CN108186457A - A kind of melanin composite inhibiting - Google Patents
A kind of melanin composite inhibiting Download PDFInfo
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- CN108186457A CN108186457A CN201810192246.1A CN201810192246A CN108186457A CN 108186457 A CN108186457 A CN 108186457A CN 201810192246 A CN201810192246 A CN 201810192246A CN 108186457 A CN108186457 A CN 108186457A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of melanin composite inhibitings, and including ingredients such as tyrosinase inhibitor, antioxidant, moisturizer, tyrosinase inhibitor such as tribulus terrestris extraction, Paeonol effectively inhibit tyrosinase activity, reduce melanin generation；Adding antioxidant such as carrotene, broussoflavone has good scavenging activated oxygen, mitigates the effect of lipid peroxide damage, and then can reduce the precipitation of skin melanin；Moisturizer hyaluronic acid, the flores aurantii water of addition can infilter skin very well, energy deep water supplement, and skin barrier is formed, has the function that conserve skin, act synergistically between ingredient, free radical can effectively be removed, effectively inhibit tyrosinase activity, and melanin is inhibited to generate and precipitate, applied in cosmetics, the effect that cosmetics well inhibit melanin can be assigned, skin can be enabled more pale, moist.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of melanin composite inhibiting.
Background technology
Melanin is a kind of protein for being present in everyone skin base layer.Ultraviolet irradiation can enable melanin generate
Variation generates a kind of substance for protecting skin, and then melanin and moving layer by layer via cell metabolism, have arrived skin epidermis
Layer forms color spot and the irregular grade skin problems of the colour of skin that we are seen now.In addition, the because tradition of " a white screening three is ugly "
Beauty is read, and Asia women never stops the pursuit of whitening just as the mankind for bright pursuit, and kermes pigment are almost
It is the necessary article of each adult female, has arrived now, even more there is the powdering man that concealer, foundation cream, loose powder, muffin etc. 00 are total
Race whitewashes whitening, presents a false picture of peace and prosperity.In fact, whitening is like to cure the disease, and is taken stopgap measures not as good as effecting a permanent cure, only interior conditioned in skin quality, root
Controlling influences arch-criminal --- the melanin of whitening, and the natural beauty white light that skin can just show really from inside to outside is color.
Many whitening products add violated heavy metal component in the prior art, generate the effect of quick whitening, but this
Heavy metal species are exceeded to lead to skin heavy metal poisoning, and skin is enabled to generate irreversible damage, and with people to naturally into
The favor degree divided increases, and natural whitening composition seems more favourable, sets about from melanin, and research and development, which have, inhibits melanin to reach
To the product of whitening purpose, there is more significant whitening effect, and natural component safety.
Invention content
The purpose of the present invention is to provide a kind of melanin composite inhibiting, by tyrosinase inhibitor, antioxidant,
Collective effect between moisturizer can effectively inhibit the generation of melanin, while also have anti-oxidant, moisturizing effect.
To achieve the above object, the present invention provides following technical solution：
A kind of melanin composite inhibiting includes the component of following mass parts：
Wherein, tyrosinase inhibitor is included in kojic acid, tribulus terrestris extraction, Paeonol, glabridin, asiaticosid
One or more kinds of ingredients；
Antioxidant is then including one kind in carrotene, Chu in fact sub- haematochrome, vitamin C and its derivative, broussoflavone
Or more than one ingredients.
Further, the composition includes the component of following mass parts：
Wherein, tyrosinase inhibitor is included in kojic acid, tribulus terrestris extraction, Paeonol, glabridin, asiaticosid
One or more kinds of ingredients；
Antioxidant is then including one kind in carrotene, Chu in fact sub- haematochrome, vitamin C and its derivative, broussoflavone
Or more than one ingredients.
Further, the composition includes the component of following mass parts：
Wherein, tyrosinase inhibitor is included in kojic acid, tribulus terrestris extraction, Paeonol, glabridin, asiaticosid
One or more kinds of ingredients；
Antioxidant is then including one kind in carrotene, Chu in fact sub- haematochrome, vitamin C and its derivative, broussoflavone
Or more than one ingredients.
In addition, the moisturizer includes one kind in propylene glycol, hyaluronic acid, ceramide, bisabolol, flores aurantii water
Or more than one ingredients；
The preservative includes hydroxy methyl, Phenoxyethanol, Chlorphenesin, potassium sorbate, one kind in pungent glycol or one
Kind or more ingredient；
Composition of the present invention can be used for cosmetics, such as be used for whitening class product as additive.
Compared with prior art, it is the device have the advantages that as follows：
(1) addition tyrosinase inhibitor such as tribulus terrestris extraction, Paeonol effectively inhibits tyrosinase activity, reduces black
Pigment generates；Adding antioxidant such as carrotene, broussoflavone has good scavenging activated oxygen, mitigates lipid peroxide
The effect of damage, and then the precipitation of skin melanin can be reduced；Moisturizer hyaluronic acid, the flores aurantii water of addition can infilter very well
Skin, energy deep water supplement, and skin barrier is formed, have the function that conserve skin；(2) melanin composite inhibiting of the present invention
It acts synergistically between middle tyrosinase inhibitor, antioxidant and moisturizer, can effectively remove free radical, it is anti-oxidant, effectively inhibit
Tyrosinase activity, and then inhibit melanin generation and precipitation, and applied in cosmetics, cosmetics can be assigned and well pressed down
The effect of melanin processed can enable skin more pale, moist.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The preparation of melanin composite inhibiting：
By 15.4 grams of tribulus terrestris extractions, 6.7 grams of broussoflavones, 15.8 grams of flores aurantii water, 0.09 gram of Phenoxyethanol,
62.01 grams of deionized waters are placed in mixer, are uniformly mixed, you can obtain melanin composite inhibiting.
Tyrosinase activity inhibits experiment：
Method and apparatus
Melanin composite inhibiting of the present invention；PH=6.8 phosphate buffer solutions (PBS solution), sodium hydroxide (Chinese medicines group
Chemical reagent Co., Ltd)；TYR enzyme, Tyrosinase EC 1.14.18.19 (signa)；L-DOPA
(AcrosOrganics)；AB204-E electronic analytical balances (METTLE TOLEDO)；UV-1600 ultraviolet specrophotometers
(METTLE TOLEDO)。
During tyrosine is converted to melanin, the catalytic action of TYR enzyme occurs mainly in TYR enzyme and is converted into
DOPA and DOPA are converted to the process of DOPA quinone, and DOPA quinone is a kind of coloring matter, has absorption at 475nm, using light splitting
Photometer measurement content.L-DOPA is substrate, measures the TYR enzyme inhibitory activity of melanin composite inhibiting of the present invention.
Table 1
According to melanin composite inhibiting of the present invention, 0.15% DOPA solution is accurately drawn shown in table 1, it is sufficiently mixed equal
It is even, the TYR enzyme solution for adding in 300 μ/mL after ten minutes is incubated in 30 DEG C of water-baths, continues to cultivate ten minutes, exist immediately
475nm measures its light absorption value.
The calculation formula of TYR enzyme inhibiting rate (I) is as follows：
I=[(A-B)-(C-D)]/[A-B] × 100%
A:The absorbance A (A) that the enzyme mixed liquor of pigment composite inhibiting is surveyed is not blackened；
B:The absorbance A (B) that pigment composite inhibiting and not enzyme mixed liquor are surveyed is not blackened；
C：Blacken pigment composite inhibiting and enzyme absorbance A (C) mixed liquor, being surveyed；
D:Blacken the absorbance A (D) that the not enzyme mixed liquor of pigment composite inhibiting is surveyed.
Melanin composite inhibiting sample is diluted to 5%, 10%, 15%, 20% respectively with PBS, 25% detection is each
Concentration inhibits TYR enzyme activity.As a result 2 be see the table below：
Table 2
| Concentration (%) | Inhibiting rate (%) |
| 5 | 45 |
| 10 | 67 |
| 15 | 81 |
| 20 | 84 |
| 25 | 84 |
By 2 visible black color element composite inhibiting concentration of table 5% to 20% when, melanin composite inhibiting inhibits network
Propylhomoserin enzymatic activity increases with the growth of metering, and when TYR enzyme activity solubility is inhibited to reach 20%, TYR enzyme inhibits
Rate can reach 84%.
Embodiment 2
The preparation of skin whitener：
According to mass percent, by 10% caprylic/capric triglyceride, 1% cetostearyl alcohol, 2% 2 cetanol phosphoric acid
Ester, 2.5% white oil and 1% cyclic silicone oils heating stirring, up to oil phase, 0.5% are added in into 69.6% deionized water to 85 DEG C
Xanthans and 3% glycerine, and 85 DEG C are heated with stirring to up to water phase, gained oil phase is continued to stir under vacuum, then
Water phase is added in into oil phase, and continues to stir and emulsify, after emulsification, continues insulated and stirred 15min, hydrogen is added in after being cooled to 40 DEG C
Sodium oxide molybdena adjusts pH to neutrality, adds 0.2% Phenoxyethanol, 10% melanin composite inhibiting and 0.2% essence, fully
It stirs evenly.
Embodiment 3
The preparation of whitening emulsion：
It is according to mass percent, 3% stearine, 4% methyl sesquistearate, 2% sorb is smooth hard
Resin acid ester, 6% stearic acid, 8% stearyl alcohol, 1.5% benzophenone-3 Hybrid Heating are stirred to 85 DEG C, after stirring and dissolving is complete to obtain the final product
Oil phase；8% glycerine, 0.5% allantoin, 51.6% deionized water Hybrid Heating are stirred to 85 DEG C, stirring and dissolving is afterwards completely
Obtain water phase；Oil phase is added in water phase and is stirred 30 minutes, temperature is maintained at 85 DEG C；Then 0.1% hydroxyethyl cellulose guarantor is added in
Temperature stirring 30 minutes；It is cooled to 42 DEG C of 15% melanin composite inhibitings of addition, 0.3% Phenoxyethanols to stir evenly, cool down out
Material.
Embodiment 4
The preparation of whitening mask：
According to mass percent, 10% propylene glycol, 0.03% niacinamide, 8% glycerine, 15% butanediol, 3% β-Portugal are gathered
Sugar, 0.05% Sodium Hyaluronate, 0.05% panthenol, 0.5% allantoin, 0.6% hexylene glycol, 0.3%EDTA disodiums, 0.3% hydroxyl
Ethyl cellulose, 0.2% carbomer, 39.77% deionized water, which are added in agitated kettle, is heated with stirring to 85 DEG C, and stirring and dissolving is complete
Entirely, water phase is made；By 0.3% glycerine polymethacrylates, 0.8% hydrolysis Jojoba esters, 0.5%PEG-40 hydrogenated castors
Oil adds in agitated kettle and is heated with stirring to 85 DEG C, and oil phase is made；Under stirring, oil phase is added in into water phase, is stirred evenly；It is cooled to 45
DEG C, 0.1% triethanolamine is added in, is stirred evenly, is added 20% melanin composite inhibiting, 0.5% Phenoxyethanol, fully stir
Mix uniform postcooling discharging.
Embodiment 5
Human efficiency evaluates
To Examples 1 to 4 and a commercially available have effects that the cosmetics of whitening anti-wrinkling or skin care item (control group) try
Use detection result.Test object：Each experimental group is 20 women (25-50 Sui)；Test zone：Face；It uses：Daily two
It is secondary, persistently using 4 weeks；Test event：Whitening effect and anti-wrinkle effect.Result on trial see the table below 3：
Table 3
Apparent number is improved by 3 visible Examples 1 to 4 whitening of table and anti-wrinkle effect and is significantly more than control group, illustrates this
Invention lightening compositions and its skin whitener obtained, facial mask and lotion have significant whitening, anti-wrinkle effect.
Above example only illustrates embodiment of the present invention, and there is no the limitations having to the present invention in any form；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes or modification using the technology contents disclosed, becomes equivalent
The equivalent embodiment of variation according to the technology of the present invention essence, carries out simple modification, equivalent change and modification to the present invention, belongs to
In the range of technical solution of the present invention.
Claims (10)
1. a kind of melanin composite inhibiting, it is characterised in that component and content are：
It is mass parts above；
Wherein, tyrosinase inhibitor includes one kind in kojic acid, tribulus terrestris extraction, Paeonol, glabridin, asiaticosid
Or more ingredient；
Antioxidant then include one kind in fact in sub- haematochrome, vitamin C and its derivative, broussoflavone of carrotene, Chu or
More than ingredient.
2. composition as described in claim 1, it is characterised in that component and content are：
It is mass parts above；
Wherein, tyrosinase inhibitor includes one kind in kojic acid, tribulus terrestris extraction, Paeonol, glabridin, asiaticosid
Or more ingredient；
Antioxidant then include one kind in fact in sub- haematochrome, vitamin C and its derivative, broussoflavone of carrotene, Chu or
More than ingredient.
3. composition as claimed in claim 2, it is characterised in that component and content are：
It is mass parts above；
Wherein, tyrosinase inhibitor includes one kind in kojic acid, tribulus terrestris extraction, Paeonol, glabridin, asiaticosid
Or a kind of ingredient；
Antioxidant then include one kind in fact in sub- haematochrome, vitamin C and its derivative, broussoflavone of carrotene, Chu or
A kind of ingredient.
4. composition as described in claim 1, it is characterised in that：
The moisturizer include propylene glycol, hyaluronic acid, ceramide, bisabolol, in flores aurantii water it is one or more of into
Point；
The preservative include hydroxy methyl, Phenoxyethanol, Chlorphenesin, potassium sorbate, in pungent glycol it is one or more of into
Point.
5. composition as claimed in claim 2, it is characterised in that：
The moisturizer include propylene glycol, hyaluronic acid, ceramide, bisabolol, in flores aurantii water it is one or more of into
Point；
The preservative include hydroxy methyl, Phenoxyethanol, Chlorphenesin, potassium sorbate, in pungent glycol it is one or more of into
Point.
6. composition as claimed in claim 3, it is characterised in that：
The moisturizer include propylene glycol, hyaluronic acid, ceramide, bisabolol, in flores aurantii water it is one or more of into
Point；
The preservative include hydroxy methyl, Phenoxyethanol, Chlorphenesin, potassium sorbate, in pungent glycol it is one or more of into
Point.
7. composition as described in claim 1, it is characterised in that available for cosmetics.
8. composition as claimed in claim 2, it is characterised in that available for cosmetics.
9. composition as claimed in claim 3, it is characterised in that available for cosmetics.
10. such as claims 1 to 3 any one of them composition, it is characterised in that additive can be used as to be used for whitening class product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810192246.1A CN108186457A (en) | 2018-03-08 | 2018-03-08 | A kind of melanin composite inhibiting |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810192246.1A CN108186457A (en) | 2018-03-08 | 2018-03-08 | A kind of melanin composite inhibiting |
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| Publication Number | Publication Date |
|---|---|
| CN108186457A true CN108186457A (en) | 2018-06-22 |
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| CN201810192246.1A Withdrawn CN108186457A (en) | 2018-03-08 | 2018-03-08 | A kind of melanin composite inhibiting |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111249201A (en) * | 2020-03-25 | 2020-06-09 | 配方化妆品科技(广州)有限公司 | Vitamin water powder skin care composition and preparation method thereof |
-
2018
- 2018-03-08 CN CN201810192246.1A patent/CN108186457A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111249201A (en) * | 2020-03-25 | 2020-06-09 | 配方化妆品科技(广州)有限公司 | Vitamin water powder skin care composition and preparation method thereof |
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