bark extract and pale flag root extract, stirring are cooled to room temperature.
Described glycyrrhiza glabra root extract of the present invention is extracted by the glycyrrhiza glabra root of artificial cultivation, Its quality purity is more than 90%.The active component of glycyrrhiza glabra root extract is glabridin, and glabridin has significant anti-inflammatory And whitening effect, glabridin is published as having checked and approved one of license, most safe, most effective whitening composition in the world, it is industry The generally acknowledged whitening gold in boundary, exists only in the root of glycyrrhiza glabra.But find in the application, the low mixture of glabridin purity With color and luster, and the color burn under the conditions of temperature is high, the so color and luster to cosmetics have an impact.And the light used in the present invention Glabridin content is not less than 90% in fruit licorice root extract, therefore smaller for cosmetic color influence in use.
Niacinamide of the invention, also known as VB3, is the biologically active form of nicotinic acid, in seeing various animals and plants extensively.It It is confactor NADH(NADH)And NADPH(Nicotinamide-adenine dinucleotide phosphate)It is important before Body.They play a part of coenzyme together with reduced-NAD H and NADPH in more than 40 kinds of biochemical reactions, may also function as antioxygen The effect of agent.Acid amides can lower the melanosome transhipment from melanocyte to keratinocyte, without suppressing tyrosine enzyme activity Property or cell propagation, so as to influence cutaneous pigmentation, it can also disturb the cell signal between keratinocyte and melanocyte Passage, reduces melanogenesis.On the other hand, niacinamide can act on the melanin for having produced, and reduce it and turn to cells of superficial layer Move.
Paeonol contained by moutan root bark extract of the invention can effectively suppress the activity of tyrosinase, reduce black The content of element.Pale flag root extract, safflower flower extract, Flos persicae extract, Chinese herbaceous peony flower extract in the present invention and male Pellet flower water, containing flavonoids, vitamin C, Polyphenols and glucide, the ability with stronger scavenging activated oxygen, so that Anti-oxidation efficacy is reached, desalinates color spot, make skin that gloss is presented.
The present invention as a result of above-mentioned technical scheme, based on various natural plant extracts and natural flower extract The active component wanted, collaboration plays a role, and suppresses melanin generation, removes free radical, reaches the effect of skin-whitening.
Brief description of the drawings
Fig. 1 is subject's face-image example.
Fig. 2 is formulation principle figure of the invention.
Specific embodiment
The skin whitening cosmetics skin whitener that the present invention is provided is to contain glycyrrhiza glabra root extract, niacinamide, tree peony Root bark extract, pale flag root extract, Flos persicae extract, safflower flower extract, peony extract, peony water is main Composition, is aided with cosmetics and is often made of matrix components emulsifying agent, emollient, NMF, thickener, preservative, essence and water. A part of specific embodiment is set forth below, and the present invention will be described, but is not intended to limit present disclosure.
The skin whitener of embodiment 1:
The component and its relative content for constituting above-mentioned skin whitener be:
Glycerine 5
1,3- propane diols 5
Lecithin 0.4
Sodium phytate 0.05
Cetostearyl alcohol ethylhexoate 6
Olive oil 2
Hexyl decyl alcohol 4
Parleam 4
Docosyl alcohol 2
Tocopherol acetate 0.4
Methyl sesquistearate 2
PEG-20 methyl sesquistearates 2.5
Dimethyl silicone polymer 2
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers 0.4
Aminomethyl propanol 0.25
Phenoxyethanol 0.6
Essence 0.25
Bisabolol 0.15
Glycyrrhiza glabra root extract 0.06
Niacinamide 2
Moutan root bark extract 0.01
Peony water 2
Pale flag root extract 0.8
Water Surplus
The preparation method of above-mentioned skin whitener 1, comprises the following steps:
1st, after Jiang Shui, glycerine, 1,3-PD, lecithin, sodium phytate are uniformly mixed, 75 ~ 80 DEG C are heated with stirring to, at a high speed Homogeneous 20min;
2nd, by cetostearyl alcohol ethylhexoate, olive oil, hexyl decyl alcohol, Parleam, docosyl alcohol, tocopherol second Acid esters, methyl sesquistearate, PEG-20 methyl sesquistearates are heated with stirring to 75 ~ 80 DEG C, and dissolving is equal It is even.Add dimethyl silicone polymer, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers;
3rd, above-mentioned 2 are added in 1, high speed homogenization 3min, adds aminomethyl propanol;
4th, stirring is cooled to 40 ~ 45 DEG C, adds Phenoxyethanol, essence, bisabolol, glycyrrhiza glabra root extract, niacinamide, male Red root bark extract, peony water and pale flag root extract, stirring are cooled to room temperature.
Embodiment 2
Skin whitener:
The component and its relative content for constituting above-mentioned skin whitener be:
Glycerine 5
1,3- propane diols 5
Lecithin 0.4
Sodium phytate 0.05
Cetostearyl alcohol ethylhexoate 6
Olive oil 2
Hexyl decyl alcohol 4
Parleam 4
Docosyl alcohol 2
Tocopherol acetate 0.4
Methyl sesquistearate 2
PEG-20 methyl sesquistearates 2.5
Dimethyl silicone polymer 2
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers 0.4
Aminomethyl propanol 0.25
Phenoxyethanol 0.6
Essence 0.25
Bisabolol 0.15
Glycyrrhiza glabra root extract 0.1
Niacinamide 0.5
Moutan root bark extract 0.05
Peony water 1
Flos persicae extract 1
Safflower extract 1
Peony extract 1
Pale flag root extract 2.0
Water Surplus
The preparation method of above-mentioned skin whitener 1, comprises the following steps:
1st, after Jiang Shui, glycerine, 1,3-PD, lecithin, sodium phytate are uniformly mixed, 75 ~ 80 DEG C are heated with stirring to, at a high speed Homogeneous 20min;
2nd, by cetostearyl alcohol ethylhexoate, olive oil, hexyl decyl alcohol, Parleam, docosyl alcohol, tocopherol second Acid esters, methyl sesquistearate, PEG-20 methyl sesquistearates are heated with stirring to 75 ~ 80 DEG C, and dissolving is equal It is even.Add dimethyl silicone polymer, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers;
3rd, above-mentioned 2 are added in 1, high speed homogenization 3min, adds aminomethyl propanol;
4th, stirring is cooled to 40 ~ 45 DEG C, adds Phenoxyethanol, essence, bisabolol, glycyrrhiza glabra root extract, niacinamide, male Red root bark extract, peony water, Flos persicae extract, safflower extract, peony extract, pale flag root extract, stirring It is cooled to room temperature.
Test example whitening effect is evaluated
The skin whitener provided in this experimental selection embodiment 1 carries out clinical trial.
The experiment includes 22 volunteers, and in 21-45 one full year of life, face had due to Exposure to Sunlight, operating pressure, age female age Etc. the spot for causing.Tested material and all information are used according to regulations during testing.Skin whitener is smeared twice sooner or later daily, is tested Cycle is 4 weeks.In W0(Using preceding), W2 (use 2 weeks), W4(Use 4 weeks)Face image data is obtained by VISIA-CR, and With the change of SSA software analysis face particular spots L* values, and with its otherness of t inspections.Its result is as follows:
1.L, a, b value changes table
Note:* represents difference highly significant(P<0.01)
Be can see from table, it can be seen that using after two weeks, skin colourity L* values just have increase trend, and are significantly greater than Using preceding level, difference has statistical significance(p<0.01), while a values and b values are respectively provided with downward trend, difference has system Meter learns meaning(p<0.01)).Face is illustrated using after skin whitener, skin color gradually brightens and color spot color gradually becomes It is light.
2. facial colour spot example images are as shown in Figure 1.
It will be noted from fig. 1 that when W2, facial colour spot is substantially desalinated, and there can be one when W4 very Good maintenance effect.With the L of face, a, b value result is consistent.
In sum, the whitening product has significant white-skinned face function, i.e., dual with desalination color spot with bright color Effect.

Claims (10)

1. a kind of cosmetics skin whitener, it is characterised in that the skin whitener includes following component by mass percentage:
Glycyrrhiza glabra root extract 0.0015 ~ 0.2%
Niacinamide 0.1 ~ 10%
Moutan root bark extract 0.001 ~ 0.1%
Pale flag root extract 0.1 ~ 10%;
Other cosmetics skin whiteners often use matrix components 60% ~ 90%.
2. a kind of cosmetics skin whitener according to claim 1, it is characterised in that the skin whitener is wrapped by mass percentage Include following component:
Glycyrrhiza glabra root extract 0.005 ~ 0.1%
Niacinamide 0.1 ~ 10%
Moutan root bark extract 0.01 ~ 0.09%
Pale flag root extract 0.1 ~ 5%;
Other cosmetics skin whiteners often use matrix components 60% ~ 90%.
3. a kind of cosmetics skin whitener according to claim 1 and 2, it is characterised in that the skin whitener is also extracted including peach blossom Thing, safflower extract, one or more mixing in peony extract and peony water.
4. a kind of cosmetics skin whitener according to claim 3, it is characterised in that the skin whitener is wrapped by mass percentage Include following component:
Flos persicae extract 0 ~ 5%
Safflower extract 0 ~ 5%
Peony extract 0 ~ 5%
Peony water 0 ~ 5%;
Wherein, Flos persicae extract, safflower extract, peony extract is zero when different with the content of peony water.
5. a kind of cosmetics skin whitener according to claim 3 or 4, it is characterised in that:Described Flos persicae extract quality Purity is 1 ~ 2%;Described safflower extract quality purity is 1 ~ 2%;Described peony extract quality purity is 1 ~ 2%;Institute The peony water quality purity stated is 1 ~ 2%.
6. a kind of cosmetics skin whitener according to claim 1 ~ 4 any one claim, it is characterised in that:Light fruit is sweet Glabridin content is not less than 90% in grass roots extract;Moutan root bark extract is extracted from the root skin of peony, Its main active is Paeonol, and moutan root bark extract mass concentration is 99%;Pale flag root extract quality purity is More than or equal to 5%.
7. a kind of cosmetics skin whitener according to claim 1 ~ 6 any one claim, it is characterised in that:Other are changed Cosmetic emulsion often includes that the one kind in emulsifying agent, emollient, NMF, thickener, preservative, essence and water is mixed with matrix components Various mixing.
8. a kind of cosmetics skin whitener according to claim 7, it is characterised in that other cosmetics skin whiteners often use base Matter composition is to be made up of following component based on 100% by the skin whitener:
Emulsifying agent 0.1 ~ 5%;
Emollient 1 ~ 20%;
NMF 1 ~ 20%
Thickener 0.1 ~ 5%;
Preservative 0.05 ~ 1%
Essence 0.05 ~ 1%;
Water 50 ~ 70%.
9. a kind of cosmetics skin whitener according to claim 1 ~ 8 any one claim, it is characterised in that this other It is to be made up of following component based on 100% by the skin whitener with matrix components that cosmetics skin whitener is normal:
The 1,3- propane diols 2 ~ 10% of 50 ~ 60% glycerine of water 2 ~ 10%
The cetostearyl alcohol ethylhexoate 2 ~ 10% of 0.1 ~ 1% sodium phytate of lecithin 0.02 ~ 0.1%
The Parleam 2 ~ 10% of 0.5 ~ 5% hexyl decyl alcohol of olive oil 2 ~ 10%
The methyl sesquistearate 0.5 ~ 5% of 0.5 ~ 5% tocopherol acetate of docosyl alcohol 0.1 ~ 2%
The dimethyl silicone polymer 0.5 ~ 5% of PEG-20 methyls sesquistearate 0.5 ~ 5%
Acrylic acid (ester) class/aminomethyl propanol 0.1 ~ 1% of C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1 ~ 2%
The bisabolol 0.05 ~ 1% of 0.1 ~ 2% essence of Phenoxyethanol 0.1 ~ 1%.
10. a kind of method of the cosmetics skin whitener prepared described in claim 9, it is characterised in that the method includes following step Suddenly:
1)After water, glycerine, 1,3-PD, lecithin, sodium phytate are uniformly mixed, 75 ~ 80 DEG C are heated with stirring to, at a high speed 10 ~ 30min of homogeneous;
2)By cetostearyl alcohol ethylhexoate, olive oil, hexyl decyl alcohol, Parleam, docosyl alcohol, tocopherol second Acid esters, methyl sesquistearate, PEG-20 methyl sesquistearates are heated with stirring to 75 ~ 80 DEG C, and dissolving is equal It is even;Add dimethyl silicone polymer, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers;
3)By above-mentioned steps 2)Obtained composition adds step 1)In obtained composition, 1 ~ 5min of high speed homogenization adds aminomethyl Propyl alcohol;
4)Stirring is cooled to 40 ~ 45 DEG C, adds Phenoxyethanol, essence, bisabolol, glycyrrhiza glabra root extract, niacinamide, male Red root bark extract and pale flag root extract, stirring are cooled to room temperature.
CN201611129586.7A 2016-12-09 2016-12-09 A kind of cosmetics skin whitener and preparation method thereof Pending CN106726907A (en)

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CN107296764A (en) * 2017-06-28 2017-10-27 深圳市永济泰科技有限公司 Cream and preparation method thereof
CN111297745A (en) * 2019-12-16 2020-06-19 宁波久瑞生物工程有限公司 Absorption-promoting whitening composition and production process and application thereof
CN113332212A (en) * 2021-06-28 2021-09-03 深圳华信健康产业有限公司 Whitening composition and preparation method and application thereof
CN114191344A (en) * 2021-12-19 2022-03-18 苏丽红 Preparation method and processing equipment of cosmetic whitening emulsion for whitening and brightening skin

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