CN111297745A

CN111297745A - Absorption-promoting whitening composition and production process and application thereof

Info

Publication number: CN111297745A
Application number: CN201911300358.5A
Authority: CN
Inventors: 胡建锋; 吴军; 刘冰凌; 黎辉
Original assignee: Ningbo Jiurui Biological Engineering Co ltd
Current assignee: Ningbo Jiurui Biological Engineering Co ltd
Priority date: 2019-12-16
Filing date: 2019-12-16
Publication date: 2020-06-19

Abstract

The invention relates to the field of cosmetics, and discloses a whitening composition for promoting absorption, which comprises the following substances in percentage by mass: 13-35% of humectant, 2-10% of emulsifier, 2-5% of nicotinamide, 0.1-0.5% of thickener, 1-5% of carnosine, 0.05-0.3% of glabridin, 0.3-1.6% of preservative, 1.5-6% of plant extract, 6-16% of fungus fermentation metabolite and the balance of water. The glabridin can penetrate into the skin and keep activity, has the effects of preventing rough skin, resisting bacteria and inflammation, resisting oxidation and ultraviolet rays, whitening and brightening skin, and can achieve the effects of quickly, efficiently, safely and greenly whitening and removing freckles; the fungus fermentation metabolite is added as high-quality yeast essence, contains rich nutrient substances, has the function of nourishing skin, can also strengthen the metabolism of cuticle, can capture free radicals, inhibits the peroxidation of lipid, and has the functions of whitening and resisting aging. The invention also discloses a production process and application of the whitening composition for promoting absorption.

Description

Absorption-promoting whitening composition and production process and application thereof

Technical Field

The invention relates to the field of cosmetics, in particular to a whitening composition for promoting absorption and a production process and application thereof.

Background

There are 3 essential substances necessary for the synthesis of melanin: 1. tyrosine: the main raw material for preparing melanin; 2. tyrosinase, and (c) an enzyme: the major rate-limiting enzyme for the conversion of tyrosine to melanin is a combination of copper and protein; 3. oxygen: tyrosine produces melanin under the action of tyrosinase, an oxidative process that must be combined with oxygen to convert to melanin. The currently accepted synthetic pathway for melanin: tyrosine → dopa → dopaquinone → dopachrome → dihydroxyindole → ketoindole → melanin. Skin whitening agents are substances that act on melanin production and inhibit melanin production during metabolism.

However, most of the existing skin care products are doped with various artificial compounds, such as pigments, essences, preservatives and the like, and the chemical additives can damage skin cells and accelerate skin aging after long-term use. In addition, many skin care products for whitening skin can only cover the skin itself by applying a plurality of thick cosmetic layers on the face, and do not fundamentally inhibit the generation of melanin, thereby failing to thoroughly solve the problems of skin blackening and aging.

Disclosure of Invention

The first purpose of the invention is to provide a whitening composition capable of promoting absorption, so as to realize the effects of whitening and removing freckles quickly, efficiently, safely and greenly.

In order to achieve the above purpose, the basic scheme of the invention is as follows: a whitening composition for promoting absorption comprises the following substances in percentage by mass:

by adopting the technical scheme, the nicotinamide is a derivative of vitamin B3, and can act on the produced melanin, block a melanin transport path and promote the exfoliation of melanin keratinocytes. One of the important ways nicotinamide inhibits the amount of melanin synthesis is that it affects the transport of substances in melanocytes, and that nicotinamide has a regulatory effect on calcium pumps, expression of cellular motor proteins, and melanosome motility in melanocytes.

Carnosine, a dipeptide composed of β -alanine and histidine, is the peptide with the smallest molecules at present, is nontoxic, highly active and easily absorbed by muscles, can effectively resist the generation of free radicals, prevent skin aging, reduce the activity of melanocytes, prevent the activation stage of melanin formation, deeply whiten skin and avoid new spots.

Glabridin is used as a micromolecule natural beauty component with bioactivity, and the main mechanism of skin whitening is as follows: (1) inhibition of the activity of tyrosinase; (2) inhibiting dopamine tautomerase (TRP-2) activity; (3) inhibition of DHICA oxidase activity: (4) act as endothelin antagonists; (5) increase the total antioxidant capacity of the skin; (6) can effectively eliminate oxygen free radicals and chain reaction thereof. Moreover, through the mutual combination and the synergistic effect, the polymerization of 5, 6-Dihydroxyindole (DHI) and the production of dopachrome are effectively prevented and hindered, so that the formation and the transportation of melanin are interfered and prevented, the pigmentation is inhibited and reduced, and the effect of whitening the skin is achieved.

Because human skin has a natural barrier function, active absorption of glabridin by transdermal permeation can be obviously influenced and restricted, so that the biological effect of the glabridin is weakened. In order to effectively improve the effects of the glabridin on skin whitening and anti-aging, the application of the glabridin liposome can optimize the skin whitening effect. The fungus fermentation metabolite is selected as the liposome, which has a similar structure with a biological membrane and a cell membrane, not only can increase the penetration of bioactive substances and functional components into the horny layer of the skin, but also can autonomously complete biodegradation, has no obvious toxicity and no skin irritation, and is an ideal carrier for skin beautifying and local application of cosmetics.

Further, the humectant is one or more of glycerin, isononyl isononanoate, phytosterol oleate and propylene glycol.

By adopting the technical scheme, the glycerol is a thick liquid which is colorless, odorless, sweet, clear and transparent, is internationally recognized as a high-performance humectant, and has globally accepted safety. Glycerol has strong hygroscopicity, and can form a film on skin surface to isolate air and prevent water evaporation, so that skin can not be frostbitten and damaged by dust, and keep soft and elastic.

Because the glycerin belongs to the polyhydric alcohol humectant and has hydroxyl with higher unit density, the hydroxyl in the molecular structure can form hydrogen bonds with water molecules, thereby effectively preventing water evaporation, playing a good role in absorbing and locking water and improving the water content of the skin. When the cosmetic is used, the small molecular polyol structure of the glycerin absorbs moisture from the environment, and can reduce the vapor pressure on the surface of the skin and effectively prevent the moisture from evaporating.

Isononyl isononanoate has a dry and extremely soft hand, is an excellent emollient, and has a low viscosity, a refreshing skin feel, and no greasy feel.

The phytosterol oleate can inhibit polymerization of triglyceride, and has good antioxidant effect.

Propylene glycol has good viscosity and hygroscopicity, and is widely used as a moisture absorbent, an anti-freezing agent, a lubricant and a solvent in the food, pharmaceutical and cosmetic industries; propylene glycol is also used as a solvent and a softener for cosmetics, etc., because it has good miscibility with various perfumes.

Further, the thickener is xanthan gum.

By adopting the technical scheme, the xanthan gum has unique rheological property, good water solubility, stability to heat and acid and alkali, good compatibility with various salts, low-concentration and high-viscosity characteristics (the viscosity of a 1% aqueous solution is 100 times of that of gelatin), and is an efficient thickener.

Further, the emulsifier is one or more of PEG-8C 12-20 acid ester and cetearyl alcohol.

By adopting the technical scheme, the C12-20 acid PEG-8 ester is a nonionic oil-in-water emulsifier, has excellent emulsifying property and good stability, is synthesized by adopting raw materials from plants, is mild and non-irritant to skin, has excellent affinity with the skin, can enable the appearance of a repair cream product to be fine and smooth, and has soft, lasting, lubricating and non-greasy skin feeling in the smearing process.

Cetearyl alcohol is suitable for use in a variety of cosmetic compositions as a base to stabilize and co-emulsify emulsions and to reduce the amount of surfactant required to form a stable emulsion.

Further, the preservative is one or more of ethylhexyl glycerol and phenoxyethanol.

By adopting the technical scheme, the ethylhexyl glycerin is a globally-approved, flexible and multifunctional additive, and is a high-purity, colorless and almost tasteless liquid. It can play a role in inhibiting bacteria in the formula. It can be added to both the aqueous and oil phases. When added into water phase, it can form a bacteriostatic environment, and has antiseptic effect on the whole formula.

Phenoxyethanol is an organic compound frequently used in skin care products, can be synthesized by etherification of ethylene glycol and phenol, and generally plays a role as a preservative in cosmetics, skin care products, vaccines and medicines.

The ethylhexyl glycerin and the phenoxyethanol can be prepared into a complex ligand according to a certain proportion, and the antibacterial performance is gradually increased by reducing the complex ratio of the ethylhexyl glycerin to the phenoxyethanol.

Further, the plant extract is one or more of a peony root extract, a peony root extract and a salvia miltiorrhiza root extract.

By adopting the technical scheme, the paeoniflorin has the advantages that the paeoniflorin has an ultra-strong anti-inflammatory effect, contains abundant classified compounds, is a natural medicinal component, can prevent inflammation in a human body from breeding, can enhance the permeability of capillary vessels of the human body, and can improve the absorption capacity of skin on skin care products. The active ingredients in the peony roots are extracted by an organic solvent method, and the DPPH free radical has higher cleaning capacity; the scavenging capacity of the radix paeoniae extract to DPPH free radicals is gradually enhanced along with the increase of the concentration of the radix paeoniae extract, and the radix paeoniae extract has a good antioxidant effect.

The peony root has analgesic, tranquilizing, antiinflammatory and antipyretic effects; has strong inhibiting effect on various pathogenic bacteria. Active ingredients in peony root bark are extracted by an organic solvent method, and the peony root alcohol extract has good oxidation resistance; when peony extract exists, oxygen ions can be removed, so that the accumulation of melanin intermediate products is prevented.

The Saviae Miltiorrhizae radix has effects of inhibiting or relieving hepatocyte degeneration, necrosis and inflammatory reaction, promoting hepatocyte regeneration, and resisting fibrosis. The active ingredients in the salvia miltiorrhiza root are extracted by an organic solvent method, are easy to be absorbed by human bodies, have obvious antioxidant activity, can clear superoxide anions and hydroxyl free radicals, and inhibit lipid peroxidation.

Further, the fungal fermentation metabolite is one or more of a split yeast fermentation lysate, a lactic acid bacteria fermentation lysate.

By adopting the technical scheme, the lysate of the yeast fermentation product of the second split can generate small molecules which comprise vitamin B group, mineral substances, amino acids and the like and are beneficial to skin care, and the yeast extract is high-quality yeast essence only used for skin care. It has effects in promoting metabolism of stratum corneum, capturing free radicals, inhibiting lipid peroxidation, whitening skin, and resisting aging. The product is rich in nutrients, and has skin nourishing effect.

The lactobacillus fermentation lysate contains thalli and all active ingredients synthesized in the fermentation process, contains peptidoglycan, teichoic acid, protein, phospholipid, sterol, fatty acid, various enzymes, peptide, amino acid, nucleotide, exopolysaccharide and the like, provides rich nutrition for skin, and has good anti-aging effect.

Further, the whitening composition for promoting absorption comprises the following substances in percentage by mass: 1% -8% of glycerol, 8% -12% of isononyl isononanoate, 1% -5% of phytosterol oleate, 1% -5% of PEG-8 ester C12-20, 1% -5% of cetostearyl alcohol, 2% -5% of nicotinamide, 1% -5% of propylene glycol, 0.1% -0.8% of ethylhexylglycerol, 0.1% -0.5% of xanthan gum, 1% -5% of carnosine, 0.05% -0.3% of glabridin, 0.2% -0.8% of phenoxyethanol, 0.5% -2% of peony root extract, 0.5% -2% of salvia root extract, 4% -10% of schizosaccharomyces cerevisiae fermentation product lysate, 2% -6% of lactobacillus fermentation product lysate, The balance being water.

By adopting the technical scheme, the substances with the mass percentage are preferably used as raw materials of the whitening composition for promoting absorption, so that the whitening effect of the skin can be improved to the maximum extent.

In summary, the whitening composition for promoting absorption provided by the invention has the following beneficial effects:

1. glabridin is used as a micromolecule natural beauty component with bioactivity, and the main mechanism of skin whitening is as follows: (1) inhibition of the activity of tyrosinase; (2) inhibiting dopamine tautomerase (TRP-2) activity; (3) inhibition of DHICA oxidase activity: (4) act as endothelin antagonists; (5) increase the total antioxidant capacity of the skin; (6) can effectively eliminate oxygen free radicals and chain reaction thereof. Moreover, through the mutual combination and the synergistic effect, the polymerization of 5, 6-Dihydroxyindole (DHI) and the production of dopachrome are effectively prevented and hindered, so that the formation and the transportation of melanin are interfered and prevented, the pigmentation is inhibited and reduced, and the effect of whitening the skin is achieved.

2. Because human skin has a natural barrier function, active absorption of glabridin by transdermal permeation can be obviously influenced and restricted, so that the biological effect of the glabridin is weakened. In order to effectively improve the effects of the glabridin on skin whitening and anti-aging, the application of the glabridin liposome can optimize the skin whitening effect. The fungus fermentation metabolite is selected as the liposome, which has a similar structure with a biological membrane and a cell membrane, not only can increase the penetration of bioactive substances and functional components into the horny layer of the skin, but also can autonomously complete biodegradation, has no obvious toxicity and no skin irritation, and is an ideal carrier for skin beautifying and local application of cosmetics.

3. One or more of two fungal fermentation metabolites, namely a schizosaccharomyces cerevisiae fermentation product lysate and a lactobacillus fermentation lysate, are added to serve as liposome, glabridin can be encapsulated in the middle of a film formed by lipid bilayer layers to form an ultra-micro spherical carrier preparation, the molecular structure of the glabridin has both hydrophilic groups and hydrophobic groups, and when the glabridin forms a spherical lipid bilayer structure, the glabridin is encapsulated by a structure formed by the hydrophobic groups, so that the glabridin has the advantages of good biocompatibility, high skin absorbability, practicability, safety, low price and the like.

4. The peony root extract, the peony root extract and the salvia miltiorrhiza root extract are used as natural antioxidants and are compounded with carnosine, and the compound agent has a good antioxidant effect and can inhibit the generation of melanin.

The second purpose of the invention is to provide a production process of the whitening composition for promoting absorption, which comprises the following steps:

s1, adding xanthan gum and glycerol into an emulsifying pot and mixing uniformly;

s2, adding water into the emulsifying pot under the stirring state, continuously stirring uniformly, and heating to 80 ℃ for later use;

s3 adding isononyl isononanoate, phytosterol oleate, PEG-8C 12-20 acid ester and cetearyl alcohol into an oil phase pan, heating to 80 ℃, and stirring uniformly;

s4, pumping the oil phase into an emulsifying pot, starting homogenizing for 1min, and cooling to 40 ℃;

s5, mixing glabridin and propylene glycol, stirring and dissolving, adding into an emulsifying pot, and stirring uniformly;

s6 adding yeast secondary fission fermentation lysate, lactobacillus fermentation lysate, carnosine, nicotinamide, radix Paeoniae extract, radix moutan extract, radix Salviae Miltiorrhizae extract, phenoxyethanol, and ethylhexylglycerin, respectively, and stirring.

By adopting the technical scheme, in the step S1, the viscosity of the low-concentration xanthan gum is very high, and the glycerol is used as the polyalcohol to disperse the xanthan gum in the oil phase, so that the viscosity of the xanthan gum is reduced. In step S2, a mixture of xanthan gum and glycerin is added to water, stirred continuously and heated to dissolve the xanthan gum in the oil-in-water emulsion rapidly.

In step S3, isononyl isononanoate, phytosterol oleate, PEG-8C 12-20 acid ester, and cetostearyl alcohol are stirred and mixed in an oil phase pan at 80 ℃ and mixed to form a stable emulsifier.

And S4, mixing the oil-in-water emulsion of xanthan gum with an emulsifier, homogenizing for 1min, and micronizing and homogenizing the dispersion in the emulsion system during homogenization to refine the particles and make the emulsion penetrate into skin surface layer more effectively. This process also serves to both reduce the size of the dispersion and to increase the uniformity of the distribution of the dispersion.

And S5, mixing glabridin and propylene glycol, stirring and dissolving, wherein the propylene glycol has strong solubility on the glabridin, so that the glabridin is uniformly dispersed in an organic solvent of the propylene glycol, and then mixing and stirring the mixed liquid and an emulsion system in an emulsion pot, so that the glabridin is uniformly distributed in the emulsion system.

In the step of S6, the lysate of the yeast fermentation product of the schizosaccharomyces cerevisiae and the lysate of the lactobacillus fermentation product are used as glabridin liposome to be mixed with the emulsion of the glabridin, so that the penetration of the bioactive substances and the functional components of the glabridin into the stratum corneum of the skin can be effectively increased.

Carnosine has similar effect as antioxidant and glabridin, and can further reduce activity of melanocyte by mixing carnosine and glabridin emulsion to generate synergistic effect.

Nicotinamide can act on produced melanin, block melanin transport path, and promote melanocyte desquamation.

The peony root extract, the peony root extract and the salvia miltiorrhiza root extract are used as natural plant extracts, and can effectively permeate into the stratum corneum of the skin by using the schizosaccharomyces cerevisiae fermentation product lysate and the lactobacillus fermentation lysate as carriers to remove oxygen ions, so that the accumulation of melanin intermediate products is prevented.

The phenoxyethanol and the ethylhexyl glycerol are high-quality preservatives, the phenoxyethanol and the ethylhexyl glycerol can be added into a water phase and an oil phase, the phenoxyethanol and the oil phase are prepared into a complex ligand according to a certain proportion, and the smaller the compounding ratio of the ethylhexyl glycerol to the phenoxyethanol is, the stronger the antibacterial performance is. The complex ligand of phenoxyethanol and ethylhexyl glycerol is added, so that a bacteriostatic environment can be formed, and the preservative effect on the whole formula is achieved.

The third purpose of the invention is to provide the application of the whitening composition for promoting absorption: the whitening composition for promoting absorption is used for preparing emulsion cosmetics.

Detailed Description

The present invention will be described in further detail below by way of specific embodiments:

a whitening composition for promoting absorption comprises the following substances in percentage by mass:

1% -8% of glycerol

Isononyl isononanoate 8% -12%

Phytosterol oleate 1% -5%

C12-20 acid PEG-8 ester 1% -5%

Cetearyl alcohol 1% -5%

2 to-5 percent of nicotinamide

1 to 5 percent of propylene glycol

Ethylhexyl glycerin 0.1% -0.8%

Xanthan gum 0.1% -0.5%

Carnosine 1% -5%

Glabridin 0.05-0.3%

0.2 to 0.8 percent of phenoxyethanol

Radix Paeoniae extract 0.5% -2%

Peony root extract 0.5% -2%

Radix Salviae Miltiorrhizae extract 0.5% -2%

The secondary split yeast fermentation product lysate 4% -10%

Lactobacillus fermentation lysate 2% -6%

The balance being water.

The invention is further illustrated by the following examples.

The absorption-promoting whitening compositions of examples 1 to 5 were prepared according to the formulation of table 1

Table 1:

the process for producing the absorption-promoting whitening composition of examples 1 to 5 was prepared as follows:

The whitening composition for promoting absorption of comparative examples 1 to 4 was prepared according to the formulation of table 2

Table 2:

test example one, test of whitening effect of absorption-promoting whitening composition

1. The test substance: examples 1, 2, 3, 4, 5, 1, 2, 3 and 4, and comparative example 1, 2, 3 and 4.

2. A subject:

90 female subjects are selected to participate in the test, the test is 30-50 years old, and the exclusion conditions of the subjects meet the inclusion and exclusion standards of the cosmetic contact dermatitis diagnosis standard and treatment principle.

3. The test method comprises the following steps:

the test site was the inner side of the crank arm, the left and right arms were randomly arranged as test areas, before the test, the MI value of the skin melanin content of the test site of each subject was measured using a skin melanin and heme tester, all the subjects were randomly divided into 9 groups of 10 persons each according to the MI value, the groups were respectively example 1, example 2, example 3, example 4, example 5, comparative example 1, comparative example 2, comparative example 3 and comparative example 4, the absorption-promoting whitening compositions prepared according to example 1, example 2, example 3, example 4, example 5, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 were respectively used, the compositions were applied once in the morning and evening and continuously used for 12 weeks, and no other cosmetic was used at the test site during the test. And testing the MI value of the skin melanin content of the tested part of each tested subject by using a skin melanin and heme tester. The test site is washed before the MI value of the melanin content of the skin is tested.

4. And (3) test results:

the test results are shown in table 3:

table 3:

in examples 1 to 5, glabridin solution, yeast fermentation lysate and lactobacillus fermentation lysate with different proportions were added, only glabridin solution was added in the group of comparative example 1, and neither yeast fermentation lysate nor lactobacillus fermentation lysate was added as glabridin liposome, and it can be seen from table 3 that the skin melanin content MI values of the subjects in the groups of examples 1 to 5 were significantly reduced, and the glabridin permeation effect, the skin whitening effect and the skin whitening effect of glabridin were improved, and the skin whitening effect was optimized by adding yeast fermentation lysate and lactobacillus fermentation lysate as glabridin liposome, compared with the subjects in the group of comparative example 1.

In comparison with the group of the comparative example 2, in which the glabridin solution was added and the fungal fermentation metabolite of the lactobacillus fermentation lysate was added as the glabridin liposome, it can be seen from table 3 that the MI values of the skin melanin contents of the subjects of the groups of examples 1 to 5 were significantly reduced compared with the subjects of the group of the comparative example 2, which indicates that the yeast dehiscence lysate and the lactobacillus fermentation lysate compound solution can more effectively improve the permeation effect of the glabridin on the skin and optimize the skin whitening effect compared with the case that the lactobacillus fermentation lysate is solely used as the glabridin liposome.

In comparison with the test subjects in the comparative example 3, the MI values of the skin melanin contents of the test subjects in the examples 1 to 5 were significantly reduced, which is shown in table 3, by adding the glabridin solution and the yeast fermentation lysate of schizosaccharomyces, which is a fungal fermentation metabolite, as the glabridin liposome, in the comparative example 3, which indicates that the combined solution of the yeast fermentation lysate of schizosaccharomyces and the lactobacillus fermentation lysate can more effectively improve the permeation effect of the glabridin on the skin and optimize the skin whitening effect, compared with the yeast fermentation lysate of schizosaccharomyces, which is solely used as the glabridin liposome.

Compared with the subjects in the group of the comparative example 4, the subjects in the groups of the examples 1 to 5 have obviously reduced MI value of the skin melanin content by adding the glabridin solution, only the schizosaccharomyces cerevisiae fermentation product lysate and the lactobacillus fermentation lysate compound solution, which shows that the glabridin can inhibit the activity of tyrosinase, interfere and prevent the formation and the transportation of melanin, inhibit and reduce the pigmentation, and achieve the effect of whitening the skin.

In summary, compared with the subjects of the comparative example 1, the comparative example 2, the comparative example 3 and the comparative example 4, the MI values of the skin melanin contents of the subjects of the examples 1 to 5 were significantly reduced, which indicates that the absorption-promoting whitening compositions obtained in the examples 1 to 5 of the present invention can significantly reduce the MI values of the skin melanin contents, and the absorption-promoting whitening compositions provided by the present invention have significant whitening effects.

Test example two, test of antioxidant effect of absorption-promoting whitening composition

The antioxidant effect is shown by measuring DPPH free radical clearance rate of the whitening composition for promoting absorption.

2. The determination method comprises the following steps: 4mL of the solution was added at a concentration of 6X 10^-5mol/L of DPPH solution was added to 5mL of the absorption promoting whitening composition prepared in examples 1 to 6 and comparative examples 1 to 4, respectively, well mixed and left in a water bath at 37 ℃ for 1 hour, and then the absorbance value of the solution at a detection wavelength of 500nm was measured as A0, and 4mL of DPPCH was taken and 0.1mL of ethanol was added thereto, and the absorbance value at the same wavelength was measured as Ai, and the removal rate K ═ A0)/Ai × 100%.

3. And (3) test results:

the test results are shown in table 4.

Table 4: measurement of DPPH radical clearance rate of absorption-promoting whitening composition:

in the examples 1 to 5, glabridin solution, yeast bifida lysate and lactobacillus fermentation lysate with different proportions are added, only glabridin solution is added in the group of the comparative example 1, and no yeast bifida lysate or lactobacillus fermentation lysate is added as glabridin liposome, and it can be seen from table 4 that compared with the subjects in the group of the comparative example 1, the whitening composition for promoting absorption, prepared in the examples 1 to 5, can effectively remove DPPH free radicals, and the yeast bifida lysate and lactobacillus fermentation lysate are added as glabridin liposome, so that the permeation effect of glabridin on the skin can be improved, the efficacy of glabridin on the anti-oxidation aspect can be effectively improved, and the anti-aging effect of the skin can be optimized.

As shown in table 4, compared with the subjects in the comparative example 2, the whitening compositions for promoting absorption prepared in examples 1 to 5 can effectively remove DPPH free radicals, which indicates that the dicrotic yeast fermentation lysate and the lactic acid bacteria fermentation lysate compound solution can improve the permeation effect of glabridin on the skin, effectively improve the efficacy of glabridin in the aspect of oxidation resistance, and optimize the anti-aging effect of the skin, compared with the lactic acid bacteria fermentation lysate which is solely used as glabridin liposome, compared with the lactobacillus fermentation lysate prepared in the comparative example 2.

In comparison with the subjects in comparison example 3, it can be seen from table 4 that the absorption-promoting whitening compositions prepared in examples 1 to 5 can effectively remove DPPH free radicals, which indicates that the diclazaromyces fermentation lysate and lactobacillus fermentation lysate compound solution can improve the permeation effect of glabridin on skin, effectively improve the efficacy of glabridin in oxidation resistance, and optimize the anti-aging effect of skin, compared with the lactobacillus fermentation lysate alone serving as glabridin liposome.

As can be seen from table 4, compared with the subjects in the comparative example 4, the absorption-promoting whitening compositions prepared in examples 1 to 5 can effectively remove DPPH radicals, and the glabridin can inhibit the activity of oxidase, has significant efficacy in oxidation resistance, and can improve the anti-aging effect of skin.

In summary, compared with the subjects of comparative example 1, comparative example 2, comparative example 3 and comparative example 4, the absorption-promoting whitening compositions prepared in examples 1 to 5 of the present invention can effectively scavenge DPPH radicals, which indicates that the absorption-promoting whitening compositions provided by the present invention have a very good anti-aging effect.

The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims

1. A whitening composition that promotes absorption characterized by: the material comprises the following substances in percentage by mass:

2. the absorption enhancing whitening composition of claim 1, wherein: the humectant is one or more of glycerol, isononyl isononanoate, phytosterol oleate and propylene glycol.

3. The absorption enhancing whitening composition of claim 2, wherein: the emulsifier is one or more of PEG-8 ester C12-20 acid and cetearyl alcohol.

4. The absorption enhancing whitening composition of claim 3, wherein: the thickening agent is xanthan gum.

5. The absorption enhancing whitening composition of claim 4, wherein: the preservative is one or more of ethylhexyl glycerol and phenoxyethanol.

6. The absorption enhancing whitening composition of claim 5, wherein: the plant extract is one or more of radix Paeoniae extract, radix moutan extract, and radix Salviae Miltiorrhizae extract.

7. The absorption enhancing whitening composition of claim 6, wherein: the fungus fermentation metabolite is one or more of a schizosaccharomyces cerevisiae fermentation lysate and a lactobacillus fermentation lysate.

8. The absorption enhancing whitening composition of claim 7, wherein: the material comprises the following substances in percentage by mass: 1% -8% of glycerol, 8% -12% of isononyl isononanoate, 1% -5% of phytosterol oleate, 1% -5% of PEG-8 ester C12-20, 1% -5% of cetostearyl alcohol, 2% -5% of nicotinamide, 1% -5% of propylene glycol, 0.1% -0.8% of ethylhexylglycerol, 0.1% -0.5% of xanthan gum, 1% -5% of carnosine, 0.05% -0.3% of glabridin, 0.2% -0.8% of phenoxyethanol, 0.5% -2% of peony root extract, 0.5% -2% of salvia root extract, 4% -10% of schizosaccharomyces cerevisiae fermentation product lysate, 2% -6% of lactobacillus fermentation product lysate, The balance being water.

9. A production process of a whitening composition for promoting absorption is characterized in that: the method comprises the following steps:

10. Use of an absorption enhancing whitening composition according to any of claims 1 to 9, characterized in that: the whitening composition for promoting absorption is used for preparing emulsion cosmetics.