CN102366397B - Skin-whitening chloasma-reducing skin-brightening composition, skin care product therewith, and preparation method thereof - Google Patents
Skin-whitening chloasma-reducing skin-brightening composition, skin care product therewith, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a skin-whitening chloasma-reducing skin-brightening composition comprising raw materials of, by weight: 0.5 to 20 parts of nicotinamide, 0.1 to 15 parts of L-ascorbic acid 2-glucoside, 0.1 to 10 parts of an yeast extract, 0.05 to 10 parts of sodium lactate/sodium gluconate, 0.01 to 3.5 parts of sodium hydroxide, and 10 to 60 parts of water. With the composition provided by the invention, appearing and transferring of skin melanin can be inhibited or prevented from various perspectives; skin collagen protein synthesizing can be promoted, skin nutrients can be supplemented, such that skin aging can be retarded; and whitening effects can be achieved rapidly. Whitening active components are likely to be decomposed, oxidized, and discolored. With the composition, the problems can be solved; influences of lights and heat on the effective components are reduced. The product produced by the invention is safer than other whitening agents. With the product produced by the invention, nutrients required by skins can be provided. With a sustained-releasing technology, the whitening effect is more durable.
Description
Technical field
The present invention relates to cosmetic field, especially relate to a kind of Whitening, spot cosmetic composition, the skin care item that contain said composition and preparation method
Background technology
Melanin is a kind of protein that is present in everyone skin basal layer; ultraviolet irradiation can make melanin change; generate a kind of material of protecting skin; then melanin mobile layer by layer via cellular metabolism again; arrive the skin epidermal area, formed the skin problems such as our present skin darkening of seeing and the colour of skin be irregular.
Because melanic generation mainly is the oxidative chain process that is subjected to tyrosinase activity control, so whitening agent achieves the goal by three kinds of approach usually:
1, be to prevent that by restraint of tyrosinase activity or blocking oxide chain melanin from generating greatly.
2, a part of whitening product can reach by the vat black pigment effect of Whitening, spot.
3, a part of whitening product can by suppressing established melanin transfer to epidermis cell, promote that containing melanic horn cell comes off to reach the skin whitening effect.
At present, the Effect raw material that skin-lightening cosmetic adds on the market mainly comprises the raw materials such as arbutin, hydroquinone, kojic acid, fruit acid.For example: Chinese patent application number is " 200910040669.2 ", and patent name is: " a kind of whitening spot-relieving cream cosmetic and preparation method thereof " discloses a kind of whitening spot-relieving cream cosmetic, comprises following component: A, main body Whitening, spot component; B, auxiliary Whitening, spot component; C, oil phase components; D, water component; E, thickening stabilization component; F, auxiliary agent component.Include arbutin in the main body Whitening, spot component wherein.Chinese patent application number is " 98807488.5 ", patent name is: " cosmetic composition that comprises brightening agent and remover " discloses a kind of cosmetic composition of local application, and said composition includes raw material Arctostaphylos ura-ursi extract, arbutin, hydroquinone, kojic acid and malic acid etc.Chinese patent application number is " 200410051908.1 ", and patent name is: " FUHE MEIBAI QUBAN YE " discloses a kind of FUHE MEIBAI QUBAN YE, and this FUHE MEIBAI QUBAN YE includes kojic acid, caffeic acid component.Chinese patent application number is " 200680056933.3 ", and patent name is: " skin lightening compositions that is used for hyperpigmented skin " discloses a kind of compositions, and said composition includes the raw materials such as arbutin, Arctostaphylos ura-ursi extract.
The cosmetics that contain above-mentioned whitening raw material also can cause certain side effect to skin when producing white-skinned face function.For example: arbutin has the photosensitivity of height, easily variable color; Hydroquinone causes that easily local skin is rubescent; Kojic acid itself is unstable, and is easy to change, needs to add a large amount of antioxidant and UV absorbent in formula system; Fruit acid is without direct whitening function, and indirectly whitening has larger stimulation and strips off effect skin.
Therefore, there is prior art this to be made improvement, for example: Chinese patent application number is " 200410051195.9 ", patent name is: " the sharp white moisturizing skin protection cosmetics that does not contain essence, pigment, mineral oil, antiseptic " discloses a kind of cosmetics, these cosmetics can strengthen whitening to human body skin, in order to be effective and without potential threat, safety is good.Chinese patent application number is " 200910195357.9 ", patent name is: " a kind of cosmetic composition with effect of scavenging radical " discloses a kind of cosmetic composition, said composition can reduce external factor to the invasion and attack of skin, smooth away wrinkles thereby reach, keep the moisture of skin abundance and the purpose of delay skin aging.But this technology only solves the problem of skin-whitening from an approach.
In sum, existing skin-lightening cosmetic is of a great variety, and each is variant for its effect, and it is slow mostly to take effect, and skin is caused certain side effect, and safety has much room for improvement.And a kind of or two approach of whitening are considered in existing whitening product design usually, do not have by comprehensively considering the whitening approach of three aspects:, namely melanic generation is suppressed, also the melanin that has generated is reduced, again the melanin transfer that has generated is suppressed to reach comprehensive whitening function.Wherein the overwhelming majority single comes whitening for check melanin, namely or blocking-up DOPA quinone active by restraint of tyrosinase is transformed into melanin, or for established melanin, shift to reach whitening effect by check melanin to skin surface cell, the effect of whitening product can not be shown more fully.
Therefore, develop a kind of composite reactive composition of formation and transfer of from many aspects check melanin, it is single to solve on the market whitening approach, whitening effect is of short duration, unconspicuous problem, the instant effect of while product, use has no side effect, safety is good, and the whitening and speckle dispelling product that really reaches permanent Whitening, spot effect is the place of the object of the invention.
Summary of the invention
First technical problem that the present invention will solve provides the Whitening, spot compositions.Said composition has solved that existing whitening product approach is single, and whitening effect is of short duration, the not obvious and slow problem that takes effect; Use simultaneously to have no side effect, safety is good; Can reach permanent Whitening, spot effect.
Second technical problem that the present invention will solve provides the skin care item that contain the Whitening, spot cosmetic composition.
The 3rd technical problem that the present invention will solve provides the preparation method of the skin care item that contain the Whitening, spot cosmetic composition.
For solving above-mentioned first technical problem, Whitening, spot cosmetic composition of the present invention comprises the raw material of following parts by weight:
0.5～20 part of nicotiamide,
0.1～15 part of AA 2G,
0.1～10 part of yeast extract,
0.05～10 part of sodium lactate/gluconic acid sodium salt,
0.01～3.5 part of sodium hydroxide;
10～60 parts in water.
Described yeast extract is the commercially available prod; Preferably, amino acid content is more than 30% in the described yeast extract, and total protein content is more than 50%, and nucleotide content is more than 10%.
Preferably, 20 parts of nicotiamide, 10 parts of AA 2Gs, 5 parts of yeast extracts, 5 parts of sodium lactate/gluconic acid sodium salts, 2.7 parts of sodium hydroxide; 57 parts in water.
For solving above-mentioned second technical problem, a kind of essence that contains above-mentioned Whitening, spot cosmetic composition of the present invention comprises the raw material of following percentage by weight:
GI CD-10 10～30％，
Butanediol 5～30%,
Glycerol 5%,
Gransurf 50C 0.5～1.5％，
PE 9010 0.6％，
Gransurf 67 0.5～1.5％，
CM040 1～5％，
GTCC 1～4％，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil VX-401 2.5％，
Whitening, spot compositions 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
Preferably, described Radix Ginseng extract is the Radix Ginseng root extract.
Preferably, described Fructus Pruni pseudocerasi extract is the gean berry extract.
Preferably, described Herba Saxifragae extract is the aaron's beard extract.
For solving above-mentioned second technical problem, a kind of nourishing cream that contains above-mentioned Whitening, spot cosmetic composition of the present invention comprises the raw material of following percentage by weight:
Olivem 1000 3％，
E165 0.5～4％，
Cera Flava 1%,
Behenyl alcohol 0.1～2%,
Squalane 5%,
CM040 1～5％，
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5～6%,
Butanediol 6%,
Acritamer 940 0.1～1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Herba Saxifragae extract 0.1,
Fructus Pruni pseudocerasi extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
Preferably, described Fructus Pruni pseudocerasi extract is the gean berry extract.
Preferably, described Herba Saxifragae extract is the aaron's beard extract.
For solving above-mentioned second technical problem, a kind of gentle skin liquid that contains above-mentioned Whitening, spot cosmetic composition of the present invention comprises the raw material of following percentage by weight:
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5％，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04％，
Add water to 100%.
Preferably, described Fructus Pruni pseudocerasi extract is the gean berry extract.
Preferably, described Herba Saxifragae extract is the aaron's beard extract.
For solving above-mentioned the 3rd technical problem, a kind of preparation method that contains the essence of Whitening, spot cosmetic composition of the present invention comprises the steps:
1) take by weighing the raw material of following percentage by weight:
GI CD-10 10～30％，
Butanediol 5～30%,
Glycerol 5%,
Gransurf 50C 0.5～1.5％，
PE 9010 0.6％，
Gransurf 67 0.5～1.5％，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%;
2) with GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 mix and blends 25～50 minutes, get milky paste A;
3) Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate are heated to 50 ℃ of fully fusings, join among the above-mentioned milky paste A, be stirred to mix homogeneously; Get mixture B
4) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
5) with mixture B and mixture C mixing and stirring, must contain the essence of Whitening, spot cosmetic composition.
For solving above-mentioned the 3rd technical problem, a kind of preparation method that contains the nourishing cream of Whitening, spot cosmetic composition of the present invention comprises the steps:
1) take by weighing the raw material of following percentage by weight:
Olivem 1000 3％，
E165 0.5～4％，
Behenyl alcohol 0.1～2%,
Squalane 5%,
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5～6%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.1～1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Herba Saxifragae extract 0.1,
Fructus Pruni pseudocerasi extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%;
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 75～85 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 75～85 ℃, get mixture E;
4) mixture D is joined in the mixture E, stir emulsifying 4～6 minutes, be cooled to 40～50 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, get a kind of nourishing cream that contains the Whitening, spot cosmetic composition.
For solving above-mentioned the 3rd technical problem, a kind of preparation method that contains the gentle skin liquid of Whitening, spot cosmetic composition of the present invention comprises the steps:
1) take by weighing the raw material of following percentage by weight:
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5％，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04％，
Add water to 100%;
2) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, get mixture G;
3) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, get mixture H;
4) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
In of the present invention, the term implication of trade name sign is as follows:
Described " sodium lactate/gluconic acid sodium salt " is the mixture of sodium lactate and gluconic acid sodium salt, trade name PRASAL MOISTXS.
The international cosmetic raw material called after of described " GI CD-10 ": " encircling five polydimethylsiloxane, the poly-first siloxanes of stearic oxygen/dimethione copolymer, polydimethylsiloxane ".The manufacturer for example has: U.S.'s Grant chemical company.The wt% component is: encircle five polydimethylsiloxane 87.0～91.0; The poly-first siloxanes of stearic oxygen/dimethione copolymer 9.0～10.0; Polydimethylsiloxane 1.0～2.0.
The international cosmetic raw material called after of described " Gransurf 50C ": " polydimethylsiloxane, PEG/PPG-18/18 polydimethylsiloxane ".The manufacturer for example has: U.S. Grant chemical company.
The international cosmetic raw material called after of described " PE 9010 ": " phenoxyethanol/Sensiva SC50 ".The manufacturer for example has: German Shu Mei chemical company.
The international cosmetic raw material called after of described " Gransurf 67 ": " KF6017 ".The manufacturer for example has: U.S. Grant chemical company.
The international cosmetic raw material called after of described " CM040 ": " encircling five polydimethylsiloxane ".The manufacturer for example has: German watt is digested, DOW CORNING organosilicon, Japanese SHIN-ETSU HANTOTAI chemistry.
The international cosmetic raw material called after of described " GTCC ": " caprylic/capric triglyceride ".The manufacturer for example has: German Kening Co.,Ltd.
The international cosmetic raw material called after of described " Gransil VX-401 ": " stearic oxygen gathers first siloxanes/dimethione copolymer ".The manufacturer for example has: U.S. Grant chemical company.
The international cosmetic raw material called after of described " Olivem 1000 ": " the smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis ".The manufacturer for example has: Italian B﹠amp; T company.
The international cosmetic raw material called after of described " E165 ": " PEG-100 stearate/glyceryl stearate ".The manufacturer for example has: section is peaceful, match Bick, Britain's standing grain are large.
The international cosmetic raw material called after of described " MG-60 ": " Fructus Hordei Germinatus oligose glycosides/hydrogenated starch hydrolysate ".The manufacturer for example has: Japanese woods is former.
The international cosmetic raw material called after of described " antiseptic K350 ": " phenoxyethanol/methyl hydroxybenzoate/ethyl hydroxybenzoate/Sensiva SC50 ".The manufacturer for example has: German Shu Mei.
The international cosmetic raw material called after of described " DC2501 ": " two-PEG-18 methyl ether dimethylsilane ".The manufacturer for example has: Dow corning.
The international cosmetic raw material called after of described " HPS ": " cocos nucifera oil alcohol ether-7/PPG-1-PEG-9 lauryl glycol ether/Cremophor RH40 ".The manufacturer for example has: German section is peaceful.
Described " butanediol ", " glycerol ", " hydrogenated soy phosphatidyl choline ", " dl-alpha-tocopherol acetate " " Radix Ginseng extract " " Radix Ginseng extract ", " Fructus Pruni pseudocerasi extract ", " gean berry extract " " glycyrrhizic acid dipotassium ", " Herba Saxifragae extract ", " aaron's beard extract ", " xanthan gum ", " Cera Flava ", " behenyl alcohol ", " squalane ", " Acritamer 940 ", " disodium EDTA ", " essence " is existing commercially available prod.
The present invention has following beneficial effect:
1) described Whitening, spot cosmetic composition and cosmetics thereof can be by generation, the transfers of many-sided inhibition or prevention dermal melanin; Can promote the synthetic of skin collagen, replenish skin-nourishing, delay skin aging;
2) can reach fast and effectively whitening effect according to Whitening, spot cosmetic composition of the present invention.This complex can solve that the whitening active component easily decomposes, easily oxidation, the problem such as easy to change, has reduced light, heat to the impact of functional component, makes its activity decreased.
3) product of the present invention is more safer than the whitening agent of other types, can provide skin required nutritional labeling simultaneously; Its slow release method can make whitening effect more lasting.
Description of drawings
Below in conjunction with accompanying drawing the specific embodiment of the present invention is described in further detail
Fig. 1 is the embodiment of the invention 7 product efficacy test melanin content mutation analysis figure;
Fig. 2 is the embodiment of the invention 7 product efficacy test skin brightness (L) variation diagram.
The specific embodiment
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
0.5 part of nicotiamide, 0.1 part of AA 2G, 0.1 part of yeast extract,
0.05 part of sodium lactate/gluconic acid sodium salt, 0.01 part of sodium hydroxide; 10 parts in water.
Described yeast extract is the commercially available prod, wherein, and amino acid content 32%, total protein content 54.7%, nucleotide content 12.3%.
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
20 parts of nicotiamide, 15 parts of AA 2Gs, 10 parts of yeast extracts,
10 parts of sodium lactate/gluconic acid sodium salts, 3.5 parts of sodium hydroxide; 60 parts in water.
Described yeast extract is the commercially available prod; Wherein, amino acid content 30.5%, total protein content 51.6%, nucleotide content 11.4%.
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
10 parts of nicotiamide, 7 parts of AA 2Gs, 5 parts of yeast extracts,
5 parts of sodium lactate/gluconic acid sodium salts, 2 parts of sodium hydroxide; 35 parts in water.
Described yeast extract is the commercially available prod; Wherein amino acid content 30.9%, total protein content 52.9%, nucleotide content 10.7%.
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
20 parts of nicotiamide, 10 parts of AA 2Gs, 5 parts of yeast extracts,
5 parts of sodium lactate/gluconic acid sodium salts, 2.7 parts of sodium hydroxide; 57 parts in water.
Described yeast extract is the commercially available prod; Wherein amino acid content is more than 33.1%, total protein content 50.5%, nucleotide content 11%.
Embodiment 5
A kind of essence that contains the Whitening, spot cosmetic composition of embodiment 1 comprises the raw material of following percentage by weight:
GI CD-10 10％，
Butanediol 5%,
Glycerol 5%,
Gransurf 50C 0.5％，
PE 9010 0.6％，
Gransurf 67 0.5％，
Dl-alpha-tocopherol acetate 0.1%,
Gransil VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Gean berry extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Aaron's beard extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
The preparation method of above-mentioned essence comprises the steps:
1) with GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 mix and blends 10～70 minutes, gets milky paste A;
2) Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate are mixed and heated to 50 ℃ and dissolve fully, then join among the above-mentioned milky paste A, be stirred to mix homogeneously; Get mixture B
3) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
4) with mixture B and mixture C mixing and stirring, must contain the essence of Whitening, spot cosmetic composition.
Embodiment 6
A kind of essence that contains the Whitening, spot cosmetic composition of embodiment 2 comprises the raw material of following percentage by weight:
GI CD-10 30％，
Butanediol 30%,
Glycerol 5%,
Gransurf 50C 1.5％，
PE 9010 0.6％，
Gransurf 67 1.5％，
CM040 5％，
Dl-alpha-tocopherol acetate 0.5%,
Gransil VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Gean berry extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
The preparation method of above-mentioned essence comprises the steps:
1) with GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 mix and blends 25 minutes, gets milky paste A;
2) with Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate mix homogeneously, join among the above-mentioned milky paste A, be stirred to fully dissolving; Get mixture B
3) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
4) with mixture B and mixture C mixing and stirring, must contain the essence of Whitening, spot cosmetic composition.
Embodiment 7
A kind of essence that contains the Whitening, spot cosmetic composition of embodiment 4 comprises the raw material of following percentage by weight:
GI CD-10 20％，
Butanediol 17%,
Glycerol 5%,
PE 9010 0.6％，
Gransurf 67 1％，
Dl-alpha-tocopherol acetate 0.3%,
Gransil VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Gean berry extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Aaron's beard extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
The preparation method of above-mentioned essence comprises the steps:
1) with GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 mix and blends 70 minutes, gets milky paste A;
2) with Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate mix homogeneously, join among the above-mentioned milky paste A, be stirred to fully dissolving; Get mixture B
3) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
4) with mixture B and mixture C mixing and stirring, must contain the essence of Whitening, spot cosmetic composition.
Embodiment 8
A kind of nourishing cream that contains embodiment 3 Whitening, spot cosmetic compositions comprises the raw material of following percentage by weight:
Olivem 1000 3％，
E165 0.5％，
Behenyl alcohol 0.1%,
Squalane 5%,
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.1%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Aaron's beard extract 0.1,
Gean berry extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
The preparation method of above-mentioned nourishing cream comprises the steps:
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 75 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 75 ℃, get mixture E;
4) mixture D is joined in the mixture E, stirred 4 minutes, be cooled to 40 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, must contain the nourishing cream of Whitening, spot cosmetic composition.
Embodiment 9
A kind of nourishing cream that contains embodiment 4 Whitening, spot cosmetic compositions comprises the raw material of following percentage by weight:
Olivem 1000 3％，
Squalane 5%,
CM040 5％，
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 6%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Aaron's beard extract 0.1,
Gean berry extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
The preparation method of above-mentioned nourishing cream comprises the steps:
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 85 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 85 ℃, get mixture E;
4) mixture D is joined in the mixture E, stirred 6 minutes, be cooled to 50 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, must contain the nourishing cream of Whitening, spot cosmetic composition.
Embodiment 10
A kind of nourishing cream that contains embodiment 4 Whitening, spot cosmetic compositions comprises the raw material of following percentage by weight:
Olivem 1000 3％，
Squalane 5%,
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 3%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.5%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Aaron's beard extract 0.1,
Gean berry extract 0.1,
Essence PF16010D 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
Described essence PF16010D is the commercial goods, for example manufacturer Germany Wei Shasi essence corporation.
The preparation method of above-mentioned nourishing cream comprises the steps:
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 80 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, ethylenediaminetetraacetic acid disodium salt, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 80 ℃, get mixture E;
4) mixture D is joined in the mixture E, stirred 5 minutes, be cooled to 45 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, must contain the nourishing cream of Whitening, spot cosmetic composition.
Embodiment 11
A kind of gentle skin liquid that contains the Whitening, spot cosmetic composition of embodiment 1 comprises the raw material of following percentage by weight:
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1％，
Aaron's beard extract 0.01%,
Gean berry extract 0.1%,
Essence PF1601610D 0.01%,
HPS 0.04％，
Add water to 100%.
The preparation method of above-mentioned gentle skin liquid comprises the steps:
1) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, get mixture G;
2) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, get mixture H;
3) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
Embodiment 12
A kind of gentle skin liquid that contains the Whitening, spot cosmetic composition of embodiment 3 comprises the raw material of following percentage by weight:
DC2501 5％，
Disodium EDTA 0.05%,
Xanthan gum 0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 1.5％，
Aaron's beard extract 0.5%,
Gean berry extract 0.5%,
Essence PF1601610D 0.01%
HPS 0.04％，
Add water to 100%.
The preparation method of above-mentioned gentle skin liquid comprises the steps:
1) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, get mixture G;
2) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, get mixture H;
3) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
Embodiment 13
A kind of gentle skin liquid that contains the Whitening, spot cosmetic composition of embodiment 4 comprises the raw material of following percentage by weight:
Disodium EDTA 0.05%,
Xanthan gum 0.25%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 1％，
Aaron's beard extract 0.3%,
Gean berry extract 0.3%,
Essence PF1601610D 0.01%
HPS 0.04％，
Add water to 100%.
The preparation method of above-mentioned gentle skin liquid comprises the steps:
1) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, get mixture G;
2) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, get mixture H;
3) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
Whitening, spot cosmetic composition experiment effect test report is as follows:
One, safety experiment
1, experimental principle
Human experimentation is chosen common volunteer and is formed tested crowd, divides 4 groups; Choose volunteer's number 15 people for every group, wherein the male is 4,11 of women, and the age, test subject used Whitening, spot cosmetic composition skin of the present invention untoward reaction whether to occur between 20～40 years old.
2, experimental technique
The experiment position: the left and right arm of experimenter inboard is apart from palm base portion 5cm place, and each determines that the area of 4 * 4cm size is as the experiment position.
Prepare before the experiment: before every group of experimenter smears respectively the embodiment of the invention 1,2,3,4 products, will test first the position and clean, and smear after drying, it is inboard to be applied in left arm inboard and right arm.
3, experimental period: sooner or later respectively smear once follow-on test 1 month every day.
4, result of the test is as follows:
Two, restraint of tyrosinase activity or blocking oxide chain prevent that melanin from generating test
1, experimental principle
Tryrosinase is added in its substrate (tyrosine), estimate the Whitening, spot cosmetic composition to the suppression ratio of tryrosinase by measuring in the above-mentioned system in the whitening agent that adds variable concentrations and the blank group melanin intermediate (dopachrome) in the absorbance at 475nm place.Thereby determine the white-skinned face function of Whitening, spot cosmetic composition of the present invention.
2, experimental apparatus and sample
Instrument: ultraviolet spectrophotometer (UV-4501S, the production of Gangdong, Tianjin development in science and technology company limited), analytical balance (TE214S, Germany Sai Duolisi produces), TYR (Sigma), tryrosinase (self-control, 0.07mg/m1), the PH6.8 phosphate buffer solution.
3, experiment contrast
The 1st group of testing sample use-case 1 product; The 2nd group of testing sample use-case 2 products; The 3rd group of testing sample use-case 3 products; The 4th group of testing sample use-case 4 products.Embodiment 1 product in Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions is used in the 5th group of testing sample examination.
4, experimental technique
Accurately draw 1,2,3,4 group reaction liquid, mixing by table.20 ℃ of constant temperature after 2.5 hours, are transferred to rapidly in the 3ml cuvette, place the 475nm place to measure absorbance A, to be measured group of sample joined in four groups of solution cultivate, and determine respectively A1, A2, A3, A4, and its meansigma methods is asked in parallel laboratory test 3 times.Be calculated as follows tyrosinase inhibition rate:
A1, A2, A3, A4 are respectively in the table 1,2,3, No. 4 reactant liquor and to be measured group of solution in 20 ℃ in the formula, after 3.5 hours, and the absorbance under the 475nm wavelength.
The 1st group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 1st group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 2nd group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 2nd group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 3rd group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 3rd group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 4th group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 4th group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 5th group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 5th group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
5, experiment detects
Use ultraviolet spectrophotometer to measure the ultraviolet absorptivity at 475nm place take TYR as substrate.
6, result of the test
| Project | The 1st group | The 2nd group | The 3rd group | The 4th group | The 5th group |
| Average suppression ratio % | 45.6 | 78.5 | 90.6 | 96.8 | 83.1 |
Above experimental result has shown that Whitening, spot cosmetic composition of the present invention is can restraint of tyrosinase active, prevents that melanin from generating.And result of the test also shows, wherein the inhibition of the 4th group of testing sample is than other prescription unexpectedly optimal effectiveness intentionally, up to 96.8%.In addition, 1 pair of tryrosinase of embodiment has certain inhibitory action in the 5th group of testing sample Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions.
Three, melanin reduction test
1, experimental principle
Experiment in vitro carries out reduction to established melanocyte by experiment, then observes the melanoma cell change color.Thereby determine the vat black pigment effect of compositions.
2, experimental technique
The B16 melanoma cell, embodiment 1 solution in embodiment 1,2,3,4, Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions, MEM culture fluid.
B16 melanotic tumor cell is cultivated 24h in culture fluid, then add 1,3-2-N-dimethylpurine and continue constant temperature culture 24h.
Whitening, spot cosmetic composition 5ml joined respectively contain in the melanomatous MEM test-tube culture medium of B16 (containing 10%FBS) and cultivate, 37 ℃ of constant temperature are cultivated 28h, use at last the TCA dissolved cell, and measure melanin content in the cell.The melanin synthetic ratio of untreated cell is calculated as 100%.
3, result of the test
Above experimental result has shown that Whitening, spot cosmetic composition of the present invention has reproducibility to established melanin, can be with established melanin reduction desalination.And result of the test shows that also the 4th group of testing sample also has unexpected optimal effectiveness to melanic reduction than other prescription.Equally, embodiment 1 sample is very weak to melanic reducing power in the 5th group of testing sample Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions.
Four, suppress established melanin transfer to the epidermis cell test
1, experimental principle
Melanocyte can produce melanin, and melanin granule shifts to epithelial cells by the dendritic projection of melanocyte, and the melanin granule that is transferred to epithelial cells goes upward to horny layer with epidermis cell, thereby forms mottle at skin.Therefore, to the epidermis cell transmission, solve melanin transfer by the check melanin granule.
2, experimental technique
With epithelial cells and melanocyte co-cultivation, to be measured group of solution was constant temperature culture 6 days more than adding respectively in culture.The blank group only is epithelial cells and melanocyte co-cultivation.
4, result of the test
| Matched group | The 1st group | The 2nd group | The 3rd group | The 4th group | The 5th group | |
| Melanin content % | 86.4 | 76.8 | 45.8 | 53.3 | 32.7 | 74.5 |
| |
0 | 11.1 | 47.0 | 38.3 | 62.1 | 5.8 |
Above data show that this Whitening, spot cosmetic composition has the effect that obvious check melanin granule shifts to epidermis.And wherein the inhibition of the 4th group of testing sample is than other prescription unexpectedly optimal effectiveness intentionally, and its suppression ratio is up to 62.1%.And the 5th group of testing sample only has 5.8% to the suppression ratio of melanin transfer.
Whitening effect test between commercially available whitening essence sample A and the embodiment of the invention 7 sample B
1, experimental principle
Human experimentation is chosen common volunteer and is formed tested crowd, divides 4 groups; Choose volunteer's number 15 people for every group, wherein the male is 4,11 of women, and the age, test subject made the variation of the front and back skin color that applies some make up between 20～40 years old, thereby determined the white-skinned face function of Whitening, spot cosmetic composition of the present invention.
2, experimental apparatus and sample
Instrument: dermal melanin and haemachrome tester (Mexameter MX18, German CK electronics corporation produces); Lab color difference meter (MPA9, German CK electronics corporation produces).
Sample: commercially available whitening essence sample A (containing the arbutin whitening composition), the embodiment of the invention 7 outturn sample B.
Testing location: plant resources research and development key lab of Beijing Technology and Business University
3, experiment crowd and testing time
Volunteer referring to experiment divides 3 groups, every group of totally 15 people, and wherein the male is 4,11 of women, the age was at 20～40 years old.The 1st group is the blank group; Test commercially available whitening essence sample A for the 2nd group; The 3rd group of test embodiment of the invention 7 outturn sample B;
Volunteer service time: respectively smear once every day sooner or later;
Testing time is one month.
4, experimental technique
Before the experimenter smears sample, will try first the experiment position and clean, smear sample after drying.The left and right arm of experimenter inboard is apart from palm base portion 5cm place, and each determines the area of 4 * 4cm size as the experiment position, and sample is applied in the left arm inboard, and sample B is applied in the right arm inboard.
The experimenter smears dosage in each test block be 50 μ L/ time (about two of disposable test tube), and respectively smear once every day sooner or later.Experimental session, the experimenter can not smear other any cosmetics at the experiment position.
5, experiment detects
The experimenter make continuously apply some make up after same time weekly, use dermal melanin and haemachrome tester and Lab color difference meter to test the variation of skin color, average.
6, result of the test
Experimenter's melanin content is changed drawing, see accompanying drawing 1.1 as can be known with reference to the accompanying drawings, and commercially available sample A and sample B of the present invention all have preferably check melanin ability, and the effect that the check melanin of sample B generates slightly is better than sample A, and blank group has clear improvement.
Experimenter's skin brightness (L) value is changed drawing, see accompanying drawing 2,2 as can be known with reference to the accompanying drawings, and commercially available sample A and sample B of the present invention all have the ability of better increase skin brightness, and the effect of sample B is better than sample A, and blank group has clear improvement.
Obviously, the above embodiment of the present invention only is for example of the present invention clearly is described, and is not to be restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here can't give all embodiments exhaustive.Everyly belong to the row that apparent variation that technical scheme of the present invention extends out or change still are in protection scope of the present invention.
Claims (2)
1. a Whitening, spot cosmetic composition is characterized in that, is comprised of the raw material of following parts by weight:
0.5～20 part of nicotiamide,
0.1～15 part of AA 2G,
0.1～10 part of yeast extract,
0.05～10 part of sodium lactate/gluconic acid sodium salt,
0.01～3.5 part of sodium hydroxide,
10～60 parts in water.
2. described Whitening, spot cosmetic composition according to claim 1 is characterized in that, is comprised of the raw material of following parts by weight: 20 parts of nicotiamide, 10 parts of AA 2Gs, 5 parts of yeast extracts, 5 parts of sodium lactate/gluconic acid sodium salts, 2.7 parts of sodium hydroxide; 57 parts in water.
3. described Whitening, spot cosmetic composition according to claim 1 is characterized in that amino acid content is more than 30% in the described yeast extract, and total protein content is more than 50%, and nucleotide content is more than 10%.
4. an essence that contains just like arbitrary described Whitening, spot cosmetic composition among the claim 1-3 is characterized in that, comprises the raw material of following percentage by weight:
GI CD-10 10～30%，
Butanediol 5～30%,
Glycerol 5%,
Gransurf 50C 0.5～1.5%，
PE 9010 0.6%,
Gransurf 67 0.5～1.5%,
CM040 1～5%,
GTCC 1～4%，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil VX-401 2.5%,
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%;
International cosmetic raw material called after ring five polydimethylsiloxane of described GI CD-10, the poly-first siloxanes of stearic oxygen/dimethione copolymer and polydimethylsiloxane;
International cosmetic raw material called after polydimethylsiloxane and the PEG/PPG-18/18 polydimethylsiloxane of described Gransurf 50C;
International cosmetic raw material called after phenoxyethanol/Sensiva SC50 of described PE 9010;
The international cosmetic raw material called after PEG-10 polydimethylsiloxane of described Gransurf 67;
International cosmetic raw material called after ring five polydimethylsiloxane of described CM040;
The international cosmetic raw material called after caprylic/capric triglyceride of described GTCC;
The poly-first siloxanes of the stearic oxygen of the international cosmetic raw material called after of described Gransil VX-401/dimethione copolymer.
5. essence according to claim 4 is characterized in that, described Radix Ginseng extract is the Radix Ginseng root extract.
6. essence according to claim 4 is characterized in that, described Fructus Pruni pseudocerasi extract is the gean berry extract.
7. essence according to claim 4 is characterized in that, described Herba Saxifragae extract is the aaron's beard extract.
8. a gentle skin liquid that contains just like arbitrary described Whitening, spot cosmetic composition among the claim 1-3 is characterized in that, comprises the raw material of following percentage by weight:
DC2501 1～5%，
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5%，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04%，
Add water to 100%;
The international cosmetic raw material called after of described DC2501 is two-PEG-18 methyl ether dimethylsilane;
International cosmetic raw material called after phenoxyethanol/methyl hydroxybenzoate of described antiseptic K350/ethyl hydroxybenzoate/Sensiva SC50;
International cosmetic raw material called after Fructus Hordei Germinatus oligose glycosides/hydrogenated starch hydrolysate of described MG-60;
The international cosmetic raw material called after cocos nucifera oil alcohol ether of described HPS-7/PPG-1-PEG-9 lauryl glycol ether/Cremophor RH40.
9. gentle skin liquid according to claim 8 is characterized in that, described Fructus Pruni pseudocerasi extract is the gean berry extract.
10. gentle skin liquid according to claim 8 is characterized in that, described Herba Saxifragae extract is the aaron's beard extract.
11. the preparation method of essence as claimed in claim 4 is characterized in that, comprises the steps:
1) takes by weighing raw material by described percentage by weight;
2) with GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 mix and blends 25～50 minutes, get milky paste A;
3) Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate are heated to 50 ℃ of fully fusings, join among the above-mentioned milky paste A, be stirred to mix homogeneously; Get mixture B;
4) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
5) with mixture B and mixture C mixing and stirring, must contain the essence of Whitening, spot cosmetic composition.
12. the preparation method of gentle skin liquid as claimed in claim 8 is characterized in that, comprises the steps:
1) takes by weighing raw material by described percentage by weight;
2) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, get mixture G;
3) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, get mixture H;
4) mixture H is joined among the mixture G, stir, namely get the gentle skin liquid that contains the Whitening, spot cosmetic composition.
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| CN102871859B (en) * | 2012-09-21 | 2014-09-24 | 威海百合生物技术股份有限公司 | Two-color double-layer cream rinse and preparation method thereof |
| WO2014103475A1 (en) * | 2012-12-27 | 2014-07-03 | 株式会社林原 | Skin-exterior anti-ageing composition and production method therefor |
| CN103301047B (en) * | 2013-06-25 | 2014-12-17 | 开平市美康泉生物科技有限公司 | Antioxidant moisturizing beautifying gel |
| CN104983630A (en) * | 2015-06-30 | 2015-10-21 | 江苏奇力康皮肤药业有限公司 | Whitening softening lotion and preparation method thereof |
| CN105796474B (en) * | 2016-05-10 | 2018-12-21 | 齐鲁工业大学 | A kind of solid multifunctional mask composition and the method for preparing facial mask |
| CN106511126B (en) * | 2016-10-14 | 2019-12-13 | 广州澳希亚实业有限公司 | Skin-moistening cosmetic composition and preparation method thereof |
| WO2018113634A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids |
| EA201991003A1 (en) | 2016-12-21 | 2019-12-30 | Юнилевер Н.В. | COMPOSITIONS FOR PERSONAL HYGIENE CONTAINING SMALL-SOLUBLE COMPOUNDS |
| WO2018114749A1 (en) | 2016-12-21 | 2018-06-28 | Unilever Plc | Personal care compositions with cystine |
| CN114767562B (en) * | 2016-12-21 | 2024-05-10 | 联合利华知识产权控股有限公司 | Topical skin lightening additives and compositions with amino acids and nicotinamide compounds |
| CN109568203B (en) * | 2018-12-18 | 2021-12-10 | 诺斯贝尔化妆品股份有限公司 | Cosmetic composition with whitening and skin brightening effects |
| CN117815135A (en) * | 2024-01-03 | 2024-04-05 | 华泽睿孚生物技术(广州)有限公司 | Whitening and freckle-removing composition containing North American arbor bark extract |
| CN117694540A (en) * | 2024-02-06 | 2024-03-15 | 北京青颜博识健康管理有限公司 | Natural-source oral whitening composition and application thereof |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 100176 No. 16 West South Road, Beijing, Daxing District Patentee after: Bao Jian (China) Co., Ltd. Address before: 100176 No. 16 West South Road, Beijing, Daxing District Patentee before: Bao Jian (China) daily necessities Co., Ltd. |