CN114224818A - Anti-allergy composition and preparation method and application thereof - Google Patents
Anti-allergy composition and preparation method and application thereof Download PDFInfo
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- CN114224818A CN114224818A CN202111546428.2A CN202111546428A CN114224818A CN 114224818 A CN114224818 A CN 114224818A CN 202111546428 A CN202111546428 A CN 202111546428A CN 114224818 A CN114224818 A CN 114224818A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention discloses an anti-allergy composition and a preparation method and application thereof, and relates to the technical field of cosmetics. The invention provides an anti-allergy composition, which comprises the following components: extract of leaf, root and stem of Piper methysticum (Pipermethysticum), lactobacillus/soybean milk fermentation product filtrate, biogel-2, biogel-4, and ecological nutrient solution; the ecological nutrient solution comprises inulin and alpha-glucan oligosaccharide. According to the anti-allergy composition provided by the invention, all components are synergistic, so that the generation of a sensitive phenomenon of skin after being stimulated by the outside can be prevented or reduced; and the first aid of the sensitive skin (has the functions of instant analgesia, allergy relieving and anti-inflammation, can reduce the skin allergy rate, relieve the allergy phenomenon and improve the self-resistance of the skin aiming at the fragile and sensitive skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-allergy composition and a preparation method and application thereof.
Background
With the change of the external environment and the daily life habits of people, the life pressure is increased, the resistance of the people to the external environment begins to decline, and the frequency of the sensitive problems of the skin with different sexes or different age stages is continuously increased. Uncontrollable factors such as ultraviolet rays, climate and the like can cause skin sensitivity. Meanwhile, with the improvement of living standard and the acceleration of living rhythm, more and more consumers pay more attention to products with high efficacy and quick effect, and the micro-shaping of medical science and beauty also becomes a heat bar. Frequent use of highly effective and quick-acting cosmetics by consumers, even blind selection or use of poor quality products and inappropriate medical and aesthetic means, causes more and more external invasion of the skin, the skin barrier function becomes more and more fragile, many adult consumers and even teenagers suffer from sensitive skin, and the decline of the skin defense causes a list of skin problems such as stinging, itching, dry skin and the like.
There are many factors that induce skin sensitivity, including endogenous factors and exogenous factors. Endogenous factors such as lifestyle habits or body's autoimmune problems can cause skin sensitivity. Exogenous factors such as excessive cleansing, use of high efficacy cosmetics or inferior cosmetics, cosmetic film materials or environmental factors, etc. The consumer does not clearly judge the sensitivity of the consumer to the skin of the consumer, and common anti-skin-sensitivity products in the market are mainly used as entry points in the aspects of anti-inflammation moisturizing, skin micro-ecological balance or barrier repair, and generally the products have good relieving and regulating effects on some aspects of skin sensitivity, so that people with sensitive skin are difficult to regulate and improve the sensitive skin state by using one product, the skin sensitivity cannot be immediately and effectively relieved, and the selection of the products by the consumer is also greatly limited, for example, the use selection of some effective products with adaptive reaction in the use process can be greatly influenced, such as whitening, freckle removing and sunscreen products.
Disclosure of Invention
Based on the situation, the invention aims to overcome the defects of the prior art and provide the skin care product which can prevent the generation of normal skin sensitivity; emergency treatment, allergy relief and repair of sensitive skin; an anti-allergy composition capable of improving the skin resistance, and a preparation method and application thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: an anti-allergy composition comprising the following components: extract of leaf, root and stem of Piper METHYSTICUM (Piper METHYSTICUM), lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4, and ecological nutrient solution; the ecological nutrient solution comprises inulin and alpha-glucan oligosaccharide.
The inventor relieves the skin sensitivity from multiple chemical, biological, physical and other layers and reduces the skin sensitivity. The kava (Piper METHYSTICUM) leaf/root/stem extract, the lactobacillus/soybean milk fermentation product filtrate, the biological carbohydrate gum-2, the biological carbohydrate gum-4 and the ecological nutrient solution are mutually cooperated, so that the generation of a normal skin sensitivity phenomenon can be better prevented; performing first aid, allergy relief and repair on sensitive skin; and can better improve the resistance of the skin.
The extract of the leaves, roots and stems of the kava (Piper METHYSTICUM) has the functions of instant sedation and anti-inflammation. Kavalactones are the major group of functional molecules containing kavain, dihydrokavain, methoxykavain and desmethoxykavain. Blocking neuronal transmission of information by kavain occupying GABA-a receptors and inhibiting PGE2 reduces the sensation of pain primarily on nerve endings and creates comfort by stimulating GABA receptors.
The lactobacillus/soybean milk fermentation product filtrate is a probiotic metabolite, and achieves the effects of stabilizing a skin immune barrier and a vitamin barrier and repairing a physical barrier by maintaining the diversity of skin microbial flora, inhibiting IgE immunoglobulin, inhibiting the generation of an inflammation stress medium PGE2 prostaglandin and regulating the skin acid mask environment, reducing the skin allergy rate and recombining the skin.
The biological carbohydrate gum-2 acts on a keratinocyte receptor, and achieves the effects of inhibiting inflammation and relieving by inhibiting interleukin-1 alpha synthesis, neutrophil adhesion, the activity of PLA2, the synthesis of PGE2 and promoting the release of beta-endorphin pleasure factors.
The biological carbohydrate gum-4 is deacetylated polysaccharide, can form a transparent and easily-removed non-closed matrix film on skin, can resist the permeation and damage of pollutants, protects the skin from oxidation reaction caused by external pollution and inflammation caused by induced free radicals, protects the vitality of cells and organisms, and enhances the natural defense mechanism of the skin.
The ecological nutrient solution is obtained by extracting chicory roots and then carrying out enzyme catalysis, and contains natural polysaccharide components of alpha-glucan oligosaccharide and inulin. The alpha-glucan oligosaccharide and inulin have the functions of prebiotics, can inhibit the growth of harmful bacteria, promote the growth of beneficial bacteria, regulate the balance of skin microbial flora and improve skin immunity.
Preferably, the anti-allergy composition comprises the following components in parts by weight: 0.001-0.02 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.01-0.5 part of lactobacillus/soybean milk fermentation product filtrate, 0.15 part of biological sugar gum-20.002, 0.1 part of biological sugar gum-40.002 and 0.5-5 parts of ecological nutrient solution. The applicant of the invention researches and discovers through a large number of creative tests that the components of the anti-allergy composition can better exert the synergistic effect of the components within the selection range of the weight parts.
Preferably, the anti-allergy composition comprises the following components in parts by weight: 0.003-0.015 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.03-0.3 part of lactobacillus/soybean milk fermentation product filtrate, 20.01-0.1 part of biological sugar gum, 40.006-0.05 part of biological sugar gum and 1-3 parts of ecological nutrient solution. The applicant of the invention finds that the components of the anti-allergy composition have better synergistic effect within the selection range of the weight parts through a large amount of creative tests.
Preferably, the anti-allergy composition comprises the following components in parts by weight: 0.01 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.2 part of lactobacillus/soybean milk fermentation product filtrate, 20.05 parts of biological sugar gum, 40.025 parts of biological sugar gum and 2 parts of ecological nutrient solution. The applicant of the invention researches and discovers through a large number of creative tests that the components of the anti-allergy composition have the best effect within the selection range of the specific weight parts.
In addition, the invention provides the application of the anti-allergy composition in cosmetics. The cosmetic is at least one of essence, cream, water and lotion.
Further, the invention provides essence which comprises the following components in parts by weight: 0.001-0.02 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.01-0.5 part of lactobacillus/soybean milk fermentation product filtrate, 0.83-0.15 part of biological carbohydrate gum, 0.5-5 parts of biological carbohydrate gum-40.002-0.1 part of ecological nutrient solution, 0.1-1 part of thickening agent, 2-6 parts of humectant and 1 part of preservative.
Preferably, the thickening agent is hydrolyzed sclerotium rolfsii gum; the humectant is 1, 3-butanediol, and the preservative is a compound of p-hydroxyacetophenone and 1, 2-hexanediol.
The invention also provides a preparation method of the essence, which comprises the following steps:
(1) adding the thickening agent into water, and stirring until the thickening agent is completely swelled;
(2) mixing the preservative and the humectant, heating to 55-65 ℃, stirring until the preservative and the humectant are completely dissolved, adding the mixture into the step (1), and uniformly stirring;
(3) adding extract of leaf, root and stem of Piper METHYSTICUM (Piper METHYSTICUM), lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4, and ecological nutrient solution, stirring, and filtering with filter screen to obtain the essence;
further, the invention provides a face cream which comprises the following components in parts by weight: 0.001-0.02 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.01-0.5 part of lactobacillus/soybean milk fermentation product filtrate, 0. 20.002-0.15 part of biological sugar gum, 40.002-0.1 part of biological sugar gum, 0.5-5 parts of ecological nutrient solution, 0.1-1 part of thickening agent, 3-8 parts of humectant, 1 part of preservative, 2-6 parts of emulsifier and 10-20 parts of grease.
Preferably, the thickener is an ammonium acryloyldimethyltaurate/VP copolymer; the humectant is a compound of 1, 3-butanediol and glyceryl polyether-26; the grease is a compound of squalane, common coltsfoot seed oil, polydimethylsiloxane, caprylic/capric triglyceride, morroni, safflower oil/palm oil aminopropanediol esters; the emulsifier is a Xianting liquid crystal moisturizing emulsifier; the Xianting liquid crystal moisturizing emulsifier is a compound of 4 components, namely a compound of cetearyl glucoside, sorbitan stearate, glyceryl stearate and cetearyl alcohol.
The invention also provides a preparation method of the face cream, which comprises the following steps:
(1) mixing an emulsifier and grease, heating to 75-85 ℃, and stirring until the emulsifier and the grease are completely dissolved to obtain an oil phase;
(2) mixing a thickening agent and a humectant, stirring and dispersing, adding into water, heating to 80-85 ℃, and stirring until complete swelling to obtain a water phase;
(3) adding the oil phase prepared in the step (1) into the water phase prepared in the step (2), dispersing and homogenizing for 3-5 minutes, stirring and cooling to 40-50 ℃ to obtain a mixed solution;
(4) and (3) sequentially adding the extract of the leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM), the filtrate of the lactobacillus/soybean milk fermentation product, the biological carbohydrate gum-2, the biological carbohydrate gum-4, the ecological nutrient solution and the preservative into the mixed solution prepared in the step (3), and uniformly stirring to obtain the face cream.
Compared with the prior art, the invention has the beneficial effects that: (1) the invention provides an anti-allergy composition containing an extract of leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM), a lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4 and an ecological nutrient solution, wherein the components are mutually synergistic, so that the generation of a normal skin sensitivity phenomenon can be better prevented; performing first aid, allergy relief and repair on sensitive skin; and can better improve the resistance of the skin. (2) The compound synergy of the composition aims at solving the problem of skin sensitivity caused by various factors, and aims at immediately and effectively calming and relieving skin sensitivity caused by different causes of endogenous and exogenous factors and then resisting inflammation for different causes of inflammation, so that the skin sensitivity state is further improved by synergy of protection and repair. Thus, the compositions of the present invention provide an all-round solution to the problem of treating sensitive skin. (3) The composition can be conveniently added into common products of cosmetics or different product formulations in the aspect of product application technology, and has wide application range due to wide pH tolerance range and high ion compatibility of the product.
Drawings
FIG. 1 is an image of an Antera 3D photographic face of the cream provided in example 7;
FIG. 2 is an image of an Antera 3D photograph of a face of a commercially available anti-allergy repair product.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to the accompanying drawings and specific embodiments. In the examples, the experimental methods used were all conventional methods unless otherwise specified, and the materials, reagents and the like used were commercially available without otherwise specified.
Examples 1 to 8 and comparative examples 1 to 5
The invention sets the following embodiments 1-8, the selection of the components and the parts by weight of the specific embodiments 1-8 are shown in table 1, the specific components and the parts by weight of the essence in the embodiments 1-6 are shown, and the total parts by weight is 100; examples 7-8 are shown for specific components and parts by weight of the cream, the total parts by weight being 100 parts;
the preparation method of the essence of embodiment 1 of the invention comprises the following steps:
(1) adding the thickening agent into water, and stirring until the thickening agent is completely swelled;
(2) mixing the preservative and the humectant, heating to 55-65 ℃, stirring until the preservative and the humectant are completely dissolved, adding the mixture into the step (1), and uniformly stirring;
(3) adding extract of leaf, root and stem of Piper METHYSTICUM (Piper METHYSTICUM), lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4, and ecological nutrient solution, stirring, and filtering with filter screen to obtain the essence;
the preparation methods of embodiments 2 to 6 are completely the same as those of embodiment 1, and are not repeated herein.
The preparation method of the cream of the embodiment 7 of the invention comprises the following steps:
(1) mixing an emulsifier and grease, heating to 75-85 ℃, and stirring until the emulsifier and the grease are completely dissolved to obtain an oil phase;
(2) mixing a thickening agent and a humectant, stirring and dispersing, adding into water, heating to 80-85 ℃, and stirring until complete swelling to obtain a water phase;
(3) adding the oil phase prepared in the step (1) into the water phase prepared in the step (2), dispersing and homogenizing for 3-5 minutes, stirring and cooling to 40-50 ℃ to obtain a mixed solution;
(4) and (3) sequentially adding the extract of the leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM), the filtrate of the lactobacillus/soybean milk fermentation product, the biological carbohydrate gum-2, the biological carbohydrate gum-4, the ecological nutrient solution and the preservative into the mixed solution prepared in the step (3), and uniformly stirring to obtain the face cream.
The preparation methods of embodiment 8 and embodiment 7 are completely the same, and are not repeated herein.
TABLE 1 examples 1-8 component and part by weight selection
Meanwhile, the invention is provided with comparative examples 1 to 5, and the specific arrangement of the comparative examples is shown in the following table 2:
TABLE 2 comparative examples 1-5 component and part by weight selection
Comparative example 1 is a single comparison with example 3, and does not contain the extract of the leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM), and the rest components, parts by weight and preparation method are completely the same;
comparative example 2 is compared with example 3 singly, and does not contain lactobacillus/soybean milk fermentation product filtrate, and the rest components, parts by weight and preparation method are completely the same;
comparative example 3 is compared with example 3 singly, and does not contain lactobacillus/soybean milk fermentation product filtrate and bioglycan-2, and the rest components, parts by weight and preparation method are completely the same;
comparative example 4 is a single comparison with example 3, the weight parts of the extract of the leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM) are not within the range provided by the invention, and the rest components, weight parts and preparation method are completely the same;
the total weight parts of the anti-allergy composition of comparative example 5 are completely the same as example 3, but the components of the lactobacillus/soybean milk fermentation product filtrate, the bioglycan-2 and the ecological nutrient solution are not selected in the protection scope of the invention, and the rest components, the weight parts and the preparation method are completely the same;
in order to further verify the efficacy and the optimal proportion of the composition in the technical scheme of the invention, the following efficacy evaluation experiments are made:
experiment-lactic acid tingling test (LAST)
Stimulus: 10% lactic acid aqueous solution
Test article: experimental examples 1 to 8, comparative examples 1 to 5
The test personnel: 65 persons, 5 persons were a test group;
the evaluation method comprises the following steps: 4-division method data judgment standard: grading into 4 grades, wherein 0 is asymptomatic, 1 is slight stimulation, 2 is moderate stimulation, and 3 is severe stimulation;
the test conditions are as follows: the tested person is positive in lactic acid stimulation test. The evaluation method comprises the following steps: after cleansing, 50 μ L of 10% lactic acid aqueous solution was applied to one side of nasolabial sulcus, subjective symptoms of the subject were asked at 0, 2.5, 5, and 8min after application, and self-assessment scoring was performed by 4-point method (0 was no stinging sensation, 1 was mild stinging, 2 was moderate stinging, and 3 was severe stinging), and it was positive for lactic acid stimulation if the sum of the two test scores was not less than 3.
The test method comprises the following steps: at room temperature, 50 μ L of aqueous lactic acid solution with a content of 10% was applied to the nasolabial fold and any one of the cheeks, and then 50mg of the test substance was applied uniformly, and the subjective symptoms of the subjects were asked at 0 minute, 5 minutes, and 15 minutes, respectively, and scored by 4 points (0 point was no stinging sensation, 1 point was mild stinging, 2 point was moderate stinging, and 3 point was severe stinging).
And (3) testing results: the pain feeling self-evaluation is carried out for the tested subjects at 0min, 5min and 15min after the use, and the average value of the test results is taken for analyzing the improvement rate.
TABLE 3
As can be seen from the tests of examples 1-8 and comparative examples 1-5, the compositions of this patent have a better sting relief effect in the range of uses protected, but the effect is clearly reduced when the amount is reduced or one of the ingredients is removed; when the dosage is increased beyond the patent protection range, the effect cannot be obviously enhanced, and even the effect is weakened due to the influence of the raw materials.
Experiment two: TEWL transepidermal water loss
Testing an instrument: vapometer percutaneous water loss measuring instrument, manufacturer: delfin
The test substance: examples 1 to 8, comparative examples 1 to 5
The test personnel: 52, 4 persons/group
The test conditions are as follows: 1) the subjects belong to sensitive muscles or are in a sensitive period due to the influence of external factors recently; 2) testing a subject with facial skin TEWL value greater than 25 by a percutaneous water loss measuring instrument; 3) the same subject performs the test for the same tester, and the person responsible for the test is skilled in the operation of the detection instrument; 4) the testee cleans the face according to the standard requirement before testing, sits still for 20 minutes in a testing environment meeting the conditions and cannot drink water and beverages; 5) and (3) test environment: the temperature is 21 +/-1 ℃, and the relative humidity is 50 +/-5%;
the test method comprises the following steps: the testees are respectively smeared with the test object and common moisturizing water self-made by a laboratory after cleaning the face in the morning and evening, and the test is carried out by an instrument for 0 day, 14 days and 28 days, wherein the test result is the average value of all the testees;
and (3) test results: as shown in table 4:
TABLE 4
From the comparison of the tests of examples 1-8 and comparative examples 1-5, the compositions of examples 3, 6, 7, 8 work best, and examples 2, 4, secondly, examples 1, 5 work relatively weakly; the efficacy test effect of the examples 7 and 8 is weaker than that of the examples 3 and 6, so that the formula containing the grease has an auxiliary synergistic effect on barrier repair of the sensitive and dry muscles.
From the test of the comparative example, it can be seen that the effect is significantly reduced when one of the components of the composition is removed; the efficacy of the ingredients of the composition is not significantly enhanced when the ingredients are outside the scope of the claims. It can be seen that the composition ingredients in the scope of use as claimed in this patent have a significant synergistic effect in improving the percutaneous water loss of sensitive muscles, and therefore are effective in repairing the skin barrier function of sensitive muscles.
Experimental three Antera 3D face photograph imaging and analysis
The tested person: 10 persons, 5 persons/group
The tested test piece: the test person is evaluated by a dermatologist as moderately and severely damaged skin accompanied by symptoms of reddening and dryness and itching of the skin
The test substance: the resulting cream prepared in example 7; commercially available anti-allergy repair products;
the test method comprises the following steps: the subjects were applied with the test substance after cleaning their faces in the morning and evening, and the values of hemoglobin (ultra-high concentration) and affected area were monitored by the instrument at 0 day, 7 days, 14 days, and 28 days, and the test results were the average value of each group of subjects.
Testing an instrument: miravex ANTERA 3D skin image analyzer;
and (3) testing results: as shown in table 5;
TABLE 5
As shown by the comparison of the example 7 and the improvement test of the commercial products on the sensitive skin heme, the composition has good anti-allergic effect on the damaged and allergic skin, not only takes effect quickly, but also has better final effect than the comparative commercial anti-allergic repair products.
Experiment four-seal patch test
The test substance: test 1 was the cream of example 8; the test substance 2 is a facial cream prepared by adding no extract of leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM) of the anti-allergy composition, lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4 and ecological nutrient solution in example 8;
subject: 30 people, 17 women and 3 men, the average age is 29 plus or minus 1 year, and the health condition of the subjects is good.
The test method comprises the following steps: selecting qualified spot test equipment, respectively placing about 0.02-0.025g of test substance in a spot test device, externally applying hypoallergenic adhesive tape to the arm of a subject, removing the test substance after 24 hours, respectively observing skin reactions 0.5, 24 and 48 hours after removal, and recording the results according to the skin reaction grading standard in the current effective technical specification.
Test standards: as shown in table 6:
TABLE 6
And (3) test results: as shown in table 7;
TABLE 7
Compared with the patch test results of the test object 1 and the test object 2, the test object 1 added with the composition has obvious effect of relieving the product containing the irritant.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. An anti-allergy composition, comprising the following components: extract of leaf, root and stem of Piper METHYSTICUM (Piper METHYSTICUM), lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4, and ecological nutrient solution; the ecological nutrient solution comprises inulin and alpha-glucan oligosaccharide.
2. The anti-sensitivity composition according to claim 1, comprising the following components in parts by weight: 0.001-0.02 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.01-0.5 part of lactobacillus/soybean milk fermentation product filtrate, 0.15 part of biological sugar gum-20.002, 0.1 part of biological sugar gum-40.002 and 0.5-5 parts of ecological nutrient solution.
3. The anti-sensitivity composition according to claim 2, comprising the following components in parts by weight: 0.003-0.015 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.03-0.3 part of lactobacillus/soybean milk fermentation product filtrate, 20.01-0.1 part of biological sugar gum, 40.006-0.05 part of biological sugar gum and 1-3 parts of ecological nutrient solution.
4. The anti-sensitivity composition according to claim 3, comprising the following components in parts by weight: 0.01 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.2 part of lactobacillus/soybean milk fermentation product filtrate, 20.05 parts of biological sugar gum, 40.025 parts of biological sugar gum and 2 parts of ecological nutrient solution.
5. Use of an anti-allergy composition according to any of claims 1 to 4 in cosmetics.
6. The essence is characterized by comprising the following components in parts by weight: 0.001-0.02 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.01-0.5 part of lactobacillus/soybean milk fermentation product filtrate, 0.83-0.15 part of biological carbohydrate gum, 0.5-5 parts of biological carbohydrate gum-40.002-0.1 part of ecological nutrient solution, 0.1-1 part of thickening agent, 2-6 parts of humectant and 1 part of preservative.
7. The essence of claim 6, wherein the preparation method of the essence comprises the following steps:
(1) adding the thickening agent into water, and stirring until the thickening agent is completely swelled;
(2) mixing the preservative and the humectant, heating to 55-65 ℃, stirring until the preservative and the humectant are completely dissolved, adding the mixture into the step (1), and uniformly stirring;
(3) adding extract of leaf, root and stem of Piper METHYSTICUM (Piper METHYSTICUM), lactobacillus/soybean milk fermentation product filtrate, biological carbohydrate gum-2, biological carbohydrate gum-4, and ecological nutrient solution, stirring, and filtering with filter screen to obtain the essence.
8. The face cream is characterized by comprising the following components in parts by weight: 0.001-0.02 part of Piper METHYSTICUM (Piper METHYSTICUM) leaf/root/stem extract, 0.01-0.5 part of lactobacillus/soybean milk fermentation product filtrate, 0. 20.002-0.15 part of biological sugar gum, 40.002-0.1 part of biological sugar gum, 0.5-5 parts of ecological nutrient solution, 0.1-1 part of thickening agent, 3-8 parts of humectant, 1 part of preservative, 2-6 parts of emulsifier and 10-20 parts of grease.
9. The cream of claim 8, wherein the cream is prepared by a method comprising the steps of:
(1) mixing an emulsifier and grease, heating to 75-85 ℃, and stirring until the emulsifier and the grease are completely dissolved to obtain an oil phase;
(2) mixing a thickening agent and a humectant, stirring and dispersing, adding into water, heating to 80-85 ℃, and stirring until complete swelling to obtain a water phase;
(3) adding the oil phase prepared in the step (1) into the water phase prepared in the step (2), dispersing and homogenizing for 3-5 minutes, stirring and cooling to 40-50 ℃ to obtain a mixed solution;
(4) and (3) sequentially adding the extract of the leaves, roots and stems of Piper METHYSTICUM (Piper METHYSTICUM), the filtrate of the lactobacillus/soybean milk fermentation product, the biological carbohydrate gum-2, the biological carbohydrate gum-4, the ecological nutrient solution and the preservative into the mixed solution prepared in the step (3), and uniformly stirring to obtain the face cream.
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CN116350566A (en) * | 2023-02-17 | 2023-06-30 | 广州市妆泽生物科技有限公司 | Preparation method of skin nourishing and allergy relieving combined by multiple plant extracts |
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