CN112957308A

CN112957308A - Composition with anti-allergy, anti-inflammatory and relieving effects, and preparation method and application thereof

Info

Publication number: CN112957308A
Application number: CN202110192537.2A
Authority: CN
Inventors: 赵廷波; 郑潮森
Original assignee: Guangzhou Yujin Trading Co ltd; Guangdong Jiameng Cosmetics Co ltd
Current assignee: Guangzhou Yujin Trading Co ltd; Guangdong Jiameng Cosmetics Co ltd
Priority date: 2021-02-20
Filing date: 2021-02-20
Publication date: 2021-06-15

Abstract

The invention discloses a composition with anti-allergy, anti-inflammatory and relieving effects, and a preparation method and application thereof, wherein the composition comprises, by mass, 5-30% of lactobacillus/soybean milk fermentation product filtrate, 5-25% of kava extract, 0.5-5% of dipotassium glycyrrhizinate, 5-25% of oat kernel extract, 1-5% of glycerol glucoside, and the balance of a solvent. The invention starts from the aspects of recovering the skin micro-ecological barrier, recovering the skin physical barrier, tranquilizing the nerves, relaxing and inhibiting inflammation and the like from multiple angles, and achieves the effects of anti-allergy, anti-inflammation and relaxing.

Description

Composition with anti-allergy, anti-inflammatory and relieving effects, and preparation method and application thereof

Technical Field

The invention relates to the technical field of skin care, in particular to a composition with anti-allergy, anti-inflammatory and soothing effects, and a preparation method and application thereof.

Background

Sensitive skin is a syndrome of discomfort symptoms (including stinging, burning, pain, itching, and tingling) to stimuli that do not normally cause a feeling of discomfort. In recent years, the incidence of sensitive skin has been on the rise year by year and is also receiving more and more attention. The causes of sensitive skin may include: barrier function impairment, sensory nerve dysfunction in the skin, inflammatory response, and the like.

Many anti-allergy products are currently on the market, and most of them are anti-allergy products in terms of inhibition of NO, TNF- α, PGE2, interleukins, leukotrienes and histamine, but these products only inhibit allergy, but are insufficient for sensitive skin.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a composition with anti-allergy, anti-inflammatory and relieving effects, a preparation method and application thereof, and the composition is started from the aspects of restoring skin micro-ecological barriers, restoring skin physical barriers, tranquilizing nerves, relieving and inhibiting inflammation and the like from multiple angles to achieve the anti-allergy, anti-inflammatory and relieving effects.

In order to achieve the purpose, the invention adopts the following technical scheme:

a composition with anti-allergic, anti-inflammatory and relieving effects comprises (by weight) lactobacillus/soybean milk fermentation product filtrate 5-30%, kava extract 5-25%, dipotassium glycyrrhizinate 0.5-5%, oat kernel extract 5-25%, glycerol glucoside 1-5%, and solvent in balance.

Further, in the above composition, the solvent is deionized water.

The invention also provides a preparation method of the composition with anti-allergy, anti-inflammatory and relieving effects, which comprises the following steps:

mixing the lactobacillus/soybean milk fermentation product filtrate, kava extract, dipotassium glycyrrhizinate, oat kernel extract, glycerol glucoside and solvent at normal temperature, and stirring uniformly to obtain the composition with anti-allergy, anti-inflammatory and relieving effects.

The composition with anti-allergy, anti-inflammatory and soothing effects is used for preparing cosmetics, so that the cosmetics have anti-allergy, anti-inflammatory and soothing functions.

The invention has the beneficial effects that: the composition provided by the invention has good anti-allergy, anti-inflammatory and soothing effects on skin. The lactobacillus/soybean milk fermentation product filtrate adopts a unique human bionics fermentation technology to obtain LF 16-35 probiotic metabolites, wherein the metabolites contain more than 300 active ingredients, and the lactobacillus/soybean milk fermentation product filtrate has the effects of improving the quality and diversity of skin microorganisms, protecting a skin acid mask, adjusting the pH value of the skin, keeping the microecological balance on the surface of the skin, reducing anaphylactic reaction, improving the water content of the skin and enhancing the elasticity of the skin. Kava extract is derived from the traditional medicinal plant Piper methysticum in Valley of Polynesia, is rich in kavalactones, has triple effects of immediate sedation, anti-inflammatory, and antibacterial, and can instantaneously relieve skin sensitivity. The dipotassium glycyrrhizinate is a derivative of glycyrrhizic acid, and can eliminate skin inflammation and allergy symptoms such as skin redness, edema, pruritus, pain, fever and the like by inhibiting the activity of hyaluronidase and the release of histamine. The oat kernel extract is derived from active ingredients of natural oat kernels, and has powerful comprehensive activities of resisting inflammation, relieving itching, resisting histamine, resisting erythema, reducing inflammatory factors IL-6 and IL-8 and the like. Glycerol glucoside is a multifunctional cell activator, can activate aquaporin-3 and filaggrin, stabilize the moisture content of the skin to achieve the moisturizing effect, restore the skin barrier, prevent the generation of inflammation by inhibiting the formation of cytokines, and protect keratinocytes from being damaged by ultraviolet rays.

Detailed Description

The present invention will be further described below, and it should be noted that the present embodiment is based on the technical solution, and a detailed implementation manner and a specific operation process are provided, but the protection scope of the present invention is not limited to the present embodiment.

Example 1

A composition with anti-allergy, anti-inflammatory and soothing effects comprises, by mass, 5% of lactobacillus/soybean milk fermentation product filtrate, 5% of kava extract, 0.5% of dipotassium glycyrrhizinate, 5% of oat kernel extract, 1% of glycerol glucoside, and the balance of deionized water.

Example 2

A composition with anti-allergic, anti-inflammatory and soothing effects comprises lactobacillus/soybean milk fermentation product filtrate 30%, kava extract 25%, dipotassium glycyrrhizinate 5%, oat kernel extract 25%, glycerol glucoside 5%, and deionized water in balance.

Example 3

A composition with anti-allergic, anti-inflammatory and soothing effects comprises 25% lactobacillus/soybean milk fermentation product filtrate, 20% kava extract, 3.5% dipotassium glycyrrhizinate, 15% oat kernel extract, 3% glycerol glucoside, and the balance deionized water.

Example 4

This example provides a method of preparing the anti-allergic, anti-inflammatory, and soothing compositions of examples 1-3, comprising the steps of:

Example 5

This example provides a method for preparing a lotion containing the composition having anti-allergy, anti-inflammatory and soothing effects described in example 2 (referred to as composition in table 1 for short). The other components contained in the astringent are shown in table 1.

TABLE 1

Phase (C)	Components	Adding amount (percentage)
			A	Deionized water	To 100
A	EDTA disodium salt	0.10
			A	Glycerol	3.00
A	Polyglycerol-10	2.00
			A	Methyl propylene glycol	3.00
A	Sclerotium rolfsii gum	0.15
			B	Composition comprising a metal oxide and a metal oxide	6.00
C	Polysorbate-20	0.20
			C	Essence	Small amount of
C	Preservative	Small amount of

The preparation process comprises the following steps:

heating the phase A to 85 ℃, preserving heat for 15 minutes and stirring until the phase A is completely dissolved; cooling to 45 ℃, adding the phase B and stirring uniformly; and C, mixing, adding, stirring for 15 minutes, and discharging.

Example 6

This example provides a method for preparing an emulsion containing the anti-allergic, anti-inflammatory, and soothing composition described in example 2 (referred to in Table 2 as the composition). The other components contained in the emulsion are shown in table 2.

TABLE 2

The preparation method comprises the following specific processes:

heating phase A to 85 deg.C to dissolve completely; heating phase B to 85 deg.C to dissolve; adding the phase B into the phase A, homogenizing and stirring for 3 ', cooling to 65 ℃, adding the phase C, and homogenizing for 30'; continuously stirring and cooling to 45 ℃, adding the D phase and the E phase, stirring for 30', detecting to be qualified, and discharging.

Example 7

This example provides a method of making a cream containing the anti-allergy, anti-inflammatory and soothing composition of example 3 (referred to in Table 3 for brevity). The other components contained in the cream are shown in table 3.

TABLE 3

The preparation method comprises the following specific processes:

Comparative example 1:

the present comparative example provides a process for the preparation of an emulsion without the composition having anti-allergy, anti-inflammatory and soothing action. The components of the emulsion are shown in table 4.

TABLE 4

The preparation method comprises the following specific processes:

heating phase A to 85 deg.C to dissolve completely; heating phase B to 85 deg.C to dissolve; adding the phase B into the phase A, homogenizing and stirring for 3 ', cooling to 65 ℃, adding the phase C, and homogenizing for 30'; and continuously stirring, cooling to 45 ℃, adding the phase D, stirring for 30', detecting to be qualified, and discharging.

Example 6 and comparative example 1 were tested and evaluated.

Grouping experiments: 30 sensitive skin groups, different ages and different sexes are screened for the experimental group and the blank group respectively. The experimental group was the application of the emulsion product prepared in preparation example 6, and the blank group was the application of the emulsion product prepared in comparative example 1. Half face test, respectively, the test subjects tested the effect for 7 days, 14 days and 30 days, respectively.

Evaluation criteria:

the four aspects of pain, redness, itching and skin desquamation common to allergic people were evaluated. The number of people with four completely disappeared symptoms was counted.

As can be seen from the results, the experimental group containing the composition having anti-allergy, anti-inflammatory and soothing effects had rapid and effective anti-pain, redness-relieving, itching-relieving and skin barrier-repairing functions.

Various corresponding changes and modifications can be made by those skilled in the art based on the above technical solutions and concepts, and all such changes and modifications should be included in the protection scope of the present invention.

Claims

1. A composition with anti-allergy, anti-inflammatory and soothing effects is characterized by comprising 5-30% of lactobacillus/soybean milk fermentation product filtrate, 5-25% of kava extract, 0.5-5% of dipotassium glycyrrhizinate, 5-25% of oat kernel extract, 1-5% of glycerol glucoside and the balance of solvent by mass percentage.

2. The anti-allergic, anti-inflammatory, and soothing composition as claimed in claim 1, wherein the solvent is deionized water.

3. A process for the preparation of a composition having anti-allergic, anti-inflammatory and soothing effects as claimed in any one of claims 1-2, comprising the steps of:

4. Use of a composition according to any of claims 1-2 having anti-allergy, anti-inflammatory and soothing effects for the preparation of a cosmetic product.