CN110339115A - A kind of maintenance Essence and preparation method thereof - Google Patents

A kind of maintenance Essence and preparation method thereof Download PDF

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Publication number
CN110339115A
CN110339115A CN201910751924.8A CN201910751924A CN110339115A CN 110339115 A CN110339115 A CN 110339115A CN 201910751924 A CN201910751924 A CN 201910751924A CN 110339115 A CN110339115 A CN 110339115A
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content
water
phase
butanediol
extract
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CN110339115B (en
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毕凡星
梁开
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Hunan Utopia E-Commerce Co Ltd
Guangdong Bawei Biological Technology Co Ltd
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Hunan Utopia E-Commerce Co Ltd
Guangdong Bawei Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

The invention discloses a kind of maintenance Essences and preparation method thereof, being intended to provide a kind of can effectively improve the penetrating power of skin, balance water storage, promote skin barrier function, it releives anti-inflammatory Essence, technical points include glycerol or the components such as butanediol, erythrite or trehalose, Sodium Hyaluronate, natural plants repair factor, tetrahydro methylpyrimidine carboxylic acid, water // butanediol // amino acid complex, water // Bacillus acidi lactici/fermented soybean product extract // butanediol;Belong to cosmetic technical field.

Description

A kind of maintenance Essence and preparation method thereof
Technical field
The present invention provides a kind of Essence and preparation method thereof;In more detail, it is to be related to a kind of maintenance Essence, belongs to Cosmetic technical field.
Background technique
With people work, the accelerating rhythm of life, various pressure are increasing, along with endure to the fullest extent all day air pollution, The multiple extraneous factors such as screen radiation, ultraviolet light wreck skin, more and more people can be had dry skin, is coarse, obscure, The problems such as microgroove, is perplexed, and as skin protection and the consciousness of repairing is gradually increased in people, for maintenance cosmetics Demand is also constantly expanding.
Currently, maintenance product category in the market is various, skin repair effect is not fully up to expectations, and some there is also Stimulation components, the long-time services such as preservative, fungicide are added in safety issue, such as product can be such that skin gradually appears slightly The reaction such as rough, allergy, destroys human skin barrier instead.Therefore, it is necessary to develop out it is a kind of it is safe, non-stimulated, have no toxic side effect, And the effective cosmetics of maintenance.
Summary of the invention
In view of the above deficiencies, the penetrating power of skin, balance storage can be effectively improved the first purpose of the invention is to provide a kind of Water promotes skin barrier function, releives anti-inflammatory, and safe and non-stimulating reparation Essence.
Second technical solution provided by the invention is the preparation method of above-mentioned maintenance Essence.
For this purpose, first technical solution provided by the present application is such that
A kind of maintenance Essence is made of the raw material components of A phase, B phase, C phase, D phase, E phase, F phase, according to gross mass 100% meter, each phase component mass percentage are as follows:
A phase: water adds to 100%, glycerol or butanediol 1-15%, 1.3- propylene glycol or dipropylene glycol 1-10%, erythrite Or trehalose 1-10%, glycerol // glyceryl acrylate/acrylic copolymer // propylene glycol // water 1-10%, EDETATE SODIUM 0.01-0.2%, Sodium Hyaluronate 0.01-0.2% hydrolyze Sodium Hyaluronate 0.01-0.2%;
B phase: carbomer sodium or polyacrylate cross-linked copolymer -60.01-0.2%, carbomer or acryloyldimethyl ox - 25 Methacrylate Crosspolymer 0.01-0.2% of ichthyodin/docosyl alcohol polyethers;
C phase: 1.3- propylene glycol or dipropylene glycol 1-10%, parahydroxyacet-ophenone 0.1-1%, 1,2- hexylene glycol 0.05- 1%;
D phase: glycerin polyether -26 or methyl gluceth -101-10%, water // ethoxy urea 1-10%, natural plants Repair factor 0.1-5%, tetrahydro methylpyrimidine carboxylic acid 0.5-10%, water // butanediol // amino acid complex 0.5-6%, water // The preceding temple laver amylose 0.01-1% of butanediol // water;
E phase: water // propylene glycol // Codium Tomentosum extract 0.01-1%, water // Bacillus acidi lactici/fermented soybean product extract Object // butanediol 0.001-0.1%, oligofructose // glucose // fructose // sucrose 0.002-0.08%, the filter of rice tunning Liquid 0.002-0.08%, two split yeast tunning lysis object 0.01-0.1%, inulin // water // alpha-glucans oligosaccharides 0.01- 0.1%, carnosine 0.001-0.1%, water 0.001-0.1%;
F phase: Cremophor RH40 0.01-0.5%, essence 0.001-0.1%.
Further, water described in above-mentioned Essence A phase is electroreduction anion water.
Further, natural plants repair factor described in above-mentioned Essence D phase is extracted by butanediol, water, centella Object, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary Leaf extract composition, by its total weight, butanediol content is 50%, water content 38%, and Gotu Kola P.E content is 5%, polygoni cuspidati,radix extractive content is 2%, and scutellariae,radix extractive content is 2%, and tea extract content is 1%, glycyrrhiza glabra Root extract content is 1%, and Flos Chrysanthemi extractive content is 0.5%, and rosemary leaf extract content is 0.5%.
Further, water // butanediol // amino acid complex described in above-mentioned Essence D phase is the mixed of plurality of raw materials Object is closed, by its total weight, water content 67.5-69.1%, butanediol content is 30%, and amino acid complex content is 0.9- 2.5%.
Further, above-mentioned amino acid complex is by lysine, histidine, arginine, aspartic acid, threonine, silk Propylhomoserin, glutamic acid, proline, glycine, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine composition, By its total weight, lysine content 4.2%, histidine content 1.5%, arginine content 3.8%, aspartic acid contains Amount is 8.1%, threonine content 3.1%, serine content 13.9%, content of glutamic acid 12.9%, proline content It is 3.1%, Glycine Levels 25.1%, alanine content 4.5%, valine content 3.1%, isoleucine content is 2.8%, leucine content 7.1%, tyrosine content 3.5%, phenylalanine content 3.3%.
Further, water described in above-mentioned Essence D phase // ethoxy urea be plurality of raw materials mixture, wherein water, The mass ratio of ethoxy urea is 8:9-9:8;The preceding temple laver amylose of water // butanediol // water described in D phase is the mixed of plurality of raw materials Object is closed, by its total weight, water content 69.5%, butanediol content is 30%, and the preceding temple laver amylose content of water is 0.5%.
Further, water // propylene glycol // Codium Tomentosum extract described in above-mentioned Essence E phase is plurality of raw materials Mixture, by its total weight, water content 48-52%, content of propylene glycol 48-52%, Codium Tomentosum extract content is 1-2.5%;Water // Bacillus acidi lactici described in E phase/fermented soybean product extract // butanediol is the mixture of plurality of raw materials, Wherein water, Bacillus acidi lactici/fermented soybean product extract and butanediol mass ratio are 78:10:10.
Further, oligofructose // glucose // fructose // sucrose described in above-mentioned Essence E phase is plurality of raw materials Mixture, by its total weight, oligofructose content is 93%, glucose content 3%, fructose content 2%, cane sugar content It is 2%;Inulin // water // alpha-glucans oligosaccharides described in E phase is the mixture of plurality of raw materials, by its total weight, inulin content For 60-80%, water content 25%, alpha-glucans oligosaccharide content is 1-14%.
Second technical solution provided by the invention is a kind of preparation method of maintenance Essence, mainly includes following steps It is rapid:
1) C phase materials are heated to 70 DEG C, stirring and dissolving is complete, spare;
2) F phase materials stirring at normal temperature is uniform, it is spare;
3) each material of A phase is added in emulsion pot, it is complete is heated to 90 DEG C of stirring and dissolvings;
4) B phase materials are added in step 3) solution after homogeneous 7min is uniformly dispersed, cooling;
5) solution in step 4) is cooled to 45 DEG C, is separately added into each material stirring of C, D, E, F phase pre-processed 15min is uniformly mixed.
The present invention has the advantage that as follows compared with the existing technology:
1, tetrahydro methylpyrimidine carboxylic acid is a kind of potent water-bound forming material in technical solution provided by the invention, can be made Endocellular liberation water-bound increases surrounding water molecules quantity, enhances the interaction between hydrone, and fetter surrounding water Molecule forms complex;Electroreduction anion water, also referred to as small molecule water, its surface tension (25 DEG C of environment lower than water Under, the surface tension 72dyn/cm of water, electroreduction anion water surface tension 56dyn/cm), permeability is more stronger than water, can Achieve the effect that percdation moisturizing, and according to electric double layer principle, electroreduction anion water can by grease (dirt) with Skin surface positively ionized, generates repulsive interaction between grease and skin, so that it is stripped grease (dirt), small molecule Water can also neutralize free radical caused by the factors such as ultraviolet light, aging, tetrahydro methylpyrimidine carboxylic acid and electroreduction anion water Mutual compatibility is wrapped in around cell, enzyme, protein and other organic molecules, is formed to have protection, nourish and stablize hydration and be made Protective shell reaches moisturizing water lock, reduces the effect of water loss, and is avoided that the ambient pressure factor (such as UV radiation, indigo plant Light, dehydration, stimulation etc.) injury to skin, the invasion of combating microorganisms and anaphylactogen, inhibit inflammation stress signal, stablize egg White matter, protected protein matter is from decomposing, thus stabilizing cell membrane, protection cell normal growth metabolism, play it is anti-ageing it is compact, shine The effect of skin gloss, maintenance skin barrier.
2, natural plants repair factor provided by the invention is combined by active components of plants in 7, no cytotoxicity, tool There is the stronger anti-inflammatory effect of releiving, and passes through immunological regulation and releive and reinforce skin barrier;Amino acid complex and skin keratin Layer component is similar, and molecular weight is small can easily penetrate into skin depths, keeps moisture of skin, provides Skin Cell nutrition, make skin Skin fibroblast is proliferated and prevents skin aging;The preceding temple laver amylose of water can form nano-level thin-membrane, protection in skin surface Skin is from environmental stimuli.For a variety of active ingredients in conjunction with tetrahydro methylpyrimidine carboxylic acid, effective component is wrapped in cell peripheral, Keratoderma is penetrated into, moisture can be lockked for skin, prevent dry skin coarse, enabled skin water profit fine and smooth, maintain young healthy State strengthens skin phylactic power defensive power, to protect skin to resist external environmental injury, enhances skin barrier function.
3, containing prebiotics, (inulin, alpha-glucans oligosaccharides, oligofructose, two split yeast fermentation lysis object, rice in the present invention Rice tunning filtrate etc.), probiotics (Bacillus acidi lactici etc.) fermented product, pass through Tiny ecosystem health approach, promote skin surface Growth of probiotics, inhibits harmful bacteria, balance skin microecosystem, while nutrition skin, and the damage of maintenance skin enables skin health It is tough.Cooperate with preceding temple laver amylose of tetrahydro methylpyrimidine carboxylic acid, small molecule water, Codium Tomentosum extract, water etc. a variety of effectively again Ingredient gives the nutriment of skin abundance, continues moisturizing and skin care, is effectively improved dry water deficient skin, reaches deep Spend the effect of moisturizing maintenance skin;The barrier function of skin is safeguarded simultaneously, and anti-inflammatory is antibacterial.
4, maintenance Essence of the invention is without substances such as preservative, animal fat, fluorescer, alcohol, without any stimulation Sense realizes 0 anti-corrosion adding ingredient, while accomplishing without any side effects, and product safety is effective.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below Detailed description.It is worth noting that, unless otherwise indicated, various components used in the present invention are the existing material in this field Material can be bought by commercial channel and obtain or be made by existing method.
Maintenance Essence provided by the invention can be made of embodiment in the following table 1.Wherein, raw material contains in each embodiment Amount is indicated with wt%.
The embodiment of the maintenance Essence provided by the invention of table 1
Repaired in embodiment 1-5 Essence the preparation method is as follows:
1) C phase materials are heated to 70 DEG C, stirring and dissolving is complete, spare;
2) F phase materials stirring at normal temperature is uniform, it is spare;
3) each material of A phase is added in emulsion pot, it is complete is heated to 90 DEG C of stirring and dissolvings;
4) B phase materials are added in step 3) solution after homogeneous 7min is uniformly dispersed, cooling;
5) solution in step 4) is cooled to 45 DEG C, is separately added into each material stirring of C, D, E, F phase pre-processed 15min is uniformly mixed.
In addition, being directed to present invention point, the present invention is also provided with the comparative example 1-5 in table 2, maintenance essence in comparative example The specific ingredient and content of magnificent liquid are as shown in table 2 below.
The comparative example provided by the invention of table 2
Wherein, comparative example 1 compared with Example 3, in D phase the natural plants maintenance of tetrahydro methylpyrimidine carboxylic acid equivalent because Filial generation is replaced, i.e., natural plants repair factor content is 4.5%;Comparative example 2 compared with Example 3, in D phase natural plants maintenance because Water // butanediol // amino acid complex of sub- equivalent replaces, i.e., water // butanediol // amino acid complex content is 2.5%; Comparative example 3 compared with Example 3, E Xiang Zhongshui // Bacillus acidi lactici/fermented soybean product extract // butanediol equivalent water // The preceding temple laver amylose of butanediol // water replaces, i.e., the preceding temple laver amylose content of water // butanediol // water is 0.61%;Comparative example 4 with Embodiment 3 is compared, and tetrahydro methylpyrimidine carboxylic acid and rice tunning filtrate in E phase and oligofructose // glucose in D phase // The deionized water of the equivalent of fructose // sucrose replaces;Comparative example 5 and embodiment 3 compare, A phase small molecular water deionization Water replaces.
Natural plants repair factor is by butanediol, water, Gotu Kola P.E, tiger described in above-described embodiment and comparative example Cane root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leave are extracted Object composition, by its total weight, butanediol content is 50%, water content 38%, and Gotu Kola P.E content is 5%, polygonum cuspidate Root extract content is 2%, and scutellariae,radix extractive content is 2%, and tea extract content is 1%, glycyrrhiza glabra root extract Content is 1%, and Flos Chrysanthemi extractive content is 0.5%, and rosemary leaf extract content is 0.5%.
Further, water // butanediol // amino acid complex described in above-mentioned Essence D phase is the mixed of plurality of raw materials Object is closed, by its total weight, water content 67.5-69.1%, butanediol content is 30%, and amino acid complex content is 0.9- 2.5%.
The amino acid complex is by lysine, histidine, arginine, aspartic acid, threonine, serine, paddy ammonia Acid, proline, glycine, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine composition, by its total weight Meter, lysine content 4.2%, histidine content 1.5%, arginine content 3.8%, aspartate content 8.1%, Threonine content is 3.1%, serine content 13.9%, content of glutamic acid 12.9%, and proline content 3.1% is sweet Histidine content is 25.1%, alanine content 4.5%, valine content 3.1%, isoleucine content 2.8%, bright ammonia Acid content is 7.1%, tyrosine content 3.5%, phenylalanine content 3.3%.
The water // ethoxy urea be plurality of raw materials mixture, wherein water, ethoxy urea mass ratio be 8:9-9: 8;The preceding temple laver amylose of water // butanediol // water is the mixture of plurality of raw materials, and by its total weight, water content is 69.5%, butanediol content is 30%, and the preceding temple laver amylose content of water is 0.5%.
Water // propylene glycol // the Codium Tomentosum extract is the mixture of plurality of raw materials, and by its total weight, water contains Amount is 48-52%, and content of propylene glycol 48-52%, Codium Tomentosum extract content is 1-2.5%;Water // cream described in E phase Acidfast bacilli/fermented soybean product extract // butanediol is the mixture of plurality of raw materials, wherein water, Bacillus acidi lactici/fermented soybean Product extract and butanediol mass ratio are 78:10:10.
The preparation method of maintenance Essence the preparation method is the same as that of Example 1 in -5 maintenance Essence in comparative example 1-5.
In order to preferably prove technical solution provided by the present application, the application is given below, the detection examination of technical solution is provided It tests:
1. skin irritation is tested
1) test sample: maintenance Essence made from 1-5 of the embodiment of the present invention.
2) test method: choose 25 female volunteers, be randomly divided into 5 groups (every group 5), subject should meet volunteer into Select standard, no allergic dermatitis history, and the previous moon that excitant product is also not used.
Maintenance Essence about 0.020~0.025mL of Example 1-5 preparation is applied to spot tester (Beijing science popularization instrument plant) In cell, external application special adhesive tape is pasted on subject back, removes spot tester after 24 hours, if any the wet paper of surplus products Towel is gently wiped, respectively at 0.5 hour, 24 hours, 48 hours, by dermoreaction in " cosmetics safety technical specification " (2015) Grade scale records its result.Standard of perfection is shown in Table 3.
3 standard of perfection of table
By enclosed type patch test result it is found that 25 subjects were at 0.5 hour, 24 hours, 48 hours to embodiment 1-5 Maintenance Essence obtained does not show any adverse reaction, the symptoms such as erythema, burn feeling, itch does not occur.Illustrate this hair Bright maintenance Essence safety, it is non-stimulated to skin.
2. moisture content of skin is tested
Test method: volunteer 50 for choosing 20~45 years old are used as object on probation, and 50 volunteers are randomly divided into 10 Group (every group 5), subjects skin's health, meets inclusion criteria.Each subject in the morning uniformly smear facial later by face cleaning The maintenance Essence of embodiment 1-5, comparative example 1-5 are tested respectively using moisture content of skin tester Corneometer CM825 Before cosmetics, and using the water content of skin after 1 hour and 8 hours, select subject's forehead position as tested area Domain is repeated 5 times respectively, obtains average value, calculates the growth rate of skin moisture content.During experiment, subject is in experiment portion Position cannot smear any other cosmetics.
Skin moisture content Growth Rate Calculation formula is as follows:
Skin moisture content growth rate %=(MMVt-MMV0)/MMV0× 100%;
MMV0: use preceding moisture content of skin;
MMVt: use moisture content of skin after t hours.
Skin moisture content growth rate measurement result is shown in Table 4.
4 moisture content of skin test result of table
From the experimental result of table 4 it is found that after using maintenance Essence 1h prepared by the present invention, skin moisture content growth rate Skin moisture content growth rate can also maintain 39% or more after can reach 46% or more, 8h, illustrate the maintenance Essence pair Skin has preferable moisturizing moisten effect, and can reach the effect of long-acting water lock moisturizing, and skin moisture content increases in comparative example Long rate is smaller, and moistening effect is poor, illustrates that each component is synergistic in maintenance Essence of the present invention, and there is good moisturizing to make With the effect of moistening skin smooth, reach lasting moisturizing.
3, skin barrier function is tested
Skin water loss amount TEWL is the important parameter for assessing moisture of skin protection layer function, can be used to evaluate skin screen Hinder the power of function.Protective layer of skin is better, and moisture content is higher, and the numerical value of skin water loss TEWL is lower, TEWL Unit are as follows: g/hm2
Test method: volunteer 50 for choosing 20~45 years old are used as object on probation, and 50 volunteers are randomly divided into 10 Group (every group 5), subjects skin's health, meets inclusion criteria.Each subject in the morning uniformly smear facial later by face cleaning The maintenance Essence of embodiment 1-5, comparative example 1-5 are tested using Tewameter TM300 respectively before using cosmetics, and Using the TEWL value of skin behind 1 hour and 8 hours, select subject's forehead position as tested region, and calculate TEWL value Change rate.Change rate (%)=(using rear water loss amount-starting moisture number of dropouts)/starting moisture number of dropouts, it is average to become The sum of rate (%)=every group of TEWL value change rate/this group of number, this value is smaller, illustrates that water loss is smaller, test specimen skin Skin barrier function is stronger.During experiment, subject cannot smear any other cosmetics in Test sites.Skin TEWL measurement knot Fruit is shown in Table 5.
5 skin barrier function test result of table
The maintenance Essence that can be seen that embodiment from the experimental result in table 5 is preferable to skin barrier function, skin after 1h The skin TEWL value average rate of change reaches 25% or more after reaching 30% or more, 8h, and uses comparative example maintenance Essence, skin TEWL value change rate is smaller, illustrates that maintenance Essence prepared by the present invention can reinforce the barrier function of skin, resists external environment Infringement to skin.
4, antiallergy efficacy test
Test philosophy: when allergy originally subintrusion body, body generates antibody IgE, when anaphylactogen invades body again, It is combined with the IgE antibody on sensitized cell surface, FceRI crosslinking occurs, to start activation signals, priming signal conduction makes A variety of enzyme activations including hyaluronidase intracellular, this process are referred to as allergic reaction.Therefore, it can use hyaluronic acid enzyme activity Property inhibiting rate come judge antiallergic activity, the hyaluronidase activity inhibiting rate the high, reflects that the antiallergic effect of the ingredient is stronger, instead It is then weaker.
Test method: 0.1mL 0.25mmo1/LCaC1 is added in test tube2Solution and 0.5mL hyaluronic acid enzyme solution (500U/ml), 37 DEG C of heat insulating culture 20min are separately added into 0.5mL embodiment 1,3,5, the maintenance Essence of comparative example 1,3,5, 37 DEG C of heat insulating culture 20min;0.5mL Sodium Hyaluronate liquid, 37 DEG C of heat preservation 30min are added;Then room temperature stands 5min, is added 0.4mo1/LNaOH solution 0.1mL and second phthalein acetone soln 0.5mL, ice bath 5min at once after heating reaction 15min in boiling water bath; It adds 1.0mL Ehrlich's reagent and is diluted with 3.0mL dehydrated alcohol, developed the color after placing 20min, with light splitting light Degree meter measures its absorbance value at 530nm, substitutes into following formula and calculates inhibiting rate.Measurement result is shown in Table 6.
Hyaluronic acid enzyme inhibition rate (%)=[(A-B)-(C-D)]/(A-B) × 100%
In formula:
A-contrast solution absorbance value (replaces sample solution with acetic acid buffer solution)
B-placebo solution absorbance value (replaces sample solution and enzyme solution with acetic acid buffer solution)
C-test sample solution absorbance value
D-sample blank solution absorbance value (replacing enzyme solution with acetic acid buffer solution)
Evaluation criterion: for the ease of evaluating sample antiallergic activity, referring to international standard, antiallergic effect is divided into 4 grades below: inhibiting rate >=70% is strong anti-allergic effects;Inhibiting rate >=50% is medium anti-allergic effects;30%≤inhibiting rate < 50% is weak anti-allergic effects;Inhibiting rate < 30% is no anti-allergic effects.
6 antiallergic efficacy test result of table
Sample Embodiment 1 Embodiment 3 Embodiment 5 Comparative example 1 Comparative example 3 Comparative example 5
Inhibiting rate (%) 72.30% 75.48% 80.12% 47.81% 43.57% 58.66%
Can be seen that embodiment maintenance Essence from the experimental result of table 6 can significantly inhibit hyaluronidase activity, inhibit Rate is all larger than 70%, shows there is strong anti-allergic effects, and comparative example shows weak anti-allergic effects, illustrates maintenance essence of the present invention Liquid has effects that releive, antiallergy.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention, It should be equivalent substitute mode, be included within the scope of the present invention.

Claims (9)

1. a kind of maintenance Essence, which is characterized in that it is made of the raw material components of A phase, B phase, C phase, D phase, E phase, F phase, according to Gross mass 100% is counted, and each phase component mass percentage is as follows:
A phase: water adds to 100%, glycerol or butanediol 1-15%, 1.3- propylene glycol or dipropylene glycol 1-10%, erythrite or sea Algae sugar 1-10%, glycerol // glyceryl acrylate/acrylic copolymer // propylene glycol // water 1-10%, EDETATE SODIUM 0.01- 0.2%, Sodium Hyaluronate 0.01-0.2% hydrolyze Sodium Hyaluronate 0.01-0.2%;
B phase: carbomer sodium or polyacrylate cross-linked copolymer -60.01-0.2%, carbomer or acryloyldimethyl taurine - 25 Methacrylate Crosspolymer 0.01-0.2% of ammonium/docosyl alcohol polyethers;
C phase: 1.3- propylene glycol or dipropylene glycol 1-10%, parahydroxyacet-ophenone 0.1-1%, 1,2- hexylene glycol 0.05-1%;
D phase: glycerin polyether -26 or methyl gluceth -101-10%, water // ethoxy urea 1-10%, natural plants maintenance Factor 0.1-5%, tetrahydro methylpyrimidine carboxylic acid 0.5-10%, water // butanediol // amino acid complex 0.5-6%, water // fourth two The preceding temple laver amylose 0.01-1% of alcohol // water;
E phase: water // propylene glycol // Codium Tomentosum extract 0.01-1%, water // Bacillus acidi lactici/fermented soybean product extract // Butanediol 0.001-0.1%, oligofructose // glucose // fructose // sucrose 0.002-0.08%, rice tunning filtrate 0.002-0.08%, two split yeast tunning lysis object 0.01-0.1%, inulin // water // alpha-glucans oligosaccharides 0.01- 0.1%, carnosine 0.001-0.1%, water 0.001-0.1%;
F phase: Cremophor RH40 0.01-0.5%, essence 0.001-0.1%.
2. maintenance Essence according to claim 1, which is characterized in that water described in A phase be electroreduction bear from Sub- water.
3. maintenance Essence according to claim 1, which is characterized in that natural plants repair factor described in D phase by Butanediol, water, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, German chamomile flower extract, rosemary leaf extract composition, based on natural plants repair factor total weight 100%, butanediol content is 50%, water content 38%, Gotu Kola P.E content is 5%, and polygoni cuspidati,radix extractive content is 2%, and radix scutellariae root extract contains Amount is 2%, and tea extract content is 1%, and glycyrrhiza glabra root extract content is 1%, and Flos Chrysanthemi extractive content is 0.5%, rosemary leaf extract content is 0.5%.
4. maintenance Essence according to claim 1, which is characterized in that water // butanediol // amino acid described in D phase Compound is the mixture of plurality of raw materials, and by its total weight, water content 67.5-69.1%, butanediol content is 30%, ammonia Base acid complex content is 0.9-2.5%.
5. maintenance Essence according to claim 4, which is characterized in that the amino acid complex is by lysine, group ammonia Acid, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, isoleucine, Leucine, tyrosine, phenylalanine composition, by amino acid complex total weight, lysine content 4.2%, histidine contains Amount is 1.5%, arginine content 3.8%, aspartate content 8.1%, threonine content 3.1%, serine content It is 13.9%, content of glutamic acid 12.9%, proline content 3.1%, Glycine Levels 25.1%, alanine content is 4.5%, valine content 3.1%, isoleucine content 2.8%, leucine content 7.1%, tyrosine content is 3.5%, phenylalanine content 3.3%.
6. maintenance Essence according to claim 1, which is characterized in that water described in D phase // ethoxy urea is more The mixture of kind of raw material, wherein water, ethoxy urea mass ratio be 8:9-9:8;Water // butanediol // Shui Qiansi described in D phase Laver amylose is the mixture of plurality of raw materials, and by its total weight, water content 69.5%, butanediol content is 30%, before water Temple laver amylose content is 0.5%.
7. maintenance Essence according to claim 1, which is characterized in that water // propylene glycol described in E phase // fur pine Algae extract is the mixture of plurality of raw materials, by its total weight, water content 48-52%, content of propylene glycol 48-52%, Codium Tomentosum extract content is 1-2.5%;Water // Bacillus acidi lactici described in E phase/fermented soybean product extract // fourth two Alcohol is the mixture of plurality of raw materials, and wherein water, Bacillus acidi lactici/fermented soybean product extract and butanediol mass ratio are 78:10: 10。
8. maintenance Essence according to claim 1, which is characterized in that oligofructose // glucose // fruit described in E phase Sugar // sucrose is the mixture of plurality of raw materials, and by its total weight, oligofructose content is 93%, glucose content 3%, fruit Sugared content is 2%, cane sugar content 2%;Inulin // water // alpha-glucans oligosaccharides described in E phase is the mixture of plurality of raw materials, By its total weight, inulin content 60-80%, water content 25%, alpha-glucans oligosaccharide content is 1-14%.
9. the preparation method of maintenance Essence described in claim 1, which is characterized in that mainly include the following steps:
1) C phase materials are heated to 70 DEG C, stirring and dissolving is complete, spare;
2) F phase materials stirring at normal temperature is uniform, it is spare;
3) each material of A phase is added in emulsion pot, it is complete is heated to 90 DEG C of stirring and dissolvings;
4) B phase materials are added in step 3) solution after homogeneous 7min is uniformly dispersed, cooling;
5) solution in step 4) is cooled to 45 DEG C, is separately added into each material stirring 15min of C, D, E, F phase pre-processed, mixed It closes uniform.
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CN110755351A (en) * 2019-11-29 2020-02-07 广州英桐生物科技有限公司 Whitening, moisturizing and repairing composition and application thereof
CN111297745A (en) * 2019-12-16 2020-06-19 宁波久瑞生物工程有限公司 Absorption-promoting whitening composition and production process and application thereof
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