CN113925796B - Application of plant component with resisting type relieving effect - Google Patents
Application of plant component with resisting type relieving effect Download PDFInfo
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- CN113925796B CN113925796B CN202111098763.0A CN202111098763A CN113925796B CN 113925796 B CN113925796 B CN 113925796B CN 202111098763 A CN202111098763 A CN 202111098763A CN 113925796 B CN113925796 B CN 113925796B
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- China
- Prior art keywords
- lactic acid
- skin
- composition
- tara gum
- stinging
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- 230000000694 effects Effects 0.000 title abstract description 13
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 192
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 96
- 239000004310 lactic acid Substances 0.000 claims abstract description 96
- 239000002537 cosmetic Substances 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims description 40
- 239000000213 tara gum Substances 0.000 claims description 27
- 235000010491 tara gum Nutrition 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 25
- 230000007794 irritation Effects 0.000 claims description 11
- 230000000979 retarding effect Effects 0.000 claims description 6
- 230000001815 facial effect Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 241001424341 Tara spinosa Species 0.000 abstract description 25
- 239000000126 substance Substances 0.000 abstract description 9
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 57
- 208000002193 Pain Diseases 0.000 description 36
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 18
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 18
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- 238000002474 experimental method Methods 0.000 description 4
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- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
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- 230000000087 stabilizing effect Effects 0.000 description 2
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- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
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- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
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- 235000017399 Caesalpinia tinctoria Nutrition 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 235000017848 Rubus fruticosus Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
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- 206010040830 Skin discomfort Diseases 0.000 description 1
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- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000388430 Tara Species 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
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- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
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- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
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- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940083608 sodium hydroxide Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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- 239000002699 waste material Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
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- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an application of a plant component with a resisting type relieving effect, namely an application of Caesalpinia spinosa L in preparing skin care products and/or cosmetics, wherein the care products or cosmetics contain lactic acid or substances containing the lactic acid.
Description
Technical Field
The invention relates to the field of daily chemical industry, in particular to application of Caesalpinia spinosa L.
Background
Sensitive muscles are a common skin problem, accounting for about 36% of women in our country. Pain and itching are the types of discomfort that frequently occur to sensitive skin, and are caused by non-irritating ingredients. The formation of sensitive muscles is mainly due to barrier defects, nerve fiber overreactions and inflammation in the skin. Lactic acid stinging is a common method for identifying sensitive muscle groups. Typically, 5% or 10% aqueous lactic acid is applied to the nasal wing sites and the severity of discomfort at the test site is scored by the subject, who then calculates the LAST value to distinguish whether the subject is sensitive. The LAST score of lactic acid stinging was also confirmed in the literature by Ding et al to be significantly positively correlated with the discomfort symptoms of stinging and itching of the skin of the Chinese sensitive muscle group. In the cosmetic field, some components have the effect of relieving irritation. For example, mehdi Sakka et al, applied a 10% lactic acid solution to the nasal wings and applied biosugar after the subject felt the stimulusCan remarkably relieve skin irritation. Even so, discomfort caused by lactic acid has developed and subsequent relief makes it difficult to alter the unpleasant experience of the product during use. Lactic acid (one of fruit acids) has a comprehensive and excellent skin care effect and is often used in skin care products.
Therefore, there is an urgent need in the art to find a component that can resist the discomfort of skin caused by lactic acid, so as to better exert the beneficial effects of lactic acid in promoting the exfoliation of old and waste keratinocytes on skin, improving skin color and tendering skin.
Disclosure of Invention
The present invention aims to provide a method for reducing the feeling of irritation (e.g., stinging, etc.) felt by the skin when lactic acid is used.
In a first aspect of the invention there is provided the use of Caesalpinia spinosa in the preparation of a skin care and/or cosmetic product, the care or cosmetic product comprising lactic acid or a substance comprising lactic acid.
In another embodiment, the care or cosmetic product comprises from 0.01 to 2.0wt% of Caesalpinia spinosa gum, based on the total weight of the care or cosmetic product.
In another embodiment, the skin is facial skin.
In a second aspect of the invention, there is provided a method of retarding and/or alleviating the irritation of lactic acid to skin, the method comprising the steps of: the lactic acid or the lactic acid-containing substance is used together with the Caesalpinia spinosa L.or a composition comprising lactic acid or the lactic acid-containing substance and Caesalpinia spinosa L.is used.
In another embodiment, the use comprises applying to the skin.
In another embodiment, the Caesalpinia spinosa is present in an amount of 0.01 to 2.0wt% based on the total weight of the composition.
In another embodiment, the composition is a skin care and/or cosmetic.
In another embodiment, the skin is facial skin.
In a third aspect of the invention, there is provided the use of tara gum for retarding and/or reducing the irritation of lactic acid to the skin.
In a fourth aspect of the invention, there is provided the use of Caesalpinia spinosa in the preparation of a composition for retarding and/or reducing the irritation of lactic acid to the skin.
In a fifth aspect of the present invention, there is provided a method of using Caesalpinia spinosa, the method comprising applying to the skin a composition comprising lactic acid or a substance comprising lactic acid and Caesalpinia spinosa.
In another embodiment, the Caesalpinia spinosa is present in an amount of 0.01 to 2.0wt% based on the total weight of the composition.
The present invention provides a composition which can resist the discomfort caused by lactic acid to the skin, thereby improving the skin tone and caring the skin.
Drawings
Fig. 1 shows the time for the first stinging of volunteers caused by the 10% lactic acid and 10% lactic acid+0.5% tara gum mix in the experimental example.
Figure 2 shows the stinging scores of volunteer experiences at different times for the 10% lactic acid and 10% lactic acid +0.5% tara gum mix in the experimental example.
Fig. 3 shows the number of human volunteers receiving stimulation with 10% lactic acid and 10% lactic acid+0.5% tara gum mix, respectively, in the experimental example.
Fig. 4 shows the time for the first stinging of volunteers caused by the 10% lactic acid and 10% lactic acid+2% trehalose mixture in the experimental example.
Figure 5 shows the stinging scores of volunteers at different times for the 10% lactic acid and 10% lactic acid+2% trehalose blends of the experimental examples.
Fig. 6 shows the number of human volunteers receiving stimulation with 10% lactic acid and 10% lactic acid+2% trehalose mixture, respectively, in the experimental example.
Detailed Description
The inventor has conducted extensive and intensive studies to find that the use of Caesalpinia spinosa gum together with lactic acid can delay the time of stinging felt by human skin and reduce the perceived extent of stinging, thereby enabling a person to be more tolerant to stimulation caused by lactic acid. On this basis, the present invention has been completed.
As used herein, "L-lactic acid" and "lactic acid" are used interchangeably and refer to small molecule alpha-hydroxy acids of the left-handed structure of formula i:
as used herein, "lactic acid-containing substance" refers to a plant extract or microorganism having lactic acid contained therein, which may be, but is not limited to, sambucus nigra, blackberry, sunflower, bilberry, etc.; the microorganism may be, but is not limited to, lactobacillus, microbial fermentation products, such as sugarcane fermentation products, and the like.
As used herein, "tara gum" refers to a glycan consisting of galactomannans having the structure shown in formula ii:
n is at least 10.
As used herein, "trehalose" is a non-reducing disaccharide consisting of two glucose molecules. The structure is alpha-D-glucopyranosyl-alpha-D-glucopyranoside, and the structure is shown in the following formula III:
trehalose has the effect of stabilizing cell membranes, and has been shown to have the effects of moisturizing, soothing, stabilizing proteins, reducing skin cell damage, and the like in the skin and health fields.
As used in the present invention, "skin" refers to the tissue of the body surface, which is outside the muscle, and is in direct contact with the external environment, and has the functions of protecting, excreting, regulating body temperature, feeling external stimulus, etc.
As used herein, "care" refers to the treatment of human skin for non-therapeutic purposes, including but not limited to, cleansing, moisturizing, oil control, sun protection, anti-acne, anti-aging, pore size reduction, and the like, including, but not limited to, applying a product having at least one of these effects to the outside of the skin.
As used herein, "make-up" refers to rendering, drawing, finishing on the surface of human skin for non-therapeutic purposes, enhancing stereoscopic impression, adjusting shape and color, masking imperfections, and appearing look-up, thereby beautifying visual perception, including but not limited to, for human faces.
As used herein, "delay the stimulation of skin by lactic acid" refers to delaying the time that skin feels stinging caused by lactic acid (e.g., without limitation, 5% or 10% aqueous lactic acid), for at least 3-5% of the time.
As used herein, "reducing the irritation of lactic acid to the skin" refers to a reduction in the degree of stinging caused by the perception of lactic acid by the skin (e.g., without limitation, 5% or 10% aqueous lactic acid), if the stinging score in the lactic acid stinging human body experimental method described in the general consensus of the chinese sensitive skin diagnosis specialist is reduced by at least 15%, such as, without limitation, 16-30%, 20-25%, etc.; and also reduces the peak tingling sensation caused by lactic acid (e.g., without limitation, 5% or 10% aqueous lactic acid).
As used herein, "combatting" refers to delaying and/or lessening the stimulation of the skin by lactic acid, i.e., being able to delay the time that stimulation occurs for the first time and reduce the sensation of stimulation when used with lactic acid.
As used herein, the term "soothing" refers to reducing skin discomfort and improving skin's tolerance to external stimuli. The effect preferably means a reduction in the feeling of redness, stinging, itching, etc. of the skin or in the inflammatory response.
"composition" refers to a substance that, when applied to a subject (generally referred to as a human), is capable of inducing a desired efficacy on or in the skin.
As used herein, the term "cosmetically acceptable carrier" refers to a carrier that makes the cosmetic or personal care product applicable, including various excipients and diluents, which are not per se essential active ingredients, and which are not overly toxic after application. Suitable vectors are well known to those of ordinary skill in the art. A sufficient discussion of cosmetically acceptable excipients can be found in cosmetic hygiene specifications 2015. Such carriers in the compositions may include humectants, emulsifiers, thickeners, chelating agents, emollients, and the like. For example, but not limited to, water, 1, 2-hexanediol, p-hydroxyacetophenone, butanediol, panthenol, dipotassium glycyrrhizinate, arginine, glycerol, betaine, sodium hyaluronate, propylene glycol, sodium hydroxide, glycerol stearate/PEG-100 stearate, glycerol stearate, ethylhexyl glycerol, xanthan gum, hydroxyethyl cellulose, xanthone, carbomer, disodium EDTA, isohexadecane, isooctyl palmitate, cetostearyl alcohol, polydimethylsiloxane, citric acid or salts thereof, behenyl alcohol, behenyl polyether, cetyl polyether, pentaerythritol tetra (ethyl hexanoate), squalane, cetyl ethyl hexanoate, isooctyl palmitate, phenoxyethanol, and the like.
The term "administering" as used herein refers to directly applying the composition, such that a comparable amount of the composition is formed on the skin of the individual to which it is applied.
The term "individual" or "personal" is used herein to refer to a person who may receive the compositions and/or methods for use on the skin.
As used herein, "room temperature" means 15-45℃and preferably 20-35 ℃.
The invention provides a composition, which contains lactic acid and Caesalpinia spinosa, and can be solid or liquid; in one embodiment of the invention, the liquid is an aqueous solution.
In one embodiment of the present invention, the Caesalpinia spinosa is contained therein in an amount of 0.01 to 2.0wt%, such as, but not limited to, 0.05 to 1.5wt%, 0.1 to 0.8wt%, 0.07 to 1.7wt%, etc., based on the total weight of the composition.
The compositions provided herein are generally obtained by mixing lactic acid and tara gum.
Further, the compositions provided herein may be mixed with a cosmetically acceptable carrier to provide a variety of cosmetic or care products that may be applied to human skin, including, but not limited to, barrier creams, sun creams, face creams, eye creams, lotions, essences, lotions, gels, lipsticks, concealers, creams, and the like.
The cosmetic or care product provided by the invention contains the dosage range meeting the national industry standard, such as, but not limited to, 0.3-3.0wt% of lactic acid, 0.7-1.3wt%, 0.8-2.5wt% and the like.
The cosmetic or care product provided by the invention contains 0.01-2.0wt% of Caesalpinia spinosa, such as but not limited to 0.05-1.7wt%, 0.14-1.4wt% and the like.
The present invention provides for the use of tara gum, including its use for non-therapeutic purposes to delay and/or reduce the irritation of lactic acid to the skin, including, but not limited to, causing stinging, itching, etc.
The invention provides a use method of Caesalpinia spinosa champ gum, which comprises the following steps: the Caesalpinia spinosa Thunb gel is applied to skin.
In one embodiment of the present invention, the lactic acid and the tara gum are applied to the skin at the same time, for example, the composition containing the lactic acid and the tara gum provided by the present invention is applied to the skin; or the cosmetic or care product provided by the invention is smeared on the skin.
In a preferred form of the invention, the Caesalpinia spinosa is applied to the skin of the face.
The application method of the Caesalpinia spinosa L provided by the invention is for non-therapeutic purpose, and is for enabling people to feel comfortable and pleasant when caring for and/or making up skin.
The present invention provides a method for retarding and/or reducing the irritation of lactic acid to skin, comprising applying the composition comprising lactic acid and tara provided by the present invention as described above to skin; or applying the cosmetic or care product provided by the invention described above to the skin. Preferably applied to facial skin.
The method for delaying and/or relieving the stimulation of the lactic acid to the skin is a non-therapeutic purpose, and is a method for making people feel comfortable and pleasant when skin care and/or make-up is performed.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. However, any numerical value inherently contains certain standard deviations found in their respective testing measurements. As used herein, "about" generally means that the actual value is within plus or minus 10%, 5%, 1% or 0.5% of a particular value or range. Alternatively, the term "about" means that the actual value falls within an acceptable standard error of the average value, as determined by one of ordinary skill in the art. Except in the experimental examples, or where otherwise explicitly indicated, all ranges, amounts, values, and percentages used herein (e.g., to describe amounts of materials, lengths of time, temperatures, operating conditions, ratios of amounts, and the like) are to be understood to be modified by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the present specification and attached claims are approximations that may vary depending upon the desired properties. At least these numerical parameters should be construed as the number of significant digits and by applying ordinary rounding techniques.
Unless defined otherwise herein, the meanings of scientific and technical terms used herein are the same as commonly understood and used by one of ordinary skill in the art. Furthermore, as used in this specification, the singular noun encompasses the plural version of the noun without conflict with the context; plural nouns as used also encompasses singular versions of the noun.
So that those skilled in the art can appreciate the features and effects of the present invention, a general description and definition of the terms and expressions set forth in the specification and claims follows. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and in the event of a conflict, the present specification shall control.
The theory or mechanism described and disclosed herein, whether right or wrong, is not meant to limit the scope of the invention in any way, i.e., the present disclosure may be practiced without limitation to any particular theory or mechanism.
In this document, all features, such as values, amounts, and concentrations, are for brevity and convenience only, as defined in the numerical or percent range. Accordingly, the description of a numerical range or percentage range should be considered to cover and specifically disclose all possible sub-ranges and individual values (including integers and fractions) within the range.
The above-mentioned features of the invention, or of the embodiments, may be combined in any desired manner. All of the features disclosed in this specification may be used in combination with any combination of features, provided that the combination of features is not inconsistent and all such combinations are contemplated as falling within the scope of the present specification. The various features disclosed in the specification may be replaced by alternative features serving the same, equivalent or similar purpose. Thus, unless expressly stated otherwise, the disclosed features are merely general examples of equivalent or similar features.
The invention has the main advantages that: the composition and the method provided by the invention can effectively improve the tolerance of skin to lactic acid stimulation, so that even people with sensitive muscles can obtain the beneficial effect of lactic acid with the dosage meeting the national industry standard when using cosmetics and/or nursing products.
The invention will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. The experimental procedures, which do not address the specific conditions in the examples below, are generally carried out under conventional conditions or under conditions recommended by the manufacturer. All percentages, ratios, proportions, or parts are by weight unless otherwise indicated. The units in weight volume percent are well known to those skilled in the art and refer, for example, to the weight of solute in 100 milliliters of solution. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the methods of the present invention. The preferred methods and materials described herein are presented for illustrative purposes only.
All percentages in the examples are wt%
Lactic acid used in the examples below was purchased from purac ltd (thailand), tara gum from Seppic (france) and trehalose from hayashibiara (japan).
Experimental filter paper was purchased from beijing baiyi da technology development limited.
Test examples
Materials:
10% aqueous lactic acid solution
Test sample: 0.5% Caesalpinia spinosa aqueous solution and 2% trehalose aqueous solution
Screening of muscle groups of I-sensitive humans (2.5 min+5 min) (min is the meaning of minutes)
Lactic acid sensitive volunteers were screened by the lactic acid stinging human body experimental method described in the "Chinese sensitive skin diagnosis expert consensus": the test method was that filter paper sheets having a diameter of about 8mm were placed on both sides of the nasolabial folds at room temperature, and 10% aqueous lactic acid solution or distilled water was added dropwise (control group). The subjects were asked to feel at 30s, 2.5min, 5min, 8min, respectively, and were scored for tingling, with scores of 0,1,2, 3.
| Score value | Feel of sensation |
| 0 | No feeling at all |
| 1 | A slight feel, which is felt but not the most clear |
| 2 | Medium sensation, clear sensation, but also can be tolerated |
| 3 | Severe feeling and intolerance |
According to the consensus of Chinese sensitive skin diagnosis and treatment specialists, sensitive skin is screened by using a lactic acid stinging method, and the main index is the sum of skin stinging scores of 2.5min and 5 min. When the score of the time node is more than or equal to 3, the subject can be judged to be sensitive skin.
II subject: 20 subjects who were positive for lactic acid stinging (i.e., people who were "sensitive skin" as a result of the above test)
Test sample: the 10% lactic acid aqueous solution is applied to one side of the nasal wing of the subject at random, and the mixed solution of lactic acid with the concentration of 10% and the test sample is arranged on the other side of the nasal wing of the subject
And (3) judging: randomly and separately smearing the lactic acid solution or the lactic acid plus test sample solution on the left face nasal wing or the right face nasal wing of the subject, wherein the subject does not know the information and only scores the stinging feeling of the left half face and the right half face according to the requirement
Recording the content:
A. time to first discomfort
B. The stinging is scored at 30s, 2.5min, 5min and 8min, the score is 0-10 score, the score of 0 represents no discomfort, the score of 10 represents intolerance of stinging, and the larger the number is, the stronger the discomfort is
C. Comparison of the intensity of the stimulus on both sides at each time point
D. Volunteers review and compare the overall discomfort of the left and right half faces
III analysis of results
See fig. 1,2,3, 4, 5, and 6, respectively.
According to the first stinging time of fig. 1, the average time of 10% of lactic acid sites of all volunteers was 96.77 seconds, and the average time after adding tara gum was delayed to 104.05 seconds, indicating that tara gum delayed the occurrence of lactic acid stimulation.
According to fig. 2: the front 30s of stinging scores, the single 10% of lactic acid stinging scores are 14 points, and the stinging scores of the added Caesalpinia spinosa are 10 points, so that 29% of stinging scores are reduced, which means that the skin stinging response caused by lactic acid is immediately relieved by the Caesalpinia spinosa. The stabbing pain scores at the 3 time points of 2.5min, 5min and 8min, the lactic acid scores of 10% alone are 56, 93 and 109, and the Caesalpinia spinosa is 41, 76 and 84. The tingling sensation is reduced by 27%,18% and 23% respectively, so that the tingling and tara gum can be obtained, and the uncomfortable sensation in the whole time period is relieved.
According to fig. 3, by asking the subjects, looking back at the overall discomfort during the test, 82% of the volunteers considered 10% lactic acid more stinging, and only 18% of the people considered adding tara gum more stinging, indicating that tara gum alleviates the discomfort for the vast majority of sensitive muscle groups.
According to fig. 4, the time to first stinging was 71.05 seconds on average for 10% of all volunteers and 65.45 seconds after the addition of trehalose, indicating that trehalose failed to delay the onset of lactic acid stimulation.
According to the scores of the first 30s stings in FIG. 5, 10% of lactic acid stings alone had a score of 11 and the added trehalose stings had a score of 16, indicating that trehalose did not immediately reduce the effect of lactic acid stings. The stabbing pain scores at 3 time points of 2.5min, 5min and 8min, the lactic acid scores of 10% alone are 70, 88 and 96, and the trehalose is added to the mixture for 60, 82 and 95. It can be derived that trehalose lacks the effect of alleviating the discomfort of multiple time periods in a more important time period.
Figure 6 shows that 55% of volunteers consider the addition of trehalose to be more stink and only 45% of people consider 10% of lactic acid to be more stink by asking the subjects for overall discomfort during the retrospective test, indicating that trehalose cannot alleviate the stink sensation caused by lactic acid.
Caesalpinia spinosa L.and trehalose are also sugar substances, and the Caesalpinia spinosa L.has the effect of delaying lactic acid stinging, while the trehalose does not.
Note that: the experiment used high concentrations of lactic acid to stimulate the skin, and the amount of lactic acid added to the cosmetic was less than this concentration. The maximum addition amount of lactic acid (alpha-hydroxy acid and salts and esters) is 6% according to 2015 'cosmetic safety technical Specification'. The inventors therefore believe that the use of tara gum better delays and reduces the irritation, discomfort and peaks of lactic acid in cosmetics.
Use example 1
Use of example 2
Use of example 3
The foregoing description is only illustrative of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, which is defined broadly in the appended claims, and any person skilled in the art to which the invention pertains will readily appreciate that many modifications, including those that fall within the metes and bounds of the claims, or equivalence of such metes and bounds thereof.
Claims (12)
1. Use of tara gum in the preparation of a composition for retarding and/or reducing the irritation of lactic acid to skin; the composition is a care product or a cosmetic containing high-concentration lactic acid;
in said application, wherein the amount of tara gum is from 0.05 to 2.0wt% based on the total weight of the composition;
in the application, the amount of the high concentration lactic acid is selected from the group consisting of: 10wt% or 5wt%.
2. The use according to claim 1, wherein the skin is facial skin.
3. The use according to claim 1, wherein the amount of tara gum is 0.05-1.5wt%, based on the total weight of the composition.
4. The use according to claim 1, wherein the amount of tara gum is 0.07-1.7wt%, based on the total weight of the composition.
5. The use according to claim 4, wherein the amount of tara gum is 0.1-1wt%, based on the total weight of the composition.
6. The use according to claim 5, wherein the amount of tara gum is 0.1 to 0.8wt%, based on the total weight of the composition.
7. A method of non-therapeutically retarding and/or reducing the irritation of lactic acid to skin, said method comprising the steps of: using a composition comprising both high concentration lactic acid and tara gum;
the amount of the tara gum is 0.05 to 2.0wt% based on the total weight of the composition; the amount of high concentration lactic acid is selected from: 10wt% or 5wt%.
8. The method of claim 7, wherein 0.05 to 1.5wt% is based on the total weight of the composition.
9. The method of claim 7, wherein the amount of tara gum is from 0.07 to 1.7wt%, based on the total weight of the composition.
10. The method of claim 9, wherein the amount of tara gum is from 0.1% to 1% wt% by weight of the total composition.
11. The method of claim 10, wherein the amount of tara gum is from 0.1 to 0.8wt% based on the total weight of the composition.
12. The method of claim 7, wherein the composition is a skin care and/or cosmetic.
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| CN113041193A (en) * | 2021-03-26 | 2021-06-29 | 北京东方淼森生物科技有限公司 | Anti-irritation composition and preparation method and application thereof |
| CN113693986A (en) * | 2021-09-13 | 2021-11-26 | 广州筱蔻生物科技有限公司 | Sensitive skin soothing composition, preparation method and application |
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| CN113041193A (en) * | 2021-03-26 | 2021-06-29 | 北京东方淼森生物科技有限公司 | Anti-irritation composition and preparation method and application thereof |
| CN113693986A (en) * | 2021-09-13 | 2021-11-26 | 广州筱蔻生物科技有限公司 | Sensitive skin soothing composition, preparation method and application |
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