CN112587456B - Repairing and whitening composition and preparation method thereof - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a repairing and whitening composition and a preparation method thereof; contains acetyl chitosamine, glabridin, hydrogenated lecithin, butyl methoxyl dibenzoyl methane, tocopherol, piperine, dipotassium glycyrrhizinate, potassium methoxysalicylate, tranexamic acid, alpha arbutin, nicotinamide, camellia japonica extract, and 3-o-ethyl ascorbic acid; according to the whitening action mechanism, the whitening effect is enhanced by orienting multiple targets and multiple paths, wherein the butyl methoxy dibenzoyl methane resists the damage of ultraviolet rays; dipotassium glycyrrhizinate and acetyl chitosamine can reduce inflammation and ultraviolet stimulation; arbutin and glabridin inhibit tyrosinase activity; tocopherol inhibits the oxidation of tyrosine to dopa; 3-o-ethyl ascorbic acid reduces dopaquinone to dopa; glabridin inhibits dopachrome tautomerase activity and DHICA oxidase activity; tranexamic acid, nicotinamide inhibit melanin transport; the nicotinamide and the 4-methoxy potassium salicylate promote the renewal of epidermis; the eight targets act together and coordinate with each other to exert the whitening effect.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a repairing and whitening composition and a preparation method thereof.
Background
This is particularly influenced by cultural impacts (which occur mostly in Asian countries) due to the increasing pigmentation found in skin disorders and the psycho-social and cosmetic negative effects of excessive pigmentation. With the continuous improvement of living standard, people are pursuing healthy and white skin, so that the demand of whitening compositions is increasing.
Meanwhile, the types of the whitening cosmetics on the market are more and more, the phenomenon that the whitening products on the market are unsmooth is caused, and most products on the market achieve the effects of whitening and brightening the skin through single ways of inhibiting tyrosinase activity, removing oxygen radicals and the like. However, the single whitening principle has limited effect.
Through the search of the existing patent documents, the Chinese invention patent application CN 109662904A discloses a composition with whitening and antioxidant effects, and an application and a preparation method thereof. The composition comprises 0.1 to 3.0 weight parts of water containing factor; 0.01-0.5 parts by weight of polymerization anti-sensitivity factor; 0.1-1.0 weight part of centella asiatica extract; 0.1-3.0 parts by weight of nicotinamide; 0.01-0.3 weight part of alpha-arbutin; 0.1-3.0 parts by weight of tranexamic acid; 0.01-0.1 part by weight of chamomile extract; 0.1-1.0 part by weight of ellagic acid; 0.1-3.0 parts by weight of plant whitening extract; 0.1-0.5 parts by weight of acetylcysteine; 1.0-5.0 parts by weight of hydrolyzed yeast protein; 0.1-3.0 parts by weight of glycosaminoglycan; 0.01-0.1 weight part of aloe extract; 0.1-3.0 parts by weight of green alga extract; hexapeptide-2.1-1.0 weight parts; 0.01-0.5 weight portion of sodium hyaluronate and the like. The invention utilizes different medicinal mechanisms of each component, fully exerts the synergistic interaction effect of each component, and ensures that the obtained composition can accelerate cell metabolism, capture free radicals, inhibit lipid peroxidation, block melanocyte channels, accelerate the falling of melanocytes and the like. However, effective whitening is achieved, the functional components must act on basal melanocytes, and the functional components of the common preparation formulation are difficult to enter whitening target sites. And part of the effective components have irritation to the skin, and the effective active components are easy to generate instability and lose activity.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a repairing and whitening composition and a preparation method thereof. The repairing and whitening composition disclosed by the invention plays a role by adopting a multi-target whitening mechanism, and has a remarkable whitening and skin brightening effect.
The purpose of the invention is realized by the following technical scheme:
the invention provides a repairing and whitening composition, which comprises the following components in percentage by weight:
as one embodiment of the invention, the composition comprises the following components in percentage by weight:
as an embodiment of the invention, the camellia extract adopts 'Qingxuan extract' purchased from Anji Linqingxuan agricultural science and technology Limited.
As an embodiment of the present invention, in the composition, glabridin, tocopherol and 3-o-ethyl ascorbic acid are preferably used in a ratio of 1. In the composition system of the present invention, 8 targets act together; wherein arbutin and glabridin can effectively inhibit tyrosinase activity; tocopherol inhibits the oxidation of tyrosine to dopa; the 3-o-ethyl ascorbic acid derivative can reduce the dopaquinone into dopa; glabridin can inhibit activity of dopachrome tautomerase and DHICA oxidase. The invention discovers that the four target points can play the best synergistic action to achieve the best whitening effect when the dosage of the glabridin, the tocopherol and the 3-o-ethyl ascorbic acid is in the range.
The invention also relates to a preparation method of the repairing and whitening composition, which comprises the following steps:
s1, adding the butyl methoxy dibenzoyl methane, the tocopherol/vitamin E and the camellia extract into an oil phase preparation pot, heating to 75-85 ℃, and uniformly stirring to obtain a mixture A;
s2, sequentially adding the glabridin, the piperine, the hydrogenated lecithin, the 4-methoxy potassium salicylate and the 1, 3-butanediol into an emulsifying preparation pot, heating to 75-85 ℃, and completely dissolving to obtain a mixture B;
s3, mixing and stirring the water, the acetyl chitosamine, the dipotassium glycyrrhizinate, the tranexamic acid, the alpha arbutin, the nicotinamide and the 3-o-ethyl ascorbic acid uniformly in advance for later use to obtain a mixture C;
s4, adding the mixture A into the mixture B at 75-85 ℃, and uniformly mixing and stirring;
s5, cooling to 45-55 ℃, adding the mixture C into the mixture obtained in the step S4, and uniformly stirring;
s6, cooling to 38-40 ℃, and discharging to obtain the composition.
In one embodiment of the present invention, step S4 further comprises a step of homogenizing at a high speed for 3 to 8 minutes before the mixing and stirring are performed uniformly.
In one embodiment of the present invention, step S5 further comprises a step of homogenizing at a high speed for 2 to 5 minutes before homogenizing.
As an embodiment of the present invention, the high speed uniform rate is 2000-4000rpm. As a specific example, the high speed uniform rate is 3000rpm.
As an embodiment of the invention, the step S6 also comprises the steps of taking materials, detecting, filtering with 400-500-mesh filter cloth after the materials are qualified, and discharging.
Compared with the prior art, the invention has the following beneficial effects:
1. the whitening composition provided by the invention has the advantages that the whitening effect is enhanced in multiple ways by orienting multiple targets according to the whitening action mechanism, wherein the butyl methoxydibenzoylmethane resists the damage of ultraviolet UVA and UVB; dipotassium glycyrrhizinate, acetyl chitosamine and the like can effectively reduce inflammation and ultraviolet stimulation; arbutin and glabridin can effectively inhibit tyrosinase activity; tocopherol inhibits the oxidation of tyrosine to dopa; 3-o-ethyl ascorbic acid can reduce dopaquinone to dopa; glabridin can inhibit activity of dopachrome tautomerase and activity of DHICA oxidase; tranexamic acid, nicotinamide, inhibits the transport of melanin; nicotinamide and 4-methoxy potassium salicylate can accelerate cutin shedding and promote epidermis regeneration; the 8 targets act together, and the whitening effect of the repairing and whitening composition is cooperatively exerted, so that the skin color is brightened;
2. the formula of the composition is designed according to a whitening mechanism, so that the composition is more scientific and reasonable; meanwhile, the addition of the hydrogenated lecithin and the tetrahydropiperine can protect better penetration and absorption of active ingredients and eliminate irritation to the epidermis, and the addition of the camellia extract can effectively repair skin barriers;
3. the composition has hydrophilic and lipophilic characteristics similar to the structure of a skin cell membrane, so that the composition can penetrate through the skin to realize that multifunctional multi-target functional components enter a whitening target part.
4. The composition of the invention utilizes advanced liposome encapsulation technology, can effectively reduce the irritation to the skin, can improve the stability of the functional components, and enables the functional components to achieve the effect of slow release and long acting.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
The camellia extracts described below are all prepared from Qingxuan extract purchased from Anji Linqingxuan agricultural science and technology Limited.
The preparation method of the following composition comprises the following steps:
s1, adding butyl methoxy dibenzoyl methane, tocopherol (vitamin E) and Qingxuan extract into an oil phase preparation pot, heating to 80 ℃, and uniformly stirring to obtain a mixture A;
s2, sequentially adding glabridin, piperine, hydrogenated lecithin, 4-methoxy potassium salicylate and 1, 3-butanediol into an emulsifying preparation pot, heating to 80 ℃, and completely dissolving to obtain a mixture B;
s3, mixing and stirring water, acetyl chitosamine, dipotassium glycyrrhizinate, tranexamic acid, alpha arbutin, nicotinamide and 3-o-ethyl ascorbic acid uniformly in advance for later use to obtain a mixture C;
s4, adding the mixture A into the mixture B at 80 ℃, uniformly mixing at a high speed for 5 minutes, and uniformly mixing and stirring;
s5, cooling to 50 ℃, adding the mixture C into an emulsification preparation pot, uniformly stirring at a high speed for 3 minutes, and uniformly stirring;
s6, cooling to 39 ℃, taking materials, detecting, filtering with 500-mesh filter cloth after the materials are qualified, and discharging to obtain the composition.
Example 1
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 2
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 3
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 4
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 5
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
example 6
The embodiment provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 1
The comparative example provides a repairing and whitening composition which comprises the following components in percentage by weight:
comparative example 2
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 3
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
comparative example 4
The comparative example provides a repairing and whitening composition which comprises the following components in percentage by weight:
comparative example 5
The comparative example provides a repairing and whitening composition which comprises the following components in percentage by weight:
comparative example 6
The comparative example provides a repairing and whitening composition, which comprises the following components in percentage by weight:
effect verification 1: security testing
The whitening compositions prepared in all the above examples and comparative examples were subjected to a human safety patch test according to 2015 cosmetic safety techniqueTest of patch on skin of human body in the technical Specification. The method for the skin closed patch test comprises the following steps: selecting 30 persons 18-60 years old, with an area of 50mm or less 2 And a qualified spot test device with a depth of about 1mm, 20mg of the repairing and whitening composition prepared in the above examples and comparative examples was placed in a spot test device chamber, a control hole was blank (no substance was placed), the spot test device with the repairing and whitening composition added was applied to the curved side of the forearm of the subject, and the patch was uniformly applied to the skin by gentle pressure of the palm for 24 hours. The skin reactions were observed according to the standard of table 1 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque tester containing the repairing and whitening composition, respectively, and the observation results were recorded. The patch test results for the repair and whitening composition are shown in table 2.
The experimental results show that the repairing and whitening compositions prepared in all the examples and comparative examples pass the safety test of the human body patch.
TABLE 1 skin closed Patch test skin response grading Standard
TABLE 2 human body safety test results
Sample numbering | 30min | 24h | 48h | Total result |
Example 1 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 2 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 3 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 4 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 5 | 0 | 0 | 0 | No positive reaction for 30 people |
Example 6 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 1 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 2 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 3 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 4 | 0 | 0 | 0 | No positive reaction for 30 people |
Comparative example 5 | 0 | 0 | 0 | No positive reaction for 30 people |
Effect verification 2: determination of melanin
Use ofTesting the melanin content of the skin of the tested area by using MX18 probe for three times, and taking an average value
And (4) judging a result: after the product is used for 0 day, 14 days and 28 days, the MI value of the tested area is obviously reduced compared with that of the blank area, and the tested sample has the whitening effect. As can be seen from table 3, the examples are significantly different from the comparative examples, and under the same conditions, the whitening composition of the present invention can effectively reduce the melanin content of the skin.
TABLE 3
Effect verification 3: skin colour (L and ITA) determination
Skin color (L and ITA) was tested three times using the Skin-Colorimeter CL 400 probe, and averaged.
And (4) judging a result: after 7 days and 14 days of using the product, the L value or the ITA value of the test area is obviously increased compared with that of the blank area, which indicates that the test sample has whitening efficacy. As can be seen from tables 4 and 5, the examples and the comparative examples are significantly different, and under the same conditions, the whitening composition of the present invention can significantly improve the L value and ITA of the skin, and effectively increase the whiteness of the skin.
TABLE 4
TABLE 5
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (6)
1. The repairing and whitening composition is characterized by comprising the following components in percentage by weight:
1 to 2.0 percent of acetyl chitosamine,
glabridin 0.05-1.0 wt%,
0.5 to 2.0 percent of hydrogenated lecithin,
0.3 to 0.5 percent of butyl methoxy dibenzoyl methane,
0.2 to 0.5 percent of tocopherol,
0.01 to 0.03 percent of piperine,
0.1 to 0.2 percent of dipotassium glycyrrhizinate,
0.5 to 3 percent of 4-methoxy potassium salicylate,
0.5 to 3 percent of tranexamic acid,
0.3 to 2 percent of alpha arbutin,
0.5 to 10 percent of nicotinamide,
2 to 10 percent of camellia extract,
0.1 to 2 percent of 3-o-ethyl ascorbic acid,
5 to 10 percent of water,
64-84% of 1, 3-butanediol;
in the composition, the dosage ratio of the glabridin to the tocopherol to the 3-o-ethyl ascorbic acid is (1).
2. A method of preparing the repair and whitening composition of claim 1, comprising the steps of:
s1, adding the butyl methoxy dibenzoyl methane, the tocopherol and the camellia extract into an oil phase preparation pot, heating to 75-85 ℃, and uniformly stirring to obtain a mixture A;
s2, sequentially adding the glabridin, the piperine, the hydrogenated lecithin, the 4-methoxy potassium salicylate and the 1, 3-butanediol into an emulsifying preparation pot, heating to 75-85 ℃, and completely dissolving to obtain a mixture B;
s3, mixing and stirring the water, the acetyl chitosamine, the dipotassium glycyrrhizinate, the tranexamic acid, the alpha arbutin, the nicotinamide and the 3-o-ethyl ascorbic acid uniformly in advance for later use to obtain a mixture C;
s4, adding the mixture A into the mixture B at 75-85 ℃, and uniformly mixing and stirring;
s5, cooling to 45-55 ℃, adding the mixture C into the mixture obtained in the step S4, and uniformly stirring;
s6, cooling to 38-40 ℃, and discharging to obtain the composition.
3. The method for preparing a repairing and whitening composition according to claim 2, characterized in that the step S4 further comprises a step of homogenizing at a high speed for 3-8 minutes before uniformly mixing and stirring.
4. The method for preparing a repairing and whitening composition according to claim 2, characterized in that the step of homogenizing at a high speed for 2-5 minutes is further included before homogenizing in the step S5.
5. The preparation method of the repair and whitening composition of claim 2 or 3, wherein the high speed uniform rate is 2000-4000rpm.
6. The preparation method of the repairing and whitening composition as claimed in claim 2, wherein the step S6 further comprises the steps of taking materials, detecting, filtering with 400-500 mesh filter cloth after passing, and discharging.
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CN104971029A (en) * | 2015-07-31 | 2015-10-14 | 桂林市宏旭生物科技有限公司 | Whitening mask and preparation method thereof |
CN106580792A (en) * | 2016-12-24 | 2017-04-26 | 严志海 | Whitening facial cream and preparation method thereof |
CN109106677B (en) * | 2018-09-30 | 2021-07-23 | 江门职业技术学院 | Composition with whitening function and application thereof |
CN109288715A (en) * | 2018-11-27 | 2019-02-01 | 黄犟兵 | A kind of whitening remediation composition and preparation method thereof |
CN110559243B (en) * | 2019-09-26 | 2022-06-28 | 上海清轩生物科技有限公司 | Repairing and whitening composition containing camellia extract and microcapsule prepared from repairing and whitening composition |
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CN110721104B (en) * | 2019-10-31 | 2020-10-27 | 泉后(广州)生物科技研究院有限公司 | Whitening cream and preparation method thereof |
CN111297745A (en) * | 2019-12-16 | 2020-06-19 | 宁波久瑞生物工程有限公司 | Absorption-promoting whitening composition and production process and application thereof |
CN111450008A (en) * | 2020-04-30 | 2020-07-28 | 广州天玺生物科技有限公司 | Whitening cream and preparation method thereof |
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