CN111956585A - Carnosine freckle removing liquid and preparation method thereof - Google Patents
Carnosine freckle removing liquid and preparation method thereof Download PDFInfo
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Abstract
The invention provides a carnosine freckle-removing liquid and a preparation method thereof, relating to the field of daily chemicals, wherein the freckle-removing liquid comprises the following raw materials: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps extract, angelica sinensis leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avenanthramide, carnosine, propolis extract, aloe vera extract, allantoin, xanthan gum, citrus peel extract, brown algae extract, caprylyl hydroxamic acid, sodium hyaluronate, sodium ascorbate, white willow bark extract, and grapefruit seed extract. The freckle removing liquid prepared by the simple and efficient preparation method through the reasonable proportioning of the components has a good freckle removing effect, and can achieve a good moisturizing effect while removing freckles.
Description
Technical Field
The invention relates to the field of daily chemicals, and particularly relates to a carnosine freckle removing liquid and a preparation method thereof.
Background
The color spot is a common skin disease with brown or melanotic pigmentation and damage on the face due to the increase of skin melanin, is frequently generated on the cheek and forehead, is aggravated after being exposed to the sun, and is frequently seen in women. At present, a plurality of freckle removing modes exist, such as laser freckle removing, regular taking of freckle removing products or use of freckle removing nursing products such as facial masks and freckle removing liquid, and the like, but most of the freckle removing modes have a plurality of problems, such as aggravating deposition of melanin or making skin more fragile and sensitive, further causing the skin to be dry and red blood streak, and the like. Therefore, it is important to find a spot-removing method that can effectively remove spots without damaging the skin.
Chinese patent CN110169936A discloses a multi-vitamin peptide reverse time empty mining repair mask and a preparation method thereof, wherein the mask liquid comprises 67.44-91.84% of water, 2-5% of glycerol, 1-3% of propylene glycol, 0.01-0.4% of sodium hyaluronate, 0.03-0.6% of plant extract, 0.001-0.05% of phloretin, 0.04-1% of triethanolamine, 0.01-0.1% of hydroxyethyl cellulose, 1-5% of carbomer, 0.1-0.2% of transparent xanthan gum, 1-4% of 1, 3-butanediol, 0.5-1% of allantoin, 0.02-0.1% of methyl ester, 1-4% of erythritol, 0.3-0.6% of tranexamic acid, 0.5-2% of viscosity reducer, 0.1-0.6% of defoaming agent, 0.4-4.1% of preservative, 0.15-0.8% of compound biological enzyme, 0. 80.0001-0.001% of acetyl hexapeptide, Carnosine 0.0001-0.001%, essence 0.0003-0.001%, and solubilizer 0.0001-0.001%. The product disclosed by the invention can clean and relieve skin, remove skin free radicals, delay skin aging, resist wrinkles and aging, tighten skin, replenish water and moisturize skin, fade spots and remove freckles, moisten skin, improve skin elasticity, brighten skin color, diminish inflammation and calm skin, and can quickly repair skin problems such as roughness, dullness, sensitive pruritus and the like. Chinese patent CN108938474A discloses a mask containing cordyceps metallothionein and a preparation method thereof, wherein the mask comprises the following components: deionized water, cordyceps extract, carnosine, alpha-arbutin, gentian root extract, sodium hyaluronate, nicotinamide, arginine, allantoin and cosmetic auxiliary materials. The product can repair and resist aging, remove freckles, whiten skin, diminish inflammation, resist allergy, replenish water, moisten skin, regulate skin internally and maintain skin externally, and enables the skin to recover physiological functions and to be healthy and bright. However, the products in the above patents are mainly aimed at repairing, anti-aging and anti-allergy functions, and although effective in removing freckles, the effect is not obvious.
Aiming at the problems of weak freckle removing effect or great skin damage and the like in the prior art, the freckle removing liquid with simple preparation method and excellent freckle removing effect is sought.
Disclosure of Invention
The invention provides a carnosine freckle removing liquid and a preparation method thereof, aiming at the problems in the prior art. The freckle removing liquid is prepared by reasonably proportioning and optimizing raw materials and combining a simple and effective preparation method, and the freckle removing liquid with a strong freckle removing effect and no damage to skin is finally prepared.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a preparation method of a carnosine freckle removing liquid, which comprises the following steps:
(1) uniformly stirring the phase A material, and heating to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat to obtain a mixed material A;
(3) cooling the mixed material A, adding the C-phase material, and stirring to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling and filtering to obtain the material B;
the phase A material comprises: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the phase B material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D-phase material comprises: octanoyl hydroximic acid.
Further, the raw materials of the carnosine freckle removing liquid comprise, by weight: 40-60 parts of water, 2-4 parts of glycerol, 1-2 parts of butanediol, 1-2 parts of betaine, 2-6 parts of carboxymethyl chitosan, 1-7 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1-2 parts of tripeptide-1 copper, 2-4 parts of potato pulp extract, 2-4 parts of cordyceps sinensis extract, 2-4 parts of angelica maritima leaf/stem extract, 3-5 parts of centella asiatica leaf extract, 3-5 parts of magnolia flower extract, 1-4 parts of avenanthramide, 2-5 parts of carnosine, 5-8 parts of propolis extract, 1-3 parts of aloe vera extract, 2-3 parts of allantoin, 1-2 parts of xanthan gum, 1-2 parts of citrus peel extract and 1-2 parts of brown algae extract, 0.5-1.5 parts of caprylyl hydroximic acid, 0.05-0.1 part of sodium hyaluronate, 0.5-1 part of sodium ascorbate, 0.8-1.6 parts of white willow bark extract and 0.8-1.6 parts of shaddock seed extract.
Preferably, the raw materials of the carnosine freckle removing liquid comprise, by weight: 45-55 parts of water, 2-3 parts of glycerol, 1.2-1.8 parts of butanediol, 1-2 parts of betaine, 3-5 parts of carboxymethyl chitosan, 2-6 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1-2 parts of tripeptide-1 copper, 2-3 parts of potato pulp extract, 2-4 parts of cordyceps sinensis extract, 2-4 parts of angelica maritima leaf/stem extract, 4-5 parts of centella asiatica leaf extract, 4-5 parts of magnolia flower extract, 2-3 parts of avenanthramide, 3-5 parts of carnosine, 5-6 parts of propolis extract, 1-2 parts of aloe vera extract, 2-3 parts of allantoin, 1-2 parts of xanthan gum, 1-1.8 parts of citrus peel extract, 1-1.8 parts of brown algae extract, 0.8-1.2 parts of caprylyl hydroximic acid, 0.08-0.1 part of sodium hyaluronate, 0.6-0.8 part of sodium ascorbate, 1-1.5 parts of white willow bark extract and 1-1.5 parts of shaddock seed extract.
Further preferably, the raw materials of the carnosine freckle-removing liquid comprise, by weight: 50 parts of water, 2.5 parts of glycerol, 1.5 parts of butanediol, 1.5 parts of betaine, 4 parts of carboxymethyl chitosan, 5 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1.5 parts of tripeptide-1 copper, 2.5 parts of potato pulp extract, 2.5 parts of cordyceps sinensis extract, 2.5 parts of angelica maritima leaf/stem extract, 4 parts of centella asiatica leaf extract, 4 parts of magnolia flower extract, 2.5 parts of oat alkaloid, 4 parts of carnosine, 5 parts of propolis extract, 1.5 parts of aloe vera extract, 2.5 parts of allantoin, 1.5 parts of xanthan gum, 1.5 parts of citrus peel extract, 1.5 parts of brown algae extract, 1 part of caprylyl hydroximic acid, 0.1 part of sodium hyaluronate, 0.7 part of sodium ascorbate, 1.2 parts of white willow bark extract and 1.2 parts of grapefruit seed extract.
Further, the weight ratio of the carnosine to the cordyceps sinensis extract is 2-5: 2-4. Preferably 8: 5.
Further, the weight ratio of the propolis extract to the avenanthramides is 5-8: 1-4. Preferably 2:1.
Further, the weight ratio of the citrus peel extract, the brown algae extract, the white willow bark extract and the shaddock seed extract is 1-2:1-2:0.8-1.6: 0.8-1.6. Preferably 1.5:1.5:1.2: 1.2.
Further, the heat preservation time in the step (2) is 15-25 min.
Further, the stirring in the step (3) is constant stirring for 15-20min, and the stirring speed is 100-400 rpm.
Further, the temperature of the temperature rise in the step (1) is 70-85 ℃; the temperature for cooling in the step (3) is 40-45 ℃, and the temperature for cooling in the step (4) is below 40 ℃.
The invention also provides the carnosine freckle-removing liquid prepared by the preparation method.
The technical effects obtained by the invention are as follows:
the freckle removing liquid can fully exert the efficacy of carnosine, synergistically dispels the color spots through reasonable composition and proportion of raw materials, does not damage skin, and does not generate anaphylactic reaction. Particularly, the ratio of carnosine to cordyceps sinensis extract, propolis extract to avenanthramide and the like has a remarkable effect on inhibiting tyrosinase, and the ratio relationship of citrus peel extract, white willow bark extract, shaddock seed extract to brown algae extract and the like also has a very critical effect on removing freckles and preserving moisture. The lack of each raw material in the invention is not necessary, and the lack or content change of any ingredient in the raw materials can influence the final properties of the product.
Detailed Description
It is worth to say that the propolis extract, aloe vera extract, centella asiatica leaf extract and white willow bark extract used in the present invention were obtained from sancheng bio-development limited, baoji city; the Cordyceps extract is obtained from Changsha Heihui biotechnology, Inc.; brown algae extract, potato pulp extract, angelica coast leaf/stem extract, magnolia liliiflora extract, citrus peel extract, and grapefruit seed extract were purchased from shanxi new Tian district biotechnology limited; the other raw materials are common commercial products, and thus the sources thereof are not particularly limited.
Example 1
A preparation method of a carnosine freckle removing liquid is characterized by comprising the following steps: the method comprises the following steps:
(1) uniformly stirring the phase A material, and heating to 70 ℃ to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat for 15min to obtain a mixed material A;
(3) cooling the mixed material A to 40 ℃, adding the C-phase material, and stirring for 15min at the stirring speed of 400rpm to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling to below 40 ℃, and filtering to obtain the compound B;
wherein, A phase material includes: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the B phase material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D phase material comprises: octanoyl hydroximic acid.
The carnosine freckle removing liquid comprises the following raw materials in parts by weight: 40 parts of water, 2 parts of glycerol, 1 part of butanediol, 1 part of betaine, 2 parts of carboxymethyl chitosan, 1 part of dipeptide diaminobutyrobenzyl amide diacetate, 1 part of tripeptide-1 copper, 2 parts of potato pulp extract, 2 parts of cordyceps sinensis extract, 2 parts of angelica bihai leaf/stem extract, 3 parts of centella asiatica leaf extract, 3 parts of magnolia flower extract, 1 part of oat alkaloid, 2 parts of carnosine, 5 parts of propolis extract, 1 part of aloe barbadensis extract, 2 parts of allantoin, 1 part of xanthan gum, 1 part of citrus peel extract, 1 part of brown algae extract, 0.5 part of caprylyl hydroximic acid, 0.05 part of sodium hyaluronate, 0.5 part of sodium ascorbate, 0.8 part of white willow bark extract and 0.8 part of shaddock seed extract.
Example 2
A preparation method of a carnosine freckle removing liquid is characterized by comprising the following steps: the method comprises the following steps:
(1) uniformly stirring the phase A material, and heating to 85 ℃ to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat for 25min to obtain a mixed material A;
(3) cooling the mixed material A to 45 ℃, adding the C-phase material, and stirring for 20min at the stirring speed of 100rpm to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling to below 40 ℃, and filtering to obtain the compound B;
wherein, A phase material includes: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the B phase material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D phase material comprises: octanoyl hydroximic acid.
The carnosine freckle removing liquid comprises the following raw materials in parts by weight: 60 parts of water, 4 parts of glycerol, 2 parts of butanediol, 2 parts of betaine, 6 parts of carboxymethyl chitosan, 7 parts of dipeptide diaminobutyrobenzyl amide diacetate, 2 parts of tripeptide-1 copper, 4 parts of potato pulp extract, 4 parts of cordyceps sinensis extract, 4 parts of angelica bihai leaf/stem extract, 5 parts of centella asiatica leaf extract, 5 parts of magnolia flower extract, 4 parts of oat alkaloid, 5 parts of carnosine, 8 parts of propolis extract, 3 parts of aloe barbadensis extract, 3 parts of allantoin, 2 parts of xanthan gum, 2 parts of citrus peel extract, 2 parts of brown algae extract, 1.5 parts of caprylyl hydroximic acid, 0.1 part of sodium hyaluronate, 1 part of sodium ascorbate, 1.6 parts of white willow bark extract and 1.6 parts of shaddock seed extract.
Example 3
A preparation method of a carnosine freckle removing liquid is characterized by comprising the following steps: the method comprises the following steps:
(1) uniformly stirring the phase A material, and heating to 80 ℃ to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat for 20min to obtain a mixed material A;
(3) cooling the mixed material A to 42 ℃, adding the C-phase material, and stirring for 18min at the stirring speed of 200rpm to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling to below 40 ℃, and filtering to obtain the compound B;
wherein, A phase material includes: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the B phase material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D phase material comprises: octanoyl hydroximic acid.
The carnosine freckle removing liquid comprises the following raw materials in parts by weight: 50 parts of water, 2.5 parts of glycerol, 1.5 parts of butanediol, 1.5 parts of betaine, 4 parts of carboxymethyl chitosan, 5 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1.5 parts of tripeptide-1 copper, 2.5 parts of potato pulp extract, 2.5 parts of cordyceps sinensis extract, 2.5 parts of angelica maritima leaf/stem extract, 4 parts of centella asiatica leaf extract, 4 parts of magnolia flower extract, 2.5 parts of oat alkaloid, 4 parts of carnosine, 5 parts of propolis extract, 1.5 parts of aloe vera extract, 2.5 parts of allantoin, 1.5 parts of xanthan gum, 1.5 parts of citrus peel extract, 1.5 parts of brown algae extract, 1 part of caprylyl hydroximic acid, 0.1 part of sodium hyaluronate, 0.7 part of sodium ascorbate, 1.2 parts of white willow bark extract and 1.2 parts of grapefruit seed extract.
Example 4
A preparation method of a carnosine freckle removing liquid is characterized by comprising the following steps: the method comprises the following steps:
(1) uniformly stirring the phase A material, and heating to 70 ℃ to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat for 15min to obtain a mixed material A;
(3) cooling the mixed material A to 40 ℃, adding the C-phase material, and stirring for 15min at the stirring speed of 400rpm to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling to below 40 ℃, and filtering to obtain the compound B;
wherein, A phase material includes: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the B phase material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D phase material comprises: octanoyl hydroximic acid.
The carnosine freckle removing liquid comprises the following raw materials in parts by weight: 45 parts of water, 2 parts of glycerol, 1.2 parts of butanediol, 1 part of betaine, 3 parts of carboxymethyl chitosan, 2 parts of dipeptide diaminobutyrobenzyl amide diacetate, 1 part of tripeptide-1 copper, 2 parts of potato pulp extract, 2 parts of cordyceps sinensis extract, 2 parts of angelica maritima leaf/stem extract, 4 parts of centella asiatica leaf extract, 4 parts of magnolia flower extract, 2 parts of oat alkaloid, 3 parts of carnosine, 5 parts of propolis extract, 1 part of aloe barbadensis extract, 2 parts of allantoin, 1 part of xanthan gum, 1 part of citrus peel extract, 1 part of brown algae extract, 0.8 part of caprylyl hydroximic acid, 0.08 part of sodium hyaluronate, 0.6 part of sodium ascorbate, 1 part of white willow bark extract and 1 part of shaddock seed extract.
Example 5
A preparation method of a carnosine freckle removing liquid is characterized by comprising the following steps: the method comprises the following steps:
(1) uniformly stirring the phase A material, and heating to 85 ℃ to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat for 25min to obtain a mixed material A;
(3) cooling the mixed material A to 45 ℃, adding the C-phase material, and stirring for 20min at the stirring speed of 100rpm to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling to below 40 ℃, and filtering to obtain the compound B;
wherein, A phase material includes: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the B phase material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D phase material comprises: octanoyl hydroximic acid.
The carnosine freckle removing liquid comprises the following raw materials in parts by weight: 55 parts of water, 3 parts of glycerol, 1.8 parts of butanediol, 2 parts of betaine, 5 parts of carboxymethyl chitosan, 6 parts of dipeptide diaminobutyrobenzyl amide diacetate, 2 parts of tripeptide-1 copper, 3 parts of potato pulp extract, 4 parts of cordyceps sinensis extract, 4 parts of angelica maritima leaf/stem extract, 5 parts of centella asiatica leaf extract, 5 parts of magnolia flower extract, 3 parts of oat alkaloid, 5 parts of carnosine, 6 parts of propolis extract, 2 parts of aloe barbadensis extract, 3 parts of allantoin, 2 parts of xanthan gum, 1.8 parts of citrus peel extract, 1.8 parts of brown algae extract, 1.2 parts of caprylyl hydroximic acid, 0.1 part of sodium hyaluronate, 0.8 part of sodium ascorbate, 1.5 parts of white willow bark extract and 1.5 parts of shaddock seed extract.
Comparative example 1
The difference from the embodiment 3 is only that the raw materials of the carnosine freckle-removing liquid comprise the following components in parts by weight: 38 parts of water, 5 parts of glycerol, 0.8 part of butanediol, 2.2 parts of betaine, 1 part of carboxymethyl chitosan, 8 parts of dipeptide diaminobutyrylbenzylamide diacetate, 0.8 part of tripeptide-1 copper, 5 parts of potato pulp extract, 1 part of cordyceps sinensis extract, 5 parts of angelica maritima leaf/stem extract, 2 parts of centella asiatica leaf extract, 6 parts of magnolia flower extract, 0.8 part of oat alkaloid, 6 parts of carnosine, 4 parts of propolis extract, 4 parts of aloe barbadensis extract, 1 part of allantoin, 3 parts of xanthan gum, 0.8 part of citrus peel extract, 2.5 parts of brown algae extract, 0.3 part of octanoyl hydroximic acid, 0.15 part of sodium hyaluronate, 0.3 part of sodium ascorbate, 1.8 parts of white willow bark extract and 0.6 part of grapefruit seed extract.
Comparative example 2
The only difference from example 3 is that the weight ratio of carnosine to Cordyceps sinensis extract was 1:5 (the total weight of both was identical to example 3).
Comparative example 3
The only difference from example 3 is that the weight ratio of propolis extract to avenanthramides is 4:5 (the total weight of both is identical to example 3).
Comparative example 4
The only difference from example 3 is that the weight ratio of citrus peel extract, white willow bark extract, grapefruit seed extract and brown algae extract was 3:0.5:2:0.8 (the total weight of the four was identical to example 3).
Comparative example 5
The only difference from example 3 is that white willow bark extract was not included.
Comparative example 6
The only difference from example 3 is that the brown algae extract was replaced with an equal weight of lavender extract.
In vitro inhibition of tyrosinase
And (3) testing a sample: products prepared in examples 1 to 5 and comparative examples 1 to 6;
the test method comprises the following steps: 1mL of sodium phosphate buffer (1/15mol/L, pH 6.8), 0.5mL of test sample and 1mL of tyrosinase solution (tyrosinase was prepared into a 100U/mL solution using a phosphate buffer solution) were sequentially added to the test tube, water bath was performed at 30 ℃ for 10min, 2.5mL of L-tyrosinase solution (mass fraction 0.05%) as a substrate was added, and then immediately after the time was counted, the absorbance B at 475nm was measured at 20min of the reaction, and the absorbance A was measured in the same manner as in the case where 0.5mL of test sample was not added.
Wherein A is the absorbance of the test sample when the test sample is not added, and B is the absorbance of the test sample.
Three replicates were run for each group and the results are tabulated in table 1.
TABLE 1
| Examples of the invention | Inhibition ratio (%) |
| Example 1 | 97.24 |
| Example 2 | 98.00 |
| Example 3 | 99.67 |
| Example 4 | 98.52 |
| Example 5 | 98.63 |
| Comparative example 1 | 72.35 |
| Comparative example 2 | 85.31 |
| Comparative example 3 | 90.23 |
| Comparative example 4 | 92.20 |
| Comparative example 5 | 93.01 |
| Comparative example 6 | 95.44 |
As can be seen from Table 1, the samples of examples 1-5 of the present invention have good inhibitory effect on tyrosinase, and the inhibitory rate thereof is 97.24-99.67%, wherein the inhibitory rate of the sample of example 3 on tyrosinase is up to 99.67%. The results of the experiments of comparative examples 1 to 6 are all inferior to those of example 3, and it can be seen that the key effects of the composition and the content of the raw materials on the inhibition of tyrosinase by the freckle removing liquid in the invention are that the freckle removing liquid with good inhibition effect on tyrosinase can be obtained only by preparing the freckle removing liquid by adopting the scheme within the protection scope of the invention.
Second, clinical test of speckle removing effect
The test population: 110 volunteers (40 male and 70 female) aged 30-50 were randomly divided into 11 groups of 10 individuals.
A sample to be tested: the products prepared in examples 1 to 5 and comparative examples 1 to 6 (all samples were subjected to sensitization test, and the test results were all safe and harmless).
The test method comprises the following steps: the melanin content, whiteness and moisture content of the face of a tested group before the sample to be tested is smeared are measured, the tested person is smeared with the sample to be tested corresponding to each group after the face is cleaned in the morning and evening respectively, the sample is naturally absorbed when the person is patted and pressed by finger abdomen, any other skin care products related to moisturizing, freckle removing and whitening are not used in the test period, the face change condition of the tested person is detected after the tested person is used for 15 days, and the test result is counted to be shown in a table 2.
TABLE 2
| Examples of the invention | Melanin change ratio (%) | Percent change in whiteness (%) | Moisture content change rate (%) |
| Example 1 | -18.00 | 2.76 | 21.86 |
| Example 2 | -18.53 | 2.82 | 22.06 |
| Example 3 | -19.24 | 3.23 | 23.15 |
| Example 4 | -19.12 | 3.12 | 22.76 |
| Example 5 | -19.09 | 3.01 | 22.25 |
| Comparative example 1 | -10.05 | 1.06 | 12.36 |
| Comparative example 2 | -12.09 | 1.45 | 19.24 |
| Comparative example 3 | -13.37 | 1.53 | 20.53 |
| Comparative example 4 | -14.20 | 1.89 | 15.14 |
| Comparative example 5 | -15.32 | 2.06 | 16.23 |
| Comparative example 6 | -17.06 | 2.43 | 20.26 |
As can be seen from table 2, the anti-freckle liquid containing carnosine according to examples 1 to 5 of the present invention can reduce melanin in the skin and improve the whiteness and moisture content of the face, wherein the anti-freckle liquid according to example 3 is most preferable, and has a melanin reduction rate of 19.24%, a whiteness improvement rate of 3.23%, and a moisture content change rate of 23.15%. The freckle removing liquid in the comparative examples 1 to 6 is relatively inferior to that in the example 3, it is understood that the important significance of the synergistic combination of the components and the content of the raw materials of the freckle removing liquid is that when a part of single or multiple components are replaced, the synergy can generate certain imbalance, and finally the function of the product is weakened.
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A preparation method of a carnosine freckle removing liquid is characterized by comprising the following steps: the method comprises the following steps:
(1) uniformly stirring the phase A material, and heating to completely dissolve the phase A material;
(2) adding the phase B material into the phase A material, stirring and preserving heat to obtain a mixed material A;
(3) cooling the mixed material A, adding the C-phase material, and stirring to obtain a mixed material B;
(4) adding the D-phase material into the mixed material B, stirring, cooling and filtering to obtain the material B;
the phase A material comprises: water, glycerin, butylene glycol, betaine, carboxymethyl chitosan, propolis extract, aloe vera extract, allantoin, xanthan gum, and sodium hyaluronate;
the phase B material comprises: dipeptide diaminobutyrylbenzylamide diacetate, tripeptide-1 copper, potato pulp extract, cordyceps sinensis extract, angelica maritima leaf/stem extract, centella asiatica leaf extract, magnolia lilii flower extract, avena alkaloids, and carnosine;
the C-phase material comprises: citrus peel extract, sodium ascorbate, white willow bark extract, grapefruit seed extract and brown algae extract;
the D-phase material comprises: octanoyl hydroximic acid.
2. The method of claim 1, wherein: the carnosine freckle removing liquid comprises the following raw materials in parts by weight: 40-60 parts of water, 2-4 parts of glycerol, 1-2 parts of butanediol, 1-2 parts of betaine, 2-6 parts of carboxymethyl chitosan, 1-7 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1-2 parts of tripeptide-1 copper, 2-4 parts of potato pulp extract, 2-4 parts of cordyceps sinensis extract, 2-4 parts of angelica maritima leaf/stem extract, 3-5 parts of centella asiatica leaf extract, 3-5 parts of magnolia flower extract, 1-4 parts of avenanthramide, 2-5 parts of carnosine, 5-8 parts of propolis extract, 1-3 parts of aloe vera extract, 2-3 parts of allantoin, 1-2 parts of xanthan gum, 1-2 parts of citrus peel extract and 1-2 parts of brown algae extract, 0.5-1.5 parts of caprylyl hydroximic acid, 0.05-0.1 part of sodium hyaluronate, 0.5-1 part of sodium ascorbate, 0.8-1.6 parts of white willow bark extract and 0.8-1.6 parts of shaddock seed extract.
3. The method of claim 2, wherein: the carnosine freckle removing liquid comprises the following raw materials in parts by weight: 45-55 parts of water, 2-3 parts of glycerol, 1.2-1.8 parts of butanediol, 1-2 parts of betaine, 3-5 parts of carboxymethyl chitosan, 2-6 parts of dipeptide diaminobutyrylbenzylamide diacetate, 1-2 parts of tripeptide-1 copper, 2-3 parts of potato pulp extract, 2-4 parts of cordyceps sinensis extract, 2-4 parts of angelica maritima leaf/stem extract, 4-5 parts of centella asiatica leaf extract, 4-5 parts of magnolia flower extract, 2-3 parts of avenanthramide, 3-5 parts of carnosine, 5-6 parts of propolis extract, 1-2 parts of aloe vera extract, 2-3 parts of allantoin, 1-2 parts of xanthan gum, 1-1.8 parts of citrus peel extract, 1-1.8 parts of brown algae extract, 0.8-1.2 parts of caprylyl hydroximic acid, 0.08-0.1 part of sodium hyaluronate, 0.6-0.8 part of sodium ascorbate, 1-1.5 parts of white willow bark extract and 1-1.5 parts of shaddock seed extract.
4. The method of claim 2, wherein: the weight ratio of the carnosine to the cordyceps sinensis extract is 2-5: 2-4.
5. The method of claim 2, wherein: the weight ratio of the propolis extract to the avenanthramides is 5-8: 1-4.
6. The method of claim 1, wherein: the weight ratio of the citrus peel extract to the brown algae extract to the white willow bark extract to the shaddock seed extract is 1-2:1-2:0.8-1.6: 0.8-1.6.
7. The method of claim 1, wherein: the heat preservation time in the step (2) is 15-25 min.
8. The method of claim 1, wherein: in the step (3), the stirring is performed at a constant speed of 100-400rpm for 15-20 min.
9. The method of claim 1, wherein: the temperature of the temperature rise in the step (1) is 70-85 ℃; the temperature for cooling in the step (3) is 40-45 ℃, and the temperature for cooling in the step (4) is below 40 ℃.
10. A carnosine speckle removing liquid prepared by the preparation method according to any one of claims 1 to 9.
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