KR20150096165A - Manufacturing method for cosmetic composition for improving acne and cosmetic compostion thereof - Google Patents

Abstract

The present invention relates to a cosmetic composition for alleviating acne. According to an embodiment of the present invention, a method for producing the cosmetic composition includes the steps of: producing a first mixture including poloxamer, azelaic acid, and water at 35-50°C; adjusting viscosity of the first mixture to be 5,000-50,000 cPs at 35-50°C; and producing a second mixture including the first mixture and tea tree leaves oil at 25-35°C. The poloxamer and the azelaic acid are included at a weight ratio of 1 : 1 to 1 : 5.

Description

TECHNICAL FIELD [0001] The present invention relates to a cosmetic composition for improving acne and a cosmetic composition prepared by the same. BACKGROUND ART [0002]

The present invention relates to a method for producing a cosmetic composition for improving acne and a cosmetic composition prepared thereby. More particularly, the present invention relates to a method for producing a cosmetic composition for improving acne, which is excellent in formulation stability by being dispersed in a specific solvent and is excellent in improving skin troubles such as acne, and a cosmetic composition prepared thereby.

Acne is a chronic, intractable, inflammatory skin disease that occurs in the sebaceous glands around the hair follicles and hair follicles. Although the exact cause of such acne is not known, it is known that the increase in sebum secretion due to hormone abnormalities, follicular stenosis, Reactions are known to be the main causes. Therefore, acne is common on face, scalp, neck, chest, back, upper and shoulders where sebaceous glands are concentrated.

The cause of acne can be divided into three major causes, the first is the overproduction of sebum. In the sexually mature stage, increased acne is caused by hormones, especially testosterone is recognized as the most important hormone, which stimulates the sebaceous glands and increases the production of sebum. Sebum is composed of triglycerol at the initial secretion but gradually decomposed into free fatty acid and glycerol by lipase which is one of the extracellular enzymes of Propionibacterium acnes. Of the free fatty acids in the skin, 95% of these bacteria are responsible for the formation of microfacial tissues and inflammatory responses. These chemical changes break down the pH balance of the skin surface so that the weakly acidic pH of the healthy skin is alkalized, resulting in deterioration of the skin's own function and a vicious cycle of the skin. The extracellular enzymes of Propionibacterium acnes, which provide such a cause, are lipases, proteases, hyaluronidase, and the like, which have an important influence on the progress of acne.

The second is the closure of pores. Due to the exaggeration of the skin and excessive secretion of sebum, which are influenced by the free fatty acids and hormones produced by the action of Propionibacterium acnes, the pustule is closed. As a result, the proliferation of the anaerobic bacterium, Propionibacterium acnes, do.

The third is the increase in the number of anaerobic bacterium, Propionibacterium acnes. When the sebum component is accumulated in a white lump or an oxidized black lump, the amount of propionibacterium acnes is increased.

The three factors mentioned above are the biggest factors causing acne, but other factors such as the action of neuroproteins due to stress, genetic factors, cosmetics, heat, moisture and ultraviolet rays that cause extinction are also related to the occurrence of acne.

The treatment of acne is to reduce sebaceous glands, soften hair follicles and keratin so that they do not harden, reduce germs in hair follicles, and prevent acne from developing into inflammation.

On the other hand, the therapeutic agent for acne is divided into a topical treatment to be directly applied to lesions and a systemic treatment to take medicines. Local or systemic treatments are used singly or in combination according to the type of acne and each step. Examples of topical treatments include synthetic vitamin A ointment, benzoyl peroxide, antibiotic ointment, steroid ointment, and azelaic acid. Oral antibiotics, hormones, and synthetic vitamin A preparations are used for systemic treatment .

Antimicrobials such as erythromycin and anti-inflammation ingredients for treatment of inflammation and hormone preparations for controlling sebum are used for the removal of acne bacteria, but they are mainly used in the pharmaceutical field. Recently, However, the materials such as salicylic acid, tricoloric acid, retinoic acid, and nisin used in these cosmetic products are excellent in antimicrobial effect of the raw material itself, but it is difficult to limit the formulation and effectively apply the cosmetic material in cosmetic formulations There were disadvantages.

On the other hand, Azelaic acid is a saturated dicarboxylic acid having 9 carbon atoms and has an effect of inhibiting the proliferation of bacteria of Propionibacterium acnes and Staphylococcus epidermidis in the hair follicles , Mitigates skin pigmentation, eliminates unnecessary keratinocytes and has a comedolytic effect on acne skin, and has recently been attracting attention as an acne improvement, relief, and therapeutic ingredient. However, when applied to cosmetic formulations, azelaic acid has many problems in its use due to its structural characteristics. That is, it has a property that it is insoluble in water and oil, and when micro emulsion is dispersed, it precipitates at low temperature and skin irritation occurs when it is used at high concentration.

At present, products using azelaic acid are made into microemulsion form after being dispersed in polyhydric alcohol such as polyethylene glycol (PEG). Since these products are large in size, they are often found in the case of long-term storage, and the feeling of use is decreased due to stickiness. As a result, the affinity to the skin is lowered and skin tingling and tingling appear. In severe cases, inflammation is produced. Despite its high concentration, its efficacy was low.

In Korean Patent Publication No. 2012-0132067, a mixture containing azelaic acid and skimmed milk powder is lyophilized and pulverized, and the pulverized nano powder is coated with a corn protein coating solution to be nano-encapsulated to provide acne treatment having excellent penetration effect at low concentration A cosmetic composition composition is disclosed.

On the other hand, poloxamer (polyoxyethylene-polyoxypropylene triblock copolymer, poly (oxyethylene) -poly (oxypropylene) -poly (oxyethylene) [POE-POP-POE] triblock copolymer) And the viscosity of the polymer increases as the gelation temperature rises above the gelation temperature. The poloxamer has an excellent surfactant property due to an amphiphilic structure, thereby improving the water solubility of hydrophobic and oil-soluble materials , Or to improve the miscibility of two or more kinds of materials having different hydrophobicity. There are various kinds of these poloxamers depending on the molecular weight and content of polyoxypropylene, and currently, solubilizing agents, emulsifying agents And wetting agents, etc. It is also widely used in various industries such as continuous formulations for sustained release of drugs at the burn site, ophthalmic solvents, injecting agents and anticancer drugs And so on.

On the other hand, Golden thread (Coptis chinensis) is a safe plant that has been used in herbal medicine for a long time since it has been used as a medicinal substance in the rootstock of a perennial herbaceous plant such as Mineridae. It contains berberine, palmatine, alkaloids such as coptisine, worenine and columbamaine, and anti-inflammatory and anti-arteriosclerotic effects. The effect is known.

Houttuyniae herba (Scientific name: Houttuynia cordata) is a perennial plant with Saururaceae. It is a perennial herbaceous plant in Korea. It is a perennial herbaceous plant. It is a country like Japan, China, etc. Have been used for a long time as disinfectants, diuretics, antipyretics and so on. In addition, the efficacy of diuretic, detoxification, cardiac, paracetamol, drainage, and anticancer effects is known.

Ginkgo (Ginkgo biloba Linnaeus) is a deciduous arboreous tree belonging to the ginkgo family. It is distributed in the temperate zone except for the high mountains and highlands of China, Korea, and Japan. It is composed of stem, leaf and fruit. These banks are known to have blood circulation promotion and metabolic functions including flavonoid glycoside components.

Madecassoside is a substance isolated from Centella asiatica. Centella asiatica is known to contain asiaticoside, madecassoside, asiatic acid, and madecassic acid, a small herbaceous plant belonging to the wild Umbelliferae family, at a height of 600 to 800 meters above sea level,

An object of the present invention is to provide a method for producing a cosmetic composition for acne improvement which is excellent in the treatment, improvement, prevention and alleviation effect on acne.

Another object of the present invention is to provide a method for producing a cosmetic composition for improving acne which is excellent in antibacterial, skin tone improvement, skin soothing and skin whitening effect.

It is still another object of the present invention to provide a method for producing a cosmetic composition for acne improvement having excellent formulation stability under normal temperature and severe conditions.

It is still another object of the present invention to provide a method for producing a cosmetic composition for acne improvement that is excellent in feeling and has little skin irritation.

It is still another object of the present invention to provide a cosmetic composition for improving acne, which is produced by the method for producing a cosmetic composition for acne improvement.

One aspect of the present invention relates to a method for producing a cosmetic composition for improving acne. In one embodiment, the method for preparing a cosmetic composition for acne improvement comprises the steps of: preparing a first mixture comprising poloxamer, azelaic acid and water at a temperature of 35 ° C to 50 ° C; Adjusting the viscosity of the first mixture to 5,000 cPs to 50,000 cPs at a temperature of 35 ° C to 50 ° C; And a second mixture comprising the first mixture and tea tree leaf oil at a temperature of from 25 캜 to 35 캜, wherein the poloxamer and the zeolite are present in a weight ratio of 1: 1 to 1: 5 .

In one embodiment, the cosmetic composition may contain 3-15% by weight of poloxamer, 5-25% by weight of azelaic acid, 0.1-3% by weight of tea tree leaf oil and 55-85% by weight of water, based on the total weight of the cosmetic composition.

In one embodiment, a viscosity modifier is added to adjust the viscosity of the first mixture, and the viscosity modifier is selected from the group consisting of polyacrylate-13, polyisobutene, polysorbate 20, hydroxyethylcellulose, cellulose gum, , Gellan gum, and agarose.

In another embodiment, the second mixture may further contain 0.01 to 1% by weight of the extract of Rhododendron japonica extract, Rhododendron sulphate extract, Ganoderma lucidum extract, and Madecasone complex in the total weight of the cosmetic composition.

Another aspect of the present invention relates to a cosmetic composition for improving acne, which is produced by the above-described method for producing a cosmetic composition for improving acne. In one embodiment, the cosmetic composition for improving acne includes poloxamer, azelaic acid, tea tree leaf oil and water, wherein the poloxamer and azelaic acid are contained in a weight ratio of 1: 1 to 1: 5.

In one embodiment, the cosmetic composition may comprise 3-15% by weight of poloxamer, 5-25% by weight of azelaic acid, 0.1-3% by weight of tea tree leaf oil and 55-85% by weight of water based on the total weight of the cosmetic composition.

In one embodiment, the cosmetic composition further comprises a viscosity modifier, wherein the viscosity modifier is selected from the group consisting of polyacrylate-13, polyisobutene, polysorbate 20, hydroxyethylcellulose, cellulose gum, xanthan gum, gellan gum, Oats or the like.

In another embodiment, the cosmetic composition further comprises 0.01 to 1% by weight of a mixture of a Rhodiola extract, a Rhododendron syrup extract, a Ganoderma lucidum extract and a Madecasone mixture based on the total weight of the cosmetic composition.

The cosmetic composition for improving acne according to the present invention is excellent in formulation stability at room temperature and in severe conditions even though it contains a high concentration of poorly soluble azelaic acid and is excellent in treatment, improvement, prevention and alleviation effect against acne, It has an excellent skin calming and skin whitening effect, an excellent feeling of use, and less skin irritation.

Fig. 1 (b) is a photograph showing the degree of acne improvement of a subject's forehead area after applying the cosmetic composition according to the present invention to PSI WELL- It is a photograph taken by JANUS of BEING company.
2 (a) is a photograph of a subject's ball area before application of the cosmetic composition according to the present invention, and FIG. 2 (b) is a photograph showing the degree of acne improvement of a subject's ball area after application of the cosmetic composition according to the present invention to PSI It is a photograph taken by JANUS of WELL-BEING company.
3 (a), 5 (b) and 6 (c) are photographs showing the characteristics of Example 1 and Comparative Example 5, respectively.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the invention as claimed.

In the present invention, the poloxamer is defined as a polyoxyethylene-polyoxypropylene triblock copolymer (poly (oxyethylene) -poly (oxypropylene) -poly (oxyethylene) triblock copolymer).

One aspect of the present invention relates to a method for producing a cosmetic composition for improving acne. In one embodiment, the method for preparing a cosmetic composition for improving acne may comprise (a) a first mixture preparation step, (b) a viscosity control step, and (c) a second mixture preparation step. In one embodiment, the method of making a cosmetic composition comprises the steps of: preparing a first mixture comprising poloxamer, azelaic acid and water at a temperature of from 35 캜 to 50 캜; Adjusting the viscosity of the first mixture to 5,000 cPs to 50,000 cPs at a temperature of 35 ° C to 50 ° C; And a second mixture comprising the first mixture and the tea tree oil at a temperature of from 25 캜 to 35 캜.

Hereinafter, the method for producing a cosmetic composition for acne improvement will be described step by step.

(a) the first mixture preparation step

The step is to prepare a first mixture comprising poloxamer, water and azelaic acid. In the present invention, the poloxamer is used for easily mixing poorly soluble azelaic acid with other components. The poloxamer may use at least one of poloxamer 407 and poloxamer 188, but is not limited thereto.

In one embodiment, the poloxamer may be mixed with water in a weight ratio of 1: 2 to 1:10 to form a poloxamer aqueous solution, and then the azelaic acid may be dispersed. When the poloxamer aqueous solution is applied, the azelaic acid can be easily dispersed.

At this time, the poloxamer and azelaic acid may be contained in a weight ratio of 1: 1 to 1: 5. Preferably in a weight ratio of 1: 2 to 1: 5. When the composition is contained at a weight ratio of less than 1: 1, it is ineffective to treat acne, reduce or improve the acne treatment efficiency, and is inefficient. When the weight ratio of the composition is less than 1: 5 It is not easily dispersed in the cosmetic composition, so that the properties of the prepared cosmetic composition may be uneven and the stability of the formulation may be deteriorated.

In embodiments, the first mixture may be prepared at 35 ° C to 50 ° C. Preferably 35 < 0 > C to 45 < 0 > C. The azelaic acid may be easily dispersed at the temperature. When the azelaic acid is prepared at a temperature lower than 35 ° C., the viscosity of the aqueous poloxamer solution may be low. And the viscosity becomes excessively high at a temperature exceeding 50 캜, so that the aqueous solution and azelaic acid are not easily mixed. Even if the aqueous solution is dispersed, the aqueous solution layer and the azelaic acid are separated from each other, .

(b) Viscosity control step

This step is to adjust the viscosity of the first mixture prepared. In one embodiment, the viscosity of the first mixture may be adjusted to 5,000 cPs to 50,000 cPs. And preferably from 10,000 cps to 45,000 cPs. When the viscosity is less than 5,000 cPs, the formulation stability is low, so that the water phase and oil phase components are easily separated from each other, the feeling of use is lowered, If it has a viscosity exceeding 50,000 cPs, it is difficult to mix easily between the components, and the stability of the formulation is lowered, and the feeling of use may be lowered due to strong stickiness.

In one embodiment, the viscosity can be controlled while maintaining the temperature during the preparation of the first mixture. For example, the viscosity of the first mixture can be controlled at 35 ° C to 50 ° C. Preferably from 35 [deg.] C to 45 [deg.] C. The azelaic acid may not be uniformly dispersed with the first mixture at a temperature outside the above-mentioned range, and thus, the properties of the present invention are not uniform and the stability of the formulation is deteriorated .

In one embodiment, the viscosity of the first mixture may be controlled by adjusting the viscosity of the first mixture to improve the stability of the formulation and the feeling of use. The viscosity adjusting agent may be any conventional one. In an embodiment, the viscosity modifier may be at least one selected from polyacrylate-13, polyisobutene, polysorbate 20, hydroxyethyl cellulose, cellulose gum, xanthan gum, gellan gum and agarose, But is not limited thereto.

In embodiments, the viscosity modifier may include polyacrylate-13, polyisobutene, and polysorbate 20.

In an embodiment, the viscosity controlling agent may be included in an amount of 0.1 to 8% by weight based on the total weight of the cosmetic composition of the present invention. And preferably 0.3 to 5% by weight. More preferably from 0.5 to 3% by weight. In the above range, excellent formulation stability and easy viscosity control can be achieved.

(c) the second mixture preparation step

This step is to prepare a second mixture comprising the first viscosity-controlled mixture and tea tree leaf oil.

In one embodiment, the second mixture may be prepared at 25 ° C to 35 ° C. Preferably at 25 ° C to 30 ° C. The azelaic acid may be easily dispersed at the temperature. When the azelaic acid is produced at a temperature lower than 25 ° C, the viscosity of the polycarboxylic acid component is low. However, The viscosity at the time of production becomes excessively high, so that the properties of the present invention are not uniform and the stability of the formulation may deteriorate.

The tea tree leaf oil may be included for the purpose of imparting an excellent scent while enhancing the acne improvement effect of the present invention. The tea tree leaf oil may be contained in an amount of 0.1 to 3% by weight based on the total weight of the cosmetic composition of the present invention. And preferably 0.1 to 2% by weight. More preferably from 0.1 to 1% by weight. In the above range, it is harmless to the human body, has excellent formulation stability, and can be excellent in acne improvement effect and flavor.

In one embodiment, the viscosity of the second mixture may be adjusted to 5,000 cPs to 50,000 cPs. And preferably from 10,000 cps to 45,000 cPs. Within the above range, the properties of the present invention can be uniform and the formulation stability can be excellent.

In another embodiment, the composition of the present invention may further comprise a Huanghui extract, a Houttuynia cordata extract, a ginkgo extract, and a mixture of a madeca saide, in the preparation of the second mixture.

The extracts of Rhodiola, Rhodiola, Bacillus, and Bacillus can be used by extracting raw materials in a dry state or in a natural state, and they can be used by segmenting or grinding to enhance extraction efficiency. In addition, the extracts of Rhodiola, Rhizoctonia sp., And Bacillus can be extracted from various organs or parts, that is, fruits, leaves, flowers, stems, branches and bark. In the case of the above bank, it can be preferably extracted from the fruit.

In the present invention, the Huanghui extract, Huangsheng extract and Ginkgo biloba extract can be prepared using conventional solvents under the conditions of ordinary temperature and pressure. The extraction solvent may be, for example, water, a lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, butyl acetate, ether, chloroform and 1,3-butylene glycol, Is ethyl alcohol, most preferably 80% ethyl alcohol, but is not limited thereto. The extraction solvent may be mixed with about 1 to 20 times by weight of the dried material. As the extraction method, it is possible to use heat extraction, cold extraction, reflux cooling extraction, ultrasonic extraction and the like, and they can be extracted once or repeatedly.

Further, the extraction temperature is not particularly limited as far as the effective activity of the useful component of each material is not removed. For example, it can be extracted by immersion at room temperature, and in heating extraction using a general solvent, it may be 50 to 100 ° C, more preferably 60 to 80 ° C. In the extraction of ultrasonic waves, it is preferable to perform low-temperature extraction at 3 to 50 ° C, more preferably 4 to 20 ° C.

In addition, the extract of the present invention includes not only the extract obtained by the above-mentioned extraction solvent, but also an extract obtained through a conventional purification process. For example, by separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatographies (made for separation by size, charge, hydrophobicity or affinity), and the like, Fractions are also included in the extract of the present invention. The extract of the present invention can be prepared in powder form by an additional process such as vacuum distillation and freeze-drying or spray-drying.

Particularly, in the present invention, the Huangsheng extract, Huangsheng extract and the bank extract are preferably prepared by fermenting each raw material and ultrasonic extraction. The extract prepared through this process exhibits a more enhanced acne improvement effect than the conventional heat extraction method or immersion extraction method.

At this time, the fermentation can be carried out by inoculating Bacillus sp.

In the present invention, the Rhodiola, Rhizobium, and Ginkgo extract may be extracted by a conventional method. For example, (a) wet heat treatment of Rhodophylla, Rhodochrosite, and Bank material at 80 to 100 ° C for 30 to 60 minutes; (b) inoculating a Bacillus sp. microorganism into the heat-treated raw material, and then fermenting at 30 to 60 ° C and pH 5 to 8 for 24 to 48 hours for dry culture; (c) ultrasonically extracting the fermented raw material using an organic solvent; And (d) adding the ingredient to the extract.

In one embodiment, the Rhodiola extract, Rhodophyta extract, Ginkgo extract and Madecasone mixture may be contained in a weight ratio of 0.1 to 2.0: 0.1 to 1.0: 0.1 to 1.0: 0.5 to 5.0 based on the dry powder weight, May be contained in a weight ratio of 1.0: 2.0 to 0.5: 1.0: 0.5 to 1.0: 0.5 to 2.5, and most preferably 2.0: 1.0: 0.5: 2.5. When included in the above range, antibacterial activity, skin regeneration, suppression of sebum secretion, skin sedimentation and whitening function can be significantly enhanced at the same time.

In one embodiment, the Rhodiola extract, Rhododendron extract, Ginkgo extract, and Madecasone may be added in an amount of 0.01 to 3% by weight based on the total weight of the cosmetic composition. Preferably 0.01 to 2% by weight. More preferably from 0.01 to 1% by weight. In the above range, it can be easily mixed with other components of the present invention without stimulating the skin, and excellent in formulation stability, and antibacterial, skin regeneration, suppression of sebum secretion, skin soothing and whitening function can be significantly enhanced at the same time.

In one embodiment of the present invention, the poloxamer may be contained in an amount of 3 to 15% by weight based on the total weight of the cosmetic composition. And preferably 5 to 12% by weight. More preferably 5 to 10% by weight. In the above range, the azelaic acid can be easily dispersed and the formulation stability can be excellent.

The azelaic acid may be included in an amount of 5 to 25% by weight based on the total weight of the cosmetic composition. And preferably 10 to 20% by weight. And more preferably 10 to 17% by weight. In the above range, it is possible to easily mix with the poloxamer, and excellent form stability can be expected, and an excellent acne improvement effect can be expected through antibacterial, skin regeneration, suppression of sebum secretion, and whitening function without skin irritation.

The water may be contained in an amount of 55 to 85% by weight based on the total weight of the cosmetic composition. And preferably 60 to 85% by weight. More preferably 65 to 80% by weight. In the above range, it is possible to easily mix with the poloxamer, and the formulation stability can be excellent.

In addition to the components described above, the cosmetic composition may further contain components contained in a conventional cosmetic composition. For example, the method may further include the components that are listed in the list of cosmetic raw materials and ICID (International Cosmetic Raw house) registered with the KFDA one or more of them. In one embodiment, the cosmetic composition may further comprise a coloring agent, a flavoring agent, a skin moisturizer, a pH adjusting agent, a sequestering agent, a preservative, and the like.

In addition, the cosmetic composition of the present invention can be prepared into any formulation conventionally produced in the art, if possible. For example, they may be formulated as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays, But is not limited thereto. More specifically, the present invention relates to a cosmetic composition comprising: a softening lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, a powder, a fact, a lip gloss, a lipstick, . ≪ / RTI > (O / W), water-in-oil (W / O), water-in- W / O) and water-in-oil-in-water (W / O / W)

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

 When the formulation of the present invention is a solution or an emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 1,3-butylene glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid Amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, or ethoxylated glycerol fatty acid ester.

Another aspect of the present invention relates to a cosmetic composition for improving acne, which is prepared by the method for producing a cosmetic composition for improving acne.

The cosmetic composition of the present invention is excellent in formulation stability even when azelaic acid having a low solubility is contained at a high concentration, has less irritation to the skin, can alleviate acne, improve the skin tone and improve the skin tone.

In one embodiment, the cosmetic composition for improving acne may comprise poloxamer, azelaic acid, tea tree leaf oil, and water.

In one embodiment, the poloxamer and azelaic acid may be present in a weight ratio of 1: 1 to 1: 5. Preferably in a weight ratio of 1: 2 to 1: 5. The azelaic acid can be easily dispersed in the above range, and the acne improvement effect can be excellent. When the composition is contained at a weight ratio of less than 1: 1, it is inefficient because the treatment of acne, When it is contained at a weight ratio exceeding 1: 5, it is not dispersed easily, so that the properties of the prepared cosmetic composition may be uneven and the stability of the formulation may be deteriorated.

In one embodiment, the cosmetic composition may contain 3 to 15% by weight of poloxamer, 5 to 25% by weight of azelaic acid, 0.1 to 3% by weight of tea tree leaf, and 55 to 85% by weight of water, based on the total weight of the cosmetic composition. Preferably 5 to 12% by weight of poloxamer, 10 to 20% by weight of azelaic acid, 0.1 to 2% by weight of tea tree leaf oil and 60 to 85% by weight of water. More preferably 5 to 10% by weight of poloxamer, 10 to 17% by weight of azelaic acid, 0.1 to 1% by weight of tea tree leaf oil and 65 to 80% by weight of water. Within the above range, the properties of the cosmetic composition are uniform and the formulation stability is excellent, and skin tone improvement, whitening, fragrance, acne improvement, and relaxation effect can be excellent.

In another embodiment, the cosmetic composition may further comprise a Rhodiola extract, a Rhododendron extract, a Ginkgo extract, and a mixture of Madecasides. In an embodiment, the Rhodiola extract, Rhodophyta extract, Ginkgo extract and Madecaside mixture may further contain 0.01 to 3% by weight based on the total weight of the cosmetic composition. Preferably 0.01 to 2% by weight. More preferably from 0.01 to 1% by weight. In the above range, it can be easily mixed with other components of the present invention without stimulating the skin, and excellent in formulation stability, and antibacterial, skin regeneration, suppression of sebum secretion, skin soothing and whitening function can be significantly enhanced at the same time.

The mixture of the Rhodiola extract, Rhododendron mori extract, Ganoderma lucidum extract and Madecasone may be contained in a weight ratio of 0.1 to 2.0: 0.1 to 1.0: 0.1 to 1.0: 0.5 to 5.0, more preferably 1.0 to 2.0: 0.5 to 1.0 : 0.5 to 1.0: 0.5 to 2.5, and most preferably 2.0: 1.0: 0.5: 2.5. When included in the above range, antibacterial activity, skin regeneration, suppression of sebum secretion, skin sedimentation and whitening function can be significantly enhanced at the same time.

The acne-improving cosmetic composition may further contain ingredients contained in a conventional cosmetic composition, in addition to the ingredients described above. For example, one or more ingredients listed in the Cosmetic Ingredient List and ICID (International Cosmetic Ingredient Collection) registered in the Food and Drug Administration may be included. Specifically, it may further include at least one of an increasing agent, a moisturizing agent, a pH adjusting agent, an emulsifying agent, a pigment, a flavoring agent, an antiseptic agent or a solvent.

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. However, the following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited to the following examples. The contents not described here are sufficiently technically inferior to those skilled in the art, and a description thereof will be omitted.

Examples and Comparative Examples

Example 1

5% by weight of Poloxamer 407 (product name: PLURACARE® F127 NF PRILL, manufactured by BASF Corporation) was mixed with 20% by weight of distilled water to prepare a poloxamer aqueous solution, and the poloxamer aqueous solution , Powdered azelaic acid, sodium citrate, citric acid, allantoin and distilled water were mixed at about 2,000 rpm using AGI MIXER to prepare a first mixture.

At this time, the viscosity of the first mixture was controlled to be 8,000 cPs at 35 ° C by using a viscosity adjusting agent (polyacrylate-13 , polyisobutene and polysorbate 20) while maintaining the temperature at 35 ° C.

The first mixture was adjusted to a temperature of 25 캜 and had a gel formulation suspended by mixing panthenol, tea tree leaf oil and functional ingredients (Rhodiola extract, Rhodiola extract, Bank extract and Madecasoside), and viscosity of 10,000 cPs ≪ / RTI > was prepared.

At this time, 100 g of each of the dried phthalocyanine, zeolite, and bank was pulverized into 1.0 liter of 80% ethyl alcohol and allowed to stand at room temperature for 5 days, filtered on 300 mesh, left for 1 week, Was filtered with a No. 5 filter paper of Watts. Then, the mixture was concentrated to dryness at 80 ° C using a vacuum decompression concentrator to obtain an extract in powder form, and then the mixture of the above-described extracts of Rhodiola, Rhododendron, and Ganoderma lucidum and Madecasos was mixed at a ratio of 2: 1: 0.5: 2.5.

Examples 2 to 3 and Comparative Examples 1 to 2

Except that the first mixture having the viscosity shown in Table 1 was prepared by mixing the contents of Table 1 below.

Comparative Example 3

The procedure of Example 1 was repeated except that the propylene glycol was used instead of the poloxamer aqueous solution to prepare the first mixture.

Comparative Example 4

Was prepared in the same manner as in Example 1 except that a first mixture having a viscosity of 5,000 cPs was prepared at a temperature of 20 ° C.

Comparative Example 5

Was prepared in the same manner as in Example 1, except that the first mixture having a viscosity of 25,000 cPs was prepared at a temperature of 70 ° C.

Comparative Example 6

The procedure of Example 1 was repeated except that the second mixture was prepared at a temperature of 55 ° C.

Ingredient / content
(weight%) Example Comparative Example One 2 3 One 2 3 4 5 6 Poloxamer aqueous solution Pollock Sommer 5.0 5.0 5.0 5 5 - 5 5 5 Distilled water 20 20 20 20 30 - 20 20 20 Propylene glycol - - - - - 5 - - - Sodium citrate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Citric acid 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Allantoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Distilled water 53.67 48.67 43.67 40.67 39.67 73.67 48.67 48.67 48.67 Azelaixan 15 20 25 28 20 15 20 20 20 Polyacrylate-13,
Polyisobutene,
Polysorbate 20 1.0 1.0 1.0 One - One One One One Panthenol 5.0 5.0 5.0 5 5 5 5 5 5 Tea tree leaf oil 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Functional ingredient 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Sum 100 100 100 100 100 100 100 100 100 The first mixture viscosity (cPs) 8000 10000 12000 17000 10000 3000 5000 25000 35000 The second mixture viscosity (cPs) 10000 15000 20000 23000 8000 3000 5000 53000 55000

Test Example 1. Skin irritation test

The skin patch test was conducted to examine the skin irritation test for each of the cosmetics prepared from the compositions of Examples 1 to 3 and Comparative Examples 1 to 6. The subjects were selected as those who did not have any skin disease at the test site of 20 ~ 40 years old and were performed on 10 persons. The skin of the epidermis, which is a patch area, was wiped with 70% ethanol and dried. Then, 0.1 g of the product was added to the skin for 24 hours, and the skin reaction was checked within 1 hour after removing the patch. The next day (48 hours after the start of the patch) Again. Skin response determinations were made according to the following test criteria. The skin patch test results are shown in Table 2.

* Skin reaction test standard

- no response

± Weak positive reaction (erythema)

+ Positive (erythema)

++ Strong positive reaction (erythema, edema)

+++ Severe positive reaction (erythema, edema, blistering)

Prescription  Number of test persons (persons) Judgment result - ± + ++ +++ Example 1 16 14 2 - - - Example 2 16 15 One - - - Example 3 16 14 2 - - - Comparative Example 1 16 13 One 2 - - Comparative Example 2 16 11 4 One - - Comparative Example 3 16 12 3 One - - Comparative Example 4 16 11 2 2 One - Comparative Example 5 16 10 4 2 - - Comparative Example 6 16 5 8 2 One -

As shown in Table 2, it was found that the skin-irritating cosmetic compositions of Examples 1 to 3 according to the present invention had little skin irritation.

Test Example 2. Evaluation of acne improvement effect

The effects of improving acne were evaluated in the above Examples 1 to 3 and Comparative Examples 1 to 6. The test subjects were divided into 20 groups and nine groups were applied to Examples 1 to 3 and Comparative Examples 1 to 6, respectively. After evening cleansing, they were topically applied to the respective acne portions, and after about 4 weeks, The degree of healing was evaluated. The results are shown in Table 3, Figs. 1 and 2.

Category (persons) very good satisfied usually Slightly dissatisfied dissatisfaction Example 1 10 9 One - - Example 2 11 7 2 - - Example 3 10 8 One - - Comparative Example 1 3 3 6 2 6 Comparative Example 2 3 8 5 3 One Comparative Example 3 - 4 6 8 2 Comparative Example 4 2 7 5 One 5 Comparative Example 5 One 3 2 5 9 Comparative Example 6 5 4 3 One -

FIG. 1 (b) is a graph showing the degree of acne improvement in a subject's forehead area after application of the first embodiment of the present invention to the PSI WELL - This is a picture taken by JANUS of BEING.

FIG. 2 (a) is a photograph of a subject's ball area before applying the second embodiment of the present invention, and FIG. 2 (b) is a graph showing the degree of acne improvement of a subject's ball area after applying the second embodiment of the present invention to PSI WELL - This is a picture taken by JANUS of BEING.

Referring to Table 3, FIG. 1 and FIG. 2, it was found that the cosmetic compositions of Examples 1 to 3 of the present invention had better acne improvement effects than Comparative Examples 1 to 6.

Test Example 4. Evaluation of stability

In order to measure the stability against the degree of separation and discoloration of Examples 1 to 3 and Comparative Examples 1 to 6, a thermostat kept constant at 45 ° C, 25 ° C and 4 ° C, The cosmetics of Comparative Examples 1 to 6 were placed in a sample container and stored for 8 weeks. The degree of discoloration and discoloration were compared and the results are shown in Table 4 below. The degree of separation and discoloration of the product was classified into the following six grades and evaluated.

* Separation and discoloration evaluation criteria

0: No change

1: Very little separation (discoloration)

2: Little separation (discoloration)

3: Severely separated (discoloration)

4: Severely separated (discolored)

5: Severely separated (discolored)

Evaluation items Degree of separation and discoloration Example Comparative Example One 2 3 One 2 3 4 5 6 45 ° C One 0 One 2 2 4 2 One 2 25 ℃ 0 0 0 One One 3 One One 2 4 ℃ 0 0 0 One One 2 One One One daylight 0 0 0 One 0 3 One One One

Referring to Table 4, it was found that the cosmetic compositions of Examples 1 to 3 were less discolored and separated than Comparative Examples 1 to 6. In particular, in Comparative Example 3 in which poloxamer of the present invention was not used Separation and discoloration occurred severely.

Test Example 5. Evaluation of skin improvement effect

When the cosmetic compositions of Examples 1 to 3 and Comparative Examples 1 to 6 were used, overall preferences such as whitening effect, skin soothing effect, and feeling of use were evaluated.

Specifically, the cosmetic compositions of Examples 1 to 3 and Comparative Examples 1 to 6 were used for 45 weeks for 15 to 30 year-old females each for 2 weeks (twice a day (morning and evening)), The 10-point scale (1: very bad → 10: very good) assessed the overall preferences of skin whitening, skin soothing and stickiness and feeling, and then tested for significance with Duncan's multiple range test. As a result, the results shown in Table 5 were obtained.

Evaluation items Example Comparative Example One 2 3 One 2 3 4 5 6 Whitening effect 8.1 ±
0.85 8.5 ±
0.13 8.2 ±
0.63 7.8 ±
0.75 6.9 ±
0.24 6.5 ±
0.25 7.2 ±
0.87 6.3 ±
0.43 7.2 ±
0.25 Skin soothing 8.4 ±
0.57 8.2 ±
0.48 8.5 ±
0.15 7.8 ±
0.21 7.0 ±
0.49 6.4 ±
0.12 6.8 ±
0.64 6.4 ±
0.65 7.4 ±
0.25 Overall preference 8.5 ±
0.44 8.3 ±
0.18 8.6 ±
0.55 6.2 ±
0.68 7.1 ±
0.17 5.1 ±
0.93 6.9 ±
0.38 6.5 ±
0.46 6.9 ±
0.38

Referring to Table 5, it can be seen that Examples 1 to 3, to which the cosmetic composition of the present invention was applied, were superior to Comparative Examples 1 to 6 in whitening effect, skin soothing and overall preference.

Test Example 6. Comparison of Properties by Temperature Control during Manufacturing

In order to compare the properties of the cosmetic composition by temperature control at the time of manufacture, Example 1, Comparative Example 4, Comparative Example 5, and Comparative Example 6 were compared and evaluated in a state after final aging at a temperature of 25 캜 for one day.

3 (a), 3 (b) and 3 (c) show the characteristics of Comparative Example 5, Comparative Example 6, and Example 3, respectively. Referring to FIG. 3, in Example 1, it was found that the azelaic acid phase was mixed in a whitish and stable form. However, in the case of Comparative Example 5 and Comparative Example 6, azelaic acid particles were highlighted, and it was found that the overall property was not smooth.

Also, in the case of Comparative Example 4, which was produced at a temperature lower than that of Examples 1 to 3 of the present invention, the viscosity of the first mixture was too low, so that azelaic acid was not easily dispersed.

Through the test examples, it was confirmed that the cosmetic according to the present invention has excellent formulation stability, less irritation to the skin, excellent skin soothing effect, improved acne, treatment, whitening effect and overall use preference.

Claims (8)

Preparing a first mixture comprising poloxamer, azelaic acid and water at a temperature of 35 DEG C to 50 DEG C;
Adjusting the viscosity of the first mixture to 5,000 cPs to 50,000 cPs at a temperature of 35 ° C to 50 ° C; And
Preparing a second mixture comprising said first mixture and tea tree leaf oil at a temperature of from 25 캜 to 35 캜,
Wherein the poloxamer and azelaic acid are contained in a weight ratio of 1: 1 to 1: 5.
The cosmetic composition according to claim 1, wherein the cosmetic composition comprises 3 to 15% by weight of poloxamer, 5 to 25% by weight of azelaic acid, 0.1 to 3% by weight of tea tree leaf oil and 55 to 85% by weight of water, Gt;
The method according to claim 1, wherein the viscosity of the first mixture is controlled by adding a viscosity modifier,
Wherein the viscosity controlling agent is at least one selected from polyacrylate-13, polyisobutene, polysorbate 20, hydroxyethyl cellulose, cellulose gum, xanthan gum, gellan gum and agarose. Gt;
[2] The method of claim 1, wherein the second mixture comprises 0.01 to 1% by weight of a mixture of Rhodiola extract, Rhododendron sulphate extract, Ganoderma lucidum extract and Madecaoside based on the total weight of the cosmetic composition.
Poloxamer, azelaic acid, tea tree leaf oil and water,
Wherein the poloxamer and azelaic acid are contained in a weight ratio of 1: 1 to 1: 5.
6. The cosmetic composition according to claim 5, wherein the cosmetic composition comprises 3 to 15% by weight of poloxamer, 5 to 25% by weight of azelaic acid, 0.1 to 3% by weight of tea tree leaf oil and 55 to 85% / RTI >
6. The cosmetic composition according to claim 5, wherein the cosmetic composition further comprises a viscosity adjusting agent,
Wherein the viscosity controlling agent is at least one selected from polyacrylate-13, polyisobutene, polysorbate 20, hydroxyethyl cellulose, cellulose gum, xanthan gum, gellan gum and agarose. .
[Claim 5] The cosmetic composition for improving acne according to claim 5, wherein the cosmetic composition further comprises 0.01 to 1% by weight of a mixture of Rhodiola extract, Rhododendron sulphate extract, Ginkgo biloba extract and Madecasone.

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