KR102165559B1 - Cosmetic composition with excellent contribution to improvement - Google Patents
Cosmetic composition with excellent contribution to improvement Download PDFInfo
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- KR102165559B1 KR102165559B1 KR1020190113377A KR20190113377A KR102165559B1 KR 102165559 B1 KR102165559 B1 KR 102165559B1 KR 1020190113377 A KR1020190113377 A KR 1020190113377A KR 20190113377 A KR20190113377 A KR 20190113377A KR 102165559 B1 KR102165559 B1 KR 102165559B1
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- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
본 발명은 여드름 개선 효과가 우수한 화장료 조성물에 관한 것으로, 더욱 상세하게는 항균작용 및 피부 진정작용에 탁월한 효과를 나타내는 어성초 추출물이 함유되어 여드름 개선 효과를 나타내는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition having excellent acne improvement effect, and more particularly, to a cosmetic composition containing Eoseongcho extract showing excellent effect on antibacterial action and skin soothing effect, thereby showing acne improvement effect.
일반적으로 여드름은 피지분비 과잉, 피부각질화 과잉 및 혐기성 피부상재균인 프로피오니박테리움 아크네균의 리파아제(lipase)에 의해 생성된 유리 지방산(free fatty acid)과 각종 저분자 물질들의 자극에 의한 염증 반응이 그 원인으로 알려져 있다. 이러한 여드름을 치료하기 위하여 경구제 또는 외용제 형태의 약제를 사용하였는데, 예를 들면, 피지생성을 억제하는 항안드로겐제, 항염제로 작용하는 비스테로이드 소염제, 레소치놀, 유황, 살리실산, 벤조일퍼옥사이드, 이소트레티노인과 같은 항균제 및 각질박리제, 테트라사이클린, 에리스로마이신, 메크로사이클린 등의 항생물질에 의한 프로피오니박테리움 아크네균의 활성억제 방법 등이 있다. 한편, 최근에는 레티노익산(Retinoic acid) 등의 비타민A 유도체를 이용한 치료 방법과 아젤리아산을 이용한 피부방법도 많이 사용되고 있다.In general, acne is caused by excessive sebum secretion, excessive skin keratinization, and inflammatory reactions caused by stimulation of free fatty acids and various low-molecular substances produced by the lipase of Propionibacterium acne, an anaerobic dermatophyte. It is known as the cause. To treat such acne, oral or external drugs were used, for example, anti-androgens that inhibit sebum production, non-steroidal anti-inflammatory drugs that act as anti-inflammatory agents, resocinol, sulfur, salicylic acid, benzoyl peroxide, Antibacterial agents such as isotretinoin and exfoliating agents, and methods of inhibiting the activity of Propionibacterium acne by antibiotics such as tetracycline, erythromycin, and macrocycline. Meanwhile, in recent years, treatment methods using vitamin A derivatives such as retinoic acid and skin methods using azelaic acid have been widely used.
현재 사용되는 여드름 치료제는 일반적으로 의약품으로 사용되는 것으로 부작용이 있다. 또한 상기에서 설명한 방법들 역시 여드름 치료에 어느 정도 성과를 거두고 있으나, 이의 효과, 부작용 및 사용성 면에서 몇 가지 문제점들을 가지고 있다. 즉, 호르몬제의 사용은 표피의 생장억제나 기타 호르몬 남용 부작용이 보고되어 있으며, 레티노익산과 벤조일퍼옥사이드등의 각질박리제는 각질박리에 따른 피부의 자극성과 접촉성 피부염의 우려가, 테트라사이클린을 위시한 항생물질은 내성균의 출현 및 광과민작용의 가능성이 알려져 있다. 특히, 이소트레티노인은 태아에 최기성 작용이 있음이 알려져 있다. 또한, 몰약 등 종래의 동양 약재 식물 추출물을 이용한 여드름에 유효한 화장료 조성물은 그 효능에 있어서 유효한 효과는 인정되나, 여드름성의 민감성 피부에 대해서는 경우에 따라 알레르기 과민반응을 보이는 경우도 있어 그 사용 범위가 다소 한정될 수 있는 문제점을 가지고 있다.Currently used acne treatments are generally used as pharmaceuticals and have side effects. In addition, the above-described methods have also achieved some results in the treatment of acne, but have some problems in terms of their effectiveness, side effects, and usability. In other words, the use of hormonal agents has been reported to inhibit the growth of the epidermis and other side effects of hormone abuse, and exfoliating agents such as retinoic acid and benzoyl peroxide have concerns about skin irritation and contact dermatitis due to exfoliation. Wish antibiotics are known for the appearance of resistant bacteria and the possibility of photosensitivity. In particular, isotretinoin is known to have a teratogenic effect on the fetus. In addition, cosmetic compositions that are effective against acne using conventional oriental herbal plant extracts such as myrrh are recognized for their effective efficacy, but for acne-related sensitive skin, in some cases, allergic hypersensitivity reactions are observed, so the range of use is somewhat It has a problem that can be limited.
최근에는 식물을 비롯한 천연자원으로부터 상기 부작용들을 줄여 지속적으로 사용할 수 있으며 인체에 무해하면서도 강력한 항여드름균 효과를 갖는 유효성분들을 탐색하여 화장료에 적용하는 연구가 활발히 진행되고 있다.In recent years, researches have been actively conducted to search for active ingredients that can be continuously used by reducing the side effects from natural resources, including plants, and have a strong anti-acne effect while being harmless to the human body and applied to cosmetics.
그러나, 그 효과가 기존의 여드름 치료 물질에 비해 매우 약하거나, 여드름 치료에 관련된 유효물질의 대량 생산이 어려운 문제점이 있다. 특히 천연물은 다양한 성분이 복합적으로 구성되어 있어서 유효 활성물질의 분리, 정제방법이 목적하는 활성물질의 물리화학적 성질에 따라 다르고, 또 여러 가지 서로 다른 원리에 근거한 분리, 정제 방법 중에서도 적절한 방법을 효과적으로 조합하여 사용하여야 하므로 천연물로부터 항여드름균 활성을 지니는 물질을 추출분리하는 데에는 많은 어려움이 있다. 따라서, 인체에 안전하면서도 여드름 피부에 대한 개선효과가 우수한 제품의 개발 필요성이 꾸준히 대두되고 있는 상황이다.However, the effect is very weak compared to the existing acne treatment substances, or there is a problem in that mass production of effective substances related to acne treatment is difficult. In particular, natural products are composed of a variety of ingredients, so the method of separating and purifying the effective active substance differs depending on the physicochemical properties of the desired active substance, and effectively combines the appropriate method among the separation and purification methods based on several different principles. Since it must be used, there are many difficulties in extracting and separating substances with anti-acne activity from natural products. Therefore, the need for the development of a product that is safe for the human body and has an excellent improvement effect on acne skin is steadily emerging.
본 발명의 목적은 항균작용 및 피부 진정작용에 탁월한 효과를 나타내는 어성초 추출물이 함유되어 여드름 개선 효과를 나타내는 화장료 조성물을 제공하는 것이다.It is an object of the present invention to provide a cosmetic composition containing Eoseongcho extract that exhibits excellent antibacterial and soothing effects on the skin, thereby improving acne.
본 발명의 목적은 산화방지제, 킬레이팅제, 향료, 보습제, 어성초 추출물이 함유된 피부컨디셔닝제, 용매, 계면활성제 및 증점제로 이루어지는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물을 제공함에 의해 달성된다.An object of the present invention is achieved by providing a cosmetic composition having excellent acne improvement effect, characterized in that it consists of antioxidants, chelating agents, fragrances, moisturizers, skin conditioning agents containing Eoseongcho extract, solvents, surfactants, and thickeners. .
본 발명의 바람직한 특징에 따르면, 상기 여드름 개선 효과가 우수한 화장료 조성물은 산화방지제 0.001 내지 0.003 중량%, 킬레이팅제 0.02 내지 0.04 중량%, 향료 0.03 내지 0.07 중량%, 보습제 6 내지 6.5 중량%, 어성초 추출물이 함유된 피부 컨디셔닝제 4.5 내지 5.5 중량%, 용매 85 내지 90 중량%, 계면활성제 0.1 내지 0.3 중량% 및 증점제 0.5 내지 1 중량%로 이루어지는 것으로 한다.According to a preferred feature of the present invention, the cosmetic composition having excellent acne improvement effect is from 0.001 to 0.003% by weight of antioxidant, 0.02 to 0.04% by weight of chelating agent, 0.03 to 0.07% by weight of fragrance, 6 to 6.5% by weight of moisturizer, Eoseongcho extract It is to be composed of 4.5 to 5.5% by weight of the skin conditioning agent, 85 to 90% by weight of the solvent, 0.1 to 0.3% by weight of the surfactant, and 0.5 to 1% by weight of the thickener.
본 발명의 더 바람직한 특징에 따르면, 상기 어성초 추출물은 0.005 내지 0.15 중량% 함유되는 것으로 한다.According to a more preferred feature of the present invention, the Eoseongcho extract is to be contained 0.005 to 0.15% by weight.
본 발명의 더욱 바람직한 특징에 따르면, 상기 어성초 추출물이 함유된 피부 컨디셔닝제는 나이아신아미드, 히알루론산나트륨, 글루코노락톤, 인도멀 구슬나무잎추출물, 알에이치-올리고펩타이드-1, 화이트윌로우껍질추출물, 어성초 추출물, 하이드롤라이즈드하이알루로닉애씨드, 알파-알부틴, 인도멀 구술나무꽃 추출물, 아이비고드열매 추출물, 카프릭트리글리세라이드, 병풀 추출물, 가지열매 추출물, 알로에베라꽃 추출물, 홀리바실잎 추출물, 백리향꽃잎 추출물, 브델리아 추출물, 울금 추출물, 참산호말 추출물, 황금뿌리 추출물, 보이차 추출물, 감초뿌리 추출물, 피토스테릴/옥틸도데실라우로일글루타메이트, 마데키소사이드, 카모마일꽃 추출물, 로즈마리잎 추출물, 세라마이드엔피, 대왕송잎 추출물, 느릅나무뿌리 추출물, 달맞이꽃 추출물, 칡뿌리 추출물, 카프릴릴글리콜, 아르기닌, 보스웰리아 추출물 및 아데노신으로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the skin conditioning agent containing the Eoseongcho extract is niacinamide, sodium hyaluronate, gluconolactone, indomal bead leaf extract, RH-oligopeptide-1, white willow bark extract, Eoseongcho Extract, Hydrolyzed Hyaluronic Acid, Alpha-Arbutin, Indomal Oral Tree Flower Extract, Ivy God Fruit Extract, Capric Triglyceride, Centella asiatica extract, Eggplant Extract, Aloe Vera Flower Extract, Holy Basil Leaf Extract, Thyme Petal Extract, Bdelia Extract, Turmeric Extract, True Coral Extract, Golden Root Extract, Puer Tea Extract, Licorice Root Extract, Phytosteril/Octyldodecyluroyl Glutamate, Madechisoside, Chamomile Flower Extract, Rosemary It consists of leaf extract, ceramide NP, giant pine leaf extract, elm root extract, evening primrose extract, arrowroot extract, caprylyl glycol, arginine, boswellia extract, and adenosine.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 증점제는 히드록시에틸셀룰로오스로 이루어지는 것으로 한다.According to a further preferred feature of the present invention, the thickener is made of hydroxyethyl cellulose.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 여드름 개선 효과가 우수한 화장료 조성물에는 상기 여드름 개선 효과가 우수한 화장료 조성물 100 중량부 대비 머루씨 추출물 0.5 내지 1 중량부가 더 함유되는 것으로 한다.According to an even more preferred feature of the present invention, the cosmetic composition having an excellent acne improvement effect is further contained in an amount of 0.5 to 1 part by weight of a maru seed extract relative to 100 parts by weight of the cosmetic composition having an excellent acne improvement effect.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 머루씨 추출물은 머루씨 분쇄물을 유기용매에 침지하고, 75 내지 85℃의 온도에서 100 내지 150분 동안 추출하여 제조되는 것으로 한다.According to an even more preferred feature of the present invention, the merrood seed extract is prepared by immersing the crushed merrood seed in an organic solvent and extracting for 100 to 150 minutes at a temperature of 75 to 85°C.
본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물은 항균작용 및 피부 진정작용에 탁월한 효과를 나타내는 어성초 추출물이 함유되어 여드름을 개선하는 화장료 조성물을 제공하는 탁월한 효과를 나타낸다.The cosmetic composition having excellent acne improvement effect according to the present invention contains Eoseongcho extract, which exhibits excellent effects on antibacterial and skin soothing effects, and shows an excellent effect of providing a cosmetic composition for improving acne.
도 1은 본 발명의 실시예 1을 통해 제조된 여드름 개선 효과가 우수한 화장료 조성물이 적용 여부에 따른 시험참여자 20명의 피부상태를 적용하기 전, 적용 1주후, 적용 2주후로 나눠서 측정하여 나타낸 그래프이다.
도 2 내지 13은 본 발명의 실시예 1을 통해 제조된 여드름 개선 효과가 우수한 화장료 조성물이 적용된 시험참여자 20명의 피부상태를 적용하기 전, 적용 2주후, 적용 4주후로 나눠 피부 상태를 DSLR카메라로 촬영하여 나타낸 사진이다.1 is a graph showing the skin condition of 20 test participants according to whether or not a cosmetic composition having an excellent acne improvement effect prepared in Example 1 of the present invention is applied, measured by dividing it into before, 1 week, and 2 weeks after application. .
2 to 13 show the skin condition of 20 test participants to which the cosmetic composition having excellent acne improvement effect prepared through Example 1 of the present invention was applied, divided into before, 2 weeks, and 4 weeks after application of the skin condition with a DSLR camera. This is a picture taken and shown.
이하에는, 본 발명의 바람직한 실시예와 각 성분의 물성을 상세하게 설명하되, 이는 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 발명을 용이하게 실시할 수 있을 정도로 상세하게 설명하기 위한 것이지, 이로 인해 본 발명의 기술적인 사상 및 범주가 한정되는 것을 의미하지는 않는다.Hereinafter, a preferred embodiment of the present invention and the physical properties of each component will be described in detail, but this is for explaining in detail enough that one of ordinary skill in the art can easily implement the invention, This does not mean that the technical spirit and scope of the present invention are limited.
본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물은 산화방지제, 킬레이팅제, 향료, 보습제, 어성초 추출물이 함유된 피부컨디셔닝제, 용매, 계면활성제 및 증점제로 이루어지며, 산화방지제 0.001 내지 0.003 중량%, 킬레이팅제 0.02 내지 0.04 중량%, 향료 0.03 내지 0.07 중량%, 보습제 6 내지 6.5 중량%, 어성초 추출물이 함유된 피부 컨디셔닝제 4.5 내지 5.5 중량%, 용매 85 내지 90 중량%, 계면활성제 0.1 내지 0.3 중량% 및 증점제 0.5 내지 1 중량%로 이루어지는 것이 바람직하다.The cosmetic composition having an excellent acne improvement effect according to the present invention is composed of an antioxidant, a chelating agent, a fragrance, a moisturizing agent, a skin conditioning agent containing Eoseongcho extract, a solvent, a surfactant, and a thickener, and an antioxidant of 0.001 to 0.003% by weight, 0.02 to 0.04% by weight of chelating agent, 0.03 to 0.07% by weight of fragrance, 6 to 6.5% by weight of moisturizer, 4.5 to 5.5% by weight of skin conditioning agent containing Eoseongcho extract, 85 to 90% by weight of solvent, 0.1 to 0.3% by weight of surfactant % And 0.5 to 1% by weight of the thickener.
상기 산화방지제는 0.001 내지 0.003 중량%가 함유되며, 호장근 뿌리 추출물(Polygonum Cuspidatum Root Extract)로 이루어지는데, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물의 산화를 방지하여 일정한 물성이 유지될 수 있도록 하는 역할을 한다.The antioxidant is contained in an amount of 0.001 to 0.003% by weight, and consists of Polygonum Cuspidatum Root Extract, which prevents oxidation of the cosmetic composition having an excellent acne improvement effect according to the present invention so that certain physical properties can be maintained. Plays a role.
본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물은 수성과 유성성분이 혼합되어 있고, 이들 유성성분 중 일부는 공기, 열, 빛에 의해 쉽게 산화될 수 있으므로 이를 방지하기 위해 산화방지제를 투입하는 것이 바람직하다,The cosmetic composition having excellent acne improvement effect according to the present invention is a mixture of aqueous and oily components, and some of these oily components can be easily oxidized by air, heat, and light, so it is preferable to add an antioxidant to prevent this. Do,
상기의 성분으로 이루어지는 산화방지제의 함량이 0.001 중량% 미만이면 상기의 효과가 미미하며, 산화방지제의 함량이 0.003 중량%를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 피부자극이 높아지고 제조비용을 증가시키게 된다.If the content of the antioxidant consisting of the above components is less than 0.001% by weight, the above effect is insignificant, and if the content of the antioxidant exceeds 0.003% by weight, the above effect is not greatly improved, but skin irritation increases and manufacturing cost is reduced. Will increase.
상기 킬레이팅제는 0.02 내지 0.04 중량%가 함유되며, 다이소듐이디티에이로 이루어지는데, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물에 함유된 유효성분의 피부침투 효과를 향상시키는 역할을 한다. 상기의 성분으로 이루어지는 킬레이팅제는 피부의 구조를 변화시키고 유효성분을 피부 깊숙히 침투시키며 혈류에 다른화학물질의 합류량을 증대시켜주는 역할을 하기 때문에, 본 발명에 따른 화장료 조성물의 여드름개선 효과를 더욱 향상시키는 역할을 한다.The chelating agent is contained in an amount of 0.02 to 0.04% by weight, and is made of disodium EDTA, and serves to improve the skin penetration effect of the active ingredient contained in the cosmetic composition having excellent acne improvement effect according to the present invention. Since the chelating agent composed of the above components changes the structure of the skin, penetrates the active ingredient deeply into the skin, and serves to increase the confluence of other chemicals in the bloodstream, the cosmetic composition according to the present invention has the effect of improving acne. It serves to further improve.
상기 킬레이팅제의 함량의 0.02 중량% 미만이면 상기의 효과가 미미하며, 상기 킬레이팅제의 함량이 0.04 중량%를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 피부 자극을 증가시키기 때문에 바람직하지 못하다.If the content of the chelating agent is less than 0.02% by weight, the above effect is insignificant, and if the content of the chelating agent exceeds 0.04% by weight, the above effect is not significantly improved, and skin irritation is increased. Can not do it.
상기 향료는 0.03 내지 0.07 중량%가 함유되며, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물에 다양한 향을 부여하는 역할을 하는데, 향료의 성분은 특별히 한정되지 않고 화장료에 사용할 수 있는 것이면 어떠한 것이든 사용가능하다.The fragrance contains 0.03 to 0.07% by weight, and serves to impart various fragrances to the cosmetic composition having an excellent acne improvement effect according to the present invention. The component of the fragrance is not particularly limited, and any component that can be used in cosmetics Can be used.
상기 보습제는 6 내지 6.5 중량%가 함유되며, 부틸렌글리콜과 글리세린으로 이루어지는데, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물에 보습효과를 부여하는 역할을 한다.The moisturizing agent is contained in 6 to 6.5% by weight, and consists of butylene glycol and glycerin, and serves to impart a moisturizing effect to the cosmetic composition having excellent acne improvement effect according to the present invention.
상기의 성분으로 이루어지는 보습제의 함량이 6 중량% 미만이면 상기와 같은 보습효과가 미미하며, 상기 보습제의 함량이 6.5 중량%를 초과하게 되면 보습효과는 크게 향상되지 않으면서 상대적으로 다른 기능성 성분의 함량이 줄어들기 때문에 바람지하지 못하다.If the content of the moisturizing agent consisting of the above components is less than 6% by weight, the moisturizing effect as described above is insignificant, and when the content of the moisturizing agent exceeds 6.5% by weight, the moisturizing effect is not significantly improved, and the content of other functional ingredients It is not cheating because it decreases.
상기 어성초 추출물이 함유된 피부 컨디셔닝제는 4.5 내지 5.5 중량%가 함유되며, 나이아신아미드, 히알루론산나트륨, 글루코노락톤, 인도멀 구슬나무잎추출물, 알에이치-올리고펩타이드-1, 화이트윌로우껍질추출물, 어성초 추출물, 하이드롤라이즈드하이알루로닉애씨드, 알파-알부틴, 인도멀 구술나무꽃 추출물, 아이비고드열매 추출물, 카프릭트리글리세라이드, 병풀 추출물, 가지열매 추출물, 알로에베라꽃 추출물, 홀리바실잎 추출물, 백리향꽃잎 추출물, 브델리아 추출물, 울금 추출물, 참산호말 추출물, 황금뿌리 추출물, 보이차 추출물, 감초뿌리 추출물, 피토스테릴/옥틸도데실라우로일글루타메이트, 마데키소사이드, 카모마일꽃 추출물, 로즈마리잎 추출물, 세라마이드엔피, 대왕송잎 추출물, 느릅나무뿌리 추출물, 달맞이꽃 추출물, 칡뿌리 추출물, 카프릴릴글리콜, 아르기닌, 보스웰리아 추출물 및 아데노신으로 이루어지는 것이 바람직하다.The skin conditioning agent containing the Eoseongcho extract is contained in 4.5 to 5.5% by weight, niacinamide, sodium hyaluronate, gluconolactone, indomal bead leaf extract, RH-oligo peptide-1, white willow bark extract, Eoseongcho Extract, Hydrolyzed Hyaluronic Acid, Alpha-Arbutin, Indomal Oral Tree Flower Extract, Ivy God Fruit Extract, Capric Triglyceride, Centella asiatica extract, Eggplant Extract, Aloe Vera Flower Extract, Holy Basil Leaf Extract, Thyme Petal Extract, Bdelia Extract, Turmeric Extract, True Coral Extract, Golden Root Extract, Puer Tea Extract, Licorice Root Extract, Phytosteril/Octyldodecyluroyl Glutamate, Madechisoside, Chamomile Flower Extract, Rosemary It is preferable to consist of leaf extract, ceramide NP, giant pine leaf extract, elm root extract, evening primrose extract, arrowroot extract, caprylyl glycol, arginine, boswellia extract, and adenosine.
상기 어성초(Houttuynia cordata Thunberg)는 양모밀의 개화기의 지상부를 의미하는 것으로서, 잎에서 고기 비린내가 나기 때문에 붙여진 이름이다. 옛 중국의 진(秦)나라에서는 저자(菹子), 즉 젓갈과 같은 냄새가 나는 식물이라고 불렀는데 저(菹)는 즙과 음이 비슷하여 즙채라고 부르게 되었다.The Houttuynia cordata Thunberg refers to the above-ground part of the flowering period of wool wheat, and is named because the leaves have a fishy smell of meat. In ancient China's Qin Dynasty, it was called the author (菹子), that is, a plant that smells like salted fish.
어성초는 해열, 배농작용이 뛰어나 폐농양으로 인한 기침, 피고름을 토할 때, 폐렴, 급만성 기관지염, 장염, 요로감염증 및 종기에 사용되며, 열이 많고 소변을 못 볼 때에도 사용한다. 어성초의 약리작용으로 항균작용, 면역증강작용, 항염증작용, 이뇨작용 및 진해작용이 보고되었다. 또한, 어성초는 피를 맑게 하고 이소쿠에르치트린과 쿠에르치트린 플러스 알파의 물질이 상승해서 모세혈관의 혈액 순환 작용을 촉진한다.Eoseongcho has excellent antipyretic and draining effects, so it is used for coughing from lung abscess, vomiting blood pus, pneumonia, acute and chronic bronchitis, enteritis, urinary tract infections, and boils. As the pharmacological action of Eoseongcho, antibacterial, immune enhancing, anti-inflammatory, diuretic, and antitussive effects have been reported. In addition, Eoseongcho clears the blood and promotes the blood circulation of capillaries by increasing the substances of isoquercitrin and quercitrin plus alpha.
아울러, 어성초는 전통약용 식물로서 수종, 매독, 방광염, 자궁염, 폐염 및 중풍 등 광범위한 치료효과가 있는 것으로 보고되고 있으며, 현재까지 어성초에 관한 연구로는 어성초 뿌리의 항균활성, 항종양, 항백혈병 및 고지혈 억제효과 등이 보고되었으며, 생리활성물질인 quercitrin은 다양한 생리활성 기능이 있는 것으로 보고되었다.In addition, Eoseongcho is a traditional medicinal plant and has been reported to have a wide range of therapeutic effects such as species, syphilis, cystitis, uterine inflammation, pneumonia, and stroke. Antihyperlipidemic effects have been reported, and quercitrin, a physiologically active substance, has been reported to have various physiologically active functions.
또한, 상기 어성초 추출물은 통상적인 열수 추출법을 이용하여 제조되며, 상기 어성초 추출물 외에도 상기 어성초 추출물이 함유된 피부컨디셔닝제에 함유되는 각종 추출물을 모두 통상적인 열수추출법을 사용하여 제조될 수 있다.In addition, the Eoseongcho extract is prepared using a conventional hot water extraction method, in addition to the Eoseongcho extract, various extracts contained in the skin conditioning agent containing the Eoseongcho extract can be prepared using a conventional hot water extraction method.
상기 어성초 추출물은 항균작용 외에도 피부 진정작용에 탁월한 효과를 나타내기 때문에, 여드름을 개선하는 효과를 나타내는데, 이때, 어성초 추출물은 0.005 내지 0.15 중량% 함유되는 것이 더욱 바람직하다.Since the Eoseongcho extract exhibits an excellent effect on skin soothing effects in addition to the antibacterial action, it exhibits an effect of improving acne. In this case, the Eoseongcho extract is more preferably contained in an amount of 0.005 to 0.15% by weight.
상기 어성초 추출물의 함량이 0.005 중량% 미만이면 상기의 효과가 미미하며, 상기 어성초 추출물의 함량이 0.15 중량%를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 제조비용을 증가시키고 본 발명에 따른 화장료 조성물의 보존성 및 안정성을 저하시키게 된다.If the content of the Eoseongcho extract is less than 0.005% by weight, the above effect is insignificant, and if the content of the Eoseongcho extract exceeds 0.15% by weight, the above effect is not significantly improved, and the manufacturing cost is increased and the cosmetic according to the present invention The preservation and stability of the composition are deteriorated.
상기 용매는 85 내지 90 중량%가 함유되며, 정제수, 디프로필렌글리콜, 펜틸렌글라이콜 및 1,2-헥산디올로 이루어지는데, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물을 구성하는 성분들이 고르게 혼합될 수 있도록 하는 역할을 한다.The solvent contains 85 to 90% by weight, and consists of purified water, dipropylene glycol, pentylene glycol, and 1,2-hexanediol. The components constituting the cosmetic composition having excellent acne improvement effect according to the present invention are evenly selected. It plays a role in allowing it to be mixed.
상기 계면활성제는 0.1 내지 0.3 중량%가 함유되며, 하이드로제네이티드레시틴 및 C12-13 파레스-9으로 이루어지는데, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물을 구성하는 성분 중 유상과 수상의 성분 들이 고르게 혼합될 수 있도록 하는 역할을 한다.The surfactant contains 0.1 to 0.3% by weight, and consists of hydrogenated lecithin and C12-13 pares-9. Among the components constituting the cosmetic composition having excellent acne improvement effect according to the present invention, the components of the oil phase and the water phase are It plays a role in helping to mix evenly.
상기 증점제는 0.5 내지 1 중량%가 함유되며, 히드록시에틸셀룰로오스로 이루어지는데, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물의 점도를 향상시켜 피부 도포시에 밀착성능을 향상시키는 역할을 한다.The thickener is contained in an amount of 0.5 to 1% by weight, and is made of hydroxyethyl cellulose, and serves to improve the adhesion performance during skin application by improving the viscosity of the cosmetic composition having an excellent acne improvement effect according to the present invention.
상기 증점제의 함량이 0.5 중량% 미만이면 상기의 효과가 미미하며, 상기 증점제의 함량이 1.0 중량%를 초과하게 되면 본 발명에 따른 화장료 조성물의 점도가 지나치게 증가하여 끈적이는 느낌이 증가하기 때문에 바람지하지 못하다.If the content of the thickener is less than 0.5% by weight, the above effect is insignificant, and if the content of the thickener exceeds 1.0% by weight, the viscosity of the cosmetic composition according to the present invention increases too much to increase the stickiness. Can not do it.
또한, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물에는 상기 여드름 개선 효과가 우수한 화장료 조성물 100 중량부 대비 머루씨 추출물 0.5 내지 1 중량부가 더 함유될 수도 있는데, 머루씨 추출물이 함유되면 여드름 개선 효과가 우수한 화장료 조성물에 여드름 개선효과가 더욱 향상된다.In addition, the cosmetic composition having an excellent acne improvement effect according to the present invention may further contain 0.5 to 1 parts by weight of a marooseed extract relative to 100 parts by weight of the cosmetic composition having an excellent acne improvement effect. Acne improvement effect is further improved in excellent cosmetic composition.
머루(Wild grape/Vitis cognetiea)는 갈매나무목(Rhamnales) 포도과(Vitaceae)에 속하는 낙엽성 덩굴식물로 포도와 형상이 비슷하나 산에서 야생으로 자생하며, 내한성과 병충해 저항성이 강한 성질을 지녔다. 한국, 중국, 일본 등의 동북아시아에 주로 많이 분포하고 있으며, 시중에서 판매되고 있는 머루는 대부분 개량머루(Vitis spp) 품종으로 추정되고 있다. 개량머루는 야생머루인 새머루(V flexuosa Thunb)를 모본으로 하고 포도의 일종인 콩코드를 부본으로 하여 교배 육종한 것으로 알려지고 있는데, 상기 머루의 씨는 항산화 작용이 우수하다고 알려져 있지만, 머루씨 추출물은 항산화 작용 외에도 우수한 항균작용을 나타내어 여드름에 매우 효과적이다.Wild grape/Vitis cognetiea is a deciduous vine plant belonging to the Rhamnales Vitaceae family.It is similar in shape to grapes, but grows wild in the mountains, and has strong resistance to cold and pests. It is mainly distributed in Northeast Asia, such as Korea, China, and Japan, and most of the apricots sold on the market are estimated to be Vitis spp varieties. It is known that the modified beetroot is cross-breed using the wild beetroot (V flexuosa Thunb) as a model and the concord, a kind of grape, as a subsidiary, and the seeds of the beetroot are known to have excellent antioxidant activity, but beetroot seed extract In addition to its antioxidant activity, silver exhibits excellent antibacterial activity and is very effective against acne.
상기 머루씨 추출물은 머루씨 분쇄물 100 중량부를 유기용매 500 내지 1500 중량부에 침지하고, 75 내지 85℃의 온도에서 100 내지 150분 동안 추출하여 제조되는데, 상기 유기용매는 에틸알코올로 이루어지는 것이 가장 바람직하며, 상기 유기용매를 대신해 물을 사용하는 열수 추출법을 이용하여 제조될 수도 있다.The marouse seed extract is prepared by immersing 100 parts by weight of the crushed merrood seed in 500 to 1500 parts by weight of an organic solvent and extracting for 100 to 150 minutes at a temperature of 75 to 85°C, and the organic solvent is most composed of ethyl alcohol. Preferably, it may be prepared by using a hot water extraction method using water instead of the organic solvent.
상기 머루씨 추출물의 함량이 0.5 중량부 미만이면 여드름 개선효과의 향상이 미미하며, 상기 머루씨 추출물의 함량이 1.0 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 화장료 조성물의 보존성 및 안정성을 저하시킬 수 있다.If the content of the maroo seed extract is less than 0.5 parts by weight, the improvement of the acne improvement effect is insignificant, and when the content of the maroo seed extract exceeds 1.0 part by weight, the above effect is not significantly improved, and the preservation and stability of the cosmetic composition is improved. Can lower it.
또한, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물은 베이스 성분과 혼합되어 앰플, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 오일, 왁스, 파우더, 스프레이, 비누, 클린징, 팩, 파운데이션 및 모발 화장료로 이루어진 그룹에서 선택된 하나의 제형으로 제조될 수 있다.In addition, the cosmetic composition having excellent acne improvement effect according to the present invention is mixed with a base component to provide ampoules, suspensions, emulsions, pastes, gels, creams, lotions, oils, waxes, powders, sprays, soaps, cleansing, packs, foundations and It can be prepared in one formulation selected from the group consisting of hair cosmetics.
이하에서는, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물의 제조방법 및 그 제조방법을 통해 제조된 화장료 조성물의 물성을 실시예를 들어 설명하기로 한다.Hereinafter, a method for producing a cosmetic composition having excellent acne improvement effect according to the present invention and physical properties of the cosmetic composition prepared through the method will be described with reference to examples.
<실시예 1><Example 1>
하기 표 1에 나타낸 성분을 혼합하고, 150rpm의 속도로 10분 동안 교반하여 여드름 개선 효과가 우수한 화장료 조성물을 제조하였다.The ingredients shown in Table 1 were mixed and stirred at a speed of 150 rpm for 10 minutes to prepare a cosmetic composition having excellent acne improvement effect.
<표 1><Table 1>
상기 실시예 1을 통해 제조된 피부미백 및 잡티 개선용 화장료 조성물의 겉 기미 및 잡티 개선 효과를 측정하였다.The effect of improving skin blemishes and blemishes of the cosmetic composition for skin whitening and blemishes prepared in Example 1 was measured.
단, 시험은 만 19~59세의 성인 여성 21명의 시험대상자가 참여하였고, 중도 탈락 1명을 제외한 총 20명의 시험대상자가 시험을 완료하였다.However, 21 female subjects aged 19 to 59 participated in the test, and a total of 20 subjects excluding 1 drop out of the test completed the test.
상기 실시예 1을 통해 제조된 피부미백 및 잡티 개선용 화장료 조성물을 얼굴전체에 적당량 덜어 골고루 펴서 1일 2회에 걸쳐 바른 후 흡수시키는 과정으로 진행하였다.The cosmetic composition for skin whitening and blemishes prepared in Example 1 was taken over the entire face, spread evenly, applied twice a day, and then absorbed.
1)피부 측정 방법 및 절차1) Skin measurement method and procedure
기기적 피부 측정을 위해 시험대상자는 준비된 세정제로 먼저 전박 부위를 세정한 후 항온항습조건(온도 20~24℃, 습도 40~60%)의 공간에서 약 30분간 피부 안정을 취해 측정 환경에 적응하도록 하였다. 시험제품 적용 부위 피부 측정 및 사진 촬영을 하였고 매번 같은 조건에서 동일한 연구자에 의해 진행되었다.For mechanical skin measurement, the test subject first cleans the whole thin part with a prepared detergent, and then stabilizes the skin for about 30 minutes in a space under constant temperature and humidity conditions (temperature 20~24℃, humidity 40~60%) to adapt to the measurement environment. I did. The skin of the test product application area was measured and photographed, and each time it was conducted by the same researcher under the same conditions.
2)외부 자극에 의한 손상 피부 개선 측정2) Measurement of improvement of damaged skin by external stimulation
외부 자극에 의한 손상 피부 개선 측정은 시험대상자의 전박 부위에 제품 미사용 부위와 제품 사용 부위를 구획한 뒤, 1% SLS(Sodium Lauryl Sulfate) 용액을 IQ Chamber에 적하하여 각 부위에 24시간 동안 첩포하였다. 인위적으로 피부를 손상시킨 뒤 첩포를 제거하고 정해진 부위에만 시험제품을 2주간 사용하도록 한 후, Vapometer를 사용하여 SLS 첩포 전과 제품 사용 전(SLS 24시간 첩포 및 제거 후), 제품 사용 1일 후, 제품 사용 7일 후 및 제품 사용 14일 후 각 부위의 피부 경표피수분손실량을 측정하였다. 피부 경표피수분손실량 측정은 부위당 1회 측정하였고, 그 단위는 g/m2h이다. 경표피수분손실량 측정값은 외부 자극에 의한 손상 피부 개선 정도와 반비례하므로 측정값이 낮아질수록 외부 자극에 의해 손상된 피부가 개선됨을 의미한다.In order to measure the improvement of damaged skin due to external irritation, after partitioning the unused area and the area where the product was used on the whole skin of the subject, 1% SLS (Sodium Lauryl Sulfate) solution was dropped into the IQ Chamber and applied to each area for 24 hours. . After artificially damaging the skin, remove the patch and use the test product for 2 weeks only on the designated area.After using the Vapometer, before the SLS patch, before using the product (after applying and removing SLS 24 hours), 1 day after using the product, The amount of transepidermal moisture loss in each area was measured 7 days after product use and 14 days after product use. The transepidermal moisture loss was measured once per site, and the unit was g/m 2 h. Since the measured value of transepidermal moisture loss is inversely proportional to the degree of improvement of damaged skin due to external stimuli, the lower the measured value, the better the damaged skin due to external stimuli.
3)통계적 결과 분석 방법3) Statistical result analysis method
시험제품 사용 부위와 미사용 부위 간의 피부 측정 변화 값의 유의성 여부를 판단하기 위하여 통계 분석 프로그램인 SPSS 23.0을 사용하여 검증하였다. 유의확률은 95% 신뢰구간에서 p<0.05 일 때 통계적 유의성을 확인하였다.The statistical analysis program SPSS 23.0 was used to verify the significance of the skin measurement change values between the used and unused areas of the test product. The statistical significance was confirmed when the significance probability was p<0.05 in the 95% confidence interval.
*시험제품 사용 부위와 미사용 부위 간 비교*Comparison between the test product used and unused parts
- 정규성 검정 만족: Independent T-test (모수적 방법)-Satisfaction with normality test: Independent T-test (parametric method)
- 정규성 검정 불만족: Mann-Whitney U test (비모수적 방법).-Unsatisfied with normality test: Mann-Whitney U test (nonparametric method).
본 시험에 참여한 시험대상자 20명에 대한 정보를 아래 표 2에 나타내었다.Table 2 below shows information on 20 subjects who participated in this test.
<표 2><Table 2>
본 시험에 참여한 시험대상자 20명의 피부 측정 결과를 아래 표 3 내지 4 및 도 1 내지 13에 나타내었다.The skin measurement results of 20 subjects participating in this test are shown in Tables 3 to 4 and FIGS. 1 to 13 below.
<표 3><Table 3>
<표 4><Table 4>
상기 표 3 내지 4 및 아래 도 1 내지 13에 나타낸 것처럼, 본 발명의 실시예 1을 통해 제조된 여드름 개선 효과가 우수한 화장료 조성물은 제품 사용 전에 비해 제품 사용 후 외부 자극에 의한 손상 피부 개선 결과, 사용 4주 후 통계적으로 손상 피부가 유의하게 감소하였다(p<0.05).As shown in Tables 3 to 4 and FIGS. 1 to 13 below, the cosmetic composition having excellent acne improvement effect prepared through Example 1 of the present invention is used as a result of improving damaged skin due to external irritation after using the product compared to before using the product. After 4 weeks, there was a statistically significant decrease in damaged skin (p<0.05).
따라서, 본 발명에 따른 여드름 개선 효과가 우수한 화장료 조성물은 항균작용 및 피부 진정작용에 탁월한 효과를 나타내는 어성초 추출물이 함유되어 여드름 개선 효과를 나타낸다.Therefore, the cosmetic composition having excellent acne improvement effect according to the present invention contains Eoseongcho extract, which exhibits excellent effects on antibacterial action and skin soothing action, and exhibits acne improvement effect.
Claims (7)
상기 어성초 추출물이 함유된 피부 컨디셔닝제는 나이아신아미드, 히알루론산나트륨, 글루코노락톤, 인도멀 구슬나무잎추출물, 알에이치-올리고펩타이드-1, 화이트윌로우껍질추출물, 어성초 추출물, 하이드롤라이즈드하이알루로닉애씨드, 알파-알부틴, 인도멀 구술나무꽃 추출물, 아이비고드열매 추출물, 카프릭트리글리세라이드, 병풀 추출물, 가지열매 추출물, 알로에베라꽃 추출물, 홀리바실잎 추출물, 백리향꽃잎 추출물, 브델리아 추출물, 울금 추출물, 참산호말 추출물, 황금뿌리 추출물, 보이차 추출물, 감초뿌리 추출물, 피토스테릴/옥틸도데실라우로일글루타메이트, 마데키소사이드, 카모마일꽃 추출물, 로즈마리잎 추출물, 세라마이드엔피, 대왕송잎 추출물, 느릅나무뿌리 추출물, 달맞이꽃 추출물, 칡뿌리 추출물, 카프릴릴글리콜, 아르기닌, 보스웰리아 추출물 및 아데노신으로 이루어지는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물.
It consists of antioxidants, chelating agents, fragrances, moisturizers, skin conditioning agents containing Eoseongcho extract, solvents, surfactants and thickeners,
Skin conditioning agents containing the Eoseongcho extract, niacinamide, sodium hyaluronate, gluconolactone, Indomal bead leaf extract, RH-oligo peptide-1, white willow bark extract, Eoseongcho extract, hydrolyzed hyaluronic acid Ronic Acid, Alpha-Arbutin, Indomal Oral Tree Flower Extract, Ivy God Fruit Extract, Capric Triglyceride, Centella asiatica Extract, Eggplant Fruit Extract, Aloe Vera Flower Extract, Holly Basil Leaf Extract, Thyme Petal Extract, Brelia Extract , Turmeric extract, true coral extract, golden root extract, puer tea extract, licorice root extract, phytosteryl/octyldodecyluroyl glutamate, madechisoside, chamomile flower extract, rosemary leaf extract, ceramide NP, giant pine leaf extract , Elm root extract, evening primrose extract, arrowroot extract, caprylyl glycol, arginine, boswellia extract, and a cosmetic composition having excellent acne improvement effect, characterized in that consisting of adenosine.
상기 여드름 개선 효과가 우수한 화장료 조성물은 산화방지제 0.001 내지 0.003 중량%, 킬레이팅제 0.02 내지 0.04 중량%, 향료 0.03 내지 0.07 중량%, 보습제 6 내지 6.5 중량%, 어성초 추출물이 함유된 피부 컨디셔닝제 4.5 내지 5.5 중량%, 용매 85 내지 90 중량%, 계면활성제 0.1 내지 0.3 중량% 및 증점제 0.5 내지 1 중량%로 이루어지는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물.
The method according to claim 1,
The cosmetic composition having an excellent acne improvement effect is from 0.001 to 0.003% by weight of an antioxidant, from 0.02 to 0.04% by weight of a chelating agent, from 0.03 to 0.07% by weight of a fragrance, from 6 to 6.5% by weight of a moisturizer, 4.5 to 4.5 to a skin conditioning agent containing Eoseongcho extract. A cosmetic composition having excellent acne improvement effect, characterized in that consisting of 5.5% by weight, 85 to 90% by weight of a solvent, 0.1 to 0.3% by weight of a surfactant, and 0.5 to 1% by weight of a thickener.
상기 어성초 추출물은 0.005 내지 0.15 중량% 함유되는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물.
The method according to claim 1 or 2,
The Eoseongcho extract is a cosmetic composition having excellent acne improvement effect, characterized in that it contains 0.005 to 0.15% by weight.
상기 증점제는 히드록시에틸셀룰로오스로 이루어지는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물.
The method according to claim 1 or 2,
The cosmetic composition having excellent acne improvement effect, characterized in that the thickener is made of hydroxyethyl cellulose.
상기 여드름 개선 효과가 우수한 화장료 조성물에는 상기 여드름 개선 효과가 우수한 화장료 조성물 100 중량부 대비 머루씨 추출물 0.5 내지 1 중량부가 더 함유되는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물.
The method according to claim 1 or 2,
The cosmetic composition having excellent acne-improving effect contains 0.5 to 1 part by weight of a maru seed extract relative to 100 parts by weight of the cosmetic composition having excellent acne-improving effect.
상기 머루씨 추출물은 머루씨 분쇄물을 유기용매에 침지하고, 75 내지 85℃의 온도에서 100 내지 150분 동안 추출하여 제조되는 것을 특징으로 하는 여드름 개선 효과가 우수한 화장료 조성물.The method of claim 6,
The Meroo Seed Extract is a cosmetic composition having excellent acne improvement effect, characterized in that prepared by immersing the crushed Meroo Seed in an organic solvent and extracting for 100 to 150 minutes at a temperature of 75 to 85°C.
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| KR1020190113377A Active KR102165559B1 (en) | 2019-07-22 | 2019-09-16 | Cosmetic composition with excellent contribution to improvement |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112618461A (en) * | 2021-01-14 | 2021-04-09 | 杭州妍创化妆品有限公司 | Preparation method of plant and polypeptide compound acne-removing and bacteriostatic essence |
| KR102253095B1 (en) * | 2020-11-06 | 2021-05-17 | 주식회사 허브테라피 | Cosmetic composition for improving acned skin, Manufacturing method thereof and functional cosmetics for improving acned skin containing the same |
| KR20230120358A (en) * | 2022-02-09 | 2023-08-17 | 동명대학교산학협력단 | Cosmetic composition containing ingredients with high stability |
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| KR100870110B1 (en) * | 2007-06-11 | 2008-11-25 | 방선이 | Cosmetic composition for acne skin containing melon seed extract |
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| KR102253095B1 (en) * | 2020-11-06 | 2021-05-17 | 주식회사 허브테라피 | Cosmetic composition for improving acned skin, Manufacturing method thereof and functional cosmetics for improving acned skin containing the same |
| CN112618461A (en) * | 2021-01-14 | 2021-04-09 | 杭州妍创化妆品有限公司 | Preparation method of plant and polypeptide compound acne-removing and bacteriostatic essence |
| KR20230120358A (en) * | 2022-02-09 | 2023-08-17 | 동명대학교산학협력단 | Cosmetic composition containing ingredients with high stability |
| KR102669988B1 (en) * | 2022-02-09 | 2024-05-29 | 동명대학교 산학협력단 | Cosmetic composition containing ingredients with high stability |
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