CN107789230A - A kind of whitening additive - Google Patents
A kind of whitening additive Download PDFInfo
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- CN107789230A CN107789230A CN201711177550.0A CN201711177550A CN107789230A CN 107789230 A CN107789230 A CN 107789230A CN 201711177550 A CN201711177550 A CN 201711177550A CN 107789230 A CN107789230 A CN 107789230A
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- Prior art keywords
- whitening
- commercially available
- whitening additive
- additive
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of whitening additive, including the component such as tyrosinase inhibitor, NMF, antioxidant, wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.And have the advantages that:The wide lichee phloridzin of Fructificatio Tricholomatis Matsutakis extract combining source, can competitively suppress tyrosinase, can more efficiently reach whitening purpose;The whitening additive of the present invention has good moisturizing moisturizing effect, preferable in the film forming of skin surface, and can form skin protective barrier, also reduces the oxidative damage of skin;The whitening additive of the present invention has the advantages of safe, natural, efficient;The whitening additive of the present invention is applied in cosmetics, can not only assign cosmetics good whitening effect, moreover it is possible to Glycerin, to make skin more flexible.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of whitening additive.
Background technology
For melanin deposition more caused by internal and external many factors integrate, its genesis mechanism is a complicated physiology
Process.There is new understanding in recent years, such as " element of three enzyme one " is theoretical, but can't intactly explain the machine of melanin deposition
Reason, substantially still suppress around to tyrosinase to intervene the generating process of melanin deposition, so as to reach whitening flesh
The purpose of skin.In the market whitening and freckle-removing product continues to bring out out new brand in recent years, and Some Enterprises will have quick despeckle effect
The violated chemicals of fruit are added in cosmetics, and irreversible injury is formed to skin and body, and addition has white-skinned face function
Natural plant extracts also due to efficacy exertion is relatively slow and difficulty makes consumer satisfaction, although in the world generally acknowledged whitening active into
Point-the general effect of black bearberry is obvious, but addition is larger, and it is very strong to the excitant of skin.A kind of peace of research, exploitation and searching
Entirely, efficient whitening active ingredients are the focus and developing direction that beauty science makes great efforts research.
The content of the invention
It is an object of the invention to provide a kind of whitening additive, and applied in cosmetics, can competitively be pressed down
Tyrosinase processed, more efficiently reach whitening purpose
To achieve the above object, the present invention provides following technical scheme:
A kind of whitening additive, include the component of following mass parts:
Wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.
Further, a kind of described whitening additive includes the component of following mass parts:
Wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.
Further, described a kind of whitening additive, the component of following mass parts is included:
Wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.
In addition, described tyrosinase inhibitor by commercially available Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin according to 1:1~3 ratio
Example composition;
Described NMF includes commercially available glycerine, GONGBAOSU, sorbierite, chitin and its derivative composition;
It is blue or green that described antioxidant includes commercially available tocopherol, grape seed extract, wolfberry fruit extract, lycopene, shrimp
One or more in element;
Described natural antiseptic agent includes the one or more in commercially available Tea Polyphenols, eugenol, vanillic aldehyde.
Whitening additive of the present invention can be used for cosmetics, such as whitening class product.
Following introduction is done to the part material of the present invention:
Fructificatio Tricholomatis Matsutakis extract contains the compositions such as several amino acids, polysaccharide, vitamin and mineral, more in health products and medicine
It is employed, seldom the application in cosmetics.It is modern by Fructificatio Tricholomatis Matsutakis extract experimental studies have found that, Fructificatio Tricholomatis Matsutakis extract is to junket
The inhibitory action of propylhomoserin enzyme is better than ursin, and is applied in cosmetics and has the advantages of addition is low, effect is notable, has good
Good DEVELOPMENT PROSPECT.
Lichee phloridzin is its hydrolysate as a kind of novel whitening agent of pay attention to day by day in the world, its whitening mechanism
Tyrosinase activity in phloretin energy Reverse transcriptase dermal melanin cell, so as to disturb the synthesis of melanin, and its
Inhibiting rate is better than the ursin and kojic acid used in current many whitening products.
Compared with prior art, it is the device have the advantages that as follows:
(1) the wide lichee phloridzin of Fructificatio Tricholomatis Matsutakis extract combining source, can competitively suppress tyrosinase, can be more efficiently
Reach whitening purpose;(2) whitening additive of the invention has good moisturizing moisturizing effect, skin surface film forming compared with
It is good, and skin protective barrier can be formed, also reduce the oxidative damage of skin;(3) whitening additive of the invention has safety, day
So, the advantages of efficient;(4) whitening additive of the present invention is applied in cosmetics, can not only assigns cosmetics good U.S.
White effect, moreover it is possible to Glycerin, make skin more flexible.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The preparation of whitening additive:
By 2 grams of Fructificatio Tricholomatis Matsutakis extracts, 1 gram of lichee phloridzin, 6 grams of glycerine, 0.5 gram of GONGBAOSU, 2.5 grams of sorbierites, 5 grams of crusts
Element and its derivative, 4 grams of tocopherols, 0.02 gram of Tea Polyphenols and 78.98 grams of deionized waters are placed in blender, are stirred
It is even, you can to obtain whitening additive.
Human body patch test
Organize 30 volunteers according to《Cosmetics health specification》The human body skin patch Experimental Standardization of (2007 editions) records,
The whitening additive obtained by the embodiment of the present invention 1 is tested, as a result as shown in table 1.
Table 1
Whitening additive of the present invention is nonirritant to human body skin as can be seen from Table 1.
Tyrosinase activity suppresses experiment:
Method and apparatus
Whitening additive of the present invention;PH=6.8 phosphate buffer solutions (PBS solution), sodium hydroxide (Chinese medicines group chemistry examination
Agent Co., Ltd);TYR enzyme, TyrosinaseEC1.14.18.19 (signa);L-DOPA(AcrosOrganics);
AB204-E electronic analytical balances (METTLE TOLEDO);UV-1600 ultraviolet specrophotometers (METTLETOLEDO).
During TYR changes into melanin, the catalytic action of TYR enzyme occurs mainly in TYR enzyme and is converted into
DOPA and DOPA change into the process of DOPA quinone, and DOPA quinone is a kind of coloring matter, has absorption at 475nm, using light splitting
Photometer measurement content.L-DOPA is substrate, determines the TYR enzyme inhibitory activity of whitening additive of the present invention.
Table 2
According to whitening additive of the present invention, 0.15% DOPA solution is accurately drawn shown in table 2, be sufficiently mixed uniformly,
300 μ/mL TYR enzyme solution is added after being incubated 10 minutes in 30 DEG C of water-baths, continues to cultivate ten minutes, is surveyed immediately in 475nm
Its fixed light absorption value.
The calculation formula of TYR enzyme inhibiting rate (I) is as follows:
I=[(A-B)-(C-D)]/[A-B] × 100%
A:Not plus the absorbance A (A) surveyed of the enzyme-added mixed liquor of whitening additive;
B:Not plus the absorbance A (B) surveyed of whitening additive and not enzyme-added mixed liquor;
C:Add whitening additive and enzyme-added absorbance A (C) mixed liquor, being surveyed;
D:The absorbance A (D) that the mixed liquor for adding whitening additive not enzyme-added is surveyed.
Whitening additive sample is diluted to 5%, 10%, 15%, 20%, 25% respectively with PBS
Detect each concentration and suppress TYR enzyme activity.It the results are shown in Table 3.
Table 3
Concentration (%) | Inhibiting rate (%) |
5 | 45 |
10 | 67 |
15 | 81 |
20 | 84 |
25 | 84 |
By the visible whitening additive concentration of table 3 5% to 20% when, whitening additive suppress TYR enzyme activity with
The growth of metering and increase, when suppression TYR enzyme activity solubility reaches 20%, TYR enzyme inhibiting rate can reach 84%.
Embodiment 2
The preparation of skin whitener:
According to mass percent, by 10% caprylic/capric triglyceride, 1% cetostearyl alcohol, 2% 2 cetanol phosphoric acid
Ester, 2.5% white oil and 1% cyclic silicone oils heating stirring produce oil phase to 85 DEG C, and 0.5% is added into 69.6% deionized water
Xanthans and 3% glycerine, and be heated with stirring to 85 DEG C and produce aqueous phase, gained oil phase is continued to stir under vacuum, then
Aqueous phase is added into oil phase, and continues to stir and emulsifies, after emulsification, continues insulated and stirred 15min, hydrogen is added after being cooled to 40 DEG C
Sodium oxide molybdena adjusts pH to neutrality, adds 0.2% Phenoxyethanol, 10% whitening additive and 0.2% essence, is sufficiently stirred
It is even.
Embodiment 3
The preparation of whitening emulsion:
It is according to mass percent, 3% stearine, 4% methyl sesquistearate, 2% sorb is smooth hard
Resin acid ester, 6% stearic acid, 8% stearyl alcohol, 1.5% OXYBENZONE Hybrid Heating are stirred to 85 DEG C, are produced after stirring and dissolving is complete
Oil phase;8% glycerine, 0.5% allantoin, 51.6% deionized water Hybrid Heating are stirred to 85 DEG C, stirring and dissolving is afterwards completely
Obtain aqueous phase;Oil phase is added in aqueous phase and stirred 30 minutes, temperature is maintained at 85 DEG C;Then 0.1% hydroxyethyl cellulose guarantor is added
Temperature stirring 30 minutes;It is cooled to 42 DEG C of 15% whitening additives of addition, 0.3% Phenoxyethanols to stir, cooling discharging.
Embodiment 4
The preparation of cleawhite pack:
According to mass percent, 10% propane diols, 0.03% niacinamide, 8% glycerine, 15% butanediol, 3% β-Portugal are gathered
Sugar, 0.05% Sodium Hyaluronate, 0.05% panthenol, 0.5% allantoin, 0.6% hexylene glycol, 0.3%EDTA disodiums, 0.3% hydroxyl
Ethyl cellulose, 0.2% carbomer, 39.77% deionized water, which are added in agitated kettle, is heated with stirring to 85 DEG C, and stirring and dissolving is complete
Entirely, aqueous phase is made;By 0.3% glycerine polymethacrylates, 0.8% hydrolysis Jojoba esters, 0.5%PEG-40 hydrogenated castors
Oil adds in agitated kettle and is heated with stirring to 85 DEG C, and oil phase is made;Under stirring, oil phase is added into aqueous phase, stirred;It is cooled to 45
DEG C, 0.1% triethanolamine is added, is stirred, is added 20% whitening additive, 0.5% Phenoxyethanol, stir
Cooling discharging afterwards.
Embodiment 5
Human efficiency evaluates
Inspection on probation is carried out to embodiment 1~4 and a commercially available cosmetics or skin care item (control group) with white-skinned face function
Survey effect.Test object:Each experimental group is 20 women (25-50 year);Test zone:Face;Use:Twice daily, hold
It is continuous to use 4 weeks;Test event:Whitening effect and moistening effect.Result on trial see the table below 4.
Table 4
Obvious number is improved by the visible whitening of embodiment 1~4 of table 4 and moistening effect and is significantly more than control group, illustrates this
Invention lightening compositions and its obtained skin whitener, facial mask and emulsion have significant whitening, moistening effect.
Above example only illustrates embodiment of the present invention, does not have any formal limitation to the present invention;Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes or modification using the technology contents disclosed, turns into equivalent
The equivalent embodiment of change, according to the technology of the present invention essence, simple modification, equivalent change and modification is carried out to the present invention, belonged to
In the range of technical solution of the present invention.
Claims (10)
1. a kind of whitening additive, it is characterised in that composition is with content:
It is mass parts above;
Wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.
2. a kind of whitening additive as claimed in claim 1, it is characterised in that composition is with content:
It is mass parts above;
Wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.
3. a kind of whitening additive as claimed in claim 2, it is characterised in that composition is with content:
It is mass parts above;
Wherein, tyrosinase inhibitor contains Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin.
4. whitening additive as claimed in claim 1, it is characterised in that:
Described tyrosinase inhibitor is by commercially available Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin according to 1:1~3 ratio composition;
Described NMF includes commercially available glycerine, GONGBAOSU, sorbierite, chitin and its derivative composition;
Described antioxidant is included in commercially available tocopherol, grape seed extract, wolfberry fruit extract, lycopene, astaxanthin
One or more;
Described natural antiseptic agent includes the one or more in commercially available Tea Polyphenols, eugenol, vanillic aldehyde.
5. whitening additive as claimed in claim 2, it is characterised in that:
Described tyrosinase inhibitor is by commercially available Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin according to 1:1~3 ratio composition;
Described NMF includes commercially available glycerine, GONGBAOSU, sorbierite, chitin and its derivative composition;
Described antioxidant is included in commercially available tocopherol, grape seed extract, wolfberry fruit extract, lycopene, astaxanthin
One or more;
Described natural antiseptic agent includes the one or more in commercially available Tea Polyphenols, eugenol, vanillic aldehyde.
6. whitening additive as claimed in claim 3, it is characterised in that:
Described tyrosinase inhibitor is by commercially available Fructificatio Tricholomatis Matsutakis extract, lichee phloridzin according to 1:1~3 ratio composition;
Described NMF includes commercially available glycerine, GONGBAOSU, sorbierite, chitin and its derivative composition;
Described antioxidant is included in commercially available tocopherol, grape seed extract, wolfberry fruit extract, lycopene, astaxanthin
One or more;
Described natural antiseptic agent includes the one or more in commercially available Tea Polyphenols, eugenol, vanillic aldehyde.
7. whitening additive as claimed in claim 1, it is characterised in that available for cosmetics.
8. whitening additive as claimed in claim 2, it is characterised in that available for cosmetics.
9. whitening additive as claimed in claim 3, it is characterised in that available for cosmetics.
10. the whitening additive as described in any one of claims 1 to 3, it is characterised in that available for whitening class product.
Priority Applications (1)
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CN201711177550.0A CN107789230A (en) | 2017-11-22 | 2017-11-22 | A kind of whitening additive |
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CN201711177550.0A CN107789230A (en) | 2017-11-22 | 2017-11-22 | A kind of whitening additive |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108272676A (en) * | 2018-03-19 | 2018-07-13 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of Whitening, spot composition |
CN108912187A (en) * | 2018-09-19 | 2018-11-30 | 湖南中茂生物科技有限公司 | A method of extracting phloridzin from lychee exocarp |
CN110179698A (en) * | 2019-07-09 | 2019-08-30 | 福建师范大学 | A kind of skin whitening, moisturizing frost and preparation method thereof of the extract of Ke containing multiple-ear rock |
-
2017
- 2017-11-22 CN CN201711177550.0A patent/CN107789230A/en not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108272676A (en) * | 2018-03-19 | 2018-07-13 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of Whitening, spot composition |
CN108912187A (en) * | 2018-09-19 | 2018-11-30 | 湖南中茂生物科技有限公司 | A method of extracting phloridzin from lychee exocarp |
CN108912187B (en) * | 2018-09-19 | 2022-05-06 | 湖南中茂生物科技有限公司 | Method for extracting phlorizin from lychee shells |
CN110179698A (en) * | 2019-07-09 | 2019-08-30 | 福建师范大学 | A kind of skin whitening, moisturizing frost and preparation method thereof of the extract of Ke containing multiple-ear rock |
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Application publication date: 20180313 |