CN113768859A - Oral and external composition for improving sensitive skin and application thereof - Google Patents
Oral and external composition for improving sensitive skin and application thereof Download PDFInfo
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- CN113768859A CN113768859A CN202110696494.1A CN202110696494A CN113768859A CN 113768859 A CN113768859 A CN 113768859A CN 202110696494 A CN202110696494 A CN 202110696494A CN 113768859 A CN113768859 A CN 113768859A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Abstract
The invention relates to the technical field of skin care products, in particular to an oral and external composition for improving sensitive skin and application thereof. The oral and external composition comprises an oral probiotic composition and an external skin care composition. The oral composite probiotics is combined with the external specific skin care product, so that a combined skin treatment scheme combining oral administration and external application is provided, the discomfort of sensitive muscles can be effectively relieved, and the oral composite probiotics skin care product has obvious effects on intestinal physiological balance, skin conditioning, repair, allergy resistance and skin resistance improvement; meanwhile, the external skin care product has strong stability and wide temperature resistance, can be stored for a long time to exert the effect, and is suitable for being widely popularized in the field of cosmetics.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to an oral and external composition for improving sensitive skin and application thereof.
Background
With the improvement of national quality of life, consumers increasingly attach importance to the life style of health preservation and pursue internal and external sensory experiences. Sensitive skin refers to a type of problematic skin that is easily subject to skin intolerance under external stimuli, is highly sensitive to physical (e.g., temperature, ultraviolet, humidity, wind speed, etc.) or chemical stimuli (e.g., corrosive chemicals, air pollutants, smoke, etc.), and is unstable and uncomfortable after receiving external sensitization signals, such as redness, peeling, dryness, tightness, itching, acne, even redness and swelling, pain, etc., which are essentially caused by the fact that the sebum membrane and the horny layer are damaged and the skin barrier cannot provide sufficient protection.
The existing research finds that the factors causing the skin sensitivity are not only external reasons, but also the physiological balance in the body is an important factor influencing the skin state; recent scientific studies have shown that the patch of gut microbiome causes a change in the immune response and leads to the development of atopic dermatitis, and it has been further explored that the stability of gut microbiome is closely related to the homeostasis and ectopic metabolism of the skin. Based on the above, the adjustment of the intestinal flora state provides a brand new idea for improving and treating sensitive skin; the technical blind area of the field of skin care products is the combination of the scheme of regulating the intestinal health of organisms and conditioning the skin by external application. Under such circumstances, exploring a method for improving sensitive muscles that organically combines internal modulation with external application becomes an urgent problem to be solved in the art.
Disclosure of Invention
The invention provides an oral and external composition for improving sensitive skin, solves the problems that a skin care product in the prior art has poor repairing effect on the sensitive skin and skin problems are difficult to eradicate, and realizes the oral and external composition for improving the sensitive skin.
The invention provides an internal and external composition for improving sensitive skin, which comprises an oral probiotic composition and an external skin care composition.
In a preferred embodiment, the oral probiotic composition is at least 2 of lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus helveticus, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve, bifidobacterium adolescentis, lactobacillus bulgaricus, lactobacillus acidophilus, lactobacillus casei, streptococcus thermophilus, lactobacillus reuteri.
In a preferred embodiment, the oral probiotic composition is lactobacillus paracasei, lactobacillus rhamnosus and lactobacillus helveticus.
In a preferred embodiment, the weight ratio of lactobacillus paracasei, lactobacillus rhamnosus and lactobacillus helveticus is (40-60): (15-25): (0.5-4).
In a preferred embodiment, the oral probiotic composition further comprises a polysaccharide; the polysaccharide comprises at least one of maltodextrin, starch, cellulose, glycogen, gum arabic, chitin, hyaluronic acid, and chondroitin sulfate.
In a preferred embodiment, the topical skin care composition comprises probiotic fermentation products, ceramides, polysaccharide components, plant extracts.
In a preferred embodiment, the external skin care composition comprises 0.5-4 parts of probiotic fermentation product, 1.5-5 parts of ceramide, 0.1-10 parts of polysaccharide component and 0-6 parts of plant extract in parts by weight.
In a preferred embodiment, the plant extract comprises at least one of kava extract, chamomile extract, squalane, rose hip oil, annatto oil, citrus peel extract, purslane extract, tea tree essential oil, calendula extract.
In a preferred embodiment, the probiotic fermentation product is in particular: inoculating lactobacillus and Bacillus bifidus into Japanese black soybean milk, fermenting at 37 deg.C for 120 hr, filtering, and collecting filtrate to obtain lactobacillus/soybean milk fermented product filtrate; and mixing the lactobacillus/soybean milk fermentation product filtrate with water, butanediol and 1, 2-pentanediol to obtain the probiotic fermentation product.
The second aspect of the invention provides application of an oral and external composition for improving sensitive skin, and the oral and external composition is applied to repair and treatment of problem skin.
Has the advantages that:
the oral composite probiotics is combined with the external specific skin care product, so that a combined skin treatment scheme combining oral administration and external application is provided, the discomfort of sensitive muscles can be effectively relieved, and the oral composite probiotics skin care product has obvious effects on intestinal physiological balance, skin conditioning, repair, allergy resistance and skin resistance improvement; meanwhile, the external skin care product has strong stability and wide temperature resistance, can be stored for a long time to exert the effect, and is suitable for being widely popularized in the field of cosmetics.
Detailed Description
In order to solve the above problems, the present invention provides, in a first aspect, an oral and external composition for improving sensitive skin, the oral and external composition comprising an oral probiotic composition and an external skin care composition.
In some preferred embodiments, the oral probiotic composition is at least 2 of lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus helveticus, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve, bifidobacterium adolescentis, lactobacillus bulgaricus, lactobacillus acidophilus, lactobacillus casei, streptococcus thermophilus, lactobacillus reuteri.
In some preferred embodiments, the oral probiotic composition is lactobacillus paracasei, lactobacillus rhamnosus and lactobacillus helveticus.
In some preferred embodiments, the weight ratio of lactobacillus paracasei, lactobacillus rhamnosus and lactobacillus helveticus is (40-60): (15-25): (0.5-4).
In some preferred embodiments, the oral probiotic composition further comprises a polysaccharide; the polysaccharide comprises at least one of maltodextrin, starch, cellulose, glycogen, gum arabic, chitin, hyaluronic acid, and chondroitin sulfate.
Further preferably, the oral probiotic composition is 50 wt% of lactobacillus paracasei, 19 wt% of lactobacillus rhamnosus and 1 wt% of lactobacillus helveticus and 30 wt% of maltodextrin.
The oral probiotic composition is sold as Xiandheng Yisheng solid beverage and is sourced from Xianting (Guangzhou) trade company Limited. The Xianhengyu probiotic solid beverage has the specification of 1KG, and has the performance of promoting nutrient absorption and keeping intestinal health by adjusting the immune function of a host mucous membrane and a system or by adjusting the balance of flora in intestinal tracts; from xiantang (guangzhou) trade company ltd.
Preferably, the oral probiotic composition is taken in an empty stomach of 200-400 mg before breakfast and dinner every day.
In some preferred embodiments, the topical skin care composition includes a probiotic fermentation product, a ceramide, a polysaccharide component, a plant extract.
In some preferred embodiments, the external skin care composition comprises 0.5-4 parts by weight of probiotic fermentation product, 1.5-5 parts by weight of ceramide, 0.1-10 parts by weight of polysaccharide component and 0-6 parts by weight of plant extract.
In some preferred embodiments, the plant extract comprises at least one of kava extract, chamomile extract, squalane, rose hip oil, annatto oil, citrus peel extract, purslane extract, tea tree essential oil, calendula extract.
In some preferred embodiments, the probiotic fermentation product is in particular: inoculating lactobacillus and Bacillus bifidus into Japanese black soybean milk, fermenting at 37 deg.C for 120 hr, filtering, and collecting filtrate to obtain lactobacillus/soybean milk fermented product filtrate; and mixing the lactobacillus/soybean milk fermentation product filtrate with water, butanediol and 1, 2-pentanediol to obtain the probiotic fermentation product.
The probiotic fermentation product has the trade name of baiting and is sourced from Xianting (Guangzhou) trade company Limited. The oxitenmin is 100g in size and is a multifunctional soothing agent obtained from fermented soybean milk and is sourced from xiantang (guangzhou) trade company Limited.
In some preferred embodiments, the ceramide-like starting material comprises: 25-30% of macadamia integrifolia seed oil, 20-25% of phospholipid, 10-15% of wild soybean sterol stearic acid, 5-10% of safflower oil/palm oil amino propylene glycol ester, 5-10% of squalane and 10-15% of glycerol.
The commercial name of the ceramide is ceramide MIX, the specification is 5KG, the performance is immediate and lasting barrier repair effect, and the ceramide is sourced from Xianting (Guangzhou) trade company Limited.
Examples of polysaccharide components include, but are not limited to, ecological nutritional solutions, rhamnose-soothing agents, and biopolysaccharide gum-1.
In some preferred embodiments, the ecological nutrient solution comprises 50-70 wt% of inulin, 10-20 wt% of glucan oligosaccharide, and the balance of water.
The inulin is extract of chicory root (Cichorium glaandulosum Boiss).
Further preferably, the ecological nutrient solution comprises 60 wt% of inulin, 15 wt% of glucan oligosaccharide and the balance of water supplement. The ecological nutrient solution has the specification of 25KG, has the performance of regulating skin microbiome and providing skin immunity, and is sourced from Xianting (Guangzhou) trade company Limited.
The rhamnose soothing agent is sold under the trade name of RHAMINOSOFT HP 1.5P, has the specification of 5KG, has the performance of limiting the release of inflammatory messengers from keratinocytes to reduce inflammation, and is sourced from Xiantin (Guangzhou) trade company Limited.
The biological polysaccharide gum-1 is a mixture of L-fucose, D-galactose and galacturonic acid; when used, the product can be made into various dosage forms such as biopolysaccharide gum-1 POWDER (trade name: FUCOGEL POWDER, specification: 2KG) or biopolysaccharide gum-1 aqueous solution (trade name: FUCOGEL 1.5P, specification: 25KG), which has the effects of affecting the communication of keratinocytes and nerve cells to promote protein synthesis, and regulating skin inflammation and pain, and is originated from XIANTING (Guangzhou) trade company Limited.
The probiotics promote the nutrient absorption of human body and keep the intestinal tract healthy by adjusting the immune function of host mucous membrane and system or by adjusting the flora balance in the intestinal tract; based on the influence of intestinal health on the overall function of a human body, the probiotics also have the potential function of treating skin diseases. According to the invention, through experimental researches, the lactobacillus paracasei, the lactobacillus rhamnosus and the lactobacillus helveticus are adopted as the oral probiotic composition to act together, so that the physical barrier of an intestinal tract resisting pathogens can be increased, the growth of the intestinal tract pathogens can be inhibited, the immune response of an organism can be enhanced, the proinflammatory cytokine can be inhibited, and the skin homeostasis can be recovered; the specific oral probiotic composition and the external skin care composition are adopted to act, so that the skin sensitivity can be obviously reduced, and the barrier repair can be improved. Further researches show that the maltodextrin is added on the basis of the 3 probiotic compositions, can effectively load probiotics into human intestinal tracts, promotes the interaction of the probiotics with intestinal epithelium and immune cells to release immune media, regulates the balance of intestinal flora, further improves the recovery rate of skin barrier function, effectively resists skin sensitivity and inflammation and improves the skin resistance.
On the basis of regulating the intestinal microbial balance by adopting the oral probiotic composition, the invention further adopts the cooperation of the external skin care composition to improve the skin state from the external dimension and the internal dimension. In the prior art, food prebiotics cannot act on skin flora, most probiotic cosmetics are inactivated bacteria, the activity of protein is difficult to maintain in cosmetic varieties, and probiotic fermentation products can play a role in skin, have stable efficacy, are not influenced by factors such as ecological flora and the like, and are effective methods for introducing probiotics into cosmetic formulas. The invention adopts lactobacillus and bifidobacterium to inoculate in Japanese black soybean milk, and the metabolite is obtained by fermentation under bionic conditions, on one hand, the permeability of the skin is improved, the rapid and effective absorption of active factors by the skin is promoted, on the other hand, the natural extract is converted into a more stable and efficient compound, the potential damage of substances such as aflatoxin and the like to the skin is inhibited, microbial, chemical, physical and biological multiple barriers are provided for the skin, the quality and diversity of skin microorganisms are improved, the skin is maintained to be in a healthy weak acid pH, the skin inflammation and the stress reaction caused by external stimulation are improved, and simultaneously, the lactobacillus and bifidobacterium are compounded with substances such as specific ceramide, specific saccharide components, rhamnose soothing agent and the like to play a role in promoting the synthesis of skin recombination units such as collagen, hyaluronic acid and the like, repairing the loss of skin lipid, and activating the innate immune defense system of the skin, reducing irritation, erythema, desquamation, roughness and dryness of diseased skin, and improving skin hydration. The external skin care composition composed of the raw materials can play a synergistic interaction role with the oral probiotic composition, and has remarkable effects of improving sensitive skin and improving skin tolerance.
The second aspect of the invention provides application of an oral and external composition for improving sensitive skin, and the oral and external composition is applied to repair and treatment of problem skin.
In some preferred embodiments, the skin care composition for external use provided by the present invention can be added to various cosmetic formulations to exert skin care effects, such as night cream, essence, cream, mask, toner, cleanser, etc.
Examples in order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.
Example 1.
The embodiment provides an internal and external composition for improving sensitive skin, which comprises an oral probiotic composition and an external skin care composition.
The oral probiotic composition comprises 50 wt% of lactobacillus paracasei, 19 wt% of lactobacillus rhamnosus, 1 wt% of lactobacillus helveticus and 30 wt% of maltodextrin.
The oral probiotic composition is sold as Xiandheng Yisheng solid beverage and is sourced from Xianting (Guangzhou) trade company Limited. The Xianhengyu probiotic solid beverage has the specification of 1KG, and has the performance of promoting nutrient absorption and keeping intestinal health by adjusting the immune function of a host mucous membrane and a system or by adjusting the balance of flora in intestinal tracts; from xiantang (guangzhou) trade company ltd.
The oral probiotic composition is administered in an amount of 400mg daily before breakfast and dinner on an empty stomach.
The external skin care composition comprises, by weight, 2 parts of probiotic fermentation products, 2.5 parts of ceramide, 5 parts of polysaccharide components and 2 parts of plant extracts.
The plant extract is green olive squalane, and is sourced from Xianting (Guangzhou) trade company Limited.
The probiotic fermentation product specifically comprises: inoculating lactobacillus and Bacillus bifidus into Japanese black soybean milk, fermenting at 37 deg.C for 120 hr, filtering, and collecting filtrate to obtain lactobacillus/soybean milk fermented product filtrate; and mixing the lactobacillus/soybean milk fermentation product filtrate with water, butanediol and 1, 2-pentanediol to obtain the probiotic fermentation product.
The probiotic fermentation product has the trade name of baiting and is sourced from Xianting (Guangzhou) trade company Limited. The oritminmin is 20KG in specification, and the performance is multifunctional soothing agent obtained from fermented soybean milk and is sourced from Xiantin (Guangzhou) trade company Limited.
The raw materials of the ceramide comprise: 25-30% of macadamia integrifolia seed oil, 20-25% of phospholipid, 10-15% of wild soybean sterol stearic acid, 5-10% of safflower oil/palm oil amino propylene glycol ester, 5-10% of squalane and 10-15% of glycerol.
The commercial name of the ceramide is ceramide MIX, the specification is 5KG, the performance is immediate and lasting barrier repair effect, and the ceramide is sourced from Xianting (Guangzhou) trade company Limited.
The polysaccharide components comprise ecological nutrient solution, rhamnose soothing agent and biological polysaccharide gum-1 aqueous solution; the weight ratio of the rhamnose moderator to the biological polysaccharide gum-1 aqueous solution of the ecological nutrient solution is 1: 3: 1.
the ecological nutrient solution comprises 60 wt% of inulin, 15 wt% of glucan oligosaccharide and the balance of water supplement. The ecological nutrient solution has the specification of 25KG, has the performance of regulating skin microbiome and providing skin immunity, and is sourced from Xianting (Guangzhou) trade company Limited.
The inulin is extract of chicory root (Cichorium glaandulosum Boiss).
The rhamnose soothing agent has a model of rhamsoft HP 1.5P and a specification of 5KG, has the performance of limiting the release of inflammatory messengers from keratinocytes to reduce inflammation, and is sourced from xiantong (guangzhou) trade company ltd.
The biological polysaccharide gum-1 is a mixture of L-fucose, D-galactose and galacturonic acid; when in use, the trade name of the aqueous solution of the biological polysaccharide gum-1 is as follows: FUCOGEL 1.5P with a specification of 25KG has the properties of affecting the communication of keratinocytes and nerve cells to promote protein synthesis and regulate skin inflammation and pain, and is sourced from Xianting (Guangzhou) trade company Limited.
Example 2.
The embodiment provides an internal and external composition for improving sensitive skin, which comprises an oral probiotic composition and an external skin care composition.
The oral probiotic composition comprises 50 wt% of lactobacillus paracasei, 19 wt% of lactobacillus rhamnosus, 1 wt% of lactobacillus helveticus and 30 wt% of maltodextrin.
The oral probiotic composition is sold as Xiandheng Yisheng solid beverage and is sourced from Xianting (Guangzhou) trade company Limited. The Xianhengyu probiotic solid beverage has the specification of 1KG, and has the performance of promoting nutrient absorption and keeping intestinal health by adjusting the immune function of a host mucous membrane and a system or by adjusting the balance of flora in intestinal tracts; from xiantang (guangzhou) trade company ltd.
The oral probiotic composition is administered in an amount of 400mg daily before breakfast and dinner on an empty stomach.
The external skin care composition comprises, by weight, 4 parts of probiotic fermentation products, 5 parts of ceramide, 9 parts of polysaccharide components and 6 parts of plant extracts.
The plant extract is green olive squalane, and is sourced from Xianting (Guangzhou) trade company Limited.
The probiotic fermentation product specifically comprises: inoculating lactobacillus and Bacillus bifidus into Japanese black soybean milk, fermenting at 37 deg.C for 120 hr, filtering, and collecting filtrate to obtain lactobacillus/soybean milk fermented product filtrate; and mixing the lactobacillus/soybean milk fermentation product filtrate with water, butanediol and 1, 2-pentanediol to obtain the probiotic fermentation product.
The probiotic fermentation product has the trade name of baiting and is sourced from Xianting (Guangzhou) trade company Limited. The oritminmin is 20KG in specification, and the performance is multifunctional soothing agent obtained from fermented soybean milk and is sourced from Xiantin (Guangzhou) trade company Limited.
The raw materials of the ceramide comprise: 25-30% of macadamia integrifolia seed oil, 20-25% of phospholipid, 10-15% of wild soybean sterol stearic acid, 5-10% of safflower oil/palm oil amino propylene glycol ester, 5-10% of squalane and 10-15% of glycerol.
The commercial name of the ceramide is ceramide MIX, the specification is 5KG, the performance is immediate and lasting barrier repair effect, and the ceramide is sourced from Xianting (Guangzhou) trade company Limited.
The polysaccharide components comprise ecological nutrient solution, rhamnose soothing agent and biological polysaccharide gum-1 aqueous solution; the weight ratio of the rhamnose moderator to the biological polysaccharide gum-1 aqueous solution of the ecological nutrient solution is 1: 3: 1.
the ecological nutrient solution comprises 60 wt% of inulin, 15 wt% of glucan oligosaccharide and the balance of water supplement. The ecological nutrient solution has the specification of 25KG, has the performance of regulating skin microbiome and providing skin immunity, and is sourced from Xianting (Guangzhou) trade company Limited.
The inulin is extract of chicory root (Cichorium glaandulosum Boiss).
The rhamnose soothing agent has a model of rhamsoft HP 1.5P and a specification of 5KG, has the performance of limiting the release of inflammatory messengers from keratinocytes to reduce inflammation, and is sourced from xiantong (guangzhou) trade company ltd.
The biological polysaccharide gum-1 is a mixture of L-fucose, D-galactose and galacturonic acid; when in use, the trade name of the aqueous solution of the biological polysaccharide gum-1 is as follows: FUCOGEL 1.5P with a specification of 25KG has the properties of affecting the communication of keratinocytes and nerve cells to promote protein synthesis and regulate skin inflammation and pain, and is sourced from Xianting (Guangzhou) trade company Limited.
Example 3.
The embodiment provides an internal and external composition for improving sensitive skin, which comprises an oral probiotic composition and an external skin care composition.
The oral probiotic composition comprises 50 wt% of lactobacillus paracasei, 19 wt% of lactobacillus rhamnosus, 1 wt% of lactobacillus helveticus and 30 wt% of maltodextrin.
The oral probiotic composition is sold as Xiandheng Yisheng solid beverage and is sourced from Xianting (Guangzhou) trade company Limited. The Xianhengyu probiotic solid beverage has the specification of 1KG, and has the performance of promoting nutrient absorption and keeping intestinal health by adjusting the immune function of a host mucous membrane and a system or by adjusting the balance of flora in intestinal tracts; from xiantang (guangzhou) trade company ltd.
The oral probiotic composition is administered in an amount of 400mg daily before breakfast and dinner on an empty stomach.
The external skin care composition comprises, by weight, 1 part of probiotic fermentation product, 1.5 parts of ceramide, 2 parts of polysaccharide component and 0.8 part of plant extract.
The plant extract is green olive squalane, and is sourced from Xianting (Guangzhou) trade company Limited.
The probiotic fermentation product specifically comprises: inoculating lactobacillus and Bacillus bifidus into Japanese black soybean milk, fermenting at 37 deg.C for 120 hr, filtering, and collecting filtrate to obtain lactobacillus/soybean milk fermented product filtrate; and mixing the lactobacillus/soybean milk fermentation product filtrate with water, butanediol and 1, 2-pentanediol to obtain the probiotic fermentation product.
The probiotic fermentation product has the trade name of baiting and is sourced from Xianting (Guangzhou) trade company Limited. The oritminmin is 20KG in specification, and the performance is multifunctional soothing agent obtained from fermented soybean milk and is sourced from Xiantin (Guangzhou) trade company Limited.
The raw materials of the ceramide comprise: 25-30% of macadamia integrifolia seed oil, 20-25% of phospholipid, 10-15% of wild soybean sterol stearic acid, 5-10% of safflower oil/palm oil amino propylene glycol ester, 5-10% of squalane and 10-15% of glycerol.
The commercial name of the ceramide is ceramide MIX, the specification is 5KG, the performance is immediate and lasting barrier repair effect, and the ceramide is sourced from Xianting (Guangzhou) trade company Limited.
The polysaccharide components comprise ecological nutrient solution, rhamnose soothing agent and biological polysaccharide gum-1 aqueous solution; the weight ratio of the rhamnose moderator to the biological polysaccharide gum-1 aqueous solution of the ecological nutrient solution is 1: 3: 1.
the ecological nutrient solution comprises 60 wt% of inulin, 15 wt% of glucan oligosaccharide and the balance of water supplement. The ecological nutrient solution has the specification of 25KG, has the performance of regulating skin microbiome and providing skin immunity, and is sourced from Xianting (Guangzhou) trade company Limited.
The inulin is extract of chicory root (Cichorium glaandulosum Boiss).
The rhamnose soothing agent has a model of rhamsoft HP 1.5P and a specification of 5KG, has the performance of limiting the release of inflammatory messengers from keratinocytes to reduce inflammation, and is sourced from xiantong (guangzhou) trade company ltd.
The biological polysaccharide gum-1 is a mixture of L-fucose, D-galactose and galacturonic acid; when in use, the trade name of the aqueous solution of the biological polysaccharide gum-1 is as follows: FUCOGEL 1.5P with a specification of 25KG has the properties of affecting the communication of keratinocytes and nerve cells to promote protein synthesis and regulate skin inflammation and pain, and is sourced from Xianting (Guangzhou) trade company Limited.
Performance test method
Skin roughness:
60 sensitive muscle volunteers (divided into 3 groups of 20 persons each) were selected, and the oral and external composition of examples 1-3 was used in 3 groups, specifically using the following method: taking 400mg of oral probiotic composition before breakfast and dinner with empty stomach every day, cleaning face every morning and night, and applying 2g of topical skin care composition on face; the oral and external composition was continuously used for 60 days, and the roughness of the facial skin was evaluated using an ANTERA 3D skin imaging tester from Miravex corporation; facial skin roughness K before and after use was recorded.
Skin moisture content:
60 sensitive muscle volunteers (divided into 3 groups of 20 persons each) were selected, and the oral and external composition of examples 1-3 was used in 3 groups, specifically using the following method: administering 400mg of oral probiotic composition before breakfast and supper on empty stomach every day, and applying 5g of topical skin care composition to the inner side of forearm after bathing every day; the oral and external composition was used continuously for 28 days, and the water content W of the forearm medial skin before and after 8 hours of use was measured using a moisturmetersc (MSC1001) stratum corneum hydration meter of DELFIN corporation.
Stability;
the external skin care composition prepared in the examples 1 to 3 is used as a sample to be tested, each group of the liquid to be tested is placed at 45 ℃, 25 ℃ and 5 ℃ for 3 hours in sequence, the circulation is performed for 3 times, and the state of the sample to be tested is observed after the liquid to be tested is taken out, so that the phenomena of layering, precipitation and discoloration do not occur in the samples to be tested in the examples 1 to 3.
Performance test data
TABLE 1 Performance test results
Claims (10)
1. The oral and external composition for improving the sensitive skin is characterized by comprising an oral probiotic composition and an external skin care composition.
2. The composition for oral and external use for improving sensitive skin according to claim 1, wherein said probiotic composition for oral administration is at least 2 of lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus helveticus, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve, bifidobacterium adolescentis, lactobacillus bulgaricus, lactobacillus acidophilus, lactobacillus casei, streptococcus thermophilus, lactobacillus reuteri.
3. The composition for oral and external use for improving sensitive skin according to claim 2, wherein the probiotic composition for oral administration is lactobacillus paracasei, lactobacillus rhamnosus and lactobacillus helveticus.
4. The composition for oral and external use for improving sensitive skin according to claim 3, wherein the weight ratio of Lactobacillus paracasei, Lactobacillus rhamnosus and Lactobacillus helveticus is (40-60): (15-25): (0.5-4).
5. The composition for oral and external use for improving sensitive skin according to any one of claims 2 to 4, wherein said oral probiotic composition further comprises a polysaccharide; the polysaccharide comprises at least one of maltodextrin, starch, cellulose, glycogen, gum arabic, chitin, hyaluronic acid, and chondroitin sulfate.
6. The composition for oral and external use for improving sensitive skin according to any one of claims 1 to 5, wherein the skin care composition for external use comprises probiotic fermentation products, ceramides, polysaccharide components, and plant extracts.
7. The composition for oral administration and external use for improving sensitive skin according to claim 6, wherein the composition for external use for skin care comprises, by weight, 0.5 to 4 parts of probiotic fermentation product, 1.5 to 5 parts of ceramide, 0.1 to 10 parts of polysaccharide component, and 0 to 6 parts of plant extract.
8. The composition for oral and external use for improving sensitive skin according to claim 7, wherein the plant extract comprises at least one of kava extract, chamomile extract, oleanolia squalane, rose hip oil, annatto oil, citrus peel extract, purslane extract, tea tree essential oil, and calendula extract.
9. The composition for oral administration and external use for improving sensitive skin according to claim 8, wherein the probiotic fermentation product is specifically: inoculating lactobacillus and Bacillus bifidus into Japanese black soybean milk, fermenting at 37 deg.C for 120 hr, filtering, and collecting filtrate to obtain lactobacillus/soybean milk fermented product filtrate; and mixing the lactobacillus/soybean milk fermentation product filtrate with water, butanediol and 1, 2-pentanediol to obtain the probiotic fermentation product.
10. Use of the composition for oral and external use according to any one of claims 1 to 9 for improving sensitive skin, wherein the composition for oral and external use is applied for the repair and treatment of the skin in question.
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