CN112587456A - Repairing and whitening composition and preparation method thereof - Google Patents
Repairing and whitening composition and preparation method thereof Download PDFInfo
- Publication number
- CN112587456A CN112587456A CN202011567656.3A CN202011567656A CN112587456A CN 112587456 A CN112587456 A CN 112587456A CN 202011567656 A CN202011567656 A CN 202011567656A CN 112587456 A CN112587456 A CN 112587456A
- Authority
- CN
- China
- Prior art keywords
- whitening composition
- repairing
- whitening
- mixture
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a repairing and whitening composition and a preparation method thereof; contains acetyl chitosamine, glabridin, hydrogenated lecithin, butyl methoxyl dibenzoyl methane, tocopherol, piperine, dipotassium glycyrrhizinate, methoxyl potassium salicylate, tranexamic acid, alpha arbutin, nicotinamide, herba Camelliae Japonicae extract, and 3-O-ethyl ascorbic acid; according to the whitening action mechanism, the whitening effect is enhanced by directional multi-target multi-path, wherein the butyl methoxy dibenzoyl methane resists the damage of ultraviolet rays; dipotassium glycyrrhizinate and acetyl chitosamine can reduce inflammation and ultraviolet stimulation; arbutin and glabridin inhibit tyrosinase activity; tocopherol inhibits the oxidation of tyrosine to dopa; 3-o-ethyl ascorbic acid reduces dopaquinone to dopa; glabridin inhibits dopachrome tautomerase activity and DHICA oxidase activity; tranexamic acid, nicotinamide inhibit melanin transport; niacinamide and 4-methoxy potassium salicylate promote epidermis renewal; the eight targets act together and coordinate with each other to exert the whitening effect.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a repairing and whitening composition and a preparation method thereof.
Background
This is particularly influenced by cultural impacts (which occur mostly in Asian countries) due to the increasing pigmentation found in skin disorders and the psycho-social and cosmetic negative effects of excessive pigmentation. With the continuous improvement of living standard, people are pursuing healthy and white skin, so that the demand of whitening compositions is increasing.
Meanwhile, the types of the whitening cosmetics on the market are more and more, the phenomenon that the whitening products on the market are unsmooth is caused, and most products on the market achieve the effects of whitening and brightening the skin through single ways of inhibiting tyrosinase activity, removing oxygen radicals and the like. However, the effect of the single whitening principle is limited.
Through the search of the existing patent documents, the Chinese invention patent application CN 109662904A discloses a composition with whitening and antioxidant effects, and an application and a preparation method thereof. The composition comprises 0.1 to 3.0 weight parts of water containing factor; 0.01-0.5 parts by weight of polymerization anti-sensitivity factor; 0.1-1.0 weight part of centella asiatica extract; 0.1-3.0 parts by weight of nicotinamide; 0.01-0.3 weight part of alpha-arbutin; 0.1-3.0 parts by weight of tranexamic acid; 0.01-0.1 part by weight of chamomile extract; 0.1-1.0 part by weight of ellagic acid; 0.1-3.0 parts by weight of plant whitening extract; 0.1-0.5 parts by weight of acetylcysteine; 1.0-5.0 parts by weight of hydrolyzed yeast protein; 0.1-3.0 parts by weight of glycosaminoglycan; 0.01-0.1 weight part of aloe extract; 0.1-3.0 parts by weight of green alga extract; 20.1 to 1.0 weight portion of hexapeptide; 0.01-0.5 weight portion of sodium hyaluronate and the like. The invention utilizes different medicinal mechanisms of each component, fully exerts the synergistic interaction effect of each component, and ensures that the obtained composition can accelerate cell metabolism, capture free radicals, inhibit lipid peroxidation, block melanocyte channels, accelerate the falling of melanocytes and the like. However, effective whitening is achieved, the functional components must act on basal melanocytes, and the functional components of the common preparation formulation are difficult to enter whitening target sites. And part of the effective components have irritation to the skin, and the effective active components are easy to generate instability and lose activity.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a repairing and whitening composition and a preparation method thereof. The repairing and whitening composition disclosed by the invention plays a role by adopting a multi-target whitening mechanism, and has a remarkable whitening and skin brightening effect.
The purpose of the invention is realized by the following technical scheme:
the invention provides a repairing and whitening composition, which comprises the following components in percentage by weight:
as one embodiment of the invention, the composition comprises the following components in percentage by weight:
as an embodiment of the invention, the camellia extract adopts 'Qingxuan extract' purchased from Anji Linqingxuan agricultural science and technology Limited.
In one embodiment of the invention, the preferred dosage ratio of glabridin to tocopherol to 3-o-ethyl ascorbic acid in the composition is 1: 0.1-1. In the composition system of the present invention, 8 targets act together; wherein arbutin and glabridin can effectively inhibit tyrosinase activity; tocopherol inhibits the oxidation of tyrosine to dopa; the 3-o-ethyl ascorbic acid derivative can reduce the dopaquinone into dopa; glabridin can inhibit activity of dopachrome tautomerase and activity of DHICA oxidase. The invention discovers that the four target points can play the best synergistic action to achieve the best whitening effect when the dosage of the glabridin, the tocopherol and the 3-o-ethyl ascorbic acid is within the range.
The invention also relates to a preparation method of the repairing and whitening composition, which comprises the following steps:
s1, adding the butyl methoxy dibenzoyl methane, the tocopherol/vitamin E and the camellia extract into an oil phase preparation pot, heating to 75-85 ℃, and uniformly stirring to obtain a mixture A;
s2, sequentially adding the glabridin, the piperine, the hydrogenated lecithin, the 4-methoxy potassium salicylate and the 1, 3-butanediol into an emulsifying preparation pot, heating to 75-85 ℃, and completely dissolving to obtain a mixture B;
s3, mixing and stirring the water, the acetyl chitosamine, the dipotassium glycyrrhizinate, the tranexamic acid, the alpha arbutin, the nicotinamide and the 3-o-ethyl ascorbic acid uniformly in advance for later use to obtain a mixture C;
s4, adding the mixture A into the mixture B at 75-85 ℃, and uniformly mixing and stirring;
s5, cooling to 45-55 ℃, adding the mixture C into the mixture obtained in the step S4, and uniformly stirring;
s6, cooling to 38-40 ℃, and discharging to obtain the composition.
In an embodiment of the present invention, step S4 further includes a step of homogenizing at a high speed for 3 to 8 minutes before the mixing and stirring are performed uniformly.
In an embodiment of the present invention, step S5 includes a step of homogenizing at a high speed for 2 to 5 minutes before homogenizing.
As an embodiment of the present invention, the high speed uniform rate is 2000-4000 rpm. As a specific example, the high speed uniform rate is 3000 rpm.
As an embodiment of the invention, the step S6 further comprises a step of taking material for detection, and filtering and discharging the material through 400-mesh filter cloth and 500-mesh filter cloth after the material is qualified.
Compared with the prior art, the invention has the following beneficial effects:
1. the whitening composition provided by the invention has the advantages that the whitening effect is enhanced in multiple ways by orienting multiple targets according to the whitening action mechanism, wherein the butyl methoxydibenzoylmethane resists the damage of ultraviolet UVA and UVB; dipotassium glycyrrhizinate, acetyl chitosamine and the like can effectively reduce inflammation and ultraviolet stimulation; arbutin and glabridin can effectively inhibit the activity of tyrosinase; tocopherol inhibits the oxidation of tyrosine to dopa; 3-o-ethyl ascorbic acid can reduce dopaquinone to dopa; glabridin can inhibit activity of dopachrome tautomerase and activity of DHICA oxidase; tranexamic acid, nicotinamide, inhibits the transport of melanin; nicotinamide and 4-methoxy potassium salicylate can accelerate cutin shedding and promote epidermis regeneration; the 8 target spots act together to coordinate with each other to play the whitening effect of the repairing and whitening composition and brighten the skin color;
2. the formula of the composition is designed according to a whitening mechanism, so that the composition is more scientific and reasonable; meanwhile, the addition of the hydrogenated lecithin and the tetrahydropiperine can protect better penetration and absorption of active ingredients and eliminate irritation to the epidermis, and the addition of the camellia extract can effectively repair skin barriers;
3. the composition has hydrophilic and lipophilic characteristics similar to the structure of skin cell membranes, so that the composition can permeate the skin to realize that multifunctional multi-target functional components enter a whitening target part.
4. The composition of the invention utilizes advanced liposome encapsulation technology, can effectively reduce the irritation to the skin, can improve the stability of the functional components, and enables the functional components to achieve the effect of slow release and long acting.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
The camellia extracts described below are all prepared from Qingxuan extract purchased from Anji Linqingxuan agricultural science and technology Limited.
The preparation method of the following composition comprises the following steps:
s1, adding butyl methoxy dibenzoyl methane, tocopherol (vitamin E) and QINGXUAN extract into an oil phase preparation pot, heating to 80 ℃, and uniformly stirring to obtain a mixture A;
s2, sequentially adding glabridin, piperine, hydrogenated lecithin, 4-methoxy potassium salicylate and 1, 3-butanediol into an emulsifying preparation pot, heating to 80 ℃, and completely dissolving to obtain a mixture B;
s3, mixing and stirring water, acetyl chitosamine, dipotassium glycyrrhizinate, tranexamic acid, alpha arbutin, nicotinamide and 3-o-ethyl ascorbic acid uniformly in advance for later use to obtain a mixture C;
s4, adding the mixture A into the mixture B at 80 ℃, uniformly mixing at a high speed for 5 minutes, and uniformly mixing and stirring;
s5, cooling to 50 ℃, adding the mixture C into an emulsification preparation pot, uniformly stirring at a high speed for 3 minutes, and uniformly stirring;
s6, cooling to 39 ℃, taking the materials, detecting, filtering with 500-mesh filter cloth after the materials are qualified, and discharging to obtain the composition.
Example 1
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 2
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 3
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 4
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 5
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 6
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 1
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 2
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 3
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 4
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 5
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 6
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
effect verification 1: safety test
The whitening compositions prepared in all the examples and comparative examples were subjected to a human body safety patch test, which was referred to the human body skin patch test in 2015 cosmetic safety specifications. The method for the skin closed patch test comprises the following steps: selecting 30 persons with age of 18-60 years, selecting the persons with area not more than 50mm2And a qualified spot test device with a depth of about 1mm, 20mg of the repairing and whitening composition prepared in the above examples and comparative examples was placed in a spot test device chamber, a control hole was blank (no substance was placed), the spot test device with the repairing and whitening composition added was applied to the curved side of the forearm of the subject, and the patch was uniformly applied to the skin by gentle pressure of the palm for 24 hours. The skin reactions were observed according to the standard of table 1 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque tester containing the repairing and whitening composition, respectively, and the observation results were recorded. The patch test results for the repair and whitening composition are shown in table 2.
The experimental results show that the repairing and whitening compositions prepared in all the examples and comparative examples pass the safety test of the human body patch.
TABLE 1 skin closed Patch test skin response grading Standard
TABLE 2 human body safety test results
Sample numbering | 30min | 24h | 48h | Total result |
Example 1 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 2 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 3 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 4 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 5 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 6 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 1 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 2 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 3 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 4 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 5 | 0 | 0 | 0 | No positive reaction for 30 people |
Effect verification 2: determination of melanin
Use ofTesting the melanin content of the skin of the tested area by using MX18 probe for three times, and taking an average value
And (4) judging a result: after the product is used for 0 day, 14 days and 28 days, the MI value of the tested area is obviously reduced compared with that of the blank area, and the tested sample has the whitening effect. As can be seen from table 3, the examples are significantly different from the comparative examples, and under the same conditions, the whitening composition of the present invention can effectively reduce the melanin content of the skin.
TABLE 3
Effect verification 3: skin color (L and ITA) determination
Skin color (L and ITA) was tested three times using the Skin-Colorimeter CL 400 probe, and averaged.
And (4) judging a result: after the product is used for 7 days and 14 days, the L value or the ITA value of the test area is obviously increased compared with that of the blank area, and the test sample has the whitening effect. As can be seen from tables 4 and 5, the examples and the comparative examples are significantly different, and under the same conditions, the whitening composition of the present invention can significantly improve the L value and ITA of the skin, and effectively increase the whiteness of the skin.
TABLE 4
TABLE 5
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (9)
3. the repair whitening composition of claim 1, wherein the camellia extract is a "Qingxuan extract" available from Anjilinqingxuan agricultural science, ltd.
4. The repairing and whitening composition according to claim 1, wherein the composition comprises glabridin, tocopherol and 3-o-ethyl ascorbic acid in an amount ratio of 1: 0.1-1.
5. A method of preparing the repair and whitening composition according to any one of claims 1 to 4, characterized in that the method comprises the steps of:
s1, adding the butyl methoxy dibenzoyl methane, the tocopherol/vitamin E and the camellia extract into an oil phase preparation pot, heating to 75-85 ℃, and uniformly stirring to obtain a mixture A;
s2, sequentially adding the glabridin, the piperine, the hydrogenated lecithin, the 4-methoxy potassium salicylate and the 1, 3-butanediol into an emulsifying preparation pot, heating to 75-85 ℃, and completely dissolving to obtain a mixture B;
s3, mixing and stirring the water, the acetyl chitosamine, the dipotassium glycyrrhizinate, the tranexamic acid, the alpha arbutin, the nicotinamide and the 3-o-ethyl ascorbic acid uniformly in advance for later use to obtain a mixture C;
s4, adding the mixture A into the mixture B at 75-85 ℃, and uniformly mixing and stirring;
s5, cooling to 45-55 ℃, adding the mixture C into the mixture obtained in the step S4, and uniformly stirring;
s6, cooling to 38-40 ℃, and discharging to obtain the composition.
6. The preparation method of the repairing and whitening composition of claim 5, wherein the step of homogenizing at a high speed for 3-8 minutes is further included before the mixing and stirring are performed uniformly in the step S4.
7. The preparation method of the repairing and whitening composition of claim 5, further comprising a step of homogenizing at a high speed for 2-5 minutes before homogenizing in step S5.
8. The method of preparing the repair and whitening composition of claim 6 or 7, wherein the high speed uniform rate is 2000-4000 rpm.
9. The preparation method of the repairing and whitening composition as claimed in claim 5, wherein the step S6 further comprises the steps of taking material, detecting, filtering with 400-mesh and 500-mesh filter cloth after passing the material, and discharging.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011567656.3A CN112587456B (en) | 2020-12-25 | 2020-12-25 | Repairing and whitening composition and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011567656.3A CN112587456B (en) | 2020-12-25 | 2020-12-25 | Repairing and whitening composition and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112587456A true CN112587456A (en) | 2021-04-02 |
CN112587456B CN112587456B (en) | 2023-04-07 |
Family
ID=75202181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011567656.3A Active CN112587456B (en) | 2020-12-25 | 2020-12-25 | Repairing and whitening composition and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112587456B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113197811A (en) * | 2021-05-27 | 2021-08-03 | 广州市南方医康生物科技有限公司 | Cosmetic with whitening and freckle removing effects and preparation method thereof |
CN115337235A (en) * | 2022-07-25 | 2022-11-15 | 上海林清轩生物科技有限公司 | Multi-whitening-path composition containing camellia chrysantha extract |
CN115670990A (en) * | 2021-12-29 | 2023-02-03 | 上海优萃生物科技有限公司 | Whitening composition and preparation method and application thereof |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104971029A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Whitening mask and preparation method thereof |
CN106580792A (en) * | 2016-12-24 | 2017-04-26 | 严志海 | Whitening facial cream and preparation method thereof |
CN109106677A (en) * | 2018-09-30 | 2019-01-01 | 江门职业技术学院 | A kind of composition and its application with whitening function |
CN109288715A (en) * | 2018-11-27 | 2019-02-01 | 黄犟兵 | A kind of whitening remediation composition and preparation method thereof |
CN110559243A (en) * | 2019-09-26 | 2019-12-13 | 上海清轩生物科技有限公司 | repairing and whitening composition containing camellia extract and microcapsule prepared from repairing and whitening composition |
CN110721104A (en) * | 2019-10-31 | 2020-01-24 | 泉后(广州)生物科技研究院有限公司 | Whitening cream and preparation method thereof |
CN110840799A (en) * | 2019-10-18 | 2020-02-28 | 广州熠辉生物科技有限公司 | Whitening, moisturizing, antibacterial and mosquito-repellent body lotion and preparation method thereof |
CN111297745A (en) * | 2019-12-16 | 2020-06-19 | 宁波久瑞生物工程有限公司 | Absorption-promoting whitening composition and production process and application thereof |
CN111450008A (en) * | 2020-04-30 | 2020-07-28 | 广州天玺生物科技有限公司 | Whitening cream and preparation method thereof |
-
2020
- 2020-12-25 CN CN202011567656.3A patent/CN112587456B/en active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104971029A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Whitening mask and preparation method thereof |
CN106580792A (en) * | 2016-12-24 | 2017-04-26 | 严志海 | Whitening facial cream and preparation method thereof |
CN109106677A (en) * | 2018-09-30 | 2019-01-01 | 江门职业技术学院 | A kind of composition and its application with whitening function |
CN109288715A (en) * | 2018-11-27 | 2019-02-01 | 黄犟兵 | A kind of whitening remediation composition and preparation method thereof |
CN110559243A (en) * | 2019-09-26 | 2019-12-13 | 上海清轩生物科技有限公司 | repairing and whitening composition containing camellia extract and microcapsule prepared from repairing and whitening composition |
CN110840799A (en) * | 2019-10-18 | 2020-02-28 | 广州熠辉生物科技有限公司 | Whitening, moisturizing, antibacterial and mosquito-repellent body lotion and preparation method thereof |
CN110721104A (en) * | 2019-10-31 | 2020-01-24 | 泉后(广州)生物科技研究院有限公司 | Whitening cream and preparation method thereof |
CN111297745A (en) * | 2019-12-16 | 2020-06-19 | 宁波久瑞生物工程有限公司 | Absorption-promoting whitening composition and production process and application thereof |
CN111450008A (en) * | 2020-04-30 | 2020-07-28 | 广州天玺生物科技有限公司 | Whitening cream and preparation method thereof |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113197811A (en) * | 2021-05-27 | 2021-08-03 | 广州市南方医康生物科技有限公司 | Cosmetic with whitening and freckle removing effects and preparation method thereof |
CN115670990A (en) * | 2021-12-29 | 2023-02-03 | 上海优萃生物科技有限公司 | Whitening composition and preparation method and application thereof |
CN115337235A (en) * | 2022-07-25 | 2022-11-15 | 上海林清轩生物科技有限公司 | Multi-whitening-path composition containing camellia chrysantha extract |
CN115337235B (en) * | 2022-07-25 | 2023-06-13 | 上海林清轩生物科技有限公司 | Multiple whitening pathway composition containing safflower camellia extract |
Also Published As
Publication number | Publication date |
---|---|
CN112587456B (en) | 2023-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112587456B (en) | Repairing and whitening composition and preparation method thereof | |
CA2749750C (en) | Skin care compositions and methods of use thereof | |
EP2521528B1 (en) | Use of at least one extract of flowers of camellia japonica alba plena for moisturizing the skin | |
CN110731924A (en) | Enhanced anti-aging cosmetic compositions | |
US10532023B2 (en) | Camellia japonica extract and cosmetic compositions containing same | |
CN112618400A (en) | Composition for improving skin color and whitening cosmetic | |
WO2021031750A1 (en) | Mixed birch sap and application thereof in skin care cosmetic composition | |
CN109288715A (en) | A kind of whitening remediation composition and preparation method thereof | |
CN106309154A (en) | Skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate | |
CA3062635A1 (en) | Topical muscadine formulation for cosmetic use | |
CN110859797A (en) | Cosmetic composition containing simons extract and edelweiss cells and application | |
CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
CN109350579B (en) | Whitening cosmetic additive, whitening skin-refreshing lotion and preparation method thereof | |
EP2588062B1 (en) | Use of tiliacora triandra in cosmetics and compositions thereof | |
US10149817B2 (en) | Topical skin treatment composition comprising dendranthema indicum extract | |
CN114588061A (en) | Anti-aging and wrinkle-removing composition, preparation method thereof and skin care product | |
CN113893191A (en) | Whitening essence based on phospholipid-coated glabridin nanoemulsion and preparation method thereof | |
CN112933011A (en) | Whitening composition and preparation process and application thereof | |
CN109453088B (en) | Whitening and firming cream, preparation method thereof and tyrosinase inhibitor | |
JP5117092B2 (en) | Moisturizer, anti-aging agent, whitening agent, antioxidant, slimming agent, treatment agent, arginase activity promoter and external preparation for skin | |
CN115869233A (en) | Whitening and anti-wrinkle essence and preparation method thereof | |
CN111743798B (en) | Multi-effect anti-aging skin care product and preparation method thereof | |
KR101154772B1 (en) | Cosmetic composition containing the zizyphus jujuba fruit extract and walnut extract for moisturizing effect on the skin | |
CN113876626A (en) | Composition with protective effect on skin cell damage induced by blue light and application of composition in cosmetics | |
CN116115540B (en) | Skin anti-aging composition, application and daily chemical product |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |