CN102366397A - Skin-whitening chloasma-reducing skin-brightening composition, skin care product therewith, and preparation method thereof - Google Patents
Skin-whitening chloasma-reducing skin-brightening composition, skin care product therewith, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a skin-whitening chloasma-reducing skin-brightening composition comprising raw materials of, by weight: 0.5 to 20 parts of nicotinamide, 0.1 to 15 parts of L-ascorbic acid 2-glucoside, 0.1 to 10 parts of an yeast extract, 0.05 to 10 parts of sodium lactate/sodium gluconate, 0.01 to 3.5 parts of sodium hydroxide, and 10 to 60 parts of water. With the composition provided by the invention, appearing and transferring of skin melanin can be inhibited or prevented from various perspectives; skin collagen protein synthesizing can be promoted, skin nutrients can be supplemented, such that skin aging can be retarded; and whitening effects can be achieved rapidly. Whitening active components are likely to be decomposed, oxidized, and discolored. With the composition, the problems can be solved; influences of lights and heat on the effective components are reduced. The product produced by the invention is safer than other whitening agents. With the product produced by the invention, nutrients required by skins can be provided. With a sustained-releasing technology, the whitening effect is more durable.
Description
Technical field
The present invention relates to cosmetic field, especially relate to a kind of Whitening, spot cosmetic composition, the skin care item that contain said composition and method for preparing
Background technology
Melanin is a kind of protein that is present in everyone skin basal layer; Ultraviolet irradiation can make melanin change; Generate a kind of material of protecting skin; Melanin via the moving layer by layer of cellular metabolism, has arrived the skin epidermal area again then, has formed skin problems such as our the present skin darkening of seeing and the colour of skin be irregular.
Because melanic generation mainly is the oxidative chain process that receives tyrosinase activity control, so whitening agent achieves the goal through three kinds of approach usually:
1, be to prevent that through restraint of tyrosinase activity or blocking oxide chain melanin from generating greatly.
2, a part of whitening product can reach the effect of Whitening, spot through the vat black pigment.
3, a part of whitening product can be through suppressing established melanin transfer to epidermis cell, promotes to contain melanic horn cell and come off and reach the skin whitening effect.
At present, the effect raw material that skin-lightening cosmetic added on the market mainly comprises raw materials such as arbutin, hydroquinone, kojic acid, fruit acid.For example: one Chinese patent application number is " 200910040669.2 ", and patent name is: " a kind of whitening spot-relieving cream cosmetic and preparation method thereof " discloses a kind of whitening spot-relieving cream cosmetic, comprises following component: A, main body Whitening, spot component; B, auxiliary Whitening, spot component; C, oil phase components; D, water component; E, thickening stabilization component; F, auxiliary agent component.Include arbutin in the main body Whitening, spot component wherein.One Chinese patent application number is " 98807488.5 "; Patent name is: " cosmetic composition that comprises brightening agent and remover " discloses a kind of cosmetic composition of local application, and said composition includes raw material Arctostaphylos ura-ursi extract, arbutin, hydroquinone, kojic acid and malic acid etc.One Chinese patent application number is " 200410051908.1 ", and patent name is: " FUHE MEIBAI QUBAN YE " discloses a kind of FUHE MEIBAI QUBAN YE, and this FUHE MEIBAI QUBAN YE includes kojic acid, caffeic acid component.One Chinese patent application number is " 200680056933.3 ", and patent name is: " skin lightening compositions that is used for hyperpigmented skin " discloses a kind of compositions, and said composition includes raw materials such as arbutin, Arctostaphylos ura-ursi extract.
The cosmetics that contain the above-mentioned raw material of whitening also can cause certain side effect to skin when producing white-skinned face function.For example: arbutin has the photosensitivity of height, variable color easily; Hydroquinone is prone to cause that local skin is rubescent; Kojic acid itself is unstable, and is easy to change, in formula system, needs to add a large amount of antioxidant and UV absorbent; Fruit acid does not have direct whitening function, can whiten indirectly, and skin is had bigger stimulation and strips off effect.
Therefore; There is prior art this to be made improvement; For example: one Chinese patent application number is " 200410051195.9 ", and patent name is: " the sharp white moisturizing skin protection cosmetics that does not contain essence, pigment, mineral oil, antiseptic " discloses a kind of cosmetics, and these cosmetics can strengthen human body skin whiten; In order to be effective and do not have potential threat, safety is good.One Chinese patent application number is " 200910195357.9 "; Patent name is: " a kind of cosmetic composition with the effect of removing free radical " discloses a kind of cosmetic composition; Said composition can reduce the invasion and attack of external factor to skin; Smooth away wrinkles thereby reach, keep the purpose of competent moisture of skin and delay skin aging.But this technology only solves the problem of skin-whitening from an approach.
In sum, existing skin-lightening cosmetic is of a great variety, and each is variant for its effect and effect, and it is slow to take effect mostly, and skin is caused certain side effect, and safety has much room for improvement.And a kind of or two approach that the common consideration of existing whitening product design is whitened; There is not the approach of whitening through comprehensive consideration three aspects; Promptly melanic generation is suppressed; Also the melanin that has generated is reduced, again the melanin transfer that has generated is suppressed to reach comprehensive whitening function.Wherein the overwhelming majority is that the single inhibition black that is directed against is usually whitened; Promptly be transformed into melanin through restraint of tyrosinase activity or blocking-up DOPA quinone; Or to established melanin; Shift to skin surface cell and reach whitening effect through suppressing melanin, the effect of whitening product can not be shown more fully.
Therefore, develop a kind of composite reactive composition that can suppress melanic formation and transfer from many aspects, it is single to solve the approach of whitening on the market; Whitening effect is of short duration; Unconspicuous problem, the instant effect of while product, use has no side effect; Safety is good, and the whitening and speckle dispelling product that really reaches permanent Whitening, spot effect is the place of the object of the invention.
Summary of the invention
First technical problem that the present invention will solve provides the Whitening, spot compositions.Said composition has solved that existing whitening product approach is single, and whitening effect is of short duration, the not obvious and slow problem that takes effect; Use simultaneously to have no side effect, safety is good; Can reach permanent Whitening, spot effect.
Second technical problem that the present invention will solve provides the skin care item that contain the Whitening, spot cosmetic composition.
The 3rd technical problem that the present invention will solve provides the method for preparing of the skin care item that contain the Whitening, spot cosmetic composition.
For solving above-mentioned first technical problem, Whitening, spot cosmetic composition of the present invention comprises the raw material of following parts by weight:
0.5～20 part of nicotiamide,
0.1～15 part of L-ascorbic acid 2-glucoside,
0.1～10 part of yeast extract,
0.05～10 part of sodium lactate/gluconic acid sodium salt,
0.01～3.5 part of sodium hydroxide;
10～60 parts in water.
Said yeast extract is the commercially available prod; Preferably, amino acid content is more than 30% in the said yeast extract, and total protein content is more than 50%, and nucleotide content is more than 10%.
Preferably, 20 parts of nicotiamide, 10 parts of L-ascorbic acid 2-glucosides, 5 parts of yeast extracts, 5 parts of sodium lactate/gluconic acid sodium salts, 2.7 parts of sodium hydroxide; 57 parts in water.
For solving above-mentioned second technical problem, a kind of essence that contains above-mentioned Whitening, spot cosmetic composition of the present invention comprises following raw materials by weight percent:
GI?CD-10 10～30％，
Butanediol 5～30%,
Glycerol 5%,
Gransurf?50C 0.5～1.5％，
PE?9010 0.6％，
Gransurf?67 0.5～1.5％，
CM040 1～5％，
GTCC 1～4％，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil?VX-401 2.5％，
Whitening, spot compositions 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
Preferably, said Radix Ginseng extract is the Radix Ginseng root extract.
Preferably, said Fructus Pruni pseudocerasi extract is the gean berry extract.
Preferably, said Herba Saxifragae extract is the aaron's beard extract.
For solving above-mentioned second technical problem, a kind of nourishing cream that contains above-mentioned Whitening, spot cosmetic composition of the present invention comprises following raw materials by weight percent:
Olivem?1000 3％，
E165 0.5～4％，
Cera Flava 1%,
Behenyl alcohol 0.1～2%,
Squalane 5%,
CM040 1～5％，
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5～6%,
Butanediol 6%,
Acritamer 940 0.1～1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Herba Saxifragae extract 0.1,
Fructus Pruni pseudocerasi extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
Preferably, said Fructus Pruni pseudocerasi extract is the gean berry extract.
Preferably, said Herba Saxifragae extract is the aaron's beard extract.
For solving above-mentioned second technical problem, a kind of gentle skin liquid that contains above-mentioned Whitening, spot cosmetic composition of the present invention comprises following raw materials by weight percent:
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5％，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04％，
Add water to 100%.
Preferably, said Fructus Pruni pseudocerasi extract is the gean berry extract.
Preferably, said Herba Saxifragae extract is the aaron's beard extract.
For solving above-mentioned the 3rd technical problem, a kind of method for preparing that contains the essence of Whitening, spot cosmetic composition of the present invention comprises the steps:
1) take by weighing following raw materials by weight percent:
GI?CD-10 10～30％，
Butanediol 5～30%,
Glycerol 5%,
Gransurf?50C 0.5～1.5％，
PE?9010 0.6％，
Gransurf?67 0.5～1.5％，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil?VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%;
2) GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 are mixed stirring 25～50 minutes, get milky paste A;
3) Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate are heated to 50 ℃ of fusings fully, join among the above-mentioned milky paste A, be stirred to mix homogeneously; Get mixture B
4) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
5), must contain the essence of Whitening, spot cosmetic composition with mixture B and mixture C mixing and stirring.
For solving above-mentioned the 3rd technical problem, a kind of method for preparing that contains the nourishing cream of Whitening, spot cosmetic composition of the present invention comprises the steps:
1) take by weighing following raw materials by weight percent:
Olivem?1000 3％，
E165 0.5～4％，
Behenyl alcohol 0.1～2%,
Squalane 5%,
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5～6%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.1～1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Herba Saxifragae extract 0.1,
Fructus Pruni pseudocerasi extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%;
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 75～85 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 75～85 ℃, get mixture E;
4) mixture D is joined in the mixture E, stir emulsifying 4～6 minutes, be cooled to 40～50 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, get a kind of nourishing cream that contains the Whitening, spot cosmetic composition.
For solving above-mentioned the 3rd technical problem, a kind of method for preparing that contains the gentle skin liquid of Whitening, spot cosmetic composition of the present invention comprises the steps:
1) take by weighing following raw materials by weight percent:
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5％，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04％，
Add water to 100%;
2) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, mixture G;
3) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, mixture H;
4) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
In of the present invention, the term implication of trade name sign is following:
Said " sodium lactate/gluconic acid sodium salt " is the mixture of sodium lactate and gluconic acid sodium salt, trade name PRASAL MOISTXS.
The international cosmetic material called after of said " GI CD-10 ": " encircle five polydimethylsiloxane, stearic oxygen gathers first siloxanes/dimethione copolymer, polydimethylsiloxane ".The manufacturer for example has: the special chemical company of U.S.'s Glan.The wt% component is: encircle five polydimethylsiloxane 87.0～91.0; Stearic oxygen gathers first siloxanes/dimethione copolymer 9.0～10.0; Polydimethylsiloxane 1.0～2.0.
The international cosmetic material called after of said " Gransurf 50C ": " polydimethylsiloxane, PEG/PPG-18/18 polydimethylsiloxane ".The manufacturer for example has: U.S. Glan specialization company.
The international cosmetic material called after of said " PE 9010 ": " phenoxyethanol/ethylhexyl glycerol ".The manufacturer for example has: German Shu Mei chemical company.
The international cosmetic material called after of said " Gransurf 67 ": " PEG-10 polydimethylsiloxane ".The manufacturer for example has: U.S. Glan specialization company.
The international cosmetic material called after of said " CM040 ": " encircling five polydimethylsiloxane ".The manufacturer for example has: German watt is digested, DOW CORNING organosilicon, Japanese SHIN-ETSU HANTOTAI chemistry.
The international cosmetic material called after of said " GTCC ": " caprylic/capric triglyceride ".The manufacturer for example has: German Kening Co.,Ltd.
The international cosmetic material called after of said " Gransil VX-401 ": " stearic oxygen gathers first siloxanes/dimethione copolymer ".The manufacturer for example has: U.S. Glan specialization company.
The international cosmetic material called after of said " Olivem 1000 ": " the smooth olive oil acid esters of cetearyl alcohol olive oil acid esters/Pyrusussuriensis ".The manufacturer for example has: Italian B&T company.
The international cosmetic material called after of said " E165 ": " PEG-100 stearate/glyceryl stearate ".The manufacturer for example has: section is peaceful, match Bick, Britain's standing grain are big.
The international cosmetic material called after of said " MG-60 ": " Fructus Hordei Germinatus oligose glycosides/hydrogenated starch hydrolysate ".The manufacturer for example has: Japanese woods is former.
The international cosmetic material called after of said " antiseptic K350 ": " phenoxyethanol/methyl hydroxybenzoate/ethyl hydroxybenzoate/ethylhexyl glycerol ".The manufacturer for example has: German Shu Mei.
The international cosmetic material called after of said " DC2501 ": " two-PEG-18 methyl ether dimethylsilane ".The manufacturer for example has: Dow corning.
The international cosmetic material called after of said " HPS ": " cocos nucifera oil alcohol ether-7/PPG-1-PEG-9 lauryl glycol ether/PEG-40 castor oil hydrogenated ".The manufacturer for example has: German section is peaceful.
Said " butanediol "; " glycerol "; " hydrogenated soy phosphatidyl choline "; " dl-alpha-tocopherol acetate " " Radix Ginseng extract " " Radix Ginseng extract "; " Fructus Pruni pseudocerasi extract "; " gean berry extract " " glycyrrhizic acid dipotassium "; " Herba Saxifragae extract "; " aaron's beard extract "; " xanthan gum "; " Cera Flava "; " behenyl alcohol "; " squalane "; " Acritamer 940 "; " disodium EDTA "; " essence " is existing commercially available prod.
The present invention has following beneficial effect:
1) described Whitening, spot cosmetic composition and cosmetics thereof can be through generation, the transfers of many-sided inhibition or prevention dermal melanin; Can promote the synthetic of skin collagen, replenish skin-nourishing, delaying decrepitude of skin;
2) can reach whitening effect fast and effectively according to Whitening, spot cosmetic composition of the present invention.This complex can solve the active component of whitening and be prone to decompose, be prone to oxidation, problem such as easy to change, reduced the influence to functional component of light, heat, makes its active reduction.
3) product of the present invention is more safer than the whitening agent of other types, can provide skin required nutritional labeling simultaneously; Its slow release method can make whitening effect more lasting.
Description of drawings
Do further detailed explanation below in conjunction with the accompanying drawing specific embodiments of the invention
Fig. 1 is the embodiment of the invention 7 product efficacy test melanin content mutation analysis figure;
Fig. 2 is the embodiment of the invention 7 product efficacy test skin brightness (L) variation diagram.
The specific embodiment
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
0.5 part of nicotiamide, 0.1 part of L-ascorbic acid 2-glucoside, 0.1 part of yeast extract,
0.05 part of sodium lactate/gluconic acid sodium salt, 0.01 part of sodium hydroxide; 10 parts in water.
Said yeast extract is the commercially available prod, wherein, and amino acid content 32%, total protein content 54.7%, nucleotide content 12.3%.
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
20 parts of nicotiamide, 15 parts of L-ascorbic acid 2-glucosides, 10 parts of yeast extracts,
10 parts of sodium lactate/gluconic acid sodium salts, 3.5 parts of sodium hydroxide; 60 parts in water.
Said yeast extract is the commercially available prod; Wherein, amino acid content 30.5%, total protein content 51.6%, nucleotide content 11.4%.
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
10 parts of nicotiamide, 7 parts of L-ascorbic acid 2-glucosides, 5 parts of yeast extracts,
5 parts of sodium lactate/gluconic acid sodium salts, 2 parts of sodium hydroxide; 35 parts in water.
Said yeast extract is the commercially available prod; Wherein amino acid content 30.9%, total protein content 52.9%, nucleotide content 10.7%.
A kind of Whitening, spot cosmetic composition comprises the raw material of following parts by weight:
20 parts of nicotiamide, 10 parts of L-ascorbic acid 2-glucosides, 5 parts of yeast extracts,
5 parts of sodium lactate/gluconic acid sodium salts, 2.7 parts of sodium hydroxide; 57 parts in water.
Said yeast extract is the commercially available prod; Wherein amino acid content is more than 33.1%, total protein content 50.5%, nucleotide content 11%.
Embodiment 5
A kind of essence that contains the Whitening, spot cosmetic composition of embodiment 1 comprises following raw materials by weight percent:
GI?CD-10 10％，
Butanediol 5%,
Glycerol 5%,
Gransurf?50C 0.5％，
PE?9010 0.6％，
Gransurf?67 0.5％，
Dl-alpha-tocopherol acetate 0.1%,
Gransil?VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Gean berry extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Aaron's beard extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
The method for preparing of above-mentioned essence comprises the steps:
1) GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 are mixed stirring 10～70 minutes, get milky paste A;
2) Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate are mixed and heated to 50 ℃ and dissolve fully, join then among the above-mentioned milky paste A, be stirred to mix homogeneously; Get mixture B
3) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
4), must contain the essence of Whitening, spot cosmetic composition with mixture B and mixture C mixing and stirring.
Embodiment 6
A kind of essence that contains the Whitening, spot cosmetic composition of embodiment 2 comprises following raw materials by weight percent:
GI?CD-10 30％，
Butanediol 30%,
Glycerol 5%,
Gransurf?50C 1.5％，
PE?9010 0.6％，
Gransurf?67 1.5％，
CM040 5％，
Dl-alpha-tocopherol acetate 0.5%,
Gransil?VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Gean berry extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
The method for preparing of above-mentioned essence comprises the steps:
1) GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 are mixed stirring 25 minutes, get milky paste A;
2) with Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate mix homogeneously, join among the above-mentioned milky paste A, be stirred to dissolving fully; Get mixture B
3) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
4), must contain the essence of Whitening, spot cosmetic composition with mixture B and mixture C mixing and stirring.
Embodiment 7
A kind of essence that contains the Whitening, spot cosmetic composition of embodiment 4 comprises following raw materials by weight percent:
GI?CD-10 20％，
Butanediol 17%,
Glycerol 5%,
Gransurf?50C 1％，
PE?9010 0.6％，
Gransurf?67 1％，
Dl-alpha-tocopherol acetate 0.3%,
Gransil?VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Gean berry extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Aaron's beard extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%.
The method for preparing of above-mentioned essence comprises the steps:
1) GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 are mixed stirring 70 minutes, get milky paste A;
2) with Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate mix homogeneously, join among the above-mentioned milky paste A, be stirred to dissolving fully; Get mixture B
3) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
4), must contain the essence of Whitening, spot cosmetic composition with mixture B and mixture C mixing and stirring.
Embodiment 8
A kind of nourishing cream that contains embodiment 3 Whitening, spot cosmetic compositions comprises following raw materials by weight percent:
Olivem?1000 3％，
E165 0.5％，
Behenyl alcohol 0.1%,
Squalane 5%,
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.1%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Aaron's beard extract 0.1,
Gean berry extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
The method for preparing of above-mentioned nourishing cream comprises the steps:
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 75 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 75 ℃, get mixture E;
4) mixture D is joined in the mixture E, stirred 4 minutes, be cooled to 40 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, must contain the nourishing cream of Whitening, spot cosmetic composition.
Embodiment 9
A kind of nourishing cream that contains embodiment 4 Whitening, spot cosmetic compositions comprises following raw materials by weight percent:
Olivem?1000 3％，
Squalane 5%,
CM040 5％，
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 6%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Aaron's beard extract 0.1,
Gean berry extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
The method for preparing of above-mentioned nourishing cream comprises the steps:
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 85 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 85 ℃, get mixture E;
4) mixture D is joined in the mixture E, stirred 6 minutes, be cooled to 50 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, must contain the nourishing cream of Whitening, spot cosmetic composition.
Embodiment 10
A kind of nourishing cream that contains embodiment 4 Whitening, spot cosmetic compositions comprises following raw materials by weight percent:
Olivem?1000 3％，
Squalane 5%,
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 3%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.5%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Aaron's beard extract 0.1,
Gean berry extract 0.1,
Essence PF16010D 0.06%,
Antiseptic K350 0.7%,
Add water to 100%.
Said essence PF16010D is the commercial goods, for example manufacturer Germany Wei Shasi essence corporation.
The method for preparing of above-mentioned nourishing cream comprises the steps:
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 80 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, ethylenediaminetetraacetic acid disodium salt, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 80 ℃, get mixture E;
4) mixture D is joined in the mixture E, stirred 5 minutes, be cooled to 45 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, must contain the nourishing cream of Whitening, spot cosmetic composition.
Embodiment 11
A kind of gentle skin liquid that contains the Whitening, spot cosmetic composition of embodiment 1 comprises following raw materials by weight percent:
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1％，
Aaron's beard extract 0.01%,
Gean berry extract 0.1%,
Essence PF1601610D 0.01%,
HPS 0.04％，
Add water to 100%.
The method for preparing of above-mentioned gentle skin liquid comprises the steps:
1) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, mixture G;
2) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, mixture H;
3) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
Embodiment 12
A kind of gentle skin liquid that contains the Whitening, spot cosmetic composition of embodiment 3 comprises following raw materials by weight percent:
DC2501 5％，
Disodium EDTA 0.05%,
Xanthan gum 0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 1.5％，
Aaron's beard extract 0.5%,
Gean berry extract 0.5%,
Essence PF1601610D 0.01%
HPS 0.04％，
Add water to 100%.
The method for preparing of above-mentioned gentle skin liquid comprises the steps:
1) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, mixture G;
2) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, mixture H;
3) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
Embodiment 13
A kind of gentle skin liquid that contains the Whitening, spot cosmetic composition of embodiment 4 comprises following raw materials by weight percent:
Disodium EDTA 0.05%,
Xanthan gum 0.25%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 1％，
Aaron's beard extract 0.3%,
Gean berry extract 0.3%,
Essence PF1601610D 0.01%
HPS 0.04％，
Add water to 100%.
The method for preparing of above-mentioned gentle skin liquid comprises the steps:
1) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, mixture G;
2) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, mixture H;
3) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
Whitening, spot cosmetic composition experiment effect test report is following:
One, safety experiment
1, experimental principle
Human experimentation is chosen common volunteer and is formed experimenter crowd, divides 4 groups; Choose volunteer's number 15 people for every group, wherein the male is 4,11 of women, and the age, test subject used Whitening, spot cosmetic composition skin of the present invention untoward reaction whether to occur between 20～40 years old.
2, experimental technique
The experiment position: the left and right arm of experimenter inboard is apart from palm base portion 5cm place, and each confirms that the area of 4 * 4cm size is as the experiment position.
Prepare before testing: before every group of experimenter smears the embodiment of the invention 1,2,3,4 products respectively, will test the position earlier and clean, and smear after drying, and be applied in the inboard and right arm inboard of left arm.
3, experimental period: sooner or later respectively smear once follow-on test 1 month every day.
4, result of the test is following:
Two, restraint of tyrosinase activity or blocking oxide chain prevent that melanin from generating test
1, experimental principle
Tryrosinase is added in its substrate (tyrosine); Estimate the suppression ratio of Whitening, spot cosmetic composition through measuring in the above-mentioned system in the whitening agent that adds variable concentrations and the blank control group melanin intermediate (dopachrome) in the absorbance at 475nm place to tryrosinase.Thereby confirm the white-skinned face function of Whitening, spot cosmetic composition of the present invention.
2, experimental apparatus and sample
Instrument: ultraviolet spectrophotometer (UV-4501S, development in science and technology company limited in Gangdong, Tianjin produce), analytical balance (TE214S, German Sai Duolisi produces), L-tyrosine (Sigma), tryrosinase (self-control, 0.07mg/m1), the PH6.8 phosphate buffer solution.
3, experiment contrast
The 1st group of testing sample use-case 1 product; The 2nd group of testing sample use-case 2 products; The 3rd group of testing sample use-case 3 products; The 4th group of testing sample use-case 4 products.Embodiment 1 product in Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions is used in the 5th group of testing sample examination.
4, experimental technique
Accurately draw 1,2,3,4 group reaction liquid, mixing by table.20 ℃ of constant temperature after 2.5 hours, are transferred to rapidly in the 3ml cuvette, place the 475nm place to measure absorbance A, to be measured group of sample joined in four groups of solution cultivate, and determine A1, A2, A3, A4 respectively, and its meansigma methods is asked in parallel laboratory test 3 times.Be calculated as follows tyrosinase inhibition rate:
A1, A2, A3, A4 are respectively in the table 1,2,3, No. 4 reactant liquor and to be measured group of solution in 20 ℃ in the formula, after 3.5 hours, and the absorbance under the 475nm wavelength.
The 1st group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 1st group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 2nd group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 2nd group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 3rd group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 3rd group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 4th group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 4th group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
The 5th group of solution preparation:
| | Solution | 1 | |
|
|
| 0.1%L-tyrosine | 0.5 | 0 | 0.5 | 0 | |
| The 5th group of |
0 | 0 | 1.0 | 1.0 | |
| Tryrosinase solution | 0.5 | 0.5 | 0.5 | 0.5 | |
| The phosphate buffer solution of PH6.8 | 1.5 | 2.0 | 1.5 | 2.0 | |
| Add up to | 3.5 | 3.5 | 3.5 | 3.5 |
5, experiment detects
With L-tyrosine is that substrate uses ultraviolet spectrophotometer to measure the ultraviolet absorptivity at 475nm place.
6, result of the test
| Project | The 1st group | The 2nd group | The 3rd group | The 4th group | The 5th group |
| Average suppression ratio % | 45.6 | 78.5 | 90.6 | 96.8 | 83.1 |
Above experimental result has shown that Whitening, spot cosmetic composition of the present invention is can restraint of tyrosinase active, prevents that melanin from generating.And result of the test also shows, wherein the inhibition effect of the 4th group of testing sample is than other prescription unexpectedly optimal effectiveness intentionally, up to 96.8%.In addition, 1 pair of tryrosinase of embodiment has certain inhibitory action in the 5th group of testing sample Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions.
Three, melanin reduction test
1, experimental principle
Experiment in vitro carries out reduction through experiment to established melanocyte, observes the MC change color then.Thereby confirm the vat black pigment effect of compositions.
2, experimental technique
The B16 MC, embodiment 1 solution in embodiment 1,2,3,4, Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions, MEM culture fluid.
B16 melanotic tumor cell is cultivated 24h in culture fluid, add 1 then, the 3-2-N-dimethylpurine continues constant temperature culture 24h.
Whitening, spot cosmetic composition 5ml joined respectively contain in the melanomatous MEM test tube of the B16 culture medium (containing 10%FBS) and cultivate, constant temperature is cultivated 28h for 37 ℃, uses the TCA dissolved cell at last, and measures melanin content in the cell.The melanin synthetic ratio of untreated cell is calculated as 100%.
3, result of the test
Above experimental result has shown that Whitening, spot cosmetic composition of the present invention has reproducibility to established melanin, can be with established melanin reduction desalination.And result of the test shows that also the 4th group of testing sample also has unexpected optimal effectiveness to melanic reduction than other prescription.Equally, in the 5th group of testing sample Chinese patent " 200410051908.1 " the composite whitening spot-dispelling compositions embodiment 1 sample to melanic reducing power very a little less than.
Four, suppress established melanin transfer to the epidermis cell test
1, experimental principle
Melanocyte can produce melanin, and melanin granule shifts to epithelial cells through the dendritic projection of melanocyte, and the melanin granule that is transferred to epithelial cells goes upward to horny layer with epidermis cell, thereby on skin, forms mottle.Therefore, through suppressing melanin granule, solve melanin transfer to the epidermis cell transmission.
2, experimental technique
With epithelial cells and melanocyte co-cultivation, to be measured group of solution was constant temperature culture 6 days more than in culture, adding respectively.The blank group is merely epithelial cells and melanocyte co-cultivation.
4, result of the test
| Matched group | The 1st group | The 2nd group | The 3rd group | The 4th group | The 5th group | |
| Melanin content % | 86.4 | 76.8 | 45.8 | 53.3 | 32.7 | 74.5 |
| |
0 | 11.1 | 47.0 | 38.3 | 62.1 | 5.8 |
Above data show that this Whitening, spot cosmetic composition has the effect that obvious inhibition melanin granule shifts to epidermis.And wherein the inhibition effect of the 4th group of testing sample is than other prescription unexpectedly optimal effectiveness intentionally, and its suppression ratio is up to 62.1%.And the 5th group of testing sample has only 5.8% to the suppression ratio of melanin transfer.
Whitening effect test between commercially available whitening essence sample A and the embodiment of the invention 7 sample B
1, experimental principle
Human experimentation is chosen common volunteer and is formed experimenter crowd, divides 4 groups; Choose volunteer's number 15 people for every group, wherein the male is 4,11 of women, and the age, test subject made the variation of the front and back skin color that applies some make up between 20～40 years old, thereby confirmed the white-skinned face function of Whitening, spot cosmetic composition of the present invention.
2, experimental apparatus and sample
Instrument: dermal melanin and haemachrome tester (Mexameter MX18, German CK electronics corporation produces); Lab color difference meter (MPA9, German CK electronics corporation produces).
Sample: commercially available whitening essence sample A (containing the arbutin whitening composition), the embodiment of the invention 7 outturn sample B.
Testing location: plant resources research and development key lab of Beijing Technology and Business University
3, experiment crowd and testing time
Volunteer referring to experiment divides 3 groups, every group of totally 15 people, and wherein the male is 4,11 of women, the age was at 20～40 years old.The 1st group is the blank group; Test commercially available whitening essence sample A for the 2nd group; The 3rd group of test embodiment of the invention 7 outturn sample B;
Volunteer service time: respectively smear once every day sooner or later;
Testing time is one month.
4, experimental technique
Before the experimenter smears sample, will try the experiment position earlier and clean, smear sample after drying.The left and right arm of experimenter inboard is apart from palm base portion 5cm place, and each confirms the area of 4 * 4cm size as the experiment position, and sample is applied in the left arm inboard, and sample B is applied in the right arm inboard.
The experimenter smears dosage in each test block be 50 μ L/ time (about two of disposable test tube), and respectively smear once every day sooner or later.Experimental session, the experimenter can not smear other any cosmetics at the experiment position.
5, experiment detects
The experimenter make continuously apply some make up after the same weekly time, use dermal melanin and haemachrome tester and Lab color difference meter to test the variation of skin color, average.
6, result of the test
Experimenter's melanin content is changed drawing, see accompanying drawing 1.Can know that according to accompanying drawing 1 commercially available sample A and sample B of the present invention all have better inhibited melanin ability, the effect that the inhibition melanin of sample B generates slightly is better than sample A, has clear improvement than blank control group.
Experimenter's skin brightness (L) value is changed drawing, see accompanying drawing 2, can know that according to accompanying drawing 2 commercially available sample A and sample B of the present invention all have the ability of better increase skin brightness, the effect of sample B is better than sample A, has clear improvement than blank control group.
Obviously, the above embodiment of the present invention only be for clearly the present invention is described and is done for example, and be not to be qualification to embodiment of the present invention.For the those of ordinary skill in affiliated field, on the basis of above-mentioned explanation, can also make other multi-form variation or change.Here can't give exhaustive to all embodiments.Everyly belong to the row that conspicuous variation that technical scheme of the present invention extends out or change still are in protection scope of the present invention.
Claims (9)
1. a Whitening, spot cosmetic composition is characterized in that, comprises the raw material of following parts by weight:
0.5～20 part of nicotiamide,
0.1～15 part of L-ascorbic acid 2-glucoside,
0.1～10 part of yeast extract,
0.05～10 part of sodium lactate/gluconic acid sodium salt,
0.01～3.5 part of sodium hydroxide,
10～60 parts in water.
2. according to the said Whitening, spot cosmetic composition of claim 1, it is characterized in that, comprise the raw material of following parts by weight: 20 parts of nicotiamide, 10 parts of L-ascorbic acid 2-glucosides, 5 parts of yeast extracts, 5 parts of sodium lactate/gluconic acid sodium salts, 2.7 parts of sodium hydroxide; 57 parts in water.
3. according to the said Whitening, spot cosmetic composition of claim 1, it is characterized in that amino acid content is more than 30% in the said yeast extract, total protein content is more than 50%, and nucleotide content is more than 10%.
4. an essence that contains above-mentioned Whitening, spot cosmetic composition is characterized in that, comprises following raw materials by weight percent:
GI?CD-10 10～30％，
Butanediol 5～30%,
Glycerol 5%,
Gransurf?50C 0.5～1.5％，
PE?9010 0.6％，
Gransurf?67 0.5～1.5％，
CM040 1～5％，
GTCC 1～4％，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil?VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%;
Preferably, said Radix Ginseng extract is the Radix Ginseng root extract;
Preferably, said Fructus Pruni pseudocerasi extract is the gean berry extract;
Preferably, said Herba Saxifragae extract is the aaron's beard extract.
5. a nourishing cream that contains above-mentioned Whitening, spot cosmetic composition is characterized in that, comprises following raw materials by weight percent:
Olivem?1000 3％，
E165 0.5～4％，
Cera Flava 1%,
Behenyl alcohol 0.1～2%,
Squalane 5%,
CM040 1～5％，
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5～6%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.1～1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Herba Saxifragae extract 0.1,
Fructus Pruni pseudocerasi extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%;
Preferably, said Fructus Pruni pseudocerasi extract is the gean berry extract;
Preferably, said Herba Saxifragae extract is the aaron's beard extract.
6. a gentle skin liquid that contains above-mentioned Whitening, spot cosmetic composition is characterized in that, comprises following raw materials by weight percent:
DC2501 1～5％，
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5％，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04％，
Add water to 100%;
Preferably, said Fructus Pruni pseudocerasi extract is the gean berry extract;
Preferably, said Herba Saxifragae extract is the aaron's beard extract.
7. a method for preparing that contains the essence of Whitening, spot cosmetic composition is characterized in that, comprises the steps:
1) take by weighing following raw materials by weight percent:
GI?CD-10 10～30％，
Butanediol 5～30%,
Glycerol 5%,
Gransurf?50C 0.5～1.5％，
PE?9010 0.6％，
Gransurf?67 0.5～1.5％，
CM040 1～5％，
GTCC 1～4％，
Dl-alpha-tocopherol acetate 0.1～0.5%,
Gransil?VX-401 2.5％，
Whitening, spot cosmetic composition 20%,
Radix Ginseng extract 0.1%,
Fructus Pruni pseudocerasi extract 0.1%,
Glycyrrhizic acid dipotassium 0.03%,
Herba Saxifragae extract 0.1%,
Xanthan gum 0.1%,
Add water to total amount 100%;
2) GI CD-10, butanediol, glycerol, Gransurf 50C, Gransurf 67 are mixed stirring 25～50 minutes, get milky paste A;
3) Gransil VX-401, GTCC, PE 9010, CM040, dl-alpha-tocopherol acetate are heated to 50 ℃ of fusings fully, join among the above-mentioned milky paste A, be stirred to mix homogeneously; Get mixture B
4) Whitening, spot cosmetic composition, Radix Ginseng extract, Fructus Pruni pseudocerasi extract, glycyrrhizic acid dipotassium, Herba Saxifragae extract, xanthan gum and water mixing and stirring are got mixture C;
5), must contain the essence of Whitening, spot cosmetic composition with mixture B and mixture C mixing and stirring.
8. a method for preparing that contains the nourishing cream of Whitening, spot cosmetic composition is characterized in that, comprises the steps:
1) take by weighing following raw materials by weight percent:
Olivem?1000 3％，
E165 0.5～4％，
Cera Flava 1%,
Behenyl alcohol 0.1～2%,
Squalane 5%,
CM040 1～5％，
Hydrogenated soy phosphatidyl choline 0.05%,
Dl-alpha-tocopherol acetate 0.5%,
Palmic acid-2-Octyl Nitrite 0.5～6%,
Glycerol 4%,
Butanediol 6%,
Acritamer 940 0.1～1.0%,
Disodium EDTA 0.05%,
Xanthan gum 0.1%,
Whitening, spot cosmetic composition 10%,
MG-60 0.5％，
Herba Saxifragae extract 0.1,
Fructus Pruni pseudocerasi extract 0.1,
Essence 0.06%,
Antiseptic K350 0.7%,
Add water to 100%;
2) with Olivem 1000, E165, Cera Flava, behenyl alcohol, squalane, CM040, hydrogenated soy phosphatidyl choline, dl-alpha-tocopherol acetate, Palmic acid-2-Octyl Nitrite mixing and stirring, be heated to 75～85 ℃, get mixture D;
3) with glycerol, butanediol, Acritamer 940, disodium EDTA, xanthan gum, Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract mixing and stirring, be heated to 75～85 ℃, get mixture E;
4) mixture D is joined in the mixture E, stir emulsifying 4～6 minutes, be cooled to 40～50 ℃, get mixture F;
5) essence, antiseptic K350, water are joined among the mixture F, stir, get a kind of nourishing cream that contains the Whitening, spot compositions.
9. a method for preparing that contains the gentle skin liquid of Whitening, spot cosmetic composition is characterized in that, comprises the steps:
1) take by weighing following raw materials by weight percent:
DC2501 1～5％，
Disodium EDTA 0.05%,
Xanthan gum 0.1～0.4%,
Glycerol 4%,
Antiseptic K350 0.5%,
Butanediol 6%,
Whitening, spot cosmetic composition 5%,
MG-60 0.1～1.5％，
Herba Saxifragae extract 0.01～0.5%,
Fructus Pruni pseudocerasi extract 0.1～0.5%,
Essence 0.01%,
HPS 0.04％，
Add water to 100%;
2) water, DC2501, disodium EDTA, xanthan gum, glycerol, antiseptic K350, butanediol are mixed, stir and solid phase is dissolved fully, mixture G;
3) Whitening, spot cosmetic composition, MG-60, Herba Saxifragae extract, Fructus Pruni pseudocerasi extract, essence, HPS are mixed, stir and solid phase is dissolved fully, mixture H;
4) mixture H is joined among the mixture G, stir, both must contain the gentle skin liquid of Whitening, spot cosmetic composition.
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